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Articles 5641 - 5670 of 38021
Full-Text Articles in Entire DC Network
Variation In White-Tailed Deer Antler Size: The Effects Of Age, Landscape Composition, And Physiographic Province., K. B. Quebedeaux, Andrew R. Little, N. P. Nibbelink, G. J. D'Angelo, C. H. Killmaster, K. V. Miller
Variation In White-Tailed Deer Antler Size: The Effects Of Age, Landscape Composition, And Physiographic Province., K. B. Quebedeaux, Andrew R. Little, N. P. Nibbelink, G. J. D'Angelo, C. H. Killmaster, K. V. Miller
School of Natural Resources: Faculty Publications
Spatial variation in landscape composition can influence phenotypic expression in wildlife species and can improve management efforts to express certain phenotypic traits. We evaluated the influence of age, landscape composition, and physiographic province on white-tailed deer (Odocoileus virginianus) antler characteristics using data from 16,622 male deer (age range: 1.5–3.5+ years old) harvested between 1997–2016 across five physiographic provinces in Georgia. Age and physiographic province influenced antler size index (ASI; P < 0.001). ASI of yearling males was greatest (- x = 53.37; SE = 0.39) in the Upper Coastal Plain and least (- x = 46.23; SE = 0.51) in the Lower Coastal Plain physiographic province. Given the differences in ASI among physiographic provinces, we evaluated how landscape composition within each physiographic province influenced ASI of 7,325 yearling (1.5-year-old) males. Yearling ASI was positively related to increasing coverage of cultivated crops and suburban-urban areas (e.g., parks, small housing developments). Conversely, evergreen and deciduous forested cover consistently had a negative effect on ASI, except in the Ridge and Valley physiographic province where evergreen was positively related to ASI. Wildlife managers and hunters should recognize the effects of age, landscape composition, and physiographic province when setting antler size expectations.
Tree-Ring Stable Isotopes Show Different Ecophysiological Strategies In Native And Invasive Woody Species Of A Semi-Arid Riparian Ecosystem In The Great Plains Of The United States, Tala Awada, Kristen Skolaut, Giovanna Battipaglia, Matthias Saurer, Diego A. Riveros-Iregui, Adam Schapaugh, Julie Huddle, Xinhua Zhou, Derrell Martin, Paolo Cherubini
Tree-Ring Stable Isotopes Show Different Ecophysiological Strategies In Native And Invasive Woody Species Of A Semi-Arid Riparian Ecosystem In The Great Plains Of The United States, Tala Awada, Kristen Skolaut, Giovanna Battipaglia, Matthias Saurer, Diego A. Riveros-Iregui, Adam Schapaugh, Julie Huddle, Xinhua Zhou, Derrell Martin, Paolo Cherubini
School of Natural Resources: Faculty Publications
No abstract provided.
The Adaptive Cycle: More Than A Metaphor, Shana M. Sundstrom, Craig R. Allen
The Adaptive Cycle: More Than A Metaphor, Shana M. Sundstrom, Craig R. Allen
School of Natural Resources: Faculty Publications
The adaptive cycle and its extension to panarchy (nested adaptive cycles) has been a useful metaphor and conceptual model for understanding long-term dynamics of change in ecological and social–ecological systems. We argue that adaptive cycles are ubiquitous in complex adaptive systems because they reflect endogenously generated dynamics as a result of processes of self-organization and evolution. We synthesize work from a wide array of fields to support this claim. If dynamics of growth, conservation, collapse and renewal are endogenous dynamics of complex adaptive systems, then there ought to be signals of system change over time that reflect this. We describe …
2019 Nebraska Water Productivity Report, Mesfin Mekonnen, Christopher Michael Usher Neale, Chittaranjan Ray, Galen E. Erickson, Adam Liska, Haishun Yang, Thiago L. Romanelli, Arjen Y. Hoekstra
2019 Nebraska Water Productivity Report, Mesfin Mekonnen, Christopher Michael Usher Neale, Chittaranjan Ray, Galen E. Erickson, Adam Liska, Haishun Yang, Thiago L. Romanelli, Arjen Y. Hoekstra
Daugherty Water for Food Global Institute: Faculty Publications
Nebraska’s agricultural production is diverse and vast, ranking the state fourth in total value of agricultural products in the U.S. The state is a national leader in terms of agricultural production: it is the third largest producer of corn and second largest in cattle production. Nebraska is also the second largest producer of ethanol and distillers’ grains. The production and use of these three commodities are highly interlinked. Corn is a major input in livestock feed and the ethanol industry. Ethanol plants then produce distillers’ grains as a co-product that is also used as livestock feed, thus forming what the …
Center For Grassland Studies, Volume 25, Issue 4, Winter 2019
Center For Grassland Studies, Volume 25, Issue 4, Winter 2019
Center for Grassland Studies: Newsletters
Ag Lenders Panel Provides Insight into Beef Systems Initiative
A Tribute to Jack Maddux
Science with a Story
Helping Cows Cope with Cold Stress
GRLS Internship: Intern and Provider Perspectives
PGAM Students Head to China in 2020
Annual Report: Nebraska Extension In Lancaster County, January 1, 2019 Through December 31, 2019
Annual Report: Nebraska Extension In Lancaster County, January 1, 2019 Through December 31, 2019
Lancaster County, Nebraska Extension: Reports
Lancaster County Extension information from 2019. Contents include:
1) About Extension - Lancaster County Extension mission statement, overview and impact reports;
2) Staff and Programs - staff directory and Extension Educator annual program summaries;
3) Financials - summaries of 2018-19 budget expenditures and current fiscal year 2019-20 budget; and
4) Media - website and social media information, samples of our monthly newsletter, the Nebline, and local newspaper articles.
Plant Root Systems Preserved In The Permian Cedar Mesa Sandstone At Moki Dugway, Southeastern Utah, David Loope
Plant Root Systems Preserved In The Permian Cedar Mesa Sandstone At Moki Dugway, Southeastern Utah, David Loope
Department of Earth and Atmospheric Sciences: Faculty Publications
Rooted green plants represent the base of the food chain for most terrestrial ecosystems, but, compared to animal burrows, root systems are relatively rarely recognized in ancient sedimentary rocks. Plant roots that penetrate unconsolidated sand dunes, especially those containing not only quartz grains, but also abundant grains of calcite (CaCO3), are commonly replaced by fine crystals of calcite (Klappa, 1980). These structures (known by geologists as rhizoliths from the Greek for “root rock”) are one form of calcite cemented soil and sediment called caliche (Figure 1). Caliche crystallizes well above the water table and its calcite crystals are …
Research And Creative Activity, July 1, 2018-June 30, 2019: Major Sponsored Programs And Faculty Awards For Research And Creative Activity, University Of Nebraska-Lincoln, Office Of Research And Economic Development, University Of Nebraska-Lincoln
Research And Creative Activity, July 1, 2018-June 30, 2019: Major Sponsored Programs And Faculty Awards For Research And Creative Activity, University Of Nebraska-Lincoln, Office Of Research And Economic Development, University Of Nebraska-Lincoln
Office of Research and Economic Development: Publications
Foreword by Bob Wilhelm, Vice Chancellor for Research and Economic Development:
This booklet highlights successes in research, scholarship and creative activity by University of Nebraska–Lincoln faculty during the fiscal year running July 1, 2018, to June 30, 2019.
It lists investigators, project titles and funding sources on major grants and sponsored awards received during the year; fellowships and other recognitions and honors bestowed on our faculty; books published by faculty; performances, exhibitions and other creative activity by our faculty; and patents and licensing agreements issued for products of Nebraska research.
2019 marks the university’s 150th anniversary, an exciting time to …
Market Claims And Efficacy Information In Direct‐To‐Consumer Prescription Drug Print Advertisements, Kathryn J. Aikin Phd, Kevin R. Betts Phd, Aysha Keisler Phd, Kathryn Schaefer Ziemer Phd
Market Claims And Efficacy Information In Direct‐To‐Consumer Prescription Drug Print Advertisements, Kathryn J. Aikin Phd, Kevin R. Betts Phd, Aysha Keisler Phd, Kathryn Schaefer Ziemer Phd
United States Food and Drug Administration: Publications
This study examined the impact of “New” and “#1 Prescribed” market claims and quantitative efficacy information on perceptions of a hypothetical prescription drug in a direct‐to‐consumer (DTC) print advertisement. We examined two market claims (New and #1 Prescribed), two efficacy levels (higher and lower), and a control condition without this information. Participants with diabetes were randomized to review one ad version and asked their perceptions of the ad's message, the drug's benefits, side effects and risks, doctors' opinions about the drug, and behavioral intention to use the drug, as well as recall and recognition of drug benefits and risks. Results …
Examining The Role Of Menthol Cigarettes In Progression To Established T Smoking Among Youth, James Nonnemaker, Shari P. Feirman, Anna Macmonegle, Bridget K. Ambrose, Kia J. Jackson, Megan J. Schroeder, Alexandria A. Smith, William Ridgeway, Olga Rass
Examining The Role Of Menthol Cigarettes In Progression To Established T Smoking Among Youth, James Nonnemaker, Shari P. Feirman, Anna Macmonegle, Bridget K. Ambrose, Kia J. Jackson, Megan J. Schroeder, Alexandria A. Smith, William Ridgeway, Olga Rass
United States Food and Drug Administration: Publications
Background: Menthol, a flavoring compound added to cigarettes, makes cigarettes more appealing to youth and inexperienced smokers and increases cigarettes' abuse liability. However, limited studies are available on menthol's role in smoking progression.
Methods: To assess the association between menthol in cigarettes and progression to established smoking, we used five waves of data from the Evaluation of Public Education Campaign on Teen Tobacco Cohort Study, a nationally representative longitudinal survey of U.S. youth conducted as part of “The Real Cost” evaluation. We used discrete time survival analysis to model the occurrence of two event outcomes—progression to established, current smoking and …
Revisiting The Historic Distribution And Habitats Of The Whooping Crane, Jane E. Austin, Matthew A. Hayes, Jeb A. Barzen
Revisiting The Historic Distribution And Habitats Of The Whooping Crane, Jane E. Austin, Matthew A. Hayes, Jeb A. Barzen
United States Geological Survey, Northern Prairie Wildlife Research Center: Publications
Understanding the historic range and habitats of an endangered species can assist in conservation and reintroduction efforts for that species. Individuals reintroduced into a species’ historic core range have a higher survival rate compared to individuals introduced near the periphery or outside the historic range (Falk and Olwell, 1992; Griffith et al., 1989). Individuals on the periphery of a species’ range tend to occupy less favorable habitats and have lower and more variable densities than those near the core of their range (Brown, 1984; Brown et al., 1995, 1996). Such conclusions, however, presume that historic habitats have not changed since …
Math Early On 2019
NebraskaMATH Materials
Math Early On, pg. 3
Mathematics in early childhood, pg. 6
Counting with props, pg. 9
Counting on and back, pg. 11
Exploring loose parts, pg. 14
A feel for numbers, pg. 17
The concept of take away, pg. 19
Sorting a collection, pg. 22
The great outdoors, pg. 24
Matching and moving, pg. 28
Using floor books, pg. 31
Pathway to comparing, pg. 34
Leadership team and participants, pg. 37
Genomic Prediction Using Canopy Coverage Image And Genotypic Information In Soybean Via A Hybrid Model, Reka Howard, Diego Jarquin
Genomic Prediction Using Canopy Coverage Image And Genotypic Information In Soybean Via A Hybrid Model, Reka Howard, Diego Jarquin
Department of Statistics: Faculty Publications
Prediction techniques are important in plant breeding as they provide a tool for selection that is more efficient and economical than traditional phenotypic and pedigree based selection. The conventional genomic prediction models include molecular marker information to predict the phenotype. With the development of new phenomics techniques we have the opportunity to collect image data on the plants, and extend the traditional genomic prediction models where we incorporate diverse set of information collected on the plants. In our research, we developed a hybrid matrix model that incorporates molecular marker and canopy coverage information as a weighted linear combination to predict …
Post-Er Stress Biogenesis Of Golgi Is Governed By Giantin, Cole P. Frisbie, Alexander Y. Lushnikov, Alexey V. Krasnoslobodtsev, Jean-Jack Riethoven, Jennifer L. Clarke, Elena I. Stepchenkova, Armen Petrosyan
Post-Er Stress Biogenesis Of Golgi Is Governed By Giantin, Cole P. Frisbie, Alexander Y. Lushnikov, Alexey V. Krasnoslobodtsev, Jean-Jack Riethoven, Jennifer L. Clarke, Elena I. Stepchenkova, Armen Petrosyan
Department of Statistics: Faculty Publications
Background: The Golgi apparatus undergoes disorganization in response to stress, but it is able to restore compact and perinuclear structure under recovery. This self-organization mechanism is significant for cellular homeostasis, but remains mostly elusive, as does the role of giantin, the largest Golgi matrix dimeric protein. Methods: In HeLa and different prostate cancer cells, we used the model of cellular stress induced by Brefeldin A (BFA). The conformational structure of giantin was assessed by proximity ligation assay and atomic force microscopy. The post-BFA distribution of Golgi resident enzymes was examined by 3D SIM high-resolution microscopy. Results: We detected that giantin …
Research At Nebraska, 2018-2019 Report, University Of Nebraska-Lincoln
Research At Nebraska, 2018-2019 Report, University Of Nebraska-Lincoln
Office of Research and Economic Development: Publications
This publication is a snapshot of the fiscal year’s activities. To read more stories about research and creativity at Nebraska, visit the online edition at https://research.unl.edu/annualreport/2019. Additional multimedia are available for many stories.
Identifying The Migratory Strategy Of The Lower Colorado River Valley Population Of Greater Sandhill Cranes, Courtenay M. Conring, Blake A. Grisham, Daniel P. Collins, Warren C. Conway
Identifying The Migratory Strategy Of The Lower Colorado River Valley Population Of Greater Sandhill Cranes, Courtenay M. Conring, Blake A. Grisham, Daniel P. Collins, Warren C. Conway
United States Fish and Wildlife Service: Publications
Across North America, Sandhill Cranes (Antigone canadensis) use an array of migratory strategies, ranging from “jumping,” or taking 1 or 2 flights from wintering grounds to a staging area, then on to the breeding grounds, to “hopping,” or taking shorter flights among multiple (>3) staging areas between termini. We captured 16 adult and 2 juvenile Greater Sandhill Cranes (Antigone canadensis tabida) from the Lower Colorado River Valley population (LCRVP) and fitted them with platform transmitter terminals (PTTs) for GPS satellite telemetry. We used recorded locations and Brownian bridge movement models (BBMMs) to identify migration corridors and areas of migratory …
Response Surface Analysis Of Genomic Prediction Accuracy Values Using Quality Control Covariates In Soybean, Diego Jarquin, Reka Howard, George L. Graef, Aaron Lorenz
Response Surface Analysis Of Genomic Prediction Accuracy Values Using Quality Control Covariates In Soybean, Diego Jarquin, Reka Howard, George L. Graef, Aaron Lorenz
Department of Agronomy and Horticulture: Faculty Publications
An important and broadly used tool for selection purposes and to increase yield and genetic gain in plant breeding programs is genomic prediction (GP). Genomic prediction is a technique where molecular marker information and phenotypic data are used to predict the phenotype (eg, yield) of individuals for which only marker data are available. Higher prediction accuracy can be achieved not only by using efficient models but also by using quality molecular marker and phenotypic data. The steps of a typical quality control (QC) of marker data include the elimination of markers with certain level of minor allele frequency (MAF) and …
Increasing The Concentration Of Linolenic Acid In Diets Fed To Jersey Cows In Late Lactation Does Not Affect Methane Production, J. V. Judy, G. C. Bachman, T. M. Brown-Brandl, S. C. Fernando, K. E. Hales, K. J. Harvatine, P. S. Miller, P. J. Kononoff
Increasing The Concentration Of Linolenic Acid In Diets Fed To Jersey Cows In Late Lactation Does Not Affect Methane Production, J. V. Judy, G. C. Bachman, T. M. Brown-Brandl, S. C. Fernando, K. E. Hales, K. J. Harvatine, P. S. Miller, P. J. Kononoff
Department of Animal Science: Faculty Publications
Although the inclusion of fat has reduced methane production in ruminants, relatively little research has been conducted comparing the effects of source and profile of fatty acids on methane production in lactating dairy cows. A study using 8 multiparous (325 ± 17 DIM; mean ± SD) lactating Jersey cows was conducted to determine effects of feeding canola meal and lard versus extruded byproduct containing flaxseed as a high-C18:3 fat source on methane production and diet digestibility in late-lactation dairy cows. A crossover design with 32-d periods (28-d adaptation and 4-d collections) was used to compare 2 different fat sources. Diets …
A Systematic Review Of Genetic Influence On Psychological Resilience, Kosuke Niitsu, Michael J. Rice, Julia F. Houfek, Scott F. Stoltenberg, Kevin A. Kupzyk, Cecilia R. Barron
A Systematic Review Of Genetic Influence On Psychological Resilience, Kosuke Niitsu, Michael J. Rice, Julia F. Houfek, Scott F. Stoltenberg, Kevin A. Kupzyk, Cecilia R. Barron
Department of Psychology: Faculty Publications
When exposed to adversity, some individuals are at an increased risk of posttraumatic stress disorder, experiencing persistent biopsychosocial disturbances, whereas others adapt well, described as resilience. Resilience is a complex biopsychosocial phenomenon conceptualized as adaptation to adversity influenced by an individual’s genetic variants, epistasis, epigenetics, and gene-by-environment interactions. Studies on psychological resilience have focused on behavioral and psychosocial variables with far less examination of the genetic contributions. The purpose of this review is to identify specific genetic variants contributing to the biological capacity for psychological resilience. PubMed and PsycINFO were searched using the following key words: psychological resilience AND genotype …
Mississippi Bottlenose Dolphin Workshop
Mississippi Bottlenose Dolphin Workshop
United States Marine Mammal Commission
Mississippi Bottlenose Dolphin Workshop
Flipping An Agricultural Teaching Methods Course At A Non-Land Grant University, Nathan W. Conner, Christopher T. Stripling, Stacy Tomas, Dennis Fennewald, Billye Foster
Flipping An Agricultural Teaching Methods Course At A Non-Land Grant University, Nathan W. Conner, Christopher T. Stripling, Stacy Tomas, Dennis Fennewald, Billye Foster
Department of Agricultural Leadership, Education, and Communication: Faculty Publications
The purpose of this study was to analyze undergraduate students’ perceptions of experiencing a flipped classroom in a teaching methods course at a Non-Land Grant Public Institution. The flipped classroom moves lectures and online videos outside of the classroom and uses class time for learning activities that promote problem-solving and discussion. Basic qualitative methods were used to provide flexibility, rich description, and the emergence of common patterns and themes. Participants reported the online lectures were beneficial and provided order and structure to the learning process. Personal responsibility emerged as a subtheme with mixed responses. Some participants felt it was the …
Flexible Stocking With Grass-Cast: A New Grassland Productivity Forecast To Reduce Weather Uncertainty, D. Peck, J. Derner, W. Parton, M. Hartman, B. Fuchs
Flexible Stocking With Grass-Cast: A New Grassland Productivity Forecast To Reduce Weather Uncertainty, D. Peck, J. Derner, W. Parton, M. Hartman, B. Fuchs
School of Natural Resources: Faculty Publications
No abstract provided.
Agroforestry Strategic Framework, Fiscal Years 2019-2024, Susan Stein
Agroforestry Strategic Framework, Fiscal Years 2019-2024, Susan Stein
United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications
America’s farmers, ranchers, and forest landowners are integrating trees with agriculture to address a variety of conservation and production goals. A unique land management approach, agroforestry provides opportunities to integrate productivity and profitability with environmental stewardship to support healthy, sustainable agriculture systems, economies, and communities.
Structural Basis Of 7sk Rna 5′ Γ-Phosphate Methylation And Retention By Mepce, Yuan Yang, Catherine D. Eichhorn, Yaqiang Wang, Duilio Cascio, Juli Feigon
Structural Basis Of 7sk Rna 5′ Γ-Phosphate Methylation And Retention By Mepce, Yuan Yang, Catherine D. Eichhorn, Yaqiang Wang, Duilio Cascio, Juli Feigon
Department of Chemistry: Faculty Publications
Among RNA 5′-cap structures, γ-phosphate monomethylation is unique to a small subset of noncoding RNAs, 7SK and U6 in humans. 7SK is capped by methylphosphate capping enzyme (MePCE), which has a second non-enzymatic role as a core component of the 7SK RNP that is an essential regulator of RNA transcription. We report 2.0 and 2.1 Å X-ray crystal structures of human MePCE methyltransferase domain bound to S-adenosylhomocysteine (SAH) and uncapped or capped 7SK substrates, respectively. 7SK recognition is achieved by protein contacts to a 5′ hairpin-single-stranded RNA region, explaining MePCE specificity for 7SK and U6. The structures reveal SAH and …
Functional Source Separation For Eeg-Fmri Fusion: Application To Steady-State Visual Evoked Potentials, Hong Ji, Badong Chen, Nathan M. Petro, Zejian Yuan, Nanning Zheng, Andreas Keil
Functional Source Separation For Eeg-Fmri Fusion: Application To Steady-State Visual Evoked Potentials, Hong Ji, Badong Chen, Nathan M. Petro, Zejian Yuan, Nanning Zheng, Andreas Keil
Center for Brain, Biology, and Behavior: Faculty Publications
Neurorobotics is one of the most ambitious fields in robotics, driving integration of interdisciplinary data and knowledge. One of the most productive areas of interdisciplinary research in this area has been the implementation of biologically-inspired mechanisms in the development of autonomous systems. Specifically, enabling such systems to display adaptive behavior such as learning from good and bad outcomes, has been achieved by quantifying and understanding the neural mechanisms of the brain networks mediating adaptive behaviors in humans and animals. For example, associative learning from aversive or dangerous outcomes is crucial for an autonomous system, to avoid dangerous situations in the …
Two Distinct Nucleic Acid Binding Surfaces Of Cdc5 Regulate Development, Chao Wang, Mu Li, Guorui Li, Wensheng Zhao, Bin Yu, Junfeng Liu, Jun Yang, You-Liang Peng
Two Distinct Nucleic Acid Binding Surfaces Of Cdc5 Regulate Development, Chao Wang, Mu Li, Guorui Li, Wensheng Zhao, Bin Yu, Junfeng Liu, Jun Yang, You-Liang Peng
Center for Plant Science Innovation: Faculty Publications
Cell division cycle 5 (Cdc5) is a highly conserved nucleic acid binding protein among eukaryotes and plays critical roles in development. Cdc5 can simultaneously bind to DNA and RNA by its N- terminal DNA-binding domain (DBD), but molecular mechanisms describing its nucleic acid recognition and the regulation of development through its nucleic acid binding remain unclear. Herein, we present a crystal structure of the N-terminal DBD of MoCdc5 (MoCdc5-DBD) from the rice blast fungus Magnaporthe oryzae. Residue K100 of MoCdc5 is on the periphery of a positively charged groove that is formed by K42, K45, R47, and N92 and is …
Science Club, Riha Karney, Brandon Vogel
Science Club, Riha Karney, Brandon Vogel
Honors Program: Expanded Learning Clubs
Science Club is an after school program that explores different concepts and activities in scientific disciplines, such as biology, chemistry, and physics, and allows students to open their minds and curiosity to the constantly changing scientific world.
"How It Works" After-School Club, Katharina Dvorak
"How It Works" After-School Club, Katharina Dvorak
Honors Program: Expanded Learning Clubs
This after-school club (intended for grades 3-5) will help students put their science learning in context by discussing how science (biology, chemistry, and physics) is important to our everyday lives.
Irruptions: Evidence For Breeding Season Habitat Limitation In Piping Plover (Charadrius Melodus), Samantha Robinson, James Fraser, Daniel Catlin, Sarah Karpanty, Jon Altman, Ruth Boettcher, Kevin Holcomb, Coral Huber, Kelsi Hunt, Alexandra Wilke
Irruptions: Evidence For Breeding Season Habitat Limitation In Piping Plover (Charadrius Melodus), Samantha Robinson, James Fraser, Daniel Catlin, Sarah Karpanty, Jon Altman, Ruth Boettcher, Kevin Holcomb, Coral Huber, Kelsi Hunt, Alexandra Wilke
United States Army Corps of Engineers, Omaha District
Effective management of wildlife populations requires identification of the factors limiting their growth. The Piping Plover (Charadrius melodus) is an imperiled, disturbance-dependent, shorebird species that nests on broad, sparsely vegetated beaches, sandbars, and lakeshores. In areas minimally affected by human use, plover habitat loss occurs through vegetation encroachment and erosion. Alternatively, habitat availability may be increased by sand deposition caused by storm- or flood-induced sediment transport or scouring that removes vegetation, or by receding lake levels. To test the hypothesis that plover populations are limited by available breeding habitat, we estimated the amount of habitat available before and after four …
Design And Characterization Of A Consensus Hemagglutinin Vaccine Immunogen Against H3 Influenza A Viruses Of Swine, Haiyan Sun, Jung-Hyang Sur, Sarah Vitosh-Sillman, David J. Steffen, Hiep Vu
Design And Characterization Of A Consensus Hemagglutinin Vaccine Immunogen Against H3 Influenza A Viruses Of Swine, Haiyan Sun, Jung-Hyang Sur, Sarah Vitosh-Sillman, David J. Steffen, Hiep Vu
Nebraska Center for Virology: Faculty Publications
The substantial genetic diversity exhibited by influenza A viruses of swine (IAV-S) represents the main challenge for the development of a broadly protective vaccine against this important pathogen. The consensus vaccine immunogen has proven an effective vaccinology approach to overcome the extraordinary genetic diversity of RNA viruses. In this project, we sought to determine if a consensus IAV-S hemagglutinin (HA) immunogen would elicit broadly protective immunity in pigs. To address this question, a consensus HA gene (designated H3-CON.1) was generated from a set of 1,112 H3 sequences of IAV-S recorded in GenBank from 2011 to 2015. The consensus HA gene …