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Full-Text Articles in Entire DC Network
Spatio-Temporal Dynamics Of Fungal Communities And Their Effects On Plants, Kel Cook
Spatio-Temporal Dynamics Of Fungal Communities And Their Effects On Plants, Kel Cook
Biology ETDs
Fungi perform several critical functions in the environment. Spatiotemporal distributions of fungal communities will mediate when and where these functions happen and how they vary across the landscape. I first explored tropical tree canopy fungal community variation at small spatial scales and documented near total turnover of fungi across sub-meter distances and among adjacent substrates. The second chapter analyzed fungal turnover over the course of three years, where community stability was driven primarily by abundant fungi. In the third chapter, I tested effects of the environment, including host plant and habitat, on canopy fungal communities and found only small effects, …
From Wave Propagation To Spin Dynamics: Mathematical And Computational Aspects, Oleksii Beznosov
From Wave Propagation To Spin Dynamics: Mathematical And Computational Aspects, Oleksii Beznosov
Mathematics & Statistics ETDs
In this work we concentrate on two separate topics which pose certain numerical challenges. The first topic is the spin dynamics of electrons in high-energy circular accelerators. We introduce a stochastic differential equation framework to study spin depolarization and spin equilibrium. This framework allows the mathematical study of known equations and new equations modelling the spin distribution of an electron bunch. A spin distribution is governed by a so-called Bloch equation, which is a linear Fokker-Planck type PDE, in general posed in six dimensions. We propose three approaches to approximate solutions, using analytical and modern numerical techniques. We also present …
The Effectiveness Of Mind Maps As A Study Tool In An Undergraduate Human Nutrition Class To Increase Knowledge, Exam Scores, And Final Grades, Suzanne Porter-Bolton
The Effectiveness Of Mind Maps As A Study Tool In An Undergraduate Human Nutrition Class To Increase Knowledge, Exam Scores, And Final Grades, Suzanne Porter-Bolton
Individual, Family, and Community Education ETDs
The objective of this quasi-experimental study was to assess whether instructor-prepared mind maps increased knowledge, exam scores and final grades in undergraduate students enrolled in an introductory human nutrition course. Two sections of the same class (one intervention, one control) were taught by the same student instructor/investigator. Mind maps were posted online for the intervention class following each chapter lecture. Students tracked their study methods, including whether they used the mind maps. Exam scores and final grades were analyzed and compared for differences in learning and course performance between groups. There were no statistically significant differences in exam scores or …
Mucosal Immune System Of African Lungfish, Ryan D. Heimroth
Mucosal Immune System Of African Lungfish, Ryan D. Heimroth
Biology ETDs
Conquering land was an apex moment in the evolution of vertebrates. Physiologically, the first vertebrates to transition to life on land had to adapt in order to survive in an oxygen-rich environment where gravitational forces and limited water prevailed. Several extant vertebrates including anurans and lungfish, survive droughts by undergoing aestivation. Unfavorable environmental conditions trigger lungfish to aestivate. Aestivation is a process of metabolic torpor wherein the fish will encase itself in a mucus cocoon and not move until favorable environmental conditions (food and water) are reintroduced. Aestivation can be reproduced in laboratory settings and, thus, lungfish can be used …
A Multicultural Study Of The Experience Of Grief Following Involuntary Job Loss, Diane Lacen
A Multicultural Study Of The Experience Of Grief Following Involuntary Job Loss, Diane Lacen
Individual, Family, and Community Education ETDs
A MULTICULTURAL STUDY OF THE EXPERIENCE OF GRIEF FOLLOWING INVOLUNTARY JOB LOSS
by DIANE BYRD LACEN
B. A., English, The University of New Mexico, 1989 M. A., Secondary Education, The University of New Mexico, 1996 M. A., Counseling and Guidance, New Mexico Highlands University, 2005 Ph.D., Counselor Education, The University of New Mexico, 2020
ABSTRACT
Unemployment affects many individuals and families in today’s world. This qualitative multiple-case study design examined how individuals from diverse backgrounds experienced grief following involuntary job loss. A purposeful sampling consisted of nine adults who represented the multicultural diversity in New Mexico. Triangulation of methods included …
Is It Time To Revisit Qualified Immunity?, Joseph A. Schremmer, Sean M. Mcgivern
Is It Time To Revisit Qualified Immunity?, Joseph A. Schremmer, Sean M. Mcgivern
Faculty Scholarship
The right to sue and defend in the courts of the several states are essential privileges of citizenship. Eight generations ago, this right was unavailable to black people, because descendants of African slaves were never intended to be citizens. Then, and for years to come, local governments failed to protect African Americans from violence and discrimination and were sometimes complicit in those violations.
Qualified immunity was born in 1982 when the Supreme Court decided Harlow v. Fitzgerald. With an outflow of questionable court decisions shielding officers solely because they act under color of state law, it is time for the …
Predictors Of Birth Center Sustainability In The United States, Melanie Cabezas Phipps
Predictors Of Birth Center Sustainability In The United States, Melanie Cabezas Phipps
Nursing ETDs
Pregnant women from all racial and socioeconomic communities deserve safe, personalized, and affordable ways to give birth. To meet all three needs, focus is increasing on birth centers, a midwifery model that provides family-centered care before, during, and after normal pregnancy, labor, and birth. However, many U.S. birth centers face significant obstacles to financial sustainability, particularly in rural areas. A better understanding of the factors that contribute to a birth center’s operational success is needed for practitioners and groups interested in establishing or maintaining a birth center, as well as to inform policymakers seeking to improve health care equity, outcomes, …
Disciplinary Frontier(S) Between The “Americas”, Helen B. K. Marodin
Disciplinary Frontier(S) Between The “Americas”, Helen B. K. Marodin
Hemisphere: Visual Cultures of the Americas
No abstract provided.
(Review) Indelible Ink: Native Women, Printmaking, Collaboration, Presented At The University Of New Mexico Art Museum, David Saiz, Paloma Barraza
(Review) Indelible Ink: Native Women, Printmaking, Collaboration, Presented At The University Of New Mexico Art Museum, David Saiz, Paloma Barraza
Hemisphere: Visual Cultures of the Americas
No abstract provided.
Severing Union: The Queer Performance Of Steven Paul Judd’S “Stop The Dapl”, Matthew Irwin
Severing Union: The Queer Performance Of Steven Paul Judd’S “Stop The Dapl”, Matthew Irwin
Hemisphere: Visual Cultures of the Americas
No abstract provided.
Factors Related To Retention And Self-Efficacy Of Special Education Teachers Working With Students With Autism Spectrum Disorder In Tabuk-Saudi Arabia: Teachers’ Interviews, Abdullah M. Alatawi
Factors Related To Retention And Self-Efficacy Of Special Education Teachers Working With Students With Autism Spectrum Disorder In Tabuk-Saudi Arabia: Teachers’ Interviews, Abdullah M. Alatawi
Special Education ETDs
Special educators' self-efficacy and retention may be negatively impacted due to many factors related to work conditions and internal factors related to teachers themselves. In this qualitative methodology, I aimed to explore factors that influence teachers of students with autism spectrum disorder (ASD) to stay in their careers and factors affecting their self-efficacy to teach students with autism in Tabuk-Saudi Arabia. This study was based upon Bandura's theoretical construct of self-efficacy and conceptual models of special educators' retention. Six participants: four male and two female special educators participated in semi-structured interviews. After using the qualitative data analysis program Dedoose to …
Expert Opinion On Verification Of Antimicrobial Susceptibility Tests, Jean B. Patel, Richard B. Thomson, Kevin Alby, Esther Babady, Karissa Culbreath, Marcelo F. Galas, Shawn R. Lockhart, Brian V. Lubbers, Margie Morgan, Sandra S. Richter, Susan Sharp, Ribhi M. Shawar, Ana Maria Cardenas, German Esparza, Nicole Hubbard, Mark G. Papich, Audrey N. Schuetz
Expert Opinion On Verification Of Antimicrobial Susceptibility Tests, Jean B. Patel, Richard B. Thomson, Kevin Alby, Esther Babady, Karissa Culbreath, Marcelo F. Galas, Shawn R. Lockhart, Brian V. Lubbers, Margie Morgan, Sandra S. Richter, Susan Sharp, Ribhi M. Shawar, Ana Maria Cardenas, German Esparza, Nicole Hubbard, Mark G. Papich, Audrey N. Schuetz
Pathology Research and Scholarship
On behalf of the Clinical and Laboratory Standards Institute (CLSI), the Expert Panel on Microbiology would like to respond to the recent commentary by Kirby and colleagues voicing concerns related to the verification of commercial antimicrobial susceptibility testing (AST) for new drugs that are introduced into the clinical laboratory (1). The CLSI Expert Panel on Microbiology oversees the direction and general guidance of the CLSI microbiology subcommittees, including the Subcommittee on Antimicrobial Susceptibility Testing, the Subcommittee on Antifungal Susceptibility Testing, and the Subcommittee on Veterinary Antimicrobial Susceptibility Testing. The authors of the recent commentary propose that verification studies are not …
Predictors Of Recovery In Advocacy-Based Refugee Treatment Outcome: The Role Of Prior Traumatic Experiences And Current Chronic Stressors, Meredith A. Blackwell
Predictors Of Recovery In Advocacy-Based Refugee Treatment Outcome: The Role Of Prior Traumatic Experiences And Current Chronic Stressors, Meredith A. Blackwell
Psychology ETDs
Refugees are at an increased vulnerability to mental health disorders compared to citizens of wealthier nations. The present study looks at the symptom trajectories of 290 refugees in a psychosocial community-based participatory intervention. A three-level generalized linear mixed model examined the predictive impact of exposure to trauma and chronic stress at baseline on posttraumatic stress and mood symptoms over time. Results showed that only higher chronic stress at baseline was associated with a steeper decrease in both PTSD and mood scores, but these effects differed by nationality. However, with chronic stress entered as a time-varying covariate instead only African participants …
Effects Of Closed Loop Transcranial Alternating Current Stimulation Targeting Slow Oscillation Sleep On Post-Sleep Object Location Learning, Bradley M. Robert
Effects Of Closed Loop Transcranial Alternating Current Stimulation Targeting Slow Oscillation Sleep On Post-Sleep Object Location Learning, Bradley M. Robert
Psychology ETDs
Modulating sleep architecture to augment memory performance can provide valuable insight into how sleep contributes to memory. Slow wave activity has been identified as an important contributor to sleeps impact on memory. While the beneficial role of SWS in offline consolidation is well established research investigating SWS’s role in post-sleep memory formation is limited. Here we investigated the relationship between SWS and post-sleep learning by modulating slow wave oscillations (SWO) with closed loop transcranial alternating current stimulation (tACS) with an aim toward enhancing learning capacity for object location associations. Thirty-six subjects were randomly assigned to either sham (21) or verum …
Ms4 Swmpp 2020, National Technology & Engineering Solutions Of Sandia, Llc (Ntess) And Department Of Energy (Doe)
Ms4 Swmpp 2020, National Technology & Engineering Solutions Of Sandia, Llc (Ntess) And Department Of Energy (Doe)
Municipal Separate Storm Sewer System (MS4) Permit
Stormwater discharges from industrial activities at Sandia National Laboratories/New Mexico (SNL/NM) are eligible for coverage under the National Pollutant Discharge Elimination System (NPDES) Multi-Sector General Permit (MSGP). This Stormwater Pollution Prevention Plan (SWPPP) was prepared by National Technology and Engineering Solutions of Sandia (NTESS) for the Department of Energy (DOE) National Nuclear Security Administration (NNSA) Sandia Field Office (SFO), owner of SNL/NM, located in Albuquerque, NM. This SWPPP was prepared in compliance with the 2015 MSGP (effective June 4, 2015) and includes a description, potential pollutant sources, and control measures for each permitted site; and stormwater monitoring and compliance plans.
Argument Analysis: On First Day Of New Term, Supreme Court Seems Skeptical Of Texas’ Arguments In Interstate Water Dispute With New Mexico, Reed D. Benson
Argument Analysis: On First Day Of New Term, Supreme Court Seems Skeptical Of Texas’ Arguments In Interstate Water Dispute With New Mexico, Reed D. Benson
Faculty Scholarship
Find out more information regarding Texas v. New Mexico at SCOTUSblog.
Read more about Professor Reed Benson's involvement on the UNM Law News Page.
Comparing Deep Learning And Immunohistochemistry In Determining The Site Of Origin For Well-Differentiated Neuroendocrine Tumors, Jordan Redemann, Fred A. Schultz, Cathy Martinez, Michael Harrell, Douglas P. Clark, David R. Martin, Joshua A. Hanson
Comparing Deep Learning And Immunohistochemistry In Determining The Site Of Origin For Well-Differentiated Neuroendocrine Tumors, Jordan Redemann, Fred A. Schultz, Cathy Martinez, Michael Harrell, Douglas P. Clark, David R. Martin, Joshua A. Hanson
Pathology Research and Scholarship
Background: Determining the site of origin for metastatic well-differentiated neuroendocrine tumors (WDNETs) is challenging, and immunohistochemical (IHC) profiles do not always lead to a definitive diagnosis. We sought to determine if a deep-learning convolutional neural network (CNN) could improve upon established IHC profiles in predicting the site of origin in a cohort of WDNETs from the common primary sites.
Materials and methods: Hematoxylin and eosin (H&E)-stained tissue microarrays (TMAs) were created using 215 WDNETs arising from the known primary sites. A CNN trained and tested on 60% (n = 130) and 40% (n = 85) of these cases, …
The Relationships Between Benthic Macroinvertebrate And Local Water Quality And Physical Habitat Characteristics In The Rio Chama, New Mexico, Monika Hobbs
Water Resources Professional Project Reports
Incorporating the process of adaptive management in rivers management can assist with mitigating impacts of altered streamflow and prevent loss of aquatic biodiversity. Streamflow regimes are important drivers of stream ecology and structuring adaptive management around benthic macroinvertebrates could be an efficient means to understand ecological responses to management of streamflow regime. Over the past decade, there has been interest in implementing adaptive management practices to managing stream flow in the Rio Chama below El Vado Dam in northern New Mexico. The goal of this research project is to improve understanding of environmental drivers shape the benthic macroinvertebrate communities in …
Giant Gastric Ulcers: An Unusual Culprit, Aamer Abbass, Sameen Khalid, Vaishnavi Boppana, Joshua Hanson, Henry Lin, Denis Mccarthy
Giant Gastric Ulcers: An Unusual Culprit, Aamer Abbass, Sameen Khalid, Vaishnavi Boppana, Joshua Hanson, Henry Lin, Denis Mccarthy
Pathology Research and Scholarship
Mycophenolate Mofetil (MMF) is routinely used immunosuppressant in solid organ transplantation is commonly associated with several gastrointestinal (GI) side effects. Here we present a case of giant gastric ulcer of 5 cm from MMF use post cardiac transplant. CASE DESCRIPTION: A 56-year-old male with history of severe ischemic cardiomyopathy post heart transplant was on immunosuppression with MMF, tacrolimus and prednisone for 5 months. He presented with severe epigastric pain and intermittent episodes of melena for 1 month. His pain radiated to back that is worsened with eating. Associated with loss of appetite, vomiting and 16-pound weight loss in 3 months. …
New Mexico Health Care Workforce Committee 2020 Annual Report, University Of New Mexico - Health Sciences Center
New Mexico Health Care Workforce Committee 2020 Annual Report, University Of New Mexico - Health Sciences Center
New Mexico Health Care Workforce Committee (2013-ongoing)
Each year the New Mexico Health Care Workforce Committee studies the supply and distribution of health care providers in order to provide a report to the Legislature by October 1. The committee also makes recommendations for improving recruitment and retention of providers in New Mexico's rural and underserved areas.
Digital Whole Slide Imaging Compared With Light Microscopy For Primary Diagnosis In Surgical Pathology, Alexander D. Borowsky, Eric F. Glassy, William Dean Wallace, Nathash S. Kallichanda, Cynthia A. Behling, Dylan V. Miller, Hemlata N. Oswal, Richard M. Feddersen, Omid R M. Bakhtar, Arturo E. Mendoza, Daniel P. Molden, Helene L. Saffer, Christopher R. Wixom, James E. Albro, Melissa H. Cessna, Brian J. Hall, Isaac E. Lloyd, John W. Bishop, Morgan A. Darrow, Dorina Gui, Kuang-Yu Jen, Julie Ann S. Walby, Stephen M. Bauer, Daniel A. Cortez, Pranav Gandhi, Melissa M. Rodgers, Rafael A. Rodriguez, David R. Martin, Thomas G. Mcconnell, Samuel J. Reynolds, James H. Spigel, Shelly A. Stepenaskie, Elena Viktorova, Robert Magari, Keith A. Wharton, Jinsong Qiu, Thomas W. Bauer
Digital Whole Slide Imaging Compared With Light Microscopy For Primary Diagnosis In Surgical Pathology, Alexander D. Borowsky, Eric F. Glassy, William Dean Wallace, Nathash S. Kallichanda, Cynthia A. Behling, Dylan V. Miller, Hemlata N. Oswal, Richard M. Feddersen, Omid R M. Bakhtar, Arturo E. Mendoza, Daniel P. Molden, Helene L. Saffer, Christopher R. Wixom, James E. Albro, Melissa H. Cessna, Brian J. Hall, Isaac E. Lloyd, John W. Bishop, Morgan A. Darrow, Dorina Gui, Kuang-Yu Jen, Julie Ann S. Walby, Stephen M. Bauer, Daniel A. Cortez, Pranav Gandhi, Melissa M. Rodgers, Rafael A. Rodriguez, David R. Martin, Thomas G. Mcconnell, Samuel J. Reynolds, James H. Spigel, Shelly A. Stepenaskie, Elena Viktorova, Robert Magari, Keith A. Wharton, Jinsong Qiu, Thomas W. Bauer
Pathology Research and Scholarship
CONTEXT.—: The adoption of digital capture of pathology slides as whole slide images (WSI) for educational and research applications has proven utility.
OBJECTIVE.—: To compare pathologists' primary diagnoses derived from WSI versus the standard microscope. Because WSIs differ in format and method of observation compared with the current standard glass slide microscopy, this study is critical to potential clinical adoption of digital pathology.
DESIGN.—: The study enrolled a total of 2045 cases enriched for more difficult diagnostic categories and represented as 5849 slides were curated and provided for diagnosis by a team of 19 reading pathologists separately as WSI or …
A Two-Dimensional Spherical-Polar Multigroup Discrete Ordinates Code For Atmospheric Particle Transport, Daniel T. Wakeford
A Two-Dimensional Spherical-Polar Multigroup Discrete Ordinates Code For Atmospheric Particle Transport, Daniel T. Wakeford
Nuclear Engineering ETDs
A natural coordinate system for calculating neutral particle propagation in the atmosphere due to point sources is two-dimensional spherical-polar coordinates. Deterministic methods for solving the transport equation in this coordinate system require some interesting implementation details stemming from the two angular derivatives present in this form of the equation. In this dissertation, we present a bilinear discontinuous spatial discretization of the transport equation in this coordinate system. The weighted diamond difference discretization is applied to the angular derivative term in two angular dimensions, using zero-weighted starting directions to start the differencing. To our knowledge, the only previous deterministic code that …
A First Principles Study Of Secondary Electron Yield Of Metals And Alloys: Cu, Ni, Zn, Cuni, And Cuzn, Raul Enrique Gutierrez
A First Principles Study Of Secondary Electron Yield Of Metals And Alloys: Cu, Ni, Zn, Cuni, And Cuzn, Raul Enrique Gutierrez
Electrical and Computer Engineering ETDs
This thesis discusses the material properties of metals and alloys through a Density Functional Theory (DFT) perspective. It also establishes computational procedures necessary to predict the Secondary Electron Yield (SEY) from first principles. First, DFT calculations were carried out to calculate material properties important in the secondary electron generation and emission process, such as work function, Fermi energy, density of states, and more importantly, frequency- and momentum-dependent energy loss functions. These material properties are then used in Monte Carlo simulations to produce the energy-dependent SEY for CuNi and CuZn alloys, as well for the component metals Cu, Ni, and Zn. …
Disc Open House, September 30, 2020, Sarah R. Kostelecky, Margie Montanez, Amy E. Winter Mpa
Disc Open House, September 30, 2020, Sarah R. Kostelecky, Margie Montanez, Amy E. Winter Mpa
University Libraries & Learning Sciences Faculty and Staff Publications
Sarah Kostelecky, Director of DISC, discusses DISC's mission, vision, and examples of digital projects.
Margie Montañez, Curator, Latin American Collections, discusses noncustodial archives and decolonizing metadata in the context of digital projects.
Please see these two brief tutorials on using UNM's Digital Repository, as an approximation of Amy Winter's part of the presentation.
Introduction Totally And Partial Connectivity Indices In Neutrosophic Graphs With Application In Behavioral Sciences, Masoud Ghods, Zahra Rostami
Introduction Totally And Partial Connectivity Indices In Neutrosophic Graphs With Application In Behavioral Sciences, Masoud Ghods, Zahra Rostami
Neutrosophic Sets and Systems
No abstract provided.
A Mixed Methods Evaluation Of The Feasibility, Acceptability, And Impact Of A Pilot Project Echo For Community Health Workers (Chws), April Joy Damian, Sarafina Robinson, Faaiza Manzoor, Mandy Lamb, Adriana Rojas, Ariel Porto, Daren Anderson
A Mixed Methods Evaluation Of The Feasibility, Acceptability, And Impact Of A Pilot Project Echo For Community Health Workers (Chws), April Joy Damian, Sarafina Robinson, Faaiza Manzoor, Mandy Lamb, Adriana Rojas, Ariel Porto, Daren Anderson
Project ECHO Bibliography
Background
Despite the positive effects of community health workers (CHWs) on addressing social determinants of health, improving patient health outcomes, and decreasing overall healthcare costs, there is a lack of standardization in training and certifying this workforce, resulting in different approaches to integrating this role into medical home models. The purpose of the current study is to evaluate the application of Project ECHO (Extension for Community Healthcare Outcomes) in enhancing CHWs’ capacity to address health and social issues of vulnerable populations.
Methods
An explanatory sequential mixed methods design was applied in which all participants (N = 49) completed pre …
Comparison Of Virulence Gene Carriage In Staphylococcus Aureus Isolates Colonizing Human Skin And Those Associated With Soft Tissue Osteoarticular Infections, Kylie Disch, Jon Femling, Parisa Mortaji, Kurt Schwalm, Aimee Yousey, Rebekkah Varjabedian, Darrell Dinwiddie, Walter Dehority
Comparison Of Virulence Gene Carriage In Staphylococcus Aureus Isolates Colonizing Human Skin And Those Associated With Soft Tissue Osteoarticular Infections, Kylie Disch, Jon Femling, Parisa Mortaji, Kurt Schwalm, Aimee Yousey, Rebekkah Varjabedian, Darrell Dinwiddie, Walter Dehority
2020 Pediatric Research Forum Session
Background:
Osteoarticular infections (OAI), most commonly caused by S. aureus, cause extreme morbidity in children and may result in permanent sequelae (e.g. limb-length discrepancies). However, S. aureus is also a common colonizing bacteria of skin and a cause of soft tissue abscesses. Virulence determinants for S. aureus are likely complex, and may include the genetic composition of the isolate, the host immune response and the transcriptomic profile of the organism. A necessary first-step in characterizing these virulence factors includes assessing virulence gene carriage between S. aureus isolates from children with OAIs and from less virulent isolates.
Methods:
S. aureus …
The Window Ductus, A Rare Finding, And The Importance Of Perinatal Echocardiography, Storm Dorrough, Gavin Mccullough, Michelle Grenier
The Window Ductus, A Rare Finding, And The Importance Of Perinatal Echocardiography, Storm Dorrough, Gavin Mccullough, Michelle Grenier
2020 Pediatric Research Forum Session
Category: Case Report
We present a case of an unusual form of the ductus arteriosus termed “window ductus,” and highlight the importance of early recognition echocardiogram. The patient presented as a 22 week fetus due to advanced maternal age, maternal cardiomyopathy, and an abnormal 4-chamber view on the fetal anatomy ultrasound. Fetal images were consistent with polyvalvular disease with redundancy of the mitral, tricuspid and aortic valves. There was an extremely abnormal pulmonic valve that was thickened, stenotic, and regurgitant due to relative immobility of the cusps, creating a narrow, tunnel-like orifice and post-stenotic dilated main pulmonary artery. The right …
Introducing The Self-Cleaning Filtration For Water Quality Sensors (Sc-Flawless) System, Aashish Sanjay Khandelwal
Introducing The Self-Cleaning Filtration For Water Quality Sensors (Sc-Flawless) System, Aashish Sanjay Khandelwal
Civil Engineering ETDs
Sensor-based, semi-continuous observations of water quality parameters have become critical to understanding how changes in land use, management, and rainfall-runoff processes impact water quality at diurnal to multi-decadal scales. While some commercially available water quality sensors function adequately under a range of turbidity conditions, other instruments, including those used to measure nutrient concentrations, cease to function in high turbidity waters (> 100 NTU) commonly found in large rivers, arid-land rivers, and coastal areas. This is particularly true during storm events, when increases in turbidity are often concurrent with increases in nutrient transport. Here, we present the development and validation of …
Γ9Δ2t Cell Diversity And The Receptor Interface With Tumor Cells, Anna Vyborova, Dennis X. Beringer, Domenico Fasci, Froso Karaiskaki, Eline Van Diest, Lovro Kramer, Aram De Haas, Jasper Sanders, Anke Janssen, Trudy Straetemans, Daniel Olive, Jeanette Leusen, Lola Boutin, Steven Nedellec, Samantha L. Schwartz, Michael J. Wester, Keith A. Lidke, Emmanuel Scotet, Diane S. Lidke, Albert Jr Heck, Zsolt Sebestyen, Jürgen Kuball
Γ9Δ2t Cell Diversity And The Receptor Interface With Tumor Cells, Anna Vyborova, Dennis X. Beringer, Domenico Fasci, Froso Karaiskaki, Eline Van Diest, Lovro Kramer, Aram De Haas, Jasper Sanders, Anke Janssen, Trudy Straetemans, Daniel Olive, Jeanette Leusen, Lola Boutin, Steven Nedellec, Samantha L. Schwartz, Michael J. Wester, Keith A. Lidke, Emmanuel Scotet, Diane S. Lidke, Albert Jr Heck, Zsolt Sebestyen, Jürgen Kuball
Pathology Research and Scholarship
γ9δ2T cells play a major role in cancer immune surveillance, yet the clinical translation of their in vitro promise remains challenging. To address limitations of previous clinical attempts using expanded γ9δ2T cells, we explored the clonal diversity of γ9δ2T cell repertoires and characterized their target. We demonstrated that only a fraction of expanded γ9δ2T cells was active against cancer cells and that activity of the parental clone, or functional avidity of selected γ9δ2 T cell receptors (γ9δ2TCRs), was not associated with clonal frequency. Furthermore, we analyzed the target-receptor interface and provided a 2-receptor, 3-ligand model. We found that activation was …