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Unemployment And Opioid-Related Mortality Rates In U.S. Counties: Investigating Social Capital And Social Isolation–Smoking Pathways, Tse-Chuan Yang, Seulki Kim, Stephen A. Matthews May 2023

Unemployment And Opioid-Related Mortality Rates In U.S. Counties: Investigating Social Capital And Social Isolation–Smoking Pathways, Tse-Chuan Yang, Seulki Kim, Stephen A. Matthews

Department of Sociology: Faculty Publications

We examine two mechanisms—social capital and sociobehavior—potentially linking unemployment rates to opioid-related mortality and investigate whether the mechanisms differ geographically by the pace of the opioid crisis. Applying path analysis techniques to 2015–2017 opioid-related mortality in U.S. counties (N = 2,648), we find that (1) high unemployment rates are not directly associated with opioid-related mortality rates; (2) high unemployment rates are negatively associated with social capital, and low social capital contributes to high opioid-related mortality; (3) high unemployment rates increase social isolation and the prevalence of smoking, which is positively related to opioid-related mortality; and (4) the pathways are stronger …


New Species, Synonymies And Transfers In Neotropical Lamiinae (Coleoptera: Cerambycidae), Larry G. Bezark, Antonio Santos-Silva Apr 2023

New Species, Synonymies And Transfers In Neotropical Lamiinae (Coleoptera: Cerambycidae), Larry G. Bezark, Antonio Santos-Silva

Insecta Mundi

Four new species and one new genus of Lamiinae (Coleoptera: Cerambycidae) are described: Nyssodrysilla humeralis new species (Acanthocinini), from Paraguay; Atrypanius schmidi new species (Acan­thocinini), from Paraguay; Chicanatonus hovorei, new genus, new species (Acanthocinini), from Mexico; Euryestola transversa new species (Calliini), from Ecuador. The following new combinations are established: Leiopus convexus Melzer, 1934 is transferred to Hyperplatys Haldeman, 1847; Leiopus floccidus Erichson, 1847 is transferred to Anisopodus White, 1855; Leiopus marcelamonneae Audureau and Demez, 2015 and L. pleuriticus White, 1855 are transferred to Atrypanius Bates, 1864. Leiopus histrionicus Gistel, 1848 is newly synonymized with Eutrypanus dorsalis (Germar, 1823). …


The Rise And Fall Of Daca: An Audio Series, Dulce Garcia Apr 2023

The Rise And Fall Of Daca: An Audio Series, Dulce Garcia

Honors Program: Senior Projects (Public)

The history of Deferred Action for Childhood Arrivals, commonly known as DACA, is a tumultuous one. In 2012, when President Obama created DACA through an executive order it gave relief to hundreds of thousands of people who were brought to the United States as children without their knowledge, giving them a range of benefits like never before including a work permit, a social security number, protection from deportation, and others. Yet, these last ten years the program has stood on shaky grounds with constant court battles canceling, reinstating or partially rolling the program. This audio series will give a deep …


Energy Efficient Integrated Mems Neural Network For Simultaneous Sensing And Computing, Hamed Nikfarjam, Mohammad Megdadi, Mohammad Okour, Siavash Pourkamali, F. M. Alsaleem Apr 2023

Energy Efficient Integrated Mems Neural Network For Simultaneous Sensing And Computing, Hamed Nikfarjam, Mohammad Megdadi, Mohammad Okour, Siavash Pourkamali, F. M. Alsaleem

Durham School of Architectural Engineering and Construction: Faculty Publications

Biological systems seamlessly combine multiple functions in lightweight and energy-efficient structures. Such capability in synthetic structures would be desirable in numerous engineering applications such as aerospace, robotics and wearable devices. Here we report an integrated silicon-based structure configured to sense, perform different classification algorithms, and produce an action signal within the same physical layer. The algorithms are coded in the mechanical responses of the sensing elements of multiple coupled micro-electromechanical systems (MEMS), simultaneously capturing acceleration measurements to produce an actuated signal. This all-in-one structure operates with zero circuitry and low power consumption. As a demonstration, we designed and fabricated a …


Riodinid Butterfly Fauna (Lepidoptera) Of The Cosñipata Region, Peru: Annotated Checklist, Community Structure, And Contrast With Lycaenidae, Gerardo Lamas, Jon D. Turner, Michael L. Mcinnis, Robert K. Robbins Apr 2023

Riodinid Butterfly Fauna (Lepidoptera) Of The Cosñipata Region, Peru: Annotated Checklist, Community Structure, And Contrast With Lycaenidae, Gerardo Lamas, Jon D. Turner, Michael L. Mcinnis, Robert K. Robbins

Insecta Mundi

A team of experienced lepidopterists sampled the butterfly fauna of Peru’s Cosñipata Region from 400 to 4,000 m elevation for more than a decade (7,440 field person-hours) and supplemented this sam­ple with data from museum specimens and the scientific literature. An annotated checklist of Cosñipata Riodinidae (Lepidoptera: Papilionoidea) documents 398 species, which represents 29% of the world Rio­dinidae fauna. For each, it lists sample abundance, adult behavior, elevation, and temporal distribution. In the fieldwork sample, 75 species (20.9%) were sampled once and 39 (9.8%) were not encountered (collected or imaged by others). A riodinid species of median abundance was sampled …


Evaluation Of North American Spider Wasp (Hymenoptera: Pompilidae) Common Names, Frank E. Kurczewski, Rick C. West Apr 2023

Evaluation Of North American Spider Wasp (Hymenoptera: Pompilidae) Common Names, Frank E. Kurczewski, Rick C. West

Insecta Mundi

The use of common names for species and subspecies of North American spider wasps (Hymenop­tera: Pompilidae) presents a variety of questions for pompilid specialists as most pompilid taxa are difficult to identify, even under the microscope. Some common names currently being used for spider wasp species are acceptable while others are misleading, unfit and unacceptable. Opinions on the relative value of common names for spider wasps from current Pompilidae researchers are given in the Introduction. Eleven inappro­priate common names for North American Pompilidae species and subspecies are identified and discussed in the Results.

The use of common names for fish, …


Improving Nasa’S Earth Satellite And Model Data Discoverability For Interdisciplinary Research, Applications, And Education, Zhong Liu, Chung-Lin Shie, Suhung Shen, James Acker, Angela Li, Jennifer C. Wei, David J. Meyer Apr 2023

Improving Nasa’S Earth Satellite And Model Data Discoverability For Interdisciplinary Research, Applications, And Education, Zhong Liu, Chung-Lin Shie, Suhung Shen, James Acker, Angela Li, Jennifer C. Wei, David J. Meyer

Copyright, Fair Use, Scholarly Communication, etc.

Since the Internet era began, numerous earth science data services have been developed to facilitate data discovery (for example, data sources, documents, facts, visualization, opinions) and data access for research and application activities. For example, a large collection of NASA’s earth science data has been made searchable and freely downloadable over the Internet. Some value-added services even allow users to analyze and visualize many variables online (for example, 2,000+ in NASA Giovanni) without downloading data and software.

However, finding and discovering suitable datasets and information for interdisciplinary research (involving two or more scientific disciplines), applications, education, and other emerging activities …


You Never Really Leave, John Kuligowski Apr 2023

You Never Really Leave, John Kuligowski

Department of English: Dissertations, Theses, and Student Research

YOU NEVER REALLY LEAVE is a thesis which consists in a critical introduction that broadly explores my experience of creating a short story collection, as well as the ensuing collection of five short stories. The critical introduction examines the form and content of the following stories, as well as the influences that have been instrumental to my writing. It furnishes details about themes and subject matter which have been consistent in my fiction thus far, and it depicts some of the motivations behind it. The stories themselves range from a realist mode to what has been labeled by other writers …


Entropy And Energy Profiles Of Chemical Reactions, Johannes C. B. Dietschreit, Dennis J. Diestler, Rafael Gómez-Bombarelli Apr 2023

Entropy And Energy Profiles Of Chemical Reactions, Johannes C. B. Dietschreit, Dennis J. Diestler, Rafael Gómez-Bombarelli

Department of Agronomy and Horticulture: Faculty Publications

The description of chemical processes at the molecular level is often facilitated by use of reaction coordinates, or collective variables (CVs). The CV measures the progress of the reaction and allows the construction of profiles that track the evolution of a specific property as the reaction progresses. Whereas CVs are routinely used, especially alongside enhanced sampling techniques, links between profiles and thermodynamic state functions and reaction rate constants are not rigorously exploited. Here, we report a unified treatment of such reaction profiles. Tractable expressions are derived for the free-energy, internal-energy, and entropy profiles as functions of only the CV. We …


Climate-Controlled Submarine Landslides On The Antarctic Continental Margin, Jenny A. Gales, Robert M. Mckay, Laura De Santis, Michele Rebesco, Jan Sverre Laberg, Amelia E. Shevenell, David M. Harwood, R. Mark Leckie, Denise K. Kulhanek, Maxine King, Molly Patterson, Renata G. Lucchi, Sookwan Kim, Sunghan Kim, Justin Dodd, Julia Seidenstein, Catherine Prunella, Giulia M. Ferrante, Iodp Expedition Apr 2023

Climate-Controlled Submarine Landslides On The Antarctic Continental Margin, Jenny A. Gales, Robert M. Mckay, Laura De Santis, Michele Rebesco, Jan Sverre Laberg, Amelia E. Shevenell, David M. Harwood, R. Mark Leckie, Denise K. Kulhanek, Maxine King, Molly Patterson, Renata G. Lucchi, Sookwan Kim, Sunghan Kim, Justin Dodd, Julia Seidenstein, Catherine Prunella, Giulia M. Ferrante, Iodp Expedition

Department of Earth and Atmospheric Sciences: Faculty Publications

Antarctica’s continental margins pose an unknown submarine landslidegenerated tsunami risk to Southern Hemisphere populations and infrastructure. Understanding the factors driving slope failure is essential to assessing future geohazards. Here, we present a multidisciplinary study of a major submarine landslide complex along the eastern Ross Sea continental slope (Antarctica) that identifies preconditioning factors and failure mechanisms. Weak layers, identified beneath three submarine landslides, consist of distinct packages of interbedded Miocene- to Pliocene-age diatom oozes and glaciomarine diamicts. The observed lithological differences, which arise from glacial to interglacial variations in biological productivity, ice proximity, and ocean circulation, caused changes in sediment deposition …


Building Before: Community Resiliency As Emergency Management, Alexandria Rinne Apr 2023

Building Before: Community Resiliency As Emergency Management, Alexandria Rinne

Honors Program: Senior Projects (Public)

This project seeks to address gaps in emergency preparedness education related to tornado response. Through an examination of current research about best practices for tornado emergency management response and an examination of the needs of FEMA Regions 7 and 8, the author has identified key strategies and stakeholders to increase positive outcome through building community engagement and resiliency. Three presentations were created for delivery to key community stakeholders—local government officials; non-governmental organizations, social networks, and associations; and individual private citizens. The project offers an overview of background research and provides presentation slide decks, scripts, and discussion guides, all created with …


Job Stress Moderates The Effects Of A Mindfulness Intervention On Early Childhood Teachers' Emotion Dysregulation, Emily J. Starr Apr 2023

Job Stress Moderates The Effects Of A Mindfulness Intervention On Early Childhood Teachers' Emotion Dysregulation, Emily J. Starr

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Addressing the current crisis of early childhood (EC) teacher turnover is essential for supporting the development of young children. Teacher attrition remains a concern for policymakers globally, and in the United States, early childhood teachers frequently cite job stress and lack of support as reasons for leaving the field. For over 40 years, researchers who study childcare have been concerned about the consequences of work-related stressors. Even if these stressors do not result in turnover, EC teachers’ psychological well-being may be impacted, leading to increased emotion regulation difficulties and more frequent negative teacher-child interactions. Young children’s emotional development is significantly …


Cats Of Unl: An Investigation Into The Human-Feral Cat Relationships On A University Campus In Nebraska, Jacey Skoda Apr 2023

Cats Of Unl: An Investigation Into The Human-Feral Cat Relationships On A University Campus In Nebraska, Jacey Skoda

Honors Program: Senior Projects (Public)

At the University of Nebraska-Lincoln (UNL), there exists a population of feral cats that is monitored and cared for by a group known as Husker Cats. As the cats wander the sidewalks and gardens of the university, they may appear non-threatening and pleasant to have around. However, a feral cat presence could have detrimental impacts on the surrounding ecosystem, property, and community. The first component of this project, a survey of individuals on UNL campus, ultimately seeks to understand what those in the UNL community know about the feral cats, how they feel about the feral cats, and how they …


Multiple Case Study Of Science And Engineering Integration In Secondary School Across Six School Districts, Elizabeth Hasseler, Elizabeth B. Lewis Apr 2023

Multiple Case Study Of Science And Engineering Integration In Secondary School Across Six School Districts, Elizabeth Hasseler, Elizabeth B. Lewis

Department of Teaching, Learning, and Teacher Education: Faculty Publications

A multiple case study was conducted to investigate six districts’ approaches to integrating science and engineering curricula in their secondary education programs. Data collected included classroom observations, interviews with teachers and administrators, college transcripts, professional development, and curriculum, as well as how, and how district personnel supported, and teachers enacted classroom instruction to align with the Next Generation Science Standards (NGSS). Six districts were chosen due to their ranges in their size, urban or rural context, and demographics. There were 25 participants in the study who were either district personnel or secondary teachers. All school districts in the study incorporated …


Support Services And State Standardized Assessments For Homeless And High Mobility Youth: A Mixed Methods Case Study, Veronika Cummings Apr 2023

Support Services And State Standardized Assessments For Homeless And High Mobility Youth: A Mixed Methods Case Study, Veronika Cummings

Department of Educational Administration: Dissertations, Theses, and Student Research

For the past decade, the number of homeless youth in the United States has drastically increased, with public schools now consistently serving over one million homeless students each year. Research spanning three decades has linked youth homelessness and poorer academic achievement. In addition to decreased academic achievement, homeless and highly mobile (HHM) youth are more likely to suffer from mental health issues, have a behavioral diagnosis, engage in high-risk behavior, be truant, abuse drugs and alcohol, and even face premature death. Because homelessness is also frequently misidentified as solely an urban problem, it often results in HHM youth being left …


Influence Of Ambient Water Coloration On Habitat And Conspecific Choice In The Female Lake Malawi Cichlid, Metriaclima Zebra, Noori Choi, Nicolas Mathevon, Eileen A. Hebets, Marilyn Beauchaud Apr 2023

Influence Of Ambient Water Coloration On Habitat And Conspecific Choice In The Female Lake Malawi Cichlid, Metriaclima Zebra, Noori Choi, Nicolas Mathevon, Eileen A. Hebets, Marilyn Beauchaud

Eileen Hebets Publications

Female cichlid fish living in African great lakes are known to have sensory systems that are adapted to ambient light environments. These sensory system adaptations are hypothesized to have influenced the evolution of the diverse male nuptial coloration. In rock-dwelling Lake Malawi mbuna cichlids, however, the extent to which ambient light environments influence female sensory systems and potentially associated male nuptial coloration remains unknown. Yet, the ubiquitous blue flank coloration and UV reflection of male mbuna cichlids suggest the potential impacts of the blue-shifted ambient light environment on these cichlid’s visual perception and male nuptial coloration in the shallow water …


United States Census Bureau Statistical Quality Standards Apr 2023

United States Census Bureau Statistical Quality Standards

Copyright, Fair Use, Scholarly Communication, etc.

United States Census Bureau Statistical Quality Standards (April 19, 2023), the leading source of quality data about the nation's people and economy.


Science Club, Danielle Gibson, Krista Andersen Apr 2023

Science Club, Danielle Gibson, Krista Andersen

Honors Program: Expanded Learning Clubs

Honors After School program for elementary age children to engage with scientific principles. Students performed hands-on experiments to explore various STEM fields. Each weekly lesson consisted of a different concept to be learned or explored by early elementary aged students.


Examining Whether And How Instructional Coordination Occurs Within Introductory Undergraduate Stem Courses, Brian A. Couch, Luanna B. Prevost, Marilyne Stains, Blake Whitt, Ariel E. Marcy, Naneh Apkarian, Melissa H. Dancy, Charles Henderson, Estrella Johnson, Jeffrey R. Raker, Brandon J. Yik, Brittnee Earl, Susan E. Shadle, John Skvoretz, John P. Ziker Apr 2023

Examining Whether And How Instructional Coordination Occurs Within Introductory Undergraduate Stem Courses, Brian A. Couch, Luanna B. Prevost, Marilyne Stains, Blake Whitt, Ariel E. Marcy, Naneh Apkarian, Melissa H. Dancy, Charles Henderson, Estrella Johnson, Jeffrey R. Raker, Brandon J. Yik, Brittnee Earl, Susan E. Shadle, John Skvoretz, John P. Ziker

School of Biological Sciences: Faculty Publications

Instructors’ interactions can foster knowledge sharing around teaching and the use of research-based instructional strategies (RBIS). Coordinated teaching presents an impetus for instructors’ interactions and creates opportunities for instructional improvement but also potentially limits an instructor’s autonomy. In this study, we sought to characterize the extent of coordination present in introductory undergraduate courses and to understand how departments and instructors implement and experience course coordination. We examined survey data from 3,641 chemistry, mathematics, and physics instructors at three institution types and conducted follow-up interviews with a subset of 24 survey respondents to determine what types of coordination existed, what factors …


How Resilience Is Framed Matters For Governance Of Coastal Social-Ecological Systems, Sarah Clement, Javad Jozaei, Michael Mitchell, Craig R. Allen, Ahjond S. Garmestani Apr 2023

How Resilience Is Framed Matters For Governance Of Coastal Social-Ecological Systems, Sarah Clement, Javad Jozaei, Michael Mitchell, Craig R. Allen, Ahjond S. Garmestani

School of Natural Resources: Faculty Publications

Effective governance of social-ecological systems (SES) is an enduring challenge, especially in coastal environments where accelerating impacts of climate change are increasing pressure on already stressed systems. While resilience is often proposed as a suitable framing to re-orient governance and management, the literature includes many different, and sometimes conflicting, definitions and ideas that influence how the concept is applied, especially in coastal environments. This study combines discourse analysis of the coastal governance literature and key informant interviews in Tasmania, Australia, demonstrating inconsistencies and confusion in the way that resilience is framed in coastal governance research and practice. We find that …


Comparing Taste Perception Across Modalities In Healthy Adults: Liquids Versus Dissolvable Taste Strips, Ross M. Westemeyer, Angela M. Dietsch Apr 2023

Comparing Taste Perception Across Modalities In Healthy Adults: Liquids Versus Dissolvable Taste Strips, Ross M. Westemeyer, Angela M. Dietsch

Department of Special Education and Communication Disorders: Faculty Publications

Taste stimulation has rehabilitative value in dysphagia management, as it activates salient underlying afferent pathways to swallowing which may evoke feedforward effects on swallow biomechanics. Despite its potential beneficial effects on swallow physiology, taste stimulation’s clinical application is limited for persons unsafe to orally consume food/liquid. This study aimed to create edible, dissolvable taste strips matched to flavor profiles previously used in research assessing taste’s effects on swallowing physiology and brain activity, and to evaluate how similar their perceived intensity and hedonic, or palatability, ratings were between their liquid counterparts. Plain, sour, sweet–sour, lemon, and orange flavor profiles were custom-made …


Photographs And Parent Training To Support Conversations About Past Events Between Caregivers And Children With Autism, Naima Bhana, Tracy J. Raulston, Ciara Ousley, Atikah Bagawan Apr 2023

Photographs And Parent Training To Support Conversations About Past Events Between Caregivers And Children With Autism, Naima Bhana, Tracy J. Raulston, Ciara Ousley, Atikah Bagawan

Department of Special Education and Communication Disorders: Faculty Publications

Objectives Children with autism spectrum disorder experience communication difficulties that can make it challenging to engage in conversations. Their caregivers also often struggle with finding ways to support the child’s communication. Parent-implemented interventions and visual supports are evidence-based practices to support the communication skills of children with autism.

Method A multi-method design (single-case multiple probe and qualitative) was used to evaluate the effects of family photographs, training, and telecoaching on parental implementation of communication strategies. Three parents and their children with and at risk for autism participated.

Results Results indicate that the use of photographs increased the communication strategies used …


Fusarium Species Structure In Nebraska Corn, Yuchu Ma Apr 2023

Fusarium Species Structure In Nebraska Corn, Yuchu Ma

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Fusarium species are known to infect corn and cause significant yield losses and mycotoxin contamination worldwide. In this study, we investigated the diversity of Fusarium species infecting corn in Nebraska and their potential to produce fumonisins and trichothecenes. A total of 259 Fusarium isolates were collected from different corn tissues (ear, stalk, and root), revealing a significant association between the various Fusarium species complexes and different plant parts (p < 0.05). Fusarium incarnatum-equiseti species complex (FIESC) was the most widespread and abundant, followed by the Fusarium sambucinum (FSAMSC) and Fusarium fujikuroi species complexes (FFSC). In the subsequent analysis, we investigated the mycotoxin …


The Rna Cargo In Small Extracellular Vesicles From Chicken Eggs Is Bioactive In C57bl/6j Mice And Human Peripheral Blood Mononuclear Cells Ex Vivo, Deborah Fratantonio, Javaria Munir, Jiang Shu, Katherine Howard, Scott R. Baier, Juan Cui, Janos Zempleni Apr 2023

The Rna Cargo In Small Extracellular Vesicles From Chicken Eggs Is Bioactive In C57bl/6j Mice And Human Peripheral Blood Mononuclear Cells Ex Vivo, Deborah Fratantonio, Javaria Munir, Jiang Shu, Katherine Howard, Scott R. Baier, Juan Cui, Janos Zempleni

Department of Nutrition and Health Sciences: Faculty Publications

Small extracellular vesicles (sEVs) and their RNA cargo in milk are bioavailable in humans, pigs, and mice, and their dietary depletion and supplementation elicits phenotypes. Little is known about the content and biological activity of sEVs in foods of animal origin other than milk. Here we tested the hypothesis that sEVs in chicken eggs (Gallus gallus) facilitate the transfer of RNA cargo from an avian species to humans and mice, and their dietary depletion elicits phenotypes. sEVs were purified from raw egg yolk by ultracentrifugation and authenticated by transmission electron microscopy, nano-tracking device, and immunoblots. The miRNA profile …


Negotiating Asian American Identities: Collaborative Self-Study Of Korean Immigrant Scholars’ Reading Group On Asiancri, Taeyeon Kim, Soo Bin Jang, Jin Keong Jung, Minhye Son, Sun Young Lee Apr 2023

Negotiating Asian American Identities: Collaborative Self-Study Of Korean Immigrant Scholars’ Reading Group On Asiancri, Taeyeon Kim, Soo Bin Jang, Jin Keong Jung, Minhye Son, Sun Young Lee

Department of Educational Administration: Faculty Publications

The purpose of this study is to understand how Korean immigrant women early career scholars in higher education in the United States explore their Asian American identities in the identity-based community space. The study considered qualitative data generated by five authors in a collaborative reading group learning more about AsianCrit literature. Our analysis revealed that AsianCrit was used as a tool for revisiting our racialized experiences, negotiating tensions around key constructs of AsianCrit informed by transnational perspectives, and embracing Asian American identities in pursuit of solidarity. The findings contribute to expanding the scholarship of AsianCrit by highlighting its utility and …


“You Feel A Sense Of Accomplishment”: Outdoor Adventure Experiences Of Youths With Visual Impairments During A One-Week Sports Camp, Lauren J. Lieberman, Katie Ericson, Melanie Perreault, Pamela Beach, Kelsey Williams Apr 2023

“You Feel A Sense Of Accomplishment”: Outdoor Adventure Experiences Of Youths With Visual Impairments During A One-Week Sports Camp, Lauren J. Lieberman, Katie Ericson, Melanie Perreault, Pamela Beach, Kelsey Williams

Department of Special Education and Communication Disorders: Faculty Publications

There are many cognitive, physical, and social–emotional benefits for youths from participating in outdoor adventure activities. However, youths with visual impairments are not given the same opportunities to participate in outdoor adventure activities as their peers without disabilities. The purpose of this study was to examine the outdoor adventure experiences of youths with visual impairments participating in a week-long sports camp. Thirty-seven youths with visual impairment (ages 9–19 years) attending a one-week sports camp participated in this study. Participants engaged in a variety of outdoor adventure activities throughout the week of camp (e.g., sailing, hiking, rock climbing, biking, kayaking). Participants …


Towards A Global Sustainable Development Agenda Built On Social–Ecological Resilience, Murray W. Scown, Robin K. Craig, Craig R. Allen, Lance Gunderson, David G. Angeler, Jorge H. Garcia, Ahjond Garmestani Apr 2023

Towards A Global Sustainable Development Agenda Built On Social–Ecological Resilience, Murray W. Scown, Robin K. Craig, Craig R. Allen, Lance Gunderson, David G. Angeler, Jorge H. Garcia, Ahjond Garmestani

School of Natural Resources: Faculty Publications

Non-technical summary. The United Nations’ sustainable development goals (SDGs) articulate societal aspirations for people and our planet. Many scientists have criticised the SDGs and some have suggested that a better understanding of the complex interactions between society and the environment should underpin the next global development agenda. We further this discussion through the theory of social–ecological resilience, which emphasises the ability of systems to absorb, adapt, and transform in the face of change. We determine the strengths of the current SDGs, which should form a basis for the next agenda, and identify key gaps that should be filled.

Technical …


Study Of Lipophilicity And Adme Properties Of 1,9-Diazaphenothiazines With Anticancer Action, Beata Morak-Młodawska, Małgorzata Jeleń, Emilia Martula, Rafał Korlacki Apr 2023

Study Of Lipophilicity And Adme Properties Of 1,9-Diazaphenothiazines With Anticancer Action, Beata Morak-Młodawska, Małgorzata Jeleń, Emilia Martula, Rafał Korlacki

Department of Electrical and Computer Engineering: Faculty Publications

Lipophilicity is one of the key properties of a potential drug that determines the solubility, the ability to penetrate through cell barriers, and transport to the molecular target. It affects pharmacokinetic processes such as adsorption, distribution, metabolism, excretion (ADME). The 10-substituted 1,9-diazaphenothiazines show promising if not impressive in vitro anticancer potential, which is associated with the activation of the mitochondrial apoptosis pathway connected with to induction BAX, forming a channel in MOMP and releasing cytochrome c for the activation of caspases 9 and 3. In this publication, the lipophilicity of previously obtained 1,9-diazaphenothiazines was determined theoretically using various computer programs …


Study Of Lipophilicity And Adme Properties Of 1,9-Diazaphenothiazines With Anticancer Action, Beata Morak-Młodawska, Małgorzata Jeleń, Emilia Martula, Rafał Korlacki Apr 2023

Study Of Lipophilicity And Adme Properties Of 1,9-Diazaphenothiazines With Anticancer Action, Beata Morak-Młodawska, Małgorzata Jeleń, Emilia Martula, Rafał Korlacki

Department of Electrical and Computer Engineering: Faculty Publications

Lipophilicity is one of the key properties of a potential drug that determines the solubility, the ability to penetrate through cell barriers, and transport to the molecular target. It affects pharmacokinetic processes such as adsorption, distribution, metabolism, excretion (ADME). The 10-substituted 1,9-diazaphenothiazines show promising if not impressive in vitro anticancer potential, which is associated with the activation of the mitochondrial apoptosis pathway connected with to induction BAX, forming a channel in MOMP and releasing cytochrome c for the activation of caspases 9 and 3. In this publication, the lipophilicity of previously obtained 1,9-diazaphenothiazines was determined theoretically using various computer programs …


Mitochondrial Complex Iii Bypass Complex I To Induce Ros In Gpr17 Signaling Activation In Gbm, Sana Kari, Jeyalakshmi Kandhavelu, Akshaya Murugesan, Ramesh Thiyagarajan, Srivatsan Kidambi, Meenakshisundaram Kandhavelu Apr 2023

Mitochondrial Complex Iii Bypass Complex I To Induce Ros In Gpr17 Signaling Activation In Gbm, Sana Kari, Jeyalakshmi Kandhavelu, Akshaya Murugesan, Ramesh Thiyagarajan, Srivatsan Kidambi, Meenakshisundaram Kandhavelu

Department of Chemical and Biomolecular Engineering: Faculty Publications

Guanine nucleotide binding protein (G protein) coupled receptor 17 (GPR17) plays crucial role in Glioblastoma multiforme (GBM) cell signaling and is primarily associated with reactive oxidative species (ROS) production and cell death. However, the underlying mechanisms by which GPR17 regulates ROS level and mitochondrial electron transport chain (ETC) complexes are still unknown. Here, we investigate the novel link between the GPR17 receptor and ETC complex I and III in regulating level of intracellular ROS (ROSi) in GBM using pharmacological inhibitors and gene expression profiling. Incubation of 1321N1 GBM cells with ETC I inhibitor and GPR17 agonist decreased the ROS level, …