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Articles 571 - 600 of 94607
Full-Text Articles in Entire DC Network
Icsb Poster Session, Ikhlas Khan
Icsb Poster Session, Ikhlas Khan
Oxford ICSB
Poster abstracts from the ICSB 2026 poster session.
The Use Of Nams To Screen For Developmental And Reproductive Toxicity (Dart) Of Botanicals, Cynthia Rider
The Use Of Nams To Screen For Developmental And Reproductive Toxicity (Dart) Of Botanicals, Cynthia Rider
Oxford ICSB
No abstract provided.
Botanical Safety Consortium: Overview And Progress, Connie Mitchell
Botanical Safety Consortium: Overview And Progress, Connie Mitchell
Oxford ICSB
No abstract provided.
Metabolomic Characterizations Of Hericium Erinaceus (Bull.) Pers. And Laricifomes Officinalis (Vill.) Kotl. & Pouzar Fungal Cultures, Kyle Meyer
Oxford ICSB
We present metabolomic characterizations of Hericium erinaceus (Bull.) Pers. (lion’s mane, yamabushitake, etc.), and Laricifomes officinalis (Vill.) Kotl. & Pouzar (syn. Fomitopsis officinalis; agarikon, eburiko, etc.) fungal cultures by high resolution orbitrap mass spectrometry and HPLC-DAD. Primary focus has been applied to the cultivation of these species on brown rice, Oryza sativa L., as a solid substrate. In the case of H. erinaceus, we have observed key differences in lipid metabolite profiles over a 28-day fermentation time series suggesting possible grain lipid feedstocks for fungal-derived lipid production, providing clear evidence of substrate biotransformation. For L. officinalis cultures, we observe distinct …
Bioactive Metabolite Markers For Functional Mushrooms: Comprehensive Metabolomic Mapping Of Full-Spectrum Cultivated Mushrooms, Standard Production And Method Development., Julie Daoust, Ivana Blaženović
Bioactive Metabolite Markers For Functional Mushrooms: Comprehensive Metabolomic Mapping Of Full-Spectrum Cultivated Mushrooms, Standard Production And Method Development., Julie Daoust, Ivana Blaženović
Oxford ICSB
Functional mushrooms are increasingly used in dietary supplements and functional foods, yet current scientific characterization of their chemistry remains limited by narrow extraction paradigms, limited standards availability and incomplete databases. In 2025, M2 Ingredients, in collaboration with Adikai Insights, completed a metabolomics atlas, a comprehensive untargeted metabolomics investigation of ten cultivated mushroom species grown under controlled indoor conditions in and effort to identify known bioactive molecules in whole mushroom samples to guide standard and quantitative method development targeting bioactive compounds present in the materials. Using high-resolution mass spectrometry and advanced cheminformatics, a total of 5,139 unique functional mushroom metabolites were …
Authenticated Hericium Erinaceus Mushroom And Selected Mycelia Reference Materials For General Industry Use, Steven Dentali
Authenticated Hericium Erinaceus Mushroom And Selected Mycelia Reference Materials For General Industry Use, Steven Dentali
Oxford ICSB
The establishment of authenticated reference materials is critical for method validation, standards development, and adulteration detection in the medicinal mushroom market. Hericium erinaceus (Lion’s Mane) is widely commercialized, yet historically has lacked species-specific analytical standards. This presentation describes the species identification protocol used by Nammex to develop and maintain authenticated H. erinaceus mushroom reference materials that support ongoing standards work, including advisory contributions to AOAC INTERNATIONAL initiatives. Production partner voucher specimens are authenticated using macroscopic, organoleptic, and morphological examination by qualified personnel, and retained as internal reference materials. Genetic verification using DNA sequencing confirms H. erinaceus identity in voucher specimens …
Determination Of Kratom Alkaloids In Botanical Products Using Multi-Criteria Lc–Ms Analysis, Mengliang Zhang
Determination Of Kratom Alkaloids In Botanical Products Using Multi-Criteria Lc–Ms Analysis, Mengliang Zhang
Oxford ICSB
Kratom (Mitragyna speciosa) is a botanical product widely sold in the United States as powders, capsules, tablets, gummies, and beverages. Natural kratom leaves primarily contain mitragynine (MG) as the dominant alkaloid. However, an increasing number of commercial products contain elevated levels of the more potent opioid alkaloid 7-hydroxymitragynine (7-OH) and the semi-synthetic compound mitragynine pseudoindoxyl (MGP). Reliable analytical identification of these compounds is critical for dietary supplement testing, regulatory monitoring, and public health protection. However, kratom matrices contain numerous structurally related alkaloids and isomeric compounds that complicate mass spectrometric identification and may lead to false positive assignments. The objective of …
Efficacy And Safety Of Red Ginseng Extract Powder (Kgc05pg) In Achieving Glycemic Control In Prediabetes Korean Subjects: A 12-Week, Single-Center, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study, Namhan Cho
Oxford ICSB
Background: This study was conducted to evaluate the efficacy and safety of Red Ginseng Extract Powder (RGEP) in achieving glycemic control in prediabetic Korean subjects. Methods: The study consisted of 49 subjects in the RGEP group and 49 in the placebo group. The participants were orally given 2 tablets of RGEP and placebo (500 mg/day twice daily in the morning and the evening within 30 min after meal), respectively. The subjects were followed duration of 12-week. The participants glycemic control parameters, such as fasting blood glucose levels, 30-, 60-, 90-, and 120-min blood glucose levels at 75gm oral glucose tolerance …
Ginsenoside-Based Theranostic Agents For Alzheimer's Disease: Implications For Brain Penetration, Cellular Uptake, And Anti-Aging Effects, Hak Soo Choi
Oxford ICSB
Red ginseng and its bioactive constituents, ginsenosides, have long been associated with neuroprotection and anti-aging effects, yet their limited ability to cross the blood-brain barrier (BBB) and poorly characterized biodistribution have hindered therapeutic translation. To address this, we developed a library of “ginsenoprobes” by conjugating major red ginseng components (Rg1, Rg3, Rb1, Rh2, Rk1, Rg5) and red ginseng extract (RGE) to a zwitterionic near-infrared (NIR) fluorophore (ZW800-1C), enabling real-time tracking of their fate in vitro and in vivo. All ginsenoprobes were purified to >95% homogeneity via preparative HPLC and rigorously characterized for optical properties, including molar extinction coefficients and dye-to-ginsenoside …
Metabolite Profiling Of Chamaelirium Luteum (False Unicorn) Roots And Related Commercial Products By Hptlc And Lc-Msms, Wendy Strangman, Wilmer Perera, Wilmer Perera
Metabolite Profiling Of Chamaelirium Luteum (False Unicorn) Roots And Related Commercial Products By Hptlc And Lc-Msms, Wendy Strangman, Wilmer Perera, Wilmer Perera
Oxford ICSB
Throughout history, medicinal plants have been used as herbal treatments in women’s health. However, they remain poorly characterized at the chemical level, limiting standardization and safety assessment. Chamaelirium luteum (false unicorn), traditionally used for reproductive health in the Eastern United States, has previously been shown to possess both conventional steroidal saponins as well as more rare open-chain saponins whose bioactivities are largely unexplored. Incorporation of C. luteum into commercial products, and subsequent overharvesting of wild populations has increased the urgency for robust methods to verify authenticity and detect adulteration. In this study, we coupled HPTLC-based profiling with detailed LC-MSMS analyses …
Hptlc: The New Front Line Of Global Botanical Surveillance, Tiên Do, Ilona Trettin, Ehab Mahran, Sonja Drobnjak
Hptlc: The New Front Line Of Global Botanical Surveillance, Tiên Do, Ilona Trettin, Ehab Mahran, Sonja Drobnjak
Oxford ICSB
Quality control of botanicals is approaching a breaking point. Regulators, industry, and pharmacists are now forced to answer questions faster and at larger scale than ever before: What plant is actually in the product? Is it the right species—or a look-alike? Is it pure or adulterated? Is it safe? Is the chemistry consistent? And how can labs make confident decisions when analytical capacity and staffing are finite? This presentation demonstrates how modern HPTLC— far beyond its historical role as a simple identity test— now provides clear, interpretable chemical evidence that supports analyst with a practical tool for risk-based surveillance of …
Advancements In Extraction And Co-Extraction Of Botanicals For Standardization And Efficacy, Rory Coleman
Advancements In Extraction And Co-Extraction Of Botanicals For Standardization And Efficacy, Rory Coleman
Oxford ICSB
Historically, botanicals have served human health in traditional medicine and supplementation due to their bioactive components. Efficient, clean extractions and clinical validation have become fundamental technologies, rendering access to libraries of efficacious products. However, cost, regulatory status, and speed to market have kept many botanicals in single or simple form. Mixtures of such single botanical extracts often require large quantities for effect, influenced by chemical composition, concentration, and delivery format. During the extraction and concentration process, exogenous "bioenhancers," e.g. piperine or oil blends for hydrophilic molecules, often become a necessity, exasperating the problem. Here, we will delve into the development …
Botanical Hepatotoxicity: Are We Accurately Characterizing Risk Vs. Hazard, Rick Kingston
Botanical Hepatotoxicity: Are We Accurately Characterizing Risk Vs. Hazard, Rick Kingston
Oxford ICSB
No abstract provided.
Yeast As A "Microbial Factory", Kaila Fuller, Betsy Jean Yakes
Yeast As A "Microbial Factory", Kaila Fuller, Betsy Jean Yakes
Oxford ICSB
Yeast are eukaryotic, single-celled microorganisms that are members of Kingdom Fungi, and in the world of dietary supplements, yeast qualify as a dietary ingredient as a botanical. During fermentation, yeast naturally produce byproducts that can be harvested, purified, and sold in a dietary supplement. Advances in biotechnology have allowed for genetic modification of yeast so that yeast can produce large quantities of native or non-native constituents during fermentation, effectively making yeast a “microbial factory” for various chemicals. Chemicals produced this way can qualify as a dietary ingredient as a constituent of a botanical. Relevant examples of past submitted notifications (public …
Jtc 26: Rethinking The Boundaries Of Pharmacy, Kylie Eggert
Jtc 26: Rethinking The Boundaries Of Pharmacy, Kylie Eggert
University of Mississippi News
This story is part of the 2026 Journey to Commencement series, which celebrates the pinnacle of the academic year by highlighting University of Mississippi students and their outstanding academic and personal journeys from college student to college graduate.
Jtc 26: A Community Builder With A Cause, Staff Report
Jtc 26: A Community Builder With A Cause, Staff Report
University of Mississippi News
This story is part of the 2026 Journey to Commencement series, which celebrates the pinnacle of the academic year by highlighting University of Mississippi students and their outstanding academic and personal journeys from college student to college graduate.
Jtc 26: Reading, Research And A Road To Medicine, Staff Report
Jtc 26: Reading, Research And A Road To Medicine, Staff Report
University of Mississippi News
This story is part of the 2026 Journey to Commencement series, which celebrates the pinnacle of the academic year by highlighting University of Mississippi students and their outstanding academic and personal journeys from college student to college graduate.
Jtc 26: Homeland Inspiration, Rebecca Lauck Cleary
Jtc 26: Homeland Inspiration, Rebecca Lauck Cleary
University of Mississippi News
This story is part of the 2026 Journey to Commencement series, which celebrates the pinnacle of the academic year by highlighting University of Mississippi students and their outstanding academic and personal journeys from college student to college graduate.
Researchers Show How Simple Magnets Can Help Solve A Complex Problem, Clara Turnage
Researchers Show How Simple Magnets Can Help Solve A Complex Problem, Clara Turnage
University of Mississippi News
OXFORD, Miss. – From cell phones to wind turbines and missile defense systems, modern technologies depend on critical minerals like rare earth elements. As demand grows, researchers are exploring more efficient and adaptable methods to recover and reuse these materials.
Using Natural Products In Patients With Cancer: More Than Chemotherapy, Gailen D. Marshall
Using Natural Products In Patients With Cancer: More Than Chemotherapy, Gailen D. Marshall
Oxford ICSB
The fundamental goal of cancer therapy is to cure the cancer. However, the approach to that goal is complicated and varies depending upon the type and stage of the tumor as well as the clinical characteristics of the patient. Cancer treatment focused on killing the tumor has considerable comorbidities associated with each therapy. Common side effects such as systemic immunosuppression, bleeding, anemia and specific organ-based pathologies each have their own significant morbidity/mortality risk. The use of natural products, both as direct antitumor agents and as moderators/mitigators of side effects of antitumor agents has a long history. Recent studies seek to …
Application Of Aqbd Principles To Build A Robust Compendial Analytical Method For The Quantification Of Phytochemicals In Mate And Guayusa Leaf Dietary Ingredients, Maria Monagas, Salika Jeelani, Greg Winter, Natalia Kouznetsova
Application Of Aqbd Principles To Build A Robust Compendial Analytical Method For The Quantification Of Phytochemicals In Mate And Guayusa Leaf Dietary Ingredients, Maria Monagas, Salika Jeelani, Greg Winter, Natalia Kouznetsova
Oxford ICSB
Mate (Ilex paraguariensis) and Guayusa (Ilex guayusa), both members of the Aquifoliaceae family, have traditionally been consumed as herbal teas in South America. Their leaves are rich in methylxanthines and hydroxycinnamoylquinic acids—quinic acid derivatives of caffeic and gregrferulic acids—which provide stimulant and antioxidant properties. These compounds make them valuable for use in health and energy beverages as well as dietary supplements. We applied the Analytical Quality-by-Design (AQbD) approach to develop a robust UHPLC method for simultaneous quantification of methylxanthines and hydroxycinnamoylquinic acids. The method and sample preparation were designed in alignment with USP General Chapter < 1220> Analytical Procedure Life Cycle and …
Windshield Not The Rearview Mirror, Dan Fabricant
Windshield Not The Rearview Mirror, Dan Fabricant
Oxford ICSB
We talk a great deal about the past at ICSB and while the history is important, we still need to skate to where the puck is going. We’ll tee up where we are and where we are going when it comes to: drug preclusion; federal preemption; state regulatory efforts; hemp/cannabis; electronic commerce platforms; claims; essentiality; and much more, like what you can do to affect real change for the future of the industry.
A Joint Effort: Accomplishments Of The Resource Center For Cannabis And Cannabinoids Research, Patrick Still, Don Stanford, Mary Paine, Nandakumara Sarma
A Joint Effort: Accomplishments Of The Resource Center For Cannabis And Cannabinoids Research, Patrick Still, Don Stanford, Mary Paine, Nandakumara Sarma
Oxford ICSB
No abstract provided.
Um School Of Education Honors Hall Of Fame Inductees, Practitioners Of Distinction, Don Feitel
Um School Of Education Honors Hall Of Fame Inductees, Practitioners Of Distinction, Don Feitel
University of Mississippi News
OXFORD, Miss. – The University of Mississippi School of Education recognized nine alumni and educators for their ongoing contributions to the field of education.
Jtc 26: Biology Major Builds Confidence, Community Through Gospel Choir, Srijita Chattopadhyay
Jtc 26: Biology Major Builds Confidence, Community Through Gospel Choir, Srijita Chattopadhyay
University of Mississippi News
This story is part of the 2026 Journey to Commencement series, which celebrates the pinnacle of the academic year by highlighting University of Mississippi students and their outstanding academic and personal journeys from college student to college graduate.
Jtc 26: Finding Self Through The Lens, Srijita Chattopadhyay
Jtc 26: Finding Self Through The Lens, Srijita Chattopadhyay
University of Mississippi News
This story is part of the 2026 Journey to Commencement series, which celebrates the pinnacle of the academic year by highlighting University of Mississippi students and their outstanding academic and personal journeys from college student to college graduate.
Um Joins Regional Universities To Create Mid-South Ai Consortium, Clara Turnage
Um Joins Regional Universities To Create Mid-South Ai Consortium, Clara Turnage
University of Mississippi News
OXFORD, Miss. – With the signing of a new regional agreement today (April 20), the University of Mississippi is joining forces with partner institutions to position the Mid-South as a national hub for applied artificial intelligence research.
Jtc 26: Making The Leap From Patient To Provider, Emily Howorth
Jtc 26: Making The Leap From Patient To Provider, Emily Howorth
University of Mississippi News
This story is part of the 2026 Journey to Commencement series, which celebrates the pinnacle of the academic year by highlighting University of Mississippi students and their outstanding academic and personal journeys from college student to college graduate.
Jtc 26: Transfer Student Discovers Full Potential At Ole Miss, Emerson Penny
Jtc 26: Transfer Student Discovers Full Potential At Ole Miss, Emerson Penny
University of Mississippi News
This story is part of the 2026 Journey to Commencement series, which celebrates the pinnacle of the academic year by highlighting University of Mississippi students and their outstanding academic and personal journeys from college student to college graduate.
Math In Melody: How Music Strikes A Chord With Memory And Learning, Aidan V. Waters
Math In Melody: How Music Strikes A Chord With Memory And Learning, Aidan V. Waters
Honors Theses
As a result of personal curiosity, this thesis seeks to understand the current status of music integration within educational settings, discussing its importance and potential impact. By considering existing literature, it analyzes music’s effectiveness in K-12 education, particularly within the mathematics classroom. Based on the current body of research, the study identifies three key features of music integration: its effectiveness as an energizer, a memory tool, and a means of creating structure within the classroom. Building on these findings, a proposed ten-day, music-integrated Algebra I unit on functions is presented, applying the research in a variety of ways. The unit …