Digital Commons Network^™

Descriptive Analysis: Effects Of Insufficient Sleep Among College Students Ages 18-22, Divine Ighalo

Honors Theses

Background: Not getting enough sleep is common among college students and is often linked to habits such as screen time, caffeine intake, stress, and irregular routines. This study examined how these lifestyle factors are associated with insufficient sleep among college students ages 18-22 and how poor sleep affects their overall wellbeing. Methods: This study used a cross-sectional survey design and collected data through an anonymous 25 question online Qualtrics questionnaire. This was completed by 150 participants. The survey was designed to be completed in about 5-7 minutes. It included a mix of multiplechoice questions, frequency-based responses and select all that …

Use Of Electroencephalography To Evaluate Neural Correlates Of Attention In The Oddball Paradigm, Folsom J. Berry

Honors Theses

Electroencephalography (EEG) and Event-Related Potentials (ERP) are tools used to study and analyze cognitive processing. EEG measures neuroelectric brain activity from the scalp, while ERPs are time-locked averages that are used to isolate neural responses to stimuli. The P300 (P3) component (positive waveform elicited at 300 milliseconds (ms)) is the primary ERP component. This thesis project had two main objectives. The first objective was to develop conceptual and technical competency in EEG/ERP theory, data acquisition, and processing. The second objective was to implement the visual oddball paradigm through experimental demonstration. This experiment tested the hypothesis that infrequent target stimuli will …

The Impact Of Palm Cooling On The Physiological And Cognitive Function Of Aerobically Trained Individuals, Katherine L. Tibbs

Honors Theses

Background: Cooling strategies have been shown to combat the harmful effects that an increase in body temperature can potentially cause, and palm cooling in particular has been adopted due to its effectiveness in mitigating muscle fatigue during exercise. While there is clear support that this improves muscular strength and endurance, there is a lack of research on the impact palm cooling has on the mental aspect of physical activity. The purpose of this study was to investigate the cognitive and physiological effects of palm cooling on aerobic exercise performance. Methods: Ten aerobically trained participants between the ages of 18-35 were …

Ccr5 Sulfopeptide Library And O-Glycosylated Amino Acids As Chemical Tools For Probing Chemokine Receptor Recognition, Mostafa Mohammed Mohammed Ali Eldeen

Electronic Theses and Dissertations

Chemokine-receptor interactions play a central role in immune regulation and disease pathogenesis, particularly through CCR5, a receptor engaged by chemokines such as CCL3, CCL4, and CCL5. Post-translational modifications of the CCR5 N-terminus—including tyrosine sulfation at positions 3, 10, 14, and 15, and O-glycosylation at serine 6—critically modulate chemokine recognition and selectivity. However, the impact of specific sulfation patterns on chemokine binding and the synergistic effects of combined sulfation and glycosylation remain incompletely understood. This thesis presents a two-project chemical approach to systematically investigate CCR5 post-translational modifications. In Project 1, a comprehensive 16-member library of CCR5???? sulfopeptides representing all possible combinations …

A Revised Quantifier Variance And Its Implications On Vagueness, Isaac Alexander Huling

Electronic Theses and Dissertations

This paper argues that the Special Composition Question has no substantive answer, not because compositional talk is empty but because the physical structure it tracks does not have the form that would privilege a unique answer. The argument accepts Sider’s methodological premise that the world must provide structure beyond description if ontological vocabulary is to mean anything, and deploys that apparatus against his specific application of it to composition. Constraint processes among a system’s parts – the forces and interactions that hold rigid bodies together, maintain organisms, bind solar systems – satisfy every condition Lewis required of reference magnets. They …

Staying In Stem?: A Qualitative Exploration Of Women’S College Classroom Experiences In Stem Education, Sarah Dapaah

Electronic Theses and Dissertations

Women leave STEM not because of a lack of ability, but because of the classroom and institutional conditions they encounter once they arrive. This study examines how classroom experiences shape women’s decisions to persist in or leave STEM majors at the college level. Drawing on the sociological frameworks of doing gender, gendered organizations, and intersectionality, this study explores how gender, race, and class shape women’s experiences of belonging, support, discouragement, and recognition in STEM. Using 21 semi-structured interviews and 4 classroom observations at the University of Mississippi, the study analyzes the experiences of undergraduate women who remained in STEM, women …

“Con Ăn Cơm Chưa?” (“Have You Eaten Yet?”): Foodways, Identity, And Generational Place-Making For Vietnamese Women In Memphis, Alana Freimanis

Electronic Theses and Dissertations

This qualitative study examines the role of food within community tactics for mobilization and negotiation. In order to do so, this study employs a mixed-methods approach of semi-structured interviews, participant observations, and archival analysis, to answer questions around how participants subvert historically racialized narratives around Vietnamese immigrant’s labor, family, and identity. Specifically, how do Vietnamese American women in Memphis use food labor to negotiate racialized immigrant identities and mobilize cultural and community power within the constraints of gendered expectations, class position, and racial stereotypes? Furthermore, this research focuses on Vietnamese women’s positionality, centering women chefs and community leaders as the …

Health And Care: Childhood Among The Classic Period Maya At Buenavista Del Cayo, Belize, Lindsey Hall

Electronic Theses and Dissertations

Three deposits of perinates, infants, and young children within two non-residential superstructures of Buenavista del Cayo, Belize, display evidence of daily maintenance and care. A total of ten subadult individuals, aged 39.4 weeks gestation to 3 years, from the archaeological site of Buenavista were recovered during 2018 excavations. Signs of care and daily maintenance include survivorship through the vulnerable neonatal period (first twenty-eight days) and transition into infancy, survivorship with potential pinprick lesions on external and internal zygomatic, parietal, and pars basilaris, and intentional maintenance of the body after death. Identification of care and daily maintenance at Buenavista informs the …

Connecting The Dots: Hbcus, Access To Ai Education, And The Realities Of Public-Private Collaboration, Whitney Wells

Electronic Theses and Dissertations

As artificial intelligence (AI) continues to reshape workforce demands and educational priorities, this partnership has emerged as a potentially effective mechanism for advancing equitable access to emerging technologies. However, limited research has explored how and why diverse organizations engage in such collaborations, particularly in regions facing persistent educational and economic disparities. This study examines the organizational motivations driving participation in the Mississippi AI Collaborative (MAIC), a multi-sector partnership involving a higher education institution, industry partners, nonprofits, and a K-12 system. While the MAIC focuses specifically on AI education and training, the purpose of this study is not to examine AI …

Invisible: An Autoethnographic Study Of Teaching And Learning With Physical Disabilities And Neurodivergence, Amanda Josephine Austin Goodwin

Electronic Theses and Dissertations

In this autoethnographic study, vignettes of a female high school teacher and graduate student with invisible disabilities are analyzed through the lens of Critical Disability Theory. This study provides teachers, administrators, and policy makers with a first-hand account of some of the barriers individuals with invisible disabilities face. Policies, environments, and practices in K-12 education, higher education, and broader society are analyzed. Advancements in inclusivity and accessibility as well as improvements in teacher education programs are suggested. Reflection throughout this study, three core themes emerged: listen, believe, and support individuals with invisible disabilities.

Exploring Mississippi Valley State University’S First-Year Experience Program: Students’ Perceptions Of Its Impact On Their Sense Of Belonging, Jordan Freeman

Electronic Theses and Dissertations

Colleges and universities have a primary goal of providing quality education to their students with the hope that those students go on to make positive contributions to society. While many people tend to credit classroom learning for those societal contributions, an argument can be made that supplementary experiences are just as valuable. At Mississippi Valley State University (MVSU), a small, public Historically Black College/University in the Mississippi Delta area, student engagement initiatives are of extreme importance for first-year students. Students at MVSU face several challenges including college readiness, ability to afford college, and desire to persist and earn their degrees. …

Institutional Strain And Substance Coping: Analyzing Perceived Racial Discrimination As A Predictor Of Adolescent Marijuana Use, Fahad Bin Islam Khan

Electronic Theses and Dissertations

This study examines the relationship between perceived racial/ethnic discrimination, psychological distress, and youth marijuana consumption through the lens of the General Strain Theory. It uses the complete-case sample from the 2023 Youth Risk Behavior Survey (YRBS), which surveyed 17,268 high school students across the United States, in a cross-sectional study. The study used logistic regression analyses to assess the association between perceived racial or ethnic bias (e.g., actual discriminatory experiences), psychological distress, and substance use (marijuana), and how closely emotional stress linked these two phenomena. The results indicate that perceived discrimination has a significant positive association (greater likelihood) with both …

Adversarial Llm-Gans For Robust Synthetic Pharmaceutical Data In Self-Emulsifying Drug Delivery Systems, Samiul Islam Niloy

Electronic Theses and Dissertations

The formulation of self-emulsifying drug delivery systems (SEDDS) represents a pivotal advancement in improving the oral bio-availability of poorly water-soluble pharmaceutical compounds, yet traditional development is heavily hindered by limited experimental datasets and the complexity of predicting key quality attributes like nanoparticle size and drug release profiles. Because empirical methodologies struggle to balance formulation constraints with predictive accuracy, this research introduces a comprehensive framework that leverages state-of-the-art generative artificial intelligence to synthesize realistic, constraint-compliant SEDDS datasets. The study proposes two primary methodologies to overcome data scarcity: a novel Drug Formulation Agent (DFA) powered by Large Language Models (LLMs) and a …

Computational Modeling Of Lamina Cribrosa Biomechanics, Lydia Schwartz

Electronic Theses and Dissertations

The lamina cribrosa is a critical structural component of the optic nerve head and is believed to play a central role in the development of glaucoma. Understanding how its geometry and microarchitecture influence the mechanical behavior is essential for improving computational models of the optic nerve head. However, the complex structure of the lamina cribrosa presents a difficult challenge for experimental and computational investigations. In this study, two computational modeling approaches were developed to investigate the influence of structural representation on lamina cribrosa biomechanics. A curvature-based continuum model was used to examine the effects of the anterior surface geometry, parameterized …

Development And Evaluation Of Ros-Responsive Thioketal-Capped Mesoporous Silica Nanoparticles For Dual Drug Delivery Of Moxifloxacin And Curcumin In Wound Healing, Saiganesh Pothuraju

Electronic Theses and Dissertations

Chronic infected wounds remain a major clinical challenge because elevated reactive oxygen species (ROS) in the wound microenvironment sustain inflammation, damage regenerating tissue, and limit the effectiveness of conventional antimicrobial and anti-inflammatory therapy. To address this problem, this study aimed to develop ROS-responsive thioketal-capped mesoporous silica nanoparticles (TK-MSNs) for the dual delivery of moxifloxacin (MOX) and curcumin (CUR) to support the management of infected wounds. Mesoporous silica nanoparticles (MSNs) were synthesised using tetraethyl orthosilicate (TEOS) and cetyltrimethylammonium bromide (CTAB), followed by template removal, amino-functionalization with 3-aminopropyltriethoxysilane (APTES), and sequential loading of MOX and CUR. ROS-responsive capping was then achieved using …

With Equity And Inclusivity For All: Self-Reported Preparedness Of Band Directors To Teach Students With Exceptional Needs, Kendra Jenkins Lee

Electronic Theses and Dissertations

The traditional memory theory of personal identity relies on an implicit storage model of memory to explain how the self persists over time. This model assumes that memories endure as stable representations that can be accurately retrieved, and that such representational continuity grounds diachronic identity. However, contemporary cognitive science demonstrates that remembering is an active and reconstructive process. Each act of recall reorganizes and transforms prior experience during the window of ecphory. This reconstructive reality poses a significant philosophical challenge. If memory is inherently unstable and transformable, it cannot straightforwardly ground the kind of continuity the theory requires.

In this …

The 6th United States Volunteer Infantry: The Last Of The Galvanized Yankees, Seth Ihde

Electronic Theses and Dissertations

This thesis examines the formation, service, post-war life, and impact of the 6th United States Volunteer Infantry Regiment. This regiment and the five preceding it consisted of Confederate POWs who enlisted in the Union Army between 1864 and 1865. The project intersects with a few different historiographies, including Confederate nationalism/dissent and the military’s role in westward expansion. The 6th was formed from soldiers in Camp Douglas, Illinois, Camp Morton, Indiana, and Camp Chase, Ohio. The soldiers were predominantly young and poor southern farmers. These men represent a form of southern dissent to Confederate nationalism and the claims of the Lost …

Physicochemical Interactions At The Ionic Liquid-Polymer-Biological Nanointerface, Sara Xuan Edgecomb

Electronic Theses and Dissertations

Treatment of central nervous systems (CNS) disorders remains a critical challenge in drug delivery. The blood brain barrier (BBB) is an obstacle preventing targeted delivery. Small and large drug molecules are unable to cross the BBB, highly limiting drug therapies. Only invasive techniques and symptom care are currently employed for neurological diseases.

This demands an innovative drug delivery approach to improve efficiency of targeted delivery to the brain, hence polymeric nanoparticles (NPs) being a promising solution. With their advantageous tunability, they can encapsulate various biomolecules and perform specific targeting. Ionic liquids (ILs) have become a novel surface modification of NPs …

The Tugaloo Effect: Preliminary Analyses Of Population Genomics And Parasitism In Salamanders Of Northeast Georgia, Tyler Lewis Brock

Electronic Theses and Dissertations

The Tugaloo River is a 50-mile-long stretch of river that serves as an important political and biogeographical boundary in far northeastern Georgia and northwestern South Carolina. The extreme topography, complex geological and hydrological history, and unique assemblage of soils, flora, and fauna of the Tugaloo region make it a prime candidate for study. I used the diverse salamander community there to conduct two studies. Study 1 investigated how the population genomics of select species in the genera Desmognathus and Plethodon were impacted by ancient drainage modifications from the Pleistocene which included not only the Tugaloo River but also the Tallulah, …

Foundations And Scope Of Moral Standing, Vikas Beniwal

Electronic Theses and Dissertations

This thesis investigates the foundational grounds of moral standing. I contend that sentience, while frequently cited as the primary criterion, lacks sufficient justification when asserted as a necessary condition. I propose an alternate feature as sufficient grounds of moral standing.

Jtc 26: Creative Writing Graduate’S World Revolves Around Faith And Fantasy, Benita Whitehorn

University of Mississippi News

This story is part of the 2026 Journey to Commencement series, which celebrates the pinnacle of the academic year by highlighting University of Mississippi students and their outstanding academic and personal journeys from college student to college graduate.

Mississippi Coastal Bacterial Community Response To Lowered Salinty, Jackson C. Sues

Honors Theses

Microbial communities are essential to the function of coastal ecosystems; however, few studies have examined their response to short-term reductions in salinity. This study used a microcosm approach to examine how decreased salinity over five days affected seawater bacterial community composition, diversity, and richness. Microcosms were assigned to three treatments: unmanipulated seawater (control) collected from the Mississippi coast, seawater amended with natural freshwater, and seawater amended with sterilized freshwater. Length of time bacteria spent in the microcosms was found to have the strongest effect on bacterial community composition, while salinity effects were weaker but still statistically significant. All treatments shifted …

Multi-Omics Systems-Guided Insights Of Withanolide And Other Bioactives Contributions To Anti-Stress And Endurance Outcomes In Withania Somnifera, Deepak Mundkinajeddu

Oxford ICSB

Conventional Ashwagandha standardization is largely focused on total withanolide quantification, without insights on the functional contribution of other phytochemical fractions. In this discovery-driven development program, orthogonal array–based model combined with predictive transcriptomics was used to delineate the relative biological roles of withanolide and other bioactive components within Withania somnifera extracts. Validated animal models showed that withanolide-enriched fractions significantly reduced serum cortisol (p< 0.05), while other bioactive-enriched fractions significantly increased run-time to exhaustion (p< 0.05), confirming anti-stress and endurance mechanisms. By linking the phytochemical profile with predicted biological pathway activity, the composition of the extract is rationally optimized for the development of a standardized extract (Ashwa.30), designed to deliver both anti-stress and endurance benefits at a dose of 30 mg. Clinical evaluation of the Ashwagandha extract demonstrated significant reductions in perceived stress scores and circulating cortisol levels, alongside measurable improvements in endurance parameters compared to placebo (p< 0.05), confirming translational alignment from preclinical discovery to human outcomes. Untargeted metabolomic profiling revealed enrichment of glycine and serine metabolism, methionine metabolism, phenylalanine and tyrosine metabolism, and homocysteine degradation pathways. These integrated metabolic changes worked together to improve energy production, support mitochondrial repair, maintain antioxidant balance, and help reset the body’s stress response system. This work presents a systems-biology–based approach to holistic Ashwagandha standardization, integrating withanolides and complementary bioactivities. It establishes a precision-driven framework for clinically validated adaptogenic efficacy.

Alkaloid Profiling Of Narcissus Poeticus L. Bulbs And Their Inhibitory Activity Of Cholinesterases, Maël Gainche, Isabelle Ripoche, Elodie Jagu

Oxford ICSB

The Amaryllidaceae family is well known for its rich diversity of alkaloids, including lycorine- and galantamine-type structures with potent cholinesterase inhibitory properties. In this study, we investigated the phytochemical composition and cholinesterase inhibitory activity of alkaloids isolated from Narcissus poeticus L., a species native to the botanically rich Auvergne region of France. Phytochemical analysis and bioguided fractionation of bulb extracts led to the identification of three known alkaloids, pseudolycorine, norgalantamine, and 2-O-(3’-hydroxybutanoyl)-lycorine, as well as a newly characterized tetrahydroquinoline derivative, poeticine A. The inhibitory activities of these compounds against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) were assessed using both a standard …

Evaluation Of Fasted And Fed Gastrointestinal Transformation Of Withania Somnifera Plant Extracts And Bioactive Compounds Via Uplc-Ms/Ms And Untargeted Metabolomics, Sarah Barr, Wendy Strangman, R. Thomas Williamson, Amala Soumyanath, Melissa Bollen

Oxford ICSB

Ashwagandha (Withania somnifera) is a widely consumed botanical supplement recognized for its anti-inflammatory, antioxidant, and anti-aging properties. Despite its extensive use, limited information exists on how its complex chemical composition changes during gastrointestinal digestion. An untargeted UPLC-MS/MS-based metabolomics approach enables analysis of discrete changes in complex mixtures. Previous in vitro studies of W. somnifera relied on simulated gastric and intestinal models composed primarily of buffers and digestive enzymes. This study advances those methods by incorporating bile salts and phospholipids under fasted and fed conditions to better simulate physiological digestion of aqueous and ethanolic extracts of W. somnifera root and leaf. …

Unmasking Ashwagandha Controversy: Safety, Toxicity, And Adulteration, Tahir Maqbool Mir

Oxford ICSB

Ashwagandha (Withania somnifera) is an adaptogenic shrub valued for its roots, which support systemic health. Increasing use has raised safety concerns about adulteration and hepatotoxicity. The roots of ashwagandha are primarily preferred for systemic health, while the leaves were traditionally reserved for topical applications to treat joint inflammation and promote wound healing.  Although generally considered safe, ashwagandha supplements have been linked to drug-induced liver injury, including cholestasis, jaundice, and pruritus. Reports from various organizations like LARB in the Netherlands indicate a rise in liver toxicity cases, possibly due to cytotoxic withafrin A and DNA-damaging withanone. A major concern is widespread …

Determinants Of Opioid-Relevant Exposure From 7-Hydroxymitragynine Products In The Evolving U.S. Marketplace, Igor Koturbash, Scott Alsbrook, George Pro

Oxford ICSB

Kratom’s U.S. market has rapidly evolved from largely botanical powders and capsules to products enriched in 7-hydroxymitragynine (7-OH), a potent mu-opioid receptor agonist that is typically present only at trace levels in leaf material. To quantify downstream behavioral health burden and contextualize it with real-world signals of product diffusion, we analyzed National Survey on Drug Use and Health (NSDUH) data (2021-2023) alongside public health alert trends and systematic online product surveillance. In NSDUH, 5.8% of adults met criteria for serious mental illness (SMI). SMI increased by 150% among adults with combined opioid use disorder (OUD) and kratom use between 2021 …

Natural Products As Multi Drug-Multi Target Therapeutics - From The Pharmacological Proof To New Approaches For Quantitative Quality Control, Olaf Kelber

Oxford ICSB

In the two decades since the mode of action of herbal medicinal products has been characterized as the Multi Target action of Multi Drug combinations [1,2, 3], the body of evidence supporting the general applicability of this principle to herbal health products has been exponentially increasing.  Key studies describing this principle, based on a wide range of pharmacological models, have been conducted in STW 5 and STW 5-II, herbal combinations used in the treatment of disturbances of the gut-brain interaction (DGBIs) as e.g. upset stomach and irritable bowel syndrome [2, 4]. They allow to characterize the contribution of each combination …

Medicinal Plants And One Health Drug Discovery: Plectranthus Abietanes As P-Glycoprotein Modulators, Patricia Rijo

Oxford ICSB

Cancer remains a major global health challenge, with multidrug resistance (MDR)—frequently driven by P-glycoprotein (P-gp) overexpression—significantly limiting the effectiveness of chemotherapy. Within a One Health perspective, Africa, home to five major medicinal biodiversity hotspots, represents an underexplored reservoir for natural products–based drug discovery. Among this rich flora, the genus Plectranthus (Lamiaceae) emerges as a particularly promising source of bioactive abietane diterpenes. In this work, the abietane diterpene 7α-acetoxy-6β-hydroxyroyleanone (Roy), isolated from Plectranthus grandidentatus Gürke, exhibited pronounced cytotoxic activity against several cancer cell lines. To enhance its pharmacological profile, a series of Roy ester derivatives was synthesized and evaluated for their …

Expanding Natural Product Diversity Through Biotransformation, Emerson Queiroz

Oxford ICSB

Over the past decade, natural product research has undergone a methodological revolution [1]. Modern approaches now integrate advanced metabolite profiling techniques for compound annotation and prioritization, together with high-resolution chromatographic methods that enable seamless transition from analytical to preparative scales [2]. These tools have facilitated the detection and identification of minor bioactive constituents. Nevertheless, plant extracts typically contain abundant common scaffolds with limited relevance for drug discovery. In this context, enzymatic biotransformation emerges as a promising strategy to enhance chemical diversity and unlock new structural space. Two complementary biotechnological approaches have been developed: enzymatic transformation using fungal secretomes (crude extracellular …