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Synthesis Of Methanediol [Ch2(Oh)2]: The Simplest Geminal Diol, Cheng Zhu, N. Fabian Kleimeier, Andrew M. Turner, Santosh K. Singh, Ryan C. Fortenberry, Ralf I. Kaiser Jan 2022

Synthesis Of Methanediol [Ch2(Oh)2]: The Simplest Geminal Diol, Cheng Zhu, N. Fabian Kleimeier, Andrew M. Turner, Santosh K. Singh, Ryan C. Fortenberry, Ralf I. Kaiser

Faculty and Student Publications

Geminal diols—organic molecules carrying two hydroxyl groups at the same carbon atom—have been recognized as key reactive intermediates by the physical (organic) chemistry and atmospheric science communities as fundamental transients in the aerosol cycle and in the atmospheric ozonolysis reaction sequence. Anticipating short lifetimes and their tendency to fragment to water plus the aldehyde or ketone, free geminal diols represent one of the most elusive classes of organic reactive intermediates. Here, we afford an exceptional glance into the preparation of the previously elusive methanediol [CH2(OH)2] transient—the simplest geminal diol—via energetic processing of low-temperature methanol–oxygen ices. Methanediol was identified in the …

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Touring Exhibit Examines 'Americans And The Holocaust', Edwin B. Smith Jan 2022

Touring Exhibit Examines 'Americans And The Holocaust', Edwin B. Smith

University of Mississippi News

No abstract provided.

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Improving The Well-Being Of Mississippi Children, Shea Stewart Jan 2022

Improving The Well-Being Of Mississippi Children, Shea Stewart

University of Mississippi News

University receives grant to expand preschool curriculum

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Um Community Remembers Former Journalism Educator Nancy Dupont, Carter Diggs Jan 2022

Um Community Remembers Former Journalism Educator Nancy Dupont, Carter Diggs

University of Mississippi News

Professor's influence and steady guidance stretched to all corners of campus and around the world

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Precepts Of Professional Conduct, N.D., American Institute Of Certified Public Accountants (Aicpa) Jan 2022

Precepts Of Professional Conduct, N.D., American Institute Of Certified Public Accountants (Aicpa)

Guides, Handbooks and Manuals

No abstract provided.

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Leveraging The Influence Of Power Grid Links In Renewable Energy Power Generation, Wei Wang, Haibo Wang, Bahram Alidaee, Jun Huang, Huijun Yang Jan 2022

Leveraging The Influence Of Power Grid Links In Renewable Energy Power Generation, Wei Wang, Haibo Wang, Bahram Alidaee, Jun Huang, Huijun Yang

Faculty and Student Publications

Smart grid construction provides the basic conditions for grid connection of renewable energy power generation. However, the grid connection of large-scale intermittent renewable energy sources increases the complexity of operational control of power systems. With the increase in intermittent renewable energy grid connections, distribution system operators must optimize and integrate these new participants to ensure the flexibility and stability of smart grids. Dividing the smart grid into logical clusters helps to overcome the problems caused by intermittent renewable energy grid connections. In this study, we propose a 2-step modeling approach that includes both link and leverage analyses to detect the …

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Major And Minor Flyer, University Of Mississippi. College Of Liberal Arts Jan 2022

Major And Minor Flyer, University Of Mississippi. College Of Liberal Arts

Liberal Arts Publications

A pamphlet listing the 35 majors and 52 minors available through the College of Liberal Arts.

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School Of Pharmacy Intellectual Property Report, Fy22, Second Quarter Report, Soumyajit Majumdar Jan 2022

School Of Pharmacy Intellectual Property Report, Fy22, Second Quarter Report, Soumyajit Majumdar

U. S. Patents, School of Pharmacy

No abstract provided.

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Phytochemical Investigation Of Egyptian Riverhemp: A Potential Source Of Antileukemic Metabolites, Shimaa M. Abdelgawad, Mona H. Hetta, Mohamed A. Ibrahim, Premalatha Balachandran Jan 2022

Phytochemical Investigation Of Egyptian Riverhemp: A Potential Source Of Antileukemic Metabolites, Shimaa M. Abdelgawad, Mona H. Hetta, Mohamed A. Ibrahim, Premalatha Balachandran

Faculty and Student Publications

As part of our research group's continuous efforts to find alternative treatments for cancer, the aqueous ethanol extract of Sesbania sesban L. Merr. (SS, Egyptian riverhemp) demonstrated an antileukemic activity against K562 cell line. Bioguided fractionation of SS leaves hydroethanolic extract resulted in the isolation of one new compound (33) named as hederatriol 3-O-β-D-glucuronic acid methyl ester as well as 34 known compounds. Seven compounds ((34), (22), (20), (24), (21), (19), and (35)) showed high antiproliferative effects (IC50 = 22.3, 30.8, 31.3, 33.7, 36.6, 37.5, and 41.5 μM, respectively), while four compounds ((32), (5), (29), and (1)) showed milder activities …

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Cryptococcosis In A Patient With Multiple Myeloma Receiving Pomalidomide: A Case Report And Literature Review, Daniel B. Chastain, Sahand Golpayegany, Andrés F. Henao-Martínez, Brittany T. Jackson Jan 2022

Cryptococcosis In A Patient With Multiple Myeloma Receiving Pomalidomide: A Case Report And Literature Review, Daniel B. Chastain, Sahand Golpayegany, Andrés F. Henao-Martínez, Brittany T. Jackson

Faculty and Student Publications

While overall survival with multiple myeloma (MM) has improved, patients suffer from overwhelming tumor burden, MM-associated comorbidities, and frequent relapses requiring administration of salvage therapies. As a result, this vicious cycle is often characterized by cumulative immunodeficiency stemming from a combination of disease- and treatment-related factors leading to neutropenia, T-cell deficiency, and hypogammaglobulinemia. Infectious etiologies differ based on the duration of MM and treatment-related factors, such as number of previous treatments and cumulative dose of corticosteroids. Herein, we present the case of a patient who was receiving pomalidomide without concomitant corticosteroids for MM and was later found to have cryptococcosis, …

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Age-Related Neuroendocrine, Cognitive, And Behavioral Co-Morbidities Are Promoted By Hiv-1 Tat Expression In Male Mice, Alaa N. Qrareya, Fakhri Mahdi, Marc J. Kaufman, Nicole M. Ashpole Jan 2022

Age-Related Neuroendocrine, Cognitive, And Behavioral Co-Morbidities Are Promoted By Hiv-1 Tat Expression In Male Mice, Alaa N. Qrareya, Fakhri Mahdi, Marc J. Kaufman, Nicole M. Ashpole

Faculty and Student Publications

In the U.S. about half of the HIV-infected individuals are aged 50 and older. In men living with HIV, secondary hypogonadism is common and occurs earlier than in seronegative men, and its prevalence increases with age. While the mechanisms(s) are unknown, the HIV-1 trans-activator of transcription (Tat) protein disrupts neuroendocrine function in mice partly by dysregulating mitochondria and neurosteroidogenesis. We hypothesized that conditional Tat expression in middle-aged male transgenic mice [Tat(+)] would promote age-related comorbidities compared to age-matched controls [Tat(−)]. We expected Tat to alter steroid hormone milieu consistent with behavioral deficits. Middle-aged Tat(+) mice had lower circulating testosterone and …

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Synthesis Of 3,4,5-Trisubstituted Isoxazoles In Water Via A [3 + 2]-Cycloaddition Of Nitrile Oxides And 1,3-Diketones, Β-Ketoesters, Or Β-Ketoamides, Md Imran Hossain, Md Imdadul H. Khan, Seong Jong Kim, Hoang V. Le Jan 2022

Synthesis Of 3,4,5-Trisubstituted Isoxazoles In Water Via A [3 + 2]-Cycloaddition Of Nitrile Oxides And 1,3-Diketones, Β-Ketoesters, Or Β-Ketoamides, Md Imran Hossain, Md Imdadul H. Khan, Seong Jong Kim, Hoang V. Le

Faculty and Student Publications

Herein we report a method for the synthesis of 3,4,5-trisubstituted isoxazoles in water under mild basic conditions at room temperature via a [3 + 2]-cycloaddition of nitrile oxides and 1,3-diketones, β-ketoesters, or β-ketoamides. We optimized the reaction conditions to control the selectivity of the production of isoxazoles and circumvent other competing reactions, such as O-imidoylation or hetero [3 + 2]-cycloaddition. The reaction happens fast in water and completes within 1-2 hours, which provides an environmentally friendly access to 3,4,5-trisubstituted isoxazoles, an important class of structures found in numerous bioactive natural products and pharmaceuticals. Additionally, we optimized the reaction conditions to …

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Identification Of An Orally Bioavailable, Brain-Penetrant Compound With Selectivity For The Cannabinoid Type 2 Receptor, Meirambek Ospanov, Suresh P. Sulochana, Jason J. Paris, John M. Rimoldi Jan 2022

Identification Of An Orally Bioavailable, Brain-Penetrant Compound With Selectivity For The Cannabinoid Type 2 Receptor, Meirambek Ospanov, Suresh P. Sulochana, Jason J. Paris, John M. Rimoldi

Faculty and Student Publications

Modulation of the endocannabinoid system (ECS) is of great interest for its therapeutic relevance in several pathophysiological processes. The CB2 subtype is largely localized to immune effectors, including microglia within the central nervous system, where it promotes anti-inflammation. Recently, a rational drug design toward precise modulation of the CB2 active site revealed the novelty of Pyrrolo[2,1-c][1,4]benzodiazepines tricyclic chemotype with a high conformational similarity in comparison to the existing leads. These compounds are structurally unique, confirming their chemo-type novelty. In our continuing search for new chemotypes as selective CB2 regulatory molecules, following SAR approaches, a total of 17 selected (S,E)-11-[2-(arylmethylene)hydrazono]-PBD analogs …

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1,2,3-Triazole Derivatives As Highly Selective Cannabinoid Receptor Type 2 (Cb2) Agonists, Amer H. Tarawneh, Pankaj Pandey, Lo'ay A. Al-Momani, Anastassiya V. Gadetskaya Jan 2022

1,2,3-Triazole Derivatives As Highly Selective Cannabinoid Receptor Type 2 (Cb2) Agonists, Amer H. Tarawneh, Pankaj Pandey, Lo'ay A. Al-Momani, Anastassiya V. Gadetskaya

Faculty and Student Publications

The cannabinoid receptor 2 (CB2 receptor) has attracted considerable interest, mainly due to its potential as a target for therapeutics for treating various diseases that have a neuroinflammatory or neurodegenerative component while avoiding the adverse psychotropic effects that accompany CB1 receptor-based therapies. With the appreciation that CB2-selective ligands show marked functional selectivity, there is a renewed opportunity to explore this promising area of research from both a mechanistic as well as a therapeutic perspective. In this research, we are interested in the discovery of new chemotypes as highly selective CB2 modulators, which may serve as good starting points for further …

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Dual Drug Loaded Lipid Nanocarrier Formulations For Topical Ocular Applications, Ahmed Adel Ali Youssef, Narendar Dudhipala, Soumyajit Majumdar Jan 2022

Dual Drug Loaded Lipid Nanocarrier Formulations For Topical Ocular Applications, Ahmed Adel Ali Youssef, Narendar Dudhipala, Soumyajit Majumdar

Faculty and Student Publications

Introduction: Untreated ocular infections can damage the unique fine structures of the eye with possible visual impairments and blindness. Ciprofloxacin (CIP) ophthalmic solution is prescribed as first-line therapy in ocular bacterial infections. Natamycin (NT) ophthalmic suspension is one of the progenitors in ocular antifungal therapy. Nanostructured lipid carriers (NLCs) have been widely examined for ocular penetration enhancement and distribution to deeper ocular tissues. The objective of the current study was to prepare NLCs loaded with a combination of CIP and NT (CIP-NT-NLCs) and embed them in an in-situ gelling system (CIP-NT-NLCs-IG). This novel formulation will target the co-delivery of CIP …

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Study Of B ¯ 0 →D+H- (H=K/Π) Decays At Belle Study Of B ¯ 0 →D+H- (H=K/Π) ... Waheed E. Et Al., E. Waheed, P. Urquijo, I. Adachi, H. Aihara, S. Al Said, D. M. Asner, H. Atmacan, V. Aulchenko, T. Aushev, S. Bahinipati, P. Behera, K. Belous, J. Bennett, M. Bessner, V. Bhardwaj, B. Bhuyan, T. Bilka, J. Biswal, A. Bobrov Jan 2022

Study Of B ¯ 0 →D+H- (H=K/Π) Decays At Belle Study Of B ¯ 0 →D+H- (H=K/Π) ... Waheed E. Et Al., E. Waheed, P. Urquijo, I. Adachi, H. Aihara, S. Al Said, D. M. Asner, H. Atmacan, V. Aulchenko, T. Aushev, S. Bahinipati, P. Behera, K. Belous, J. Bennett, M. Bessner, V. Bhardwaj, B. Bhuyan, T. Bilka, J. Biswal, A. Bobrov

Faculty and Student Publications

We present a measurement of the branching fractions of the Cabibbo favored B¯0→D+π- and the Cabibbo suppressed B¯0→D+K- decays. We find B(B¯0→D+π-)=(2.48±0.01±0.09±0.04)×10-3 and B(B¯0→D+K-)=(2.03±0.05±0.07±0.03)×10-4 decays, where the first uncertainty is statistical, the second is systematic, and the third uncertainty is due to the D+→K-π+π+ branching fraction. The ratio of branching fractions of B¯0→D+K- and B¯0→D+π- is measured to be RD=[8.19±0.20(stat)±0.23(syst)]×10-2. These measurements are performed using the full Belle dataset, which corresponds to 772×106BB¯ pairs and use the Belle II software framework for data analysis.

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The Influence Of An Acute Bout Of Aerobic Exercise On Vascular Endothelial Function In Moderate Stages Of Chronic Kidney Disease, Jeffrey S. Forsse, Zacharias Papadakis, Matthew N. Peterson, James Kyle Taylor, Burritt W. Hess, Nicholas Schwedock, Dale C. Allison, Jackson O. Griggs, Ronald L. Wilson, Peter W. Grandjean Jan 2022

The Influence Of An Acute Bout Of Aerobic Exercise On Vascular Endothelial Function In Moderate Stages Of Chronic Kidney Disease, Jeffrey S. Forsse, Zacharias Papadakis, Matthew N. Peterson, James Kyle Taylor, Burritt W. Hess, Nicholas Schwedock, Dale C. Allison, Jackson O. Griggs, Ronald L. Wilson, Peter W. Grandjean

Faculty and Student Publications

Chronic kidney disease (CKD) is directly influenced by the deleterious effects of systemic inflammation and oxidative stress. The vascular endothelium may transiently respond to aerobic exercise and improve post-exercise vascular renal function in moderate stages of CKD. Brachial artery flow-mediated dilation (FMD) is a nitric-oxide-dependent measure of endothelial function that is transiently potentiated by exercise. The purpose of the study was to determine the acute influence of a single bout of high-intensity interval exercise (HIIE) or steady-state moderate-intensity exercise (SSE) on endothelial dysfunction in moderate stages of CKD. Twenty participants (n = 6 men; n = 14 women) completed 30 …

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Performance Of Xor Rule For Decentralized Detection Of Deterministic Signals In Bivariate Gaussian Noise, Xingjian Sun, Shailee Yagnik, Ramanarayanan Viswanathan, Lei Cao Jan 2022

Performance Of Xor Rule For Decentralized Detection Of Deterministic Signals In Bivariate Gaussian Noise, Xingjian Sun, Shailee Yagnik, Ramanarayanan Viswanathan, Lei Cao

Faculty and Student Publications

In this paper, we consider the performance of exclusive-OR (XOR) rule in detecting the presence or absence of a deterministic signal in bivariate Gaussian noise. Signals, when present at the two sensors, are assumed unequal, whereas the noise components have identical marginal distribution but are correlated. The sensors send their one-bit quantized data to a fusion center, which then employs the XOR rule to arrive at the final decision. Here we prove that, in the limit as the correlation coefficient r approaches 1, the optimum fusion rule for both parallel and tandem topologies is XOR with identical, alternating partitions (XORAP) …

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Preparation, Evaluation, And Pharmacokinetics In Beagle Dogs Of A Taste-Masked Flunixin Meglumine Orally Disintegrating Tablet Prepared Using Hot-Melt Extrusion Technology And D-Optimal Mixture Design, Yangfeng Xu, Guoqing Yan, Xuemei Wen, Liqin Wu Jan 2022

Preparation, Evaluation, And Pharmacokinetics In Beagle Dogs Of A Taste-Masked Flunixin Meglumine Orally Disintegrating Tablet Prepared Using Hot-Melt Extrusion Technology And D-Optimal Mixture Design, Yangfeng Xu, Guoqing Yan, Xuemei Wen, Liqin Wu

Faculty and Student Publications

Flunixin meglumine (FM) is a nonsteroidal anti-inflammatory drug limited by irritation of the respiratory tract and mucosa in veterinary tissue. This study aimed to develop a taste-masked FM solid dispersion (SD) by hot-melt extrusion (HME) and formulate an orally disintegrating tablet (ODT) with selected excipients by direct compression. Eudragit® E PO was chosen as the matrix, and HME parameters were optimized: extrusion temperature, 135℃; screw speed, 100 rpm; and drug loading, 20%. Characterization techniques proved that FM was rendered amorphous in the HME extrudate. In vitro dissolution studies showed that FM SD released significantly slower than the corresponding physical mixture …

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Research News, Publications, 2022, Volume 4, Soumyajit Majumdar Jan 2022

Research News, Publications, 2022, Volume 4, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of October 1 through December 31, 2022

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Climate-Risk Materiality And Firm Risk, Ella Mae Matsumura, Rachna Prakash, Sandra C. Vera-Muñoz Jan 2022

Climate-Risk Materiality And Firm Risk, Ella Mae Matsumura, Rachna Prakash, Sandra C. Vera-Muñoz

Faculty and Student Publications

Managers are required to disclose material climate risk in Form 10-K, but their decision whether or not to disclose is confounded by the lack of consensus on whether climate risk is material to the firms, as well as uncertainty about enforcement of disclosure regulations. Using the SASB Materiality Map™ to proxy for market expectations of climate risk materiality, we test whether the association between disclosing climate risk in 10-Ks and firm risk (proxied by cost of equity (COE)) varies with market expectations of climate risk materiality. Using S&P 500 firms’ decisions whether to disclose climate risk in Form 10-K for …

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Integrating Machine Learning Algorithms With Quantum Annealing Solvers For Online Fraud Detection, Haibo Wang, Wendy Wang, Yi Liu, Bahram Alidaee Jan 2022

Integrating Machine Learning Algorithms With Quantum Annealing Solvers For Online Fraud Detection, Haibo Wang, Wendy Wang, Yi Liu, Bahram Alidaee

Faculty and Student Publications

Machine learning has been increasingly applied in identification of fraudulent transactions. However, most application systems detect duplicitous activities after they have already occurred, not at or near real time. Since spurious transactions are far fewer than the normal ones, the highly imbalanced data makes fraud detection very challenging and calls for ways to address it beyond the traditional machine learning approach. This study has proposed a detection framework, and implemented it using quantum machine learning (QML) approach by applying Support Vector Machine (SVM) enhanced with quantum annealing solvers. To evaluate its detection performance, we have further implemented twelve machine learning …

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Association Between Electronic Media Use, Development Milestones And Language In Infants, Maian Stamati, Lucas G. Gago-Galvagno, Stephanie E. Miller, Angel M. Elgier, Rocío A. Hauché, Susana C. Azzollini Jan 2022

Association Between Electronic Media Use, Development Milestones And Language In Infants, Maian Stamati, Lucas G. Gago-Galvagno, Stephanie E. Miller, Angel M. Elgier, Rocío A. Hauché, Susana C. Azzollini

Faculty and Student Publications

The use of electronic media has increased in early childhood. During early childhood, language and motor skills are important for the development of other cognitive skills. Therefore, it becomes essential to study how the use of screens is associated with these important skills in the first years of life. The objective of the following research was to describe the use of electronic media (i. e., TV, cellphone and tablet) and its association with language and developmental milestones in the first years of life. Participants were 253 primary caregivers of infants between 2 to 48 months (M = 30.17 months, SD …

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School Of Pharmacy Intellectual Property Report, Fy22, Third Quarter Report, Soumyajit Majumdar Jan 2022

School Of Pharmacy Intellectual Property Report, Fy22, Third Quarter Report, Soumyajit Majumdar

U. S. Patents, School of Pharmacy

No abstract provided.

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Digital Curation And Complex Decision Making: A School District’S Literacy Initiative, Sue Ann Sharma, Mark Edward Deschaine Jan 2022

Digital Curation And Complex Decision Making: A School District’S Literacy Initiative, Sue Ann Sharma, Mark Edward Deschaine

Faculty and Student Publications

Schools are in the process of incorporating professional development activities to prepare technology-proficient educators to utilize information and communication tools to meet the pedagogical needs of 21st-century students and learners. This research addresses the challenges of and preservation possibilities for the digital work of learning communities across instructional domains and levels. The digital curation efforts that support a school district’s literacy and curriculum initiatives are examined. We conclude with suggestions for future research, professional development, and practice.

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Design, Analysis, And Application Of Flipped Product Chaotic System, Md Sakib Hasan, Partha Sarathi Paul, Anurag Dhungel, Maisha Sadia, Md Razuan Hossain Jan 2022

Design, Analysis, And Application Of Flipped Product Chaotic System, Md Sakib Hasan, Partha Sarathi Paul, Anurag Dhungel, Maisha Sadia, Md Razuan Hossain

Faculty and Student Publications

In this paper, a novel method is proposed to build an improved 1-D discrete chaotic map called flipped product chaotic system (FPCS) by multiplying the output of one map with the output of a vertically flipped second map. Two variants, each with nine combinations, are shown with trade-off between computational cost and performance. The chaotic properties are explored using the bifurcation diagram, Lyapunov exponent, Kolmogorov entropy, and correlation coefficient. The proposed schemes offer a wider chaotic range and improved chaotic performance compared to the constituent maps and several prior works of similar nature. Wide chaotic window and improved chaotic complexity …

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Cascading Cmos-Based Chaotic Maps For Improved Performance And Its Application In Efficient Rng Design, Partha Sarathi Paul, Maisha Sadia, Md Razuan Hossain, Barry Muldrey, Md Sakib Hasan Jan 2022

Cascading Cmos-Based Chaotic Maps For Improved Performance And Its Application In Efficient Rng Design, Partha Sarathi Paul, Maisha Sadia, Md Razuan Hossain, Barry Muldrey, Md Sakib Hasan

Faculty and Student Publications

We present a general framework for improving the chaotic properties of CMOS-based chaotic maps by cascading multiple maps in series. Along with two novel chaotic map topologies, we present the 45 $nm$ designs for four CMOS-based discrete-time chaotic map topologies. With the help of the bifurcation plot and three established entropy measures, namely, Lyapunov exponent, Kolmogorov entropy, and correlation coefficient, we present an extensive chaotic performance analysis on eight unique map circuits (two under each topology) to show that under certain constraints, the cascading scheme can significantly elevate the chaotic performance. The improved chaotic entropy benefits many security applications and …

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Uv Exposure Causes Energy Trade-Offs Leading To Increased Chytrid Fungus Susceptibility In Green Tree Frog Larvae, Rebecca L. Cramp, Michel E. B. Ohmer, Craig E. Franklin Jan 2022

Uv Exposure Causes Energy Trade-Offs Leading To Increased Chytrid Fungus Susceptibility In Green Tree Frog Larvae, Rebecca L. Cramp, Michel E. B. Ohmer, Craig E. Franklin

Faculty and Student Publications

Levels of ultraviolet (UV) radiation have increased in many parts of the world due to the anthropogenic destruction of the ozone layer. UV radiation is a potent immunosuppressant and can increase the susceptibility of animal hosts to pathogens. UV radiation can directly alter immune function via immunosuppression and photoimmunotolerance; however, UV may also influence pathogen defences by affecting the distribution of energy resources among competing physiological processes. Both defence against UV damage and repair of incurred damage, as well as the maintenance of immune defences and responding to an immune challenge, are energetically expensive. These competing demands for finite energy …

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Use Of Real-Time Cadence To Prescribe Aerobic Physical Activity Intensity And Its Comparison With Existing Methods, Heontae Kim, Wei Sun, Mary Malaska, Bridget Miller, Ho Han Jan 2022

Use Of Real-Time Cadence To Prescribe Aerobic Physical Activity Intensity And Its Comparison With Existing Methods, Heontae Kim, Wei Sun, Mary Malaska, Bridget Miller, Ho Han

Faculty and Student Publications

The purpose of this study was to determine the effectiveness of physical activity intensity prescription using real-time cadence on achieving the required intensities for health benefits. Forty adults (18–65 years) participated in the study. The intensity prescriptions included Rating of Perceived Exertion, Talk Test, Heart Rate, and Real-Time Cadence. The participants performed a2-min trial for both moderate- and vigorous-intensity according to each prescription. Atri-axial accelerometer was used as acriterion measure. After completion of the trials, participant’s preference for the prescriptions was assessed by three domains (e.g., understanding, performing, maintaining). The compliance and achievement rates of RC were calculated and compared …

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Did2s: Two-Stage Difference-In-Differences, Kyle Butts, John Gardner Jan 2022

Did2s: Two-Stage Difference-In-Differences, Kyle Butts, John Gardner

Faculty and Student Publications

Recent work has highlighted the difficulties of estimating difference-in-differences models when the treatment is adopted at different times for different units. This article introduces the R package did2s which implements the estimator introduced in Gardner (2022). The article provides an approachable review of the underlying econometric theory and introduces the syntax for the function did2s. Further, the package introduces functions, event_study and plot_event_study, which uses a common syntax to implement all of the modern event-study estimators

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