Digital Commons Network^™

Guidance On The Critical Shortage Of Sodium Citrate Coagulation Tubes For Hemostasis Testing, Robert C. Gosselin, Annette Bowyer, Emmanuel J. Favaloro, Jill M. Johnsen, Giuseppe Lippi, Richard A. Marlar, Keith Neeves, Marian A. Rollins-Raval

Pathology Research and Scholarship

Recent manufacturing problems and increased utilization has created a shortage of 3.2% sodium citrate blood collection tubes used for coagulation testing, causing stakeholders such as hospitals, clinics and laboratories, to find suitable alternatives. Considerations for in-house citrate blood collection tube preparations or purchasing commercial products from unknown manufacturing sources is of particular concern to laboratories that perform coagulation testing. It is well recognized that variability exists between citrate blood collection tube manufacturers, thereby making any transition to new blood collection methods more challenging than simply switching to a new source. This document provides provisional guidance for validating alternative sources of …

Integrin Activation Is An Essential Component Of Sars-Cov-2 Infection, Peter Simons, Derek A. Rinaldi, Virginie Bondu, Alison M. Kell, Steven Bradfute, Diane S. Lidke, Tione Buranda

Pathology Research and Scholarship

SARS-CoV-2 infection depends on binding its spike (S) protein to angiotensin-converting enzyme 2 (ACE2). The S protein expresses an RGD motif, suggesting that integrins may be co-receptors. Here, we UV-inactivated SARS-CoV-2 and fluorescently labeled the envelope membrane with octadecyl rhodamine B (R18) to explore the role of integrin activation in mediating cell entry and productive infection. We used flow cytometry and confocal microscopy to show that SARS-CoV-2^R18 particles engage basal-state integrins. Furthermore, we demonstrate that Mn2+, which induces integrin extension, enhances cell entry of SARS-CoV-2^R18. We also show that one class of integrin antagonist, which binds to …

Data Sharing Workshop, Lori D. Sloane

Posters and Presentations

Learning Objectives:

• Identify the key elements of planning clinical research data management
• Outline steps needed to develop a data collection plan
• Locate standards, validated instruments, and coding schemes for research
• Describe and implement the different components of a data management plan
• Introduction to OpenRefine data tool

Tetraspanin Cd82 Regulates S1pr, Chelsea A. Saito-Reis, Victoria D. Balise, Erica M. Pascetti, Magdalena Jiminez, Jennifer M. Gillette

Pathology Research and Scholarship

Hematopoietic stem and progenitor cell (HSPC) mobilization into the blood occurs under normal physiological conditions and is stimulated in the clinic to enable the isolation of HSPCs for transplantation therapies. In the present study, we identify the tetraspanin CD82 as a novel regulator of HSPC mobilization. Using a global CD82 knockout (CD82KO) mouse, we measure enhanced HSPC mobilization after granulocyte-colony stimulating factor (G-CSF) or AMD3100 treatment, which we find is promoted by increased surface expression of the sphingosine 1-phosphate receptor 1 (S1PR

A Multi-Criteria Fuzzy Neutrosophic Decision-Making Model For Solving The Supply Chain Network Problem, Ahteshamul Haq, Srikant Gupta, Aquil Ahmed

Neutrosophic Sets and Systems

No abstract provided.

Neutrosophic Pythagorean Sets With Dependent Neutrosophic Pythagorean Components And Its Improved Correlation Coefficients, R. Radha, A. Stanis Arul Mary, R. Prema, Said Broum

Neutrosophic Sets and Systems

No abstract provided.

Identification Of The Most Significant Risk Factor Of Covid-19 In Economy Using Cosine Similarity Measure Under Svpns-Environment, Priyanka Majumder, Suman Das, Rakhal Das, Binod Chandra Tripathy

Neutrosophic Sets and Systems

No abstract provided.

An Algorithm Based On Correlation Coefficient Under Neutrosophic Hypersoft Set Environment With Its Application For Decision-Making, Rana Muhammad Zulqarnain, Imran Siddique, Shahzad Ahmad, Sehrish Ayaz, Said Broum

Neutrosophic Sets and Systems

No abstract provided.

Pulling Back The Curtain: A Follow-Up Report From The Aba Criminal Justice Section Women In Criminal Justice Task Force, Maryam Ahranjani

Faculty Scholarship

In an era when women’s hard-fought and hard-earned participation in the workforce is in peril, the ABA Criminal Justice Section’s Women in Criminal Justice Task Force (TF) continues its groundbreaking work of documenting challenges in hiring, retention and promotion of women criminal lawyers. Pulling Back the Curtain follows up on the initial findings of the TF. The findings are published in the Berkeley Journal of Criminal Law and the ABA Criminal Justice magazine. This report describes the results of a subsequent survey of diverse criminal lawyers and judges conducted at the end of 2020. The survey posed questions related to …

Growth Rates Of Infants Randomized To Continuous Positive Airway Pressure Or Intubation After Extremely Preterm Birth, Ariel A. Salas, Waldemar A. Carlo, Barbara T. Do, Edward F. Bell, Abhik Das, Krisa P. Van Meurs, Brenda B. Poindexter, Seetha Shankaran, Noelle Younge, Kristi L. Watterberg, Rosemary D. Higgins, Eunice Kennedy Shriver National Institute Of Child Health And Human Development Neonatal Research Network

Pediatrics Research and Scholarship

OBJECTIVE: To evaluate the effects of early treatment with continuous positive airway pressure (CPAP) on nutritional intake and in-hospital growth rates of extremely preterm (EPT) infants.

STUDY DESIGN: EPT infants (24

RESULTS: Growth data were analyzed for 810 of 1316 infants enrolled in SUPPORT (414 in the intervention group, 396 in the control group). The median gestational age was 26 weeks, and the mean birth weight was 839 g. Baseline characteristics, total nutritional intake, and in-hospital comorbidities were not significantly different between the 2 groups. In a regression model, growth rates between birth and 36 weeks of PMA, as well …

Ethics Of Ai In Pathology: Current Paradigms And Emerging Issues, Chhavi Chauhan, Rama R. Gullapalli

Pathology Research and Scholarship

Deep learning has rapidly advanced artificial intelligence (AI) and algorithmic decision-making (ADM) paradigms, affecting many traditional fields of medicine, including pathology, which is a heavily data-centric specialty of medicine. The structured nature of pathology data repositories makes it highly attractive to AI researchers to train deep learning models to improve health care delivery. Additionally, there are enormous financial incentives driving adoption of AI and ADM due to promise of increased efficiency of the health care delivery process. AI, if used unethically, may exacerbate existing inequities of health care, especially if not implemented correctly. There is an urgent need to harness …

The Morphology And Evolution Of Transverse Aeolian Ridges On Mars, Timothy Paul Nagle-Mcnaughton

Earth and Planetary Sciences ETDs

Transverse aeolian ridges (TARs) are enigmatic and largely relict bedforms on the surface of Mars. TARs are sparsely distributed but common on Mars, but their history, preservation, and past role in the sediment cycle is not well understood. First described in 2003, and detailed extensively in 2008, our study of TARs has been narrowly focused in the last decade, with more and more research noting their presence, but little investigation of the features themselves. Recent work has mostly focused on identifying Terran analogues for TARs, but TARs remain largely a unique Martian feature. In this manuscript, I clarify and refine …

Servitudes Done "Proper"Ly: Propriety, Not Contract Law, Elizabeth Elia

Faculty Scholarship

The law of servitudes has changed dramatically in the last hundred years. Legal scholars have been successful in documenting these changes in case law, but less successful in articulating a unified set of principles that guide the current law of servitudes. One explanation that received significant attention is the idea that efficient recording systems in the United States have liberated property owners from the constraints of traditional property laws disfavoring servitudes and have allowed these owners the broader freedoms of contract law. However, this explanation, and the sweeping common law reforms that flow from it, have not resonated with courts. …

New Mexico Health Care Workforce Committee 2021 Annual Report, University Of New Mexico - Health Sciences Center

New Mexico Health Care Workforce Committee (2013-ongoing)

Each year the New Mexico Health Care Workforce Committee studies the supply and distribution of health care providers in order to provide a report to the Legislature by October 1. The committee also makes recommendations for improving recruitment and retention of providers in New Mexico's rural and underserved areas.

Piloting A Diversity, Equity, And Inclusion Needs Assessment To Explore Patron Perceptions At A University Health Science Library, Jane Morgan-Daniel, Lauren E. Adkins, Michele R. Tennant, Hannah F. Norton, Chloe Hough, Mary E. Edwards, Matthew Daley, Melissa L. Rethlefsen

Publications

Objective: A diversity, equity, and inclusion (DEI) needs assessment was conducted at a health sciences library. The objectives were to (1) quantitatively assess patrons’ attitudes towards the existing DEI climate in the library and (2) qualitatively identify contextual factors influencing patrons’ perceptions. The purpose was to better understand patrons’ views of the DEI climate in order to identify potential gaps, strengths, and areas of improvement within the library.

Population: The assessment was led by a DEI Team at the University of Florida’s Health Science Center Libraries (HSCL). HSCL serves the university’s six health science colleges from two sites, Gainesville and …

Coalition For Prisoners' Rights Newsletter, Vol. 46-C, No. 10, Coalition For Prisoners' Rights

Coalition for Prisoners' Rights Newsletters

No abstract provided.

'That Name Is Dead To Me': Reforming Name Change Laws To Protect Transgender And Nonbinary Youth, Sarah Steadman

Faculty Scholarship

For transgender and some nonbinary youth, living under a chosen name is a first step toward becoming their authentic selves. For these youth, a name change is powerful; it allows them to choose a name that matches their gender identity. They consider their birth name to be a distressing “dead” name - one that they cannot relate to and need to bury.

Using one’s chosen name decreases suicidality among transgender youth who face many challenges, including family rejection and other severe mental health stressors. Transgender and nonbinary youth can only require others to use their chosen names after obtaining a …

Reassessing The Ahistorical Judicial Use Of William Winthrop And Frederick Bernays Wiener, Joshua E. Kastenberg

Faculty Scholarship

Government lawyers, like the courts continue to cite to Winthrop. Most recently, in the pending appeal titled Larabee v. Harker, the government ‘s counsel quoted Winthrop for the proposition that “retired officers are a part of the army and so triable by court-martial—a fact indeed never admitting of question.” It is unlikely that the government’s counsel considered the matters presented in this brief article, or that Winthrop rested his statement on dicta rather than any constitutional statement on jurisdiction. Likewise, whatever criticism may be given to Justice Alito’s Ortiz dissent, I am not suggesting that either he, or Justice Neil …

Economics 2021 Apr Self-Study & Documents, University Of New Mexico

UNM Academic Program Review

UNM Economics APR self-study report for Fall 2021, fulfilling requirements of the Higher Learning Commission.

Communication & Journalism 2021 Apr Self-Study & Documents, University Of New Mexico

UNM Academic Program Review

UNM Department of Communication & Journalism APR self-study & review team report for Fall 2021, fulfilling requirements of the Higher Learning Commission.

The Physics Of Slot-Die And Gravure Coating Associated With Precision Thin Films And Coating Defects, Robert E. Malakhov

Nanoscience and Microsystems ETDs

Enabling future printable and flexible electronic (PFE) devices and technologies requires overcoming the technical challenge of manufacturing precision thin films and features at scale. Coating- and print-feature functionality for PFEs is imparted with dispersed active particulate inks that provide electronic properties via slot-die coating, a pre-metered film-deposition process, and gravure printing, a high-throughput, precision process. Both are poised to be ideal manufacturing technologies for PFEs but require further research to understand particulate effects in defect formation and processability. Therefore, overcoming the technical challenges of precision, throughput, and the complexities of particulate inks is the purpose of this work. For slot-die …

3d Printed Concrete & Polymer Concrete For Infrastructure Applications, Daniel Heras Murcia

Civil Engineering ETDs

Additive manufacturing technology has been established as one of the fastest-growing building technologies worldwide. Three-dimensional concrete printing (3DCP) has developed an increasing interest in the last decade due to its prospects as a transformative technology for industries such as the concrete precast. Besides the improvements in automation technologies in construction, traditional construction has faced considerable challenges: high accident rates, labor dependency, significant potential for automation, and high costs associated with the use of traditional formwork. In this context, three-dimensional concrete, also referred to as physical prototyping, is a novel construction technique in which the concrete is extruded layer-to-layer. 3DCP is …

A Compendium Of Inorganic Photochemistry: Synthetic And Spectroscopic Discoveries, Sebastian B. Vittardi

Chemistry and Chemical Biology ETDs

This dissertation reports and examines contributions made in the advancement of inorganic photochemistry. Empirically driven assessments are allotted to the interplay between ligand sets, excited states, and photochemistry observed in metal complexes. A methodical spectroscopic examination is provided for oligothiophene-sensitized lanthanides. Their excited state dynamics were elucidated by femtosecond pump-probe spectroscopy and used to develop a model explaining their wavelength-dependent dual functionality. Iron (II) cyanide and isocyanides are evaluated to identify the efficacy of strong-field ligands in promoting charge-transfer excited states. Fundamentals of ligand field theory helped conceptualize the synthetically tunable parameters and effects transposed to their absorption dynamics. Transition …

Mitochondrial Proteins In Mediating Colon Cancer And Potential Theraputics, Kunlun Yin

Chemistry and Chemical Biology ETDs

Cancer is one of the biggest threatens to human health. Many people died because of various types of cancer. Colon cancer is one of the leading causes of new incidence and mortality in the whole world. It is important to understand the mechanism of tumorigenesis and development. Based on the mechanisms, we may develop new therapeutics to improve survival rate. In Chapter 2, we discussed the PINK1 function in suppression colon cancer. We found that PINK1 deficiency can promote colon cancer, and PINK1 overexpression suppressed tumor growth in vivo and in vitro. PINK1 can activate its substrate P53, which activates …

Civil Procedure Update 2021: New Mexico Annual Judicial Conclave, Verónica C. Gonzales

Faculty Scholarship

These materials are part of a presentation on civil procedure given to magistrate, district, appellate, and tribal court judges, justices, and staff attorneys in New Mexico courts. These materials include the language of approved and proposed amendments to the state and federal rules of civil procedure as well as summaries of relevant appellate cases issued by the New Mexico Supreme Court and Court of Appeals, the Supreme Court of the United States, and the Supreme Court of the Navajo Nation between May 1, 2021 to September 1, 2021.

Molecular Classification Improves Risk Assessment In Adult Bcr-Abl1-Negative B-All, Elisabeth Paietta, Kathryn G. Roberts, Victoria Wang, Zhaohui Gu, Georgina A N Buck, Deqing Pei, Cheng Cheng, Ross L. Levine, Omar Abdel-Wahab, Zhongshan Cheng, Gang Wu, Chunxu Qu, Lei Shi, Stanley Pounds, Cheryl L. Willman, Richard Harvey, Janis Racevskis, Jan Barinka, Yanming Zhang, Gordon W. Dewald, Rhett P. Ketterling, David Alejos, Hillard M. Lazarus, Selina M. Luger, Letizia Foroni, Bela Patel, Adele K. Fielding, Ari Melnick, David I. Marks, Anthony V. Moorman, Peter H. Wiernik, Jacob M. Rowe, Martin S. Tallman, Anthony H. Goldstone, Charles G. Mullighan, Mark R. Litzow

Pathology Research and Scholarship

Genomic classification has improved risk assignment of pediatric, but not adult B-lineage acute lymphoblastic leukemia (B-ALL). The international UKALLXII/ECOG-ACRIN E2993 (#NCT00002514) trial accrued 1229 adolescent/adult patients with BCR-ABL1- B-ALL (aged 14 to 65 years). Although 93% of patients achieved remission, 41% relapsed at a median of 13 months (range, 28 days to 12 years). Five-year overall survival (OS) was 42% (95% confidence interval, 39, 44). Transcriptome sequencing, gene expression profiling, cytogenetics, and fusion polymerase chain reaction enabled genomic subtyping of 282 patient samples, of which 264 were eligible for trial, accounting for 64.5% of E2993 patients. Among patients with outcome …

Global Population Divergence Of A Cosmopolian Desert Plant, Victor Ryan Alfaro

Biology ETDs

Genetic and phenotypic variation can have different patterns within a species if it has populations with contrasting histories. Populations can have discrete differences that are shaped by different evolutionary scenarios, but within each population, range, or region, traits and association with fitness can also be affected by both edaphic and landscape variation. For my dissertation, I surveyed and experimentally analyzed variation and adaptive potential in Sahara mustard (Brassica tournefortii), a desert annual that has endemic, invasive, and agricultural populations in Africa, Asia, and the Americas. Although my multi-trait analysis generated complex results, my findings can be applied to …

Long-Term Video Object Detection And Tracking In Collaborative Learning Environments, Sravani Teeparthi

Electrical and Computer Engineering ETDs

Human activity recognition in videos is a challenging problem that has drawn a lot of interest, particularly when the goal requires the analysis of a large video database. The Advancing Out-of-School Learning in Mathematics and Engineering (AOLME) project provides a collaborative learning environment for middle school students to explore mathematics, computer science, and engineering by processing digital images and videos. As part of this project, around 2200 hours of video data were collected for analysis. This data was collected to understand how children learn in situations involving mathematical and programming challenges so as to recognize best teaching practices that support …

The Interaction And Progression Of Adolescent Substance Use And Co-Occurring Mental Health Problems And Social Support: A Latent Growth Modeling Approach, Jeremiah D. Simmons

Psychology ETDs

Background: Few studies have examined a reciprocal parallel process longitudinal trajectory of adolescent substance use and mental health problems simultaneously, and none have described this parallel process for adolescents receiving outpatient substance use treatment. No studies have examined how social support may account for deviations outside the overall trajectories for substance use or mental health problems. Method: Secondary data analysis examined a longitudinal parallel process latent growth model between mental health and substance use problems among adolescents who received outpatient substance use treatment. Results: Findings suggest that mental health and substance use problems are associated both initially and longitudinally, and …

Exercise As A Multi-Modal Disease-Modifying Medicine In Systemic Sclerosis: An Introduction By The Global Fellowship On Rehabilitation And Exercise In Systemic Sclerosis (G-Forss), Henrik Pettersson, Helene Alexanderson, Janet L. Poole, Janos Varga, Malin Regardt, Anne-Marie Russell, Yasser Salam, Kelly Jensen, Jennifer Mansour, Tracy Frech, Carol Feghali-Bostwick, Cecília Varjú, Nancy Baldwin, Matty Heenan, Kim Fligelstone, Monica Holmner, Matthew R. Lammi, Mary Beth Scholand, Lee Shapiro, Elizabeth R. Volkmann, Lesley Ann Saketkoo

Pediatrics Research and Scholarship

Systemic sclerosis (SSc) is a heterogeneous multisystem autoimmune disease whereby its main pathological drivers of disability and damage are vascular injury, inflammatory cell infiltration, and fibrosis. These mechanisms result in diffuse and diverse impairments arising from ischemic circulatory dysfunction leading to painful skin ulceration and calcinosis, neurovascular aberrations hindering gastrointestinal (GI) motility, progressive painful, incapacitating or immobilizing effects of inflammatory and fibrotic effects on the lungs, skin, articular and periarticular structures, and muscle. SSc-related impairments impede routine activities of daily living (ADLs) and disrupt three critical life areas: work, family, social/leisure, and also impact on psychological well-being. Physical activity and …