Digital Commons Network^™

Ctsc Clinical And Translational Research Experience (Ct-Rex) Program, Regis Lacher, Annette Crisanti

Brain & Behavioral Health Research Day

There is a workforce shortage in Clinical Research Professionals (CRPs. e.g., study coordinators, data management specialists) with a widening gap between supply and demand. The “great resignation” has exacerbated this problem with current resignation rates among CRPs 60% higher than in 2020. Research on this workforce shows that for every one qualified Clinical Research Coordinator, there are seven job postings. The ratio for Clinical Research Nurses is 1:10 and the ratio for Regulatory Affairs Professionals is 1:35. Furthermore, the US job market for CRPs is predicted to grow by 10% between 2016 and 2026. In terms of consequences, the CRPs …

Traumatic Brain Injury And Psychopathic Traits In Justice-Involved Adult Males, Michaela M. Milillo, Tessa Cappelle, Gerard J.B Clarke, Craig S. Neumann, J Michael Maurer, Nathaniel Anderson, Carla L. Harenski, David Arciniegas, Jean Decety, Michael Koenigs, Kent A. Kiehl

Brain & Behavioral Health Research Day

This is an original study that investigates correlates of traumatic brain injury (TBI; i.e., severity, total number of TBIs, age at first TBI) and psychopathic traits (i.e., antisocial or interpersonal qualities) in justice-involved adult males who were incarcerated at the time of their participation. Our results show higher levels of psychopathic traits in individuals with TBI versus those without, which suggests a greater need to target TBI in the treatment of justice-involved populations.

FUNDING This work was supported by grants from the National Institutes of Health (R01MH109329 R01DA026964, R01DA026505, R01MH071896, R01DA020870, R01MH070539; PI: Kent A. Kiehl, Ph.D.).

Recognizing Strokes In The Pacu In Adult Versus Pediatric Patients, Juliet Velhagen, Thomas Ferrer, Ricardo Falcon, Tim Petersen, Codruta Soneru

Brain & Behavioral Health Research Day

This poster discusses strokes in the post-anesthesia care unit in both adult and pediatric patients. We discuss stroke incidence, post-anesthesia stroke symptoms to be aware of, what symptoms overlap between adult and pediatric patients, and the importance of early stroke recognition.

Peer Support Model To Address Substance Use Disorders Treatment Engagement In Rural Communities, Justine L. Saavedra, Lucia E. Martinez, Annette Crisanti, Sttep Research Group

Brain & Behavioral Health Research Day

New Mexico consistently leads the nation in alcohol-related and drug overdose deaths. In an attempt to reduce the consequences of substance use disorder (SUD), a telehealth-SUD treatment program is being implemented at Sandoval Regional Medical Center to reach underserved rural communities. Peer Support Workers (PSWs) deliver culturally informed treatment and medical professionals provide medication addiction treatment. Data on participant outcomes and preliminary costs associated with peer delivered TH-SUD treatment are currently being collected.

Funding: Research reported in this presentation was supported by Congressionally Delegated funds administered by the Substance Abuse and Mental Health Services Administration (SAMHSA) Award Number 1H79FG000817-01.

Sphingosine-1-Phosphate Receptor 1 Agonist Sew2871 Reduces Bbb Dysfunction And Improves The Cognitive Impairment Associated With Cerebral Small Vessel Disease, Bushra Shal, Michael Griego, Yirong Yang, Laurel Sillerud, Carlos Perez, Joanna Mcchriston, Haoran Deng, Haojie Chen, Yi Yang

Brain & Behavioral Health Research Day

Cerebral small vessel disease (SVD) involves vascular pathological processes under hypoxic hypoperfusion that contributes to the endothelial dysfunction resulting in blood brain barrier (BBB) damage, brain white and grey matter lesions, and vascular cognitive impairment. We previously reported that activation of sphingosine-1-phosphate receptor 1 (S1PR1), using a selective S1PR1 agonist, SEW2871 (SEW) reversed the loss of BBB integrity. This study investigated the different doses of SEW2871, a S1PR1 agonist against neuropathological cascades involved in SVD.

FUNDING: This study is supported by a NIH/NINDS grant (1RF1NS110724) to Dr. Yi Yang

A Review On The Diagnostic Utility Of Artificial Intelligence In Psychology, Serena Smith, Eunice Kim

Brain & Behavioral Health Research Day

Artificial Intelligence (AI) has been increasingly integrated into clinical and neuroscientific research methods over the last decade, expanding on methods and results while raising ethical concerns. Concerns about patient privacy, scientific and clinical validity, neuro-discrimination, and anthropomorphism have been evaluated in the literature (Salles, et al., 2020, Ienca and Ignatiadis, 2020, Timmons, et al., 2022). A literature review was conducted to evaluate the potential benefits as well as the potential concerns associated with recent AI developments over the last 5 years in the fields of neuroscience and psychology. 30 articles were reviewed using Google Scholar and PubMed. Search terms included …

Longitudinal Trajectories Of Ptsd Severity And Associations With Risk And Protective Factors Among Recently Resettled Refugees In The United States, David Lardier, Meredith A. Blackwell, Jessica R. Goodkind

Brain & Behavioral Health Research Day

Refugees are at risk of experiencing emotional distress due to exposure to traumatic events. Less is known about the etiological trajectories of these mental health symptoms. This study conducted secondary data analyses from a longitudinal RCT testing an intervention among 290 refugees from 148 households. The primary purpose of the current study was to identify distinct longitudinal subgroup trajectories based on participant PTSD severity among refugees as well as factors influencing latent class group membership.

Pilot-Testing A Vascular Risk Factor Reduction Intervention For Adults With Post Stroke Executive Dysfunction: Champs, Suzanne Burns, Tim Dionne, Jude Chavez, Karen Lou, Binh T. Nguyen, Sarah K. Ward, Kevin Wilson, Davin Quinn, Jessica Richardson

Brain & Behavioral Health Research Day

Non-Expert Summary: People with stroke are at an increased risk for recurrent stroke, heart disease, cognitive decline, and general decline in health and function after returning to community living. This poster describes the protocol and study progress for a pilot intervention project that is designed to provide metacognitive strategy training and vascular risk factor reduction education in people with stroke and residual cognitive deficits like executive dysfunction.

Examining Substance Use And Mental Health Patterns Among Hispanic Adolescents: A Latent Class Analysis And Its Associations With Risk And Protective Factors, Carolina Verdezoto, David Lardier, Pauline Garcia-Reed, Robert J. Reid

Brain & Behavioral Health Research Day

Concurrent substance use and comorbid mental health issues tend to be correlated with numerous socioecological indicators (e.g., community violence exposure; low community connectedness) as well as both interpersonal (e.g., family relationships) and intrapersonal (e.g. perceived empowerment) experiences. The purpose of this study was to examine alcohol and concurrent drug use patterns among Hispanic adolescents in an underserved community as well as associations with community ecology (e.g. access to drugs and alcohol; community connectedness), family dynamics, and intrapersonal domains of self-efficacy and empowerment. Such research may help in supporting target treatment and prevention.

FUNDING: Substance Abuse and Mental Health Services Administration …

Department Of Family & Community Medicine Transdisciplinary Evaluation And Support Clinic (Teasc), Martin Gonzales, Toni Benton, John Phillips, Gail Thaler, Helene Silverblatt, May Goldenberg, Clark Hardgrave, Amber Seik, Pat Beery, Shelly Marek, Liz Donsbach, Rae Romero

Brain & Behavioral Health Research Day

This poster submission highlights the success and impact the Transdisplinary Evaluation and Support clinic (TEASC) has had in providing healthcare and behavioral requirements of adolescents and adults with Intellectual and Developmental Disabilities (IDD). Over the past three decades, the TEASC has successfully implemented a consultative model to address the complex needs of individuals with I/DD, catering to both teens and adults. This innovative team model offers statewide consultative services, extending support to individuals, their families, and their support teams. TEASC employs a variety of interdisciplinary clinical initiatives to provide clinical expertise throughout the state. The TEASC Evaluation involves in-person consultations …

Ascl1 Regulates Astrocyte And Oligodendrocyte Cell Fate, Proliferation, And Migration In The Dorsal Cortex, Luis E. Paez-Beltran, Bianca L. Myers, Milindu Liyanapathirana, Haojie Chen, Estrella Villicana, Tou Yia Vue

Brain & Behavioral Health Research Day

Crucial questions in developmental neuroscience are how a common progenitor gives rise to different cell types and how development changes over time. This study explores both questions by examining how ASCL1 regulates the cell fate, migration, and proliferation of glial progenitors and how they give rise to different progeny at different stages. Understanding the mechanisms of neurodevelopment not only increases our understanding of fundamental biology but allows us to comprehend pathologies that share similar mechanisms.

Russians Fleeing Putin’S Country: Trauma, Daily Stressors, Anxiety, Depression, Post Traumatic Stress Disorder, Maria Mccready, David Witherington, Steven Verney, Dmitry Boltyanskiy

Brain & Behavioral Health Research Day

The turmoil unleashed by the Russian invasion of Ukraine in February 2022 triggered a mass migration of individuals from Russia to nearby countries like Armenia and Georgia. Amidst this upheaval, concerns have arisen regarding the mental well-being of Russian emigrants and their experiences during this turbulent period. To bridge this gap in knowledge, our study aims to examine the mental health status of adult Russian emigrants who departed from their homeland after the beginning of the conflict.

Drawing from a sample of 67 participants, comprising 30 females and 3 non-binary individuals, our research focuses on communities in Armenia and Georgia, …

Pediatric Postoperative Stroke Recognition, Thomas Ferrer, Juliet Velhagen R Valhagen, Tim Peterson, Codruta Soneru

Brain & Behavioral Health Research Day

Introduction

The recognition and diagnosis of pediatric strokes (PS) or cerebrovascular accidents (CVA) is a well known challenge.¹ In postoperative environments, additional factors such as sedation, regional anesthesia, and postoperative limitations exacerbate the difficulty.² This overview of PS etiology and clinical characteristics includes postoperative guidelines and identifies current literature gaps.

Discussion

As in adults, PS can be ischemic: Arterial Ischemic Stroke (AIS) and Cerebral Sinovenous Thrombosis (CSVT); or hemorrhagic (HS): intracerebral and subarachnoid hemorrhage. The presentation of these varies substantially both from each other and their adult counterparts. Younger children and infants may have unexpected presentations such as …

Single Nucleus Transcriptomics Reveals Cell Type-Specific Heterogeneity On The Effects Of Gestational Ozone Exposure Within The Brain, Sumira Phatak, Kathryn Brayer, Russell Hunter, David Scieszka, Andrea Pasmay, Selita Lucas, Jamie Padilla, Matthew Campen, Shahani Noor

Brain & Behavioral Health Research Day

Air pollution, particularly ozone, is a major global health concern that impacts respiratory health and has been linked to pregnancy-related complications. Our study exposed mice to ozone during early pregnancy, revealing significant changes within the cells of the brain. Combined ozone exposure and pregnancy affected pathways associated with neurodegenerative diseases, potentially influencing long-term maternal and offspring health. These findings highlight the importance of addressing air pollution's impact on both respiratory and neurological health during pregnancy.

Altered Neuronal Network Connectivity In Children With Fetal Alcohol Spectrum Disorder, Maryam H. Alsameen, L Flynn, C Cerros, M Williams, D E. Hill, J M. Stephen

Brain & Behavioral Health Research Day

We investigated how Fetal Alcohol Spectrum Disorder (FASD) affects brain connections in children 6-8 years of age using noninvasive brain imaging. Comparing 52 children, half with FASD, we found differences in brain connectivity patterns. Children with FASD showed reduced connections in areas related to thinking and movement, while typically developing children had stronger connections in sensory and movement areas. These findings help us understand how FASD affects the brain's wiring and functioning.

FUNDING: NIAAA P50AA022534, R01AA029605.

Investigating Anticipation For Alcohol In Mice Elicited By Cues Predicting Its Availability, Seth David, Dominic Furlano, Monserrat Orozco, David N. Linsebardt

Brain & Behavioral Health Research Day

Non-expert summary:

Excessive alcohol consumption leads to premature deaths and high societal costs, often exacerbated by relapses triggered by alcohol-associated cues. This study employed a mouse model of binge alcohol drinking to investigate if such cues elicit anticipatory behavior. We found that over time, all mice became responsive to cues irrespective of fluid provided. Surprisingly, control males spent more time near their sipper than other groups during cues, despite only ethanol mice exhibiting craving-associated drinking patterns.

Abstract:

Background: Excessive alcohol consumption contributes to approximately 140,000 deaths and $249 billion dollars in societal costs each year. This is due in …

Dissecting The Functional Impairment Of Wild-Type P53 In Human Glioblastoma, Leopoldo A. García-Montaño, Yamhilette Licon Munoz, Frank Martinez, Kandee Gallegos, Huining Kang, Sara G.M Piccirillo

Brain & Behavioral Health Research Day

Glioblastoma is the most common malignant brain tumor in adults. In contrast to several cancers, where the tumor suppressor gene TP53 is altered, most glioblastoma patients retain a non-mutant TP53 gene. However, the survival of these patients is similar to that of mutant patients, suggesting that p53 is nonfunctional. To test this hypothesis, we analyzed data from The Cancer Genome Atlas, identified potential regulators of p53, and we will test their function in patient-derived cells.

Eeg Acquisition Methods During The First Year Of Life: Unm Pilot Of Healthy Brain And Child Development Study (Hbcd), Alexandria Wiesel, Lidia Enriquez Marquez, Lawrence Leeman, Ludmila N. Bakhireva, James F. Cavanagh

Brain & Behavioral Health Research Day

Background:

The HEALthy Brain and Child Development (HBCD) is the largest multi-site longitudinal prospective study in the US. The national cohort is composed of local pregnant persons and children who continue with HBCD for 5+ years. HBCD seeks to examine brain and child development amongst substance and environmental exposures, social, cultural, and genetic influences.

Methods:

Repeated electroencephalography (EEG) assessments are performed throughout HBCD, starting at Visit 3 (3-9 months). EEG signals and corresponding stimuli are analyzed to measure event-related potentials (ERPs). EEG acquisition includes 4 age-adjusted tasks recorded via MagstimEGI 128 channel net, EKG lead, and Net Station Acquisition. Video …

Building Community Through Learning Traditional Irish Music, Laura Olson

Music ETDs

This thesis foregrounds traditional Irish music and the role it plays in building community. I demonstrate how the genre is defined and transmitted plays an important role in how inclusive the genre can be and where changes need to be made to be more welcoming to new individuals. Playing or singing in musical groups has been shown to combat loneliness but there has been little focus on specific music genres, especially those that are instrumental in nature. This thesis shows that instrumental music can be another tool to combat loneliness and promote overall health and wellbeing using the vehicle of …

Unm Hslic Organizational Chart 2024, Sally Bowler-Hill

HSLIC Organizational Charts

No abstract provided.

Hsc Connects Newsletter - March 14, 2024, Unm Hsc Communications

HSC Connects Newsletters

Weekly newsletter of the UNM Health Sciences Center.

Neuroplasticity In The Dentate Gyrus: A Multimethod Investigation On Hippocampal Ltp Following Prenatal Alcohol Exposure, Monica Goncalves-Garcia

Psychology ETDs

Studies have demonstrated alcohol-related deficits in LTP associated with histaminergic and glutamatergic impairments. The histaminergic H3R inverse agonist ABT-239 has shown promise in reversing these deficits. The present study focuses on another H3R inverse agonist, SAR-152594, and its impact on LTP deficits following moderate PAE. The findings reveal that systemic administration of 1 mg/kg of SAR-152594 reverses deficits in potentiation fEPSPs in adult male rats exposed to moderate PAE. Time-frequency analyses of evoked responses indicate PAE-related reductions in power during the fEPSP and increased power during later components of evoked responses, both reversed by SAR-152594. These results provide further evidence …

Investigating The Structural Ensemble And Dynamic Interactions Of Protein Interacting With C-Kinase 1 (Pick1) Using Computational Tools, Amy E. Stevens

Chemistry and Chemical Biology ETDs

Protein Interacting with C Kinase-1 (PICK1) is a scaffolding protein that offers a promising solution to support individuals suffering from substance use disorders. While many efforts have been put towards identifying small-molecule drugs with the potential to target PICK1 and ultimately support individuals suffering from the effects of substance use disorders, all efforts have so far fallen short. The purpose of this work is to use computational tools to assist the design of a small-molecule inhibitor of PICK1 while also advancing the knowledge of its biological functions. This work provides information that is currently missing the field by (1) revealing …

03/11/2024 Meeting, Varina A. Kosovich

Meeting Minutes

No abstract provided.

Hsc Connects Newsletter - March 8, 2024, Unm Hsc Communications

HSC Connects Newsletters

Weekly newsletter of the UNM Health Sciences Center.

03-07-24 Hsc Committee Agenda, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

03.07.24 HSC Committee Agenda

03-07-2024 Hsc Committee Minutes, Helen Maestas

HSC Committee (A subcommittee of the UNM Board of Regents)

03-07-2024 HSC Committee Minutes

To Infinity & Beyond: From Citation Analysis To Understanding Open Access Publishing, Robyn Gleasner, Robinson Lewis Worley

Posters and Presentations

The University of New Mexico Health Sciences Library and Informatics Center conducted a citation analysis to determine where faculty are publishing and open access publishing trends. The actions based on the results of this analysis including gaps in the collection, acquisitions decisions, and emerging publishing trends will be shared.

Enhancing Medical Image Quality Using Neutrosophic Fuzzy Domain And Multi-Level Enhancement Transforms: A Comparative Study For Leukemia Detection And Classification, A. A. Salama, Mahmoud Y. Shams, Huda E. Khalid, Doaa E. Mousa

Neutrosophic Sets and Systems

Medical image processing has become a critical research area due to the vast amounts of digital image data available. However, medical images often suffer from poor illumination and low visibility of significant structures, requiring image enhancement to improve image quality before processing. In this paper, we propose a technique for enhancing medical images by removing noise and improving contrast based on three different enhancing transforms. The proposed technique embeds the image into a neutrosophic fuzzy domain, where it is mapped into three different levels of trueness, falseness, and indeterminacy, and each level is processed individually using the enhancement transforms. We …

Applications Of Sets And Functions By Using An Open Sets In Fuzzy Neutrosophic Topological Spaces, Basker P, Broumi Said, Vennila J

Neutrosophic Sets and Systems

The definitions provided by the authors of the current study are offered together with a discussion of the recent advances that they have contributed. We begin with an introduction to ���� Fr#bϱN , which includes the concepts of closed and open sets. We explore characteristics in ����-βd#bϱN and ����-℮bϱN (ϱN), and provide an idea of obtained results by adding the notion of FNbϱN OS and analyzing a few of their properties in ��������. We've researched the contrasts between the derived, exterior, and frontier notions that are provided. We also looked at the ideas of 〈��bϱN〉��-functions and Γ��-segregated functions and examined …