Digital Commons Network^™

Virus-Like Particle-Based Vaccines Induce Antibody-Mediated Neutralization Of Staphylococcus Aureus Virulence, Jason Alexander Joyner

Biomedical Sciences ETDs

Staphylococcus aureus is a pathogenic bacterium that inflicts a large amount of human suffering using an arsenal of virulence factors to cause minor to life-threatening infections. Both the accessory gene regulator (agr) operon, a virulence regulatory pathway that controls expression of over 200 virulence factors, and alpha-hemolysin (Hla), a key pore-forming toxin, play a significant role in infection severity. Given the clinical trial failures of S. aureus vaccine candidates and the prevalence of antibiotic-resistant strains, novel and effective treatment options are urgently needed. Chapter 2 describes a novel virus-like particle (VLP) -based vaccine inducing agr-I-inhibiting antibodies …

Trespassing And Transcending: Newcomer Crossing And Movement In Latina And Latin American Literature, Marina C. Todeschini

Spanish and Portuguese ETDs

In times when walls are raised and human diversity condemned, stories that present the free urban movement of marginalized characters become political. While the system excludes the brown/black newcomer bodies and restricted them to the margins, the texts analyzed here bring these bodies to the center, claiming their active role in the construction of the urban fabric. This way, Latin American and Latina authors are contesting the idea of citizenship and the right to the city of newcomer subjects by narrating the freedom of geographic and symbolic movement of often disenfranchised peoples. This dissertation analyzes the claims to urban rights …

Interaction Of Optomechanical Cavities With Acoustic Waves And Oscillators, Ke Huang

Optical Science and Engineering ETDs

Resonators and oscillators are key elements in a wide variety of natural and manmade systems. As such understanding and exploiting their dynamics both as isolated devices and members of coupled systems has been the subject of intensive investigation for more than a century. The advent of optomechanical resonators (OMRs) that support strong coupling between optical and mechanical modes resulting in self-sustained optomechanical oscillations, has created new opportunities for device development and implementation of coupled oscillatory systems. One aspect of this thesis is focused on exploring some of the unique features of OMRs and optomechanical oscillators (OMOs) that can be exploited …

Understanding Attitudes Toward Healthcare Reform: The Roles Of Self-Interest, Group Identity And Racial Resentment, Maria Beatrice Livaudais

Political Science ETDs

The Patient Protection and Affordable Care Act (ACA) cemented itself as one of the most controversial pieces of legislation of the decade. Public opinion polls find Americans are often evenly split in support of the ACA. This dissertation explores the roles of self-interest, group identity, and racial resentment on attitudes toward the ACA and healthcare reform. The dissertation centers our attention on variation by race and the impact racial tensions beyond the Black-White paradigm on these attitudes. I find group identity shapes attitudes Blacks’ and Latinos’ attitudes toward the ACA but not Whites’ and racial resentment, directed toward Blacks, Latinos …

Biogeochemical Processes Affecting Arsenic (As) Release And Bioavailability Near Abandoned Mine Wastes, Cherie L. Devore

Civil Engineering ETDs

The aim of this dissertation was to investigate the biogeochemical processes affecting the mobilization and bioavailability of arsenic (As) from mining-impacted sediments to surface water sources and plants. The Cheyenne River Watershed has been affected by mining legacy for several decades. The biogeochemical cycling of As on tribal land is not well understood, which justified the following research objectives: 1) Investigate the effect of competing anions on the release of As from sediments exposed to oxidizing conditions; 2) Evaluate chemical and microbiological processes affecting the release of soluble As, Fe, and Mn from contaminated sediments under laboratory controlled aerobic and …

Exploratory Study Of Communication As A Psychosocial Factor Influencing Safer Sex Experiences Among Individuals Who Identify As Polyamorous, Cecilia Brooke Cholka

Communication ETDs

Even with over three decades of research on and promotion of safer sex, the rates of sexually transmitted infections continue to rise in the United States (CDC, 2017). Although communication about risk and protective factors is key to the promotion of safer sex behaviors, the meaning and impact of such communication is contingent upon culturally grounded understandings of safer sex among individuals of diverse sexual subcultures. This dissertation focuses on individuals who self-identified as polyamorous, a style of non-monogamy, and their understandings and experiences with safer sex. Drawing on the application of the AIDS Risk Reduction Model and narrative inquiry …

On Love And Treason: Critical White Feminist Thought For Social Justice Praxis, Amanda Joyce Parker

Language, Literacy, and Sociocultural Studies ETDs

This dissertation is a theoretical piece that examines the positionality of white women in upholding white supremacy and a framework for critical white feminist thought that will move white women toward a self-reflexive and self-implicating praxis. A white matriarchy (Parker, 2018) is fully conceptualized as part of a powerful subsystem that operates under white supremacy. Concepts, such as a race-gender bribe and white women’s negative solidarity (Combahee River Collective, 1977), are exposed and discussed as part of the workings of white matriarchy. White emotionality (Matias, 2015), intergenerational whiteness, and antiracist parenting are also analyzed. I also suggest possibilities for resistance …

Essays On Emotional Well-Being, Health Insurance Disparities And Health Insurance Markets, Disha Shende

Economics ETDs

This dissertation has three research papers. First paper looks at the effect of social networks on emotional well-being of cancer patients by studying the response of social networks on their depression symptoms. Using the data from a primary survey conducted in Nepal, the study finds that social networks significantly reduce depression symptoms among cancer patients. The results strongly advocate for the importance of the social networks in improving their emotional well-being. Second paper examines the health coverage disparities among Hispanic and non-Hispanic young adults in five southwestern states of the United States. Using the pooled data from American Community Survey …

Can A Sex Bias Be A Good Thing: Modeling Spontaneous Clearance And Sexual Susceptibility In Hcv, Tanner K. Shea

Biology ETDs

Hepatitis C virus (HCV) is a global epidemic that has been increasing for decades, afflicting millions of people who inject drugs (PWID) and is a major cause of liver disease. With novel direct-acting antivirals, treating the virus has become possible yet elimination remains out of reach. Prior research has shown significant differences in disease progression between men and women. These differences can lead to variation in incidence or what proportion of infections progress to chronic infections. We develop a mathematical model that accounts for potential differences between the sexes to evaluate the impacts on HCV transmission. We find that susceptibility …

Chronic And Acute Respiratory Pathogens: Evolutionary And Epidemiological Characteristics Of Tuberculosis, Influenza-Like Illness, And Covid-19, Julie Allison Spencer

Biology ETDs

Tuberculosis and influenza-like illness cause major disease burden for humans. In our first study, we conducted a pangenome analysis of 67 Mycobacterium tuberculosis genomes from Peru. We supported the paradigm that M. tuberculosis is highly clonal; however, a small amount of genetic diversity originates from infrequent recombina- tion events. In our second study, we reviewed the literature for parameters of five common viruses that contribute to influenza-like illness: influenza, RSV, rhinovirus, human coronavirus, and adenovirus. We found that their epidemiological parameters vary considerably, and can have broad ranges; their basic transmission rates are the most important for model outcomes. When …

Arithmetic Differential Operators On Z_P^R, Marshall Brandenburg

Mathematics & Statistics ETDs

Given a prime, p, we prove that if a function can be represented as a restricted power series, then the function is analytic.

Methods Of Uncertainty Quantification For Physical Parameters, Kellin Rumsey

Mathematics & Statistics ETDs

Uncertainty Quantification (UQ) is an umbrella term referring to a broad class of methods which typically involve the combination of computational modeling, experimental data and expert knowledge to study a physical system. A parameter, in the usual statistical sense, is said to be physical if it has a meaningful interpretation with respect to the physical system. Physical parameters can be viewed as inherent properties of a physical process and have a corresponding true value. Statistical inference for physical parameters is a challenging problem in UQ due to the inadequacy of the computer model. In this thesis, we provide a comprehensive …

Nubians Of Plutonia: Black Women In Modern Post-Apocalyptic And Dystopian Graphic Literature, Marthia D. Fuller

American Studies ETDs

This dissertation explores the deployment of race and gender in comic books and graphic novels, paying close attention to how Black womanhood and girlhood operates in the speculative future. This project suggests that the framing of black womanhood and girlhood in post-apocalyptic/dystopian spaces provide a counter to the normative notions of both while simultaneously using normative tropes of Black womanhood and girlhood to produce new ways of understanding Black femininity in the future. Nubians of Plutonia use Black feminist cultural criticisms, Black popular culture, and visual culture to ask: does graphic literature present new, more dynamic understandings of race and …

Contesting Historical Enchantment: Militarized Settler Colonialism And Refugee Resettlement In New Mexico, Christina Juhász-Wood

American Studies ETDs

This dissertation provides an interdisciplinary critical study of refugee resettlement to Albuquerque, New Mexico. I argue that refugee resettlement to the United States cannot be understood separately from the ongoing structure of settler colonialism. I analyze Albuquerque’s post-WWII militarized settlement as a settler colonial process of extraction and suburbanization that depended on Native labor and resources to fuel the growing nuclear weapons program. Albuquerque’s Kirtland Air Force Base played a role not only in displacing and thus producing refugees during the Vietnam War but also in marking Albuquerque as a distinctly militarized geography to which they were resettled. Thousands of …

Impact Of Political Action Committee On Government Contracts, Bibek Acharya

Economics ETDs

This research aims to determine whether politically active corporations are more likely to get government contracts or likely to get more massive deals than corporations that are not politically active. The research question is, to what extent is the increase in government contracts due to the presence of corporate PACs or the amount spent by corporate PACs? In sum, we expect that the existence of PACs and the higher the corporation contributions in support of candidates for federal offices, the higher their chances of getting a contract or a more massive contract. We find that corporations that have a PAC …

Maximum Likelihood Estimation Of Species Trees And Anomaly Zone Detection Using Ranked Gene Trees, Anastasiia Kim

Mathematics & Statistics ETDs

A phylogenetic tree represents the evolutionary relationships among a set of organisms. Gene trees can be used to reconstruct phylogenetic trees. The methods in this dissertation focus on the gene tree topologies with emphasis on ranked gene tree topologies. A ranked tree depicts the order in which nodes appear in the tree together with topological relationships among gene lineages. One challenge that arises during phylogenetic inference is the existence of the anomaly zones, the regions of branch-length space in the species tree that can produce gene trees that have topologies differing from the species tree topology but are more probable …

The Experience Of Being A Parent Of A Child Who Stutters And Subsequent Involvement In Support Groups: A Narrative Study, Katlyn A. Ferguson, Richard Arenas

Speech and Hearing Sciences ETDs

INTRODUCTION: Developmental stuttering generally begins after a period of typical fluency and is highly variable in its presentation and persistence. This variability along with the lack of a definitive cause and social stigma often negatively impact both children who stutter (CWS) and their caregivers. However, research on the specific effects of stuttering on the caregiver is quite sparse compared to research into the caregiver experience in other disorders. Additionally, although social support has been identified as a primary protective factor for other caregivers, little evidence exists to show how support groups benefit caregivers of CWS.

METHOD: Five parents participated in …

Neogene Drainage Reversal And Colorado Plateau Uplift In The Salt River Area, Jordan Curtis Anderson

Earth and Planetary Sciences ETDs

The modern Salt River flows southwest from the Colorado Plateau, through the Arizona Transition Zone and into to the Basin and Range. Rivers in this area flowed northeast during the Paleogene from the Laramide Mogollon Highlands into structural basins of the topographically lower southern Colorado Plateau area. One of these rivers carved the Salt River paleocanyon through a portion of the Mogollon Highlands known as the Apache Uplift to similar depths as the modern Grand Canyon. This study refines the timing of this drainage reversal in the Salt River area by constraining the ages of paleoriver sediments deposited during the …

Bodies In Shame: Writing Trauma And Affective Unsettlement In Post-Genocide Rwanda Fiction, Cole A. Carvour

Foreign Languages & Literatures ETDs

This thesis analyzes Boubacar Boris Diop’s Murambi, le livre des ossements and Véronique Tadjo’s L’Ombre d’Imana: voyages jusqu’au bout du Rwanda. I argue that both authors write trauma by employing both a dominant realist style and the trauma aesthetic with attention to the embodied experiences of genocide victims and survivors in both styles. In doing so, each author contributes to impeding indifference surrounding the 1994 Rwandan genocide. Furthermore, I assert that one effect of writing trauma is that of affective unsettlement or affective travel, or the registering of psychic and physical shame and other related affective responses in the …

Synthesis, Self-Assembly And High-Pressure Properties Of Nanoparticles And Hybrid Nanocomposites, Lingyao Meng

Nanoscience and Microsystems ETDs

Nanoparticles have gained significant scientific interests owing to their unique structural dimensions, size- and shape-tunable properties, and numerous fascinating applications, from opto-electronics, sensor devices, to energy, environmental, and medical fields. Furthermore, the synergistic integration of other materials, including organic polymers, with nanoparticles provides new opportunities and strategies to obtain nanocomposites with superior properties and functionalities. While there is already significant research on the synthesis and characterizations of nanoparticles and hybrid nanocomposites, some research questions, such as how to design and control the interfacial morphology in polymer/nanoparticle hybrid nanocomposites, how to synthesize metal- organic framework (MOF) nanoparticles in well-defined and uniform …

The Magic Of Love: Love Magic In Medieval Romance, Dalicia Raymond

English Language and Literature ETDs

This project examines authorial representations of the morality of three functions of love magic: to induce, to disrupt, and to facilitate love in twelfth- through fifteenth-century Middle High German, Old French, and Middle English romances. Using a cultural studies approach with close textual analysis and informed by gender studies, it investigates medieval romance authors’ discomfort with love inducing magic and asserts that this discomfort is a response to the magic’s violation of free will, a central tenet of medieval theology. I find that authors condemn love inducing magic but mark specific instances acceptable through explicit clarification of divine approval. Love …

The Effect Of Semantic Neighborhood Density On Vocabulary Learning In Spanish As A Second Language And Spanish As A Heritage Language, Marián Giráldez Elizo

Language, Literacy, and Sociocultural Studies ETDs

This dissertation reviews the results from an online survey created to identify and compare how second language (L2) learners and heritage language (HL) learners of Spanish, enrolled in beginning-level coursework at the college level, acquired and built vocabulary. A total of 451 participants completed the survey. The purpose of the online survey was to serve as a baseline for pedagogical purposes, since it provided information about participants’ language profiles and the way they build vocabulary based on sematic relatedness. Overall, the findings from the survey showed that HL and L2 learners differ in the way they build semantic neighborhoods and, …

Factors Influencing The Retention Of Participants In Online Cancer Screening Training Programs In India, Kavitha Dhanasekaran, Roshani Babu, Vipin Kumar, Shalini Singh, Roopa Hariprasad

Project ECHO Bibliography

Background

Online courses have broken the boundaries in imparting knowledge. While in western countries e-learning in medical education is well accepted, it is still an upcoming field in low- and middle-income countries like India. Attrition is a major threat to online courses world-wide. The objective of this article is to share the experiences in conducting online cancer screening courses, reasons for attrition and ways to improve retention.

Methods

Online training program in preventive oncology for medical professionals is being conducted since 2017, which is 14-week long with weekly one-hour sessions and specific curriculum for healthcare professionals. Since the retention of …

Mindfulness, Flow And Self-Care For Double Bass Musicians, Samuel R. Brown

Music ETDs

In this qualitative multi-case study, three college-age music majors from the local state university were interviewed, observed, and asked to complete reflections in order to answer the following questions: How do mindfulness activities affect collegiate double bass music students’ perceptions of their own playing and practicing? My secondary questions were 1) how do mindfulness activities affect flow experiences among collegiate double bass music students, and 2) how do mindfulness activities affect students’ perception of self-care? The interviews were transcribed, coded using “concept coding” (Miler, Huberman, & Saldaña, 2020), and then grouped into categories, themes, and sub-themes. The themes were time, …

Relationship Between Orthostatic Stress Response And Acute Mountain Sickness Susceptibility At High Altitude: A Pilot Study, Bryanne Bellovary, Jack Loeppky, Andrew Wells, Zac Fennel, Jeremy Ducharme, Jonathan Houck, Trevor Mayschak, Kelsey Bourbeau, Ann Gibson, Scott Drum, Christine Mermier

Health, Exercise, and Sports Sciences ETDs

The purpose of this study was to determine whether there is a difference in hemodynamic responses to head-up tilt (HUT) in subjects who do, and do not, experience acute mountain sickness (AMS) during exposure to hypobaric hypoxia. Secondarily, we aimed to determine if those hemodynamic variables altered during HUT correlated with AMS severity. Fifteen participants completed three testing sessions: 1) VO₂max test to determine workload at 50% VO₂max for hypoxia exposure; 2) HUT test consisting of supine rest for 20 min followed by 70° upright tilting for ≤ 40 min; and 3) six hours of hypobaric …

Characterization Of Partial Charge Collection Induced By Neutron Damage In High-Purity Germanium Detectors, James W. Evans

Nuclear Engineering ETDs

This paper investigates the correlation of damage induced by neutron interactions and degradation in the spectra of HPGe detectors. As neutrons kinetically interact with germanium crystals, they create interstitial and vacancy defects within the lattice. These defects then interfere with the charge migration of electron-hole pairs and reduce resolution in the observed energy spectrum. The partial charge collection produces observable spectral changes by increasing the peak width and reducing resolution (full width half maximum). A detailed characterization using various check sources was performed before and after iterations of neutron exposure in order to observe the effects of the neutron damage. …

Assessing The Validity Of Sentiment Analysis Measures Through Polychoric Correlation, Kelli N. Kasper

Mathematics & Statistics ETDs

Sentiment analysis methods extract the attitude of a text via systematic algorithms. To evaluate the validity of common sentiment analysis methods, we use polychoric correlation to compare computer-mediated methods and human-rated analogues. Our main topics of interest are the internal consistency of the raters' scores, the level of consensus among raters, and how well raters' scores correlate with those given by sentiment analysis methods for randomly collected Twitter data.

Our analysis found that there is good validity for methods that measure negative and positive sentiments in short texts, both in terms of inter-rater consistency and when comparing raters to computer-mediated …

Addiction, Attrition, And Visualizations: An Exploration Of Online Survey Panels, Alex Adams

Political Science ETDs

Due to changes in technology and individual behavior, survey methods for obtaining nationally representative public opinion survey data have changed dramatically. Survey methodologists increasingly rely on online survey panels. The data obtained from these panels is increasingly accepted as reliable for cross-sectional research designs, in part because these online survey panel samples are demographically representative on observable variables. However, over time the experience of panelists approximates a panel survey design.

This dissertation explores two concerns related to online survey panel data, (1) panel conditioning and the advent of a professional class of survey takers I call professional respondents, and (2) …

The Impact Of Social Interactions On Resettled Refugee Health, Shahjadi Zaman

Political Science ETDs

The purpose of this thesis is to investigate the effects of social interactions and other factors on the self-reported physical and mental health of former refugees in their host country. Social relationships and interactions consist of different layers extending from individual personal relations, to social networks, to collective activities. Using data from a public opinion survey of newly resettled Bhutanese and Rohingya refugees in Michigan, I find that along with their economic situations, like employment and income, social integration is an important determinant of physical and mental health among resettled refugees. In particular, resettled refugees tend to have better health …

An Autoethnography Of A Registered Nurse Living With Chronic Undiagnosed Illness, Frances M. Ricker

Nursing ETDs

Abstract

This autoethnographic study examines a registered nurse’s experience living with chronic undiagnosed illness. The number living with undiagnosed illness is unknown and little is understood about living with chronic undiagnosed illness.

This analytic autoethnography (Anderson, 2006) used multiple data sources: my journal, medical history narrative, and artifacts including my handwork, examples of my father’s handwriting, and family photographs. Narrative analysis, thematic analysis, and visual analysis were conducted.

My experience of living with chronic undiagnosed illness was characterized by three themes that reinforced isolation: not knowing, loss, and hidden secret self. Family context evidenced diverse themes of not being believed, …