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A Brief And True Report Of The New Found Land Of Virginia (1588), Thomas Hariot, Paul Royster , Editor Dec 1587

A Brief And True Report Of The New Found Land Of Virginia (1588), Thomas Hariot, Paul Royster , Editor

Electronic Texts in American Studies

This is an online electronic text edition of the first book published by an English colonist in America. Its author, Thomas Hariot or Harriot, was a cartographer, mathematician, astronomer, linguist, and philosopher, who was a participant in Sir Walter Ralegh’s first attempt to establish a colony in “Virginia,” on Roanoke Island in modern-day North Carolina, from June 1585 until June 1586. Hariot had learned the rudiments of the Algonkian language from two natives brought back to England from an earlier exploratory voyage, and he served as interpreter and liaison with the native peoples of the surrounding region. His Brief and …

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The Aerosphere As A Network Connector Of Organisms And Their Diseases, Jeremy D. Ross, Eli S. Bridge, Diann J. Prosser, John Y. Takekawa Dec 200

The Aerosphere As A Network Connector Of Organisms And Their Diseases, Jeremy D. Ross, Eli S. Bridge, Diann J. Prosser, John Y. Takekawa

United States Geological Survey: Staff Publications

Aeroecological processes, especially powered flight of animals, can rapidly connect biological communities across the globe. This can have profound consequences for evolutionary diversification, energy and nutrient transfers, and the spread of infectious diseases. The latter is of particular consequence for human populations, since migratory birds are known to host diseases which have a history of transmission into domestic poultry or even jumping to human hosts. In this chapter, we present a scenario under which a highly pathogenic avian influenza (HPAI) strain enters North America from East Asia via postmolting waterfowl migration. We use an agent-based model (ABM) to simulate the …

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Replicating Single-Cycle Adenovirus Vectors Generate Amplified Influenza Vaccine Responses, Catherine M. Crosby, William E. Matchett, Stephanie S. Anguiano-Zarate, Christopher A. Parks, Eric A. Weaver, Larry R. Pease, Richard J. Webby, Michael A. Barry Dec 200

Replicating Single-Cycle Adenovirus Vectors Generate Amplified Influenza Vaccine Responses, Catherine M. Crosby, William E. Matchett, Stephanie S. Anguiano-Zarate, Christopher A. Parks, Eric A. Weaver, Larry R. Pease, Richard J. Webby, Michael A. Barry

Nebraska Center for Virology: Faculty Publications

Head-to-head comparisons of conventional influenza vaccines with adenovirus (Ad) gene-based vaccines demonstrated that these viral vectors can mediate more potent protection against influenza virus infection in animal models. In most cases, Ad vaccines are engineered to be replication-defective (RD-Ad) vectors. In contrast, replication-competent Ad (RC-Ad) vaccines are markedly more potent but risk causing adenovirus diseases in vaccine recipients and health care workers. To harness antigen gene replication but avoid production of infectious virions, we developed “single-cycle” adenovirus (SC-Ad) vectors. Previous work demonstrated that SC-Ads amplify transgene expression 100-fold and produce markedly stronger and more persistent immune responses than RD-Ad vectors …

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