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Articles 9181 - 9210 of 94899
Full-Text Articles in Entire DC Network
Auditing Standards Board (Asb) & International Auditing Standards Task Force (Iastf), Meeting Highlights, December 2, 2021, Video Conference, American Institute Of Certified Public Accountants. Auditing Standards Board, International Auditing Standards Task Force (Iastf)
Auditing Standards Board (Asb) & International Auditing Standards Task Force (Iastf), Meeting Highlights, December 2, 2021, Video Conference, American Institute Of Certified Public Accountants. Auditing Standards Board, International Auditing Standards Task Force (Iastf)
Association Sections, Divisions, Boards, Teams
No abstract provided.
Auditing Standards Board (Asb), December 2, 2021, Meeting Agenda Teleconference, American Institute Of Certified Public Accountants. Auditing Standards Board, International Auditing Standards Task Force (Iastf)
Auditing Standards Board (Asb), December 2, 2021, Meeting Agenda Teleconference, American Institute Of Certified Public Accountants. Auditing Standards Board, International Auditing Standards Task Force (Iastf)
Association Sections, Divisions, Boards, Teams
No abstract provided.
Early Multicenter Experience With Imipenem-Cilastatin-Relebactam For Multidrug-Resistant Gram-Negative Infections, Nicholas Rebold, Taylor Morrisette, Abdalhamid M. Lagnf, Sara Alosaimy
Early Multicenter Experience With Imipenem-Cilastatin-Relebactam For Multidrug-Resistant Gram-Negative Infections, Nicholas Rebold, Taylor Morrisette, Abdalhamid M. Lagnf, Sara Alosaimy
Faculty and Student Publications
A multicenter case series of 21 patients were treated with imipenem-cilastatin-relebactam. There were mixed infection sources, with pulmonary infections (11/21,52%) composing the majority. The primary pathogen was Pseudomonas aeruginosa (16/21, 76%), and 15/16 (94%) isolates were multidrug-resistant. Thirty-day survival occurred in 14/21 (67%) patients. Two patients experienced adverse effects.
Cryo-Em Reveals The Architecture Of Placental Malaria Var2csa And Provides Molecular Insight Into Chondroitin Sulfate Binding, Kaituo Wang, Robert Dagil, Thomas Lavstsen, Sandeep K. Misra
Cryo-Em Reveals The Architecture Of Placental Malaria Var2csa And Provides Molecular Insight Into Chondroitin Sulfate Binding, Kaituo Wang, Robert Dagil, Thomas Lavstsen, Sandeep K. Misra
Faculty and Student Publications
Placental malaria can have severe consequences for both mother and child and effective vaccines are lacking. Parasite-infected red blood cells sequester in the placenta through interaction between parasite-expressed protein VAR2CSA and the glycosaminoglycan chondroitin sulfate A (CS) abundantly present in the intervillous space. Here, we report cryo-EM structures of the VAR2CSA ectodomain at up to 3.1 Å resolution revealing an overall V-shaped architecture and a complex domain organization. Notably, the surface displays a single significantly electropositive patch, compatible with binding of negatively charged CS. Using molecular docking and molecular dynamics simulations as well as comparative hydroxyl radical protein foot-printing of …
Identification Of A Solo Acylhomoserine Lactone Synthase From The Myxobacterium Archangium Gephyra, Hanan Albataineh, Maya Duke, Sandeep K. Misra, Joshua S. Sharp
Identification Of A Solo Acylhomoserine Lactone Synthase From The Myxobacterium Archangium Gephyra, Hanan Albataineh, Maya Duke, Sandeep K. Misra, Joshua S. Sharp
Faculty and Student Publications
Considered a key taxon in soil and marine microbial communities, myxobacteria exist as coordinated swarms that utilize a combination of lytic enzymes and specialized metabolites to facilitate predation of microbes. This capacity to produce specialized metabolites and the associated abundance of biosynthetic pathways contained within their genomes have motivated continued drug discovery efforts from myxobacteria. Of all myxobacterial biosynthetic gene clusters deposited in the antiSMASH database, only one putative acylhomoserine lactone (AHL) synthase, agpI, was observed, in genome data from Archangium gephyra. Without an AHL receptor also apparent in the genome of A. gephyra, we sought to determine if AgpI …
Characterization And In Vitro And In Vivo Evaluation Of Tacrolimus-Loaded Poly(Ε-Caprolactone) Nanocapsules For The Management Of Atopic Dermatitis, Guilherme Dos Anjos Camargo, Leandro Ferreira, Diego José Schebelski, Amanda Martinez Lyra
Characterization And In Vitro And In Vivo Evaluation Of Tacrolimus-Loaded Poly(Ε-Caprolactone) Nanocapsules For The Management Of Atopic Dermatitis, Guilherme Dos Anjos Camargo, Leandro Ferreira, Diego José Schebelski, Amanda Martinez Lyra
Faculty and Student Publications
Background: Tacrolimus (TAC) is a drug of natural origin used in conventional topical dosage forms to control atopic dermatitis. However, direct application of the drug often causes adverse side effects in some patients. Hence, drug nanoencapsulation could be used as an improved novel therapy to mitigate the adverse effects and enhance bioavailability of the drug. Methods: Physicochemical properties, in vitro drug release experiments, and in vivo anti-inflammatory activity studies were performed. Results: TAC-loaded nanocapsules were successfully prepared by the interfacial deposition of preformed polymer using poly(ε-caprolactone) (PCL). The nanoparticu-late systems presented a spherical shape with a smooth and regular surface, …
Extracts From Pulsatilla Patens Target Cancer-Related Signaling Pathways In Hela Cells, Grażyna Łaska, Magdalena Maciejewska-Turska, Elwira Sieniawska, Łukasz Świątek
Extracts From Pulsatilla Patens Target Cancer-Related Signaling Pathways In Hela Cells, Grażyna Łaska, Magdalena Maciejewska-Turska, Elwira Sieniawska, Łukasz Świątek
Faculty and Student Publications
The purpose of this study was to determine if a methanolic extract of the Pulsatilla patens (L.) Mill. can inhibit the progression of cancer through the modulation of cancer-related metabolic signaling pathways. We analyzed a panel of 13 inducible luciferase reporter gene vectors which expression is driven by enhancer elements that bind to specific transcription factors for the evaluation of the activity of cancer signaling pathways. The root extract of P. patens exhibited strong inhibition of several signaling pathways in HeLa cells, a cervical cancer cell line, and was found to be the most potent in inhibiting the activation of …
Functional Genomics Study Of Pseudomonas Putida To Determine Traits Associated With Avoidance Of A Myxobacterial Predator, Shukria Akbar, D. Cole Stevens
Functional Genomics Study Of Pseudomonas Putida To Determine Traits Associated With Avoidance Of A Myxobacterial Predator, Shukria Akbar, D. Cole Stevens
Faculty and Student Publications
Predation contributes to the structure and diversity of microbial communities. Predatory myxobacteria are ubiquitous to a variety of microbial habitats and capably consume a broad diversity of microbial prey. Predator–prey experiments utilizing myxobacteria have provided details into predatory mechanisms and features that facilitate consumption of prey. However, prey resistance to myxobacterial predation remains underexplored, and prey resistances have been observed exclusively from predator–prey experiments that included the model myxobacterium Myxococcus xanthus. Utilizing a predator–prey pairing that instead included the myxobacterium, Cystobacter ferrugineus, with Pseudomonas putida as prey, we observed surviving phenotypes capable of eluding predation. Comparative transcriptomics between P. putida …
Transmission Studies And The Composition Of Prokaryotic Communities Associated With Healthy And Diseased Aplysina Cauliformis Sponges Suggest That Aplysina Red Band Syndrome Is A Prokaryotic Polymicrobial Disease, Matteo Monti, Aurora Giorgi, Cole G. Easson, Deborah J. Gochfeld
Transmission Studies And The Composition Of Prokaryotic Communities Associated With Healthy And Diseased Aplysina Cauliformis Sponges Suggest That Aplysina Red Band Syndrome Is A Prokaryotic Polymicrobial Disease, Matteo Monti, Aurora Giorgi, Cole G. Easson, Deborah J. Gochfeld
Faculty and Student Publications
Aplysina cauliformis, the Caribbean purple rope sponge, is commonly affected by Aplysina Red Band Syndrome (ARBS). This transmissible disease manifests as circular lesions with red margins and results in bare spongin fibers. Leptolyngbya spp. appear to be responsible for the characteristic red coloration but transmission studies with a sponge-derived isolate failed to establish disease, leaving the etiology of ARBS unknown. To investigate the cause of ARBS, contact transmission experiments were performed between healthy and diseased sponges separated by filters with varying pore sizes. Transmission occurred when sponges were separated by filters with pore sizes ≥ 2.5 μm, suggesting a prokaryotic …
Assessing Bayesian Racism Scale: Measuring Endorsement Of Racial Stereotypes, Stacey Diane Arañez Litam, Richard S. Balkin
Assessing Bayesian Racism Scale: Measuring Endorsement Of Racial Stereotypes, Stacey Diane Arañez Litam, Richard S. Balkin
Faculty and Student Publications
Bayesian racism is the belief that it is rational to discriminate against people based on existing racial stereotypes. The presence of Bayesian racism is strongly associated with negative feelings about minoritized groups and the desire to maintain racially inequitable social hierarchies. A confirmatory factor analysis on the Bayesian Racism Scale (BRS) yielded a unidimensional measure for assessing prejudicial attitudes that endorse stereotypes based on racial and ethnic groups. Findings from the study have important implications for multicultural and social justice research.
Using Multiple Mendelian Randomization Approaches And Genetic Correlations To Understand Obesity, Urate, And Gout, Charleen D. Adams, Brian B. Boutwell
Using Multiple Mendelian Randomization Approaches And Genetic Correlations To Understand Obesity, Urate, And Gout, Charleen D. Adams, Brian B. Boutwell
Faculty and Student Publications
Observational studies suggest relationships between obesity, urate, and gout but are possibly confounded. We assessed whether genetically determined obesity, higher urate (and related traits), and gout were causal using multiple Mendelian randomization (MR) approaches and linkage disequilibrium score regression for genetic correlations (rg). For data, we used genome-wide association study summary statistics available through MR-Base. We observed that obesity increased urate (beta = 0.127; 95% CI = 0.098, 0.157; P-value = 1.2E−17; rg = 0.25 [P-value = 0.001]) and triglycerides (beta = 0.082; 95% CI = 0.065, 0.099; P-value = 1.2E−21; rg = 0.23 [P-value = 8.8E−12]) and decreased high-density …
Cognitive Determinants Of Weight Control By Dietary Patterns Among Postmenopausal Women With Osteoporosis: An Application Of Theory Of Planned Behavior, Hossein Hajizadeh, Pouria Sefidmooye Azar, Haidar Nadrian, Farhang Soltani Bejestani, Sousan Kolahi, Kritika Gupta
Cognitive Determinants Of Weight Control By Dietary Patterns Among Postmenopausal Women With Osteoporosis: An Application Of Theory Of Planned Behavior, Hossein Hajizadeh, Pouria Sefidmooye Azar, Haidar Nadrian, Farhang Soltani Bejestani, Sousan Kolahi, Kritika Gupta
Faculty and Student Publications
Background: In this study, we aimed to assess the cognitive determinants of weight control behaviors by dietary patterns among postmenopausal women with osteoporosis. Methods: This cross-sectional study, based on the theory of planned behavior (TPB) was conducted from July to December 2017 among 240 postmenopausal women with osteoporosis in Tabriz, Iran. A validated and reliable TPB-based instrument, namely Weight-CuRB, and the food frequency questionnaire (FFQ) were used. Results: The results of exploratory factor analysis (EFA) indicated three dietary patterns (total variance explained = 24.44%); healthy (n = 71), mixed (n = 78), and western (n = 91). In addition, food …
Issue 383: November 11-December 2, 2021, The Local Voice
Issue 383: November 11-December 2, 2021, The Local Voice
The Local Voice
No abstract provided.
Learning Orbital Dynamics Of Binary Black Hole Systems From Gravitational Wave Measurements, Brendan Keith, Akshay Khadse, Scott E. Field
Learning Orbital Dynamics Of Binary Black Hole Systems From Gravitational Wave Measurements, Brendan Keith, Akshay Khadse, Scott E. Field
Faculty and Student Publications
We introduce a gravitational waveform inversion strategy that discovers mechanical models of binary black hole (BBH) systems. We show that only a single time series of (possibly noisy) waveform data is necessary to construct the equations of motion for a BBH system. Starting with a class of universal differential equations parameterized by feed-forward neural networks, our strategy involves the construction of a space of plausible mechanical models and a physics-informed constrained optimization within that space to minimize the waveform error. We apply our method to various BBH systems including extreme and comparable mass ratio systems in eccentric and noneccentric orbits. …
Tracing The Origin Of The Crayfish Plague Pathogen, Aphanomyces Astaci, To The Southeastern United States, Laura Martín-Torrijos, María Martínez-Ríos, Gloria Casabella-Herrero, Susan B. Adams, Colin R. Jackson, Javier Diéguez-Uribeondo
Tracing The Origin Of The Crayfish Plague Pathogen, Aphanomyces Astaci, To The Southeastern United States, Laura Martín-Torrijos, María Martínez-Ríos, Gloria Casabella-Herrero, Susan B. Adams, Colin R. Jackson, Javier Diéguez-Uribeondo
Faculty and Student Publications
The oomycete Aphanomyces astaci is an emerging infectious pathogen affecting freshwater crayfish worldwide and is responsible for one of the most severe wildlife pandemics ever reported. The pathogen has caused mass mortalities of freshwater crayfish species in Europe and Asia, and threatens other susceptible species in Madagascar, Oceania and South America. The pathogen naturally coexists with some North American crayfish species that are its chronic carriers. Presumptions that A. astaci originated in North America are based on disease outbreaks that followed translocations of North American crayfish and on the identification of the pathogen mainly in Europe. We studied A. astaci …
Anharmonic Vibrational Frequencies Of Water Borane And Associated Molecules, Brent R. Westbrook, Ryan C. Fortenberry
Anharmonic Vibrational Frequencies Of Water Borane And Associated Molecules, Brent R. Westbrook, Ryan C. Fortenberry
Faculty and Student Publications
Water borane (BH3 OH2 ) and borinic acid (BH2 OH) have been proposed as intermediates along the pathway of hydrogen generation from simple reactants: water and borane. However, the vibrational spectra for neither water borane nor borinic acid has been investigaged experimen-tally due to the difficulty of isolating them in the gas phase, making accurate quantum chemical predictions for such properties the most viable means of their determination. This work presents theoretical predictions of the full rotational and fundamental vibrational spectra of these two poten-tially application-rich molecules using quartic force fields at the CCSD(T)-F12b/cc-pCVTZ-F12 level with additional corrections included for …
Study Of E+E- → D (1 S,2 S)Η And E+E- → D (1s)Η′ At S =10.866 Gev With The Belle Detector, E. Kovalenko, A. Garmash, P. Krokovny, I. Adachi, H. Aihara, D. M. Asner, V. Aulchenko, T. Aushev, R. Ayad, V. Babu, S. Bahinipati, P. Behera, J. Bennett, M. Bessner, T. Bilka, J. Biswal, A. Bobrov, A. Bondar, G. Bonvicini
Study Of E+E- → D (1 S,2 S)Η And E+E- → D (1s)Η′ At S =10.866 Gev With The Belle Detector, E. Kovalenko, A. Garmash, P. Krokovny, I. Adachi, H. Aihara, D. M. Asner, V. Aulchenko, T. Aushev, R. Ayad, V. Babu, S. Bahinipati, P. Behera, J. Bennett, M. Bessner, T. Bilka, J. Biswal, A. Bobrov, A. Bondar, G. Bonvicini
Faculty and Student Publications
We report the first observation of the processes e+e-→D(1S,2S)η at s=10.866 GeV, with significance exceeding 10σ for both processes. The measured Born cross sections are σ(e+e-→D(2S)η)=2.07±0.21±0.19 pb, and σ(e+e-→D(1S)η)=0.42±0.08±0.04 pb. We also set the upper limit on the cross section of the process e+e-→D(1S)η′ to be σ(e+e-→D(1S)η′)<0.037 pb at 90% C.L. The results are obtained with the data sample collected with the Belle detector at the KEKB asymmetric-energy e+e- collider in the energy range from 10.63 to 11.02 GeV.
Measurements Of Q2 Moments Of Inclusive B →Xcℓ+Νℓ Decays With Hadronic Tagging, R. Van Tonder, L. Cao, W. Sutcliffe, M. Welsch, F. U. Bernlochner, I. Adachi, H. Aihara, D. M. Asner, T. Aushev, R. Ayad, V. Babu, P. Behera, K. Belous, J. Bennett, M. Bessner, V. Bhardwaj, B. Bhuyan, T. Bilka, J. Biswal
Measurements Of Q2 Moments Of Inclusive B →Xcℓ+Νℓ Decays With Hadronic Tagging, R. Van Tonder, L. Cao, W. Sutcliffe, M. Welsch, F. U. Bernlochner, I. Adachi, H. Aihara, D. M. Asner, T. Aushev, R. Ayad, V. Babu, P. Behera, K. Belous, J. Bennett, M. Bessner, V. Bhardwaj, B. Bhuyan, T. Bilka, J. Biswal
Faculty and Student Publications
We present the measurement of the first to fourth order moments of the four-momentum transfer squared, q2, of inclusive B→Xcℓ+νℓ decays using the full Belle dataset of 711 fb-1 of integrated luminosity at the (4S) resonance where ℓ=e, μ. The determination of these moments and their systematic uncertainties open new pathways to determine the absolute value of the Cabibbo-Kobayashi-Maskawa matrix element Vcb using a reduced set of matrix elements of the heavy quark expansion. In order to identify and reconstruct the Xc system, we reconstruct one of the two B-mesons using machine learning techniques in fully hadronic decay modes. The …
Leadership Matters: December 2021, University Of Mississippi. Lott Leadership Institute
Leadership Matters: December 2021, University Of Mississippi. Lott Leadership Institute
Student Newsletters
Includes "Open Doors for Others: in other words, Lead", by Morgan Atkins
The Belle Ii Online–Offline Data Operations System, Matthew Barrett, Takanori Hara, Michel Hernández Villanueva, Kunxian Huang, Dhiraj Kalita, Petteri Kettunen, Prashant Shingade
The Belle Ii Online–Offline Data Operations System, Matthew Barrett, Takanori Hara, Michel Hernández Villanueva, Kunxian Huang, Dhiraj Kalita, Petteri Kettunen, Prashant Shingade
Faculty and Student Publications
Data collection at the Belle II experiment started in the spring of 2019. During the early stages of the experiment it is important that the raw data are both copied to permanent storage and made available soon after being recorded to allow for the timely commissioning and calibration of the detector. Automated procedures have been developed to transfer the data from the detector in a timely manner; these procedures include fault management, performance monitoring, and quality checks. It is important that the systems put in place will also scale to the much higher data rates expected in the coming years …
Framing And Agenda Setting Of The Day Of Republika Srpska And Its 2016 Referendum, Nađa Beglerović, Matthew T. Becker
Framing And Agenda Setting Of The Day Of Republika Srpska And Its 2016 Referendum, Nađa Beglerović, Matthew T. Becker
Faculty and Student Publications
The purpose of this article is to explore broadsheet newspaper framing and agenda- setting of two events using the five- frame model developed by Semetko and Valkenburg (2000). This article provides insight into how the leading broadsheet newspaper within BiH’s Republika Srpska frames relationships between the three main ethnic groups and is the first such study to occur in BiH. By identifying and exploring the most common frames in Glas Srpske during the five -year period (from 31 December 2015 to 30 December 2020), the research is meant to answer the following research questions: How does Glas Srpske frame the …
A Multiwell Plate-Based System For Toxicity Screening Under Multiple Static Or Cycling Oxygen Environments, Ming Yao, Glenn Walker, Michael P. Gamcsik
A Multiwell Plate-Based System For Toxicity Screening Under Multiple Static Or Cycling Oxygen Environments, Ming Yao, Glenn Walker, Michael P. Gamcsik
Faculty and Student Publications
Tumor tissue contains a continuous distribution of static and dynamically changing oxygen environments with levels ranging from physiologically normal oxygen down to anoxia. However, in vitro studies are often performed under oxygen levels that are far higher than those found in vivo. A number of devices are available to alter the oxygen environment in cell culture, including designs from our laboratory. However, in our devices and most other designs, changing the media in order to feed or dose cells remains a disruptive factor in maintaining a consistent hypoxic environment. This report presents a novel 96-well plate design that recirculates the …
Software Training In Hep, Sudhir Malik, Samuel Meehan, Kilian Lieret, Meirin Oan Evans, Michel H. Villanueva, Daniel S. Katz, Graeme A. Stewart, Peter Elmer, Sizar Aziz, Matthew Bellis, Riccardo Maria Bianchi, Gianluca Bianco, Johan Sebastian Bonilla, Angela Burger, Jackson Burzynski, David Chamont, Matthew Feickert, Philipp Gadow, Bernhard Manfred Gruber
Software Training In Hep, Sudhir Malik, Samuel Meehan, Kilian Lieret, Meirin Oan Evans, Michel H. Villanueva, Daniel S. Katz, Graeme A. Stewart, Peter Elmer, Sizar Aziz, Matthew Bellis, Riccardo Maria Bianchi, Gianluca Bianco, Johan Sebastian Bonilla, Angela Burger, Jackson Burzynski, David Chamont, Matthew Feickert, Philipp Gadow, Bernhard Manfred Gruber
Faculty and Student Publications
The long-term sustainability of the high-energy physics (HEP) research software ecosystem is essential to the field. With new facilities and upgrades coming online throughout the 2020s, this will only become increasingly important. Meeting the sustainability challenge requires a workforce with a combination of HEP domain knowledge and advanced software skills. The required software skills fall into three broad groups. The first is fundamental and generic software engineering (e.g., Unix, version control, C++, and continuous integration). The second is knowledge of domain-specific HEP packages and practices (e.g., the ROOT data format and analysis framework). The third is more advanced knowledge involving …
Daily Digest - Wednesday, December 1, 2021 Covid-19 Updates, University Of Mississippi
Daily Digest - Wednesday, December 1, 2021 Covid-19 Updates, University Of Mississippi
COVID-19 Website Archives
Campus Update Daily Digest for Wednesday, December 1, 2021
University Recognizes Employees For 25 Years Of Service, Staff Report
University Recognizes Employees For 25 Years Of Service, Staff Report
University of Mississippi News
No abstract provided.
From Crafting Cardboard To Creating A Company, Shea Stewart
From Crafting Cardboard To Creating A Company, Shea Stewart
University of Mississippi News
CME student, Ole Miss business major starts company creating 'man cave must-have'
Mentor, Supporter And Red-And-Blue Through And Through, Stella Connell
Mentor, Supporter And Red-And-Blue Through And Through, Stella Connell
University of Mississippi News
Lila Neely retires, leaving a legacy of MBA graduates and success stories
Patch Size Drives Colonization By Aquatic Insects, With Minor Priority Effects Of A Cohabitant, Reed C. Scott, Matthew R. Pintar, William J. Resetarits
Patch Size Drives Colonization By Aquatic Insects, With Minor Priority Effects Of A Cohabitant, Reed C. Scott, Matthew R. Pintar, William J. Resetarits
Faculty and Student Publications
Patch size is one of the most important factors affecting the distribution and abundance of species, and recent research has shown that patch size is an important niche dimension affecting community structure in aquatic insects. Building on this result, we examined the impact of patch size in conjunction with presence of larval anurans on colonization by aquatic insects. Hyla chrysoscelis (Cope's gray treefrog) larvae are abundant and early colonists in fishless lentic habitats, and these larvae can fill multiple ecological roles. By establishing larvae in mesocosms prior to colonization, we were able to assess whether H. chrysoscelis larvae have priority …
Test Transferability Of 3d-Mot Training On Soccer Specific Parameters, Micaela Dusseault
Test Transferability Of 3d-Mot Training On Soccer Specific Parameters, Micaela Dusseault
Honors Theses
Objective: The benefits of perceptual-cognitive training in elite level athletes has recently been investigated in multiple sports such as basketball, soccer, and archery, but conclusive evidence proving test transferability of 3D-MOT training is lacking. The purpose of this research is to examine the transferability of perceptual-cognitive training to on-field soccer performance parameters. Participants: NCAA Division I women’s soccer players (n=22) between the ages of 18-25 who were placed into either the experimental group (n=10) or control group (n=12). After baseline testing for both groups to determine visual tracking speed (VTS), the experimental group completed 10 3D-MOT training sessions with NeuroTracker …
Independence Considerations For Information Systems Services, December 2021; Practice Aid, American Institute Of Certified Public Accountants (Aicpa)
Independence Considerations For Information Systems Services, December 2021; Practice Aid, American Institute Of Certified Public Accountants (Aicpa)
Guides, Handbooks and Manuals
No abstract provided.