Digital Commons Network^™

Charting Early Trajectories Of Executive Control With The Shape School, Caron A. C. Clark, Tiffany D. Sheffield, Nicolas Chevalier, Jennifer Mize Nelson, Sandra A. Wiebe, Kimberly Andrews Espy

Department of Psychology: Faculty Publications

Despite acknowledgement of the importance of executive control for learning and behavior, there is a dearth of research charting its developmental trajectory as it unfolds against the background of children’s sociofamilial milieus. Using a prospective, cohort-sequential design, this study describes growth trajectories for inhibitory control and cognitive flexibility across the preschool period in relation to child sex and sociofamilial resources. At ages 3, 3.75, 4.5, and 5.25 years, children (N = 388) from a broad range of social backgrounds were assessed using the Shape School, a graduated measure of executive control incorporating baseline, inhibitory control, and cognitive flexibility conditions. …

United States National Science Foundation (Nsf) Scientific Integrity Policy

Copyright, Fair Use, Scholarly Communication, etc.

United States National Science Foundation (NSF) Scientific Integrity Policy

The Impact Of Social Exclusion On Anticipatory Attentional Processing, John E. Kiat, Jacob E. Cheadle, Bridget J. Goosby

Department of Sociology: Faculty Publications

The importance of understanding how we anticipate and prepare for social rejection is underscored by the mental and physical toll of continual social vigilance. In this study, we investigate the impact of social rejection on anticipatory attentional processes using the well-known Cyberball task, a paradigm in which participants engage in a game of catch with virtual avatars who after an initial period of fair-play (inclusion condition) then exclude the participant from the game (exclusion condition). The degree of anticipatory attention allocated by subjects towards the avatars was assessed by measuring P3b responses towards the avatars’ preparatory actions (i.e. the phase …

Indicators Of Community Physical Activity Resources And Opportunities And Variation By Community Sociodemographic Characteristics: A Scoping Review, Ann E. Rogers, Michaela A. Schenkelberg, Peter Stoepker, Danielle Westmark, Deepa Srivastava, David A. Dzewaltowski

Department of Child, Youth, and Family Studies: Faculty Publications

Objective: This scoping review synthesizes studies examining community-level variability in physical activity resource (assets) and opportunity (organized group physical activity services) availability by community sociodemographic characteristics to describe methodologies for measuring resources/opportunities, indicators characterizing availability, and associations between community-level sociodemographic characteristics and availability.

Methods: A systematic search was conducted in MEDLINE, CINAHL, PsycINFO, and Scopus for literature through 2022. Eligible studies quantitatively examined measures of physical activity resource/opportunity availability by community-level racial, ethnic, and/or socioeconomic characteristics within geospatially defined communities. Extracted data included: community geospatial definitions, sociodemographic characteristics assessed, methodologies for measuring and indicators of community physical activity …

Factors Associated With Gaps In Naloxone Knowledge: Evidence From A 2022 Great Plains Survey, Spencer Cooper‑Ohm, Patrick Habecker, Ryan Humeniuk, Rick A. Bevins

Department of Sociology: Faculty Publications

Background The rising prevalence of fast-acting opioids in the USA suggests the increased need for non-professional first responder administration of naloxone. Effective administration of naloxone during an overdose requires that bystanders are familiar with, have access to, and know how to use naloxone.

Methods Drawing on a statewide, address-based sample of Nebraskan adults, we used logistic regression to predict the likelihood of respondents’ familiarity with, access to, and competency to administer naloxone. Our independent variables included measures indicating proximity to drug use, perceived community stigma toward people who use drugs, and demographic data.

Results There were significant gaps in naloxone …

Discussion On “Spatial+: A Novel Approach To Spatial Confounding” By Dupont, Wood, And Augustin, Brian J. Reich, Shu Yang, Yawen Guan

Department of Statistics: Faculty Publications

Congratulations to the authors for this thoughtful and timely contribution to the spatial confounding literature. The intuitive nature of the method and simplicity of the estimation procedure will surely make Spatial+ popular with practitioners, and the theoretical developments are a major advance for researchers in this area. There is much to discuss! We have formatted our discussion in two sections: in Section 2 we consider the assumptions and statistical properties of Spatial+, and in Section 3 we examine how Spatial+ fits in the wider literature on spatial causal inference.

Prebiotic Proanthocyanidins Inhibit Bile Reflux–Induced Esophageal Adenocarcinoma Through Reshaping The Gut Microbiome And Esophageal Metabolome, Katherine M. Weh, Connor L. Howard, Yun Zhang, Bridget A. Tripp, Jennifer Clarke, Amy B. Howell, Joel H. Rubenstein, Julian A. Abrams, Maria Westerhoff, Laura A. Kresty

Department of Statistics: Faculty Publications

The gut and local esophageal microbiome progressively shift from healthy commensal bacteria to inflammation-linked pathogenic bacteria in patients with gastroesophageal reflux disease, Barrett’s esophagus, and esophageal adenocarcinoma (EAC). However, mechanisms by which microbial communities and metabolites contribute to reflux-driven EAC remain incompletely understood and challenging to target. Herein, we utilized a rat reflux-induced EAC model to investigate targeting the gut microbiome–esophageal metabolome axis with cranberry proanthocyanidins (C-PAC) to inhibit EAC progression. Sprague-Dawley rats, with or without reflux induction, received water or C-PAC ad libitum (700 μg/rat/day) for 25 or 40 weeks. C-PAC exerted prebiotic activity abrogating reflux-induced dysbiosis and mitigating …

Command Injection Attacks In Smart Grids: A Survey, Muhammad Usama, Muhammad Naveed Aman

School of Computing: Faculty Publications

Cybersecurity is important in the realization of various smart grid technologies. Several studies have been conducted to discuss different types of cyberattacks and provide their countermeasures. The false command injection attack (FCIA) is considered one of the most critical attacks that have been studied. Various techniques have been proposed in the literature to detect FCIAs on different components of smart grids. The predominant focus of current surveys lies on FCIAs and detection techniques for such attacks. This article presents a survey of existing works on FCIAs and classifies FCIAs in smart grids according to the targeted component. The impacts of …

The Emerging Role Of Non-Coding Rnas (Ncrnas) In Plant Growth, Development, And Stress Response Signaling, Amit Yadav, Jyotirmaya Mathan, Arvind Kumar Dubey, Anuradha Singh

Center for Plant Science Innovation: Faculty Publications

Plant species utilize a variety of regulatory mechanisms to ensure sustainable productivity. Within this intricate framework, numerous non-coding RNAs (ncRNAs) play a crucial regulatory role in plant biology, surpassing the essential functions of RNA molecules as messengers, ribosomal, and transfer RNAs. ncRNAs represent an emerging class of regulators, operating directly in the form of small interfering RNAs (siRNAs), microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). These ncRNAs exert control at various levels, including transcription, posttranscription, translation, and epigenetic. Furthermore, they interact with each other, contributing to a variety of biological processes and mechanisms associated with stress resilience. …

Unearthing Green Potential: Assessing The State Of Managed Urban Landscape Curricula In Minnesota’S Higher Education Institutions, Michael R. Barnes, Heana A. Campagna, Becky Haddad, Eric Watkins

Department of Agricultural Leadership, Education, and Communication: Faculty Publications

As urbanization increases, managed urban landscapes are frequently the mode through which people experience nature and where careers in natural resources are increasing. There is a lack of knowledge related to curricula and programs where students are exposed to managed urban landscapes and careers related to them. We aimed to evaluate the current status of managed urban landscape curricula (MULC) in undergraduate programs in Minnesota through a systematic investigation of programs and courses at higher education institutions. All undergraduate courses offered by included higher education institutions were reviewed to determine the presence, absence, or possibility of MULC based on the …

Reducing Loneliness And Improving Social Support Among Older Adults Through Different Modalities Of Personal Voice Assistants, Valerie Jones, Changmin Yan, Marcia Shade, Julie Blaskewicz Boron, Zhengxu Yan, Hyeon Jung Heselton, Kate Johnson, Victoria Dube

College of Journalism and Mass Communications: Faculty Publications

This study examines the potential of AI-powered personal voice assistants (PVAs) in reducing loneliness and increasing social support among older adults. With the aging population rapidly expanding, innovative solutions are essential. Prior research has indicated the effectiveness of various interactive communication technologies (ICTs) in mitigating loneliness, but studies focusing on PVAs, particularly considering their modality (audio vs. video), are limited. This research aims to fill this gap by evaluating how voice assistants, in both audio and video formats, influence perceived loneliness and social support. This study examined the impact of voice assistant technology (VAT) interventions, both audio-based (A-VAT) and video-based …

Predicting Sedentarism And Its Impact On Caloric Requirements, Jacob Michels, John C. Beghin

Yeutter Institute International Trade Policy Review

A recent study conducted by PhD candidate Jacob Michels and Agricultural economist John Beghin delves into the question of whether global estimates of food insecure populations need a reevaluation of their methodology to account for increasing sedentarism. This reevaluation is prompted by the increasing prevalence of sedentary lifestyles worldwide, which calls for a redefinition of caloric thresholds indicating the onset of food insecurity. In this short article, we provide a nontechnical summary of their investigation recently published in Michels and Beghin (2024).

High-Fat Diet Feeding Exacerbates Hiv-1 Rectal Transmission, Saroj Chandra Lohani, Amanda E. Ramer-Tait, Qingsheng Li

Department of Food Science and Technology: Faculty Publications

High-fat diet (HFD) is well known to impact various aspects of gut health and has been associated with many diseases and inflammation. However, the impact of HFD feeding on HIV-1 rectal transmission has not yet been well addressed. With an increasing threat of HIV-1 infection in men who have sex with men (MSM), where the rectal route is the primary mode of infection, it is imperative to understand the impact of HFD on gut microbiota and inflammation and consequently, its effect on HIV-1 rectal transmission. Here, we utilized our double humanized bone marrow, liver, thymus (dHu-BLT) mouse model to assess …

Experimental Sars-Cov-2 Infection Of Elk And Mule Deer, Stephanie M. Porter, Airn E. Hartwig, Helle Bielefeldt-Ohmann, Jeffrey M. Marano, J. Jeffrey Root, Angela M. Bosco-Lauth

United States Department of Agriculture Wildlife Services: Staff Publications

To assess the susceptibility of elk (Cervus canadensis) and mule deer (Odocoileus hemionus) to SARS-CoV-2, we performed experimental infections in both species. Elk did not shed infectious virus but mounted low-level serologic responses. Mule deer shed and transmitted virus and mounted pronounced serologic responses and thus could play a role in SARS-CoV-2 epidemiology.

Perspective Of Us Farmers On Collaborative On-Farm Agronomic Research, Carlos B. Pires, Fernanda S. Krupek, Gabriela I. Carmona, Osler A. Ortez, Laura Thompson, Daniel J. Quinn, Andre F. B. Reis, Rodrigo Werle, Péter Kovács, Maninder P. Singh, J. M. Shawn Hutchinson, Dorivar Ruiz Diaz, Charles W. Rice, Ignacio A. Ciampitti

Nebraska Cooperative Extension: Faculty and Staff Publications

On-farm research has emerged in recent years as a unique approach to involve farmers and other agricultural stakeholders as active participants in knowledge development and as an effective method of technology and innovation transfer across farms. This study assessed the perspective and knowledge of US farmers regarding on-farm research via the implementation of a 24-question survey distributed across most of the US Midwest and South-Central regions.We found that farmers generally are willing to engage with universities to conduct on-farm research and were 40% more likely to adopt practices supported by on-farm research findings than research not conducted on-farm. Notably, a …

The Casnr L.I.N.K.S. Newsletter: Learning Innovation Network For K-12 Schools, Volume 3, Edition 2, February 2024, Bailey Feit, Tammy Mittelstet

CASNR L.I.N.K.S. Newsletter

The purpose of this L.I.N.K.S. newsletter is to provide a monthly update of opportunities and resources for K-12 schools to connect with the University of Nebraska's CASNR Food, Energy, Water, and Societal Systems (FEWS²) programs and partners.

Included in this edition:

K-12 curriculum and resources and upcoming events

Career explorations: pathways for students

Teacher and student opportunities

CASNR Ag Tech Day

Data Driven 4-H statistics field day

2024 Summer Soybean Institute

UNL CASNER six interest areas

School of Natural Resources

Department of Agronomy and Horticulture

Environmental stewards spotlight

Seed Your Future Green Career Week

Cultivando Caminos

Kudos to our partners …

Parallels Of Quantum Superposition In Ecological Models: From Counterintuitive Patterns To Eco-Evolutionary Interpretations Of Cryptic Species, David G. Angeler, Hannah B. Fried-Petersen

School of Natural Resources: Faculty Publications

Background Superposition, i.e. the ability of a particle (electron, photon) to occur in different states or positions simultaneously, is a hallmark in the subatomic world of quantum mechanics. Although counterintuitive at first sight, the quantum world has potential to inform macro-systems of people and nature. Using time series and spatial analysis of bird, phytoplankton and benthic invertebrate communities, this paper shows that superposition can occur analogously in redundancy analysis (RDA) frequently used by ecologists.

Results We show that within individual ecosystems single species can be associated simultaneously with different orthogonal axes in RDA models, which suggests that they operate in …

Immune Profiling In Puerto Rican Injection Drug Users With And Without Hiv-1 Infection, Sydney J. Bennett, Carmen Ana Davila, Zahiraliz Reyes, Aníbal Valentín-Acevedo, Kim Gocchi Carrasco, Roberto Abadie, M. Caleb Marlin, Marci Beel, Andrew G. Chapple, Samodha C. Fernando, Joel M. Guthridge, Kathy S. Chiou, Kirk Kirk, John T. West, Charles Wood

Department of Sociology: Faculty Publications

Antiretroviral therapy has been effective in suppressing HIV viral load and enabling people living with HIV to experience longer, more conventional lives. However, as people living with HIV are living longer, they are developing aging-related diseases prematurely and are more susceptible to comorbidities that have been linked to chronic inflammation. Coincident with HIV infection and aging, drug abuse has also been independently associated with gut dysbiosis, microbial translocation, and inflammation. Here, we hypothesized that injection drug use would exacerbate HIV-induced immune activation and inflammation, thereby intensifying immune dysfunction. We recruited 50 individuals not using injection drugs (36/50 HIV⁺) …

Influence Of Microbes In Mediating Sorghum Resistance To Sugarcane Aphids, Edith Ikuze, Stephanie Cromwell, Paul A. Ayayee, Joe Louis

Department of Entomology: Faculty Publications

Gut microbiomes profoundly influence insect health and mediate interactions between plant hosts and their environments. Insects, including aphids, harbour diverse obligate symbionts that synthesize essential nutrients and facultative symbionts that enhance host fitness in specific ecological contexts. Sorghum (Sorghum bicolor) is a significant cereal crop cultivated worldwide that has been negatively affected by the presence of an invasive piercing-sucking insect pest, the sugarcane aphid (SCA; Melanaphis sacchari). We previously identified SC265 and SC1345 as the resistant and susceptible sorghum lines, respectively, among the founder nested association mapping (NAM) population. Here, using these resistant and susceptible lines, we …

Investigation Into Cardiacmyhc-Α 334–352-Specific Tcr Transgenic Mice Reveals A Role For Cytotoxic Cd4 T Cells In The Development Of Cardiac Autoimmunity, Meghna Sur, Mahima T. Rasquinha, Kiruthiga Mone, Chandirasegaran Massilamany, Ninaad Lasrado, Channabasavaiah B. Gurumurthy, Raymond A. Sobel, Jay Reddy

Jay Reddy Publications

Myocarditis is one of the major causes of heart failure in children and young adults and can lead to dilated cardiomyopathy. Lymphocytic myocarditis could result from autoreactive CD4+ and CD8+ T cells, but defining antigen specificity in disease pathogenesis is challenging. To address this issue, we generated T cell receptor (TCR) transgenic (Tg) C57BL/6J mice specific to cardiac myosin heavy chain (Myhc)-α 334–352 and found that Myhc-α-specific TCRs were expressed in both CD4⁺ and CD8⁺ T cells. To investigate if the phenotype is more pronounced in a myocarditis-susceptible genetic background, we backcrossed with A/J mice. At the fourth …

A Good Idea: Analyzing The Ineffective Enforcement Of Idea Due To Limitations On The Recovery Of Attorneys’ Fees, Anna Anderson

Nebraska Law Bulletin (Selected Issues)

Recovering attorneys’ fees must be limited to some degree, but excessive limitations make enforcing a child’s rights under IDEA more difficult and inaccessible. Where necessary, limitations should be sensible, consistent, and clear to parents and school districts. Further, limitations should encourage efficient resolution, not prolonging the conflict or discouraging alternate dispute resolution. Courts should interpret issues relating to attorneys’ fee recovery favorably to prevailing parties and remain mindful of the goals IDEA seeks to accomplish. Expanding the ability to recover attorneys’ fees will support parents when they advocate for their child’s right under IDEA and, therefore, best support the policy …

Emerging Roles Of Cullin-Ring Ubiquitin Ligases In Cardiac Development, Josue Zambrano-Carrasco, Jianqiu Zou, Wenjuan Wang, Xinghui Sun, Jie Li, Huabo Su

Department of Biochemistry: Faculty Publications

Heart development is a spatiotemporally regulated process that extends from the embryonic phase to postnatal stages. Disruption of this highly orchestrated process can lead to congenital heart disease or predispose the heart to cardiomyopathy or heart failure. Consequently, gaining an in-depth understanding of the molecular mechanisms governing cardiac development holds considerable promise for the development of innovative therapies for various cardiac ailments. While significant progress in uncovering novel transcriptional and epigenetic regulators of heart development has been made, the exploration of post-translational mechanisms that influence this process has lagged. Culling-RING E3 ubiquitin ligases (CRLs), the largest family of ubiquitin ligases, …

High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge As Inhibitors Of Plasmodium Falciparum, Sandra Johannsen, Robin M. Gierse, Arne KrüGer, Rachel L. Edwards, Vittoria Nanna, Anna Fontana, Di Zhu, Tiziana Masini, Lais Pessanha De Carvalho, Mael Poizat, Bart Kieftenbelt, Dana M. Hodge, Sophie University Of Nebraska-Lincoln,, Daan Bunt, Antoine Lacour, Atanaz Shams, Kamila Anna Meissner, Edmarcia Elisa De Souza, Melloney Dröge, Bernard Van Vliet, Jack Den Hartog, Michael C. Hutter, Jana Held, Audrey R. Odom John, Carsten Wrenger, Anna K.H. Hirsch

Department of Agronomy and Horticulture: Faculty Publications

In this study, we identified three novel compound classes with potent activity against Plasmodium falciparum, the most dangerous human malarial parasite. Resistance of this pathogen to known drugs is increasing, and compounds with different modes of action are urgently needed. One promising drug target is the enzyme 1-deoxy-D-xylulose-5- phosphate synthase (DXPS) of the methylerythritol 4-phosphate (MEP) pathway for which we have previously identified three active compound classes against Mycobacterium tuberculosis. The close structural similarities of the active sites of the DXPS enzymes of P. falciparum and M. tuberculosis prompted investigation of their antiparasitic action, all classes …

Multivalent Epigraph Hemagglutinin Vaccine Protects Against Influenza B Virus In Mice, Erika M. Petro-Turnquist, Brigette Corder Kampfe, Amber Gadeken, Matthew J. Pekarek, Eric A. Weaver

Nebraska Center for Virology: Faculty Publications

Influenza B virus is a respiratory pathogen that contributes to seasonal epidemics, accounts for approximately 25% of global influenza infections, and can induce severe disease in young children. While vaccination is the most commonly used method of preventing influenza infections, current vaccines only induce strain-specific responses and have suboptimal efficacy when mismatched from circulating strains. Further, two influenza B virus lineages have been described, B/Yamagatalike and B/Victoria-like, and the limited cross-reactivity between the two lineages provides an additional barrier in developing a universal influenza B virus vaccine. Here, we report a novel multivalent vaccine using computationally designed Epigraph hemagglutinin proteins …

Characterization Of Variant Rnas Encapsidated During Bromovirus Infection By High-Throughput Sequencing, Sarah Dexheimer, Nipin Shrestha, Bandana Sharma Chapagain, Jozef J. Bujarski, Yanbin Yin

Food for Health: Publications

Previously, we described the RNA recombinants accumulating in tissues infected with the bromoviruses BMV (Brome mosaic virus) and CCMV (Cowpea chlorotic mottle virus). In this work, we characterize the recombinants encapsidated inside the purified virion particles of BMV and CCMV. By using a tool called the Viral Recombination Mapper (ViReMa) that detects recombination junctions, we analyzed a high number of high-throughput sequencing (HTS) short RNA sequence reads. Over 28% of BMV or CCMV RNA reads did not perfectly map to the viral genomes. ViReMa identified 1.40% and 1.83% of these unmapped reads as the RNA recombinants, respectively, in BMV and …

Impacts Of Farrowing Pen Design, Season, And Sow Parity On Litter Performance And Piglet Mortality, Verônica Madeira Pacheco, Tami M. Brown-Bandl, Gary A. Rohrer, Rafael Vieira De Sousa, Luciane Silva Martello

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Piglet mortality during lactation is a significant concern in swine production, influenced by complex interactions involving sow, piglet, environmental, and management factors. While crushing by the sow may be the ultimate cause of piglet mortality, there are many factors influencing the outcome, including parity, thermal stress, and animal housing systems. New farrowing systems are continuously being developed; however, it is difficult for producers to make decisions without any scientific basis. This study aimed to assess the impact of different farrowing pen layouts on piglet performance, considering parity and season. A total of 546 sows and 9123 piglets were monitored across …

Implantation Of A Capsular Tension Ring During Cataract Surgery Attenuates Predicted Remodeling Of The Post-Surgical Lens Capsule Along The Visual Axis, Kurt A. Ameku, Caleb C. Berggren, Ryan M. Pedrigi

Department of Mechanical and Materials Engineering: Faculty Publications

Introduction: Cataract surgery permanently alters the mechanical environment of the lens capsule by placing a hole in the anterior portion and implanting an intraocular lens (IOL) that has a very different geometry from the native lens. We hypothesized that implant configuration and mechanical interactions with the post-surgical lens capsule play a key role in determining long-term fibrotic remodeling.

Methods: We developed the first finite element-growth and remodeling (FE-G&R) model of the post-surgical lens capsule to evaluate how implantation of an IOL with and without a capsular tension ring (CTR) impacted evolving lens capsule mechanics and associated fibrosis over …

Program Requirements For Beef Cattle Certified As Usda Organic, Carsten Loseke, Elliott James Dennis

Cornhusker Economics

This document provides an overview of the use and production of the USDA Certified Organic program for the beef cattle industry, with an emphasis on the state of Nebraska. We detail what cattle qualify, feed requirements, medical and health standards of cattle, and premiums paid by consumers for USDA certified organic products. All information is taken from the Organic Foods Production Act Provisions available in the Federal Register.

Biographical Memoirs: Napoleon A. Chagnon, Raymond B. Hames

Department of Anthropology: Faculty Publications

Napoleon A. Chagnon (August 27, 1938–September 21, 2019), elected to the National Academy of Science in 2012. A Biographical Memoir by Raymond B. Hames, University of Nebraska-Lincoln.

Chagnon was a Renaissance anthropologist who made numerous fundamental contributions to anthropology. His films and ethnography have been viewed by millions around the world. He combined a humanistic eye in research with an unwavering scientific approach to human culture and behavior. He set multiple standards for long-term field research in terms of methodological rigor and refinement. He made some of the first tests of inclusive fitness theory in human behavior. And he was …

Gene Editing Of Pigs To Control Influenza A Virus Infections, Taeyong Kwon, Bianca L. Artiaga, Chester D. Mcdowell, Kristin M. Whitworth, Kevin D. Wells, Randall S. Prather, Gustavo Delhon, Mark Cigan, Stephen N. White, Jamie Retallick, Natasha N. Gaudreault, Igor Morozov, Juergen A. Richt

School of Veterinary and Biomedical Sciences: Faculty Publications

Proteolytic activation of the hemagglutinin (HA) glycoprotein by host cellular proteases is pivotal for influenza A virus (IAV) infectivity. Highly pathogenic avian influenza viruses possess the multibasic cleavage site of the HA which is cleaved by ubiquitous proteases, such as furin; in contrast, the monobasic HA motif is recognized and activated by trypsin-like proteases, such as the transmembrane serine protease 2 (TMPRSS2). Here, we aimed to determine the effects of TMPRSS2 on the replication of pandemic H1N1 and H3N2 subtype IAVs in the natural host, the pig. The use of the CRISPR/Cas 9 system led to the establishment of homozygous …