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Articles 3571 - 3600 of 56108
Full-Text Articles in Entire DC Network
Virtual And In Vitro Antiviral Screening Revive Therapeutic Drugs For Covid-19, Giovanni Bocci, Steven B. Bradfute, Chunyan Ye, Matthew J. Garcia, Jyothi Parvathareddy, Walter Reichard, Surekha Surendranathan, Shruti Bansal, Cristian G. Bologa, Douglas J. Perkins, Colleen B. Jonsson, Tudor I. Oprea, Larry A. Sklar
Virtual And In Vitro Antiviral Screening Revive Therapeutic Drugs For Covid-19, Giovanni Bocci, Steven B. Bradfute, Chunyan Ye, Matthew J. Garcia, Jyothi Parvathareddy, Walter Reichard, Surekha Surendranathan, Shruti Bansal, Cristian G. Bologa, Douglas J. Perkins, Colleen B. Jonsson, Tudor I. Oprea, Larry A. Sklar
Pathology Research and Scholarship
The urgent need for a cure for early phase COVID-19 infected patients critically underlines drug repositioning strategies able to efficiently identify new and reliable treatments by merging computational, experimental, and pharmacokinetic expertise. Here we report new potential therapeutics for COVID-19 identified with a combined virtual and experimental screening strategy and selected among already approved drugs. We used hydroxychloroquine (HCQ), one of the most studied drugs in current clinical trials, as a reference template to screen for structural similarity against a library of almost 4000 approved drugs. The top-ranked drugs, based on structural similarity to HCQ, were selected for in vitro …
Impact Of Cd82 Expression On Acute Myeloid Leukemia Chemosensitivity And Quiescence, Muskan Floren
Impact Of Cd82 Expression On Acute Myeloid Leukemia Chemosensitivity And Quiescence, Muskan Floren
Biomedical Sciences ETDs
Acute Myeloid Leukemia (AML) patients respond favorably to induction chemotherapy, however, long-term outcomes remain poor due to a high rate of chemoresistance and bone marrow minimal residual disease. To improve long-term patient outcomes, it’s critical to identify regulators of chemotherapy resistance in AML and develop therapies that are directed towards bone marrow resident AML cells. In Chapter 2, we uncover the impact of CD82 expression in AML response to chemotherapeutic treatment and the contribution of Protein Kinase C α (PKCα) and β1 integrin signaling in promoting p38 MAPK activation to support CD82-mediated AML cell survival. In Chapter 3, we …
Climate Change: Increased Potential For Fire Disaster In Taos, New Mexico, Matthew F. Vigil
Climate Change: Increased Potential For Fire Disaster In Taos, New Mexico, Matthew F. Vigil
Climate Change and Public Health Preparedness
No abstract provided.
Unm Newsroom Interviews Nathalie Martin: Unm Law Professor Practices Yoga And Meditation In Stressful Times, Nathalie Martin, Maggie Branch
Unm Newsroom Interviews Nathalie Martin: Unm Law Professor Practices Yoga And Meditation In Stressful Times, Nathalie Martin, Maggie Branch
Faculty Scholarship
A professor at The University of New Mexico School of Law has become a very accomplished Yogi – someone who studies and is proficient in yoga. Nathalie Martin, who has been a part of the UNM law faculty since 1998, was featured in a magazine put together by the Property Brothers and HGTV regarding her Yogi status.
20201207_Announcing The New Hsc Policymanager Platform, David Lucero
20201207_Announcing The New Hsc Policymanager Platform, David Lucero
HSLIC Blog Post
No abstract provided.
Farmers’ Place-Based Discourse About Water Relations: Ways Of Knowing Water And Multispecies Survival, Jeffrey Alan Hoffmann
Farmers’ Place-Based Discourse About Water Relations: Ways Of Knowing Water And Multispecies Survival, Jeffrey Alan Hoffmann
Communication ETDs
The present study looks at farmers’ discourse about water and water relations. Through qualitative interviews using the method of cultural discourse analysis (CuDA), and the framework of ecocultural dialectics, the study reveals how, as farmers talk about water, they also make explicit and implicit arguments about specific cultural relations with the biosphere, as well as the role of identity, place, and power in designing and implementing agricultural solutions to ecological and social problems. I argue that the contradictions in how farmers discursively envision the problems of water pollution and scarcity, as well as solutions to those problems in their farming …
06.23.2020 Board Of Medical Investigators State Of New Mexico Meeting Minutes, Anthony Cervantes
06.23.2020 Board Of Medical Investigators State Of New Mexico Meeting Minutes, Anthony Cervantes
Office of the Medical Investigator Notices and Agendas
No abstract provided.
Mothers’ Satisfaction With Childcare Choices And Its Links To Family Involvement And Community Support, Hadeel Shamlan Al-Essa
Mothers’ Satisfaction With Childcare Choices And Its Links To Family Involvement And Community Support, Hadeel Shamlan Al-Essa
Individual, Family, and Community Education ETDs
This study examined mothers ’reports on types of childcare arrangement for a preschool-age child, levels of mothers’, fathers’, and relatives’ involvement in childcare at home, maternal satisfaction with childcare arrangement, the influence of socioeconomic status and social support on mothers ’satisfaction with childcare arrangement, and the nature of mothers ’affection, responsiveness, encouragement, and teaching behaviors during mother-child play sessions. The sample consisted of 130 New Mexico mothers from two-parent families with a preschool child. A subsample of four mothers was selected for collecting data on mother-child play interactions through a 10-minute observation session. Analyses suggested that mothers were the primary …
The Effects Of Glycosylation On Immunogenicity And Replication Of Emerging Viral Pathogens, Elizabeth Carvosso Clarke
The Effects Of Glycosylation On Immunogenicity And Replication Of Emerging Viral Pathogens, Elizabeth Carvosso Clarke
Biomedical Sciences ETDs
For filoviruses, a family of hemorrhagic fever viruses, the main antigen for vaccines in development is the glycosylated glycoprotein GP1,2. How the glycosylation of GP1,2 differs when the protein is produced in different cell lines is unclear. We showed significant differences in the types of glycans conferred onto filovirus GP1,2s in produced in mammalian-origin and insect-origin cell lines. Mammalian-derived filovirus GP1,2s have diverse N-linked glycans and extensive O-linked glycans, whereas insect-derived filovirus GP1,2s have N-linked glycans that are primarily paucimannose type and have no observable O-linked glycans. We then showed that differences in glycosylation impacted how immunogenic the proteins were …
Full Issue (Fall 2020)
Intersections: Critical Issues in Education
No abstract provided.
Ibram X. Kendi's How To Be An Antiracist, Quatez Scott
Ibram X. Kendi's How To Be An Antiracist, Quatez Scott
Intersections: Critical Issues in Education
This book review of Ibram X. Kendi’s How to Be an Antiracist (2019) addresses the importance of exploring race relations in the U.S. from a framework that focuses on racial policies. Commonly referred to as “systemic racism” and “institutional racism”, racist policies maintain racial inequities. Antiracists aim to eliminate those racial policies. Kendi’s ability to address these issues head on with deeply researched historical narratives brings light to the ways racial policies are reinforced, which reproduce racist ideas. This book drives straight to the heart of racial challenges and takes a new approach at examining how and why humans should …
English Proficiency Or Post-School Success? The Miseducation Of English Learners, Jatnna Acosta
English Proficiency Or Post-School Success? The Miseducation Of English Learners, Jatnna Acosta
Intersections: Critical Issues in Education
English learners in the U.S. are academically unprepared at the secondary level, ad such systemic barriers lead to limited opportunities for post-school success (Umansky, 2016). Additional research is necessary to examine the correlation between the impact of a school’s ethnic diversity on the academic achievement of students identified as ELs. The purpose of this study is to investigate the educational outcomes of ELs at the high school level as a result of the school’s ethnic diversity. This study provides quantitative data from the Ed-Data Education Data Partnership. The data is disaggregated by the ethnic diversity index, percentage of enrolled ELs …
A Theory/Practice Divide: Exploring Perceptions Of Inclusion In Schools, Christine L. Cho
A Theory/Practice Divide: Exploring Perceptions Of Inclusion In Schools, Christine L. Cho
Intersections: Critical Issues in Education
This article explores the theory-practice divide with respect to actualizing how diversity and inclusion can be explicitly addressed in schools. This paper contributes important insights for teacher educators in terms of recognizing and challenging problematic assumptions teacher candidates (TCs) may hold. This research presses TCs to examine the structure of schools through a critical lens, as teachers, particularly those from the dominant group, tend to act in surface ways, avoiding conflict by using seemingly inclusive language and ideas, and either ignoring or not seeing the real challenges many historically marginalized students face. The assignment upon which this study was based …
Between The Visceral And The Lie : Lessons On Teaching Violence, Brian Gibbs
Between The Visceral And The Lie : Lessons On Teaching Violence, Brian Gibbs
Intersections: Critical Issues in Education
Drawing from two qualitative case studies, one researching how teachers teach about war to the children of soldiers and the other examining how teachers teach lynching near historic lynching sites, this critical phenomenological study weighs how much horror and how much hope should be taught if the aim of the instruction is a liberating education. The author argues that a balance of both is necessary. Students cannot be left in the hopelessness of knowledge alone but must be taught how to engage their world with the possibility of making change.
New Mexico: Land Of The Drought, Brandi Davis
New Mexico: Land Of The Drought, Brandi Davis
Climate Change and Public Health Preparedness
No abstract provided.
Unm Hslic Organizational Chart 2020, Sally Bowler-Hill
Unm Hslic Organizational Chart 2020, Sally Bowler-Hill
HSLIC Organizational Charts
No abstract provided.
Breast Cancer Screening Among Medically Underserved Women In New Mexico: Potential For Lower Recall Rates With Digital Breast Tomosynthesis, Martha T Manda-Mapalo, Stephanie G Fine, Sarah Safadi, Ji-Hyun Lee, Ruofei Du, Andrew L Sussman, Shiraz Mishra, Reed G Selwyn, Jennifer L Saline, Wendy L Hine, Ursa A Brown-Glaberman
Breast Cancer Screening Among Medically Underserved Women In New Mexico: Potential For Lower Recall Rates With Digital Breast Tomosynthesis, Martha T Manda-Mapalo, Stephanie G Fine, Sarah Safadi, Ji-Hyun Lee, Ruofei Du, Andrew L Sussman, Shiraz Mishra, Reed G Selwyn, Jennifer L Saline, Wendy L Hine, Ursa A Brown-Glaberman
Pediatrics Research and Scholarship
Introduction: Digital breast tomosynthesis (DBT) may decrease recall rates (RRs) and improve positive predictive values (PPVs) and cancer detection rates (CDRs) versus full-field digital mammography (FFDM). The value of DBT has not been assessed in New Mexico's rural and minority population. Objectives of this study were to compare RRs, CDRs, and PPVs using FFDM+DBT versus FFDM in screening mammograms at the University of New Mexico between 2013 and 2016 and to qualitatively evaluate patient decision-making regarding DBT. Materials and Methods: RRs, CDRs, and PPVs with 95% confidence intervals and relative risk were calculated from 35,147 mammograms. The association between relative …
Adverse Event Reporting For Cellular Therapy Products: Current Status And Future Directions, Kathy Loper, Michele W. Sugrue, Jay S. Raval, Joseph Yossi Schwartz, Kevin Land, Mickey Koh, Thilo Mengling, Hildegard Greinix, Jörg P. Halter, Christina M Celluzzi, Maysum Chaudhri
Adverse Event Reporting For Cellular Therapy Products: Current Status And Future Directions, Kathy Loper, Michele W. Sugrue, Jay S. Raval, Joseph Yossi Schwartz, Kevin Land, Mickey Koh, Thilo Mengling, Hildegard Greinix, Jörg P. Halter, Christina M Celluzzi, Maysum Chaudhri
Pathology Research and Scholarship
Adverse event (AE) and adverse reaction (AR) reporting are key components of patient safety and surveillance systems. Review and analysis of this data yields opportunities for process improvement, product information and interventions, and can lead to improved patient outcomes and donor safety overall. AE and AR reporting for cellular therapy products is fragmented and not well characterized in a central reference. This review article, authored by experts from various organizations, serves to summarize the current state of reporting and offers opportunities for streamlining and coordination, as well as key reference for professionals in this field.
Evolution Of The Epigenetic Landscape In Childhood B Acute Lymphoblastic Leukemia And Its Role In Drug Resistance, Shella Saint Fleur-Lominy, Nikki A. Evensen, Teena Bhatla, Gunjan Sethia, Sonali Narang, Jun H. Choi, Xiaotu Ma, Jun J. Yang, Stephen Kelly, Elizabeth Raetz, Richard C. Harvey, Cheryl Willman, Mignon L. Loh, Stephen P. Hunger, Patrick A. Brown, Kylie M. Getz, Cem Meydan, Christopher E. Mason, Aristotelis Tsirigos, William Carroll
Evolution Of The Epigenetic Landscape In Childhood B Acute Lymphoblastic Leukemia And Its Role In Drug Resistance, Shella Saint Fleur-Lominy, Nikki A. Evensen, Teena Bhatla, Gunjan Sethia, Sonali Narang, Jun H. Choi, Xiaotu Ma, Jun J. Yang, Stephen Kelly, Elizabeth Raetz, Richard C. Harvey, Cheryl Willman, Mignon L. Loh, Stephen P. Hunger, Patrick A. Brown, Kylie M. Getz, Cem Meydan, Christopher E. Mason, Aristotelis Tsirigos, William Carroll
Pathology Research and Scholarship
Although B-cell acute lymphoblastic leukemia (B-ALL) is the most common malignancy in children and while highly curable, it remains a leading cause of cancer-related mortality. The outgrowth of tumor subclones carrying mutations in genes responsible for resistance to therapy has led to a Darwinian model of clonal selection. Previous work has indicated that alterations in the epigenome might contribute to clonal selection, yet the extent to which the chromatin state is altered under the selective pressures of therapy is unknown. To address this, we performed chromatin immunoprecipitation, gene expression analysis, and enhanced reduced representation bisulfite sequencing on a cohort of …
Breast Tall Cell Carcinoma With Reversed Polarity With An Unusual Molecular Profile, Kaitlyn J. Nielson, Edgar G. Fischer, Jacklyn Nemunaitis, Sangeetha Prabhakaran, Nadja K. Falk
Breast Tall Cell Carcinoma With Reversed Polarity With An Unusual Molecular Profile, Kaitlyn J. Nielson, Edgar G. Fischer, Jacklyn Nemunaitis, Sangeetha Prabhakaran, Nadja K. Falk
Pathology Research and Scholarship
Breast tall cell carcinoma with reversed polarity (TCCRP) is rare and previously referred to as solid papillary carcinoma with reverse polarity. This low grade tumor commonly exhibits IDH2 p.Arg172 mutation, however is not completely understood at the molecular level. We present a case of TCCRP in a 55 year old woman with a 0.7 cm left breast mass. A core biopsy was performed with immunohistochemistry. Lumpectomy and sentinel lymph node biopsy were completed two months later. MammaPrint R© and BluePrint R© gene expression profilers were performed on an excision block. Microscopically, the tumor was composed of circumscribed nests of columnar …
Introduction To Neutrosophic Genetics, Florentin Smarandache
Introduction To Neutrosophic Genetics, Florentin Smarandache
Branch Mathematics and Statistics Faculty and Staff Publications
Neutrosophic Genetics is the study of genetics using neutrosophic logic, set, probability, statistics, measure and other neutrosophic tools and procedures. In this paper, based on the Neutrosophic Theory of Evolution (that includes degrees of Evolution, Neutrality (or Indeterminacy), and Involution) – as extension of Darwin’s Theory of Evolution, we show the applicability of neutrosophy in genetics, and we present within the frame of neutrosophic genetics the following concepts: neutrosophic mutation, neutrosophic speciation, and neutrosophic coevolution.
Role Of Β-Glucan Structure In Dectin-1 Homo- And Hetero-Oligomerization In Innate Anti-Fungal Immunity, Eduardo U. Anaya
Role Of Β-Glucan Structure In Dectin-1 Homo- And Hetero-Oligomerization In Innate Anti-Fungal Immunity, Eduardo U. Anaya
Biomedical Sciences ETDs
Dectin-1A is a C-type Lectin innate immunoreceptor that recognizes β-(1,3)-glucan, a structural component of Candida species cell walls. Dectin-1 has eight alternative splice isoforms including, A and B. Innate immunocytes can express one or both isoforms, but neither their relative responsiveness to β-glucan nor the potential for inter-isoform signaling cross-talk is well understood. In this study, we determine how the different structures of soluble β-glucans affect both isoforms and unravel how differences in glucan structure impact the earliest events in Dectin-1 signaling. Using quantitative microscopy techniques, we explored the role of glucan structure on Dectin-1A oligomerization, which is thought to …
Bystanders’ Perspectives On The Provision Of Informal, Hospital-Based Care To Bedridden Patients With Cancer In Sri Lanka, B. Sunil S. De Silva
Bystanders’ Perspectives On The Provision Of Informal, Hospital-Based Care To Bedridden Patients With Cancer In Sri Lanka, B. Sunil S. De Silva
Nursing ETDs
Due to the nursing shortage in Sri Lanka, patients need informal caregivers, known as bystanders, to help provide patient care. This study described bystanders’ perspectives on informal, hospital-based care to bedridden patients with cancer in Sri Lanka. In this qualitative descriptive study, 17 bystanders at Apeksa/Cancer Hospital, Sri Lanka, were recruited using snowballing sampling. Data were collected through telephone interviews and analyzed using content and thematic analyses. Findings showed that paid and unpaid bystanders cover all caregiving tasks with minimum interaction with nurses. Unpaid bystanders described the need for same-sex bystanders and additional help with patients’ mobilization and specialized care. …
Through The Funnel: A Critical Policy Analysis Of Educational Policy Relating To The School-To-Prison Pipeline., Jesse V. Hall
Through The Funnel: A Critical Policy Analysis Of Educational Policy Relating To The School-To-Prison Pipeline., Jesse V. Hall
Special Education ETDs
The purpose of the present study involved analyzing the policies of the Trump administration to determine the ways it impacted the school-to-prison pipeline. The focus of the study included the Departments of Education and Justice. The findings revealed educational policies and deregulatory practices that maintained and intensified the school-to-prison pipeline.
Neutrosophic Sets And Systems, Vol. 38, 2020, Florentin Smarandache, Mohamed Abdel-Basset, Said Broumi
Neutrosophic Sets And Systems, Vol. 38, 2020, Florentin Smarandache, Mohamed Abdel-Basset, Said Broumi
Neutrosophic Sets and Systems
No abstract provided.
Blockchain Risk Evaluation On Enterprise Systems Using An Intelligent Mcdm Based Model, Ahmed Abdel-Monem, Amal Abdel Gawad, Heba Rashad
Blockchain Risk Evaluation On Enterprise Systems Using An Intelligent Mcdm Based Model, Ahmed Abdel-Monem, Amal Abdel Gawad, Heba Rashad
Neutrosophic Sets and Systems
No abstract provided.
Index Of Documents Related To Fr. Vincent A. Lipinski, Hall & Monagle, Llc
Index Of Documents Related To Fr. Vincent A. Lipinski, Hall & Monagle, Llc
Records related to Fr. Vincent A. Lipinski
No abstract provided.
12-01-20 Hsc Committee Meeting Agenda, Hsc Committee
12-01-20 Hsc Committee Meeting Agenda, Hsc Committee
HSC Committee (A subcommittee of the UNM Board of Regents)
No abstract provided.
Neutrosophic Θ−Closure Operator, Md. Hanif Page, R. Dhavaseelan, B. Gunasekar
Neutrosophic Θ−Closure Operator, Md. Hanif Page, R. Dhavaseelan, B. Gunasekar
Neutrosophic Sets and Systems
No abstract provided.
On Deneutrosophication, Kanika Manda
On Deneutrosophication, Kanika Manda
Neutrosophic Sets and Systems
No abstract provided.