Digital Commons Network^™

20200331_Free Resources During Covid19 For Education, Robyn Gleasner

HSLIC Blog Post

No abstract provided.

2020-03-30 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

20200327_Student Resources, Tamara Wheeler

HSLIC Blog Post

No abstract provided.

2020-03-27 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

2020-03-26 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

Association Of Immunophenotype With Expression Of Topoisomerase Ii Α And Β In Adult Acute Myeloid Leukemia, Andrew P. Michelson, Shannon Mcdonough, Cheryl L. Willman, Eric R. Koegle, John E. Godwin, Stephen H. Petersdorf, Alan F. List, Megan Othus, Frederick R. Appelbaum, Jerald P. Radich, Mahrukh K. Ganapathi, Anjali S. Advani, Ram N. Ganapathi

Pathology Research and Scholarship

Anthracyclines used in the treatment of acute myelogenous leukemia (AML) inhibit the activity of the mammalian topoisomerase II (topo II) isoforms, topo II α and topo IIβ. In 230 patients with non-M3 AML who received frontline ara-C/daunorubicin we determined expression of topo IIα and topo IIβ by RT-PCR and its relationship to immunophenotype (IP) and outcomes. Treatment outcomes were analyzed by logistic or Cox regression. In 211 patients, available for analysis, topo IIα expression was significantly lower than topo IIβ (P < 0.0001). In contrast to topo IIα, topo IIβ was significantly associated with blast percentage in marrow or blood (P = 0.0001), CD7 (P = 0.01), CD14 (P < 0.0001) and CD54 (P < 0.0001). Event free survival was worse for CD56-negative compared to CD56-high (HR = 1.9, 95% CI [1.0-3.5], p = 0.04), and overall survival was worse for CD-15 low as compared to CD15-high (HR = 2.2, 95% CI [1.1-4.2], p = 0.02). Ingenuity pathway analysis indicated topo IIβ and immunophenotype markers in a network associated with cell-to-cell signaling, hematological system development/function and inflammatory response. Topo IIβ expression reflects disease biology of highly proliferative disease and distinct IP but does not appear to be an independent variable influencing outcome in adult AML patients treated with anthracycline-based therapy.

The Mk2 Pathway Is Linked To G-Csf, Cytokine Production And Metastasis In Gastric Cancer: A Novel Intercorrelation Analysis Approach, Fares Qeadan, Pranshu Bansal, Joshua A. Hanson, Ellen J. Beswick

Pathology Research and Scholarship

BACKGROUND: Gastric cancer is associated with chronic inflammation, but there is still much to understand about the tumor microenvironment and the underlying tumor-promoting mechanisms. The Map kinase-activated protein kinase 2 (MK2) pathway is a regulator of inflammatory cytokine production that we have been studying in gastrointestinal cancers. Here, we set out to determine the significance of this gene in gastric cancer along with its downstream mediators and if there were differences in the primary tumors with and without metastasis.

METHODS: Human gastric cancer tissues with and without metastasis were examined for MK2 expression and cytokine profile in organ culture supernatants. …

2020-03-25 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

Clinical Performance Of The Novel Genmark Dx Eplex Blood Culture Id Gram-Positive Panel, Karen C. Carroll, Jennifer L. Reid, Adam Thornberg, Natalie N. Whitfield, Deirdre Trainor, Shawna Lewis, Teresa Wakefield, Thomas E. Davis, Keisha G. Church, Linoj Samuel, Ray Mills, Patricia Jim, Stephen Young, Frederick S. Nolte

Pathology Research and Scholarship

Rapid identification from positive blood cultures is standard of care (SOC) in many clinical microbiology laboratories. The GenMark Dx ePlex Blood Culture Identification Gram-Positive (BCID-GP) Panel is a multiplex nucleic acid amplification assay based on competitive DNA hybridization and electrochemical detection using eSensor technology. This multicenter study compared the investigational-use-only (IUO) BCID-GP Panel to other methods of identification of 20 Gram-positive bacteria, four antimicrobial resistance genes, and both Pan

20200324_Coronavirus Disease 2019 (Covid-19) Guide, Kelleen Maluski

HSLIC Blog Post

No abstract provided.

2020-03-24 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

2020-03-23 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

20200323_Supporting Our Hsc Faculty Transitioning To Virtual Instruction, Jonathan M. Pringle

HSLIC Blog Post

No abstract provided.

Analyzing Age Group And Time Of The Day Using Interval Valued Neutrosophic Sets, S. Broumi, M. Lathamaheswari, A. Bakali, M. Talea, F. Smarandache, D. Nagarajan, Kavikumar Kavikumar, Guennoun Asmae

Neutrosophic Sets and Systems

No abstract provided.

Air Pollution Model Using Neutrosophic Cubic Einstein Averaging Operators, Majid Khan, Muhammad Gulistan, Nasruddin Hassan, Abdul Muhaimin Nasruddin

Neutrosophic Sets and Systems

No abstract provided.

2020-03-20 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

20200320_Coronavirus Resource 3, Tamara Wheeler

HSLIC Blog Post

No abstract provided.

2020-03-19 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

20200319_Access Resources From Off-Campus, Robyn Gleasner

HSLIC Blog Post

No abstract provided.

20200319_Virtual Library, Kristin R. Proctor

HSLIC Blog Post

No abstract provided.

20200319_Coronavirus Resource 2, Tamara Wheeler

HSLIC Blog Post

No abstract provided.

20200318_Canceled - 3.19.2020 Biomiss, Tamara Wheeler

HSLIC Blog Post

No abstract provided.

2020-03-18 A Message From Chancellor Roth (2), Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

2020-03-18 A Message From Chancellor Roth (1), Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

20200318_Coronavirus Resource 1, Tamara Wheeler

HSLIC Blog Post

No abstract provided.

2020-03-17 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

20200316_Postponing Events, Kelleen Maluski

HSLIC Blog Post

No abstract provided.

2020-03-16 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

20200314_Bullet Journaling - Group Support, Kelleen Maluski

HSLIC Blog Post

No abstract provided.

Unsecured (Black) Bodies: How Baltimore Foreshadows The Dangers Of Racially Targeted Dragnet Policing Let Loose By Utah V. Strieff, Lucius T. Outlaw Iii

New Mexico Law Review

Through Utah v. Strieff, the Supreme Court has added to law enforcement’s arsenal of stripping people of their citizenship and humanity. This article strives to add to the growing criticism of Strieff in three ways.

First, it adds to the chorus of work exposing and criticizing the flawed legal reasoning of the majority opinion.

Next, by using Baltimore, Maryland’s recent policing history, this article shows how racially targeted dragnet policing was already a fact of life pre-Strieff for many black residents of our cities, and how this discriminatory policing tactic is fortified and encouraged by Strieff.

Finally, …