Digital Commons Network^™

Small Grain Cereal Cover Crops For Late Fall Or Early Spring Grazing, Kallie J. Calus

Department of Animal Science: Dissertations, Theses, and Student Research

Beef cattle operations are confronted with early spring and late fall forage deficiencies. Producers in integrated crop and livestock systems can fill forage gaps using cover crops as a forage source in between cash crops.

A five-year study evaluating forage production, growing calf performance and economics of grazing an oats cover crop planted after corn silage (CS) and high moisture corn (HMC) corn harvests was conducted. The economic analysis accounted for costs of establishing and grazing the oats and the value of calf gain to determine fall grazing system profitability. Steers had greater average daily gain grazing oats after CS …

Management Of Late Summer Planted Annual Forages For Grazing And The Impacts Of Novel Sweet Bran Plus Products On Performance And Carcass Characteristics Of Beef Finishing Steers, Devin Anthony Jakub

Department of Animal Science: Dissertations, Theses, and Student Research

Two separate grazing studies were conducted to evaluate: 1) the effects of rapeseed inclusion into late summer planted oats on the performance of growing steers during late fall and winter (Exp. 1) and 2) the effects of forage allocation on forage utilization and performance of steers grazing a late summer planted oat-rapeseed mix (Exp. 2). Variation in the corn wet milling process can result in negative effects on animal performance, nonetheless, there remains interest in further exploration and refinement of corn wet milling byproducts to achieve optimal byproduct compositions and cattle performance. Thus, another experiment was conducted to evaluate the …

Impact Of Wood-Sourced Biochar On Carbon And Nitrogen Capture In Beef Feedlot Systems, Jessica L. Sperber

Department of Animal Science: Dissertations, Theses, and Student Research

A feedlot growing and finishing experiment evaluated the effect of including pine-sourced biochar at 0.8 (growing) and 1.0% (finishing) of dietary DM on steer performance, carcass characteristics, and greenhouse gas (GHG) production (Exp 1). Two nutrient mass balance experiments were conducted during winter and summer seasons to evaluate the effect of spreading unprocessed red cedar biochar on the feedlot pen surface on manure nutrient capture and cattle performance (Exp 2). In Exp. 1, the inclusion of biochar in the growing diet did not impact steer performance. The inclusion of biochar in the finishing diet significantly reduced intake and gain, resulting …

Utilizing Online Resources To Enhance Distribution Of Competitive Animal Evaluation Knowledge And Benefits, Brooke L. Parrish

Department of Animal Science: Dissertations, Theses, and Student Research

In recent years, the shift toward online education has revealed new challenges for learners to retain information, and for educators to find new and engaging ways to present content. This mixed methods, action research study explores the need and creation of online resources for competitive horse judging through surveys and pilot groups. The study was broken into four cycles. The first was an adult learner analysis survey, distributed through email Listservs and extension social media pages, to aid in answering the research questions: what expert horse judging instructors indicate their students should be learning, and what resources they need. Based …

Evaluation Of Cattle Management For Systems With Limited Perennial Pasture, Morgan Grabau

Department of Animal Science: Dissertations, Theses, and Student Research

Due to the conversion of perennial pasture and hay land to cropland in the western corn belt region, alternative methods of cow/calf management are being used to decrease reliance on perennial forages. These include grazing corn residue and feeding cow/calf pairs in confinement. Previous research has shown that limit-feeding a diet of low-quality forage and energy-dense co-products to cows in confinement is cost-effective. However, this strategy may limit the intake of the young calf and thus their performance. A study was conducted to evaluate the impacts of two alternative calf management strategies when pairs are in confinement, early weaning or …

Feeding A New Corn Milling Coproduct To Lactating Dairy Cattle: Examination Of Whole Animal Energy And Nitrogen Balance, Addison Lee Carroll

Department of Animal Science: Dissertations, Theses, and Student Research

New coproducts are continually developed in the ethanol production industry. With that, the new product originates from the dry milling process which is unlike the traditional process as nitrogenous based particles are concentrated from the residual fiber by sieving post fermentation. Although high protein coproducts have been available since the mid 2000’s. These new products must be evaluated for chemical composition so that they can be accurately described in feed libraries that are used in commercial ration formulation software. While chemical composition provides us an initial and useful description of a feed product, in vivo nitrogen and energy balance studies …

Host Genetics And Phenotype Associations Within The Bovine Rumen Microbiome, Waseem Abbas

Department of Animal Science: Dissertations, Theses, and Student Research

Rumen microbes have a symbiotic relationship with the host where the host provides a suitable environment and microbial fermentation fulfill nearly 70% of the energy needs of the host. Rumen microbes play a central role in host performance and health. To date, most rumen microbiome studies have focused on the influence of diet on microbial species composition. In addition to dietary factors, studies have suggested that host genetic markers could influence the colonization of gastrointestinal microbiota. However, our understanding of the host-microbiome interaction and how host phenotype is influenced by the rumen microbiome is limited. This dissertation demonstrates: (1) host …

Seeding Rate Effects On Forage Mass And Vegetation Dynamics Of Cool-Season Grass Sod Interseeded With Sorghum-Sudangrass, John A. Guretzky, D. D. Redfearn

Department of Agronomy and Horticulture: Faculty Publications

Interseeding annual warm-season grasses into perennial cool-season grasses has the potential to increase summer forage mass and nutritive value. Knowledge of how seeding rate affects annual warm-season grass establishment, forage mass, and vegetation dynamics remains limited. From 2016–2017, we conducted a field experiment evaluating the effects of seeding rates on sorghum-sudangrass (Sorghum bicolor x S. bicolor var. sudanense) density and forage mass and on the frequency of occurrence of plant species in cool-season grass sod in Lincoln, NE. The experiment had a completely randomized design consisting of six replicates of four seeding rates [0, 14, 28, and 35 …

Considerations And Best Practices In Animal Science 16s Ribosomal Rna Gene Sequencing Microbiome Studies, Margaret D. Weinroth, Aeriel D. Belk, Chris Dean, Noelle Noyes, Dana K. Dittoe, Michael J. Rothrock Jr, Steven C. Ricke, Phillip R. Myer, Madison T. Henniger, Gustavo A. Ramírez, Brian B. Oakley, Katie Lynn Summers, Asha M. Miles, Taylor B. Ault-Seay, Zhongtang Yu, Jessica L. Metcalf, James E. Wells

Roman L. Hruska U.S. Meat Animal Research Center: Reports

Microbiome studies in animal science using 16S rRNA gene sequencing have become increasingly common in recent years as sequencing costs continue to fall and bioinformatic tools become more powerful and user-friendly. The combination of molecular biology, microbiology, microbial ecology, computer science, and bioinformatics—in addition to the traditional considerations when conducting an animal science study—makes microbiome studies sometimes intimidating due to the intersection of different fields. The objective of this review is to serve as a jumping-off point for those animal scientists less familiar with 16S rRNA gene sequencing and analyses and to bring up common issues and concerns that arise …

Stabilin Receptors Clear Lps And Control Systemic Inflammation, Fatima Cabral, Mustafa Al-Rahem, John Skaggs, Thushara A. Thomas, Naresh Kumar, Qian Wu, Paolo Fadda, Lianbo Yu, John M. Robinson, Jonghan Kim, Ekta Pandey, Xinghui Sun, Wael N. Jarjour, Murugesan V.S. Rajaram, Edward N. Harris, Latha P. Ganesan

Department of Biochemistry: Faculty Publications

Lipopolysaccharides (LPSs) cause lethal endotoxemia if not rapidly cleared from blood circulation. Liver sinusoidal endothelial cells (LSEC) systemically clear LPS by unknown mechanisms. We discovered that LPS clearance through LSEC involves endocytosis and lysosomal inactivation via Stabilin-1 and 2 (Stab1 and Stab2) but does not involve TLR4. Cytokine production was inversely related to clearance/endocytosis of LPS by LSEC. When exposed to LPS, Stabilin double knockout mice (Stab DK) and Stab1 KO, but not Stab2 KO, showed significantly enhanced systemic inflammatory cytokine production and early death compared with WT mice. Stab1 KO is not significantly different from Stab DK in circulatory …

Interspecific And Local Variation In Tern Chick Diets Across Nesting Colonies In The Gulf Of Maine, Keenan Yakola, Adrian Jordaan, Stephen Kress, Paula Shannon, Michelle D. Staudinger

United States Geological Survey: Staff Publications

The Gulf of Maine, USA is home to four colonial co-nesting tern species: Least Tern (Sternula antillarum), Common Tern (Sterna hirundo), Arctic Tern (Sterna paradisaea), and the federally endangered Roseate Tern (Sterna dougallii). Over three decades of visual observations of chick provisioning were compiled for a comparative dietary study in the region, including the first detailed descriptions of Least and Roseate Tern chick diets. Three prey groups comprised the majority of chick diets among tern species between 1986–2017: hake (Urophycis spp. or Enchelyopus cimbrius) 28–37% frequency of occurrence (FO), sand lance …

Evidence Of Myomir Regulation Of The Pentose Phosphate Pathway During Mechanical Load-Induced Hypertrophy, Taylor Valentino, Vandre C. Figueiredo, C. Brooks Mobley, John J. Mccarthy, Ivan Jose Vechetti Jr

Department of Nutrition and Health Sciences: Faculty Publications

Many of the molecular and cellular mechanisms discovered to regulate skeletal muscle hypertrophy were first identified using the rodent synergist ablation model. This model reveals the intrinsic capability and necessary pathways of skeletal muscle growth in response to mechanical overload (MOV). Reminiscent of the rapid cellular growth observed with cancer, we hypothesized that in response to MOV, skeletal muscle would undergo metabolic programming to sustain increased demands to support hypertrophy. To test this hypothesis, we analyzed the gene expression of specific metabolic pathways taken from transcriptomic microarray data of a MOV time course. We found an upregulation of genes involved …

Risk Based Simulations Of Sporeformers Population Throughout The Dairy Production And Processing Chain: Evaluating On-Farm Interventions In Nebraska Dairy Farms, Rhaisa A. Crespo Ramírez

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Sporeformer bacteria are ubiquitous in the farm environment. These bacteria produce enzymes that negatively affect the quality of dairy products representing a problem for the dairy industry. Two major issues associated with high levels of sporeformers in raw milk are shelf-life reduction of fluid milk and market limitations for milk powder. Specific attention has been given to the contamination of milk powders with sporeformers due to their ability to survive pasteurization and milk powder processing conditions. Hence, the control of sporeformers is crucial to benefit the whole dairy industry. Researchers have suggested that certain management practices could decrease sporeformers in …

Protein Kinase A And 59 Amp-Activated Protein Kinase Signaling Pathways Exert Opposite Effects On Induction Of Autophagy In Luteal Cells, Emilia Przygrodzka, Corrine F. Monaco, Michele R. Plewes, Guojuan Li, Jennifer R. Wood, Andrea Cupp, John S. Davis

Department of Animal Science: Faculty Publications

In the absence of pregnancy the ovarian corpus luteum undergoes regression, a process characterized by decreased production of progesterone and structural luteolysis involving apoptosis. Autophagy has been observed in the corpus luteum during luteal regression. Autophagy is a self-degradative process important for balancing sources of cellular energy at critical times in development and in response to nutrient stress, but it can also lead to apoptosis. Mechanistic target of rapamycin (MTOR) and 5′ AMP-activated protein kinase (AMPK), key players in autophagy, are known to inhibit or activate autophagy, respectively. Here, we analyzed the signaling pathways regulating the initiation of autophagy in …

Global Distribution And Richness Of Armillaria And Related Species Inferred From Public Databases And Amplicon Sequencing Datasets, Rachel A. Koch, Joshua Herr

Department of Plant Pathology: Faculty Publications

Armillaria is a globally distributed fungal genus most notably composed of economically important plant pathogens that are found predominantly in forest and agronomic systems. The genus sensulato has more recently received attention for its role in woody plant decomposition and in mycorrhizal symbiosis with specific plants. Previous phylogenetic analyses suggest that around 50 species are recognized globally. Despite this previous work, no studies have analyzed the global species richness and distribution of the genus using data derived from fungal community sequencing datasets or barcoding initiatives. To assess the global diversity and species richness of Armillaria, we mined publicly available sequencing …

Going Up Inflame: Reviewing The Underexplored Role Of Inflammatory Programming In Stress-Induced Intrauterine Growth Restricted Livestock, Zena M. Hicks, Dustin T. Yates

Department of Animal Science: Faculty Publications

The impact of intrauterine growth restriction (IUGR) on health in humans is well-recognized. It is the second leading cause of perinatal mortality worldwide, and it is associated with deficits in metabolism and muscle growth that increase lifelong risk for hypertension, obesity, hyperlipidemia, and type 2 diabetes. Comparatively, the barrier that IUGR imposes on livestock production is less recognized by the industry. Meat animals born with low birthweight due to IUGR are beset with greater early death loss, inefficient growth, and reduced carcass merit. These animals exhibit poor feed-to-gain ratios, less lean mass, and greater fat deposition, which increase production costs …

Nebline, Nov./Dec.2021

NEBLINE Newsletter Archive from Nebraska Extension in Lancaster County

Holiday Food Tips

Recipes of the Month

Traditions Rituals and Routines During a COVID-19 Holiday Season

Wise Use of Private Water and Wastewater Systems Can Make the Holidays More Peaceful

Dormant Lawn Seeding

Garden Guide: Things to Do This Month

4-H Thanks 2021 Sponsors

Farmland Trends and Lease Considerations for 2022 Workshop

Upcoming Early Childhood Trainings

Ag Society Annual Election & Meeting

Heart of 4-H Volunteer Award, Jamie Wood

Heart of 4-H Volunteer Award, Julia Plugge

Slime, Jelly Worms & Goo: Food Science 4-H Workshop, Dec. 4

Finger Knit 4-H Workshop, Dec. 11

2021 4-H Horse Awards Night

4-H Announcements …

The Sulfur Microbial Diet Is Associated With Increased Risk Of Early-Onset Colorectal Cancer Precursors, Long H. Nguyen, Yin Cao, Jinhee Hur, Raaj S. Mehta, Daniel R. Sikavi, Yiqing Wang, Wenjie Ma, Kana Wu, Mingyang Song, Edward L. Giovannucci, Eric B. Rimm, Walter C. Willett, Wendy S. Garrett, Jacques Izard, Curtis Huttenhower, Andrew T. Chan

Food for Health: Publications

Background and aims: Diet may contribute to the increasing incidence of colorectal cancer (CRC) before age 50 (early-onset CRC). Microbial metabolism of dietary sulfur produces hydrogen sulfide (H₂S), a gastrointestinal carcinogen that cannot be easily measured at scale. As a result, evidence supporting its role in early neoplasia is lacking.

Methods: We evaluated long-term adherence to the sulfur microbial diet, a dietary index defined a priori based on increased abundance of 43 bacterial species involved with sulfur metabolism, with risk of CRC precursors among 59,013 individuals who underwent lower endoscopy in the Nurses’ Health Study II …

University Research On Winter Growing Of Container-Grown Strawberries Translates To Grower's Farm Trial, Stacy A. Adams, Ellen T. Paparozzi, Ryan Pekarek, Dave P. Lambe, George Meyer, M. Elizabeth Conley, Paul Read

Department of Agronomy and Horticulture: Faculty Publications

Strawberries are only seasonally available in Nebraska (NE). If an affordable heated structure can be designed, then opportunity exists to increase on-farm income by producing strawberries off-season during high-value market periods. A series of university greenhouse trials were conducted from 2010 to 2012. The varieties Evie-2 and Seascape were identified as being most productive under a low technology growing scheme. A new research project, which ran from fall to late spring (2013–2014), was designed to determine if this production scheme would translate to a commercial grower. Varieties Seascape and Evie-2 (each at two grades indicated by +) and San Andreas …

Dietary Fiber Utilization In The Gut: The Role Of Human Gut Microbes In The Degradation And Consumption Of Xylose-Based Carbohydrates, Elizabeth Drey

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Xylans are a family of xylose-based polysaccharides naturally present in fruits, vegetables, and cereal grains. Resistant to digestion by host enzymes, xylans reach the large intestine intact, where they are utilized by members of the gut microbiome. They are initially hydrolyzed by primary degraders that utilize extracellular xylanases to cleave xylan into smaller oligomers. These xylooligosaccharides (XOS) can then either be further hydrolyzed by primary degraders or can cross-feed secondary consumers, including Bifidobacterium. While several Bifidobacterium species have metabolic systems for XOS, studies have shown these species grow poorly on longer XOS and xylan substrates. In this thesis, …

Fingerlings Mass Estimation: A Comparison Between Deep And Shallow Learning Algorithms, Adair Da Silva Oliveira Junior, Diego André Sant’Ana, Marcio Carneiro Brito Pache, Vanir Garcia, Vanessa Aparecida De Moares Weber, Gilberto Astolfi, Fabricio De Lima Weber, Geazy Vilharva Menezes, Gabriel Kirsten Menezes, Pedro Lucas França Albuquerque, Celso Soares Costa, Eduardo Quirino Arguelho De Queiroz, João Victor Araújo Rozales, Milena Wolff Ferreira, Marco Hiroshi Naka, Hemerson Pistori

School of Computing: Faculty Publications

The paper presents some results regarding the automatic mass estimation of Pintado Real fingerlings, using machine learning techniques to support the fish production process. For this purpose, an image dataset called FISHCV1206FSEG, was created which is composed of 1206 images of fingerlings with their respective annotated masses. Through the fish contours, the area and perimeter were extracted, and submitted to the J48, SVM, and KNN classification algorithms and a linear regression algorithm. The images were also submitted to ResNet50, In- ceptionV3, Exception, VGG16, and VGG19 convolutional neural networks. As a result, the classification algorithm J48 reached an accuracy of 58.2% …

Qupath Digital Immunohistochemical Analysis Of Placental Tissue, Ashley L. Hein, Maheswari Mukherjee, Geoffrey A. Talmon, Sathish Kumar Natarajan, Tara M. Nordgren, Elizabeth Lyden, Corrine K. Hanson, Jesse L. Cox, Annelisse Santiago‑Pintado, Mariam A. Molani, Matthew Van Ormer, Maranda Thompson, Melissa K. Thoene, Aunum Akhter, Ann Anderson‑Berry, Ana G. Yuil-Valdes

Department of Nutrition and Health Sciences: Faculty Publications

Background: QuPath is an open‑source digital image analyzer notable for its user‑friendly design, cross‑platform compatibility, and customizable functionality. Since it was first released in 2016, at least 624 publications have reported its use, and it has been applied in a wide spectrum of settings. However, there are currently limited reports of its use in placental tissue. Here, we present the use of QuPath to quantify staining of G‑protein coupled receptor 18 (GPR18), the receptor for the pro‑resolving lipid mediator Resolvin D2, in placental tissue. Methods: Whole slide images of vascular smooth muscle (VSM) and extravillous trophoblast (EVT) cells stained …

The Effects Of Omega-3 Pufa Infusions During Late Gestation On Developmental Pathologies In The Intrauterine Growth Restricted Fetus, Taylor A. Lacey

Department of Animal Science: Dissertations, Theses, and Student Research

Low birthweight due to intrauterine growth restriction is associated with metabolic disorders after birth. Our 1^st study assessed deficits in skeletal muscle glucose metabolism and pancreatic β cell function in IUGR fetal sheep. We aimed to evaluate the effectiveness of daily intravenous infusions of the anti-inflammatory ω-3 polyunsaturated fatty acid (PUFA), eicosapentaenoic acid (EPA), as a means of improving deficits previously observed in the IUGR fetus by targeting fetal systemic inflammation. The presence of systemic inflammation in IUGR fetuses was evident by increased total circulating populations of total leukocytes, lymphocytes, and monocytes. However, these were …

Relationships Among Toilet Sharing, Water Source Locations, And Handwashing Places Without Observed Soap: A Cross-Sectional Study Of The Richest Households In Bangladesh, Mazbahul G. Ahamad, Mark Burbach, Fahian Tanin

School of Natural Resources: Faculty Publications

Background: A high percentage of the richest households in Bangladesh lack soap at their handwashing places, a problem that is typically considered to be one of the poor. Objective: We investigated toilet sharing practices, locations of water sources, and relevant sociodemographic factors associated with the observed handwashing places that lack soap in the richest (ninth wealth decile) households in Bangladesh. Methods: We used data from the 2017-18 Bangladesh Demographic and Health (BDHS) Survey. Logistic regression technique was used to investigate how toilet sharing practices, water source locations, and different sociodemographic factors were associated with observed handwashing places without soap. Results: …

Perches As Cooling Devices For Reducing Heat Stress In Caged Laying Hens: A Review, Jiaying Hu, Yijie Xiong

Department of Animal Science: Faculty Publications

Heat stress is one of the most detrimental environmental challenges affecting the biological process and the related production performance of farm animals, especially in poultry. Commercial laying hens have been bred (selected) for high egg production, resulting in increased sensitivity to heat stress due to breeding-linked metabolic heat production. In addition, laying hens are prone to heat stress due to their inadequate species-specific cooling mechanisms resulting in low heat tolerance. In addition, hens have no sweat glands and feathering covers almost their entire body to minimize body heat loss. The poultry industry and scientists are developing cooling methods to prevent …

Dynamic Evolution And Correlation Between Metabolites And Microorganisms During Manufacturing Process And Storage Of Fu Brick Tea, Jing Li, Ran Xu, Joseph Brake, Lizeng Cheng, Jie Wu, Xiaobin Wu

Department of Biochemistry: Faculty Publications

Fu brick tea (FBT) is one of the major brands of dark tea. Microbial fermentation is considered the key step in the development of the special characteristics of FBT. The systemic corelationship of the microbiome and metabolomics during manufacture of Fu brick tea is not fully understood. In this study, we comprehensively explored the microbiome and metabolite dynamic evolution during the FBT manufacturing processes, and revealed decisive factors for the quality and safety of FBT based on the grouped methods of metabolomics combined with biochemical measurements, microbiome sequencing combined with quantitative polymerase chain reaction (PCR), and multiplex analysis. Both the …

Transcriptomics Reveals The Putative Mycoparasitic Strategy Of The Mushroom Entoloma Abortivum On Species Of The Mushroom Genus Armillaria, Rachel A. Koch, Joshua Herr

Department of Plant Pathology: Faculty Publications

During mycoparasitism, a fungus—the host—is parasitized by another fungus—the mycoparasite. The genetic underpinnings of these relationships have been best characterized in ascomycete fungi. However, within basidiomycete fungi, there are rare instances of mushroom-forming species parasitizing the reproductive structures, or sporocarps, of other mushroom-forming species, which have been rarely investigated on a genetic level. One of the most enigmatic of these occurs between Entoloma abortivum and species of Armillaria, where hyphae of E. abortivum are hypothesized to disrupt the development of Armillaria sporocarps, resulting in the formation of carpophoroids. However, it remains unknown whether carpophoroids are the direct result of a …

Impact Of Feeding Syngenta Enogen® Feed Corn Compared To Control Corn In Different Diet Scenarios To Finishing Beef Cattle, Stacia M. Volk, Hannah H. Wilson, Kathryn J. Hanford, James C. Macdonald, Galen E. Erickson

Department of Animal Science: Faculty Publications

The objective of this pooled statistical analysis was to evaluate Syngenta Enogen® Feed Corn (EFC) versus conventional corn (CON) when fed as either dry-rolled corn (DRC) or highmoisture corn (HMC) for effects on finishing beef cattle performance and carcass characteristics. Corns were evaluated in diets with byproduct inclusion rates of 0, 15, 18, 20, and 30% distiller grains or 25 and 35% Sweet Bran® (a commercial corn gluten feed product). Seven trials (n = 1856) consisting of 200 pen means comparing 26 diet treatments were analyzed using regression in a pooled analysis. When EFC was processed as DRC, the gain …

Output Consistency Scale To Standardize Ostomate Output Description In Clinical Practice And Studies, Lisa Whisenhunt, Linda Xu, Fan Yang, Jacques Izard

Food for Health: Publications

Stool descriptors have become popular due to the large diffusion of the Bristol Stool Form Scale (BSFS) via clinical studies, clinical trials, and social media. The applications have been numerous and centered around standardization of terminology that can be used by health care professionals and patients alike, as well as individuals interested in their wellness and the associated partners in the wellness industry. For a portion of the population, the digestive content is rerouted to an external manufactured pouch or bag, making the use of the BSFS visual descriptors of stool difficult. From day one post-resection surgery, ostomates are challenged …

Recent Applications Of Quantitative Systems Pharmacology And Machine Learning Models Across Diseases, Sara Sadat Aghamiri1, Rada Amin, Tomáš Helikar

Department of Biochemistry: Faculty Publications

Quantitative systems pharmacology (QSP) is a quantitative and mechanistic platform describing the phenotypic interaction between drugs, biological networks, and disease conditions to predict optimal therapeutic response. In this meta-analysis study, we review the utility of the QSP platform in drug development and therapeutic strategies based on recent publications (2019–2021). We gathered recent original QSP models and described the diversity of their applications based on therapeutic areas, methodologies, software platforms, and functionalities. The collection and investigation of these publications can assist in providing a repository of recent QSP studies to facilitate the discovery and further reusability of QSP models. Our review …