Digital Commons Network^™

Mapping In/Exclusion: Queer Identity In Oxford, Mississippi, Julia Kraus

Electronic Theses and Dissertations

This thesis employs a mixed methods approach to investigate LGBTQ communities in Oxford, Mississippi, within the unique context of the Bible Belt panopticon. Through an examination of the Unitarian Universalist Congregation of Oxford (UUCO) and Oxford Pride, the study delves into the themes of visibility and surveillance, resistance and subversion, community and identity, and institutional interactions and impacts. The research is grounded in seven original interviews with UUCO members, providing nuanced insights into the functioning of LGBTQ communities within a conservative environment. Additionally, the creation of a podcast episode titled “Queering Oxford: the Long Path to Pride” offers an innovative …

Evaluation Of Process Parameters For Continuous Manufacturing Of Quetiapine Fumarate Immediate Release Tablets Using Twin Screw Wet Granulation, Tejaswini Naguboyina

Electronic Theses and Dissertations

Granulation is one of the important unit operations in the manufacturing of solid dosage forms like tablets and capsules that regulate the quality of end products. It is a process of particle enlargement by agglomeration technique, which improves flow properties, compressibility, reduction of dust formation, drug content uniformity, dissolution rates, and overall product stability. Traditionally, it has been a batch process due to a better understanding. However, there has been a shift towards continuous manufacturing using a Twin-screw granulator, which is more robust, scalable, and versatile for various applications. This work presents the use of Twin screw wet granulation (TSWG) …

Montesquieu: The Nature Of L’Esprit Des Lois, Christian Jax Murray

Electronic Theses and Dissertations

When Baron de Montesquieu received a copy of his L’Esprit des lois, he was horrified by the total removal and reorganization of critical parts of his text, changed ideas, and an abnormal amount of printing errors in his work. While he saw these issues hindering the reception of his work, this thesis argues that the chaos of the text, in both its style and publication, made the book more popular instead of hindering it. Montesquieu, his editor, and his publisher constructed a new kind of text that was broad in its subject matter and ambiguous in its meaning where its …

Modeling The Relationship Between Protein Sequence And Structure Using Triangular Spatial Relationship-Based Keys, Arianna Nicole Swensen

Electronic Theses and Dissertations

Protein structure comparison and our understanding of protein sequence and structure relationships are intertwined. In this work, I use the TSR-based key generation algorithm to develop a model for relating sequence and structure. I develop embeddings for the sequence-based keys and the structure-based keys as the basis for a translation model between the two sets of keys, evaluating the efficacy of local and global embedding generation techniques in the context of the TSR-based comparison method.

Investigation Of Evolution In Fungal Traits At Multiple Genetic Scales, Brooke Allen

Electronic Theses and Dissertations

The study of fungal traits is critical for understanding community assembly and ecosystem function, as traits related to resource acquisition, enemy avoidance, and stress tolerance link fungi to their ecological roles. Symbiotic relationships, such as those between ectomycorrhizal (EcM) fungi and their host plants, greatly influence fungal traits and play a key role in fungal evolution. In this study, we addressed the evolution of EcM fungal traits, particularly biosynthetic gene clusters (BGCs), at multiple genetic scales, including individual genes, genotypes within populations, and a broader phylogenetic perspective across the fungal kingdom. First, we surveyed the diversity of BGCs in native …

Development Of Multiple Dosage Forms Using Fused Deposition Modeling 3d Printing Coupled With Hot-Melt Extrusion Dissertation, Peilun Zhang

Electronic Theses and Dissertations

This dissertation explores the integration of Hot Melt Extrusion (HME) and Fused Deposition Modeling (FDM) 3D printing as a novel continuous manufacturing process for pharmaceutical dosage forms. Emphasizing the creation of personalized and complex drug delivery systems, this work highlights the potential of 3D printing technology in revolutionizing pharmaceutical manufacturing by offering customized dosage, precise API distribution, and efficient production with minimal waste. The first chapter delves into the fabrication of bilayer tablets utilizing HME in conjunction with dual-nozzle FDM 3D printing, examining the mechanical properties of HME filaments and the printing quality through a novel 3D printed tablet retention …

A Case For Digital Coaches, Elise Brown

Electronic Theses and Dissertations

In response to COVID-19, the Mississippi Department of Education (MDE) invested approximately $295 million to support digital learning efforts. This investment, referred to as the Mississippi Connects Initiative, funded state level infrastructure improvement, bulk device purchasing, digital subscription purchasing, telehealth and teletherapy resources, and professional learning for educators. Focusing on professional learning, this study aimed to determine if differences existed between schools that did and did not receive professional learning via the digital learning coaching program.

The data used in this study was collected in the spring of the 2021-2022 and 2022-2023 school years, using the BrightBytes® Technology and Learning …

Vascular Adaptations To Single Sprint Training, Matthew Alexander Chatlaong

Electronic Theses and Dissertations

Background: Recent sprint interval training studies suggest cardiorespiratory fitness improves after training with 2 x 20s but not 1 x 20s. While insufficient for improving whole-body cardiorespiratory fitness, vascular function or other components of cardiorespiratory fitness may improve. It is unknown if brief intense exercise bouts are sufficient for improvements in these outcomes. This initial exploratory work investigated these outcomes to facilitate future research in this area. Purpose: Investigate changes in micro- and macro-vascular function in young, untrained adults following 4-weeks of single sprint training. Methods: 46 healthy, untrained participants ages 18-35 were allocated to either a training or time-matched …

Polymer Coated Microneedles, A Novel Technology For Drug Delivery And Sampling, Deeksha Jakka

Electronic Theses and Dissertations

Microneedles are used to deliver drugs to the skin and the mucous membrane. Soluble polymers are used to make soluble microneedles; these polymers instantly dissolve in the tissue and release their entire drug load, including the polymer construct. To reduce the severity of side effects at the site of administration and systemic unfavorable effects, it is often better for the drug to release slowly into the tissue. Furthermore, it is safe and effective to release the active pharmaceutical ingredient (API) under controlled release, excluding the excipients.

In the first chapter, Polymer-Coated Polymeric (PCP) microneedles were fabricated using PVP K 30 …

Small Organic Molecules Absorbing Low Energy Photons For Dye Sensitized Solar Cells And Biological Imaging, Ravinder Kaur

Electronic Theses and Dissertations

Small organic molecules with the ability to access photons at longer wavelengths are greatly needed in the fields of dye sensitized solar cells and biological imaging. Firstly, an urgent challenge limiting the improvement in photocurrent of dye-sensitized solar cell (DSC) technology is the availability of chromophores capable of harvesting the full spectrum of solar irradiation and the judicious employment of these chromophores with other components of the DSC device in order to achieve higher efficiencies. Therefore, strategies are put forward to fabricate and optimize the DSC devices by using novel cross conjugated organic photosensitizers based on benzo[b]thiophene and fused dibenzosilin …

A Quantitative Study Of The Effectiveness Of The University Of Mississippi's Biology Bootcamp, Nicole Lewis

Electronic Theses and Dissertations

There is a growing demand for a Science, Technology, Engineering, and Mathematics (STEM) trained workforce in the United States. In order to remain globally competitive, the US needs to increase the STEM workforce not only in numbers but also diversity. Colleges and universities throughout the US need to not only gain STEM majors but retain them through graduation. Research has shown that the majority of STEM students struggle their first year in college for a variety of reasons. Many academics agree that incoming freshman need to integrate both socially and academically to prevent attrition. This has led to the creation …

Fabrication And Evaluation Of Polyetherimide Membranes Containing Pluronic® P 123 And Graphene For Separation Of Bovine Serum Albumin From Water: A Comparison Between Two Fabrication Methods, Mohammad Hosein Moghadasin

Electronic Theses and Dissertations

Polyetherimide (PEI) ultrafiltration membranes were created and evaluated for their ability to separate bovine serum albumin (BSA) from water using two fabrication methods: nonsolvent induced phase separation (NIPS) and vapor-induced phase separation (VIPS). In the NIPS method, membranes were made with varying amounts of Pluronic® P-123 and with or without graphene nanoplatelets (GNPs). The membrane with 1 wt.% Pluronic® P-123 exhibited the best performance, achieving a pure water flux (PWF) of 355 L m-2 h-1 (LMH) and a rejection rate of 90.9%. Adding 1 wt.% GNPs to this system further improved performance, resulting in a PWF of 747 LMH and …

The Effects Of High School Scheduling Models On Student Achievement In Mississippi, Dustin Ryan Payne

Electronic Theses and Dissertations

This study investigates the effects of different high school scheduling practices on student achievement in Mississippi, considering school economic status as a covariate. Using a robust factorial ANOVA design, the research analyzes reading proficiency, math proficiency, and Mississippi Statewide Accountability System school performance scores across 149 public high schools, excluding those with grades other than 9 through 12, private schools, and charter schools. The primary goal was to determine whether schedule type significantly influences academic performance, independent of economic status. Results indicate that while economic status consistently affects student and school performance, schedule type alone does not show a statistically …

Combatting Suicidality In The Military: Harnessing Forgiveness And Self-Regulation Against The Harrowing Effects Of Moral Injury And Suicidality, Mikaela J. Raley

Electronic Theses and Dissertations

Individuals with military backgrounds are significantly more likely to experience mental health concerns, including suicidal ideation. Moral injury, which is associated with suicidality, is the feeling of shame, grief, and guilt associated with perpetrating, failing to prevent, or witnessing morally transgressive acts. According to the Moral Injury Model, when one acts or witnesses an act that transgresses their moral beliefs, they experience dissonance and internal conflict. A topic that has not yet been studied in terms of moral injury is the positive psychology construct of character strengths, including forgiveness and self-regulation. This study hypothesized ratings of suicide would be positively …

Dunc13 Isoforms, Rim, And Rab3 Differentially Modulate Ethanol Sedation Sensitivity In Drosophila Melanogaster., Gaurav Shrestha

Electronic Theses and Dissertations

Dunc13 is a Drosophila active zone protein homologous to the mammalian Munc13that interacts with RIM and Rab3 as a heterotrimer. Alcohol binds to the C1 domain of Dunc13/Munc13 and inhibits its ability to bind to Diacylglycerol, inhibiting neuronal signaling. The genetic reduction of Dunc13 activity in the Dunc13P84200/+ heterozygotes induces a state in flies that mimics alcohol tolerance, evidenced by increased self-administration, and behavioral, physiological, and molecular resistance. This includes changes in the expression of key synaptic proteins, such as decreased expression of Dunc13 and Syb mRNA, and increased expression of Rim and Rab3 4hrs after ethanol exposure. Dunc13 has …

Linguistic Gender Differences In English Among Saudi Medical Students In Online Courses, Ala Mohammed Alshahrani

Electronic Theses and Dissertations

This qualitative research explores gender differences in language use among Saudi medical students in online courses. Employing purposive sampling, the study, aims to comprehend the influence of gender on language patterns and communication styles in online education. Data collection involves online interviews with five teachers and survey questionnaires administered to twenty actively enrolled Saudi medical students. The interviews provide insights into language use patterns in the online learning environment, while surveys offer a broader perspective on student language use. Thematic analysis unveils recurring themes: “courses developed,” “reasons for online courses,” “interaction among male and female students in online courses,” “comfort …

Elucidating The Mechanisms Of Myosin Ii Force Feedback And Coordination In Actomyosin Ensembles, Omayma Alazzam

Electronic Theses and Dissertations

This dissertation delves into the dynamics of myosin II motors within actomyosin networks, emphasizing their crucial role in muscle functionality and the broader implications for cardiovascular health. Given the critical involvement of myosin II in conditions such as hypertrophic cardiomyopathy (HCM) and heart failure, this research presented here is important for understanding such diseases at the molecular level. Through the use of fluorescence microscopy and optical tweezers, the study reveals novel insights into how myosin II generates force and coordinates within myosin ensembles—a key to grasping the mechanics of muscle contraction. Specifically, this work aimed to unravel the mechanisms of …

Effects Of Music-Induced Arousal On Spatial Cognition, April Marie Joyner

Electronic Theses and Dissertations

Arousal is known to influence the manner in which spatial stimuli are processed and remembered. Although music is considered a spatial stimulus, the relationship between music-induced arousal through music listening and spatial ability remains understudied. This study was designed to determine whether arousal induced by musical stimuli differentially impacts memory performance on a map learning task created to measure spatial memory. Participants were exposed to two different pieces of music selected to induce either high or low arousal or were exposed to a control condition in which music was not presented. Participants listened to music or completed multiplication problems prior …

Effects Of Multiple Stressors On Pseudomonas Fluorescens Over Short And Long Timescales, Parisa Burchfield

Electronic Theses and Dissertations

Stressors are ubiquitous factors in biological systems that result in deviations from an organism's optimal physiological state, potentially causing fitness decreases. Stressors can be biotic (e.g., predators, parasites, competitors) or abiotic (e.g., pH changes, temperature, environmental toxins). Persistent stress can lead to population declines unless organisms respond through mechanisms such as evolutionary adaptation. Experimental evolution with microorganisms, particularly bacteria, is a powerful method for studying these phenomena due to their short generation times, large populations, as well as the ability to control their environment, and freeze and revive populations. Bacteria-phage systems, such as Pseudomonas fluorescens SBW25 and its lytic phage …

Water Insecurity In K-12 Schools In The U.S.: Understanding State Laws, Drinking Water Violations, And Lived Experiences, Shannon O'Donnell Fitzgerald

Electronic Theses and Dissertations

Introduction: Access to safe, reliable drinking water is essential for children's health, development, and academic success. This study examines water insecurity in U.S. K-12 schools, focusing on state policies, county-level violations, associated outcomes, and school staff experiences.

Methods: This mixed-methods study utilized secondary data analysis, mapping, regression analyses, and primary data collection. Secondary data from state sources were used to examine the presence of state legislation and Department of Education and Department of Health policies on school drinking water across the United States, examine associations between state legislation and policies with county drinking water violations, and investigate relationships between water …

Glycopolymeric Nanoparticles Enrich Less Immunogenic Protein Corona And Improve Tumor Delivery Compared To Pegylated Nanoparticles, Kenneth Ryan Hulugalla

Electronic Theses and Dissertations

Nanoparticles (NPs) offer significant promise as drug delivery vehicles; however, their in vivo efficacy is often hindered by the formation of a protein corona (PC), which influences key physiological responses such as blood circulation time, biodistribution, cellular uptake, and intracellular localization. Understanding NP-PC interactions is crucial for optimizing NP design for biomedical applications. Traditional approaches have utilized hydrophilic polymer coatings like polyethylene glycol (PEG) to resist protein adsorption, but glycopolymer-coated nanoparticles have emerged as superior alternatives due to their biocompatibility and ability to reduce the adsorption of highly immunogenic proteins. In this study, we synthesized and characterized glycopolymer-based poly[2(diisopropylamino)ethyl methacrylate-b-poly(methacrylamidoglucopyranose) …

Structural And Binding Studies Of Marine Glycans With Potential Therapeutic Use, Hoda Alsayed Mohamed Ahmed

Electronic Theses and Dissertations

This dissertation presents a comprehensive analysis of various marine-derived polysaccharides, focusing on their structures and binding properties. Using nuclear magnetic resonance (NMR) and surface plasmon resonance (SPR), distinct marine polysaccharides were structurally characterized, and their interactions with various biological targets were evaluated. The initial study explores a glucan isolated from Marcia hiantina, a bivalve mollusk, and its biological activity. Detailed structural analysis via NMR and chromatography techniques revealed a branched glucose-based polysaccharide with potent antioxidant and anti-inflammatory properties. Further studies on the red alga Botryocladia occidentalis identified three sulfated galactans in its cell wall. Through NMR, we characterized the least …

Advancing College Access: A Correlational Inquiry On College Credit Attainment Among Low-Income High School Students, John Dixon

Electronic Theses and Dissertations

A college degree is vital for individuals to access lucrative, fulfilling careers. College access opportunities have existed for decades in K-12 education. In 2024, millions of high school students have access to advanced coursework, exposing them to college-level rigor with the potential to earn college credits (Jagesic et al., 2022). Students from historically marginalized communities do not participate in college courses in high schools at rates similar to White, affluent students. Furthermore, participation in these college opportunities does not always give students college credits. My quantitative, nonexperimental research study aimed to determine the extent of the relationship between the types …

A Longitudinal Study Of Mississippi’S Achievement Scores And School Ratings Based On Principal Preparation, Brittaney Boyd

Electronic Theses and Dissertations

The role of the principal is complex, and there are many ways principals might potentially influence classroom instruction and student learning (Allensworth & Hart, 2018). Over the last decade, the principal’s effectiveness has been evaluated based on student achievement.

The purpose of this quantitative study, A Longitudinal Study of Mississippi’s Achievement Scores and School Ratings Based on Principal Preparation is to determine whether a significant difference exists between Mississippi’s alternate and traditional route principal preparation graduates based on academic successes for the 2017-2018, 2018-2019, 2021-2022, and 2022-2023 school terms, whether a significant difference exists among the different Institutions of Higher …

Applying Dynamics And Geophysical Methods To Hawaiian Volcanic Terrains And Lava Flows, Brody K. Conner

Electronic Theses and Dissertations

Presented here is the culmination of research spurred by a month-long field expedition to the windward side of the Big Island of Hawai’i during July and August 2023. During this expedition, two ground-penetrating radar units, a Mala GX 160 MHz antenna and a Crossover 1760 dual frequency antenna, were used to survey the basaltic, volcanic landscapes of Mauna Loa and Kīlauea. Post-eruptive digital elevation models of the Ahu’ailā’au (2018 Lower Puna) Eruption and Quantum Geographic Information Systems were used in tandem with GPR Insights software to provide a thorough picture of the surface and subsurface lava flows from Ahu’ailā’au. Using …

12.04.2023 Orsp Connect, Liz Williamson

ORED Newsletter

Week of December 4, 2023

Biophysical Study Of The Von Willebrand Factor Via Optical Tweezers—Investigating The Collagen Binding Force Profile To Distinguish Types Of Von Willebrand Disease, Leigh Hardin

Honors Theses

von Willebrand disease (vWD) is a genetic disorder due to quantitative or qualitative abnormalities of the von Willebrand factor (vWF). There are three main types of vWD in addition to acquired von Willebrand syndrome. Type 1 is due to a deficiency of vWF, while Type 3 is due to a complete absence of vWF. Type 2 is due to malformed factors and broken into four subtypes: 2A, 2B, 2M, and 2N. Each subtype corresponds to different abnormalities of the protein that affect its binding to other proteins such as collagen, Factor VIII, platelets, etc. Therefore, determining a patient’s type and …

Researchers Find Turmeric, Thyme Oils Repel Fire Ants, Erin Garrett

University of Mississippi News

OXFORD, Miss. – New findings from the University of Mississippi School of Pharmacy's National Center for Natural Products Research show that two plant oils can effectively repel fire ants.

Associations Between Internalization Of The Model Minority Myth And Burnout Among Asian College Students, Tu Truong

Honors Theses

Background. Burnout has become increasingly prevalent among college students in recent years. A potential risk factor for burnout among Asian and Asian American college students is internalization of the Model Minority Myth, for it may cause psychological distress within Asians. This study has two aims: 1) to examine the association between internalization of the Model Minority Myth (i.e., achievement orientation, unrestricted mobility) and burnout (i.e., exhaustion, cynicism, and efficacy) among Asian college students; and 2) to assess whether the association between internalization of the Model Minority Myth and burnout among Asian college students differs by international student status.

Methods. A …

Laudato Si' And The Christian Ethic, Brandon Kriplean

Venture: The University of Mississippi Undergraduate Research Journal

Christianity, specifically Catholicism, is an inherently anthropocentric religion, with humans having the most dignity of all mortal creatures due to their divine image. However, what does such a lofty view of humanity mean for the current environmental crises? Are Christianity and environmental stewardship mutually exclusive paradigms? Pope Francis has sought to maintain human dignity while at the same time encouraging the Church to recognize that the environment, as God’s creation, is not to be exploited. In other words, an anthropocentric perspective does not equal a disregard for other aspects of creation. His 2015 landmark encyclical, Laudato Si’, sought to highlight …