Digital Commons Network^™

Stronger Together: Building Nonprofit Resilience Through A Network With A Shared Mission And Organizational Humility, Haley M. Woznyj, Oscar J. Stewart, Tammy E. Beck

Department of Management: Faculty Publications

Nonprofit organizations increasingly face surprising and disruptive shocks, beyond financial setbacks, that challenge an organization's operations, long-term survival, and success. To continue to execute their mission, nonprofits must be resilient. Despite the importance of resilience in nonprofits, more research is needed to understand the factors that build organizational resilience and how leaders can help promote resilience. We conducted a qualitative case study, consisting of 23 interviews with organizational members and key partners, fieldwork, and archival information, of a documented resilient nonprofit organization. Our findings suggest that leaders can enhance resilience by gaining access to resources through collaboration, which is in …

An Evolutionary Pathway For Coping With Emerging Infectious Disease, Scott Lyell Gardner, Daniel R. Brooks, Walter A. Boeger, Eric P. Hoberg

Zea E-Books Collection

Emerging infectious disease (EID) represents an existential threat to humanity. EIDs are increasing in frequency and impact because of climate change and other human activities. We are losing the battle against EIDs because of improper assessment of the risk of EID. This stems from adherence to a failed paradigm of pathogen-host associations that suggests EIDs ought to be both unpredictable and rare. That, in turn, leads to policies suggesting that crisis response is the best we can do. Real-time and phylogenetic assessments show EIDs to be neither rare nor unpredictable—this is the parasite paradox that shows the failures of the …

Presence, Co-Occurrence, And Daily Intake Estimates Of Aflatoxins And Fumonisins In Maize Consumed In Food-Insecure Regions Of Western Honduras, Luis Sabillón, Jackeline Alvarado, Alejandra Leiva, Rodrigo Mendoza, Raúl Espinal, John F. Leslie, Andreia Bianchini

Department of Food Science and Technology: Faculty Publications

Foodborne mycotoxins are a significant food safety risk in developing countries. Our objective was to determine the occurrence of and exposure levels to aflatoxins (AFs) and fumonisins (FBs) in maize intended for human and animal consumption in food-insecure regions of western Honduras. Total AFs and FBs were quantified with a monoclonal antibody-based affinity spectrofluorimetric method. FBs were detected in 614/631 samples of maize destined for human consumption at 0.3 to 41 mg/kg (mean, 2.7 mg/kg). Of the 614 positive samples, 147 had FB levels exceeding the U.S. Food and Drug Administration (FDA) advisory threshold of 4.0 mg/kg. AFs were detected …

Strengthening Brain Research In Africa, Abdullahi Tunde Aborode, Nike Jesutofunmi Idowu, Samuel Tundealao, Joseph Jaiyeola, Ogunware Adedayo Emmanuel

Department of Chemistry: Faculty Publications

This paper explores the emerging field of neuroscience in Africa, considering the unique genetic diversity, sociocultural determinants, and health inequalities in the continent. It presents numerous brain research initiatives, such as ABDRN, AMARI, APCDR, and H3Africa, aimed at understanding genetic and environmental factors influencing brain disorders in Africa. Despite numerous challenges like the brain drain phenomenon, inadequate infrastructure, and scarce research expertise, significant progress has been achieved. The paper proposes solutions, including international collaboration, capacity-building efforts, and policies to promote neuroscience research, to enhance the understanding of brain function and address brain-related health issues within the African context.

Daily Injection Of The Β2 Adrenergic Agonist Clenbuterol Improved Poor Muscle Growth And Body Composition In Lambs Following Heat Stress-Induced Intrauterine Growth Restriction, Rachel L. Gibbs, Rebecca M. Swanson, Joslyn K. Beard, Zena M. Hicks, Micah S. Most, Haley Beer, Pablo C. Grijalva, Shawna M. Clement, Eileen Marks-Nelson, Ty B. Schmidt, Jessica Lynn Petersen, Dustin T. Yates

Department of Animal Science: Faculty Publications

Background: Intrauterine growth restriction (IUGR) is associated with reduced β2 adrenergic sensitivity, which contributes to poor postnatal muscle growth. The objective of this study was to determine if stimulating β2 adrenergic activity postnatal would rescue deficits in muscle growth, body composition, and indicators of metabolic homeostasis in IUGR offspring.

Methods: Time-mated ewes were housed at 40°C from day 40 to 95 of gestation to produce IUGR lambs. From birth, IUGR lambs received daily IM injections of 0.8 μg/kg clenbuterol HCl (IUGR+CLEN; n = 11) or saline placebo (IUGR; n = …

Enhancing The Assessment Of Coercive Control In Spanish Femicide Cases: A Nationally Representative Qualitative Analysis, Rosa Viñas‑Racionero, Chitra Raghavan, Miguel Ángel Soria‑Verde, Mario J. Scalora, Jorge Santos‑Hermoso, José Luís González‑Álvarez, María José Garrido‑Antón

Department of Psychology: Faculty Publications

Purpose Coercive control is a power dynamic central to intimate partner violence (IPV) and consists of tactics to limit one’s partner’s autonomy through constraint, regulation of everyday life, isolation, pursuit, and intimidation and physical force. Such tactics may potentially signal a risk for future lethal or near lethal violence; hence, proper evaluation may enhance the utility of clinical femicide risk assessments. The goal of this study is to explore coercive control behaviors preceding partner femicides in Spain with the intention to provide guidance for its assessment by first responders and law enforcement.

Methods Researchers from the Department of State for …

Negative Interpretation Bias Connects To Real-World Daily Affect: A Multistudy Approach, Nikki A. Puccetti, William J. Villano, Caitlin A. Stamatis, Kimberly Arditte Hall, Vilet F. Torrez, Maital Neta, Kiara R. Timpano, Aaron S. Heller

Department of Psychology: Faculty Publications

Negative interpretation bias, the tendency to appraise ambiguous stimuli as threatening, shapes our emotional lives. Various laboratory tasks, which differ in stimuli features and task procedures, can quantify negative interpretation bias. However, it is unknown whether these tasks globally predict individual differences in real-world negative (NA) and positive (PA) affect. Across two studies, we tested whether different lab-based negative interpretation bias tasks predict daily NA and PA, measured via mobile phone across months. To quantify negative interpretation bias, Study 1 (N = 69) used a verbal, self-referential task whereas Study 2 (N = 110) used a perceptual, emotional …

Energy Dissipation Optimization For Circular Culverts, David M. Admiraal, Chi Zhang

Nebraska Department of Transportation: Research Reports

Two types of energy dissipation devices at circular culvert outlets were investigated: full-length weirs and staggered weirs. Related literature was reviewed; a model broken-back circular culvert and dissipation basin was built; instrumentation was installed to measure discharge, piezometric head, and velocities; and four sizes of full-length and staggered weirs were tested over a range of discharges and tailwaters. Weir heights ranged from D/8 to 4D/8, in which D was the culvert diameter. The two weir types were subjected to two styles of tests: (1) tests unaffected by tailwater and (2) tailwater-influenced tests. For tall full-length weirs (3D/8 and 4D/8), basin …

Ferromagnetic Resonators Synthesized By Metal-Organic Decomposition Epitaxy, Nhat Nguyen, Bryce Herrington, Kayetan Chorazewicz, Szu-Fan (Paul) Wang, Ruthi Zielinski, John Turner, Paul D. Ashby, Ufuk Kilic, Eva Schubert, Mathias Schubert, Ronald A. Parrott, Allen A. Sweet, Robert Streubel

Department of Physics and Astronomy: Faculty Publications

Metal-organic decomposition epitaxy is an economical wet-chemical approach suitable to synthesize high-quality low-spin-damping films for resonator and oscillator applications. This work reports the temperature dependence of ferromagnetic resonances and associated structural and magnetic quantities of yttrium iron garnet nanofilms that coincide with single-crystal values. Despite imperfections originating from wet-chemical deposition and spin coating, the quality factor for out-of-plane and in-plane resonances approaches 600 and 1000, respectively, at room temperature and 40 GHz. These values increase with temperature and are 100 times larger than those offered by commercial devices based on complementary metal-oxide semiconductor voltage-controlled oscillators at comparable production costs.

Is Climate Change Causing The Range Contraction Of Cape Rock-Jumpers (Chaetops Frenatus)?, Gregory D. Duckworth, Raquel A. Garcia, Rheinhardt Scholtz, Res Altwegg

Department of Agronomy and Horticulture: Faculty Publications

Species distribution models often suggest strong links between climate and species' distribution boundaries and project large distribution shifts in response to climate change. However, attributing distribution shifts to climate change requires more than correlative models. One idea is to examine correlates of the processes that cause distribution shifts, namely colonization and local extinction, by using dynamic occupancy models. The Cape Rock-jumper (Chaetops frenatus) has disappeared over most of its distribution where temperatures are the highest. We used dynamic occupancy models to analyse Cape Rock-jumper distribution with respect to climate (mean temperature and precipitation over the warmest annual quarter), …

Think Again: The Role Of Reappraisal In Reducing Negative Valence Bias, Maital Neta, Nicholas R. Harp, Tien T. Tong, Claudia J. Clinchard, Catherine C. Brown, James J. Gross, Andero Uusberg

Department of Psychology: Faculty Publications

Stimuli such as surprised faces are ambiguous in that they are associated with both positive and negative outcomes. Interestingly, people differ reliably in whether they evaluate these and other ambiguous stimuli as positive or negative, and we have argued that a positive evaluation relies in part on a biasing of the appraisal processes via reappraisal. To further test this idea, we conducted two studies to evaluate whether increasing the cognitive accessibility of reappraisal through a brief emotion regulation task would lead to an increase in positive evaluations of ambiguity. Supporting this prediction, we demonstrated that cuing reappraisal, but not in …

Identifying Early-Life Behavior To Predict Mothering Ability In Swine Utilizing NuTrack System, Savannah Millburn, Ty B. Schmidt, Gary A. Rohrer, Benny Mote

Department of Animal Science: Faculty Publications

Early indicator traits for swine reproduction and longevity support economical selection decision-making. Activity is a key variable impacting a sow’s herd life and productivity. Early-life activities could contribute to farrowing traits including gestation length (GL), number born alive (NBA), and number weaned (NW). Beginning at 20 weeks of age, 480 gilts were video recorded for 7 consecutive days and processed using the NUtrack system. Activity traits included angle rotated (radians), average speed (m/s), distance traveled (m), time spent eating (s), lying lateral (s), lying sternal (s), standing (s), and sitting (s). Final daily activity values were averaged across the …

Integrating Glycolysis, Citric Acid Cycle, Pentose Phosphate Pathway, And Fatty Acid Beta‑Oxidation Into A Single Computational Model, Sylwester M. Kloska, Krzysztof Pałczyński, Tomasz Marciniak, Tomasz Talaśka, Beata J. Wysocki, Paul H. Davis, Tadeusz A. Wysocki

Department of Electrical and Computer Engineering: Faculty Publications

The metabolic network of a living cell is highly intricate and involves complex interactions between various pathways. In this study, we propose a computational model that integrates glycolysis, the pentose phosphate pathway (PPP), the fatty acids beta-oxidation, and the tricarboxylic acid cycle (TCA cycle) using queueing theory. The model utilizes literature data on metabolite concentrations and enzyme kinetic constants to calculate the probabilities of individual reactions occurring on a microscopic scale, which can be viewed as the reaction rates on a macroscopic scale. However, it should be noted that the model has some limitations, including not accounting for all the …

Contextual Determinants Of Re-Reporting For Families Receiving Alternative Response: A Survival Analysis In A Midwestern State, Jianchao Lai, Michelle Graef, Todd Franke, Toby Burnham

Center on Children, Families, and the Law: Faculty Publications

Differential response (DR) has been widely adopted in over 30 states to address shortcomings of the traditional approach to child maltreatment reports in complex family and case circumstances. However, despite continued evaluation efforts, evidence of the effectiveness of DR remains inconclusive. The current study aims to assess the impact of a DR program and potential predictors, including service match and number of family case workers, on maltreatment re-reports in a Midwestern state. The study utilized a randomized control trial and assigned eligible families to either the Alternative Response (AR) track or Traditional Response (TR) track. The enrollment was implemented in …

The Casnr L.I.N.K.S. Newsletter: Learning Innovation Network For K-12 Schools, Volume 2, Edition 8, Septembery 2023, Bailey Feit, Tammy Mittelstet

CASNR L.I.N.K.S. Newsletter

The purpose of this L.I.N.K.S. newsletter is to provide a monthly update of opportunities and resources for K-12 schools to connect with the University of Nebraska's CASNR Food, Energy, Water, and Societal Systems (FEWS²) programs and partners.

Included in this edition:

Upcoming events, 2023-2024

October 7-Experience the Power of Red Visit Day; Nov. 8-Panhandle REEC Career Day-Scottsbluff; March 21-NJAS Southeast Regional Science Fair; March 25-Eastern Nebraska World Food Prize; March 28-Northeast Education Compact School Visit Day; April 10- Cultivando Caminos (cultivating Pathways) conference; April 15-Western Nebraska World Food Prize-Scottsbluff; April 18-NJAS State Science Fair

University of Nebraska State Museum Morrill …

Neurodiversity And The Legal Profession, Kala Mueller, Stefanie S. Pearlman

Nebraska College of Law: Faculty Publications

This article discusses ways to make the legal profession in Nebraska more accessible and inclusive for neurodivergent attorneys, beginning in law school and continuing through licensing, and hiring practices.

Perceptions Of Well-Being And The Economy In Nonmetropolitan Nebraska, Rebecca J. Vogt, Heather Akin, Cheryl A. Burkhart-Kriesel, Bradley D. Lubben, L. J. Mcelravy, Timothy Meyer, Steven A. Schulz

Nebraska Rural Poll

This year, rural Nebraskans are more pessimistic about their current situation than they’ve been in the past ten years. The proportion believing they are worse off than they were five years ago was 27 percent, up from the 21 percent last year and 11 percent in 2021. This is the highest level since both 2003 and 2009, when 28 percent believed they were worse off. This increase in pessimism was matched with a decrease in optimism. This year, less than onehalf (45%) of rural Nebraskans believe they are better off compared to five years ago, down from 50 percent last …

Antibiotic-Induced Gut Dysbiosis And Cognitive, Emotional, And Behavioral Changes In Rodents: A Systematic Review And Meta-Analysis, Shivdeep S. Hayer, Soonjo Hwang, Jonathan B. Clayton

Food for Health: Publications

There are previous epidemiological studies reporting associations between antibiotic use and psychiatric symptoms. Antibiotic-induced gut dysbiosis and alteration of microbiota-gut-brain axis communication has been proposed to play a role in this association. In this systematic review and meta-analysis, we reviewed published articles that have presented results on changes in cognition, emotion, and behavior in rodents (rats and mice) after antibiotic-induced gut dysbiosis. We searched three databases—PubMed, Web of Science, and SCOPUS to identify such articles using dedicated search strings and extracted data from 48 articles. Increase in anxiety and depression-like behavior was reported in 32.7 and 40.7 percent of the …

Antibiotic-Induced Gut Dysbiosis And Cognitive, Emotional, And Behavioral Changes In Rodents: A Systematic Review And Meta-Analysis, Shivdeep S. Hayer, Soonjo Hwang, Jonathan B. Clayton

Food for Health: Publications

There are previous epidemiological studies reporting associations between antibiotic use and psychiatric symptoms. Antibiotic-induced gut dysbiosis and alteration of microbiota-gut-brain axis communication has been proposed to play a role in this association. In this systematic review and meta-analysis, we reviewed published articles that have presented results on changes in cognition, emotion, and behavior in rodents (rats and mice) after antibiotic-induced gut dysbiosis. We searched three databases—PubMed, Web of Science, and SCOPUS to identify such articles using dedicated search strings and extracted data from 48 articles. Increase in anxiety and depression-like behavior was reported in 32.7 and 40.7 percent of the …

How Is Flash Drought Understood?—Experts’ Definitions And Decision-Makers’ Perceptions, Caily Schwartz, Tonya Haigh, Mark D. Svoboda, Madeline Goebel

National Drought Mitigation Center: Faculty Publications

Because flash drought is a relatively new phenomenon in drought research, defining the concept is critical for scientists and decision-makers. Having detrimental impacts on many sectors, it is important to have a consistent definition and understanding of flash drought, between experts and stakeholders, to provide early warning to the community. This study focuses on onset and progression of conditions and demonstrates the difference in flash drought identification for 15 events across six quantitative definitions of flash drought that use the U.S. Drought Monitor (USDM). Five flash drought events have been studied in the literature while 10 additional events have been …

Dousing The Flame: Reviewing The Mechanisms Of Inflammatory Programming During Stress-Induced Intrauterine Growth Restriction And The Potential For Ω-3 Polyunsaturated Fatty Acid Intervention, Melanie White, Dustin T. Yates

Department of Animal Science: Faculty Publications

Intrauterine growth restriction (IUGR) arises when maternal stressors coincide with peak placental development, leading to placental insufficiency. When the expanding nutrient demands of the growing fetus subsequently exceed the capacity of the stunted placenta, fetal hypoxemia and hypoglycemia result. Poor fetal nutrient status stimulates greater release of inflammatory cytokines and catecholamines, which in turn lead to thrifty growth and metabolic programming that benefits fetal survival but is maladaptive after birth. Specifically, some IUGR fetal tissues develop enriched expression of inflammatory cytokine receptors and other signaling cascade components, which increases inflammatory sensitivity even when circulating inflammatory cytokines are no longer elevated …

Protective Factors In The Relationship Between Perceived Discrimination And Risky Drinking Among American Indian Adolescent, Ying Guo, Randall C. Swaim, W. Alex Mason

Department of Child, Youth, and Family Studies: Faculty Publications

Introduction: The relationship between perceived discrimination and risky drinking among American Indian (AI) youth is understudied, and the potential protective factors that may buffer this association are unknown. Therefore, the objective of this study was to examine protective factors across individual, family, school, peer, and cultural domains of the social ecology that might attenuate the relationship between perceived discrimination and risky drinking among AI adolescents.

Method: Data were from the Substance Use Among American Indian Youth Study (Swaim and Stanley, 2018, 2021). AI youth who have used alcohol in their lifetime (n = 2516 within 62 schools) …

Experiences Of Professionals Of Color In The Child Welfare Workforce, Nina Williams-Mbengue, Anita Barbee

Other QIC-WD Products

“Entrenched disparities in our laws and public policies, and in our public and private institutions, have often denied that equal opportunity to individuals and communities. Our country faces converging economic, health, and climate crises that have exposed and exacerbated inequities, while a historic movement for justice has highlighted the unbearable human costs of systemic racism.”

- Executive Order on Advancing Racial Equity and Support for Underserved Communities through the Federal Government, January 20, 2021

Many Americans are currently engaged in a painful examination of the nation’s history of individual, interpersonal, institutional, and structural racism. Leaders within the child welfare system …

United States Department Of Education Response To The Office Of Science And Technology Policy Memo, 2022: Public Access Plan (September 2023)

Copyright, Fair Use, Scholarly Communication, etc.

DoED response to OSTP memo, 2022: Public Access Plan (September 2023)

Shallow-Water Hydrothermal Venting Linked To The Palaeocene–Eocene Thermal Maximum, Christian Berndt, Sverre Planke, Carlos A. Alvarez Zarikian, Joost Frieling, Morgan T. Jones, John M. Millett, Henk Brinkhuis, Stefan Bünz, Henrik H. Svensen, Jack Longman, Reed P. Scherer, Jens Karstens, Ben Manton, Mei Nelissen, Brandon Reed, Jan Inge Faleide, Ritske S. Huismans, Amar Agarwal, Graham D.M. Andrews, Peter Betlem, Joyeeta Bhattacharya, Sayantani Chatterjee, Marialena Christopoulou, Vincent J. Clementi, Eric C. Ferré, Irina Filina, Pengyuan Guo, Dustin T. Harper, Sarah Lambart, Geoffroy Mohn, Reina Nakaoka, Christian Tegner, Natalia Varela, Mengyuan Wang

Department of Earth and Atmospheric Sciences: Faculty Publications

The Palaeocene–Eocene Thermal Maximum (PETM) was a global warming event of 5–6 °C around 56 million years ago caused by input of carbon into the ocean and atmosphere. Hydrothermal venting of greenhouse gases produced in contact aureoles surrounding magmatic intrusions in the North Atlantic Igneous Province have been proposed to play a key role in the PETM carbon-cycle perturbation, but the precise timing, magnitude and climatic impact of such venting remains uncertain. Here we present seismic data and the results of a five-borehole transect sampling the crater of a hydrothermal vent complex in the Northeast Atlantic. Stable carbon isotope stratigraphy …

A Roadmap For The Human Gut Cell Atlas, Matthias Zilbauer, Kylie R. James, Mandeep Kaur, Sebastian Pott, Zhixin Li, Albert Burger, Jay R. Thiagarajah, Joseph Burclaff, Frode L. Jahnsen, Francesca Perrone, Alexander D. Ross, Gianluca Matteoli, Nathalie Stakenborg, Tomohisa Sujino, Andreas Moor, Raquel Bartolome-Casado, Espen S. Bækkevold, Ran Zhou, Bingqing Xie, Ken S. Lau, Shahida Din, Scott T. Magness, Qiuming Yao, Semir Beyaz, Mark Arends, Alexandre Denadai-Souza, Lori A. Coburn, Jellert T. Gaublomme, Richard Baldock, Irene Papatheodorou, Jose Ordovas-Montanes, Guy Boeckxstaens, Anna Hupalowska, Sarah A. Teichmann

School of Computing: Faculty Publications

The number of studies investigating the human gastrointestinal tract using various single-cell profiling methods has increased substantially in the past few years. Although this increase provides a unique opportunity for the generation of the first comprehensive Human Gut Cell Atlas (HGCA), there remains a range of major challenges ahead. Above all, the ultimate success will largely depend on a structured and coordinated approach that aligns global efforts undertaken by a large number of research groups. In this Roadmap, we discuss a comprehensive forward-thinking direction for the generation of the HGCA on behalf of the Gut Biological Network of the Human …

Antiviral Susceptibility Of Clade 2.3.4.4b Highly Pathogenic Avian Influenza A(H5n1) Viruses Isolated From Birds And Mammals In The United States, 2022, Ha T. Nguyen, Anton Chesnokov, Juan De La Cruz, Philippe Noriel Q. Pascua, Vasiliy P. Mishin, Yunho Jang, Joyce Jones, Han Di, Andrei A. Ivashchenko, Mary Lea Killian, Mia K. Torchetti, Kristina Lantz, David E. Wentworth, Charles T. Davis, Alexandre V. Ivachtchenko, Larisa V. Gubareva

United States Department of Agriculture Wildlife Services: Staff Publications

Clade 2.3.4.4b highly pathogenic avian influenza (HPAI) A(H5N1) viruses that are responsible for devastating outbreaks in birds and mammals pose a potential threat to public health. Here, we evaluated their susceptibility to influenza antivirals. Of 1,015 sequences of HPAI A(H5N1) viruses collected in the United States during 2022, eight viruses (∼0.8%) had a molecular marker of drug resistance to an FDA-approved antiviral: three adamantane-resistant (M2-V27A), four oseltamivir-resistant (NA-H275Y), and one baloxavir-resistant (PA-I38T). Additionally, 31 viruses contained mutations that may reduce susceptibility to inhibitors of neuraminidase (NA) (n = 20) or cap-dependent endonuclease (CEN) (n = 11). A panel of 22 …

White-Tailed Deer (Odocoileus Virginianus) Fawn Survival And The Influence Of Landscape Characteristics On Fawn Predation Risk In The Southern Appalachian Mountains, Usa, Adam C. Edge, Jacalyn P. Rosenberger, Cheyenne J. Yates, Andrew R. Little, Charlie H. Killmaster, Kristina L. Johannsen, David A. Osborn, John C. Kilgo, Karl V. Miller, Gino J. D’Angelo

School of Natural Resources: Faculty Publications

In the Southern Appalachian region of the United States, harvest data has indicated the occurrence of low deer densities while exposing a trend of declining white-tailed deer (Odocoileus virginianus) populations over the past several decades in northern Georgia. A triumvirate of increasing fawn predator populations reside in the Southern Appalachian Mountains including coyotes (Canis latrans), black bears (Ursus americanus) and bobcats (Lynx rufus). This region is also characterized by a homogenous landscape composed of mature forests and sparse understory vegetation, likely lacking adequate cover to offer fawns refugia from predators. Our objectives …

Implementation Of Participatory Research In Vulnerable Context: Methodological Strategies And Challenges, Bruna Larissa Seibel, Raysa Schmitz Serafim, Nathassia Santos Da Silva, José Antônio Caetano Araújo, Paul Russell Springer, Cody S. Hollist

Department of Child, Youth, and Family Studies: Faculty Publications

Participatory methods contribute to scientific rigor by highlighting the contextual needs, especially of underrepresented populations, making them protagonists in the process of social change. This article aims to present the application of a participatory research method, called Community-Based Participatory Research (CBPR), in a context of social vulnerability in southern Brazil. It seeks to discuss the challenges and strengths of the method, which provides ecological validity for the development of public policies appropriate to the context, while empowering the participants. The research has been carried out since 2019 and, among the inherent challenges, has also faced the difficulties posed by the …

Comparative Polar And Lipid Plasma Metabolomics Differentiate Kshv Infection And Disease States, Sara R. Privatt, Camila Pereira Braga, Alicia Johnson, Salum J. Lidenge, Luke Berry, John R. Ngowi, Owen Ngalamika, Andrew G. Chapple, Julius Mwaiselage, Charles Wood, John T. West, Jiri Adamec

School of Biological Sciences: Faculty Publications

Background Kaposi sarcoma (KS) is a neoplastic disease etiologically associated with infection by the Kaposi sarcoma-associated herpesvirus (KSHV). KS manifests primarily as cutaneous lesions in individuals due to either age (classical KS), HIV infection (epidemic KS), or tissue rejection preventatives in transplantation (iatrogenic KS) but can also occur in individuals, predominantly in sub-Saharan Africa (SSA), lacking any obvious immune suppression (endemic KS). The high endemicity of KSHV and human immunodeficiency virus-1 (HIV) co-infection in Africa results in KS being one of the top 5 cancers there. As with most viral cancers, infection with KSHV alone is insufficient to induce tumorigenesis. …