Digital Commons Network^™

Empezando Con Dash (Getting Started With Dash)

United States Natonal Institutes of Health: Materials

Empiece a bajar su presión arterial, con la ayuda del plan de alimentación DASH, siguiendo los cinco pasos de esta hoja de información.

On The Move To Better Heart Health For African Americans

United States Natonal Institutes of Health: Materials

This booklet created specifically for African Americans explains what heart disease is and provides helpful tips to improve heart health.

Consejos Para Reducir La Sal Y El Sodio (Tips To Reduce Salt And Sodium)

United States Natonal Institutes of Health: Materials

Esta hoja de información provee consejos para ayudarle a reducir la sal y el sodio en las comidas que usted escoge.

Por Qué Funciona El Plan De Alimentación Dash (Why The Dash Eating Plan Works)

United States Natonal Institutes of Health: Materials

Esta hoja de información provee un resumen del plan de alimentación llamado DASH, que puede ayudar a bajar la presión arterial.

Reducing Allergens In Your Home Fact Sheet

United States Natonal Institutes of Health: Materials

If your asthma is triggered by allergies, using multiple strategies to remove or minimize indoor allergens (such as dust mites or pet dander) may be to blame.

Advancing Heart, Lung, Blood, And Sleep Research (January 2021)

United States Natonal Institutes of Health: Materials

Advancing Heart, Lung, Blood, and Sleep Research is a brochure that highlights major NHLBI programs, partnership activities, as well as recent advances in science.

Heart-Healthy Home Cooking African American Style

United States Natonal Institutes of Health: Materials

Prepare your favorite African American dishes in ways that protect you and your family from heart disease and stroke.

Protecting Youth Mental Health: The U.S. Surgeon General's Advisory

United States Natonal Institutes of Health: Materials

Conclusion

As we learn the lessons of the COVID-19 pandemic, and start recovering and rebuilding, we have an opportunity to offer a more comprehensive, more fulfilling, and more inclusive vision of what constitutes public health. And for a generation of children facing unprecedented pressures and stresses, day in and day out, change can’t come soon enough.

It won’t come overnight. Many of the recommendations offered in this Advisory require structural buy-in and change.

But everyone has a role to play in combating this mental health pandemic. Without individual engagement, no amount of energy or resources can overcome the biggest barrier …

Who Counts As A Citizen? Toward An Interdisciplinary Understanding Of Statelessness, Cole S. Kovarik

Nebraska Anthropologist

This paper highlights several limitations of the dominant legal framework for addressing statelessness and incorporates sociological understandings of citizenship and nationality into a revised approach to the issue. The analysis examines various national group dynamics surrounding the issue of statelessness for the Rohingya of Myanmar and concludes that legal citizenship status is neither the sole cause of nor the sole solution for the crisis that has emerged. It concludes with an assessment of the social dynamics that lead to statelessness and recommendations for future research.

Using Photovoice To Understand And Amplify Youth Voices To Prevent Sexual And Relationship Violence, Victoria Banyard, Katie Edwards, Ramona Herrington, Skyler Hopfauf, Briana Simon, Linda Shroll

Nebraska Center for Research on Children, Youth, Families, and Schools: Faculty Publications

Aims: Efforts to improve prevention of sexual and relationship violence (SRV) among adolescents call for more centering of youth voices, experiences, and skills to design prevention programs that incorporate youth engagement rather than those that are designed by adults for youth. Amplifying the voices of historically marginalized youth are especially needed. Photovoice (PV) is a participatory action method that can empower youth and generate prevention knowledge.

Methods: The current project used PV to engage youth in late middle and early high school to discuss how they could work to prevent SRV in their community. A convenience sample of nine youth …

Antibiotic Resistance In Manure- Amended Agricultural Soils, Maranatha Zelt, Zachary Staley, Xu Li, Bing Wang, Daniel N. Miller, Amy Schmidt

Nebraska Beef Cattle Reports

Manure application to agricultural land benefits soil health and agronomic yields. However, as antibiotic resistance becomes a more serious threat to public health, there is concern that antibiotic resistance originating from livestock manure could impact human health through contamination of the environment or food. This study sought to quantify this risk by monitoring concentrations of antibiotic resistance bacteria and genes in fallow soil during the period of October through April, representing fall manure application through spring planting. Resistance to three common antibiotics— tylosin, azithromycin and tetracycline— was monitored following application of fresh, stockpiled, or composted beef feedlot manure, or inorganic …

Visual Control Of Refuge Recognition In The Whip Spider Phrynus Marginemaculatus, Kaylyn A.S. Flanigan, Daniel D. Wiegmann, Patrick Casto, Vincent J. Coppola, Natasha R. Flesher, Eileen Hebets, Verner Peter Bingman

Eileen Hebets Publications

Amblypygids, or whip spiders, are nocturnally active arachnids which live in structurally complex environments. Whip spiders are excellent navigators that can re-locate a home refuge without relying on visual input. Therefore, an open question is whether visual input can control any aspect of whip spider spatial behavior. In the current study, Phrynus marginemaculatus were trained to locate an escape refuge by discriminating between differently oriented black and white stripes placed either on the walls of a testing arena (frontal discrimination) or on the ceiling of the same testing arena (overhead discrimination). Regardless of the placement of the visual stimuli, the …

Identification And Quantification Of 11 Airborne Biochemicals Emitted By The Brown Recluse And Another Primitive Hunting Spider Using Headspace Solid-Phase Microextraction-Gc/Ms, Zachary Foulks, Jennifer Parks, William Stoecker, Charles Kristensen, Eileen A. Hebets, Honglan Shi

Eileen Hebets Publications

Loxosceles reclusa, or brown recluse spider, is a harmful household spider whose habitat extends throughout the Midwest in the USA and other regions in the world. The pheromones and other biomolecules that facilitate signaling for brown recluses and other spider species are poorly understood. A rapid and sensitive method is needed to analyze airborne spider signaling biomolecules to better understand the structure and function of these biochemicals in order to control the population of the spiders. In this study, we developed a novel headspace solid-phase microextraction (HS-SPME)-GC/MS method to analyze potential pheromones and biomolecules emitted by the brown recluse …

Teaching Metabolism In Upper-Division Undergraduate Biochemistry Courses Using Online Computational Systems And Dynamical Models Improves Student Performance, Christine S. Booth, Changsoo Song, Michelle E. Howell, Achilles Rasquinha, Aleš Saska, Resa M. Helikar, Sharmin M. Sikich, Brain A. Couch, Karin Van Dijk, Rebecca Roston, Tomáš Helikar

Department of Biochemistry: Faculty Publications

Understanding metabolic function requires knowledge of the dynamics, interdependence, and regulation of metabolic networks. However, multiple professional societies have recognized that most undergraduate biochemistry students acquire only a surface-level understanding of metabolism. We hypothesized that guiding students through interactive computer simulations of metabolic systems would increase their ability to recognize how individual interactions between components affect the behavior of a system under different conditions. The computer simulations were designed with an interactive activity (i.e., module) that used the predict–observe–explain model of instruction to guide students through a process in which they iteratively predict outcomes, test their predictions, modify the interactions …

Long Non-Coding Rna Meg3 Deficiency Impairs Glucose Homeostasis And Insulin Signaling By Inducing Cellular Senescence Of Hepatic Endothelium In Obesity, Xiao Cheng, Mohamed Sham Shihabudeen Haider Ali, Matthew Moran, Martonio Ponte Viana, Sarah L. Schlichte, Matthew C. Zimmerman, Oleh Khalimonchuk, Mark W. Feinberg, Xinghui Sun

Department of Biochemistry: Faculty Publications

Obesity-induced insulin resistance is a risk factor for diabetes and cardiovascular disease. However, the mechanisms underlying endothelial senescence in obesity, and how it impacts obesity-induced insulin resistance remain incompletely understood. In this study, transcriptome analysis revealed that the long non-coding RNA (lncRNA) Maternally expressed gene 3 (Meg3) is one of the top differentially expressed lncRNAs in the vascular endothelium in diet-induced obese mice. Meg3 knockdown induces cellular senescence of endothelial cells characterized by increased senescence-associated β–galactosidase activity, increased levels of endogenous superoxide, impaired mitochondrial structure and function, and impaired autophagy. Moreover, Meg3 knockdown causes cellular senescence of hepatic endothelium in …

Integrative Network Analyses Of Transcriptomics Data Reveal Potential Drug Targets For Acute Radiation Syndrome, Robert Moore, Bhanwar Lal Puniya, Robert Powers, Chittibabu Guda, Kenneth W. Bayles, David Berkowitz, Tomas Helikar

Department of Biochemistry: Faculty Publications

Recent political unrest has highlighted the importance of understanding the short- and long-term effects of gamma-radiation exposure on human health and survivability. In this regard, effective treatment for acute radiation syndrome (ARS) is a necessity in cases of nuclear disasters. Here, we propose 20 therapeutic targets for ARS identified using a systematic approach that integrates gene co-expression networks obtained under radiation treatment in humans and mice, drug databases, disease-gene association, radiation-induced differential gene expression, and literature mining. By selecting gene targets with existing drugs, we identified potential candidates for drug repurposing. Eight of these genes (BRD4, NFKBIA, CDKN1A, TFPI, MMP9, …

Lysosomal Slc46a3 Modulates Hepatic Cytosolic Copper Homeostasis, Jung-Hwan Kim, Tsutomu Matsubara, Jaekwom Lee, Cristina Fenollar-Ferrer, Kyungreem Han, Donghwan Kim, Shang Jia, Christopher J. Chang, Heejung Yang, Tomokazu Nagano, Kristopher W. Krausz, Sun Hee Yim, Frank J. Gonzalez

Department of Biochemistry: Faculty Publications

The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatic toxicity associated with prominent lipid accumulation in humans. Here, the authors report that the lysosomal copper transporter SLC46A3 is induced by TCDD and underlies the hepatic lipid accumulation in mice, potentially via effects on mitochondrial function. SLC46A3 was localized to the lysosome where it modulated intracellular copper levels. Forced expression of hepatic SLC46A3 resulted in decreased mitochondrial membrane potential and abnormal mitochondria morphology consistent with lower copper levels. SLC46A3 expression increased hepatic lipid accumulation similar to the known effects of TCDD exposure in mice and humans. The TCDD-induced hepatic triglyceride accumulation was significantly …

Covid19 Disease Map, A Computational Knowledge Repository Of Virus–Host Interaction Mechanisms, Marek Ostaszewski, Tomáš Helikar, Bhanwar Lal Puniya, A Host Of Co-Authors, Covid-19 Disease Map Community

Department of Biochemistry: Faculty Publications

We need to effectively combine the knowledge from surging literature with complex datasets to propose mechanistic models of SARS-CoV-2 infection, improving data interpretation and predicting key targets of intervention. Here, we describe a large-scale community effort to build an open access, interoperable and computable repository of COVID-19 molecular mechanisms. The COVID-19 Disease Map (C19DMap) is a graphical, interactive representation of disease-relevant molecular mechanisms linking many knowledge sources. Notably, it is a computational resource for graph-based analyses and disease modelling. To this end, we established a framework of tools, platforms and guidelines necessary for a multifaceted community of biocurators, domain experts, …

The Potential Use Of Radiomics With Pre-Radiation Therapy Mr Imaging In Predicting Risk Of Pseudoprogression In Glioblastoma Patients, Michael J. Baine, Justin Burr, Qian Du, Chi Zhang, Xiaoying Liang, Luke Krajewski, Laura Zima, Gerard Rux, Chi Zhang, Dandan Zheng

School of Biological Sciences: Faculty Publications

Glioblastoma (GBM) is the most common adult glioma. Differentiating post-treatment effects such as pseudoprogression from true progression is paramount for treatment. Radiomics has been shown to predict overall survival and MGMT (methylguanine-DNA methyltransferase) pro- moter status in those with GBM. A potential application of radiomics is predicting pseudoprogression on pre-radiotherapy (RT) scans for patients with GBM. A retrospective review was performed with radiomic data analyzed using pre-RT MRI scans. Pseudoprogression was defined as post-treatment findings on imaging that resolved with steroids or spontaneously on subsequent imaging. Of the 72 patients identified for the study, 35 were able to be assessed …

Opposing Community Assembly Patterns For Dominant And Nondominant Plant Species In Herbaceous Ecosystems Globally, Carlos Alberto Arnillas, Elizabeth T. Borer, Eric W. Seabloom, Juan Alberti, Selene Baez, Jonathan D. Bakker, Elizabeth H. Boughton, Yvonne M. Buckley, Miguel Nuno Bugalho, Ian Donohue, John Dwyer, Jennifer Firn, Riley Gridzak, Nicole Hagenah, Yann Hautier, Aveliina Helm, Anke Jentsch, Johannes M. H. Knops, Kimberly J. Komatsu, Lauri Laanisto, Ramesh Laungani, Rebecca Mcculley, Joslin L. Moore, John W. Morgan, Pablo Luis Peri, Sally A. Power, Jodi Price, Mahesh Sankaran, Brandon Schamp, Karina Speziale, Rachel Standish, Risto Virtanen, Marc W. Cadotte

School of Biological Sciences: Faculty Publications

Biotic and abiotic factors interact with dominant plants—the locally most frequent or with the largest coverage—and nondominant plants differently, partially because dominant plants modify the environment where nondominant plants grow. For instance, if dominant plants compete strongly, they will deplete most resources, forcing nondominant plants into a narrower niche space. Conversely, if dominant plants are constrained by the environment, they might not exhaust available resources but instead may ameliorate environmental stressors that usually limit nondominants. Hence, the nature of interactions among nondominant species could be modified by dominant species. Furthermore, these differences could translate into a disparity in the phylogenetic …

Targeted Manipulation Of Abundant And Rare Taxa In The Daphnia Magna Microbiota With Antibiotics Impacts Host Fitness Differentially, Reilly O. Cooper, Janna M. Vavra, Clayton E. Cressler

School of Biological Sciences: Faculty Publications

Host-associated microbes contribute to host fitness, but it is unclear whether these contributions are from rare keystone taxa, numerically abundant taxa, or interactions among community members. Experimental perturbation of the microbiota can highlight functionally important taxa; however, this approach is primarily applied in systems with complex communities where the perturbation affects hundreds of taxa, making it difficult to pinpoint contributions of key community members. Here, we use the ecological model organism Daphnia magna to examine the importance of rare and abundant taxa by perturbing its relatively simple microbiota with targeted antibiotics. We used sublethal antibiotic doses to target either rare …

Differential Survival Of Non-O157 Shiga Toxigenic Escherichia Coli In Simulated Cattle Feedlot Runoff, Lisa M. Durso, John E. Gilley, Daniel N. Miller

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Environmental survival time is important when evaluating adverse health outcomes from foodborne pathogens. Although outbreaks associated with manure-impacted irrigation or runoff water are relatively infrequent, their broad scope, regulatory importance, and severe health outcomes highlight the need to better understand the environmental survival of manure-borne pathogens. Shiga toxigenic Escherichia coli (STEC) are excreted in feces and persist in the environment until they die or recolonize a new host. Surface waters contaminated with manure-borne STEC can infect humans through drinking and recreational water use or irrigated crops that are minimally cooked. In this study, manure-impacted water microcosms mimicking beef cattle feedlot …

Editorial: Predictive Modeling Of Human Microbiota And Their Role In Health And Disease, Hyun-Seob Song, Stephen R. Lindemann, Dong-Yup Lee

Department of Agricultural and Biological Systems Engineering: Faculty Publications

No abstract provided.

Frontier: Discipline-Based Education Research To Advance Authentic Learning In Agricultural And Biological Engineering, Heidi A. Diefes-Dux

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Discipline-based education research (DBER) is research activity aimed at investigating “learning and teaching in a discipline from a perspective that reflects the discipline’s priorities, worldview, knowledge, and practices” for the purpose of producing research-based evidence to improve education in that discipline. DBER arose out of concerns about the quality of post-secondary science education. Physics, chemistry, engineering, biology, geosciences, and astronomy education each have unique DBER histories in the U.S. that date back to the late 1800s or early 1900s when colleges and university systems were expanding and formalizing. The DBER fields accelerated in the 1950s and 1960s as a result …

Lipid Droplet Membrane Proteome Remodeling Parallels Ethanol-Induced Hepatic Steatosis And Its Resolution, Carol A. Casey, Terrence M. Donohue Jr., Jacy L. Kubik, Vikas Kumar, Michael J. Naldrett, Nicholas T. Woods, Cole P. Frisbie, Mark A. Mcniven, Paul G. Thomes

Nebraska Center for Biotechnology: Faculty and Staff Publications

Abstract Lipid droplets (LDs) are composed of neutral lipids enclosed in a phospholipid monolayer, which harbors membrane-associated proteins that regulate LD functions. Despite the crucial role of LDs in lipid metabolism, remodeling of LD protein composition in disease contexts, such as steatosis, remains poorly understood. We hypothesized that chronic ethanol consumption, subsequent abstinence from ethanol, or fasting differentially affects the LD membrane proteome content and that these changes influence how LDs interact with other intracellular organelles. Here, male Wistar rats were pair-fed liquid control or ethanol diets for 6 weeks, and then, randomly chosen animals from both groups were either …

Introduction To Doing Fieldwork At Home: The Ethnography Of Education In Familiar Contexts: In The Field At Home; Onward, & Bibliography, Loukia K. Sarroub, Claire Nicholas

Department of Teaching, Learning, and Teacher Education: Faculty Publications

In this volume, we attempt to better understand ethnographic research on education in local contexts wherein the researcher has regular contact and social relationships with the intended research participants. Recent disciplinary trends find ethnographers increasingly engaged in research in settings familiar to them, such as their own workplaces, leisure spaces, neighborhoods, and communities. The study of such practices illuminates interconnected methodological, ethical, and analytical dilemmas. It also offers opportunities for methodological innovation, explicates and challenges the effects of educational policies and practices, and interrogates and develops theories about educational structures, policies, and experiences. Our aim is to highlight the agency …

Impact Of Masters Choice Corn Silage On Nutrient Digestion In Growing Cattle, Jiehua Xiong, Mitch M. Norman, Hannah C. Wilson, Caleb Crabtree, Galen E. Erickson

Nebraska Beef Cattle Reports

No abstract provided.

Effects Of Monensin And Protein Type On Performance Of Yearling Steers Grazing Smooth Bromegrass Pastures, Z. E. Carlson, K. Butterfield, Levi Mcphillips, Galen E. Erickson, M. E. Drewnoski, J. C. Macdonald

Nebraska Beef Cattle Reports

Summary with Implications

Two-year study evaluated the effects of monensin on protein type, either rumen degradable or rumen undegradable, with yearling steers grazing smooth bromegrass pastures. Steers were supplemented soybean meal (rumen degradable protein) or nonenzymatically browned soybean meal (rumen undegradable protein) at isonitrogenous levels to dried distillers grains plus solubles provided at 0.50% BW. Likewise, steers were provided either zero or 200 mg/hd/d of monensin for a total of six treatments with a 2 × 3 (no protein, RDP, or RUP) factorial design. There was no interaction of monensin by protein type. Providing monensin to grazing yearlings did not …

2021 Nebraska Beef Cattle Report

Nebraska Beef Cattle Reports

Cow-Calf Nutrition and Management: Metabolic Profile Associated with Pre-Breeding Puberty Status in Range Beef Heifers 5 • Milk Production Impacts on Cow Reproductive and Calf Growth Performance 8 • Genetic Selection Tools: Using Pooling to Capture Commercial Data for Inclusion in Genetic Evaluations 11 • Categorization of Birth Weight Phenotypes for Inclusion in Genetic Evaluations Using a Deep Neural Network 14 • Genetic Parameter Estimates for Age at Slaughter and Days to Finish in a Multibreed Population 16

Growing Calf and Yearling Management: Effects of Monensin and Protein Type on Performance of Yearling Steers Grazing Smooth Bromegrass Pastures 18 • …

Genetic Parameter Estimates For Age At Slaughter And Days To Finish In A Multibreed Population, Lindsay R. Upperman, Larry A. Kuehn, Matthew L. Spangler

Nebraska Beef Cattle Reports

No abstract provided.