Digital Commons Network^™

04-07-23 Hsc Committee Agenda, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Genomic Disorders In Ckd Across The Lifespan, Miguel Verbitsky, Sarathbabu Krishnamurthy, Priya Krithivasan, Daniel Hughes, Atlas Khan, Maddalena Marasà, Natalie Vena, Pavan Khosla, Junying Zhang, Tze Y. Lim, Joseph T. Glessner, Chunhua Weng, Ning Shang, Yufeng Shen, George Hripcsak, Hakon Hakonarson, Iuliana Ionita-Laza, Brynn Levy, Eimear E. Kenny, Ruth J F Loos, Krzysztof Kiryluk, Simone Sanna-Cherchi, David R. Crosslin, Susan Furth, Bradley A. Warady, Robert P. Igo, Sudha K. Iyengar, Craig S. Wong, Afshin Parsa, Harold I. Feldman, Ali G. Gharavi

Pediatrics Research and Scholarship

SIGNIFICANCE STATEMENT: Pathogenic structural genetic variants, also known as genomic disorders, have been associated with pediatric CKD. This study extends those results across the lifespan, with genomic disorders enriched in both pediatric and adult patients compared with controls. In the Chronic Renal Insufficiency Cohort study, genomic disorders were also associated with lower serum Mg, lower educational performance, and a higher risk of death. A phenome-wide association study confirmed the link between kidney disease and genomic disorders in an unbiased way. Systematic detection of genomic disorders can provide a molecular diagnosis and refine prediction of risk and prognosis.

BACKGROUND: Genomic disorders …

Gender Analysis Of Journal Of Perinatology Authorship During Covid-19, Lauren Gadek, Christiane Dammann, Renate Savich, Christiana Mmuo-Oji, Leonardo Barrera, Patrick G. Gallagher, Kerri Machut

Pediatrics Research and Scholarship

OBJECTIVE: To examine authorship gender distributions before and during COVID-19 in the Journal of Perinatology.

STUDY DESIGN: We collected data from the Journal of Perinatology website. The author gender was determined using Genderize.io or a systematic internet search. Our primary outcome was the difference between the number of published articles authored by women during the pandemic period (March 2020-May 2021, period two), compared with the preceding 15-month period (period one). We analyzed the data using chi-square tests.

RESULTS: Publications increased from period one to two by 8.9%. There were slightly more female than male first (62%) and overall (53%) authors, …

The Midas Touch: Atuahene's "Stategraft" And Unregulated Artificial Intelligence, Sonia Gipson Rankin

Faculty Scholarship

Professor Bernadette Atuahene’s article, A Theory of Stategraft, develops the new theoretical conception of “stategraft.” Professor Atuahene notes that when state agents have engaged in practices of transferring property from persons to the state in violation of the state’s own laws or basic human rights, it sits at the nexus of illegal behavior and revenue-generating activity for the government. Although there are countless instances of “stategraft,” one particularly salient example is when the state uses artificial intelligence to illegally extract resources from people. This Essay will apply stategraft to an algorithm implemented in Michigan that falsely accused recipients of unemployment …

Civil Procedure Update 2023, Julio C. Romero, Verónica C. Gonzales

Faculty Scholarship

This presentation aims to 1) review recent amendments to the state and federal rules of civil procedure; 2) help you understand the impact of recent federal and state published opinions interpreting and applying the rules of civil procedure; and 3) assess your understanding of the updates.

A Clean Catch, Carl M. Beranek, Lynne Fullerton

Quality Improvement/Patient Safety Symposium

Improving Quality of Urinalysis Samples Collected in the Emergency Department

Carl Beranek, MD, Lynne Fullerton, PhD

Problem (Gap) Identification/Background:

Urine samples with greater than five squamous cells are of low diagnostic value as they are considered contaminated. Sending contaminated samples to lab wastes time and resources and delays care of all patients. The current literature is mixed on utility of supplemental instructions improving contamination frequency of urinalysis (UA). A published study has demonstrated illustrations improved UA quality in female populations. Another study demonstrated that a mobile application did not. A third study demonstrated written instructions did not improve quality of …

Oropharyngeal Therapy With Breastmilk In Premature Neonates And Its Implications For Neonatal Outcomes, Asma Qamruddin

Quality Improvement/Patient Safety Symposium

Title: Oropharyngeal Therapy with Breastmilk in Premature Neonates and its Implications for Neonatal Outcomes

Authors: Asma Qamruddin MD, and Kevin P Vlahovich MD MS

Background: Breastmilk contains protective immune factors which are antimicrobial, immunomodulatory, and pro-maturational. Early oropharyngeal therapy (OPT) with breastmilk helps to stimulate a neonate’s innate immune system which could potentially decrease the risk of infection and feeding intolerance in premature infants. We examined and compared the neonatal outcomes with or without OPT.

Intervention Description: This was a quasi-experimental study conducted at Advocate Children's Hospital Illinois. Infants born(n =56 infants) and those from June 2020 to November 2020 …

Pathology Education Powered By Virtual And Digital Transformation: Now And The Future, Lewis A. Hassell, Syeda Fatima Absar, Chhavi Chauhan, Suzanne Dintzis, Carol Farver, Samreen Fathima, Eric F. Glassy, Jeffery F. Goldstein, Rama Gullapalli, Jonhan Ho, Lisa K. Koch, James E. Madory, Kamran M. Mirza, Phuong Nhat Nguyen, Liron Pantanowitz, Anil Parwani, Rebecca Rojansky, Robert P. Seifert, Rajendra Singh, Ehab A. Elgabry, Marilyn Bui

Pathology Research and Scholarship

CONTEXT.—: Myriad forces are changing teaching and learning strategies throughout all stages and types of pathology education. Pathology educators and learners face the challenge of adapting to and adopting new methods and tools. The digital pathology transformation and the associated educational ecosystem are major factors in this setting of change.

OBJECTIVE.—: To identify and collect resources, tools, and examples of educational innovations involving digital pathology that are valuable to pathology learners and teachers at each phase of professional development.

DATA SOURCES.—: Sources were a literature review and the personal experience of authors and educators.

CONCLUSIONS.—: High-quality digital pathology tools and …

Transferrin Receptor-Mediated Iron Uptake Promotes Colon Tumorigenesis, Hyeoncheol Kim, Luke B. Villareal, Zhaoli Liu, Mohammad Haneef, Daniel M. Falcon, David R. Martin, Ho-Joon Lee, Michael K. Dame, Durga Attili, Ying Chen, James Varani, Jason R. Spence, Olga Kovbasnjuk, Justin A. Colacino, Costas A. Lyssiotis, Henry C. Lin, Yatrik M. Shah, Xiang Xue

Pathology Research and Scholarship

Transferrin receptor (TFRC) is the major mediator for iron entry into a cell. Under excessive iron conditions, TFRC is expected to be reduced to lower iron uptake and toxicity. However, the mechanism whereby TFRC expression is maintained at high levels in iron-enriched cancer cells and the contribution of TFRC to cancer development are enigmatic. Here the work shows TFRC is induced by adenomatous polyposis coli (APC) gene loss-driven β-catenin activation in colorectal cancer, whereas TFRC-mediated intratumoral iron accumulation potentiates β-catenin signaling by directly enhancing the activity of tankyrase. Disruption of TFRC leads to a reduction of colonic iron levels and …

Nanoscience & Microsystems Engineering Apr Spring 2023 Self-Study Report & Documents, Unm Academic Program Review

UNM Academic Program Review

Nanoscience and Microsystems Engineering APR self-study report, review team report, response report, and initial action plan for Spring 2023, fulfilling requirements of the Higher Learning Commission.

Native American Studies 2023 Apr Self-Study & Documents, Unm Academic Program Review

UNM Academic Program Review

UNM Native American Studies APR self-study report and review team report for Spring 2023, fulfilling requirements of the Higher Learning Commission

University College 2023 Apr Self-Study & Documents, Unm Academic Program Review

UNM Academic Program Review

UNM University College APR self-study report and review team report for Spring 2023, fulfilling requirements of the Higher Learning Commission.

University College Apr Spring 2023 Self-Study Report & Documents, Unm Academic Program Review

UNM Academic Program Review

University College APR self-study report, review team report, response report, and initial action plan for Spring 2022, fulfilling requirements of the Higher Learning Commission. UC includes the following: Liberal Arts & Integrative Studies, ROTC, Academic Communities, and Pre-Health Professions.

Native American Studies Apr 2023 Self-Study Report & Documents, Unm Academic Program Review

UNM Academic Program Review

Native American Studies APR self-study report, review team report, response report, and initial action plan for Spring 2022, fulfilling requirements of the Higher Learning Commission.

Nanoscience And Microsystems Engineering 2023 Apr Self-Study & Documents, Unm Academic Program Review

UNM Academic Program Review

UNM Nanoscience & Microsystems Engineering APR self-study report and review team report for Spring 2023, fulfilling requirements of the Higher Learning Commission.

Biochemistry Apr 2023 Self-Study Report & Documents, Unm Academic Program Review

UNM Academic Program Review

Biochemistry APR self-study report, review team report, response report, and initial action plan for Spring 2023, fulfilling requirements of the Higher Learning Commission.

Biochemistry 2023 Apr Self-Study & Documents, Unm Academic Program Review

UNM Academic Program Review

UNM Biochemistry APR self-study report and review team report for Spring 2023, fulfilling requirements of the Higher Learning Commision

Genomic Disorders In Ckd Across The Lifespan, Miguel Verbitsky, Sarathbabu Krishnamurthy, Priya Krithivasan, Daniel Hughes, Atlas Khan, Maddalena Marasà, Natalie Vena, Pavan Khosla, Junying Zhang, Tze Y. Lim, Joseph T. Glessner, Chunhua Weng, Ning Shang, Yufeng Shen, George Hripcsak, Hakon Hakonarson, Iuliana Ionita-Laza, Brynn Levy, Eimear E. Kenny, Ruth Jf Loos, Krzysztof Kiryluk, Simone Sanna-Cherchi, David R. Crosslin, Susan Furth, Bradley A. Warady, Robert P. Igo, Sudha K. Iyengar, Craig S. Wong, Afshin Parsa, Harold I. Feldman, Ali G. Gharavi

Pediatrics Research and Scholarship

SIGNIFICANCE STATEMENT: Pathogenic structural genetic variants, also known as genomic disorders, have been associated with pediatric CKD. This study extends those results across the lifespan, with genomic disorders enriched in both pediatric and adult patients compared with controls. In the Chronic Renal Insufficiency Cohort study, genomic disorders were also associated with lower serum Mg, lower educational performance, and a higher risk of death. A phenome-wide association study confirmed the link between kidney disease and genomic disorders in an unbiased way. Systematic detection of genomic disorders can provide a molecular diagnosis and refine prediction of risk and prognosis.

BACKGROUND: Genomic disorders …

The Role Of Citizen Science In Ecosystem Management: A Case Study Of The Middle Rio Grande Bosque Ecosystem Monitoring Program, Hannah Miller

Water Resources Professional Project Reports

Rapid advances in technology, especially smart phones, have changed citizen science around the world. Citizen science-generated data are growing exponentially, so there is increasing interest about what is happening with all this data. Some research suggests that governmental agencies are not using citizen science data to make ecosystem management decisions, although other studies contradict this finding. Regionally, the Middle Rio Grande bosque ecosystem extends for 162 miles along the Rio Grande in New Mexico. The Bosque Ecosystem Monitoring Program, or BEMP, was founded in 1996 following the efforts of the Bosque Initiative and the development of the Bosque Biological Management …

Performance Of The Mineral Recovery Enhanced Desalination Pilot Water Treatment Plant, Samantha Valentine

Water Resources Professional Project Reports

There is a growing interest in treating brackish groundwater to supplement freshwater resources for inland communities in arid climates. Water recovery by desalination of brackish groundwater is challenging due to mineral scaling from ions which form carbonate and sulfate minerals, dissolved silica which forms silicates, iron, manganese, and other constituents along with the difficulties and cost of disposing of large volumes of brine from the desalination process. The MRED process consists of a pretreatment process to increase water recovery and decrease waste production from brackish groundwater. The MRED process uses a unique sequence of unit processes consisting of: (1) Air …

Rural Water Manager Challenges In New Mexico, Amy "Aj" Jones

Water Resources Professional Project Reports

New Mexico poses a valuable set of circumstances to study the challenges faced by drinking water systems. A general lack of resources for small systems, be it personnel and funding issues, lack of community engagement, lack or loss of institutional knowledge, ability to meet regulations, and aging managers were found to be very common and widespread. Rural water manager positions that are unsupported financially do not assist in alleviating rural poverty or draw the workforce. Therefore, the negative state demographic statistics are reinforced, further complicating rural water management rather than helping the issues. To look at drinking water management comprehensively, …

Securing Environmental Flows For The Rio Grande Silvery Minnow, Ashley Veihl

Water Resources Professional Project Reports

Since 1997, the Bureau of Reclamation (Bureau) has been leasing water to provide habitat for the now-endangered Rio Grande silvery minnow (Minnow). The majority of leased water comes from the San-Juan Chama project, a trans-basin water delivery system that was originally implemented to secure flows to the Rio Grande for municipal and agricultural use. Limitations on water storage within reservoirs incentivize contractors that are allocated more surface water than they can use to lease the extra quantity. It is through this water leasing market that the Bureau has established the largest environmental flow program in the state of New Mexico. …

Examination Of Self-Determination Theory-Based Motivations For Using Cannabis Responsibly And Cannabis Use Motives As Predictors Of Cannabis-Related Outcomes Among College Students, Ricardo A. Rubio, Jakub D. Gren, Joey C. Mok, Haydee Andujo, Dylan K. Richards, Matthew R. Pearson, Addictions Research Team

Brain & Behavioral Health Research Day

Cannabis use motives, or reasons people choose to use cannabis, are well-established risk factors for cannabis use and related negative consequences and include (in order of most to least risky) using cannabis to reduce negative affect (coping motives), increase positive affect (enhancement motives), to avoid negative social experiences (conformity motives), to enhance social experiences (social motives), and to expand one’s experiences (expansion motives). Our current research also examines motivations to use cannabis responsibly based on self-determination theory (SDT), which includes (in order of most to least protective) consciously valuing responsible use (autonomous motivation), seeking/avoiding internal rewards/punishments (introjected regulation), seeking/avoiding external …

Observed Differences In Goal-Directed Actions Among Individuals Affected By Covid-19, Jude Chavez, Kevin Wilson, Karen Luo, Sarah Ward, John Romero, Ethan Campbell, Darbi Gill, Richard Campbell, Jeremy Hogeveen, Jessica Richardson, Davin Quinn

Brain & Behavioral Health Research Day

The neurological complications of COVID-19 are fearsome and not understood Ischemic strokes, meningo-encephalitis, peripheral nerve damage, agitated delirium, dysosmia, and psychiatric disturbances have all been extensively documented. SARS-CoV-2 appears to directly invade neural tissue and triggers states of hypercoagulability, immune system activation, and hypoxemia, all of which contribute to severe brain dysfunction and possible damage in the acute phase. The motivation to initiate action is central to adaptive functioning but is impaired in a variety of neurological and psychiatric disorders. In particular, a significant number of patients with traumatic brain injury (TBI) demonstrate clinically-significant apathy - i.e., a negative change …

Identifying Profiles Of Cannabis Users Based On Their Motivations To Use Cannabis Responsibly: An Application Of Self-Determination Theory, Joey C. Mok, Jakub D. Gren, Haydee Andujo, Ricardo A. Rubio, Dylan K. Richards, Matthew R. Pearson, Addictions Research Team

Brain & Behavioral Health Research Day

Based on self-determination theory (SDT), motivation can be understood as existing on a continuum from the most to the least self-determined (autonomous motivation, introjected regulation, external regulation, amotivation) with more self-determined motivations associated with positive health outcomes, and less self-determined motivations associated with negative health outcomes. Using a newly developed measure of motivations to use cannabis responsibly (TRSQ), we sought to identify unique subpopulations of cannabis users based on their motivations to use (or not use) cannabis use responsibly, positing that those with more self-determined motivations would report higher use of cannabis protective behavioral strategies (PBS) and lower cannabis use/problems. …

A Bacteriophage Virus-Like Particle Vaccine Against Heroin Generates Protective Antibody Responses, Isabella G. Romano, Brandi Johnson-Weaver, Herman Staats, Bryce Chackerian, Kathryn M. Frietze

Brain & Behavioral Health Research Day

Opioid use disorder (OUD) and opioid overdose are urgent public health crises, with opioid overdose rates tripling within the last decade in the United States. Current treatments have limited efficacy, and challenges associated with implementation. Vaccines against opioids have recently been proposed as novel treatments, with some vaccine strategies showing promising pre-clinical data. Here, we report our efforts to engineer a vaccine against heroin that elicits high-titer and long-lasting antibodies with protective functionality. We utilized bacteriophage Qβ virus-like particles (VLPs) to display drug targets in a highly immunogenic and multivalent format. The active metabolites of heroin, morphine and 6-aceyl-morphine, were …

Syllable Diadochokinesis In Professional Boxers And Mixed Martial Artists, Amy Neel, Ninel Hernandez, Jessica Richardson, Lauren Bennett, Sarah Banks, Aaron Ritter, Charles Bernick

Brain & Behavioral Health Research Day

Background: Recent studies in our laboratory have documented slower speech rates in passage readings for boxers and mixed martial artists (MMAs) compared to healthy controls. Diadochokinetic rate tasks (DDK), where syllables are repeated as quickly as possible, more directly measure speech motor abilities than reading or spontaneous speech tasks (e.g., less cognitive/linguistic confounds). We investigated DDK rates for professional boxers, MMAs, and controls with no history of RHI.

Methods: Participants were 27 professional boxers, 37 professional MMA fighters, and 30 controls ranging in age from 20 to 77 years of age from the Professional Athletes Brain Health Study. They were …

Continuous Cerebral Autoregulation Measurement And Outcomes In Aneurysmal Subarachnoid Hemorrhage, Masoom Desai, Ali Alsarah, Thomas Jones, Bert Davis, Chad Cole, Andrew P. Carlson

Brain & Behavioral Health Research Day

Background:

Impaired cerebral autoregulation has been associated with worse outcomes in patients with aneurysmal subarachnoid hemorrhage (aSAH). Recent data demonstrated that oxygen reactivity measured by either parenchymal probes or near infrared spectroscopy (NIRS) may be associated with worse clinical outcomes and occurrence of spreading depolarization events.

Methods:

We prospectively collected continuous multimodality monitoring recordings in patients with aneurysmal treated at our institution between 2011 and 2021. Physiologic data were linked using the Moberg Component Neuromonitoring system (CNS) and clinical data were obtained by chart review. Continuous autoregulation indices were calculated using the CNS Envision software retrospectively for all available data …

An Alarming Interloper: A Case Report Of Capgras Syndrome As Presentation Of C9orf72-Associated Frontotemporal Dementia, Christine Meadows, Monika Manchanda, Jonathan Cauchi

Brain & Behavioral Health Research Day

Introduction: Mutations in the hexanucleotide repeat expansion in the C9orf72 gene are associated with frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Diagnosis is challenging due to highly variable penetrance. This case report describes a rare manifestation of C9orf72 associated-FTD that presented as Capgras delusion.

Case: This is a case of a 77-year-old male with no diagnosed medical history who was admitted to an inpatient psychiatric facility due to delusions that his wife had been replaced by an imposter. MRI of the brain revealed symmetric mild to moderate cortical atrophy. Patient had an extensive family history of FTD and ALS …

"It's All In Your Head": Abnormal Visual Processing During Magnetoencephalography Is Associated With Mild Traumatic Brain Injury In Us Veterans, David Quinn, Megan Schendel, Adam Littleton, Marcus Sterling, Joel Upston, Thomas Jones, Lindsay Worth, Kevin Wilson, Jude Chavez, Jessica Richardson, Chang Yaramothu, Tara Alvarez, Michael Hoffer, Stacey Harris-Carriman, Andrew Mayer, Julia Stephen

Brain & Behavioral Health Research Day

No abstract provided.