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University of Nebraska Medical Center

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Robotic Assisted Bronchoscopy: An Institutional Correlation Between Cytopathology And Surgical Resection Diagnoses, Thomas Auen Jun 2024

Robotic Assisted Bronchoscopy: An Institutional Correlation Between Cytopathology And Surgical Resection Diagnoses, Thomas Auen

Graduate Medical Education Research Journal

NA


Systemic Sclerosis Masquerading As Superior Mesenteric Artery Syndrome, Alexandra Fiedler Jun 2024

Systemic Sclerosis Masquerading As Superior Mesenteric Artery Syndrome, Alexandra Fiedler

Graduate Medical Education Research Journal

NA


A Paralyzing Consequence: Succinylcholine-Induced Hyperkalemia, A Rare But Dangerous Side Effect, Hannah Kruger Jun 2024

A Paralyzing Consequence: Succinylcholine-Induced Hyperkalemia, A Rare But Dangerous Side Effect, Hannah Kruger

Graduate Medical Education Research Journal

NA


Between The Aorta And Superior Mesenteric Artery: A Tale Of Duodenal Compression, Alexandra Fiedler Jun 2024

Between The Aorta And Superior Mesenteric Artery: A Tale Of Duodenal Compression, Alexandra Fiedler

Graduate Medical Education Research Journal

NA


Needs Assessment Of Internal Medicine Learners In Hospital Medicine Competencies, Matthew Kretschmar Jun 2024

Needs Assessment Of Internal Medicine Learners In Hospital Medicine Competencies, Matthew Kretschmar

Graduate Medical Education Research Journal

NA


Outcome Of Organ Procurement And Transplantation Network Policy Allowing For Waiting Time Modification For Candidates Affected By Race-Inclusive Egfr Calculations, Debra Wekesa Jun 2024

Outcome Of Organ Procurement And Transplantation Network Policy Allowing For Waiting Time Modification For Candidates Affected By Race-Inclusive Egfr Calculations, Debra Wekesa

Graduate Medical Education Research Journal

NA


Report Study – A Comparison Of Self-Reported Alcohol Intake Compared To Phosphatidylethanol Value As A Predictor For Return To Alcohol Use, Kevin Brittan Jun 2024

Report Study – A Comparison Of Self-Reported Alcohol Intake Compared To Phosphatidylethanol Value As A Predictor For Return To Alcohol Use, Kevin Brittan

Graduate Medical Education Research Journal

NA


Prosthetic Valve Endocarditis With Cardiobacterium Hominis: A Case Report, Kaci Griffin Jun 2024

Prosthetic Valve Endocarditis With Cardiobacterium Hominis: A Case Report, Kaci Griffin

Graduate Medical Education Research Journal

NA


Establishing The Problem: Identifying Barriers To Workflow Among Internal Medicine Resident Physicians Within The Va Medical Center, Joshua Warner Jun 2024

Establishing The Problem: Identifying Barriers To Workflow Among Internal Medicine Resident Physicians Within The Va Medical Center, Joshua Warner

Graduate Medical Education Research Journal

NA


Vitamin D Deficiency In Patients With Symptoms Of Depression, Anyun Ma Jun 2024

Vitamin D Deficiency In Patients With Symptoms Of Depression, Anyun Ma

Graduate Medical Education Research Journal

NA


Risk Of Coronary Artery Calcification Due To Sarcopenia: A Meta-Analysis, Advait Vasavada Jun 2024

Risk Of Coronary Artery Calcification Due To Sarcopenia: A Meta-Analysis, Advait Vasavada

Graduate Medical Education Research Journal

NA


Paternity Matters: Does Paternal Involvement Have An Effect On Prenatal Care?, Jacob Vasa Jun 2024

Paternity Matters: Does Paternal Involvement Have An Effect On Prenatal Care?, Jacob Vasa

Graduate Medical Education Research Journal

NA


Effect Of Advanced Patient Scheduling On Patient- And Resident-Continuity, Michael Schulte Jun 2024

Effect Of Advanced Patient Scheduling On Patient- And Resident-Continuity, Michael Schulte

Graduate Medical Education Research Journal

NA


Ai For A Eye: Implementing Point-Of-Care Artificial Intelligence Retinal Screening In A Resident Clinic, Cody Masters Jun 2024

Ai For A Eye: Implementing Point-Of-Care Artificial Intelligence Retinal Screening In A Resident Clinic, Cody Masters

Graduate Medical Education Research Journal

NA


Lead Me To Lead Screening: Improving Lead Screening Rates At Urban, High-Risk Family Medicine Clinic, Taylor Defreece Jun 2024

Lead Me To Lead Screening: Improving Lead Screening Rates At Urban, High-Risk Family Medicine Clinic, Taylor Defreece

Graduate Medical Education Research Journal

NA


A Race Against Time: The Importance Of Early Surgical Intervention In Patients With Mycotic Aortic Aneurysms, Chydubem Nwaiwu Jun 2024

A Race Against Time: The Importance Of Early Surgical Intervention In Patients With Mycotic Aortic Aneurysms, Chydubem Nwaiwu

Graduate Medical Education Research Journal

NA


Parasite Sufficiency Anemia – A Mysterious Cause Of Iron Deficiency Anemia, Garima Bhandari Jun 2024

Parasite Sufficiency Anemia – A Mysterious Cause Of Iron Deficiency Anemia, Garima Bhandari

Graduate Medical Education Research Journal

NA


Jedi With Jasmine: Developing And Assessing A Gme Curriculum On Justice, Equity, Diversity, And Inclusion, Sandra Frimpong Jun 2024

Jedi With Jasmine: Developing And Assessing A Gme Curriculum On Justice, Equity, Diversity, And Inclusion, Sandra Frimpong

Graduate Medical Education Research Journal

NA


A Case Of Radiation Recall Dermatitis From Zanubrutinib, Taylor Thieman Jun 2024

A Case Of Radiation Recall Dermatitis From Zanubrutinib, Taylor Thieman

Graduate Medical Education Research Journal

NA


Iron Deficiency Anemia In Children With Short Bowel Syndrome, Rasheedat Yetunde Fawole Jun 2024

Iron Deficiency Anemia In Children With Short Bowel Syndrome, Rasheedat Yetunde Fawole

Graduate Medical Education Research Journal

NA


Assessing The Accuracy Of Weights With Stretcher Scales: A Novel Approach To Patient Safety, Elizabeth Reiche Jun 2024

Assessing The Accuracy Of Weights With Stretcher Scales: A Novel Approach To Patient Safety, Elizabeth Reiche

Graduate Medical Education Research Journal

NA


Implementation Of An Algorithm To Reduce Wait Times For College-Aged Women Presenting With Uti Symptoms, Mallory Beck, Miranda Neu May 2024

Implementation Of An Algorithm To Reduce Wait Times For College-Aged Women Presenting With Uti Symptoms, Mallory Beck, Miranda Neu

Doctor of Nursing Practice Projects: College of Nursing

Urinary tract infections, UTIs, are among the most common reasons college-aged women seek medical care. The selected University clinic has a difficult time triaging walk-in UTI patients promptly. Long patient wait times have a negative effect on patient and employee satisfaction scores. An algorithm was created to assist the University clinic in triaging walk-in UTI patients using guidelines from the American Academy of Family Physicians updated with the most current clinical practice recommendations. The algorithm includes the utilization of a point-of-care urine analyzer which provides urinalysis results in 120 seconds. With the algorithm and point-of-care urine analyzer, the student health …


The Physiological Significance Of Nitric Oxide Synthase In Staphylococci, Ryan M. Singh May 2024

The Physiological Significance Of Nitric Oxide Synthase In Staphylococci, Ryan M. Singh

Theses & Dissertations

Staphylococci, particularly Staphylococcus epidermidis, are common causes of implant-associated infections that may result in notable morbidity and mortality. One of the ways the innate immune system attempts to combat these invading pathogens is via the respiratory burst, in which free radical species such as nitric oxide (NO•), toxic to bacterial respiration, are released in large quantities. Despite the toxicity of NO•, some bacteria, including staphylococci, encode an endogenous bacterial nitric oxide synthase (bNOS), whose physiological role has been unclear until now. In this dissertation, we demonstrate that S. epidermidis is able to overcome the toxicity …


Impact Of Nutritional Status And Placental Malaria Infection On Pregnancy Outcome In A Population Of Nigerian Maternal-Infant Dyads, Shirley F. Delair May 2024

Impact Of Nutritional Status And Placental Malaria Infection On Pregnancy Outcome In A Population Of Nigerian Maternal-Infant Dyads, Shirley F. Delair

Theses & Dissertations

Nigeria is the most populous country in Africa and accounts for one-quarter of the newborn mortality on the continent. Most newborn deaths are from prematurity (33%), infections (33%), and intrapartum complications (31%). Using an adapted analytical framework for the study of child survival in developing countries, this dissertation aimed to look at the pregnancy outcome of a population of Nigerian women and their offspring by looking at proximate determinants of health from nutritional status and environmental conditions. In Chapter 1, we characterized the micronutrients of the mother-infant dyads, looking specifically at concentrations of vitamin D and its metabolites. In Chapter …


Bridging The Information Divide: Leveraging The Learning Health System To Understand Rural-Urban Health Disparities In The Covid-19 Era, Alfred J. Anzalone May 2024

Bridging The Information Divide: Leveraging The Learning Health System To Understand Rural-Urban Health Disparities In The Covid-19 Era, Alfred J. Anzalone

Theses & Dissertations

The examination of healthcare disparities, which the COVID-19 pandemic exacerbated, revealed a pronounced divide between rural and urban settings. This divide particularly underscored the challenges of integrating rural healthcare into the Learning Health System (LHS) and utilizing real-world data (RWD) in response to a public health emergency. Our investigation expanded the growing body of literature on the rural mortality penalty, encompassing the period following the COVID-19 pandemic. By employing an LHS-enabled centralized platform of RWD, we assessed the impact of rurality on adverse COVID-19 outcomes (Aim 1), focusing on inpatient adverse events and the effectiveness of treatments and vaccinations across …


Development Of Long-Acting Antiviral And Antimicrobial Prodrug Nanoformulations, Srijanee Das May 2024

Development Of Long-Acting Antiviral And Antimicrobial Prodrug Nanoformulations, Srijanee Das

Theses & Dissertations

Over the past decade, the global burden of infectious diseases has increased substantively, underscoring the need for more effective treatment strategies. However, the discovery and development of new drugs with desirable safety, pharmacokinetics, and efficacy is a time consuming and costly process with great uncertainty around success rate. As an alternative to new drug development, prodrugs and novel drug delivery systems have increasingly been explored. Both serve to overcome the drug development challenges. Such drug formulations that permit extended dosing intervals of potent native drugs serve multiple purposes by promoting patient adherence to in improving treatment outcomes. This is especially …


A Tale Of Two Proteins: An Investigation Of Recruitment Of Eukaryotic Proteins Fli1 And Lrrf1 To The Chlamydial Inclusion Membrane, Natalie Sturd May 2024

A Tale Of Two Proteins: An Investigation Of Recruitment Of Eukaryotic Proteins Fli1 And Lrrf1 To The Chlamydial Inclusion Membrane, Natalie Sturd

Theses & Dissertations

Chlamydia trachomatis is the pathogen responsible for the majority of infectious blindness and sexually transmitted bacterial infections worldwide. As an obligate intracellular pathogen, it establishes a niche within a pathogen-specific vacuole, termed the chlamydial inclusion. C. trachomatis modifies the inclusion membrane by type III secretion and insertion of effectors known as inclusion membrane proteins, or Incs. These Inc proteins are critical for chlamydial pathogenesis via their interactions with host proteins and their capacity to stabilize the inclusion membrane. Previous studies from our lab demonstrated the localization of two eukaryotic proteins, Flightless 1 (FLI1) and its binding partner leucine-rich repeat interacting …


Mucins: Drivers Of Cancer Cell And Microenvironment Crosstalk In Pancreatic Cancer, Xiaoqi Li May 2024

Mucins: Drivers Of Cancer Cell And Microenvironment Crosstalk In Pancreatic Cancer, Xiaoqi Li

Theses & Dissertations

Mucins facilitate the pancreatic cancer (PC) initiation, progression, and metastasis. Among mucins, MUC4 has been reported to inhibit lymphokine-activated cell killing and induce the apoptosis of cytotoxic T-cells. Counterintuitively, MUC4 expression is upregulated by multiple T-cell-secreted cytokines, such as IFN-γ, IL-17, and stroma-secreted factors like retinoic acid. Previously, we have identified that nuclear receptor coactivator 3 (NCOA3) regulates the MUC1 and MUC4 expression by increasing chromatin accessibility and maintaining protein stability. However, the comprehensive crosstalk mediated by MUC4 in cancer cells and T-cells and how its upstream regulator, NCOA3, modifies the cancer cell-intrinsic behavior is still elusive. Here, we show …


Therapeutic Effects Of Bet Protein Inhibition In B-Cell Malignancies And Beyond, Audrey L. Smith May 2024

Therapeutic Effects Of Bet Protein Inhibition In B-Cell Malignancies And Beyond, Audrey L. Smith

Theses & Dissertations

Chronic lymphocytic leukemia (CLL) develops through a combination of intrinsic genetic defects, constitutively active survival/proliferation signaling pathways, and complex microenvironment interactions. Redundant tumor microenvironment (TME) immuno-suppressive mechanisms and epigenetic maintenance of terminal T-cell dysfunction also greatly hinder anti-tumor T-cell responses in CLL. Small-molecule agents targeting the B-cell receptor (BCR) pathway and anti-apoptotic proteins alone or in combination with chemo-immunotherapy have revolutionized the management of CLL, yet there is still a significant need for novel therapeutic strategies to yield durable tumor elimination. Bromodomain and extra-terminal domain (BET) proteins are epigenetic readers that bind to acetyl-lysine residues on histones to regulate gene …


Genetic Drivers And Tumor Milieu Analysis In Mantle Cell Lymphoma, Sunandini Sharma May 2024

Genetic Drivers And Tumor Milieu Analysis In Mantle Cell Lymphoma, Sunandini Sharma

Theses & Dissertations

Mantle Cell Lymphoma (MCL) is a B-cell lymphoma characterized by t(11;14) leading to CyclinD1 (CCND1) overexpression with highly variable clinical response. Although the tumor intrinsic mechanisms have been fairly studied, the role of the tumor microenvironment (TME) in survival and therapeutic responses is marginally examined. Herein, we integrated high-throughput genomics and characterized TME using a highly multiplexed, spatially resolved, single-cell digital pathology approach termed imaging mass cytometry (IMC) to delineate the tumor-immune landscape. We identified eight MCL genomic subtypes with distinct signatures and prognoses. Subsets C2, C5, and C6 had poorer outcomes with a 5-year overall survival (OS) of 33-50% …