Digital Commons Network^™

A Deep Learning Convolutional Neural Network Can Recognize Common Patterns Of Injury In Gastric Pathology, David R. Martin, Joshua A. Hanson, Rama R. Gullapalli, Fred A. Schultz, Aisha Sethi, Douglas P. Clark

Pathology Research and Scholarship

CONTEXT.—: Most deep learning (DL) studies have focused on neoplastic pathology, with the realm of inflammatory pathology remaining largely untouched.

OBJECTIVE.—: To investigate the use of DL for nonneoplastic gastric biopsies.

DESIGN.—: Gold standard diagnoses were blindly established by 2 gastrointestinal pathologists. For phase 1, 300 classic cases (100 normal, 100

RESULTS.—: For Phase 1, receiver operating curves showed near perfect agreement with the gold standard diagnoses at an AD percentage cutoff of 50% for normal (area under the curve [AUC] = 99.7%) and

CONCLUSIONS.—: A convolutional neural network can serve as an effective screening tool/diagnostic aid for

Deconstructing Foundational Principles Of Trusts And Estates Law, Sergio Pareja

Faculty Scholarship

REVIEW: Naomi R. Cahn, Dismantling the Trusts and Estates Canon, 2019 Wis. L. Rev. 165 (2019).

All areas of the law have certain foundational principles or beliefs that are widely shared. These underlying assumptions often go unchallenged. In the trusts and estates field, these principles include: (1) giving a certain amount of ongoing control to the transferor, or in the case of a decedent, to the “dead hand,” (2) respect for formality, (3) the importance of the traditional, legally-recognized family, and (4) the “wealth” narrative that focuses on the transmission of conventional forms of wealth.

In her …

20200225_Brain Slice Specimens Have Been Relocated, Jonathan M. Pringle

HSLIC Blog Post

No abstract provided.

03-02-2020 Hsc Committee Notice, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

20200220_Meditation Sit In Hslic, Kelleen Maluski

HSLIC Blog Post

No abstract provided.

12-09-2019 Hsc Committee Meeting Minutes, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Outcomes Of Inflammatory Bowel Disease In Patients With Eosinophil-Predominant Colonic Inflammation, Tarik Alhmoud, Anas Gremida, Diego Colom Steele, Imaneh Fallahi, Wael Tuqan, Nina Nandy, Mahmoud Ismail, Barakat Aburajab Altamimi, Meng-Jun Xiong, Audra Kerwin, David Martin

Pathology Research and Scholarship

BACKGROUND: Inflammatory bowel disease (IBD) is characterised by acute intestinal mucosal inflammation with chronic inflammatory features. Various degrees of mucosal eosinophilia are present along with the typical acute (neutrophil-predominant) inflammation. The effect of intestinal eosinophils on IBD outcomes remains unclear.

METHODS: This is a retrospective study. Archived intestinal mucosal biopsy specimens of treatment-naïve IBD patients were examined by two pathologists. The number of eosinophils per high-power field was counted, and the mucosal inflammation was classified according to the eosinophilic inflammatory patterns. Clinical outcomes during the follow-up period were recorded.

RESULTS: 142 treatment-naïve IBD patients were included. Mean age was 39 …

2020-02-14 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

20200211_Join Us. Managing Impostor Syndrome Workshop, Kelleen Maluski

HSLIC Blog Post

No abstract provided.

Dynamic Imaging Of Ldh Inhibition In Tumors Reveals Rapid In Vivo Metabolic Rewiring And Vulnerability To Combination Therapy, Nobu Oshima, Ryo Ishida, Shun Kishimoto, Kristin Beebe, Jeffrey R. Brender, Kazutoshi Yamamoto, Daniel Urban, Ganesha Rai, Michelle S. Johnson, Gloria Benavides, Giuseppe L. Squadrito, Dan Crooks, Joseph Jackson, Abhinav Joshi, Bryan T. Mott, Jonathan H. Shrimp, Michael A. Moses, Min-Jung Lee, Akira Yuno, Tobie D. Lee, Xin Hu, Tamara Anderson, Donna Kusewitt, Helen H. Hathaway, Ajit Jadhav, Didier Picard, Jane B. Trepel, James B. Mitchell, Gordon M. Stott, William Moore, Anton Simeonov, Larry A. Sklar, Jeffrey P Norenberg, W Marston Linehan, David J. Maloney, Chi V. Dang, Alex G. Waterson, Matthew Hall, Victor M. Darley-Usmar, Murali C. Krishna, Leonard M. Neckers

Pathology Research and Scholarship

The reliance of many cancers on aerobic glycolysis has stimulated efforts to develop lactate dehydrogenase (LDH) inhibitors. However, despite significant efforts, LDH inhibitors (LDHi) with sufficient specificity and in vivo activity to determine whether LDH is a feasible drug target are lacking. We describe an LDHi with potent, on-target, in vivo activity. Using hyperpolarized magnetic resonance spectroscopic imaging (HP-MRSI), we demonstrate in vivo LDH inhibition in two glycolytic cancer models, MIA PaCa-2 and HT29, and we correlate depth and duration of LDH inhibition with direct anti-tumor activity. HP-MRSI also reveals a metabolic rewiring that occurs in vivo within 30 min …

Improving The Delivery Of Musculoskeletal Education In Primary Care Using The Innovative Echo (Extension For Community Healthcare Outcomes) Technology, Katharine Spalding, Ian Ryans, Neil Heron

Project ECHO Bibliography

Background: Extension for Community Healthcare Outcomes (ECHO) is a programme that employs videoconferencing technology to train community-based primary care providers to improve and standardize care across a wide geographical region. This method has not yet been trialled in the UK for improving the capacity of primary care services in managing common musculoskeletal (MSK) complaints.

Aim: The aim was to assess the impact of introducing a year-long MSK ECHO education programme in Northern Ireland for general practitioners (GPs).

Design and setting: Monthly sessions were held consisting of teaching and case based discussions. Each session lasted on average 90 minutes. A ‘hub’ …

The Impact Of An Undergraduate Biology Class On Donor Recruitment At A Hospital-Based Blood Donor Center, Alexis R. Peedin, Yara A. Park, Marshall A. Mazepa, Thomas Neish, Jay S. Raval, R Chad Siniard

Pathology Research and Scholarship

OBJECTIVES: A biology class, BIOL 294H, taught undergraduates about platelet donation while partnering with the University of North Carolina's (UNC's) hospital-based Blood Donation Center to recruit apheresis platelet donors. We identified our platelet donors' demographics and learned how BIOL 294H affected recruitment.

METHODS: Every platelet donor presenting to the UNC Blood Donation Center from February 7, 2017, to March 10, 2017, was asked to complete an electronic 10-question survey.

RESULTS: A total of 159 unique donors completed the survey; 64% were female and 75% were between ages 18 and 25 years. Overall, 70% were UNC undergraduate students. Over half (56%) …

02-11-2020 Hsc Committee Agenda (Revised), Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

20200204_Hslic Welcomes David Lucero, Tamara Wheeler

HSLIC Blog Post

No abstract provided.

2020-02-04 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

20200203_Hslic's Biomedical Informatics Seminar Series Presents Gary Iwamoto, Md, Tamara Wheeler

HSLIC Blog Post

No abstract provided.

Recommendations For Clinical Laboratory Testing For Protein C Deficiency, For The Subcommittee On Plasma Coagulation Inhibitors Of The Isth, Peter C. Cooper, Anna Pavlova, Gary W. Moore, Kieron P. Hickey, Richard A. Marlar

Pathology Research and Scholarship

Inherited protein C (PC) deficiency increases risk of venous thromboembolism (VTE) by 5 to 10-fold in thrombosis-prone families; however, heterozygous PC deficiency alone does not determine that a subject has thrombophilia. Protein C deficient subjects, who lack additional inherited risk factors such as factor V Leiden or have no major acquired risk factors, may not suffer from VTE. In addition, PC deficiency may be acquired, often due to vitamin K antagonist treatment or liver disease. In contrast, homozygous or compound heterozygous PC deficiencies are rare and serious disorders, and affected infants are often in families with no history of PC …

Evaluation Of Commercial Next-Generation Sequencing Bioinformatics Software Solutions, Rama R. Gullapalli

Pathology Research and Scholarship

Next-generation sequencing (NGS) diagnostics continue to expand rapidly in clinical medicine. An ever-expanding menu of molecular biomarkers is deemed important for diagnostic, prognostic, and therapeutic assessment in patients. The increasing role of NGS in the clinic is driven mainly by the falling costs of sequencing. However, the data-intensive nature of NGS makes bioinformatic analysis a major challenge to many clinical laboratories. Critically needed NGS bioinformatics personnel are hard to recruit and retain in small- to mid-size clinical laboratories. Also, NGS software often lacks the scalability necessary for expanded clinical laboratory testing volumes. Commercial software solutions aim to bridge the bioinformatics …

Evaluation Of Unm's Parental Leave Policy, Julia Fulghum, Karlyn A. Edwards, Charlie Christian, Steven Verney, Lisa A. Marchiondo, Teagan Mullins

ADVANCE Reports

Experiences with UNM’s parental leave policy C215 have been evaluated using the ADVANCE 2018 Main Campus Faculty Climate Survey, a series of junior faculty interviews, and concerns brought to the ADVANCE leadership. Key findings are:

• Women and STEM faculty are more hesitant to use family-leave policies, and perceive greater disadvantage in using them than men and non-STEM faculty
• Sharing of information about, and implementation of, parental leave varies significantly between units
• The attitude of the department chair and senior faculty strongly influence the experience of faculty who use parental leave
• Appropriately implemented, the parental leave policy contributes to faculty recruitment …

Coalition For Prisoners' Rights Newsletter, Vol 45-B, No. [2], Coalition For Prisoners' Rights

Coalition for Prisoners' Rights Newsletters

Solidarity Not Solitary: Contradictions Sharpen

El Número de Menores de Edad Sin Hogar

Mas Aceso a Licencias de Conducir

Striving for Redemption

Some Limits on Solitary Confinement

Echo Telementoring For Pain, Palliative Care, And Opioid Management: Progress, Challenges, And Future Goals, Joanna G. Katzman

Project ECHO Bibliography

The article in this issue of Pain Medicine by Flynn et al., “Pain Management Telementoring, Long-term Opioid Prescribing, and Patient-Reported Outcomes,” demonstrates patient-level reductions in opioid doses in patients whose clinicians actively participate in pain telementoring as compared with patients whose clinicians participate in pain telementoring at a low level. These outcome data reflect the growing body of evidence that telementoring may improve opioid prescribing and pain management practices.

Rtk Signaling Requires C3ar1/C5ar1 And Il-6r Joint Signaling To Repress Dominant Pten, Socs1/3 And Phlpp Restraint, Michael G. Strainic, Elliot Pohlmann, Christopher C. Valley, Ajay Sammeta, Wasim Hussain, Diane S. Lidke, M Edward Medof

Pathology Research and Scholarship

How receptor tyrosine kinase (RTK) growth signaling is controlled physiologically is incompletely understood. We have previously provided evidence that the survival and mitotic activities of vascular endothelial cell growth factor receptor-2 (VEGFR2) signaling are dependent on C3a/C5a receptor (C3ar1/C5ar1) and IL-6 receptor (IL-6R)-gp130 joint signaling in a physically interactive platform. Herein, we document that the platelet derived and epidermal growth factor receptors (PDGFR and EGFR) are regulated by the same interconnection and clarify the mechanism underlying the dependence. We show that the joint signaling is required to overcome dominant restraint on RTK function by the combined repression of tonically activated …

20200130_Bullet Journaling & Digital Tracking 101 - An Introductory Workshop On Thursday, February 6th, Kelleen Maluski

HSLIC Blog Post

No abstract provided.

A Multicenter Study Of The Revogene C. Difficile System For Detection Of The Toxin B Gene From Unformed Stool Specimens, Michael J. Mashock, Matthew L. Faron, Karen C. Carroll, Christina Dang, Shawna Lewis, Hossein Salimnia, Paul Lephart, Vivian G. Loo, Bryan H. Schmitt, Stephen Young, Blake W. Buchan, Nathan A. Ledeboer

Pathology Research and Scholarship

Clostridioides difficile is the leading cause of diarrhea in hospitalized U.S. patients and results in over 400,000 cases of C. difficile infection per year. C. difficile infections have mortality rates of 6 to 30% and significantly increase health care costs, because of increased length of stay and increased frequency of readmissions due to recurrences. Efforts to reduce the spread of C. difficile in hospitals have led to the development of rapid sensitive diagnostic methods. A multicenter study was performed to establish the performance characteristics of the Revogene C. difficile test (Meridian Bioscience, Cincinnati, OH, USA) for use in detection of …

20200124_Things Are Coming Together, Laura J. Hall

HSLIC Blog Post

No abstract provided.

Ipe High Points, The Unm Hsc Inter-Professional Education Team

The IPE Newsletters

Shadowing a Community Health Worker (CHW): Social Determinants of Health

A Randomized Trial Of Erythropoietin For Neuroprotection In Preterm Infants, Sandra E Juul, Bryan A Comstock, Rajan Wadhawan, Dennis E Mayock, Sherry E Courtney, Tonya Robinson, Kaashif A Ahmad, Ellen Bendel-Stenzel, Mariana Baserga, Edmund F Lagamma, L Corbin Downey, Raghavendra Rao, Nancy Fahim, Andrea Lampland, Ivan D Frantz Iii, Janine Y Khan, Michael Weiss, Maureen M Gilmore, Robin K Ohls, Nishant Srinivasan, Jorge E Perez, Victor Mckay, Phuong T Vu, Jean Lowe, Karl Kuban, T Michael O'Shea, Adam L Hartman, Patrick J Heagerty, Penut Trial Consortium

Pediatrics Research and Scholarship

BACKGROUND: High-dose erythropoietin has been shown to have a neuroprotective effect in preclinical models of neonatal brain injury, and phase 2 trials have suggested possible efficacy; however, the benefits and safety of this therapy in extremely preterm infants have not been established.

METHODS: In this multicenter, randomized, double-blind trial of high-dose erythropoietin, we assigned 941 infants who were born at 24 weeks 0 days to 27 weeks 6 days of gestation to receive erythropoietin or placebo within 24 hours after birth. Erythropoietin was administered intravenously at a dose of 1000 U per kilogram of body weight every 48 hours for …

20200115_Hslic's Biomedical Informatics Seminar Series Presents Marianne Berwick, Phd, Mph, Tamara Wheeler

HSLIC Blog Post

No abstract provided.

Clinical Diagnostics And Treatment Strategies For Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia, Richard C. Harvey, Sarah K. Tasian

Pathology Research and Scholarship

Philadelphia chromosome-like B-cell acute lymphoblastic leukemia (Ph-like ALL) accounts for 15% to 30% of B-cell acute lymphoblastic leukemia in older children, adolescents, and adults and is associated with high rates of conventional treatment failure and relapse. Current clinical trials are assessing the efficacy of the addition of tyrosine kinase inhibitors (TKIs) to chemotherapy for children and adults with Ph-like ALL harboring ABL class translocations or CRLF2 rearrangements and other JAK pathway alterations. However, real-time diagnosis of patients can be quite challenging given the genetic heterogeneity of this disease and the often cytogenetically cryptic nature of Ph-like ALL-associated alterations. In this …

Eat Smart Message 2019 United Spanish, Glenda Canaca

Fruits and Vegetables

No abstract provided.