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Medical Muse Volume 7, Issue 2 - Fall/Winter 2002

Medical Muse

No abstract provided.

Medical Muse Volume 19, Issue 2 - Fall 2014

Medical Muse

No abstract provided.

Effects Of Transcranial Direct Current Stimulation On Category Learning In Older Adults, Benjamin C. Gibson

Psychology ETDs

Those over the age of 65 occupy a growing proportion of the population. With this growth, cognitive issues that accompany aging are increasingly coming to the forefront, yet despite this focus, ways to ameliorate cognitive issues in older adults are lacking. Transcranial direct current stimulation (tDCS) offers one possibility for improving cognitive function in older adults, but tDCS application is hindered by individual factors that manifest as heterogeneity in outcomes across the literature. This is especially the case in older adults, where changes in anatomy and functionality provide a potential complication for tDCS application. Presented here are three studies seeking …

The Mindful First Amendment, Gary Myers

New Mexico Law Review

The mindfulness movement has begun to play an expanding role in personal well-being and in society more generally. Although there is an active push for mindfulness in law, its primary focus is on ways in which mindfulness techniques can help lawyers in their personal and professional lives. This article explores the possible contributions of mindfulness to the widely recognized challenges facing freedom of speech and freedom of the press in an era of severe cultural and political polarization. This article focuses on the external aspects of mindfulness—the interaction with others and with society—to assess whether its techniques might assist in …

Wirelessly Powering A Sea Of Sensors For Perimeter Security Applications, Ian River Chavez

Electrical and Computer Engineering ETDs

his thesis presents an innovative application of Inductive Power Transfer (IPT) technology for perimeter security systems. The approach leverages the physical properties of IPT to detect intrusions by monitoring voltage changes in wirelessly powered sensor nodes, which can double as components of an intrusion detection system. Disturbances in node orientation, indicative of potential intrusions, alter the sensor node’s resonant frequency and create measurable voltage shifts. This study explores the concept in-depth, from the analysis of resonant inductive coupling in various resonant inductive modes, to the design of transmit loops, sensor nodes, and the techniques required to ensure optimum power transfer. …

Myeloid Fth1 Deficiency Protects Mice From Colitis And Colitis-Associated Colorectal Cancer Via Reducing Dmt1-Imported Iron And Stat3 Activation, Zhaoli Liu, Mariella Arcos, David R. Martin, Xiang Xue

Pathology Research and Scholarship

BACKGROUND: Myeloid cells are critical for iron and immune homeostasis. Ferritin heavy chain (FTH1) is essential for intracellular iron storage. Myeloid FTH1 is important in the pathogenesis of many inflammatory diseases. However, the role of myeloid FTH1 in colitis and colitis-associated cancer has not been determined.

METHODS: Myeloid FTH1 deficient and wild-type mice were treated with dextran sodium sulfate (DSS) or azoxymethane (AOM)-DSS to compare their susceptibility to acute colitis or colitis-associated cancer.

RESULTS: Myeloid FTH1-deficient mice fed with a high-iron diet were less susceptible to DSS-induced acute colitis than wild type mice. Mechanistic studies showed that myeloid FTH1 deficiency …

The Antiviral Effects Of A Mek1/2 Inhibitor Promote Tumor Regression In A Preclinical Model Of Human Papillomavirus Infection-Induced Tumorigenesis, Adrian J. Luna, Jesse M. Young, Rosa T. Sterk, Virginie Bondu, Fred A. Schultz, Donna F. Kusewitt, Huining Kang, Michelle A. Ozbun

Pathology Research and Scholarship

Human papillomaviruses (HPVs) are a significant public health concern due to their widespread transmission, morbidity, and oncogenic potential. Despite efficacious vaccines, millions of unvaccinated individuals and those with existing infections will develop HPV-related diseases for the next two decades and beyond. The continuing burden of HPV-related diseases is exacerbated by the lack of effective therapies or cures for infections, highlighting the need to identify and develop antivirals. The experimental murine papillomavirus type 1 (MmuPV1) model provides opportunities to study papillomavirus pathogenesis in cutaneous epithelium, the oral cavity, and the anogenital tract. However, to date the MmuPV1 infection model has not …

The Haunting Aesthetics Of Empire: Filipinx America, Us Empire, And Cultural Production, Alana J. Bock

American Studies ETDs

Throughout this dissertation, I argue that US imperial knowledge production affirms US exceptionalism by disavowing the imperial violence wrought on the Philippines and its people. This disavowal not only renders the Philippines and Filipinx bodies illegible, but also haunts the Filipinx American diaspora. I argue that the haunted logics of empire are a set of relations, rather than specters of specific times and places, in which knowledge and power work together to continually produce and reproduce a specific and limiting reality and sensorium through which to view the world. In my interrogation of empire’s haunted logics, I not only look …

Examining The Effects Of Iron-Oxide Nanoparticles On Primary Gingival Keratinocytes For The Prevention Of Oral Disease, Jennifer C. Carranza

Dental Hygiene ETDs

Oral plaque biofilm has been identified as the primary contributor to dental conditions such as dental caries and periodontal disease that promotes a diverse and pervasive collection of microbial species to inhabit the oral cavity. Disrupting the plaque matrix early could help combat this global disease burden. This study evaluated the effect of IONPs on primary gingival keratinocytes.

Purpose: This study aimed to examine existing research regarding nanoparticles and determine if IONPs affect the PGK cell membranes with preliminary research to find the maximum lysis possible with PGK cells.

Methods: IONP core/shell syntheses were performed. Considering keratinocyte characteristics, examining data …

An Investigation Of Freshwater Turtle Ecology Using Stable Isotopes, Jonathan Duran

Biology ETDs

In 2022 I investigated niche partitioning among native and invasive freshwater turtles across three sites in the Middle Rio Grande using bulk stable isotope analysis. I found high degrees of niche partitioning at sites in which Red-eared sliders (Trachemys scripta) have yet to establish. However, at sites in which red-eared sliders are now the most abundant species they overlapped greatly in isotopic niche with all native turtles, in particular the painted turtle (Chrysemys picta). Using these same techniques, I then examined the trophic interactions between red-eared sliders and their acanthocephalan parasites. My results suggest that acanthocephalans …

Thermoregulation In Nocturnal Volant Endotherms Occupying Hot Deserts, William A. Talbot

Biology ETDs

The study of thermoregulation is of growing concern in this era of rapid climate change. Earlier studies such as those pioneered by Scholander and Bartholomew directed focus toward the study of endotherm survival in conditions of cold weather adversity. As techniques evolved in the measurement of parameters quantifying thermoregulation, metabolism and energy allocation, the standardization procedures has increased the comparability of data from diverse taxa. We can now search historical records and current research for explanations to the changes in the distribution, migration, extirpation or survival of animal and plant populations through time. It is increasingly common to observe dramatic …

Resolving The Paradox Of Polyploidy: Underexplored Facets Of Polyploid Plants, Benjamin P. Gerstner

Biology ETDs

Polyploidy, or whole genome duplication, is a common phenomenon in plants, but the establishment and persistence of mixed-ploidy populations remains a paradox. This dissertation explores factors that contribute to the persistence and establishment of mixed-ploidy populations in nature. The first chapter investigates the role of unreduced gametes in neopolyploid establishment and finds that variability in their formation rate can have a significant impact on polyploid establishment and persistence. The second chapter searches for evidence of soil microbes exhibiting ploidy-specificity, a pre-condition for microbe-mediated niche differentiation, a possible stabilizing mechanism contributing to ploidy coexistence. Finally, the third chapter tests for microbe-mediated …

Investigation Of Orthohantavirus Genetics In Rodent Reservoirs And Clinical Samples, Samuel Melvin Goodfellow

Biomedical Sciences ETDs

Orthohantaviruses are negative-sense, single stranded RNA viruses with trisegmented genomes that can cause severe disease in humans and are carried by several host reservoirs throughout the world. In the United States, Sin Nombre orthohantavirus (SNV) is the primary cause of hantavirus cardiopulmonary syndrome (HCPS) with a fatality rate of ~36% and the highest cases occuring in the southwest region. The primary SNV host reservoir is thought to be the western deer mouse, Peromyscus maniculatus, however it has been shown that other rodents can carry different orthohantaviruses. We designed a pan-orthohantavirus detection tool to survey several small mammal populations throughout New …

Witchy Politics: Witches And Witchcraft As Political Tropes From Malleus Malleficarum (1487) To Les Sorcières De La République (2016) And The Mercies (2020), Mallaury Joëlle Marie Gauthier

Foreign Languages & Literatures ETDs

The focus of this thesis are two recent novels featuring witches: Chloé Delaume’s Les Sorcières de la République(The Witches of the Republic, 2016) and Kiran Millwood Hargrave’s The Mercies (2020). The first is a futuristic dystopia set in 2062, during the witch trial of the Sibyl of Cumae. The second is a work of historical fiction based on witch trial records and set in seventeenth-century Finnmark (Norway). Both are feminist novels, and both emphasize the political valence of the witch as a gendered figure. This figure emerged from the misogyny of early modern demonology but acquired its contemporary contours …

The Impacts Of Transfer Learning For Ungulate Recognition At Sevilleta National Wildlife Refuge, Michael Gurule

Geography ETDs

As camera traps have grown in popularity, their utilization has expanded to numerous fields, including wildlife research, conservation, and ecological studies. The information gathered using this equipment gives researchers a precise and comprehensive understanding about the activities of animals in their natural environments. For this type of data to be useful, camera trap images must be labeled so that the species in the images can be classified and counted. This has typically been done by teams of researchers and volunteers, and it can be said that the process is at best time-consuming. With recent developments in deep learning, the process …

High Altitude Exercise, Autophagy, And Angiogenesis, Quint Nikolas Berkemeier

Health, Exercise, and Sports Sciences ETDs

Environmental hypoxia, as a result of decreased barometric pressure upon ascent to high altitudes (>2500m) presents increased physiological demands compared to low altitudes. Competitive athletes, mountaineers, wildland firefighters, military personnel, miners, and outdoor enthusiasts commonly participate in, or are exposed to, forms of exercise or physical labor at moderate to high altitudes. Interestingly, however, the majority of research on intermittent hypoxic exposure is centered around hematological markers and the skeletal muscle cellular responses to exercise in hypoxic environments remain largely unknown. Two processes that are integral for maintenance of cellular health in skeletal muscle include autophagy and angiogenesis. We …

Synthetic Biology Enabled Modification Of Bone Cells And Impact On Bone Mineral Resorption, Dulce C. Hayes

Biomedical Sciences ETDs

Development of a cell culture based bone model can contribute to biomedical research by producing a reproducible model system that mimics a bone remodeling disorder and reduces the use of animals in research studies. Synthetic biology was used to engineer osteoblast cell lines to alter a key protein in the RANKL pathway in efforts to control the bone remodeling process. Osteoblast cell lines, K7M2 and MC3T3-E1 Subclone 4 were engineered to express osteoprotegerin (OPG) and inhibit OPG expression, respectively. The upregulation of OPG expression was confirmed with Real Time PCR and Quantikine® Immunoassay. To identify the functionality of the engineered …

Cholesterol Regulation Of Egfr-Dependent Vasoconstriction In Chronic Hypoxia-Induced Pulmonary Hypertension, Rosstin Ahmadian

Biomedical Sciences ETDs

Pulmonary arterial constriction and remodeling resulting from chronic hypoxia (CH) lead to increased pulmonary vascular resistance and resultant pulmonary hypertension in patients with chronic obstructive pulmonary diseases, sleep apnea, or in residents at high altitude. Recent studies from our laboratory have demonstrated that CH augments vasoconstrictor reactivity to a variety of stimuli, including pulmonary arterial smooth muscle cell (PASMC) stretch, membrane depolarization, and stimulation of G protein-coupled receptors. This effect of CH is mediated by a switch in PASMC signaling from Ca2+-dependent mechanisms towards a novel epidermal growth factor receptor (EGFR)-NADPH oxidase 2 (NOX2)-Rho kinase Ca2+ sensitization pathway that occurs …

Role Of Endophytic Fungi On Arsenic Uptake In Solution: Insights For Bioremediation, Taylor Lillian Busch

Civil Engineering ETDs

Hazardous metals mobilized from natural deposits and mining legacy are environmental and human health concerns. The waters of our partner Native American communities affected by uranium and gold mining legacy exceed the EPA MCL of 10 µg/L arsenic (As). Bioremediation is a novel technology that uses native resources to remediate metals in the soil and groundwater. Plant-fungi symbiosis for bioremediation is widely studied, but the role of endophytic fungi in metal uptake is not well understood. The objectives of this study are to 1) determine As uptake by symbiotic endophyte Cadophora sp. and little bluestem grass (Schizachyrium scoparium) …

Effects Of Acute And Chronic Gut Injury On Secretory Lineage Differentiation, Roger Atanga

Biomedical Sciences ETDs

Acute and chronic injury to the gut has several detrimental consequences. However, dysregulation of secretory lineage cells is a common observation. To model acute gut injury, we use non-fissile uranium bearing dust (UBD), an environmental toxicant prevalent in communities adjacent abandoned uranium mines, majority of which are located in the Southwestern United States. Repeated exposure to environmental toxins and heavy metals has been obscurely linked to intestinal inflammation, increased susceptibility to pathogen-induced diseases, and higher incidences of colorectal cancer. However, there is no molecular evidence that non-fissile uranium can cause damage to the intestinal epithelia. Human colonoids exposed to UBD …

Heterochiral Dna Nanotechnology For Biomedical Applications, Tracy L. Mallette

Biomedical Engineering ETDs

In the past 30 years, there have been major advancements on how to treat and diagnose disease because of the improvement and increase in accessibility of sequencing technology. Nucleic acid-based therapeutics can manipulate protein expression. Likewise, pathogens can be identified and detected with single nucleotide specificity. However, the underlying oligonucleotide technology requires protection against natural defense systems that have evolved to destroy foreign nucleic acids. Many chemical modifications that can protect nucleotides also have significant cytotoxic side effects and must be carefully designed into the strands. A novel way to protect against nuclease-mediated degradation is through the use of mirror-image, …

Queer Crises: Movements From Queerness And Feelings Of White Religion In The United States, Austin Williams Miller

Communication ETDs

Anchored by contemporary crises surrounding queer and trans people in the United States, I employ movements from queerness within an affective queer phenomenological framework to understand how arrangements of “white religion” (Schaefer, 2015, p. 63), a process whereby U.S. American Christian forms escape ideology into religious affective economies in the United States, relegate queer people “to the background… to sustain a certain direction” (Ahmed, 2006, p. 31). I assemble a queer rhetorical context analyzing white religious space in documentary film, secular sexual regulation through contemporary U.S. legal contexts around marriage, and settler colonial Christian nationalist political imaginations to critique how …

Slavery And Architecture Across The Mediterranean, John Behnken

History ETDs

Enslaved people as architectural material, found in the cultural examples of the Great Mosque of Cordoba and the Hagia Sophia, provide a lens from which scholars can re-envision the historical narrative. The scholarship surrounding the development and transition of the Great Mosque of Cordoba from a mosque to a church, elicits new research into what medieval people thought about race, race-making, and cultural ownership. The conceptions of race are evident through the medieval paradigms of enslavement. Who could and could not become enslaved establish social, cultural, and phenotypic classifications which in turn become race. The work of scholars such as …

Resistance Narratives: Storytelling Of Transnational Insurgencies In 1960-70s Us And Mexico, Tania Libertad Balderas

English Language and Literature ETDs

Resistance Narratives: Storytelling of Transnational Insurgencies in 1960-70s US and Mexico emphasizes how the narratives from the Mexican Insurgency, the American Indian Movement (AIM), and the leftist faction of the Chicana/o Movement in the 1960s and 1970s articulate intersecting notions of resistance, liberation, and transnational solidarity. The comparative analysis of the testimonial novel Las mujeres del alba (2019) by Chihuahuan novelist Carlos Montemayor, the autobiographies Lakota Woman (1991) and Ohitika Woman (1993) by Sičháŋǧu Lakȟóta writer and AIM militant Mary Brave Bird (formerly Crow Dog), and the memoirs and plays by the San Diego-based group Teatro de las Chicanas, collected …

The Water Mills Of The Historic Río Arriba In Northcentral New Mexico, 1598-1975, José A. Rivera Ph.D, Thomas F. Glick Ph.D

Faculty Publications

The water mills of New Mexico played a major role in the agricultural economy of the Río Arriba for centuries following the introduction of wheat from the Old World to the Americas. Wheat, in its ground form as flour, was a staple during the Spanish colonial period. To process raw wheat, local grist mills (molinos) were essential infrastructure as were the aceq uias (ditches) that powered them. Situated near the banks of rivers, the internal components of each mill were driven by the gravity force of water from an acequia, itself diverted from the river. Researchers have documented …

Electromagnetic Simulations Of The Lansce Chopper Structure, Yusuf Sahin

Electrical and Computer Engineering ETDs

Particle accelerators are important for basic research as well as in applications such as ion implantation and cancer therapy. One important accelerator is the Los Alamos Neutron Science Center (LANSCE) located at Los Alamos National Laboratory (LANL) that primarily produces neutrons for research. The beam chopper simulation described here is a study to provide better modeling of this subsystem of LANSCE. A chopper is a device in which particles are intermittently sliced and directed to a target and/or experiment. The simulations in this thesis are used to analyze the correct operating parameters of the chopper. A good chopper model can …

The Third Domain Of T Cells In The Evolution Of Novel Immune Cell Types, Kimberly Anne Morrissey

Biology ETDs

αβ and γδ T cells play an essential role in the adaptive immune response and are present in the majority of jawed vertebrates. The T cell receptor (TCR) structure and genetic organization have been generally stable throughout 400 million years of gnathostome evolution. However, the TCRδ chain has displayed degrees of plasticity unseen in other TCR isoforms. One such form appears to be a chimera of a TCR chain with an antibody-like binding domain, known as VHδ and has been found a wide array of vertebrates including cartilaginous fish, coelacanths, amphibians, tuataras, birds, crocodilians, and monotreme mammals. Another, more extreme …

Investigating The Costs And Benefits Of A Nutritional Fungal Endosymbiont, Nolan L. Perryman

Biology ETDs

Research on insect symbiosis is dominated by insect–bacteria models, however, the role of fungal symbionts in insects is poorly understood. Fungi are de novo synthesizers of many essential nutrients, therefore, insect–fungal pairings can permit specialization on nutritionally deprived diets. Here, I address the costs and benefits of symbiosis using a system of beetle–fungal symbiosis. Specifically, I ask 1) when reared on a low-quality diet, does the beetle increase the number of viable symbionts to compensate for a heightened nutritional demand, and 2) Is the conferred fitness benefit of the symbiont only present in low-quality diets? When reared on low-quality diets, …

Neutrosophic Bwm-Topsis Strategy Under Svns Environment, Surapati Pramanik, Suman Das, Rakhal Das, Binod Chandra Tripathy

Neutrosophic Sets and Systems

No abstract provided.

Law Of Included Infinitely-Many-Middles Within The Frame Of Neutrosophy, Florentin Smarandache

Neutrosophic Sets and Systems

No abstract provided.