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I Progress Towards The Synthesis Of Plakortether B Through A Zinc-Mediated Homologation Ii Synthesis Of Novel Hydroxy-Cyclopropyl Peptides Isosteres, Ian Scott Taschner

Doctoral Dissertations

A streamlined synthetic pathway to target the core of plakortether B through a zinc-mediated homologation-aldol reaction has been developed. This chemistry was performed on a chiral beta-keto amide, which was synthesized in a few steps. In a one-pot reaction the beta-keto amide could be converted into a furanyl-ketal with high stereocontrol at two chiral centers. The homologation-aldol reaction was followed by a cyclization-allylation to obtain the plakortether backbone.

During the synthesis of plakortether B, a serendipitous byproduct was identified as a [3.1.0] bicyclic lactone. The lactone was seen as a precursor to a peptidomimetic that would contain an embedded hydroxycyclopropyl …

Independently Innovative: Teachers And Change In Successful Schools, Mary Halpin Carter

Doctoral Dissertations

This study explores teachers' perceptions of school change and leadership. The study is guided by the question: In an innovative independent school, how do teachers perceive deliberate change efforts and relate to the leaders who lead them. Other issues considered are the role of school culture, professional development and institutional goals in an effective change process. This research is distinctive in that it examines school change from the teachers' perspective and was conducted in a school that had previously demonstrated positive growth. The result is a qualitative, case study of one exemplary, independent school.

In the summer and fall of …

Examining The Relationship Between Social Capital And The Built Environment: A Case Study In Measuring Community Sustainability, Shannon H. Rogers

Doctoral Dissertations

The concepts of sustainability and sustainable development are frequently described as having three main components, sometimes referred to as the three pillars or the triple bottom line: environmental, economic, and social. Because the origins of sustainability come from a desire to right environmental wrongs much consideration has been given to the environmental issues, especially how they interface with economic ones. Frequently mentioned but rarely examined, the social aspects of sustainability have been considered the weakest and least described pillar. This work explores the utility of social capital, the value of one's networks and connections, as a measure of sustainability. As …

Satellite-Derived Fluorescence Quantum Yields As Indicators Of Phytoplankton Photophysiology, Deborah Goodwin

Doctoral Dissertations

Understanding and quantifying phytoplankton physiological variability is essential for analyses of biogeochemical cycling, climate change and ecosystem processes. Satellite measurements of chlorophyll indicate phytoplankton biomass but hold minimal direct information about the organisms' photosynthetic capabilities: however, remote sensing-derived fluorescence quantum yields have the potential for monitoring phytoplankton photophysiological states on a global scale. Recent research has demonstrated the effects of both nutrient stress and photoacclimation on fluorescence yield. Here, a novel satellite product comprising seven years of fluorescence quantum yields, derived from MODIS/Aqua normalized fluorescence line heights and corrected for pigment packaging effects, is evaluated and explored. Fluorescence yields are …

From Sweetwater To Seawater: An Environmental History Of Narragansett Bay, 1636--1849, Christopher L. Pastore

Doctoral Dissertations

This dissertation examines environmental change on and around Narragansett Bay from first European settlement in 1636 to the dissolution of the Blackstone Canal Company in 1849. It uses one of the largest estuaries on the East Coast and one situated at the heart of early English settlement in New England as a means to write estuaries into Atlantic history. Examining the ecological and epistemological complexities that arose at the nexus of land and sea, where improvable space and the push of "progress" met an eternal or "profound" ocean, this study reframes estuaries as watery borderlands that people used but never …

Detection Of Mortality In Tropical Forests Using Remote Sensing: From Treefall Gaps To Large Disturbances, Fernando Del Bon Espirito-Santo

Doctoral Dissertations

The frequency, severity, and intensity of natural disturbances in tropical forests continually re-shape forest structure. At small scale, branch or tree-falls gaps and subsequent recovery are important mechanisms for carbon cycling. At landscape scale, large disturbances (blow-downs) may also play a role on the structure and composition of tropical forests. Quantitative studies of natural disturbances across the occurrence spectrum (branch fall-gaps to blow-downs) are rare for the Amazon. Remote sensing coupled with intense field work data collection provides the means to analyze the dynamic of tropical forests at multiple scales. In this dissertation three aspects of natural disturbances were examined: …

In-Situ Early Detection Of Metal Corrosion Via "Turn-On" Fluorescence In "Smart" Epoxy Coatings, Anita Augustyniak

Doctoral Dissertations

Organic coatings (e.g., epoxy coatings) have been widely used to protect metal and metal alloys against corrosion. However protective coating fails with time, leading to corrosion of the metal substrate. When localized corrosion occurs, without being detected, it can result in disastrous failure of the metal structure. The purpose of this thesis is to develop a "smart" epoxy coating system that detects early stages of metal corrosion via indicators molecules embedded in the coating that fluoresce when triggered by ions liberated from corrosion. This fluorescence can be easily and non-destructively detected and thus further material damage can be prevented by …

A Computational Fluid Dynamics Study Of Two-Phase Flows In The Presence Of Surfactants, Yuanyuan Cui

Doctoral Dissertations

Drop formation in co-flowing fluids and drops rising in a tube are important in applications such as microencapsulation and enhanced oil recovery. A hybrid volume-of-fluid method with a front-tracking scheme is developed to study two-phase flows in the presence of surfactants at finite Reynolds numbers. Both fluids can be Newtonian or shear-thinning, and surfactants are soluble in the adsorption-desorption limit. A drop in the co-flowing geometry typically breaks up at the primary neck. The drop breaks faster with smaller volumes as the outer flow rate increases or the drop viscosity decreases. When surfactants are present, they accumulate in the neck …

Character Displacement In Burkholderia Biofilm Communities And The Effect Of Adaptive History On The Evolution Of Niche Breadth, Crystal Nicole Ellis

Doctoral Dissertations

Ecologists agree that biodiversity is essential for maintaining highly productive and stable ecosystems, yet the mechanisms that generate and preserve diversity are unknown in many habitats. Competition for shared resources may cause selection to favor niche specialization, which reduces competition and reinforces diversity. If the environment is significantly altered, the ecological history of the remaining colonizer may influence fitness and capacity for diversification in new environments. In many cases, specialists have limited adaptive potential due to trade-offs generated by niche-specific adaptation; however, generalists may be adaptable in many habitats, which would make them good pioneer species for colonization. We investigated …

Unraveling The Mystery Of Leaf Reddening In Seagrasses, Alyssa B. Novak

Doctoral Dissertations

Seagrass meadows around the world are declining due to natural and anthropogenic stressors, including global climate change. Recently, more attention has been given to identifying responses that offer resistance to stressors so that researchers can better manage seagrasses for resilience to environmental change. Leaf reddening, the expression of red coloration in leaves, is a well-documented response in terrestrial plants that has been shown to increase resilience to stress, but has been poorly understood in seagrasses. To increase our understanding of the prevalence, causes, and function of leaf in seagrasses, surveys were conducted in the world's six seagrass bioregions and a …

Study Of The Rate And Spectrum Of Spontaneous Mutations, Way Sung

Doctoral Dissertations

Mutations are the initial force responsible for all aspects of genetic variation, and are a central part to evolution in all organisms. Yet despite its importance, the previously high cost that is associated with surveying mutations at a genome-wide scale has limited the understanding of the mutation process in eukaryotes. However, recent high-throughput sequencing technology has greatly reduced the cost of surveying mutations. By applying high-throughput sequencing to mutation accumulation experiments, we have begun to characterize the genome-wide mutation spectrum of eukaryotes.

Across all eukaryotes, we observe a biased rate of G/C-> A/T mutations that exceeds the number of A/T- …

The Implications Of Socioeconomic Status And A Usual Source Of Care For The Health And Health Care Experiences Of Elders With Chronic Illnesses, Michelle L. Stransky

Doctoral Dissertations

Recently developed models of health care provision have promoted the relationship between providers and patient for improving care continuity and coordination. This may be especially important for the growing population of elders, who often have fragmented care because of multiple chronic illnesses. Previous research shows that elders who have a usual source of care (USC) have better health and health care experiences than other elders. However, research has rarely considered whether the benefits of USCs may be affected by the elder's socioeconomic status (SES), their levels of chronic illness, or various provider characteristics.

This dissertation utilizes the 2007 Medicare Current …

I The Synthesis Of Papyracillic Acids: Application Of The Tandem Chain Extension-Acylation Reaction Ii Diastereoselective Synthesis Of Beta-Methyl-Gamma-Keto Esters Through The Utility Of An L-Serine Auxiliary, Jennifer R. Mazzone

Doctoral Dissertations

The development of the zinc-mediated tandem chain extension-acylation reaction for the synthesis of spiro-fused ketals was successfully accomplished. The incorporation of a methyl-substituent into the gamma-keto ester backbone, through a methyl substituted carbenoid, allowed for the synthesis of papyracillic acid B and 4-epi-papyracillic acid C. Comparison between the reported and experimental spectral data for papyracillic acid B and 4- epi-papyracillic acid C permitted structural and stereochemical reassignment.

Diastereoselective syntheses of beta-methyl-gamma-keto esters were achieved through the utility of an L-serine auxiliary. Preparation of a series of L-serine derived precursors were prepared and studied.

Artifact-Based Reflective Interviews For Identifying Pragmatic Epistemological Resources, Christopher Walden Shubert

Doctoral Dissertations

Physics Education Research studies the science of teaching and learning physics. The process of student learning is complex, and the factors that affect it are numerous. Describing students' understanding of physics knowledge and reasoning is the basis for much productive research; however, such research fails to account for certain types of student learning difficulties. In this dissertation, I explore one source of student difficulty: personal epistemology, students' ideas about knowledge and knowing.

Epistemology traditionally answers three questions: What is knowledge? How is knowledge created? And, how do we know what we know? An individual's responses to these questions can affect …

Assessing Social-Ecological Resilience And Adaptive Capacity In The Face Of Climate Change: An Examination Of Three Communities In The Crown Of The Continent Ecosystem, Bradley B. Johnson

Doctoral Dissertations

This research examines the social-ecological resilience and adaptive capacity of the Crown of the Continent Ecosystem through a suite of three case study communities and the impacts of climate change on the ecosystem's hydrologic regime. The Crown of the Continent Ecosystem spans the U.S.-Canadian border; case study communities composed of Kalispell and Choteau, Montana and Fernie, British Columbia fall on both sides of the border.

Primary data was gathered through a "bottom-up" qualitative approach utilizing an online survey followed by a semi-structured interview process with stakeholders in natural resource dependant industries and government at the local, state, and federal levels …

High Lundquist Number Simulations Of Parker's Model Of Coronal Heating: Scaling And Current Sheet Statistics Using Heterogeneous Computing Architectures, Liwei Lin

Doctoral Dissertations

Parker's model [Parker, Astrophys. J., 174, 499 (1972)] is one of the most discussed mechanisms for coronal heating and has generated much debate. We have recently obtained new scaling results for a 2D version of this problem suggesting that the heating rate becomes independent of resistivity in a statistical steady state [Ng and Bhattacharjee, Astrophys. J., 675, 899 (2008)]. Our numerical work has now been extended to 3D using high resolution MHD numerical simulations. Random photospheric footpoint motion is applied for a time much longer than the correlation time of the motion to obtain converged average coronal heating rates. Simulations …

An Exploratory Approach To Social Impact Assessment Of Public Policy Decisions: Multiple Stakeholders Perspectives On The Social Impact Of Overfishing In New England Groundfisheries In The 1990s, Fabienne Lord

Doctoral Dissertations

This thesis seeks to understand how stakeholders' perspectives and understanding of social impacts influence decision processes. Understanding stakeholders' comprehension of social impacts provides insight as to how they weigh these impacts against others when making decisions. Moreover, the way stakeholders influence, or are influenced by, management decisions provides information on the use and development of methodologies successful in assessing social impacts and communicating the results. Built on this information, the main objective is to explore and develop a Social Impact Assessment (SIA) approach that could capture and integrate multiple stakeholders' perspectives in predicting impacts from ongoing, renewable resource management actions. …

Polyamine Metabolism In Arabidopsis: Transgenic Manipulation And Gene Expression, Rajtilak Majumdar

Doctoral Dissertations

The metabolism of polyamines (Putrescine, Spermidine and Spermine) in wild type and transgenic Arabidopsis thaliana (Col 0 ecotype) plants was studied using the techniques of transgenic manipulation and gene expression. Two specific objectives were: (1) To study the effects of inducible and constitutive transgenic manipulation of polyamines via a mouse ornithine decarboxylase (mODC) gene on plant metabolism. (2) To analyze the spatial and temporal expression patterns of Arabidopsis thaliana S-adenosylmethionine decarboxylase genes (AtSAMDC3, AtSAMDC4 and AtSAMDC5) during its life cycle.

The major findings are: (i) Orn becomes a limiting substrate for Put biosynthesis in transgenic Arabidopsis expressing mODC gene, (ii) …

Testing Of Great Bay Oysters For Two Protozoan Pathogens, New Hampshire Fish And Game Department, Douglas E. Grout

PREP Reports & Publications

Two protozoan pathogens, Haplosporidium nelsoni (MSX) and Perkinsus marinus (Dermo), are known to be present in Great Bay oysters. With funds provided by the Piscataqua Region Estuaries Partnership ( PREP ), the Marine Fisheries Division of the New Ham pshire Fish and Game Department (NHF&G) continues to assess the presence and intensity of both of these disease conditions in oysters from the major beds within the Great Bay estuarine system. Histological examination s of Great Bay oysters have also revea led other endoparasites.

University Of New Hampshire Undergraduate Course Catalog, 2011-2012, University Of New Hampshire

Undergraduate Catalog

No abstract provided.

First And Second Majors In Baccalaureate Programs (Spring Semester Counts) Durham And Manchester Degree Candidates Ten Years, 2002-2011, University Of New Hampshire. Institutional Research And Assessment

UNH Factbooks

University of New Hampshire factbook data from the 2010-2011 academic year

Graduate Degree Completions, 2001-2010, University Of New Hampshire. Institutional Research And Assessment

UNH Factbooks

University of New Hampshire factbook data from the 2010-2011 academic year

Associate Degree Completions, 2001 - 2010, University Of New Hampshire. Institutional Research And Assessment

UNH Factbooks

University of New Hampshire factbook data from the 2010-2011 academic year

The Foster Parent Experience Of Attachment, Taylor Cohen

Master's Theses and Capstones

This study explores the attachment experience of foster parents. The researcher used a qualitative research framework to explore what 10 foster parents experienced in regards to attachment with their foster children. Based on the data and content analysis, a foster parent ecology emerged showing that the foster parent/child attachment relationship is affected by doctors, therapists, social workers, case workers, other foster parents, and the biological parents. The temporary nature of foster care and the goal of reunification of child to biological parent also affected the attachment relationship between foster parent and foster child.

The Effect Of Suspended Solids During Uv/Hydrogen Peroxide Advanced Oxidation Of Municipal Wastewater, Laith Furatian

Master's Theses and Capstones

As wastewater and water reuse practices evolve to meet changing effluent requirements, the capabilities of various technologies to achieve treatment objectives merit investigation. This work examines the influence of suspended solids on the efficiency of the UV-H2O2 advanced oxidation process to affect oxidation of organic contaminants in biologically wastewater effluents. Effluent samples from two conventional activated sludge plants were used to produce microfiltrates with 0.2 mum nylon filters. Para-chlorobenzoic acid (pCBA) was used as a probe compound to indirectly quantify the steady state OH concentration in samples spiked with H2O2 and irradiated using a bench-scale UV collimated beam apparatus. An …

High Energy Routes To Reactive Intermediates: Computational And Experimental Studies, Aida Ajaz

Master's Theses and Capstones

We developed microwave flash pyrolysis (MFP), using graphite and other sensitizers to carry out high temperature reactions. Newly developed is a closed vessel MFP method. Studies to date include isomerization of azulene to naphthalene, generation of benzyne, cycloaromatizations, and rearrangements. New thermal sensitizers included silicon carbide, titanium dioxide and diverse metal oxides. Graphite remains the most effective thermal sensitizer. Sealed tube MFP was utilized to investigate the Brown rearrangement of aryl alkynes. CCSD(T)//M05-2X computations have been carried out for both concerted and stepwise mechanisms in dehydro-Diels-Alder reactions of ethene and ethyne with vinylacetylene and 1,3-butadiyne. Concerted transition states for enyne-ene …

Addition Of Sodium Bicarbonate To Colostrum: Effects On Igg Absorption And Hematocrit In Neonatal Calves, Colleen E. Chapman

Master's Theses and Capstones

Twenty-six Holstein bull calves born from primiparous and multiparous cows without dystocia were assigned to a randomized complete block design to one of two treatments within each block: colostrum with no supplemental sodium bicarbonate or colostrum with 30 g of supplemental sodium bicarbonate. Calves were fed colostrum from nine different batches with an immunoglobulin G (IgG) concentration of 82.05 +/- 8.45 g/L and the total amount of IgG fed of 329.89 +/- 34.56 g at 0 h and 6 h postpartum. Calves were fed 2 L of milk replacer (MR) at 24, 36, and 48 h postpartum. The addition of …

An In Vitro Technique To Estimate Digestibility Of Amino Acids In Dairy Cattle Feeds, Scott Joseph Talbot

Master's Theses and Capstones

Three soybean meal (SBM), 3 SoyPlusRTM (SP), 5 dried distillers' grains with solubles (DDGS), and 5 fishmeal (FM) were obtained from FeedAC, Inc. (Homer, NY) and along with 5 cornsilage hybrid samples (CS), were used in an experiment to calculate total tract digestibility of crude protein (CP) and amino acids (AA). An in vitro procedure was used that incorporated the modified three step procedure (mTSP) developed by Calsamiglia and Stern (1994) and then modified by Gargallo et al. (2006) and the protease incubation procedure developed by McNiven et al. (2001) which replaces the in situ rumen incubation step in the …

Comparing The Sustainability Of Two Surface Water Treatment Alternatives Using Life Cycle Assessment (Lca), Michaela L. Bogosh

Master's Theses and Capstones

A sustainability assessment which combines the academic strengths of university research modeling with the practical inputs and needs of an operating utility is presented to compare two water treatment alternatives. PWN Water Supply Company is evaluating an upgrade from their current conventional coagulation and sand filtration (CSF) treatment process at WTP Andijk to Suspended Ion Exchange with Ceramic Microfiltration (SIX/CeraMac). An initial LCA was performed to determine which pretreatment is more sustainable in terms of energy consumption and carbon footprint.

The initial LCA indicated that treatment with SIX/CeraMac exhibits a lower impact as measured by kg of carbon dioxide equivalents …

Incidence, Abundance, Post-Harvest Processing And Population Diversity Of Pathogenic Vibrios In Oysters From The Great Bay Estuary, Jong Whan Yu

Master's Theses and Capstones

Shellfish-borne vibrio diseases have increased recently in the US, particularly in cooler, northern areas. Harvest area monitoring and post-harvest processing (PHP) have been implemented to reduce Vibrio disease risks in marketed shellfish, and rapid and reliable detection methods are needed to assess these risks. Both culture based and qPCR detection methods were useful for detecting V. parahaemolyticus (Vp) in oysters. QPCR is more rapid and less subjective, while the culture based method allowed detection of lower Vp concentrations in cold-water oysters where the Vp population diversity was more clonal. Depuration and relaying were assessed as PHP strategies for reducing Vp …