Digital Commons Network^™

Comparison Of Virulence Gene Carriage In Staphylococcus Aureus Isolates Colonizing Human Skin And Those Associated With Soft Tissue Osteoarticular Infections, Kylie Disch, Jon Femling, Parisa Mortaji, Kurt Schwalm, Aimee Yousey, Rebekkah Varjabedian, Darrell Dinwiddie, Walter Dehority

2020 Pediatric Research Forum Session

Background:

Osteoarticular infections (OAI), most commonly caused by S. aureus, cause extreme morbidity in children and may result in permanent sequelae (e.g. limb-length discrepancies). However, S. aureus is also a common colonizing bacteria of skin and a cause of soft tissue abscesses. Virulence determinants for S. aureus are likely complex, and may include the genetic composition of the isolate, the host immune response and the transcriptomic profile of the organism. A necessary first-step in characterizing these virulence factors includes assessing virulence gene carriage between S. aureus isolates from children with OAIs and from less virulent isolates.

Methods:

S. aureus …

The Window Ductus, A Rare Finding, And The Importance Of Perinatal Echocardiography, Storm Dorrough, Gavin Mccullough, Michelle Grenier

2020 Pediatric Research Forum Session

Category: Case Report

We present a case of an unusual form of the ductus arteriosus termed “window ductus,” and highlight the importance of early recognition echocardiogram. The patient presented as a 22 week fetus due to advanced maternal age, maternal cardiomyopathy, and an abnormal 4-chamber view on the fetal anatomy ultrasound. Fetal images were consistent with polyvalvular disease with redundancy of the mitral, tricuspid and aortic valves. There was an extremely abnormal pulmonic valve that was thickened, stenotic, and regurgitant due to relative immobility of the cusps, creating a narrow, tunnel-like orifice and post-stenotic dilated main pulmonary artery. The right …

Introducing The Self-Cleaning Filtration For Water Quality Sensors (Sc-Flawless) System, Aashish Sanjay Khandelwal

Civil Engineering ETDs

Sensor-based, semi-continuous observations of water quality parameters have become critical to understanding how changes in land use, management, and rainfall-runoff processes impact water quality at diurnal to multi-decadal scales. While some commercially available water quality sensors function adequately under a range of turbidity conditions, other instruments, including those used to measure nutrient concentrations, cease to function in high turbidity waters (> 100 NTU) commonly found in large rivers, arid-land rivers, and coastal areas. This is particularly true during storm events, when increases in turbidity are often concurrent with increases in nutrient transport. Here, we present the development and validation of …

Γ9Δ2t Cell Diversity And The Receptor Interface With Tumor Cells, Anna Vyborova, Dennis X. Beringer, Domenico Fasci, Froso Karaiskaki, Eline Van Diest, Lovro Kramer, Aram De Haas, Jasper Sanders, Anke Janssen, Trudy Straetemans, Daniel Olive, Jeanette Leusen, Lola Boutin, Steven Nedellec, Samantha L. Schwartz, Michael J. Wester, Keith A. Lidke, Emmanuel Scotet, Diane S. Lidke, Albert Jr Heck, Zsolt Sebestyen, Jürgen Kuball

Pathology Research and Scholarship

γ9δ2T cells play a major role in cancer immune surveillance, yet the clinical translation of their in vitro promise remains challenging. To address limitations of previous clinical attempts using expanded γ9δ2T cells, we explored the clonal diversity of γ9δ2T cell repertoires and characterized their target. We demonstrated that only a fraction of expanded γ9δ2T cells was active against cancer cells and that activity of the parental clone, or functional avidity of selected γ9δ2 T cell receptors (γ9δ2TCRs), was not associated with clonal frequency. Furthermore, we analyzed the target-receptor interface and provided a 2-receptor, 3-ligand model. We found that activation was …

How Do I Manage Long-Term Blood Component Shortages In A Hospital Transfusion Service, Claudia S. Cohn, Monica B. Pagano, Elizabeth S. Allen, Kathrine P. Frey, Thomas Gniadek, Parvez M. Lokhandwala, Colin H. Murphy, Jay S. Raval, Nancy M. Dunbar

Pathology Research and Scholarship

INTRODUCTION Temporary blood component shortages are common in some areas of the United States (US) and can usually be managed with short-term solutions.1However, a widespread, long-term shortage that leaves the blood industry with insufficient blood components to serve urgent medical needs requires additional mitigation strategies. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that caused the Coronavirus Disease 2019 (COVID-19) pandemic represents the greatest threat to the blood supply in recent memory. If the COVID-19 pandemic continues unchecked, the downward trend in blood collections will likely con-tinue.2Hospital transfusion services may be faced with unprecedented long-term shortages in blood products. A …

Coalition For Prisoners' Rights Newsletter, Vol 45-B, No. 9, Coalition For Prisoners' Rights

Coalition for Prisoners' Rights Newsletters

Worse, But Nothing Brand New

Send Us: Holiday/Calendar Card Designs

Billionaires

Virus Relief Checks

COVID in California: Los Latinos

Widespread Agreement Known

Self-Regulation And Emotional Reactivity In Infants With Prenatal Exposure To Opioids And Alcohol, Kathryn G Beauchamp, Jean Lowe, Ronald M Schrader, Shikhar Shrestha, Crystal Aragón, Natalia Moss, Julia M Stephen, Ludmila N Bakhireva

Pediatrics Research and Scholarship

BACKGROUND: Infants with prenatal substance exposure are at increased risk for developmental problems, with self-regulatory challenges being some of the most pronounced. The current study aimed to investigate the extent to which prenatal substance exposure (alcohol, opioids) impacts infant self-regulation during a relational stressor and the association between self-regulation and infant affect.

METHODS: Participants were 100 mother-child dyads recruited prenatally (Mean = 23.8 gestational weeks) and completed the Still Face Paradigm (SFP) when infants were 5 to 8 months of age (Mean = 6.9 months) as part of an ENRICH prospective birth cohort study. Based on prospective repeated assessment of …

Covid-19: Postmortem Diagnostic And Biosafety Considerations, J Matthew Lacy, Erin G. Brooks, Joshua Akers, Danielle Armstrong, Lauren Decker, Adam Gonzalez, William Humphrey, Romana Mayer, Matthew Miller, Catherine Perez, Jose Antonio Ruiz Arango, Lakshmanan Sathyavagiswaran, Wendy Stroh, Suzanne Utley

Pathology Research and Scholarship

As a result of the 2019 novel human coronavirus (COVID-19) global spread, medical examiner/coroner offices will inevitably encounter increased numbers of COVID-19-infected decedents at autopsy. While in some cases a history of fever and/or respiratory distress (eg, cough or shortness of breath) may suggest the diagnosis, epidemiologic studies indicate that the majority of individuals infected with COVID-19 develop mild to no symptoms. Those dying with-but not of-COVID-19 may still be infectious, however. While multiple guidelines have been issued regarding autopsy protocol in cases of suspected COVID-19 deaths, there is some variability in the recommendations. Additionally, limited recommendations to date have …

Postmortem Computed Tomography In Firearm Homicides: A Retrospective Case Series, Marloes E M Vester, Kurt B Nolte, Gary M. Hatch, Chandra Y. Gerrard, Reinoud D. Stoel, Rick R. Van Rijn

Pathology Research and Scholarship

Postmortem computed tomography (PMCT) is integrated into the evaluation of decedents in several American medical examiner offices and medicolegal death investigative centers in many other countries. We retrospectively investigated the value of PMCT in a series of firearm homicide cases from a statewide centralized medical examiner's office that occurred during 2016. Autopsies were performed or supervised by board-certified forensic pathologists who reviewed the PMCT scans prior to autopsy. PMCT scans were re-evaluated by a forensic radiologist blinded to the autopsy findings and scored by body region (head-neck, thoracoabdominal, and extremities). Injury discrepancies were scored using a modified Goldman classification and …

Cadmium Exposure Activates Akt/Erk Signaling And Pro-Inflammatory Cox-2 Expression In Human Gallbladder Epithelial Cells Via A Ros Dependent Mechanism, Priyanka Sharma, Trevar S. Caldwell, Megan N. Rivera, Rama R. Gullapalli

Pathology Research and Scholarship

Gallbladder cancer (GBC) is the commonest biliary tract cancer with an ill-defined etiology. We examined the role of Cd+2 exposures in a primary human gallbladder (GB) cell line model in this study. Cd+2 exposures induced decreased cell viability, reactive oxygen species (ROS) generation, altered Akt/ERK signaling pathway activation, PGE2 and COX-2 expression in a human primary gallbladder epithelial cell model. Pharmacological inhibitors were used to determine the key drivers of elevated COX-2 expression due to Cd+2 exposure. Our results show Cd+2 causes a dose- dependent reduction in GB cell viability (EC50 value – 18.6 μM). Dose-dependent activation of phospho-Akt and …

Wagon Tracks Volume 34, Issue 4 (August 2020), Santa Fe Trail Association

Wagon Tracks

2 On the Cover: The Plainsman

4 Insights from your President

5 Joanne’s Jottings

Trail News

6-7 Rendezvous 2020, 2021 Symposium

8 Education, Jr. Wagon Master

9 In Memoriam: Ron Fox, Tony Juarez

10 Point of Rocks Closed to Public

11 SFTA/DAR Task Force Intro

12 New Mexico and the Cholera Epidemic of 1831-1833

14 Career and Legacy of Manuel Armijo

21 Speakers Bureau

22 Montgomery Bell: Businessman of NM

26 Hell on Wheels: Ellsworth, Kansas

29 Membership Form

29 Chapter Reports

32 Town of Westport

Standardizing Assessment And Management Of Ankyloglossia, Marcia Nicole Cowen

Doctor of Nursing Practice Scholarly Projects

Ankyloglossia, which is characterized by a short, tight or thick lingual frenulum, can negatively impact breastfeeding. It has been recognized as a problem for centuries. Frenotomies have traditionally been performed to remove the lingual frenulum when indicated. The use of frenotomies and a focus on ankyloglossia fell out of favor in the twentieth century with renewed attention in the past several decades. Limited high-quality studies have been undertaken on ankyloglossia. There remains no standardized diagnosis or management recommendations. In efforts to promote a standardized approach that is based on current knowledge, this study will involve an educational in-service on ankyloglossia, …

Two Steps Forward, One Step Back: Where Do We Go From Here?, Steve Carr

Black History at UNM

Dr. Assata Zerai, Vice President, UNM Division for Equity and Inclusion, identifies three areas of focus to improve equity and inclusion at UNM: diversifying faculty hiring and creating an inclusive culture that supports faculty of color, creating a culturally responsive educational environment for learners, and addressing racism in health and healthcare. This article contextualizes these goals with a larger discussion about anti-discriminatory public policies and laws, as well as political and social movements both past and present. This article is a part of the Racism: An Educational Series, produced by the UNM Newsroom.

Dectin-1 Mediated Mechanical Force Generation In Candida Albicans Fungal Pathogen Recognition, Rohan Choraghe

Biomedical Engineering ETDs

Candida spp. pathogens continue to be a major health care burden with high mortality and exceeding a billion dollars in terms of healthcare cost. Candidainfection ranges from superficial dermatological infection to more serious blood stream infection in debilitated patients. One of the major lines of innate immune defense against Candidais phagocytosis. Dectin-1 is the antifungal receptor in myeloid cells responsible for most immune responses against fungi including phagocytosis. We looked into the signaling pathway coordinating this mechanical process downstream of Dectin-1. We found that Dectin-1 activation gives rise to a significant mechanical force generation mediated through RHOA-ROCK-MyosinII pathway. …

Racism In Healthcare, Elizabeth Dwyer

Black History at UNM

Living with the daily experience of racism can have direct, adverse effects on the health and wellbeing of Black, Indigenous, and People of Color (BIPOC) communities. Dr. Tracie Collins, former Dean, UNM College of Population Health, and current Secretary of Health of New Mexico, and Dr. Felisha Rohan-Minjares, Professor, UNM’s Department of Family and Community Medicine, explain how bias and racism impact health, treatment, and outcomes.

Sharpening The Cat's Paw: Reconceptualizing Cat's Paw Liability To Fit The Needs Of Contingent Workers After Armstrong V. Arcanum Grp. Inc., Ransom Smith

New Mexico Law Review

Contingent workers—those employed by staffing firms and contracting firms but often subject to the supervision and control of a firm’s client—are a particularly vulnerable class of employees, less likely to be treated by their employers with the same degree of protection against workplace discrimination as workers in traditional employment arrangements. The Tenth circuit case of Armstrong v. Arcanum Grp. Inc. magnified yet another disadvantage that contingent workers run up against when attempting to challenge an alleged discriminatory decision. Following Armstrong, contingent workers who premise their retaliatory or discriminatory discharge claims on the acts of biased employees who influence employment …

Privacy As A Civil Right, Alvaro M. Bedoya

New Mexico Law Review

As the first U.S.-born Hispanic senator, Senator Dennis Chávez of New Mexico left a rich legacy of advocacy for civil rights and civil liberties. In this lecture, the fourth U.S. Senator Dennis Chávez Endowed Lecture on Law and Civil Rights, I explore an idea at the intersection of those two bodies of law: the right to privacy. In 2020, the hallmark of surveillance is its ubiquity; “everyone is watched.” Unfortunately, this discourse erases the fact that, across American history, the burdens of government surveillance have fallen overwhelmingly on the shoulders of immigrants, heretics, people of color, the poor, and anyone …

Who Watches The Watchmen? Character And Fitness Panels And The Onerous Demands Imposed On Bar Applicants, Artem M. Joukov, Samantha M. Caspar

New Mexico Law Review

This Article discusses the onerous requirements that state bars sometimes impose on bar applicants to prove good moral character despite the vague definition of the term and the apparently limitless amount of evidence that a character and fitness panel can rely on to deny or delay admission. We present recent examples of decisions that beg the question of whether state bars are really preventing the entry of the unethical into the profession or simply screening out applicants that panelists dislike. We also discuss at least one potential problem highlighted within the process by COVID-19. This Article argues that while most …

Genetic Evidence, Maoa, And State V. Yepez, Nita A. Farahany, Roderick T. Kennedy, Brandon L. Garrett

New Mexico Law Review

This amicus brief offers two main contributions. First, we describe how MAOA studies based on the prior “candidate-gene approach” are unreliable due to inherent flaws in the methodology, leading to inconsistencies in replication. Second, the general scientific consensus has emerged that the earlier MAOA studies (upon which the defense experts relied) are now an outdated method of studying psychiatric genetics. Third, to the extent that recent studies adopting the more rigorous genomewide association studies (GWAS) have attempted to replicate the earlier findings of MAOA candidate-gene studies, they have found no reliable correlation between MAOA and violence.

Early Working Memory Is A Significant Predictor Of Verbal And Processing Skills At 6-7 Years In Children Born Extremely Preterm, Jean Lowe, Carla M Bann, Janell Fuller, Betty R Vohr, Susan R Hintz, Abhik Das, Rosemary D Higgins, Kristi L Watterberg, Support Study Group Of The Eunice Kennedy Shriver National Institute Of Child Health And Human Development Neonatal Research Network

Pediatrics Research and Scholarship

OBJECTIVE: The study was designed to investigate whether attainment of object permanence, a measure of early working memory used at 18-22 months corrected age, was associated with executive function at 6-7 years in a cohort of children born extremely preterm.

STUDY DESIGN: Children enrolled in the Neuroimaging and Neurodevelopmental Outcome (NEURO) study, a secondary study to the Surfactant Positive Airway Pressure and Pulse Oximetry Trial (SUPPORT) of the NICHD NRN, were eligible for this longitudinal study. Testing completed at 18 to 22 months corrected age was compared to testing at school age with a specific focus on measures of executive …

The Rare Bone Disease Teleecho Program: Leveraging Telehealth To Improve Rare Bone Disease Care., Laura L. Tosi, Elmer N. Rajah, Michael H. Stewart, Austin P. Gillies, Tracy S. Hart, E Michael Lewiecki

Project ECHO Bibliography

PURPOSE OF REVIEW: Rare bone diseases constitute ~ 5% of all known rare diseases and can require complex, multidisciplinary care. Advancing access to current medical knowledge is an important strategy for improving care for rare bone diseases throughout the world. To support this goal, the Rare Bone Disease Alliance launched the Rare Bone Disease TeleECHO in 2019.

RECENT FINDINGS: The Rare Bone Disease TeleECHO is a monthly video teleconference that fosters a collegial community of practice and opportunities for active learning through interactive case-based learning. TeleECHO relies on a hub-and-spoke model, where medical professionals at the "hub" provide support and …

Intelligent Algorithm For Trapezoidal Interval Valued Neutrosophic Network Analysis, Florentin Smarandache, Said Broumi, Deivanayagampillai Nagarajan, Malayalan Lathamaheswari, Mohamed Talea, Assia Bakali

Branch Mathematics and Statistics Faculty and Staff Publications

The shortest path problem has been one of the most fundamental practical problems in network analysis. One of the good algorithms is Bellman-Ford, which has been applied in network, for the last some years. Due to complexity in the decision-making process, the decision makers face complications to express their view and judgment with an exact number for single valued membership degrees under neutrosophic environment. Though the interval number is a special situation of the neutrosophic, it did not solve the shortest path problems in an absolute manner. Hence, in this work, the authors have introduced the score function and accuracy …

Coalition For Prisoners' Rights Newsletter, Vol 45-B, No. 8, Coalition For Prisoners' Rights

Coalition for Prisoners' Rights Newsletters

The Redemption Campaign - Embracing Clemency

Las Muertes por Coronavirus en EE.UU.

Innocents in Prison

"Close Down San Quentin"

Other Blatant Violations

Sexual Dysfunction After Rectal Cancer Treatment, Sarah M. Popek

Clinical and Translational Science Center Scholarly Output

Introduction: Treatment for rectal cancer results in sexual dysfunction. Sexual function is a component of the HR-QOL (health related quality of life) measures. The incidence of sexual dysfunction following treatment for rectal cancer and its impact on the HR-QOL is not well delineated, particularly on women.

Objectives: To prospectively assess the degree of sexual dysfunction that occurs after treatment for Stage I-III rectal cancer and the corresponding short term (<3 months) and long term (<2 years) effect on the Quality of Life measure for oncology (QOL-30).

Methods: Validated questionnaires will be administered to assess sexual function and quality of life. The International Index of Erectile Dysfunction will be administered to male patients and …

Quaternary Shelf-Slope Development In The Northern Gulf Of Alaska From Combined Geophysical And Geomorphologic Analysis, Wesley A. Clary

Earth and Planetary Sciences ETDs

This dissertation follows the hybrid format as defined by the Office of Graduate Studies at the University of New Mexico. The three chapters defined herein were prepared as manuscripts to be submitted for publication in peer reviewed journals in the field of Earth sciences. A version of chapter 1 was published in Proceedings of the Integrated Ocean Drilling Program, 2017, Volume 41. Chapter 2 was submitted to Marine Geology in Feb 2020, and is under revision as of this date. A version of chapter 3 will be submitted to the Journal of Geophysical Research. In chapter 1, I …

Lattice Of Maximal-Primary Ideals In Quadratic Orders, Ryan Bridges

Mathematics & Statistics ETDs

An order is a subring of the ring of integers of an algebraic extension, Peruginelli and Zanardo classified the lattices of orders with prime index inside te ring of integers of quadratic extensions of the rational numbers. The lattices are quite striking and have different layered structure depending on whether the prime is inert, split, or ramified. This thesis considers the orders which have prime power index inside the Gaussian integers. This is a nice generalization of the work of Peruginelli and Zanardo, and succeeds in a few classifications of specific instances of orders derived from inert primes.

Bayesian Analysis Of Single Molecule Fluorescence Microscopy Data, Mohamadreza Fazel

Physics & Astronomy ETDs

The diffraction limit can be circumvent by creating and exploiting independent behaviors of the sample at lengths scale below the diffraction limit. In fluorescence microscopy, the independence arises from individual fluorescent labels switching between dark and fluorescence states. The fluorophores can then be localized employing the generated sparse image frames. Finally, the resulting list of coordinates is utilized to generate high resolution images or to gain quantitative insight into the underlying biological structures. Therefore image processing and post-processing are essential stages of SMLM techniques.

In this dissertation, Reversible Jump Markov Chain Monte Carlo was employed to implement Bayesian analysis of …

Secondary Electron Yield Measurements On Materials Of Interest To Vacuum Electron Communication Devices, Talal Ahmed Malik

Electrical and Computer Engineering ETDs

Microwave vacuum electron devices are a critical part of communication satellite payloads. The phenomenon of multipactor breakdown (MPB) can cause the performance of these devices to deteriorate, including their partial or total destruction. MPB depends on a number of factors, including the secondary electron yield (SEY) of materials used within the device. The process of electron multiplication, which leads to breakdown, initiates with the impact of primary electrons on target surfaces, and the resonance of free electrons within an oscillating electromagnetic field under vacuum conditions. Therefore, it is of interest to find materials and surface treatment methods that exhibit low …

Speech Characteristics Of Professional Fighters, Sofiya Krasilshchikova, Amy Neel Ph.D., Jessica Dawn Richardson Ph.D., Rick Arenas Ph.D., Lauren Bennett Ph.D., Sarah Banks Ph.D., Charles Bernick Ph.D.

Speech and Hearing Sciences ETDs

The aims of this project were to accurately measure and describe speech characteristics of professional fighters; and to analyze the future potential of using speech characteristics as biomarkers for acquired neurogenic decline or chronic traumatic encephalopathy (CTE). The Professional Fighters Brain Health Study (PFBHS) is a longitudinal project investigating the effect of repeated head trauma in professional combatants. The PFBHS provided recorded speech samples for this project. This study measured accurate speech characteristics of 102 professional boxers and mixed martial artists and compared these results to a group of 27 age-matched healthy controls. Analysis revealed a significant difference in articulation …

"A Comparison Of Variable Selection Methods Using Bootstrap Samples From Environmental Metal Mixture Data", Paul-Yvann Djamen

Mathematics & Statistics ETDs

In this thesis, I studied a newly developed variable selection method SODA, and three customarily used variable selection methods: LASSO, Elastic net, and Random forest for environmental mixture data. The motivating datasets have neuro-developmental status as responses and metal measurements and demographic variables as covariates. The challenges for variable selections include (1) many measured metal concentrations are highly correlated, (2) there are many possible ways of modeling interactions among the metals, (3) the relationships between the outcomes and explanatory variables are possibly nonlinear, (4) the signal to noise ratio in the real data may be low. To compare these methods …