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Analysis Of Legacy Gravity Data Reveals Sediment-Filled Troughs Buried Under Flathead Valley, Montana, Usa, Ali Gebril, Mohamed A. Khalil, Robert Matthew Joeckel, James Rose Feb 2024

Analysis Of Legacy Gravity Data Reveals Sediment-Filled Troughs Buried Under Flathead Valley, Montana, Usa, Ali Gebril, Mohamed A. Khalil, Robert Matthew Joeckel, James Rose

Conservation and Survey Division: Faculty and Staff Publications

Shallow, dominantly silt- and clay-filled erosional troughs in Quaternary sediments under the Flathead Valley (northwestern Montana, USA) are very likely to be hydraulic barriers limiting the horizontal flow of groundwater. Accurately mapping them is important because of increasing demand for groundwater.We used a legacy Bouguer gravity map measured in 1968. The directional derivatives of the map are computed, and the map was enhanced by implementing edge detection tools.We produced generalized derivative, maximum horizontal gradient, total gradient and tilt gradient maps through two-dimensional Fourier transform analysis. These maps were remarkably successful in locating buried troughs in the northern and northwestern parts …


Copper−Cystine Biohybrid-Embedded Nanofiber Aerogels Show Antibacterial And Angiogenic Properties, Anik Karan, Navatha S. Polavaram, Margarita Darder, Yajuan Su, Syed Muntazir Andrabi, S M Shatil Shahriar, Johnson V. John, Zeyu Luo, Mark A. Decoster, Yu Shrike Zhang, Jingwei Xie Feb 2024

Copper−Cystine Biohybrid-Embedded Nanofiber Aerogels Show Antibacterial And Angiogenic Properties, Anik Karan, Navatha S. Polavaram, Margarita Darder, Yajuan Su, Syed Muntazir Andrabi, S M Shatil Shahriar, Johnson V. John, Zeyu Luo, Mark A. Decoster, Yu Shrike Zhang, Jingwei Xie

Department of Mechanical and Materials Engineering: Faculty Publications

Copper−cystine-based high aspect ratio structures (CuHARS) possess exceptional physical and chemical properties and exhibit remarkable biodegradability in human physiological conditions. Extensive testing has confirmed the biocompatibility and biodegradability of CuHARS under diverse biological conditions, making them a viable source of essential Cu2+. These ions are vital for catalyzing the production of nitric oxide (NO) from the decomposition of Snitrosothiols (RSNOs) found in human blood. The ability of CuHARS to act as a Cu2+ donor under specific concentrations has been demonstrated in this study, resulting in the generation of elevated levels of NO. Consequently, this dual function makes …


Taxonomic Notes On The Cladodinae, Lampyrinae, And Lampyrinae/Lampyridae Incertae Sedis (Coleoptera: Lampyridae), Oliver Keller, Gavin J. Martin Feb 2024

Taxonomic Notes On The Cladodinae, Lampyrinae, And Lampyrinae/Lampyridae Incertae Sedis (Coleoptera: Lampyridae), Oliver Keller, Gavin J. Martin

Insecta Mundi

We propose several nomenclatural changes for taxa in the subfamily Cladodinae and the lampyrid tribes Cratomorphini, Lamprocerini, Lampyrini, Photinini, and Pleotomini in the subfamily Lampyrinae (Coleoptera: Lampyridae). We present evidence for the correct year of description of Calotrachelum flavolineatum Pic, 1941, Diaphanes lateapicalis breveapicalis Pic, 1954, Photinus conradti Pic, 1940, and all species described by Charles Émile Blanchard. Spellings are corrected for Diaphanes lateapicalis breveapicalis Pic, 1954, Diaphanes latipennis dartevillei Pic, 1952, Diaphanes longecarinatus Pic, 1955, Diaphanes moultoni latemarginatus Pic, 1938, Lampyris olivieriana von Heyden, 1890, and Photinus reductemarginalis Pic, 1941. We propose Lucidota puertoestrellaensis Keller and Martin nomen novum …


Blood Lead, Cadmium And Hair Mercury Concentrations And Association With Soil, Dust And Occupational Factors In E-Waste Recycling Workers In Bangladesh, Sarker Masud Parvez, Farjana Jahan, Jaynal Abedin, Mahbubur Rahman, Shaikh Sharif Hasan, Nafisa Islam, Nirupam Aich, Mohammad Moniruzzaman, Zahir Islam, Masatake Fujimura, Rubhana Raqib, Luke D. Knibbs, Peter D. Sly Feb 2024

Blood Lead, Cadmium And Hair Mercury Concentrations And Association With Soil, Dust And Occupational Factors In E-Waste Recycling Workers In Bangladesh, Sarker Masud Parvez, Farjana Jahan, Jaynal Abedin, Mahbubur Rahman, Shaikh Sharif Hasan, Nafisa Islam, Nirupam Aich, Mohammad Moniruzzaman, Zahir Islam, Masatake Fujimura, Rubhana Raqib, Luke D. Knibbs, Peter D. Sly

Department of Civil and Environmental Engineering: Faculty Publications

Background: Electronic waste (e-waste) recycling activities release toxic metals, which pose substantial hazard to the environment and human health. We evaluated metal concentrations in biological and environmental samples, and examined the associations between biological lead (Pb), cadmium (Cd), and mercury (Hg) with soil and dust metals, and other possible determinants, among populations exposed and non-exposed to e-waste in Bangladesh.

Methods: A total of 199 e-waste workers and 104 non-exposed individuals were recruited. We measured blood Pb (BPb) and Cd (BCd) concentrations and total Hg (THg) from hair samples. Data were collected on occupational, and behavioral factors. We fitted …


Disruption Of The Sorghum Circadian Clock Impacts Sorghum-Sugarcane Aphid Interaction Dynamics And Aphid Feeding Behavior, Kumar Shrestha, Prince Zogli, Lise Pingault, Sajjan Grover, Juan Betancurt Cardona, Joe Louis Feb 2024

Disruption Of The Sorghum Circadian Clock Impacts Sorghum-Sugarcane Aphid Interaction Dynamics And Aphid Feeding Behavior, Kumar Shrestha, Prince Zogli, Lise Pingault, Sajjan Grover, Juan Betancurt Cardona, Joe Louis

Department of Entomology: Faculty Publications

Circadian clocks play a pivotal role in orchestrating metabolic rhythms in response to environmental stress. Sorghum bicolor (sorghum), a multipurpose cereal crop, suffers severe growth and yield reduction due to feeding by sugarcane aphids (SCA; Melanaphis sacchari), which are phloem-feeding pests. Previously, it has been shown that sorghum utilizes a multitude of defense mechanisms to curb SCA colonization. However, our understanding of the impact of circadian clock on sorghum-aphid interaction dynamics is limited. To explore this, a time-series transcriptomics was conducted on sorghum plants in disrupted circadian rhythm with and without SCA infestation. Transcriptomic analysis revealed a total of …


3d Learning Spaces For Second Language Learning, Emma Olson Feb 2024

3d Learning Spaces For Second Language Learning, Emma Olson

Honors Program: Senior Projects (Public)

Many language teaching techniques and approaches have been used and adapted to culminate in the development of Communicative Language Teaching, which focuses on developing functional proficiency and communicative competence. 3D learning spaces are becoming increasingly more popular for language learning as well, and more specifically, socially-based virtual worlds (or “metaverses”) make good educational tools for developing communicative competence, as they engage learners in situational and experiential learning through increasing authenticity, lowering anxiety levels (i.e., affective filters), and allowing for the development of tools that can support both structured and spontaneous speaking opportunities. After a brief literature review, this thesis therefore …


The 10,000-Year Biocultural History Of Fallow Deer And Its Implications For Conservation Policy, Karis H. Baker, Holly Miller, Sean Doherty, Howard W. I. Gray, Julie Daujat, Çakırlard Çakırlar, Nikolai Spassov, Katerina Trantalidou, Richard Madgwick, Angela L. Lamb, Carly Ameen, Levent Atici, Polydora Baker, Fiona Beglane, Helene Benkert, Robin Bendrey, Annelise Binois-Roman, Ruth F. Carden, Antonio Curci, Bea De Cupere, Cleia Detry, Erika Gál, Chloé Genies, Günther K. Kunst, Robert Liddiard, Rebecca Nicholson, Rossana Villa-Rojas, Joris Peters, Fabienne Pigière, Aleksander G. Pluskowski, Peta Sadler, Sandra Sicard, Lena Strid, Jack Sudds, Robert Symmons, Katie Tardio, Alejandro Valenzuela, Monique Van Veen, Sonja Vuković, Jaco Weinstock, Barbara Wilkens, Roger J. A. Wilson, Jane A. Evans, A. Rus Hoelzel, Naomi Sykes Feb 2024

The 10,000-Year Biocultural History Of Fallow Deer And Its Implications For Conservation Policy, Karis H. Baker, Holly Miller, Sean Doherty, Howard W. I. Gray, Julie Daujat, Çakırlard Çakırlar, Nikolai Spassov, Katerina Trantalidou, Richard Madgwick, Angela L. Lamb, Carly Ameen, Levent Atici, Polydora Baker, Fiona Beglane, Helene Benkert, Robin Bendrey, Annelise Binois-Roman, Ruth F. Carden, Antonio Curci, Bea De Cupere, Cleia Detry, Erika Gál, Chloé Genies, Günther K. Kunst, Robert Liddiard, Rebecca Nicholson, Rossana Villa-Rojas, Joris Peters, Fabienne Pigière, Aleksander G. Pluskowski, Peta Sadler, Sandra Sicard, Lena Strid, Jack Sudds, Robert Symmons, Katie Tardio, Alejandro Valenzuela, Monique Van Veen, Sonja Vuković, Jaco Weinstock, Barbara Wilkens, Roger J. A. Wilson, Jane A. Evans, A. Rus Hoelzel, Naomi Sykes

School of Global Integrative Studies: Faculty Publications

Over the last 10,000 y, humans have manipulated fallow deer populations with varying outcomes. Persian fallow deer (Dama mesopotamica) are now endangered. European fallow deer (Dama dama) are globally widespread and are simultaneously considered wild, domestic, endangered, invasive and are even the national animal of Barbuda and Antigua. Despite their close association with people, there is no consensus regarding their natural ranges or the timing and circumstances of their human-mediated translocations and extirpations. Our mitochondrial analyses of modern and archaeological specimens revealed two distinct clades of European fallow deer present in Anatolia and the Balkans. Zooarchaeological evidence …


Charting Early Trajectories Of Executive Control With The Shape School, Caron A. C. Clark, Tiffany D. Sheffield, Nicolas Chevalier, Jennifer Mize Nelson, Sandra A. Wiebe, Kimberly Andrews Espy Feb 2024

Charting Early Trajectories Of Executive Control With The Shape School, Caron A. C. Clark, Tiffany D. Sheffield, Nicolas Chevalier, Jennifer Mize Nelson, Sandra A. Wiebe, Kimberly Andrews Espy

Department of Psychology: Faculty Publications

Despite acknowledgement of the importance of executive control for learning and behavior, there is a dearth of research charting its developmental trajectory as it unfolds against the background of children’s sociofamilial milieus. Using a prospective, cohort-sequential design, this study describes growth trajectories for inhibitory control and cognitive flexibility across the preschool period in relation to child sex and sociofamilial resources. At ages 3, 3.75, 4.5, and 5.25 years, children (N = 388) from a broad range of social backgrounds were assessed using the Shape School, a graduated measure of executive control incorporating baseline, inhibitory control, and cognitive flexibility conditions. …


United States National Science Foundation (Nsf) Scientific Integrity Policy Feb 2024

United States National Science Foundation (Nsf) Scientific Integrity Policy

Copyright, Fair Use, Scholarly Communication, etc.

United States National Science Foundation (NSF) Scientific Integrity Policy


The Impact Of Social Exclusion On Anticipatory Attentional Processing, John E. Kiat, Jacob E. Cheadle, Bridget J. Goosby Feb 2024

The Impact Of Social Exclusion On Anticipatory Attentional Processing, John E. Kiat, Jacob E. Cheadle, Bridget J. Goosby

Department of Sociology: Faculty Publications

The importance of understanding how we anticipate and prepare for social rejection is underscored by the mental and physical toll of continual social vigilance. In this study, we investigate the impact of social rejection on anticipatory attentional processes using the well-known Cyberball task, a paradigm in which participants engage in a game of catch with virtual avatars who after an initial period of fair-play (inclusion condition) then exclude the participant from the game (exclusion condition). The degree of anticipatory attention allocated by subjects towards the avatars was assessed by measuring P3b responses towards the avatars’ preparatory actions (i.e. the phase …


Factors Associated With Gaps In Naloxone Knowledge: Evidence From A 2022 Great Plains Survey, Spencer Cooper‑Ohm, Patrick Habecker, Ryan Humeniuk, Rick A. Bevins Feb 2024

Factors Associated With Gaps In Naloxone Knowledge: Evidence From A 2022 Great Plains Survey, Spencer Cooper‑Ohm, Patrick Habecker, Ryan Humeniuk, Rick A. Bevins

Department of Sociology: Faculty Publications

Background The rising prevalence of fast-acting opioids in the USA suggests the increased need for non-professional first responder administration of naloxone. Effective administration of naloxone during an overdose requires that bystanders are familiar with, have access to, and know how to use naloxone.

Methods Drawing on a statewide, address-based sample of Nebraskan adults, we used logistic regression to predict the likelihood of respondents’ familiarity with, access to, and competency to administer naloxone. Our independent variables included measures indicating proximity to drug use, perceived community stigma toward people who use drugs, and demographic data.

Results There were significant gaps in naloxone …


Discussion On “Spatial+: A Novel Approach To Spatial Confounding” By Dupont, Wood, And Augustin, Brian J. Reich, Shu Yang, Yawen Guan Feb 2024

Discussion On “Spatial+: A Novel Approach To Spatial Confounding” By Dupont, Wood, And Augustin, Brian J. Reich, Shu Yang, Yawen Guan

Department of Statistics: Faculty Publications

Congratulations to the authors for this thoughtful and timely contribution to the spatial confounding literature. The intuitive nature of the method and simplicity of the estimation procedure will surely make Spatial+ popular with practitioners, and the theoretical developments are a major advance for researchers in this area. There is much to discuss! We have formatted our discussion in two sections: in Section 2 we consider the assumptions and statistical properties of Spatial+, and in Section 3 we examine how Spatial+ fits in the wider literature on spatial causal inference.


Prebiotic Proanthocyanidins Inhibit Bile Reflux–Induced Esophageal Adenocarcinoma Through Reshaping The Gut Microbiome And Esophageal Metabolome, Katherine M. Weh, Connor L. Howard, Yun Zhang, Bridget A. Tripp, Jennifer Clarke, Amy B. Howell, Joel H. Rubenstein, Julian A. Abrams, Maria Westerhoff, Laura A. Kresty Feb 2024

Prebiotic Proanthocyanidins Inhibit Bile Reflux–Induced Esophageal Adenocarcinoma Through Reshaping The Gut Microbiome And Esophageal Metabolome, Katherine M. Weh, Connor L. Howard, Yun Zhang, Bridget A. Tripp, Jennifer Clarke, Amy B. Howell, Joel H. Rubenstein, Julian A. Abrams, Maria Westerhoff, Laura A. Kresty

Department of Statistics: Faculty Publications

The gut and local esophageal microbiome progressively shift from healthy commensal bacteria to inflammation-linked pathogenic bacteria in patients with gastroesophageal reflux disease, Barrett’s esophagus, and esophageal adenocarcinoma (EAC). However, mechanisms by which microbial communities and metabolites contribute to reflux-driven EAC remain incompletely understood and challenging to target. Herein, we utilized a rat reflux-induced EAC model to investigate targeting the gut microbiome–esophageal metabolome axis with cranberry proanthocyanidins (C-PAC) to inhibit EAC progression. Sprague-Dawley rats, with or without reflux induction, received water or C-PAC ad libitum (700 μg/rat/day) for 25 or 40 weeks. C-PAC exerted prebiotic activity abrogating reflux-induced dysbiosis and mitigating …


Command Injection Attacks In Smart Grids: A Survey, Muhammad Usama, Muhammad Naveed Aman Feb 2024

Command Injection Attacks In Smart Grids: A Survey, Muhammad Usama, Muhammad Naveed Aman

School of Computing: Faculty Publications

Cybersecurity is important in the realization of various smart grid technologies. Several studies have been conducted to discuss different types of cyberattacks and provide their countermeasures. The false command injection attack (FCIA) is considered one of the most critical attacks that have been studied. Various techniques have been proposed in the literature to detect FCIAs on different components of smart grids. The predominant focus of current surveys lies on FCIAs and detection techniques for such attacks. This article presents a survey of existing works on FCIAs and classifies FCIAs in smart grids according to the targeted component. The impacts of …


Reducing Loneliness And Improving Social Support Among Older Adults Through Different Modalities Of Personal Voice Assistants, Valerie Jones, Changmin Yan, Marcia Shade, Julie Blaskewicz Boron, Zhengxu Yan, Hyeon Jung Heselton, Kate Johnson, Victoria Dube Feb 2024

Reducing Loneliness And Improving Social Support Among Older Adults Through Different Modalities Of Personal Voice Assistants, Valerie Jones, Changmin Yan, Marcia Shade, Julie Blaskewicz Boron, Zhengxu Yan, Hyeon Jung Heselton, Kate Johnson, Victoria Dube

College of Journalism and Mass Communications: Faculty Publications

This study examines the potential of AI-powered personal voice assistants (PVAs) in reducing loneliness and increasing social support among older adults. With the aging population rapidly expanding, innovative solutions are essential. Prior research has indicated the effectiveness of various interactive communication technologies (ICTs) in mitigating loneliness, but studies focusing on PVAs, particularly considering their modality (audio vs. video), are limited. This research aims to fill this gap by evaluating how voice assistants, in both audio and video formats, influence perceived loneliness and social support. This study examined the impact of voice assistant technology (VAT) interventions, both audio-based (A-VAT) and video-based …


Predicting Sedentarism And Its Impact On Caloric Requirements, Jacob Michels, John C. Beghin Feb 2024

Predicting Sedentarism And Its Impact On Caloric Requirements, Jacob Michels, John C. Beghin

Yeutter Institute International Trade Policy Review

A recent study conducted by PhD candidate Jacob Michels and Agricultural economist John Beghin delves into the question of whether global estimates of food insecure populations need a reevaluation of their methodology to account for increasing sedentarism. This reevaluation is prompted by the increasing prevalence of sedentary lifestyles worldwide, which calls for a redefinition of caloric thresholds indicating the onset of food insecurity. In this short article, we provide a nontechnical summary of their investigation recently published in Michels and Beghin (2024).


High-Fat Diet Feeding Exacerbates Hiv-1 Rectal Transmission, Saroj Chandra Lohani, Amanda E. Ramer-Tait, Qingsheng Li Feb 2024

High-Fat Diet Feeding Exacerbates Hiv-1 Rectal Transmission, Saroj Chandra Lohani, Amanda E. Ramer-Tait, Qingsheng Li

Department of Food Science and Technology: Faculty Publications

High-fat diet (HFD) is well known to impact various aspects of gut health and has been associated with many diseases and inflammation. However, the impact of HFD feeding on HIV-1 rectal transmission has not yet been well addressed. With an increasing threat of HIV-1 infection in men who have sex with men (MSM), where the rectal route is the primary mode of infection, it is imperative to understand the impact of HFD on gut microbiota and inflammation and consequently, its effect on HIV-1 rectal transmission. Here, we utilized our double humanized bone marrow, liver, thymus (dHu-BLT) mouse model to assess …


The Use And Impact Of Strategic Planning In Nebraska Public Schools, Jodi A. Frager Feb 2024

The Use And Impact Of Strategic Planning In Nebraska Public Schools, Jodi A. Frager

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

In the landscape of modern education, the role of a superintendent has become increasingly complex, marked by demands for higher student achievement and round-the-clock communication. This complexity, underscored by technological advancements and evolving accountability measures, underscores the criticality of strategic planning for school districts. This dissertation aims to explore the relationship between superintendent engagement with strategic planning and student outcomes, particularly focusing on high school graduation rates and ACT scores in Nebraska public schools. Drawing on theoretical frameworks such as Systems Theory, the study employs a quantitative approach, utilizing surveys administered to superintendents alongside publicly available archival data on graduation …


Parallels Of Quantum Superposition In Ecological Models: From Counterintuitive Patterns To Eco-Evolutionary Interpretations Of Cryptic Species, David G. Angeler, Hannah B. Fried-Petersen Jan 2024

Parallels Of Quantum Superposition In Ecological Models: From Counterintuitive Patterns To Eco-Evolutionary Interpretations Of Cryptic Species, David G. Angeler, Hannah B. Fried-Petersen

School of Natural Resources: Faculty Publications

Background Superposition, i.e. the ability of a particle (electron, photon) to occur in different states or positions simultaneously, is a hallmark in the subatomic world of quantum mechanics. Although counterintuitive at first sight, the quantum world has potential to inform macro-systems of people and nature. Using time series and spatial analysis of bird, phytoplankton and benthic invertebrate communities, this paper shows that superposition can occur analogously in redundancy analysis (RDA) frequently used by ecologists.

Results We show that within individual ecosystems single species can be associated simultaneously with different orthogonal axes in RDA models, which suggests that they operate in …


Factors Affecting Walleye And Sauger Recruitment In Lewis And Clark Lake, South Dakota, 2001–2022, William J. Radigan, Phil Chvala, Christopher Longhenry, Mark A. Pegg Jan 2024

Factors Affecting Walleye And Sauger Recruitment In Lewis And Clark Lake, South Dakota, 2001–2022, William J. Radigan, Phil Chvala, Christopher Longhenry, Mark A. Pegg

School of Natural Resources: Faculty Publications

Abundance of adult walleye (Sander vitreus) and sauger (Sander canadensis), two important sport fishes, decreased significantly during 2001–2022 in Lewis and Clark Lake, a border water between Nebraska and South Dakota, despite walleye fingerling stocking and stable age-0 abundance of both species. We sought to identify factors that drove variation in age-0 abundance from 2001 to 2022 using an information theoretic approach. Age-0 walleye catch per unit effort (CPUE) was correlated to mean monthly outflow, mean annual precipitation, and mean April gauge height in a delta. Age-0 sauger CPUE was correlated to adult conspecific CPUE, mean …


Metabolic Collaboration Between Cells In The Tumor Microenvironment Has A Negligible Effect On Tumor Growth, Johan Gustafsson, Fariba Roshanzamir, Anders Hagnestål, Sagar M. Patel, Oseeyi I. Daudu, Donald F. Becker, Jonathan L. Robinson, Jens Nielsen Jan 2024

Metabolic Collaboration Between Cells In The Tumor Microenvironment Has A Negligible Effect On Tumor Growth, Johan Gustafsson, Fariba Roshanzamir, Anders Hagnestål, Sagar M. Patel, Oseeyi I. Daudu, Donald F. Becker, Jonathan L. Robinson, Jens Nielsen

Department of Biochemistry: Faculty Publications

The tumor microenvironment is composed of a complex mixture of different cell types interacting under conditions of nutrient deprivation, but the metabolism therein is not fully understood due to difficulties in measuring metabolic fluxes and exchange of metabolites between different cell types in vivo. Genome-scale metabolic modeling enables estimation of such exchange fluxes as well as an opportunity to gain insight into the metabolic behavior of individual cell types. Here, we estimated the availability of nutrients and oxygen within the tumor microenvironment using concentration measurements from blood together with a metabolite diffusion model. In addition, we developed an approach …


The Second Digital Transformation Of Scholarly Publishing: Strategic Context And Shared Infrastructure, Tracy Bergstrom, Oya Y. Rieger, Roger C. Schonfeld Jan 2024

The Second Digital Transformation Of Scholarly Publishing: Strategic Context And Shared Infrastructure, Tracy Bergstrom, Oya Y. Rieger, Roger C. Schonfeld

Copyright, Fair Use, Scholarly Communication, etc.

Today, the scholarly publishing sector is undergoing its second digital transformation. The first digital transformation saw a massive shift from paper to digital, but otherwise publishing retained many of the structures, workflows, incentives, and outputs that characterized the print era. A variety of shared infrastructure was developed to serve the needs of this first digital transformation. In this current second digital transformation, many of the structures, workflows, incentives, and outputs that characterized the print era are being revamped in favor of new approaches that bring tremendous opportunities, and also non-trivial risks, to scholarly communication. The second digital transformation requires shared …


Immune Profiling In Puerto Rican Injection Drug Users With And Without Hiv-1 Infection, Sydney J. Bennett, Carmen Ana Davila, Zahiraliz Reyes, Aníbal Valentín-Acevedo, Kim Gocchi Carrasco, Roberto Abadie, M. Caleb Marlin, Marci Beel, Andrew G. Chapple, Samodha C. Fernando, Joel M. Guthridge, Kathy S. Chiou, Kirk Kirk, John T. West, Charles Wood Jan 2024

Immune Profiling In Puerto Rican Injection Drug Users With And Without Hiv-1 Infection, Sydney J. Bennett, Carmen Ana Davila, Zahiraliz Reyes, Aníbal Valentín-Acevedo, Kim Gocchi Carrasco, Roberto Abadie, M. Caleb Marlin, Marci Beel, Andrew G. Chapple, Samodha C. Fernando, Joel M. Guthridge, Kathy S. Chiou, Kirk Kirk, John T. West, Charles Wood

Department of Sociology: Faculty Publications

Antiretroviral therapy has been effective in suppressing HIV viral load and enabling people living with HIV to experience longer, more conventional lives. However, as people living with HIV are living longer, they are developing aging-related diseases prematurely and are more susceptible to comorbidities that have been linked to chronic inflammation. Coincident with HIV infection and aging, drug abuse has also been independently associated with gut dysbiosis, microbial translocation, and inflammation. Here, we hypothesized that injection drug use would exacerbate HIV-induced immune activation and inflammation, thereby intensifying immune dysfunction. We recruited 50 individuals not using injection drugs (36/50 HIV+) …


Intensifying Rice Production To Reduce Imports And Land Conversion In Africa, Shen Yuan, Kazuki Saito, Pepijn A.J. Van Oort, Martin K. Van Ittersum, Shaobing Peng, Patricio Grassini Jan 2024

Intensifying Rice Production To Reduce Imports And Land Conversion In Africa, Shen Yuan, Kazuki Saito, Pepijn A.J. Van Oort, Martin K. Van Ittersum, Shaobing Peng, Patricio Grassini

Department of Agronomy and Horticulture: Faculty Publications

Africa produces around 60% of the rice the continent consumes, relying heavily on rice imports to fulfill the rest of the domestic demand.Over the past 10 years, the rice-agricultural area increased nearly 40%, while average yield remained stagnant. Here we used a process-based crop simulation modelling approach combined with local weather, soil, and management datasets to evaluate the potential to increase rice production on existing cropland area in Africa and assess cropland expansion and rice imports by year 2050 for different scenarios of yield intensification. We find that Africa can avoid further increases in rice imports, and even reduce them, …


High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge As Inhibitors Of Plasmodium Falciparum, Sandra Johannsen, Robin M. Gierse, Arne KrüGer, Rachel L. Edwards, Vittoria Nanna, Anna Fontana, Di Zhu, Tiziana Masini, Lais Pessanha De Carvalho, Mael Poizat, Bart Kieftenbelt, Dana M. Hodge, Sophie University Of Nebraska-Lincoln,, Daan Bunt, Antoine Lacour, Atanaz Shams, Kamila Anna Meissner, Edmarcia Elisa De Souza, Melloney Dröge, Bernard Van Vliet, Jack Den Hartog, Michael C. Hutter, Jana Held, Audrey R. Odom John, Carsten Wrenger, Anna K.H. Hirsch Jan 2024

High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge As Inhibitors Of Plasmodium Falciparum, Sandra Johannsen, Robin M. Gierse, Arne KrüGer, Rachel L. Edwards, Vittoria Nanna, Anna Fontana, Di Zhu, Tiziana Masini, Lais Pessanha De Carvalho, Mael Poizat, Bart Kieftenbelt, Dana M. Hodge, Sophie University Of Nebraska-Lincoln,, Daan Bunt, Antoine Lacour, Atanaz Shams, Kamila Anna Meissner, Edmarcia Elisa De Souza, Melloney Dröge, Bernard Van Vliet, Jack Den Hartog, Michael C. Hutter, Jana Held, Audrey R. Odom John, Carsten Wrenger, Anna K.H. Hirsch

Department of Agronomy and Horticulture: Faculty Publications

In this study, we identified three novel compound classes with potent activity against Plasmodium falciparum, the most dangerous human malarial parasite. Resistance of this pathogen to known drugs is increasing, and compounds with different modes of action are urgently needed. One promising drug target is the enzyme 1-deoxy-D-xylulose-5- phosphate synthase (DXPS) of the methylerythritol 4-phosphate (MEP) pathway for which we have previously identified three active compound classes against Mycobacterium tuberculosis. The close structural similarities of the active sites of the DXPS enzymes of P. falciparum and M. tuberculosis prompted investigation of their antiparasitic action, all classes …


Implantation Of A Capsular Tension Ring During Cataract Surgery Attenuates Predicted Remodeling Of The Post-Surgical Lens Capsule Along The Visual Axis, Kurt A. Ameku, Caleb C. Berggren, Ryan M. Pedrigi Jan 2024

Implantation Of A Capsular Tension Ring During Cataract Surgery Attenuates Predicted Remodeling Of The Post-Surgical Lens Capsule Along The Visual Axis, Kurt A. Ameku, Caleb C. Berggren, Ryan M. Pedrigi

Department of Mechanical and Materials Engineering: Faculty Publications

Introduction: Cataract surgery permanently alters the mechanical environment of the lens capsule by placing a hole in the anterior portion and implanting an intraocular lens (IOL) that has a very different geometry from the native lens. We hypothesized that implant configuration and mechanical interactions with the post-surgical lens capsule play a key role in determining long-term fibrotic remodeling.

Methods: We developed the first finite element-growth and remodeling (FE-G&R) model of the post-surgical lens capsule to evaluate how implantation of an IOL with and without a capsular tension ring (CTR) impacted evolving lens capsule mechanics and associated fibrosis over …


Augusta: From Rna-Seq To Gene Regulatory Networks And Boolean Models, Jana Musilova, Zdenek Vafek, Bhanwar Lal Puniya, Ralf Zimmer, Tomáš Helikar, Karel Sedlar Jan 2024

Augusta: From Rna-Seq To Gene Regulatory Networks And Boolean Models, Jana Musilova, Zdenek Vafek, Bhanwar Lal Puniya, Ralf Zimmer, Tomáš Helikar, Karel Sedlar

Department of Biochemistry: Faculty Publications

Computational models of gene regulations help to understand regulatory mechanisms and are extensively used in a wide range of areas, e.g., biotechnology or medicine, with significant benefits. Unfortunately, there are only a few computational gene regulatory models of whole genomes allowing static and dynamic analysis due to the lack of sophisticated tools for their reconstruction. Here, we describe Augusta, an open-source Python package for Gene Regulatory Network (GRN) and Boolean Network (BN) inference from the high-throughput gene expression data. Augusta can reconstruct genome-wide models suitable for static and dynamic analyses. Augusta uses a unique approach where the first estimation of …


Electron Effective Mass In Gan Revisited: New Insights From Terahertz And Mid-Infrared Optical Hall Effect, Nerijus Armakavicius, Sean Knight, Philipp Kühne, Vallery Stanishev, Dat Q. Tran, Steffen Richter, Alexis Papamichail, Megan Stokey, Preston Sorensen, Ufuk Kilic, Mathias Schubert, Plamen P. Paskov, Vanya Darakchieva Jan 2024

Electron Effective Mass In Gan Revisited: New Insights From Terahertz And Mid-Infrared Optical Hall Effect, Nerijus Armakavicius, Sean Knight, Philipp Kühne, Vallery Stanishev, Dat Q. Tran, Steffen Richter, Alexis Papamichail, Megan Stokey, Preston Sorensen, Ufuk Kilic, Mathias Schubert, Plamen P. Paskov, Vanya Darakchieva

Department of Electrical and Computer Engineering: Faculty Publications

Electron effective mass is a fundamental material parameter defining the free charge carrier transport properties, but it is very challenging to be experimentally determined at high temperatures relevant to device operation. In this work, we obtain the electron effective mass parameters in a Si-doped GaN bulk substrate and epitaxial layers from terahertz (THz) and mid-infrared (MIR) optical Hall effect (OHE) measurements in the temperature range of 38–340 K. The OHE data are analyzed using the well-accepted Drude model to account for the free charge carrier contributions. A strong temperature dependence of the electron effective mass parameter in both bulk and …


Effect Of Dietary Phytase On Water And Fecal Prokaryotic And Eukaryotic Microbiomes In A Hybrid Tilapia (Oreochromis Aureus X O. Niloticus) Mixotrophic Biofloc Production System, Candis L. Ray, Jason Abernathy, Bartholomew Green, Adam Rivers, Kevin Schrader, Steven Rawles, Matthew Mcentire, Miles Lange, Carl Webster Jan 2024

Effect Of Dietary Phytase On Water And Fecal Prokaryotic And Eukaryotic Microbiomes In A Hybrid Tilapia (Oreochromis Aureus X O. Niloticus) Mixotrophic Biofloc Production System, Candis L. Ray, Jason Abernathy, Bartholomew Green, Adam Rivers, Kevin Schrader, Steven Rawles, Matthew Mcentire, Miles Lange, Carl Webster

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

In this study we evaluated feed and temporal effects on prokaryotic (16S) and eukaryotic (18S) microbiome dynamics in an outdoor mixotrophic biofloc system used to grow hybrid tilapia (Oreochromis aureus x O. niloticus) to market size. The dicalcium phosphate -free practical feed treated with 6-phytase (3000 FTU/kg; P-Free+ Phytase) and positive (Control) and negative (P-Free) control practical feeds used were formulated to contain 27.7% digestible protein and 4% lipid. Sex reversed, all-male hybrid tilapia (28.9 g/fish) were stocked (29 fish/m3) in 9 outdoor rectangular tanks (16.6 m3) and grown for 154 days. The …


Opportunities And Challenges Of Generative Ai In Construction Industry: Focusing On Adoption Of Text-Based Models, Prashnna Ghimire, Kyungki Kim, Manoj Acharya Jan 2024

Opportunities And Challenges Of Generative Ai In Construction Industry: Focusing On Adoption Of Text-Based Models, Prashnna Ghimire, Kyungki Kim, Manoj Acharya

Durham School of Architectural Engineering and Construction: Faculty Publications

In the last decade, despite rapid advancements in artificial intelligence (AI) transforming many industry practices, construction largely lags in adoption. Recently, the emergence and rapid adoption of advanced large language models (LLMs) like OpenAI’s GPT, Google’s PaLM, and Meta’s Llama have shown great potential and sparked considerable global interest. However, the current surge lacks a study investigating the opportunities and challenges of implementing Generative AI (GenAI) in the construction sector, creating a critical knowledge gap for researchers and practitioners. This underlines the necessity to explore the prospects and complexities of GenAI integration. Bridging this gap is fundamental to optimizing GenAI’s …