Digital Commons Network^™

Development Of The Novel Isoxazolo[3,4-D]Pyridazinone Scaffold, Which Positively Modulates The Metabotropic Glutamate Receptor Subtypes 2 And 4, Christina Ann Gates

Graduate Student Theses, Dissertations, & Professional Papers

The seven transmembrane (7TM) superfamily, also known as G-protein coupled receptors (GPCR), are one of the largest superfamilies in the human genome. With approximately 30% of marketed drugs targeting the GPCRs, these proteins are among the most successful as therapeutic targets. Within the GPCR receptor family there is a subgroup called the metabotropic glutamate receptors (mGluR). Compounds that target mGluRs are important for the treatment of a variety of central nervous system (CNS) disorders, as well as cancer. The mGluR2 subtype is a target for treatment of anxiety and schizophrenia. Activation of mGluR4 helps to ease the symptoms of Parkinson’s …

In The Shadow Of The Megadrought: Opportunities And Challenges For Addressing Loss And Damage From Climate Change In Chile And Eastern Montana, Usa, Elizabeth Grace Tobey

Graduate Student Theses, Dissertations, & Professional Papers

As the impacts of anthropogenic climate change mount, climate- related harms, both economic and non-economic, occur across every inhabited continent and disproportionately affect the world’s most vulnerable people. In response, the Loss and Damage agenda of the United Nations Framework Convention on Climate Change has emerged to address those climate-related harms that exceed human capacities for mitigation and adaptation. Significant questions remain regarding how losses and damages emerge across the globe and how Loss and Damage policy will be implemented to address those impacts. This thesis explores two specific questions: (1) national-level Loss and Damage policy mechanisms; and (2) perceptions …

A Comprehensive Forensic Case Report With The University Of Montana Forensic Anthropology Lab University Of Montana Forensic Case #167, Tyler J. Trettin

Graduate Student Theses, Dissertations, & Professional Papers

This report consists of an inventory of the skeletal remains of case# 167, assessment of the minimum number of individuals (MNI), a biological profile if possible, and a literature review of the assessment and understanding of ballistic trauma. The skeletal remains are consistent with an MNI of one. The remains are likely from a male individual, and skeletal features are representative of a person of Caucasian ancestry. The individual is estimated to be between of 35-65 years old with an estimated stature of between 5’5” and 5’9”.

Y-Chromosome Dna Extraction From Post-Cranial Skeletal Elements, Mykala D. Ward

Graduate Student Theses, Dissertations, & Professional Papers

The use of DNA in forensic science has become an integral tool for victim and perpetrator identifications, missing person’s cases, paternity testing, etc. A major use of DNA is in the identification of unknown deceased individuals. With a reported number of individuals well over 8,000 in the United States, improved methods to accurately collect and analyze DNA from modern human bone are needed.

This project took the preliminary steps to improve DNA sampling and extraction methods by analyzing the Y-chromosome DNA yield from the two bone types. While both types are composed of the same materials, cortical bone is the …

Parent And Child Characteristics Impacting Identification Of Children With Developmental Language Disorder (Dld), Sarah E. Floyd

Graduate Student Theses, Dissertations, & Professional Papers

Purpose: Previous research has shown that children with developmental language disorder (DLD) and dyslexia are under-identified in the general population. Parent or caregiver concern is a primary referral tool for these conditions, but may fail to accurately align with the actual presence of a disorder. The purpose of this study was to examine child and parent characteristics related to a child’s likelihood of receiving a diagnosis of DLD.

Methods: Within a large, 5-year, longitudinal study, kindergartener performance on a battery of speech, language, and literacy measures was examined to identify children with and without DLD and possible risk of dyslexia. …

Pharmacy-Based Immunization Laws And Adolescent Well-Child Checkup Tradeoffs: Results From The Nis-Teen 2019, Teigan Avery

Graduate Student Theses, Dissertations, & Professional Papers

Pharmacy-based immunization (PBI) has been heralded as a barrier-reducing way to immunize Americans and reach public health targets. PBI programs vary by state; some states prohibit vaccinating children in pharmacies while others allow pharmacists to prescribe and immunize persons of any age. There is concern that liberal PBI programs may boost vaccination rates at the cost of well-child visits. Parents may see PBI as an alternative to preventive well-check visits at a doctor’s office rather than as a complement, particularly for adolescents. This paper estimates the effect of state vaccination policies on individual adolescent 11–12-year-old well-checks using probit regression for …

The Genetic And Demographic Outcomes Of Mixed-Source Reintroductions Of Westslope Cutthroat Trout In Montana, Colter Austin Feuerstein

Graduate Student Theses, Dissertations, & Professional Papers

No abstract provided.

Deriving Surface Fuels From Uas Imagery Forfire Models, Matthew R. Cunningham

Graduate Student Theses, Dissertations, & Professional Papers

Understanding how fuel, weather, and terrain interact to produce fire behavior continues to motivate fire science andhas resulted in development of new physics-based fire behavior models that place increased demands on input data such as fuels. Recent technological advancements in computing, unmanned aerial systems (UAS), and sensors (RGB, multispectral, thermal, and hyperspectral cameras) can provide new opportunities for land managers and scientists to advance knowledge of fuels and fire behavior and their interactions on the landscape. In this study, imagery from high resolution multispectral cameras mounted on UAS were used to build orthomosaics and point clouds of surface fuelbeds in …

The Influence Of The First-Year Seminar Participation On Student Retention, Sahar Sanavi

Graduate Student Theses, Dissertations, & Professional Papers

College student retention is a complex phenomenon influenced by a myriad of factors and with wide-ranging implications for university function. First-year seminar is one approach to increase first-year student retention through involvement, engagement, and integration. This quantitative study examines the influence of first-year seminar on retention of first-year, full-time, four-year degree-seeking students who matriculated during the fall 2016, 2017, 2018 semester and remained enrolled for fall 2017, 2018, 2019 semester at six institutions in two Northwest states in the United States.

This study utilized an odds ratio to investigate whether first-year seminar participation had a statistically significant influence on the …

Unleaded: Montana’S Silent Epidemic, Erica Zurek

Graduate Student Theses, Dissertations, & Professional Papers

Lead is a cumulative toxin that can affect multiple systems in the human body. Exposure occurs through various sources, such as outdated and deteriorating infrastructure, paint, soil and drinking water. This project, a three-part audio series on lead exposure in Montana highlights various paths of exposure and how young children under age six years of age are particularly vulnerable. Part one is a story about a new state requirement to test all k-12 schools for lead in water fixtures. Part two: A house remodel exposes a family’s children to lead. Getting a diagnosis wasn’t easy. Part three: A look at …

A Thinking Person's Guide To Immigration And Environmental Racism At The Us - Mexico Border, Emma H. Kiefer

Graduate Student Theses, Dissertations, & Professional Papers

In recent years, more attention has been paid to the immigration crisis at the US-Mexico border thanks in part to the strict immigration restrictions from the Trump administration, such as the family separation policy. Immigration remains a widely misunderstood issue and arguments against increased immigration are often laced with racist stereotypes and perceptions that find their roots in centuries of US policy, court cases, and administrative rules. Similarly, the concept of environmental racism can be difficult for the American public to understand when modern-day racism alone has become more insidious. Intersectionality, a concept coined by sociologist Kimberlé Crenshaw, asks us …

Underwater: Science & Story In Aquatic Communities, Lena J. Beck

Graduate Student Theses, Dissertations, & Professional Papers

How do we manage fish species, and how do fish, in turn, impact us? This portfolio of three stories will explore some of the ways in which humans interact with aquatic landscapes. First, we’ll go to Flathead Lake in Montana, where invasive lake trout have all but decimated native trout species, and learn what the Confederated Salish and Kootenai Tribes are doing to address the issue. Then, we’ll examine stories of a legendary Big Fish in Alaska’s Lake Iliamna, and think about what it means to scientifically prove something as real. The last story looks at the aquaculture industry in …

Using Multiple Environmental Tracers To Estimate Field-Scale Longitudinal Dispersivity, Casey L. Kleppel

Graduate Student Theses, Dissertations, & Professional Papers

In this study, we seek to reduce parameter uncertainty in groundwater modeling systems, particularly in reactive transport models, by quantifying effective field-scale longitudinal dispersivity using anthropogenic environmental tracers. We generate synthetic aquifer fields and model transport of atmospheric tracers and test whether tracers can be used to determine an effective aquifer-scale dispersion coefficient. We generate synthetic datasets by simulating transport of chlorofluorocarbons (CFC11, CFC12, CFC113), sulfur-hexafluoride (SF₆) and tritium (³H) with input functions derived from known atmospheric concentrations, through a three-dimensional, stochastic, heterogeneous synthetic aquifer developed using sequential Gaussian simulation using the PFLOTRAN reactive transport model. …

Tales From A Placeholder: A Relational Journey With Land, Place, People And Self, Kalle O. Fox

Graduate Student Theses, Dissertations, & Professional Papers

The proposed thesis is a collection of place-based, long- and-short-form creative nonfiction essays. The places of interest are where the author spent different amounts of time in during her twenties, including Iceland, Miami and Seaside, Florida, Butte and Missoula, Montana, and a series of National Parks on the western side of the Continental Divide. This thesis is informed what cultural geographer Yi Fu Tuan coined as topophilia: the affective bond between people and place. “Place” and “sense of place,” while each having their own array of definitions in environmental scholarship, are considered interchangeable in the context of my work. A …

Taking Stock: Open Questions And Unfinished Business Under The Vawa Amendments To The Indian Civil Rights Act, Jordan Gross

Faculty Law Review Articles

The primary statutory tool for federal regulation of Tribal court criminal procedure is the Indian Civil Rights Act of 1968 (ICRA). ICRA replicated most of the procedural protections in the Bill of Rights applicable to the States, as then interpreted by the Supreme Court. ICRA also sets out procedures Tribes must extend to criminal defendants in their courts, caps their sentencing authority, and defines their criminal jurisdiction.

Some parts of Indian country are the most dangerous places in the United States today, particularly for indigenous women and girls. They are exposed to a higher level of personal violence than any …

Montana Kaimin, December 9, 2021, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Sb51-21/22-Resolution Amending Section 9 Of Fiscal Policy, Canyon S. Lock, Jack Rinck

Senate Resolutions, 2007-Present

SB51-21/22-Resolution Amending Section 9 of Fiscal Policy. This resolution passed unanimously during the December 8, 2021 meeting of the Associated Students of the University of Montana (ASUM).

Sb54-21/22: Resolution Endorsing The Big Sky Passenger Rail Authority, Canyon S. Lock, Mary Melissa Glueckert, Lauren O'Neill

Senate Resolutions, 2007-Present

SB54-21/22: Resolution Endorsing the Big Sky Passenger Rail Authority. This resolution passed 14Y-3N-2A during the December 8, 2021 meeting of the Associated Students of the University of Montana (ASUM).

Sb55-21/22: Resolution Endorsing The Use Of Student Facility Fees To Renovate Mansfield Library Level Four And Implement The University Of Montana Main Campus External Lighting Upgrade Project, Noah Durnell, Elizabeth Bowles, Canyon S. Lock

Senate Resolutions, 2007-Present

SB55-21/22: Resolution Endorsing the Use of Student Facility Fees to Renovate Mansfield Library Level Four and Implement the University of Montana Main Campus External Lighting Upgrade Project. This resolution passed unanimously during the December 8, 2021 meeting of the Associated Students of the University of Montana (ASUM).

Sb53-21/22: Resolution Amending The Asum Core Values, Mary Melissa Glueckert, Erin Heaton

Senate Resolutions, 2007-Present

SB53-21/22: Resolution Amending the ASUM Core Values. This resolution passed unanimously during the December 8, 2021 meeting of the Associated Students of the University of Montana (ASUM).

Sb52-21/22: Resolution Amending Article Iv, Section 4(6) Of The Asum Bylaws, Jack Rinck

Senate Resolutions, 2007-Present

SB52-21/22: Resolution Amending Article IV, Section 4(6) of the ASUM Bylaws. This resolution passed unanimously during the December 8, 2021 meeting of the Associated Students of the University of Montana (ASUM).

Preview; State V. Lafournaise, Brian Hagan

Montana Law Review Online

No abstract provided.

Ute Indian Tribe Of The Uintah & Ouray Reservation V. U.S. Dep't Of Interior, Valan Anthos

Public Land & Resources Law Review

The Ute Indian Tribe of the Uintah & Ouray Reservation brought 16 claims against federal agencies and the State of Utah for alleged mismanagement of water resources held in trust and for alleged discrimination in water allocation. The United States District Court for the District of Columbia dismissed several of the claims as time-barred and others as lacking a proper statutory basis to create an enforceable trust duty. The remaining claims were transferred to the United States District Court of the District of Utah because the events occurred in Utah and most of the parties reside there.

Montana Kaimin, December 2, 2021, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Chapter 3.1: Visualization Of The Nernst Equation Via 3-D Topo Surfaces: E⁰ Plateaus, Left-Hand Bluffs, Front Cliffs And Reaction Paths, Garon C. Smith, Md Mainul Hossain

Water Topos: A 3-D Trend Surface Approach to Viewing and Teaching Aqueous Equilibrium Chemistry

A new 3-D graphical representation of oxidation–reduction (redox) processes in aqueous solutions has been developed utilizing a composition grid for which the x-axis carries the activity of the reduced form of the redox couple and the y-axis carries the activity of the oxidized form. The Nernst equation potential corresponding to the redox couple’s activities at each grid point is plotted above it as a z-coordinate. This creates a 3-D trend surface (a topo) over the grid. The topos typically have a steep left-hand bluff and a precipitous front cliff that are encountered when one or the other …

Research Report: Social Isolation And Loneliness Experiences Among People With Disabilities Before And During Covid-19, University Of Montana Rural Institute

Health and Wellness

Increased risk and fear of exposure to COVID-19 may impact social isolation and loneliness among vulnerable populations who are disproportionately at risk of COVID-19 complications, like people with disabilities. In a previous report, research findings showed people with disabilities experienced more than double the rates of social isolation and loneliness compared to those without disabilities before the COVID-19 pandemic. While recent data indicates rates of social isolation and loneliness have increased for the general population with the onset of the COVID-19 pandemic, less is known how rates of social isolation and loneliness have shifted for people with disabilities. Data in …

Cases Vs. Statistics: A Crux In The History Of Medicine, Stewart Justman

Global Humanities and Religions Faculty Publications

During the 1720s in England, inoculation was described as a kind of engrafting, and we might say that proponents like James Jurin, the secretary of the Royal Society, engrafted the procedure itself onto their customary modes of thinking and doing. In Jurin’s case the transplant was particularly awkward, in that inoculation had already broken through the limitations he imposed on it by the time he picked up his pen.

Distribution Of Visitor Use Management Research In Us Wilderness From 2000 To 2020: A Scoping Review, William L. Rice, Christopher A. Armatas, Jennifer M. Thomsen, Jaclyn R. Rushing

Society and Conservation Faculty Publications

Visitor use in wilderness has grown over the past several decades, along with research focused on visitor use management (VUM) in congressionally designated wilderness. This scoping review of research published between 2000 and 2020 explores the distribution and representativeness of wilderness VUM research within the context of (a) the federal land management agencies administering wilderness and (b) the geographic distribution of research. Findings indicate wilderness administered by the Bureau of Land Management and US Fish and Wildlife Service were disproportionately understudied compared to both the total acreage of wilderness and number of wilderness areas administered by the US Forest Service …

Documents From The December 1, 2021 Meeting Of The Associated Students Of The University Of Montana (Asum), University Of Montana--Missoula. Associated Students

Senate Meeting Agendas and Minutes, 2007-Present

Agenda and meeting minutes from the December 1, 2021 meeting of the Associated Students of the University of Montana (ASUM). No resolutions were discussed during this meeting.

December 2021 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.