Digital Commons Network^™

Risk Of Hemolytic Uremic Syndrome Related To Treatment Of Escherichia Coli O157 Infection With Different Antimicrobial Classes, Rajal K. Mody, Robert M. Hoekstra, Magdalena Kendall Scott, John Dunn, Kirk Smith, Melissa Tobin-D'Angelo, Beletshachew Shiferaw, Katie Wymore, Paula Clogher, Amanda Palmer, Nicole Comstock, Kari Burzlaff, Sarah Lathrop, Sharon Hurd, Patricia M. Griffin

Pathology Research and Scholarship

Treatment of Shiga toxin-producing Escherichia coli O157 (O157) diarrhea with antimicrobials might alter the risk of hemolytic uremic syndrome (HUS). However, full characterization of which antimicrobials might affect risk is lacking, particularly among adults. To inform clinical management, we conducted a case-control study of residents of the FoodNet surveillance areas with O157 diarrhea during a 4-year period to assess antimicrobial class-specific associations with HUS among persons with O157 diarrhea. We collected data from medical records and patient interviews. We measured associations between treatment with agents in specific antimicrobial classes during the first week of diarrhea and development of HUS, adjusting …

A Protocol For A Comprehensive Monitoring And Evaluation Framework With A Compendium Of Tools To Assess Quality Of Project Echo (Extension For Community Healthcare Outcomes) Implementation Using Mixed Methods, Developmental Evaluation Design, Smita Ghosh, Brenna M. Roth, Irene Massawe, Emmanuel Mtete, Jacob Lusekelo, Eve Pinsker, Steven Seweryn, Patrick K. Moonan, Bruce B. Struminger

Project ECHO Bibliography

Introduction: The United States Centers for Disease Control and Prevention (CDC), through U.S. President's Emergency Plan for AIDS Relief (PEPFAR), supports a third of all people receiving HIV care globally. CDC works with local partners to improve methods to find, treat, and prevent HIV and tuberculosis. However, a shortage of trained medical professionals has impeded efforts to control the HIV epidemic in Sub-Saharan Africa and Asia. The Project Extension for Community Healthcare Outcomes (ECHO^TM) model expands capacity to manage complex diseases, share knowledge, disseminate best practices, and build communities of practice. This manuscript describes a practical protocol for …

Mitochondrial Proteins In Mediating Colon Cancer And Potential Theraputics, Kunlun Yin

Chemistry and Chemical Biology ETDs

Cancer is one of the biggest threatens to human health. Many people died because of various types of cancer. Colon cancer is one of the leading causes of new incidence and mortality in the whole world. It is important to understand the mechanism of tumorigenesis and development. Based on the mechanisms, we may develop new therapeutics to improve survival rate. In Chapter 2, we discussed the PINK1 function in suppression colon cancer. We found that PINK1 deficiency can promote colon cancer, and PINK1 overexpression suppressed tumor growth in vivo and in vitro. PINK1 can activate its substrate P53, which activates …

Long-Term Video Object Detection And Tracking In Collaborative Learning Environments, Sravani Teeparthi

Electrical and Computer Engineering ETDs

Human activity recognition in videos is a challenging problem that has drawn a lot of interest, particularly when the goal requires the analysis of a large video database. The Advancing Out-of-School Learning in Mathematics and Engineering (AOLME) project provides a collaborative learning environment for middle school students to explore mathematics, computer science, and engineering by processing digital images and videos. As part of this project, around 2200 hours of video data were collected for analysis. This data was collected to understand how children learn in situations involving mathematical and programming challenges so as to recognize best teaching practices that support …

The Interaction And Progression Of Adolescent Substance Use And Co-Occurring Mental Health Problems And Social Support: A Latent Growth Modeling Approach, Jeremiah D. Simmons

Psychology ETDs

Background: Few studies have examined a reciprocal parallel process longitudinal trajectory of adolescent substance use and mental health problems simultaneously, and none have described this parallel process for adolescents receiving outpatient substance use treatment. No studies have examined how social support may account for deviations outside the overall trajectories for substance use or mental health problems. Method: Secondary data analysis examined a longitudinal parallel process latent growth model between mental health and substance use problems among adolescents who received outpatient substance use treatment. Results: Findings suggest that mental health and substance use problems are associated both initially and longitudinally, and …

Characterization Of Foamed Warm-Mix Asphalt For Workability And Moisture Damage, Biswajit Kumar Bairgi

Civil Engineering ETDs

Warm mix asphalt (WMA) technology reduces the high mixing and compaction temperatures of conventional hot mix asphalt (HMA) by approximately 10 ^°C to 40 ^°C. In WMA technology, instead of increasing the binder-aggregate temperature, the volume of asphalt is increased by injecting water into hot asphalt at high air pressure. The amount of water injected in the binder is typically determined by a trial and error process and is termed as foaming water content (FWC). Once the FWC is in contact with the hot asphalt binder, it turns into vapor with a rapid volume expansion due …

When Engineering Solutions Cause Legal Problems: The Developing Field Of Reservoir Rights And Liabilities, Joseph A. Schremmer

Faculty Scholarship

For well over a decade, the pages of this Quarterly have undoubtedly been filled with discussions of cutting-edge drilling and completion technologies. This article discusses some of the problems that all these engineering solutions have caused for the law of oil and gas. It begins in Part II with a brief outline of how the law slowly develops through the common law process and illustrates how that process responds, also slowly, to rapid technological and social changes, like the unconventional hydrocarbon revolution. Part III then surveys how courts have begun to reform the legal rights and remedies in common reservoirs …

Uptake Of Co-Testing With Hpv And Cytology For Cervical Screening: A Population-Based Evaluation In The United States, Jack Cuzick, Ruofei Du, Rachael Adcock, Walter Kinney, Nancy Joste, Ruth M. Mcdonald, Kevin English, Salina M. Torres, Debbie Saslow, Cosette M. Wheeler

Pathology Research and Scholarship

OBJECTIVES: Human papillomavirus (HPV) testing for cervical screening has been shown to increase the yield of precancerous disease and reduce the incidence of cervical cancer more than cytology alone. Here we document the state-wide uptake of co-testing with HPV and cytology in women aged 30-64 years as recommended by national and international bodies.

METHODS: Registry-based study of all screening cytology and HPV tests in New Mexico from 2008 to 2019 among women aged 21-64 years, with a focus on cytology negative tests to distinguish co-testing from reflex HPV testing to triage equivocal or mildly abnormal cytology.

RESULTS: A total of …

Therapeutic Plasma Exchange In Myasthenia Gravis: A Systematic Literature Review And Meta-Analysis Of Comparative Evidence, Tina S. Ipe, Adeola R. Davis, Jay S. Raval

Pathology Research and Scholarship

Background: Patients with Myasthenia Gravis (MG) can be treated acutely with therapeutic plasma exchange (TPE) or intravenous immune globulin (IVIG). To date, there is no definitive understanding of which of the two treatments is more effective and safer. The purpose of this study was to systematically review the literature on the comparative efficacy and safety of TPE to other available treatments for MG. Methods: A systematic literature search for studies published between 1997 and 2017 was performed per Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines using two database sources, MEDLINE (through the PubMed database) and Cochrane Library. …

Adherence To National Guidelines On Cervical Screening: A Population-Based Evaluation From A Statewide Registry, Philip E. Castle, Walter K. Kinney, Lu Chen, Jane J. Kim, Steven Jenison, Giovanna Rossi, Huining Kang, Jack Cuzick, Cosette M. Wheeler, New Mexico Hpv Pap Registry Steering Committee

Pathology Research and Scholarship

In 2012, national recommendations for cervical-cancer screening of women aged 30-64 years were quinquennial human papillomavirus and cytology co-testing or triennial cytology. Data from a state-wide surveillance program in New Mexico demonstrated 65.2% (95% confidence interval [95%CI]= 64.6%% to 65.7%) of women screened in 2019 had negative co-test within the last 3 years. Percentages of women screened in 2013, 2016, and 2019 with a prior negative co-test more than 5 and up to 7 years ago were 2.6% (95% CI = 2.2% to 2.9%), 2.1% (95% CI = 1.9% to 2.2%), and 6.5% (95% CI = 6.2% to 6.8%), respectively …

Neutrosophic Sets And Systems, Vol. 45,2021, Florentin Smarandache, Mohamed Abdel-Basset, Said Broumi

Neutrosophic Sets and Systems

No abstract provided.

"You're Going To Have To Think A Little Bit Different" Barriers And Facilitators To Using Mhealth To Increase Physical Activity Among Older, Rural Cancer Survivors, Tamar Ginossar, Heidi Rishel Brakey, Andrew L. Sussman, Brittany Price, Miria Kano, Sally M. Davis, Cindy K. Blair

Pediatrics Research and Scholarship

Wearable activity trackers (WATs) hold great promise in increasing physical activity among older cancer survivors. However, older cancer survivors who reside in rural regions are at increased risk of being digitally marginalized. The goal of this study was to learn about WATs adoption motivation and needs of rural older cancer survivors who live in New Mexico, one of the most rural states with the lowest broadband Internet connectivity in the United States. We conducted six key informant interviews and recruited 31 older cancer survivors from rural counties statewide who participated in interviews and focus groups. Our results show great interest …

Current Advances In Transfusion Medicine 2020: A Critical Review Of Selected Topics By The Aabb Clinical Transfusion Medicine Committee, Elizabeth S. Allen, Claudia S. Cohn, Sara Bakhtary, Nancy M. Dunbar, Thomas Gniadek, Courtney K. Hopkins, Jessica Jacobson, Parvez M. Lokhandwala, Ryan A. Metcalf, Colin Murphy, Micah T. Prochaska, Jay S. Raval, Hua Shan, Emily K. Storch, Monica B. Pagano

Pathology Research and Scholarship

BACKGROUND: The AABB Clinical Transfusion Medicine Committee (CTMC) compiles an annual synopsis of the published literature covering important developments in the field of transfusion medicine (TM), which has been made available as a manuscript published in Transfusion since 2018.

METHODS: CTMC committee members reviewed original manuscripts including TM-related topics published electronically (ahead) or in print from December 2019 to December 2020. The selection of topics and manuscripts was discussed at committee meetings and chosen based on relevance and originality. Next, committee members worked in pairs to create a synopsis of each topic, which was then reviewed by two additional committee …

Rheumatic Heart Disease In The United States: Forgotten But Not Gone: Results Of A 10 Year Multicenter Review., Sarah R De Loizaga, Lindsay Arthur, Bhawna Arya, Brian Beckman, Wubishet Belay, Cole Brokamp, Nak Hyun Choi, Sean Connolly, Soham Dasgupta, Tavenner Dibert, Marylou M Dryer, Lakshmi R Gokanapudy Hahn, Elizabeth Anne Greene, Daphney Kernizan, Omar Khalid, Jennifer Klein, Ryan Kobayashi, Subhrajit Lahiri, Raymond P Lorenzoni, Andrea Otero Luna, Jennifer Marshall, Theodore Millette, Lily Moore, Babu Muhamed, Meghna Murali, Kinjal Parikh, Amy Sanyahumbi, Divya Shakti, Elizabeth Stein, Sanket Shah, Hannah Wilkins, Mcallister Windom, Scott Wirth, Meghan Zimmerman, Andrew F Beck, Nicholas Ollberding, Craig Sable, Andrea Beaton

Pediatrics Research and Scholarship

Background Recent evaluation of rheumatic heart disease (RHD) mortality demonstrates disproportionate disease burden within the United States. However, there are few contemporary data on US children living with acute rheumatic fever (ARF) and RHD. Methods and Results Twenty-two US pediatric institutions participated in a 10-year review (2008-2018) of electronic medical records and echocardiographic databases of children 4 to 17 years diagnosed with ARF/RHD to determine demographics, diagnosis, and management. Geocoding was used to determine a census tract-based socioeconomic deprivation index. Descriptive statistics of patient characteristics and regression analysis of RHD classification, disease severity, and initial antibiotic prescription according to community …

Sparse Domination Of The Martingale Transform, Michael Scott Kutzler

Mathematics & Statistics ETDs

Linear operators are of huge importance in modern harmonic analysis. Many operators can be dominated by finitely many sparse operators. The main result in this thesis is showing a toy operator, namely the Martingale Transform is dominated by a single sparse operator. Sparse operators are based on a sparse family which is simply a subset of a dyadic grid. We also show the A2 conjecture for the Martingale Transform which follows from the sparse domination of the Martingale Transform and the A2 conjecture for sparse operators.

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Neutrosophic Analytic Hierarchy Process For The Analysis Of Innovation In Latin America, Rosa Evelyn Chuga Quemac, Manases Esaud Gaspar Santos, Laura Alicia Colcha Ramos, Cinthya Paulina Cisneros Zúñiga

Neutrosophic Sets and Systems

This paper analyzes the factors that are influencing the stagnation of innovation indicators in the Latin American region. To do this, an analysis is carried out to explore the existence of different groups of countries characterized by different levels of technological capacity and innovation. The elements to be analyzed during the study are obtained through the indicators evaluated in the Global Innovation Index, its 2020 edition, and the Analytic Hierarchy Process. The results show the existence of three groups of countries characterized by a different capacity for technological innovation, both in terms of technology policy and generation of technology and …

Neutrosophic Sets And Systems, {Special Issue: Impact Of Neutrosophic Scientific Publication In Latin American Context}, Vol. 44, 2021, Florentin Smarandache, Mohamed Abdel-Basset, Maikel Leyva Vazquez, Said Broumi

Neutrosophic Sets and Systems

No abstract provided.

Experiences And Perceptions Of People Living With Narcolepsy, Teresa Sellstrom

Nursing ETDs

The purpose of this study was to investigate the experiences and perceptions of persons living with narcolepsy from their perspective. An anonymous, online survey that included both open-ended and structured questions was administered to adults with narcolepsy with or without cataplexy (N = 72; 65 F) recruited through the auspices of the Narcolepsy Network (NN). A total of 69 participants responded to at least one open-ended question about experiences of diagnosis, treatment, and living with the condition. An Interpretive Description approach was used to analyze open ended responses. The major themes included serious medical issues (e.g., misdiagnosis and difficulties with …

Management Of Early Pregnancy Loss In Rural And Urban New Mexico, Anwar Jackson

Biomedical Sciences ETDs

Early pregnancy loss (EPL) is a common pregnancy condition that can be easily and effectively managed. However, there is limited data on the availability of management options, particularly in rural areas. Issues concerning limited data on early pregnancy loss management were analyzed in three ways. A literature review was performed exploring the role midwives play in EPL care. Findings from this review were written in the form of a review article. Original research was then conducted exploring differences in EPL care provision between rural and urban New Mexico. This research consisted of a questionnaire given to clinicians practicing in rural …

Virtual Peer-To-Peer Learning To Enhance And Accelerate The Health System Response To Covid-19: The Hhs Aspr Project Echo Covid-19 Clinical Rounds Initiative., Richard C. Hunt, Bruce B. Struminger, John T. Redd, Jack Herrmann, B Tillman Jolly, Sanjeev Arora, Amy J. Armistad, Amanda M. Dezan, Celine A. Bennett, Jon R. Krohmer, Lawrence H. Brown

Project ECHO Bibliography

Tasked with identifying digital health solutions to support dynamic learning health systems and their response to COVID-19, the US Department of Health and Human Services Office of the Assistant Secretary for Preparedness and Response partnered with the University of New Mexico's Project ECHO and more than 2 dozen other organizations and agencies to create a real-time virtual peer-to-peer clinical education opportunity: the COVID-19 Clinical Rounds Initiative. Focused on 3 "pressure points" in the COVID-19 continuum of care-(1) the out-of-hospital and/or emergency medical services setting, (2) emergency departments, and (3) inpatient critical care environments-the initiative has created a massive peer-to-peer learning …

Framing The Guides Transforming Libguides Creation Through Conceptual Integration With The Acrl Framework, Brooke Duffy, Kelleen Maluski, Gina Levitan

Publications

This chapter will discuss how one small liberal arts school utilized the ACRL Framework for Information Literacy for Higher Education, a year after it was filed, to build LibGuides as they adopted the software for the first time. The goal being to create guides that would not simply be topical lists of resources but conceptual starting points for discipline-specific research that also integrated the ACRL Framework. As work on the guides continued and staffing transitions occurred the intention to utilize guides as instructional tools was solidified so that they could be used as a way to introduce threshold concepts in …

Nutrition Information Resources Used By People With Systemic Sclerosis And Perceived Advantages And Disadvantages: A Nominal Group Technique Study, Nora Østbø, Elizabeth Yakes Jimenez, Sami Harb, Angelica Bourgeault, Marie-Eve Carrier, Brett D. Thombs, Scleroderma Patient-Centered Intervention Network (Spin) Diet And Nutrition Education Patient Advisory Team

Pediatrics Research and Scholarship

OBJECTIVE: Where people with systemic sclerosis (SSc) (or scleroderma) obtain diet and nutrition information to manage their disease is not known. Objectives were to identify 1) resources used by people with SSc for nutrition and diet information and 2) perceived advantages and disadvantages of resources.

METHODS: We conducted nominal group technique (NGT) sessions in which people with SSc reported nutrition and diet information resources they have used and perceived advantages and disadvantages of accessing and using resources. Participants indicated whether they had tried each resource. They rated helpfulness and importance of possible advantages and disadvantages. Items elicited across sessions were …

Financial Hardship And Health Related Quality Of Life Among Older Latinos With Chronic Diseases, Frances R Nedjat-Haiem, Tamara Cadet, Humberto Parada, Tessa Jones, Elvira E Jimenez, Beti Thompson, Kristen J Wells, Shiraz I Mishra

Pediatrics Research and Scholarship

BACKGROUND: Financial hardship influences health-related quality of life (HRQoL) of older adults. However, little is known about the relationship between financial hardship and HRQoL among vulnerable populations.

OBJECTIVE: We examined the associations between financial hardship and HRQoL among older Latinos living with chronic disease, including cancer.

METHODS: This cross-sectional study included 68 Latinos (age range 50-87) with one or more chronic health conditions who participated in a pilot randomized clinical trial. Participants responded to 11 financial hardship questions. We used factor analysis to explore constructs of financial hardship. HRQoL was assessed using the 27-item Functional Assessment of Cancer Therapy-General (FACT-G). …

Examining Self-Care Practices From A Sytemic Perspective: Understanding The Lived Experiences Of Hispanic Female Counselors In Rural New Mexico, Melissa C. Henry

Individual, Family, and Community Education ETDs

This interpretative phenomenological analysis (IPA) explored the experiences of Hispanic female counselors in rural New Mexico conceptualization and practice of self-care and wellness. The aim of the study was to understand the systemic, environmental, and cultural factors that reinforce and prevent resilience and wellness. Data consisted of two interviews: one structured hour-long demographic interview and one semi-structured hour-long interview related to the participant’s experience of identity, professional counseling, and self-care. Participants included 9 Hispanic women practicing professional counseling and living in various rural communities in New Mexico. Six main themes identified systemic, environmental, and cultural strengths and barriers for participants …

Regulation Of H2s Production And Signaling Within Vascular Endothelium, Perenkita J. Mendiola

Biomedical Sciences ETDs

Hydrogen sulfide (H2S) is a vasodilator primarily produced by cysthathionine

gamma-lyase (CSE) within the vasculature. Previous studies suggest there are

differences in CSE expression and the contribution of H2S to vasodilation in

different sized arteries. This led us to postulate that there are also regional

differences of regulators of H2S-mediated vasodilatory pathways.

This study examined the role of endothelial cell plasma membrane (EC

PM) cholesterol in regulating H2S-induced vasodilation and the role of

intracellular calcium [Ca2+]i in regulating CSE activity in vascular EC. We

hypothesized that CSE activation in EC by receptor-dependent second

messenger signaling enhances H2S production and subsequent …

Rac1 In Ovarian Cancer Metastasis And Tumor Microenvironment Remodeling: An Experimental And Computational Analysis, Melanie Rivera

Biomedical Sciences ETDs

Ovarian cancer is the leading cause of gynecologic malignancies, and the patient survival rate has not changed significantly in 20 years. Patients are often diagnosed at an advanced stage of disease with widespread tumor cell dissemination and metastasis. Therefore, drivers of ovarian cancer metastasis need to be identified. In Chapter 2, we reveal the role of Rac1 in ovarian cancer metastasis using a combination of experimental and computational approaches. In Chapter 3, we demonstrate that changes in gene expression and cytokine levels within the immunosuppressive ovarian cancer tumor microenvironment are dependent on Rac1 expression and activity. Collectively, the …

Developing An Epitope-Based Malaria Vaccine Targeting The Circumsporozoite Protein, Lucie Jelinkova

Biomedical Sciences ETDs

Malaria is a life-threatening parasitic disease that is spread to humans by mosquitos. Developing a successful vaccine for malaria has been a remarkable challenge. Plasmodium falciparum, the causative agent of malaria, is a complex organism that transforms into unique forms and infects multiple organs within the human host throughout its life cycle. In these studies we describe a virus-like particle (VLP)-based approach to developing a vaccine for malaria that targets discrete and specific sites on invading sporozoites during the pre-erythrocytic stage of infection. VLPs are noninfectious, self-assembling particles derived from viral structural proteins, and are safe and highly immunogenic. …

Goal Orientation, Regulation Of Motivation, And Academic Achievement In Pharmacy Students, Krystal L. Ward

Individual, Family, and Community Education ETDs

This study examined goal orientation in Doctor of Pharmacy Students and its relationship with regulation of motivation and academic achievement. Research questions included: 1) Do student cohorts (first-year, second-year, and third-year students) differ in their initial goal orientation? Do students’ goal orientation vary across time (from fall to spring)? 2) How does change in goal orientation impact changes in regulation of motivation? 3) How does change in goal orientation impact changes in academic achievement? 4) Which factor, regulation of motivation or academic achievement, has the strongest relationship with goal orientation?

178 participants completed survey instruments in the fall and spring …

Weedy Relations: Narratives Of Invasion And Intimacy With Tamarisk In The Chihuahuan Desert, Shannon S. Pepper

Geography ETDs

Tamarix spp., also known as salt cedar or tamarisk, is a shrub that has garnered a notorious reputation in North America as an invasive plant, with widespread policy and research advocating for its eradication in the Southwest U.S. and Northern Mexico. This study examines both governmental conservation documents and news articles to investigate narrative trends on tamarisk in the Southwestern U.S. and Northern Mexico as a contiguous region (the Chihuahuan Desert), expanding on current research to include transborder effects on the perception and management of introduced species. This paper asks: In the last 25 years, how has the movement, …

A Tale Of Itam Tails: New Insights Into The Molecular Mechanisms That Tune Fcɛri Signaling, William K. Kanagy

Biomedical Sciences ETDs

Immunoreceptor Tyrosine-based Activating Motif (ITAM) receptors are critical in sensing extracellular antigen and initiating an immune response. The ITAM receptor FcɛRI, termed the high affinity IgE receptor, is the primary promoter of inducing the Type 1 allergic response and is primarily expressed in mast cells and basophils. In this dissertation, I worked to determine how early signaling events initiated at the FcɛRI ITAM interface tune downstream signaling outcomes. I began by determining that differential phospho-tyrosine ITAM patterns produce unique recruitment profiles of the accessory kinases proteins Syk and Lyn. I next determined the differential signaling ITAM capabilities of Lyn and …