Digital Commons Network^™

Uba2 Variants Underlie A Recognizable Syndrome With Variable Aplasia Cutis Congenita And Ectrodactyly, Rhonda E Schnur, Sairah Yousaf, James Liu, Wendy K Chung, Lindsay Rhodes, Michael Marble, Regina M Zambrano, Nara Sobreira, Parul Jayakar, Mary Ella Pierpont, Matthew J Schultz, Pavel N Pichurin, Rory J Olson, Gail E Graham, Matthew Osmond, Gustavo A Contreras-García, Karina A Campo-Neira, Camilo A Peñaloza-Mantilla, Mark Flage, Srikar Kuppa, Karina Navarro, Maria J Guillen Sacoto, Ingrid M Wentzensen, Maria I Scarano, Jane Juusola, Carlos E Prada, Robert B Hufnagel

Pediatrics Research and Scholarship

PURPOSE: The human chromosome 19q13.11 deletion syndrome is associated with a variable phenotype that includes aplasia cutis congenita (ACC) and ectrodactyly as specific features. UBA2 (ubiquitin-like modifier-activating enzyme 2) lies adjacent to the minimal deletion overlap region. We aimed to define the UBA2-related phenotypic spectrum in humans and zebrafish due to sequence variants and to establish the mechanism of disease.

METHODS: Exome sequencing was used to detect UBA2 sequence variants in 16 subjects in 7 unrelated families. uba2 loss of function was modeled in zebrafish. Effects of human missense variants were assessed in zebrafish rescue experiments.

RESULTS: Seven human UBA2 …

Therapeutic Plasma Exchange In Myasthenia Gravis: A Systematic Literature Review And Meta-Analysis Of Comparative Evidence, Tina S. Ipe, Adeola R. Davis, Jay S. Raval

Pathology Research and Scholarship

Background: Patients with Myasthenia Gravis (MG) can be treated acutely with therapeutic plasma exchange (TPE) or intravenous immune globulin (IVIG). To date, there is no definitive understanding of which of the two treatments is more effective and safer. The purpose of this study was to systematically review the literature on the comparative efficacy and safety of TPE to other available treatments for MG. Methods: A systematic literature search for studies published between 1997 and 2017 was performed per Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines using two database sources, MEDLINE (through the PubMed database) and Cochrane Library. …

2-Additive Choquet Similarity Measures For Multi-Period Medical Diagnosis In Single-Valued Neutrosophic Set Setting, Murat Olgun, Ezgı Turkarslan, Mehmet Unver, Jun Ye

Neutrosophic Sets and Systems

No abstract provided.

A New Approach To Group Decision Making Problem In Medical Diagnosis Using Interval Neutrosophic Soft Matrix, Somen Debnath

Neutrosophic Sets and Systems

No abstract provided.

Neutrosophic Sets Integrated With Metaheuristic Algorithms: A Survey, Samia Mandour, Ibrahim El-Henawy, Kareem Ahmed

Neutrosophic Sets and Systems

No abstract provided.

Neutrosophic Sets And Systems, Vol. 45,2021, Florentin Smarandache, Mohamed Abdel-Basset, Said Broumi

Neutrosophic Sets and Systems

No abstract provided.

Wagon Tracks Volume 35, Issue 3 (May 2021)

Wagon Tracks

2 On the Cover: The Trail to Santa Fe by Ron Kil
4 Insights from your President
5 Joanne’s Jottings
2,5-6,9, 15,30 Trail News
7-9 Roots Run Deep on the Santa Fe Trail by Marcia Fox
10-14, 23-20 Diary of William Baskerville, Jr., on the Santa Fe Trail, 1854 by Joy L. Poole
16-17 2021 Symposium
31 In Memoriam: Davy Mitchell, Robbie Roberts
31 Chapter Reports 33 Membership Information
36 American Solar Car Challenge

Current Advances In Transfusion Medicine 2020: A Critical Review Of Selected Topics By The Aabb Clinical Transfusion Medicine Committee, Elizabeth S. Allen, Claudia S. Cohn, Sara Bakhtary, Nancy M. Dunbar, Thomas Gniadek, Courtney K. Hopkins, Jessica Jacobson, Parvez M. Lokhandwala, Ryan A. Metcalf, Colin Murphy, Micah T. Prochaska, Jay S. Raval, Hua Shan, Emily K. Storch, Monica B. Pagano

Pathology Research and Scholarship

BACKGROUND: The AABB Clinical Transfusion Medicine Committee (CTMC) compiles an annual synopsis of the published literature covering important developments in the field of transfusion medicine (TM), which has been made available as a manuscript published in Transfusion since 2018.

METHODS: CTMC committee members reviewed original manuscripts including TM-related topics published electronically (ahead) or in print from December 2019 to December 2020. The selection of topics and manuscripts was discussed at committee meetings and chosen based on relevance and originality. Next, committee members worked in pairs to create a synopsis of each topic, which was then reviewed by two additional committee …

Towards Creating Smart Cities In Nepal, Ambika P. Adhikari, Keshav Bhattarai

Himalayan Research Papers Archive

Many urban centers in the world are seeking to become smart cities. Nepali city leaders are also aspiring to make their cities smart. A smart city basically has clever improvements made in three sectors of its operations: technological, human, and institutional. Globally, many cities have recently made impressive enhancements in at least one or more of these areas. Nepal’s National Planning Commission (NPC) in 2016 had released a concept paper on smart cities for Nepal, defining smart cities as sustainable, information and technology-based, with high quality services and replicable (NPC 2016). As most Nepali cities still operate with limited infrastructure, …

Longitudinal Assessment Of Cytokine Expression And Plasminogen Activation In Hantavirus Cardiopulmonary Syndrome Reveals Immune Regulatory Dysfunction In End-Stage Disease, Peter Simons, Yan Guo, Virginie Bondu, Susan L. Tigert, Michelle Harkins, Samuel Goodfellow, Cana Tompkins, Devon Chabot-Richards, Xuexian O. Yang, Laura Gonzalez Bosc, Steven Bradfute, Daniel A. Lawrence, Tione Buranda

Pathology Research and Scholarship

Pathogenic New World orthohantaviruses cause hantavirus cardiopulmonary syndrome (HCPS), a severe immunopathogenic disease in humans manifested by pulmonary edema and respiratory distress, with case fatality rates approaching 40%. High levels of inflammatory mediators are present in the lungs and systemic circulation of HCPS patients. Previous studies have provided insights into the pathophysiology of HCPS. However, the longitudinal correlations of innate and adaptive immune responses and disease outcomes remain unresolved. This study analyzed serial immune responses in 13 HCPS cases due to Sin Nombre orthohantavirus (SNV), with 11 severe cases requiring extracorporeal membrane oxygenation (ECMO) treatment and two mild cases. We …

A Novel Evaluative Method Of The Subject “Education And Society” Of The Autonomous University Of The Andes, Ecuador, Based On Plithogenic Numbers, Raúl Comas Rodríguez, Sharon Dinarza Álvarez Gómez, Edgar Ramón Arredondo Domínguez, Lisenia Karina Baque Villanueva,, Karina Pérez Teruel

Neutrosophic Sets and Systems

The subject “Education and Society” is part of the syllabus of the “Basic Education” program of the Autonomous University of the Andes, Ecuador. This subject has the complexity of linking different aspects of society, some of them not free from contradictions among themselves, and imprecision and uncertainties in assessing students’ performance. For this reason, the concepts and aspects to be evaluated on this subject are represented through the use of plithogenic numbers. Plithogenic sets were defined to model concepts arising from the dynamic interaction among other simpler ones, which may have contradictions with each other and include neutralities or indeterminacies. …

Neutrosophic Statistical Analysis Of Arthrofibrosis Of The Knee Rehabilitation, Sara Guerrón Enríquez, Zuly Ribel Nazate Chugá, Ruth Isabel Tavera, María Clemencia Villareal Gel, Darvin Manuel Ramírez Guerra

Neutrosophic Sets and Systems

This research aims at deepening the validation of knee arthrofibrosis rehabilitation techniques. It begins with a bibliographic review and an initial diagnosis that justifies the need to investigate these issues, and aspects that give consistency to them. We designed both a pre-test and a post-test, where the patient is physically examined, as well as a questionnaire is applied about the degree of pain or degree of independence. In the study we proposed to the patients to answer questions about the pain degree in form of intervals rather than single values, this allows us to assess most accurately what patients feel, …

Case-Based Legal Reasoning And Inductive Reasoning: Determination Of The Input Parameters Using Neutrosophic Ahp, Edwin Bolívar Prado Calderón, Mario Aguilar Martínez, Tania Tupamara Camargo Martínez, Lola Ximena Cangas Oña

Neutrosophic Sets and Systems

An Expert System as Case-Based Reasoning with the interaction of inductive reasoning is useful in predicting and evaluating domains that are difficult to formalize as is the case of the legal one. Since in this domain, a subjective environment is presented where the parties have contradictory points of view. Despite the multiple advantages of its implementation, the design of this type of system presents certain difficulties in establishing which are the predictive attributes that allow determining the similarity between a past situation and the current one, since they are mostly based on Boolean expressions. Which is in contradiction with the …

Assessment Of The Relevance Of A Breast Cancer Rehabilitation Program Based On A Neutrosophic Linguistic Scale, Carlos Vinicio Chiluisa Guacho, Nairovys Gómez Martínez, Yaritnza Hernández Coromoto, Riber Donoso Noroña, Julio Cesar Dupotey Hernández

Neutrosophic Sets and Systems

This investigation aims to assess the degree of efficacy of a breast cancer rehabilitation program in Ecuador. To this purpose, a group of experts evaluated the efficacy of the program using the Delphi method. Once experts were rigorously selected, they used a linguistic scale for assessing the program in different aspects. Every element of the linguistic scale was associated with a neutrosophic number, and finally statistically processed. The advantage to use neutrosophy is the possibility to deal with the imprecision in the assessment and to count on a linguistic scale, which undoubtedly usually is more appropriate to express opinions than …

Incidences Of Exploratory Research In Postgraduate University Studies: A Neutrosophic Statistic Approach, Gustavo Álvarez Gómez, Miriam Janneth Pantoja Burbano, Miryan Janeth Arévalo Haro, Aurelia María Cleonares Borbor, Rodolfo González Ortega

Neutrosophic Sets and Systems

Exploratory research corresponds to the first approach of investigative work. This type of research is very useful by allowing researchers to have a first approach or a first idea about the subject to study and will be of great help to become familiar with the method, but without providing conclusive results. It is usually carried out when the problem is in a preliminary phase. It is a process of collecting basic information on a problem that is not clearly defined. It is a very flexible technique, which implies that the researcher is willing to take risks, be patient and receptive. …

Statistical Methods And Management Of Indeterminacy In Medical Sciences. Surgical Site Infection Study After Vascular Surgery Procedures, Carlos Acosta Mayorga, Piedad Elizabeth Acurio Padilla, Guillermo Bastidas Tello, Abdel Bermúdez Del Sol

Neutrosophic Sets and Systems

Surgical site infections (SSIs) are one of the main infection control problems in modern hospitals, significantly prolonging the stay at the hospital and increasing the cost of treating patients with infections. They are the leading cause of failure for both patients and staff, including the need for repeated surgeries. The objective of this study is the epidemiological and microbiological analysis, through neutrosophic statistical tools, of surgical site infections after vascular surgery in a highly specialized vascular surgery center in the city of Guayaquil, in which 327 vascular operations were performed, during the year 2019 and the follow-up of patients was …

Design Of A Model For The Evaluation Of Social Projects Using Neutrosophic Ahp And Topsis, Bayron Pinda Guanolema, Luis German Castro Morales, Dailin Peña Suárez, Mario Javier Cabezas Arellano

Neutrosophic Sets and Systems

Projects are responses to identified problems. So a thorough analysis to detect the problem is extremely important in project management. There are countless types of projects depending on their purpose, content among other issues. Among these, those related to content and social development stand out due to the current context. In the development of this research, the characteristics of a project in a general sense are detailed and it is specified in those related to social programs, taking into account the current situation in the world, mainly influenced by the economic crisis and the Covid 19 pandemic. The foundations for …

Electronic Payments In Decentralized Autonomous Municipal Governments Of Ecuador. Decision Making Through Plithogenic Logic, Llerena Ocaña Luis Antonio, Viscaino Naranjo Fausto Alberto, Culque Toapanta Walter Vinicio, Baño Naranjo Freddy Patricio

Neutrosophic Sets and Systems

With the constant technological changes and their exponential growth due to the use of numerous applications, you can see the expansion of the electronically paid quotas which added to the organizations that experience a considerably greater misrepresentation, as well as the expansion of the quotas made with the Visa that was added to this development. Extortion can be characterized as a criminal behavior executed to obtain advantages related to money without reflecting on the results of this demonstration. Therefore, the development of an age adjustment was proposed to limit the problem using individual and regulated calculations that depend on AI …

Kpi And Logistics Dashboard Design Using Neutrosophic Statistics, Jorge Fernando Goyes García, Leonardo Humberto Carrión Hurtado, Mario Andrés León Yacelga, Jenny Fernanda Enríquez Chugá

Neutrosophic Sets and Systems

KPIs in logistics are key indicators to measure the evolution of the company and execute continuous improvement actions. This series of data, ratios, and percentages constitute a solid base on which to support our decision-making to achieve logistical excellence, by identifying with greater accuracy the opportunities for improvement to know the problem areas on time and understand the low yields. To ensure that the KPIs fulfill the purpose of generating a practical tool for all logistics professionals who wish to effectively control each of the operations that are implicit in the processes, their integration with the dashboards is necessary. This …

Prioritization Of Software Requirements Using Neutrosophic Topsis, Fredy Pablo Cañizares Galarza, Nelson Patricio Becerra Arévalo, Edmundo José Jalón Arias, Jorge Lenin Acosta Espinoza

Neutrosophic Sets and Systems

Prioritizing software requirements is one of the most significant and complex tasks for software developers. It involves a multi-criteria decision process to balance the benefit of each requirement and its cost, considering different factors and dimensions, many of which are qualitative. Although numerous prioritization methods have been developed to date, the appropriate treatment in cases of the uncertainty and indeterminacy inherent in human decisions is limited. In the present work, the neutrosophic TOPSIS is proposed as a method of prioritizing requirements. This multi-criteria and multi-expert method uses linguistic terms associated with Single Value Neutrosophic Sets and allows the inclusion of …

Assessment Of The Relevance Of A Breast Cancer Rehabilitation Program Based On A Neutrosophic Linguistic Scale, Carlos Vinicio Chiluisa Guacho, Nairovys Gómez Martínez, Yaritnza Hernández Coromoto, Riber Donoso Noroña, Dennys Raúl Dupotey Hernández

Neutrosophic Sets and Systems

This investigation aims to assess the degree of efficacy of a breast cancer rehabilitation program in Ecuador. To this end, a group of experts evaluated the efficacy of the program using the Delphi method. Once experts were rigorously selected, they used a linguistic scale for assessing the program in different aspects. Every element of the linguistic scale was associated with a neutrosophic number, and finally statistically processed. The advantage to use neutrosophy is the possibility to deal with the imprecision in the assessment and to count on a linguistic scale, which undoubtedly usually is more appropriate to express opinions than …

Indeterminate Control Diagrams As Health Control Tools, Elizabeth Germania Vilema Vizuete, Alina Rosa Soria Acosta, María Verónica Aveiga Hidalgo, Clara Eliza Pozo Hernández, Maylevis Morejón Valdés

Neutrosophic Sets and Systems

In recent decades, the development of techniques that allow continuous or periodic blood pressure measurement, both systolic and diastolic, in different individuals has shown that it experiences spontaneous variations in 24 hours. The variability of blood pressure has been calculated based on the standard deviation, and it has been possible to determine that this, with significant differences between individuals, behaves in such a way that the systolic pressure is higher than the diastolic. It has also been reported that the fluctuation is more significant in hypertensive patients than in normotensive patients, as the level of indeterminacy exists. Control charts, as …

Selection Of Investment Projects In A Plithogenic Environment, Ariel Romero Fernández, Gustavo Álvarez Gómez, Sary Del Rosio Álvarez Hernández, William Roberto Álvarez Arboleda, Adonis Ricardo Rosales García

Neutrosophic Sets and Systems

Nowadays, the economic crisis affecting the countries makes more important the selection process of investment projects. Such is the case of Ecuador where the Multi-annual Public Investment Plan 2017-2021 establishes indicative amounts of public investment that are projected to be executed annually to achieve each of the nine strategic objectives of the National Development Plan that pay tribute to the Sustainable Development Goals of the UN. This plan has certain weaknesses that may not allow an effective and efficient choice at the same time. Which entails a scenario of uncertainty for the Ecuadorian investment process. So we dare to say …

Digital Transformation Of Marketing In Small And Medium Enterprises Through Social Networks: Plitogenic Decision-Making, Carlos Roberto Sampedro Guaman, Diego Paul Palma Rivera, Silvio Amable Machuca Vivar, Estalin Vladimir Arrobo Lapo

Neutrosophic Sets and Systems

How companies relate to customers and the global society has changed over time; those who do not use internet marketing and social networks have reduced their recognition. The archaic ways businesses handled their marketing have caused a considerable lag in their online sales and the many benefits they can offer. The revolution in the use of technology is currently fundamental for business; practitioners can find several areas to apply this resource, such as decision-making, teleworking, and sales, among others. This allows adapting business operations and services efficiently. Companies leverage a combination of cutting-edge technologies to modernize legacy business operations and …

Evaluation Of The Effectiveness In The National Social Rehabilitation System Using Neutrosophy And Compensatory Operators, Rosa Leonor Maldonado Manzano, Jessica Jazmín Cellán Palacios, Federico Miguel Estrella Gómez

Neutrosophic Sets and Systems

Deprivation of liberty is a mechanism used by the State to reduce unlawful conduct and preserve a peaceful coexistence among its inhabitants. Having a transparent, equitable, and egalitarian administration of justice is essential when a person violates peace and harmony. The effectiveness of this system lies in need to synergistically achieve efficiency and effectiveness in both the bureaucracy and the actions inherent to it. Failures today affect the remarkable work in the Social Rehabilitation Centers, which violates the inherent rights of adults in conflict. The situation was modeled with compensatory fuzzy logic using the single value neutrosophic numbers to deal …

Neutrosophic Statistics For Project Management. Application To A Computer System Project, Ariel Romero Fernández, Lourdes Viviana Moreira Rosales, Olga Germania Arciniegas Paspuel, Walter Bolívar Jarrín López, Anthony Rafael Sotolongo León

Neutrosophic Sets and Systems

This research aims to apply a mathematical procedure of the project evaluation and review technique (PERT) in a neutrosophic environment. For such purpose, the elements of the three PERT estimates are considered neutrosophic elements, more specifically, trapezoidal neutrosophic numbers. The technique used is novel and attractive since it allows to overcome the limitations of the different Fuzzy PERT methods and handle indeterminacy mathematically. On this occasion, the neutrosophic PERT method is applied to managing a computer system development project. The PERT method made it possible to estimate the minimum duration of the project, the beta parameters of the duration of …

Method For Recommending Custody To Minors Based On Parental Responsibility Using A Neutrosophic Cognitive Map, Denisse Elizabeth Huera Castro, Marcelo Raúl Dávila Castillo, Eugenio Javier Escobar Gonzáles, Milton Rodrigo Hidalgo Ruiz

Neutrosophic Sets and Systems

Children and adolescents under custody are a phenomenon that occurs daily in the country. Many homes are disorganized because parents abandon their children and leave them in the hands of guardians, who do not take good care of children and adolescents, usually being victims, having consequences in their behavior due to lack of the proper protection of their children parents. These children and adolescents are sometimes victims of violent situations, that is, the rights of children and adolescents are violated. It is necessary to analyze the use of neutrosophic cognitive maps on this problem to determine and characterize the variable …

Plithogenic Logic For Determination Of Strategic Solutions For Ergonomic Occupational Health Risks, Gustavo Eduardo Fernández Villacrés, Fausto Alberto Viscaino Naranjo, Roberto Rolando López Domínguez

Neutrosophic Sets and Systems

This research aims to evaluate the knowledge about the incidence of ergonomic risks in the occupational health of the teachers of the UNIANDES University. Our starting point was the problem related to many physical affectations suffered by teachers and registered in the Institution's medical department system. Then they were scientifically based on topics such as occupational health, occupational risks, ergonomics, and technological elements. Methodologically, we worked with a population of 478 teachers from which a sample of 218 people was selected. Digital survey through the Forms application and the AHP Saaty method were the investigative techniques we used. Among the …

Measuring Legal And Socioeconomic Effect Of The Declared Debtors Usign The Ahp Technique In A Neutrosophic Framework, Jesús Estupiñán Ricardo, Zoila Mireya Mariscal Rosado, Esther Karina Castro Pataron, Verónica Yesenia Valencia Vargas

Neutrosophic Sets and Systems

For the development of a business and its inherent economic requirements, the owners usually have to accept bank commitments that turn them into debtors. Many times situations may occur that make it impossible to deal with these debts, so insolvency must be declared, a process that has adverse effects on both the debtors and their families and employees. The current economically precarious situation in Ecuador has led to an increase in this kind of problem. Due to the affectation observed in the canton of Pastaza. The authors of this paper have a special interest in studying this phenomenon, which comprises …

Neutrosophic Multicriteria Methods And Pestel Analysis For The Evaluation Of Informal Trade Impact, Oscar Roberto Espinoza Lastra, Luis Eduardo Álvarez Gómez, Dina Angélica Ipiales Espín, Beatriz Elizabeth Ramírez Rodríguez

Neutrosophic Sets and Systems

In towns where social phenomena such as poverty, migration and unemployment prevail, the informal market acquires special relevance, as is the case in Ecuador. The country has currently experienced a rise in this market, for example in the province of Pastaza, City of Puyo, where the Mariscal Market is located. In this market, most people are engaged in informal trade. A situation that has a negative impact on the economy and therefore requires an analysis which, due to the nature of the phenomenon, requires the intervention of multicriteria methods for its evaluation and decision-making. That is why this research aims …