Digital Commons Network^™

Machine Learning Prediction Of Primary Tissue Origin Of Cancer From Gene Expression Read Counts, Lohitha Chintham Reddy

UNLV Theses, Dissertations, Professional Papers, and Capstones

Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells. Generally, manufacturing of proteins by cells is controlled by genes. Each gene must have the correct instructions for making its protein, so that it allows the protein to perform the correct function for the cell. When one or more genes in a cell mutate and create an abnormal protein, that is when cancer begins. An abnormal protein provides different information compared to a normal protein. This can cause cells to multiply uncontrollably and cause cancer.

RNA sequencing (RNA-seq) can be used to figure out …

Equation Of State Of H2o Ice Using Melt-Recrystallization, Zachary Michael Grande

UNLV Theses, Dissertations, Professional Papers, and Capstones

The recent surge in exoplanet discoveries due to advancements in astrophysical technology and analysis has brought the reliability of early equation of state measurements into question as they are the limiting factor when modeling composition of these planets. H2O content is among the most important for the search of habitable planets as well as in understanding planetary dynamics and atmosphere formation. Over the last three decades the equation of state of H2O has been investigated with various techniques but, has suffered from anisotropic strain and poor powder statistics resulting in a large discrepancy in equation of state fits. At pressures …

Numerical Study Of Spacer Grid Geometry In A 5 X 5 Nuclear Fuel Rod Bundle, Wan Chuan Fan

UNLV Theses, Dissertations, Professional Papers, and Capstones

Reactor fuel rod bundles serve as the primary heat source in light water reactors (LWRs), commonly found in the aforementioned PWR plants. The fuel rod bundles’ structure consists of a collection of fuel rods put into a parallel grid configuration. The bundles also include fuel rod spacers, which hold the fuel rods in place, in accordance with the grid. Repeating structures of the fuel bundles create the meta-structure in the reactor. In other words, the grid configuration repeats until it fills the entire space of the reactor. This results in reactor fuel rods suspended in the working fluid domain, oriented …

Machine Learning Classification Of Primary Tissue Origin Of Cancer From Dna Methylation Markers, Sravani Gannavarapu Surya Naga

UNLV Theses, Dissertations, Professional Papers, and Capstones

Cancer is one of the leading causes of death globally and was responsible for approximately 9.6 million deaths in 2018. One of the main reason for deaths from cancer is late-stage presentation and inaccessible diagnosis and treatment. Cancer often spreads from the part of the body where it started (primary site) to a different part of the body (metastatic site). Identifying the primary site of cancer plays a key role as it directs the appropriate treatment. Cancer which spreads needs the same treatment as its origin. Having this knowledge can help doctors to decide the type of treatment.

All cancers …

Analysis Of Bitcoin Cryptocurrency And Its Mining Techniques, Suman Ghimire

UNLV Theses, Dissertations, Professional Papers, and Capstones

Bitcoin is a peer-to-peer digital, decentralized cryptocurrency created by an individual under pseudonym Satoshi Nakamoto. In fact, it is the first digital, decentralized currency. Several developers and organizations have explored the importance of digital cryptocurrency and the concept of the blockchain. Bitcoin is assumed to be one of the secure and comfortable payment methods that can be used in the upcoming days. The backbone of Bitcoin mining is the concept of the blockchain, which is assumed to beone of the ingenious invention of this century. The blockchain is the collection of blocks that are linked together in such a way …

Numerical Analysis And Fluid Flow Modeling Of Incompressible Navier-Stokes Equations, Tahj Hill

UNLV Theses, Dissertations, Professional Papers, and Capstones

The Navier-Stokes equations (NSE) are an essential set of partial differential equations for governing the motion of fluids. In this paper, we will study the NSE for an incompressible flow, one which density ρ = ρ0 is constant.

First, we will present the derivation of the NSE and discuss solutions and boundary conditions for the equations. We will then discuss the Reynolds number, a dimensionless number that is important in the observations of fluid flow patterns. We will study the NSE at various Reynolds numbers, and use the Reynolds number to write the NSE in a nondimensional form.

We will …

Telomeres, Nutrition And Mortality: Risk Factors For The Rate Of Telomere Length Decline And The Associations Between Telomere Length, Nutrition And Mortality, Saruna Ghimire

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: Telomeres are nucleoprotein structures located at the ends of eukaryotic chromosomes, thought to protect the DNA from damage. As a person experiences stressors, harmful exposures, and other diseases throughout their life, telomeres are thought to become damaged and their length shortened, decreasing their ability to protect the DNA. Nutrition is an important aspect of healthy aging. Preservation of telomere length (TL) is thought to be one of the mechanisms by which good nutrition can delay or prevent the development of chronic disease and death. Recent evidence of preservation of TL with good nutrition is promising. Thus, the aim of …

The Effects Of Sex Role Stereotype Endorsement And Work-Family Conflict On Emerging Adult Aspirations, Andrea Fink-Armold

UNLV Theses, Dissertations, Professional Papers, and Capstones

Workplace and household inequality remain prevalent in the United States and sex role (e.g. breadwinner and caregiver) stereotypes affect the roles that individuals seek out. This research used a mixed-methods approach to investigate the effects of sex role stereotypes and expected work-family conflict on the work and family aspirations of emerging adults. A racially diverse sample wrote freely about their future selves for ten minutes then completed measures to evaluate their sex-role stereotype endorsement, expected work-family conflict, and personal preferences for career and family roles. Results indicate that endorsement of stereotypes predicts increased expectations of work-family conflict, for both men …

Implications Of An Iterative Design Experiment In Transcendental And Polynomial Functions Within A Flipped Classroom, Aaron Boyd Harris

UNLV Theses, Dissertations, Professional Papers, and Capstones

This study explores an iterative design research experiment of a flipped mathematics classroom over the span of five curricular units involving big ideas of transcendental and polynomial functions. Transcendental and polynomial functions involve an algebraic, analytic, and graphical approach to the concepts and procedures of exponential, logarithmic, power, cubic, quadratic, linear, and rational functions. The Compleat design research methodology (Middleton, Gorard, Taylor, & Bannan-Ritland, 2008) was used to explore a series of instructional sequences that an instructor implemented in a flipped classroom while teaching big ideas of transcendental and polynomial functions.

The experiment occurred over the course of a sixteen-week …

K-Tuple Sampling From Partially Rank-Ordered Sets, Marvin Javier

UNLV Theses, Dissertations, Professional Papers, and Capstones

With the introduction of Ranked Set Sampling (RSS), McIntyre (1952) demonstrated that using ranking information to select units for measurement can lead to estimators with reduced variance when compared to their counterparts based on a simple random sample of the same size. This is done by selecting a set of units, and without direct measurement, ranking the units in the set before identifying one unit for measurement. This ranking of the units can be done through judgement ranking (such as visual assessment), or by using a correlated auxiliary variable.

In its original form, RSS does not allow for ties when …

Examining The Role Of Business Intelligence And Analytics In Hospitality Revenue Management, Anna I. Kharitonova

UNLV Theses, Dissertations, Professional Papers, and Capstones

Most hospitality revenue management forecasting systems were built prior to the business intelligence and analytics movement. Only recently these systems have been enhanced to offer contemporary business intelligence and analytics functionalities. In addition, revenue management professionals are receiving support from standalone, supplementary business intelligence and analytics platforms. The purpose of this dissertation was to produce a holistic review of and establish the role of business intelligence and analytics within hospitality revenue management. Data was collected from twenty-three interviews; all participants were employed by hospitality organizations in revenue management specific positions. Grounded theory methodology was utilized. The results show that nearly …

A Monolithic Arbitrary Lagrangian-Eulerian Finite Element Method For An Unsteady Stokes/Parabolic Interface Problem, Ian Kesler

UNLV Theses, Dissertations, Professional Papers, and Capstones

In this thesis, a non-conservative arbitrary Lagrangian-Eulerian (ALE) method is developed

and analyzed for a type of linearized Fluid-Structure Interaction (FSI) problem in a

time dependent domain with a moving interface - an unsteady Stokes/parabolic interface

problem with jump coefficients. The corresponding mixed finite element approximation is

analyzed for both semi- and full discretization based upon the so-called non-conservative

ALE scheme. The stability and optimal convergence properties in the energy norm are

obtained for both schemes.

Batching Problems With Constraints, Shradha Kapoor

UNLV Theses, Dissertations, Professional Papers, and Capstones

There is an increasing demand for a phenomenon that can manifest benefits gained from grouping similar jobs together and then scheduling these groups efficiently. Batching is the decision of whether or not to put the jobs into same group based on certain criteria. Batching plays a major role in job scheduling in Information Technology, traffic controlling systems, and goods-flow management. A list batching problem refers to batching a list of jobs in the same order or priority as given in the problem.

In this thesis we consider a one-machine list batching problem under weighted average completion. Given sequence of jobs …

Private Group Communication In Blockchain Based On Diffie-Hellman Key Exchange, Zachary Steven Laney

UNLV Theses, Dissertations, Professional Papers, and Capstones

Our research proposes a solution to establishing a private group encryption channel so that users may communicate securely according to NSA security standards. There are many techniques that are used to establish a private encryption channel between two users, but there are no encryption protocols currently available that are built to establish a private communication channel with an unlimited amount of users at once via the open distributed blockchain. Our solution demonstrates how a web interface allows any individual to publish a Public Key, a Wallet Address, and an Email Address to a smart contract which enables a private group …

Petrogenesis Of The El Rechuelos Rhyolite, Jemez Mountains Volcanic Field, New Mexico, Usa, Kelsy Jo Konkright

UNLV Theses, Dissertations, Professional Papers, and Capstones

The El Rechuelos Rhyolite represents volcanic activity preceding the multiple caldera collapse events of the Jemez Mountains volcanic field (JMVF) in northern New Mexico. This study focuses on seven rhyolitic units clustered north of the Valles caldera. These units have been studied in order to interpret their relationships to one another and the eruptive history of the JMVF. Additionally, this study adds to the research on the relationships between effusive and explosive rhyolitic volcanism, and understanding how caldera-forming eruptions develop from silicic systems.

Limited previous research includes K/Ar dates and a few inconsistent 40Ar/39Ar dates, in addition to whole rock …

Utilization Of Remote Sensing Data For Estimation Of The Groundwater Storage Variation, Gaurang Mistry

UNLV Theses, Dissertations, Professional Papers, and Capstones

Groundwater is the most extracted raw material, with an average withdrawal rate of 982 km3 per year, where 70 percent of the total groundwater withdrawn is used for agriculture globally (Margat & van der Gun, 2013). With climate change and increased water demands in recent years, monitoring the changes in the groundwater storage is of the utmost importance. This thesis presents an analysis that determines the rates, trends, and directions where groundwater storage is going in Pakistan. It also correlates fluctuations in groundwater storage with variations in precipitation and agricultural productivity in the country. The overall objectives of this thesis …

Specific Heat, Magnetic Susceptibility, And The Effect Of Pressure On Structural Properties And Valence Of Eumn2si2, Euco2si2, And Eu5in2sb6, Brian Edward Light

UNLV Theses, Dissertations, Professional Papers, and Capstones

Many intermetallic solids containing elements from the rare earth series show interesting and unusual behavior associated with 4f electrons. This behavior includes unusual magnetic order, strongly correlated electrons, intermediate valence, heavy fermions, the Kondo effect, superconductivity, and non-Fermi liquid (NFL) to name a few. When long range magnetic order is suppressed to T = 0 K by the application of an external tuning parameter such as pressure, magnetic field, or chemical doping, a quantum critical point (QCP) appears in which strong quantum fluctuations give rise to many of the mentioned unusual properties.

Most of the past studies on unusual 4f …

Stop Running In Laps: Evaluating The Lethality Assessment Program's Effectiveness In Reducing Repeat Intimate Partner Violence, Dory A. Mizrachi

UNLV Theses, Dissertations, Professional Papers, and Capstones

Repeat victimization is a phenomenon which is generally understood as the pattern and prevalence of victimization. This is an important factor for local authorities in their attempt to develop innovative policies and practices to facilitate predicting and preventing crimes. Thus, many police departments around the country, including the Las Vegas Metropolitan Police Department (LVMPD) have adopted the Lethality Assessment Program (LAP). This is a risk assessment tool used by responding officers on domestic violence calls that intends to prevent future risk of lethal violence to victims of domestic violence by assessing their risk of lethality and providing immediate referrals to …

Acr Accreditation For Utah Valley Hospital’S Radiation Oncology Center, Remy Manigold

UNLV Theses, Dissertations, Professional Papers, and Capstones

Becoming an accredited clinic through the American College of Radiology (ACR) and their Radiation Oncology Practice Accreditation (ROPA) program will provide third-party evaluation of patient care to ensure the best treatment possible for patients.

Talk of getting ACR accreditation has occurred in the past for Utah Valley Hospital/American Fork Hospital, but at the time it was seen as something that did not provide sufficient value vs. the cost. The recent One Intermountain restructuring is intended to unify all of the Intermountain Healthcare radiation oncology centers in Utah so the Radiation Oncology Director has set the goal that all Intermountain radiation …

Effects Of Ecological Restoration Techniques In Glen Canyon National Recreation Area, Simone Ka-Voka Jackson

UNLV Theses, Dissertations, Professional Papers, and Capstones

A better understanding of key ecological restoration techniques can inform land management in the Southwest on restoration options for areas infested by invasive grasses that can pose threats to ecosystems, from changes in nutrient cycling to altered fire regimes. In the semi-arid desert of Glen Canyon National Recreation Area (GLCA), several exotic grasses pose risks to local ecosystems: Saccharum ravennae, a relatively new invasive perennial grass, and Bromus rubens and Bromus tectorum, widespread annual grasses. In this study, multiple ecological restoration techniques were implemented to assess their effects on native and nonnative vegetation on sites invaded by the non-native grasses …

Implementing A Heart Failure Education Program For Bedside Nurses In The Acute Care Setting, David L. Morrow

UNLV Theses, Dissertations, Professional Papers, and Capstones

Heart failure is a chronic disease in which a weakened heart is no longer able to deliver adequate blood flow to supply the body with needed oxygen and nutrients. Heart failure is the most common reason for hospitalization in the United States for patients age 65 and over, accounting for over 1,000,000 hospital admissions annually. Due to the chronic nature of this debilitating condition and associated symptoms, patients discharged from the hospital with a diagnosis of heart failure are at high risk for readmission. Effective self-care behaviors have been shown to reduce readmissions and improve quality of life for these …

Potential Fossil Yield Classification (Pfyc) Survey Of Nevada Surficial Geology, And A Multi-Sensor, Remote Sensing, Change-Detection Study Of Land-Use/Land-Cover Urbanization Impacting The Las Vegas Formation Located In Northwestern Las Vegas Valley, John Jayson Medema

UNLV Theses, Dissertations, Professional Papers, and Capstones

This thesis is a combination of two separate but related projects. The first project is a Potential Fossil Yield Classification (PYFC) survey. The PFYC is a Bureau of Land Management funded survey designed to synthesize paleontologic information into a geographic information system (GIS) as a distributable geodatabase. The database is designed to represent surficial geologic deposits contained in a polygon shapefile. Throughout the State of Nevada each polygon represents a mapped geologic unit at a scale of at least 1:250 k. Each mapped geologic unit is then assigned a “potential fossil yield classification”, a numerical ranking value of 1-5 based …

Assessing Minimal-Input Restoration Strategies For Desert Soil And Vegetation Restoration, Audrey Jean Rader

UNLV Theses, Dissertations, Professional Papers, and Capstones

The Mojave and Sonoran Deserts have been negatively impacted by anthropogenic disturbances. Considering that these ecosystems may recover on millennial timescales, research has shown that restoration techniques can be fairly successful in initiating long-term recovery processes in these sensitive environments. However, uncertainty remains as to which techniques are effective in different circumstances, such as in different climates or across different soil properties, and which techniques may best avoid unintended consequences, such as facilitating non-native plants. To reduce fugitive dust as a human health hazard, increase soil stability, and enhance wildlife habitat, further work is necessary to develop restoration techniques for …

Riding My Bike In Paradise With Margaret Fuller: A Phenomenological Study, Nanette Rasband Hilton

UNLV Theses, Dissertations, Professional Papers, and Capstones

Margaret Fuller (1810-1850) was perhaps the most famous American woman during the nineteenth century. After her tragic death, reprints of her best-selling books were heavily edited and she was nearly forgotten. During and after her lifetime, Fuller fell victim to the phenomenological alterity identified and defined by theorists including Derrida and Edward Said as Othering. She spent her career combating Othering in all its forms. Through the lens of both social identity theory and multiple identity theory this study examines how Fuller grappled with social prescriptions. As an autodidact, she mined diverse literary resources to construct heterogeneous texts that cultivate …

Long-Term Monitoring Of Rare Gypsum Communities In The Eastern Mojave Desert: A Study In Science And Art, Tiffany Jane-Marie Pereira

UNLV Theses, Dissertations, Professional Papers, and Capstones

For land managers, reliable estimates of soil seed banks, and more specifically, change in seed banks over time, provide insight into the restoration and regeneration potential of the landscape, site history and disturbance mapping, and, invasive and rare plant management. To understand the intricacies of desert soil seed banks in relation to aboveground vegetation change, my research evaluated long-term change in soil seed banks, fertile islands, and plant communities of conservation-priority gypsum rare plant habitat of the eastern Mojave Desert. Research found significant spatial and temporal differences in seed bank composition and density over an 11-year period; however, the gypsum …

Benchmarking Permutation Flow Shop Problem: Adaptive And Enumerative Approaches Implementations Via Novel Threading Techniques, Hari Prasad Sapkota

UNLV Theses, Dissertations, Professional Papers, and Capstones

A large number of real-world planning problems are combinatorial optimization problems which are easy to state and have a finite but usually very large number of feasible solutions. The minimum spanning tree problem and the shortest path problem are some which are solvable through polynomial algorithms. Even though there are other problems such as crew scheduling, vehicle routing, production planning, and hotel room operations which have no properties such as to solve the problem with polynomial algorithms. All these problems are NP-hard. The permutation flow shop problem is also NP-hard problem and they require high computation. These problems are solvable …

Cesium Platinum Iodide Perovskite Synthesis, Development And Application In Photovoltaic Devices, Dakota Schwartz

UNLV Theses, Dissertations, Professional Papers, and Capstones

Third generation photovoltaics, including perovskites, are essential to improving solar technology for widespread future use. Perovskite solar cells have surpassed 23.7% power conversion efficiency, comparable to traditional silicon photovoltaic panels. However, these perovskites are fabricated using lead-based compounds, posing toxicity issues. Furthermore, existing perovskites have limited thermal and moisture stability in ambient environments. In order to address toxicity and stability concerns, as well as to maximize photon absorption in solar cells through bandgap optimization, this effort focuses on the development of novel leadfree perovskite materials. A cesium platinum iodide composition is selected as a model system due to the theoretical …

Rethinking Timestamping: Time Stamp Counter Design For Virtualized Environment, Alexander Tabatadze

UNLV Theses, Dissertations, Professional Papers, and Capstones

Almost every processor supports Time Stamp Counter (TSC), which is a hardware register that increments its value every clock cycle. Due to its high resolution and accessibility, TSC is now widely used for a variety tasks that need time measurements such as wall clock, code benchmarking, or metering hardware usage for account billing.

However, if not carefully configured and interpreted, TSC-based time measurements can yield inaccurate readings. For instance, modern CPU may dynamically change its frequency or enter into low-power states. Also, time spent on scheduling events, system calls, page faults, etc. should be correctly accounted for. Even more complications …

Generating Kernel Aware Polygons, Bibek Subedi

UNLV Theses, Dissertations, Professional Papers, and Capstones

Problems dealing with the generation of random polygons has important applications for evaluating the performance of algorithms on polygonal domain. We review existing algorithms for generating random polygons. We present an algorithm for generating polygons admitting visibility properties. In particular, we propose an algorithm for generating polygons admitting large size kernels. We also present experimental results on generating such polygons.

Effects Of Disturbance And Restoration Treatment On Fertile Islands In Lake Mead National Recreation Area, Camille Traylor

UNLV Theses, Dissertations, Professional Papers, and Capstones

Disturbances by humans are one of the main drivers of change in contemporary desert ecosystems. Restoration treatments such as topsoil application and outplanting can be implemented in response to disturbances in order to maintain soil stability and a diverse plant community. Fertile islands - nutrient enriched areas beneath perennial shrubs - are fundamental features of deserts that can facilitate annual plant growth. A major uncertainty in desert ecology is how much time is required for fertile islands and nurse plant effects (the facilitation of one plant by another) to develop below maturing perennial plants. By studying naturally recruited perennial plants …