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20230331_Transgender Day Of Visibility, Varina Kosovich

HSLIC Blog Post

No abstract provided.

Depression Severity Relates To Lower Information Encoding In The Rewp Following High Positive-Affect Feedback, Garima Singh, Trevor Cj Jackson, Mark Lavelle, Darin R. Brown, James F. Cavanagh

Brain & Behavioral Health Research Day

The Reward Positivity (RewP) is a positive deflection in the EEG sensitive to reward receipt. Recent evidence suggests that the RewP is modulated by both reward probability as well as affective valuation (“liking”). We hypothesize that this latter “liking” feature is specifically affected in major depression. We recruited 69 participants (MDD =35, Control= 34) who completed a reinforcement learning task (green or red screen feedback) with concurrent affective images. We specifically examined the modulation of the RewP when paired with hedonically preferred images (puppies) vs. less-preferred images (cows). There was no group difference in “liking” ratings of puppy or cow …

Third-Wave Treatments For Impulsivity In Addictive Disorders: A Narrative Review Of The Active Ingredients And Overall Efficacy, David Ik Moniz-Lewis, Hannah A. Carlon, Hanna Hebden, Felicia R. Tuchman, Victoria R. Votaw, Elena R. Stein, Katie Witkiewitz

Brain & Behavioral Health Research Day

Purpose of Review: The goal of this review was to (1) synthesize recent studies that have examined impulsive behaviors in third-wave behavioral treatments, including Acceptance and Commitment Therapy, Mindfulness-Based Interventions, and Dialectical Behavior Therapy, and (2) examine the efficacy of these third-wave treatments in modifying impulsivity among individuals with addictive disorders.

Recent Findings: Recent studies indicate the potential for third-wave treatments in both treating addictive disorders and targeting the underlying neurocognitive mechanisms of impulsivity. Concerns around the conceptualization of impulsivity as a construct warrant the use of improved measurement of impulsive behaviors in future work.

Summary of Results: Through shared …

Apoptosis-Associated Speck-Like Protein Containing A Card (Asc) As A Potential Biomarker Of Dementia In Cerebrospinal Fluid, Kathryn Sánchez, Shanya Jiang, Sasha Hobson, Jeff E. Thompson, Sharina P. Desai, Gary A. Rosenberg, Kiran Bhaskar

Brain & Behavioral Health Research Day

Dementia impacts about fifty-five million individuals world-wide, and this number is expected to double every twenty years according to the World Health Organization. Though amyloid beta plaques and neurofibrillary tangles comprised of the hyperphosphorylated microtubule-associated protein tau are established hallmarks of dementia, inflammation is critical to its pathology. In a pathological state, microglia, which are the innate immune cells of the brain, assemble a multiprotein complex called the inflammasome. The inflammasome is composed of the NACHT, LRR, and PYD domain-containing protein 3 (NLRP3); the adaptor protein apoptosis-associated speck-like protein containing a CARD (ASC); and inflammatory caspase 1 (cysteine-dependent aspartate-directed protease …

Deficiency In Interleukin-1 Receptor Accessory Protein (Il-1rap) Alleviates Tau Pathology, Somayeh Dadras, Kiran Bhaskar

Brain & Behavioral Health Research Day

Neuroinflammation is associated with hyperphosphorylation and aggregation of tau, which results in the formation of neurofibrillary tangles in tauopathy brains. However, the precise mechanisms of how brain inflammation drives this process remains unclear. Previously, we have reported that tau pathology is induced in neurons through microglia-derived IL-1. It is unclear how IL-1 signaling is regulated in a cell-specific manner and at the receptor level. An important factor in IL-1/IL-1R1 signaling is IL-1 receptor accessory protein (IL-1RAP). In response to IL-1β, IL-1R1 engages IL-1RAP and activates NF-kB or p38 MAPK leading to downstream effects. In this study, we aimed to determine …

Prenatal Alcohol Exposure Exaggerates Nlrp3 Inflammasome-Dependent Immune Interactions Following Morphine Treatment That Paradoxically Increases The Chronicity Of Pathological Pain In Mice, A A. Pasmay, A A. Pritha, J R. Carter, M S. Sun, A Kf Oropeza, L Fauzi, D C. Jimenez, M Murphy, D D. Savage, C F. Valenzuela, E D. Milligan, S Noor

Brain & Behavioral Health Research Day

In utero alcohol exposure can lead to Fetal Alcohol Spectrum Disorder (FASD) which can result in a range of neurobehavioral deficits. Prenatal Alcohol exposure (PAE) can lead to chronic central nervous system (CNS) immune dysfunction during adulthood. Our prior work has demonstrated that adult PAE rat offspring with minimal nerve injury develop pathological light touch sensitivity or allodynia due to aberrant peripheral and spinal glial-immune interactions resulting in increased levels of pain inducing proinflammatory cytokine, IL-1β. We suspect that PAE-related adaptations may “prime” CNS glial-immune cells to over-respond to subtle immune challenges through innate immune receptors, TLR4 and Nod-like receptor …

Investigating Mechanisms Of Covid-19 Neuropsychological Dysfunction, Jude Chavez, Kevin Wilson, Karen Luo, Sarah Ward, Marcus Sterling, Adam Littleton, Ethan Campbell, John Romero, Richard Campbell, Darbi Gill, Jeremy Hogeveen, Jessica Richardson, David K. Quinn

Brain & Behavioral Health Research Day

Background Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is a highly pathogenic human coronavirus that typically causes respiratory infection. Evidence suggests that 10-15% of patients experience chronic neurologic symptoms, such as fatigue, headaches, and cognitive impairment.10 SARS-CoV-2 is thought to invade neural tissue, triggering immune system response, which may lead to brain dysfunction.7 The resulting brain dysfunction may be demonstrated through abnormal MRI and electroencephalography (EEG).4,8,9

Objective This study aims to establish foundational knowledge about the subacute and chronic neurocognitive effects of COVID-19, determine the pathologic mechanisms associated, and develop effective tools to guide and enhance treatment.

Hypothesis Neuro-positive COVID patients …

Enrichment-Mediated Neurogenesis Is Impaired In The Ventral Hippocampus In A Mouse Model Of Fetal Alcohol Spectrum Disorder (Fasd) And Potential Therapeutic Intervention, A M. Rodriguez, L Li, L A. Cunningham

Brain & Behavioral Health Research Day

Fetal alcohol spectrum disorder (FASD) is a leading cause of preventable intellectual disability and neural developmental disorders. Depression and anxiety are the most common mental illness in people with FASD. These disorders are related to ventral hippocampus function. The hippocampus is unique in its ability to produce new neurons throughout life. In fact, part of the therapeutic effect of some common antidepressants is to increase neurogenesis. Previous research conducted by our lab has shown that in a mouse model of FASD, enriched-environment (EE) mediated neurogenesis in the dorsal hippocampus is inhibited, this correlates with impaired pattern discrimination learning (Gustus et …

The Risk Analysis Index Has Superior Discrimination Compared To The Modified Frailty Index-5 In Predicting Worse Postoperative Outcomes For The Octogenarian Neurosurgical Patient, Alyssa Yocky, Oluwafemi Owodunni, Evan Courville, Syed Faraz Kazim, Meic Schmidt, Susan Gearhart, Naomi George, Diana Green-Chandos, Christian Bowers

Brain & Behavioral Health Research Day

Background

Healthcare systems continuously strive to improve quality and value of the care. Advances in surgical technologies, enhanced perioperative surgical planning, and multidisciplinary care strategies are increasing the number of elective procedures in the geriatric population. However, frail older adults are more still likely to have poor postoperative outcomes. We examined the discriminative thresholds for the risk analysis index (RAI), modified frailty index-5 (mFI-5) and increasing patient age for predicting adverse postoperative outcomes.

Methods

Octogenarian neurosurgery patients undergoing spine, cranial, and other procedures, captured in the ACS-NSQIP between 2012-2020 were included. We employed receiver operating characteristic (ROC) curve to examine …

The Effects Of Moderate Prenatal Alcohol Exposure On Navigation In A Delayed Non-Match-To-Place Spatial Alternation Task By Adult Male And Female Rats, Gabriela Acosta, Suzy Davies, Daniel D. Savage, Benjamin J. Clark

Brain & Behavioral Health Research Day

Prenatal Alcohol Exposure (PAE) has been found to result in structural alterations to regions of the brain involved in spatial memory, including the thalamus and hippocampus. Previous studies have shown that spatial memory is impaired after moderate PAE (mPAE; ~60-80 mg/dL) and damage to the limbic thalamus and hippocampus. Recent work has shown that visual-spatial discrimination memory is impaired after mPAE in a sex-specific manner such that female mice exhibit greater deficits after 15sec retention intervals. It is unclear whether similar-sex specific deficits would be observed in tests of spatial memory or in a rat model of mPAE. Thus, the …

Health Literacy Is Linked To Executive Functioning In Older American Indians, Alexis Burks, Anastacia Romero, Macaiah Shendo, Steven P. Verney

Brain & Behavioral Health Research Day

Objective: Health literacy (HL), the ability to understand healthcare information and navigate the healthcare system, is strongly associated with both educational achievement and executive functioning. Many American Indians (AIs) experienced traumatic early education, such as harsh boarding schools, which may impact their educational achievement, and subsequently, HL. Further, AIs disproportionately experience many chronic diseases. This study investigates the relationship between HL and executive functioning in older AIs.

Participants and Methods: Participants were recruited from a southwestern urban area who self-identified as AIs aged 55 to 80 (N=43). Participants were asked to complete questionnaires, interviews, and neuropsychological tests over two sessions. …

Cognitive Behavioral Therapy Is An Empirically Supported Treatment For Substance Use Disorder, Cassandra L. Boness, Victoria R. Votaw, Frank J. Schwebel, David Ik Moniz-Lewis, Kathryn Mchugh, Katie Witkiewitz

Brain & Behavioral Health Research Day

Cognitive behavioral therapy (CBT) is a commonly used treatment for a variety of substance use disorders (SUD) but has not been evaluated using the American Psychological Association’s “Tolin Criteria” which serves as the current standard for determining the empirical basis of psychological treatments. The current systematic review of reviews evaluated five meta-analyses of CBT for SUD. One meta-analysis had sufficient quality to be considered in the evaluation of effect sizes. CBT produced small to moderate effects on substance use, including quantity and frequency, when compared to inactive treatment and was most effective at early follow-up (1-6 months post-treatment; g_{range …}

Creating A Quality Of Life For People With Brain Injuries, Ken Collins

Brain & Behavioral Health Research Day

Ken Collins has lived with his brain injury for over 46 years and has worked with people with brain injuries and other disabilities to live independently since 1983: http://www.educationviews.org/ken-collins-reflections-recovery-head-injury/ He is an advocate of developing home and community-based services for people with brain injuries. In 1986-88 he was a VISTA Volunteer and helped develop the first independent living program for people with brain injuries in the U.S. http://www.sheltercare.org/2016/03/uhlhorn-beginnings/ Ken has participated in indigenous healing practices in the treatment of brain injury (Sweat Lodge, Hogan Ceremonies, NAC) and promotes the use of mindfulness-based stress reduction, Emotional Freedom Technique (EFT) tapping, Tai …

The Littlest Thinkers: Neonatal Cognitive Development Investigation Using Eeg, Katy Cody-Cavanagh, Aaron Cardon, Jessie Maxwell, Dawn Novak, Neurodiagnostics Lab

Brain & Behavioral Health Research Day

This is an ongoing research study investigating neonatal cognitive development using EEG (electroencephalogram) and auditory event-related potentials (AERPs). Very little is known about the cognitive brain development in neonates, and even less is known about neonates who have neurologic concerns, as they are often excluded from participation in other developmental studies. We used a non invasive and non participatory method for analyzing cognition by way of the mismatched negativity (MMN) event related potential. This is a cortically evoked electrophysiological response to the brain’s awareness of a change in auditory stimuli. The negative EEG deflection that occurs between 150-400ms after a …

Quality Of Education & Level Of Education In Association With Executive Functioning In Older American Indians, Eunice Kim, Alexis Burks, Katherine Edwards, Maria Mccready, Emily Kuehn, Jezreel Romero, Steven P. Verney

Brain & Behavioral Health Research Day

Objective: Level of educational achievement is often associated with executive functioning (EF) and overall health. However, education level does not account for the quality of education, which may be a better educational index for older American Indians (AIs). Many older AIs have suffered traumatic educational experiences, such as forced boarding schools and relocation focused on cultural assimilation rather than subject knowledge. This study investigated the relationship between EF and quality of education in older AIs.

Participants and Methods: Participants were recruited from a southwestern urban area who self-identified as AI aged 55 to 80 years (N=42). Participants completed questionnaires, interviews, …

Urine Anxiety Chronic Pain Model, Alexis Gravelle, Karin High, Sascha Alles, Marena Montera

Brain & Behavioral Health Research Day

Chronic stress is linked closely with mood disorders such as anxiety and depression. These behaviors can be measured to understand chronic pain more effectively. Previous studies have shown that similar pathways are used to treat both chronic pain and chronic anxiety. In this study a predatory stress model offers a non-physical pain stimulus as an avenue to invoke an anxiety response. To mimic a predatory situation, the behavior of BALB/c mice in response to regular exposure to coyote urine was analyzed. The use of a non-physical stressor elicits a similar response to the stress that an adult experiences daily. This …

Moderate Pae-Induced Deficits In Ltp And Glutamate Levels In The Dentate Gyrus: Enhancement In Ltp With The Histamine H3 Receptor Inverse Agonist Sar153954, Monica Goncalves-Garcia, Gabriela Acosta, Suzy Davies, Daniel D. Savage, D A. Hamilton

Brain & Behavioral Health Research Day

The hippocampus is susceptible to the effects of prenatal alcohol exposure (PAE) which can result in persistent cognitive impairments.

The hippocampus is susceptible to the effects of prenatal alcohol exposure (PAE) which can result in persistent cognitive impairments. Although there have been many investigations, deficits in synaptic plasticity remain poorly understood. Previous studies have identified deficits in long-term potentiation (LTP) in the perforant pathway(PP) to dentate gyrus synapses as a robust consequence of PAE. Currently, there are no known, clinically effective pharmacotherapeutic interventions for these deficits. This study sought to investigate the effects of PAE on the pre-synaptic mechanisms involved …

Striving Towards Universal Treatment: The Novel "Full Spectrum People-With-Opioid-Use-Disorder Care Model", Richard Gadomski, Snehal Bhatt, Jessica Gross, Tony Dixon, Phillip Fiuty, Max Sharpiro, Rafael Fernandez-Manacha, Julie Salvador

Brain & Behavioral Health Research Day

Background:

People with Opioid Use Disorder (PWOUD) represent an underserved and marginalized population. Low-barrier programs like mobile care units and street outreach programs have yielded increased access to buprenorphine and social services, however OUD pertinent co-occurring behavioral health and medical conditions are frequently left unaddressed. A novel, tailored, comprehensive care delivery model may reduce disparities and improve access to care across a range of pathologies in this historically difficult to reach population and enhance efforts to provide universal treatment access.

Methods:

Descriptive data was collected and analyzed regarding patient demographics, retention in treatment and services rendered at a new, wrap-around, …

A Novel Methodological Approach Of Collecting Mri In Newborns And Infants Without Sedation In A Multi-Site Consortium Pilot Study, Lidia Enriquez Marquez, Tracey Wick, Crystal Almeida, Alexandria Wiesel, Arvind Caprihan, Ludmila Bakhireva, Andrew R. Mayer

Brain & Behavioral Health Research Day

Background: The HEALthy Brain and Child Development (HBCD) is a multi-site research study (25 sites) designed to prospectively examine brain and behavioral development beginning prenatally through mid-childhood. The study will determine the impacts of a variety of risk and resilience environmental factors, including prenatal exposure to substances, from a diverse sample of pregnant individuals and their live-born children. The study incorporates repeated neuroimaging and neurophysiological measures (magnetic resonance imaging, MRI). One aspect of the HBCD pilot phase focuses on optimizing non-sedation techniques to facilitate MRI data acquisition in newborns (<1 month) and infants (≤9 months).

Methods: Concerted efforts were devoted to maximize scanning rates …

Effect Of Recorded Maternal Voice On Quantitative Eeg In The Preterm Newborn, Meghan Groghan, Aaron Cardon, Kate Cavanaugh, Dawn Novak

Brain & Behavioral Health Research Day

Background: Despite continued advances in quality medical care for premature infants, neurodevelopmental delay remains one of the most common complications of prematurity. It is also known that early diagnosis and intervention for developmental delays leads to improved outcomes. More recently, quantitative electroencephalogram (qEEG) has shown potential as a prognostic tool for identifying delays in preterm infants but remains an underutilized assessment. Maternal voice exposure has positive effects on autonomic stability and feeding vigor/tolerance in preterm infants. This novel study aims to investigate the effects of recorded maternal voice on qEEG patterns in preterm neonates.

Methods: Prospective, randomized, placebo-controlled clinical trial …

Comparison Of Right Vs Left Accelerated Resting-State Fmri-Guided Theta Burst Stimulation To The Dlpfc For Late-Life Depression: A Pilot Study, Jude Chavez, Karen Luo, Crystal Garcia, Christopher Abbott, Davin Quinn

Brain & Behavioral Health Research Day

Background: While trials of accelerated, neuronavigated repetitive transcranial magnetic stimulation (rTMS) to the left dorsolateral prefrontal cortex (DLPFC) for depression have shown efficacy for depression, there has not yet been validation of this technique for late-life depression (LLD). Additionally, no studies have tested accelerated intermittent theta burst stimulation (iTBS) to the right DLPFC for depression, although it may benefit depression and anxiety.

Methods: We enrolled 36 elderly patients (ages 50-79 years) with a diagnosis of pharmacoresistant depression of at least 6 months. Each participant received 45 sessions (5 treatments/day over 9 days) of iTBS to their functional MRI (fMRI) …

Center For Brain Recovery And Repair: Clinical Core, Rick Campbell, Michel Torbey, Kevin Wilson, Jude Chavez, Karen Luo, Sarah Ward, Marcus Sterling, Adam Littleton, Ethan Campbell, John Romero, Marcus Sterling, Darbi Gill, Davin Quinn, Jessica Richardson, Jeremy Hogeveen

Brain & Behavioral Health Research Day

The Center for Brain Recovery and Repair at the Health Sciences Center aims to develop safe and effective interventions targeted at specific pathways or mechanisms to improve the quality of life of New Mexicans with brain and behavioral conditions. The Center, part of the NIH IDeA program and funded as a Center of Biomedical Research Excellence, opened in 2015 in UNM Domenici Hall. In addition to creating a critical mass of investigators in the field of brain recovery and repair, the Center's facilities are also available for use by other investigators on a fee-for-service basis. The Center received Phase II …

Midbrain Degeneration And Cognition In Parkinson’S Disease, Kayla Julio, Stephanie Nitschke, Nicholas Shaff, Christopher Wertz, Andrew Mayer, Andrei Vakhtin, Gerson Suarez Cedeno, Amanda Deligtisch, Sarah Pirio Richardson, Sephira G. Ryman

Brain & Behavioral Health Research Day

Neuromelanin imaging is an emerging biomarker for PD as it captures degeneration of the midbrain. Currently, it is unknown whether this degeneration contributes to cognitive dysfunction in PD beyond dysfunction associated with fronto-subcortical systems. Here, we examine whether neuromelanin signal is associated with broader cognitive dysfunction in PD patients with varying degrees of cognitive impairment: PD with normal cognition (PD-NC), PD with mild cognitive impairment (PD-MCI), and healthy controls (HC).

12 PD-NC, 18 PD-MCI and 19 HC underwent an MRI scan that included a neuromelanin-sensitive (NM-MRI) sequence. Contrast-to-noise-ratio of the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) …

Comparison Of Novel Virus-Like Particle Vaccines Against Tau In A Mouse Model Of Alzheimer’S Disease, Jonathan Hulse, Nicole Maphis, Julianne Peabody, Bryce Chackerian, Kiran Bhaskar

Brain & Behavioral Health Research Day

Alzheimer’s disease (AD) is characterized by the accumulation of tau tangles and amyloid-β plaques in the brain with accompanied neurodegeneration. Phosphorylation of tau at specific sites occurs early in the disease process and has been shown to drive tau pathology which correlates with disease progression. Promoting the clearance of pathological tau may be a useful therapeutic strategy. Previously, we developed Qβ bacteriophage virus-like particle (VLP) vaccines displaying phosphorylated Thr181 tau peptides that promoted robust immune response, tau clearance, and improved memory. Here we report characterization and comparison of a Qβ-PHF-1-VLP and a Qβ-AT8-VLP vaccine. Transgenic rTg4510 mice were administered three …

Altered Neuronal Firing Following A Spreading Depolarization: An In Vivo Study, Branki R. Hess, Natalie J. Pinkowski, Carissa J. Mehos, Betty Fish, Russell A. Morton

Brain & Behavioral Health Research Day

Spreading Depolarizations (SD) are slowly propagating waves of tissue depolarization that result in the suppression of neuronal firing for multiple minutes. SDs are known to occur in rodents suffering from moderate or severe traumatic brain injuries and are also associated with visual auras that often-proceeded migraines. Our previous work established that SDs initiate in a closed skull concussion model in mice. The presence of SDs in our injury model is tightly associated with acute behavioral deficits that last hours. The behavioral deficits are attributed to neurological impairment, but a mechanistic understanding of that impairment remains unclear. We hypothesize that there …

Preliminary Psychometric Testing Of The Treatment Self-Regulation Questionnaire For Assessing Motivations For Responsible Cannabis Use: An Application Of Self-Determination Theory, Haydee Andujo, Jakub D. Gren, Joey C. Mok, Ricardo A. Rubio, Dylan K. Richards, Matthew R. Pearson, Addictions Research Team

Brain & Behavioral Health Research Day

Cannabis use protective behavioral strategies (PBS) are cognitive–behavioral strategies used before, during, and/or after cannabis use to reduce cannabis use and related problems. Self-determination theory (SDT) provides a potentially useful framework to understand motivations for responsible cannabis use, which is operationalized in the present study as PBS use. In the present study, we examined the relation of motivations for responsible cannabis use, as assessed by the 15-item Treatment Self-Regulation Questionnaire (TSRQ), with cannabis PBS use and other cannabis-related outcomes. A sample of 408 past month cannabis users were recruited from a multisite study of college students (n=1856). Consistent with SDT …

Neurodevelopmental Outcomes For Children Participating In Navajo Birth Cohort Study (Nbcs), Heather Krapf, Brandon Rennie, Nbcs Team

Brain & Behavioral Health Research Day

Background: There are many (>500) abandoned mines on Navajo Nation with lots of families living within a short distance (within 10 km) of an abandoned site. Research has indicated higher concentrations of heavy metals among many individuals on Navajo Nation. The Environmental Influences on Child Health Outcomes (ECHO), a seven-year initiative funded by the National Institute of Health (NIH), allowed us to build on the Navajo Birth Cohort Study (NBCS) and continue to follow-up with existing participants. A main aim of NBCS/ECHO has been to examine the effects of environmental exposures such as heavy metals on childhood developmental outcomes. …

Comparison Of Stereoelectroencephalography Versus Subdural Electrodes For Invasive Epilepsy Monitoring In Pediatric Patients: A Meta-Aaalysis, Syed Faraz Kazim, Michael Kogan, James A. Botros, Ariana Barkley, Heather Stevens Spader

Brain & Behavioral Health Research Day

Introduction: Stereoelectroencephalography (SEEG) and subdural explorations (SDE, including grids, strips, and depth electrodes) represent the two main techniques utilized in pre-operative evaluation of medically refractory epilepsy. During the past two decades, some studies have explored the comparative safety and effectiveness of these two modalities in pediatric patients.

Methods: We conducted a systematic review with meta-analysis following PRISMA guidelines. We performed literature search using MeSH terms published until June 30, 2022 in four electronic databases. The R statistical software version 3.5.3 and MedCalc Statistical Software version 19.2.3 were used to perform the meta-analysis.

Results: We included 16 studies with 780 pediatric …

Preoperative Frailty Measured By Risk Analysis Index Predicts Complications And Poor Discharge Outcomes After Brain Tumor Resection In A Large Multi-Center Analysis, Syed Faraz Kazim, Rachel Thommen, Kavelin Rumalla, Alexander J. Kassicieh, Piyush Kalakoti, Meic H. Schmidt, Rohini G. Mckee, Daniel E. Hall, Christian A. Bowers

Brain & Behavioral Health Research Day

Background

To evaluate the independent effect of frailty, as measured by the Risk Analysis Index-Administrative (RAI-A) for postoperative complications and discharge outcomes following brain tumor resection (BTR) in a large multi-center analysis.

Methods

Patients undergoing BTR were queried from the National Surgical Quality Improvement Program (NSIQP) for the years 2015 to 2019. Multivariable logistic regression was performed to evaluate the independent associations between frailty tools (age, 5-factor modified frailty score [mFI-5], and RAI-A) on postoperative complications and discharge outcomes.

Results

We identified 30,951 patients who underwent craniotomy for BTR; the median age of our study sample was 59 (IQR 47–68) …

Age-Specific Prognostic Hub Genes Associated With Immune Cell Infiltration In Glioblastoma Multiforme: An Analysis Of Tcga Data, Syed Faraz Kazim, Devin W. Vidrine, Meic H. Schmidt, Christian A. Bowers

Brain & Behavioral Health Research Day

Introduction

Glioblastoma multiforme (GBM) is the most common malignant brain tumor and carries a poor prognosis with median survival time (MST) of approximately 18-20 months. Increasing evidence has revealed that infiltrating immune cells and other stromal components in the tumor microenvironment (TME) are associated with prognosis of GBM. The present study was conducted to identify age group-specific prognostic hub genes associated immune cell infiltration in GBM patients.

Methods

We extracted clinical and gene expression data [based on RNA-Sequencing (RNA-Seq) and microarray] of 593 primary GBM patients from The Cancer Genome Atlas (TCGA) (www.cancergenome.nih.gov). For analysis, the data was distributed into …