Digital Commons Network^™

Stimuli-Responsive Glycopolymeric Nanoparticles To Boost Tumor Immunogenicity Through Macrophage-Targeted Therapy, Oluwaseyi Shofolawe-Bakare

Electronic Theses and Dissertations

Tumor-associated macrophages (TAMs) play a substantial role in sculpting the tumor microenvironment (TME) into an immunosuppressive bastion that undermines immune surveillance and enables tumor progression. They therefore represent a promising therapeutic target to make the TME more conducive for anti-tumor immunity and greatly improve treatment outcomes in cancers that are highly resistant to conventional forms of therapy. Several medications have been developed to modulate the activities of TAMs, showing tremendous potential, but these medications lack specificity for TAMs making their use susceptible to adverse side effects that could outweigh prospective benefits. Sophisticated delivery vehicles that can preferentially deliver these medications …

Jtc 24: Discomfort Breeds Growth, Audrey Samples

University of Mississippi News

This story is part of the 2024 Journey to Commencement series, which celebrates the pinnacle of the academic year by highlighting University of Mississippi students and their outstanding academic and personal journeys from college student to college graduate.

Effects Of Vdac 1 And 2 N-Terminal Peptides On Bax Conformation Assessed By Blue Native Gel Electrophoresis, Allison G. Dupree

Honors Theses

Members of the Bcl-2 family are responsible for regulating the intrinsic pathway of apoptosis through Bcl-2 homology 3 (BH3) domain interactions of pro- and anti-apoptotic members. Apoptosis occurs when BH3-only pro-death members overwhelm the pro-survival ones, leading to oligomerization of the multi-BH domain pro-death protein Bax to signal death by releasing cytochrome c from mitochondria into the cytoplasm. This process is essential for proper embryonic tissue development as well as maintenance of mature tissues. While BH3-only proteins such as Bim and Bid bind to and activate Bax through their BH3 domains, other regulators of this mitochondrial permeabilizer may exist. Two …

An Examination Of Cardio-Vascular Patients’ Experiences In A Rural Food Prescription Program, Julia Hansen

Honors Theses

The burden of diet-related chronic diseases in rural communities has prompted the implementation of food prescription programs in rural areas to investigate the impact of more affordable and accessible fresh produce on these vulnerable populations. Because there is little research on the impact of food prescription programs on cardiovascular patients in rural areas, this study will focus on how food prescription programs can benefit this at-risk population. Another goal of this study is to receive feedback from participants to improve food prescription programs to better suit cardiovascular participant needs. To accomplish these goals, a series of questions were asked to …

Cell Cycle Regulator Delays Pilus Production In Caulobacter Crescentus, Eli Johnson

Honors Theses

Caulobacter crescentus is a model bacterium for its unusual life cycle. This cycle features three distinct phases- the stalked stage, pre-divisional or actively dividing stage, and the swarmer stage, characterized by the production of a flagellum and multiple pili. Pili are necessary for cell attachment to surfaces and their reuptake into the cell can help drive the cell cycle forward. The gene that encodes the pilus subunit, pilA, is regulated by four binding sites for the cell cycle regulator CtrA. Previous research has determined that one site induces expression while two of the four sites inhibit expression. It is unknown …

Development Of A Course-Based Undergraduate Research Experience (Cure) Using The Bess Beetle, Sreya Maddali

Honors Theses

Participating in scientific research has increasingly been important in helping students develop necessary science learning skills, like critical thinking. One way of introducing students to these experiences is a Course-based Undergraduate Research Experience (CURE). CUREs enable students to improve in similar ways to internships and are more accessible to students from diverse backgrounds. The goal was to create a CURE centered around ecological genetics, using the Bess Beetle (Odontotaenius disjunctus) as the focal organism of a 16-week course. This species was selected because of its wide geographic range and divergent genetic lineages based on mitochondrial cytochrome oxidase subunit 1 (COI) …

Investigating The Effects Of Suspended Algal Content, Dissolved Oxygen, And Temperature On A High-Frequency Acoustic Attenuation System In A Controlled Laboratory Environment, Noah Watson

Honors Theses

The Single Frequency Acoustic Attenuation System (SFAAS) has been developed at the National Center for Physical Acoustics (NCPA). This system uses acoustic methods to monitor fine suspended sediment concentration in streams. Site-specific calibrations are necessary for this system, and previous research has indicated that algal concentration or dissolved oxygen concentration of water may affect collected data. Temperature, dissolved oxygen concentration, and fluorescence, used as a proxy for algal concentration, were monitored during this system’s use, and calibrations were derived to account for the effect of each of these variables on acoustic measurements. It has been shown that temperature has a …

The Effects Of Additive Manufacturing On Canine Hind Limb Repairment Surgery, Annabel Keers

Honors Theses

The intention of this project is to explore some of the ways that additive manufacturing is affecting veterinary medicine. I will specifically be delving into canine hind limb repairment surgeries, such as cranial cruciate ligament reconstruction. 3D printed prototypes have been utilized in the human medical field for quite a while, and it has inspired such technology to expand into the world of veterinary medicine. Such emerging research is expected to take-off as the pet market grows in size and level of care for the health of our animals.

I took special interest in this field as I will be …

As Bonecas Babadeiras: Drag Subculture And Global Media In Rio De Janeiro, Brazil, Logan Baggett

Honors Theses

21st century global queer culture is seeing a major boom. Drag queens are the most indicative symbols of this boom, traditional practitioners of gender-bending performances that blend music, dance, makeup, and fashion to create breathtaking performances. To this end, this thesis asks the following question: How is local drag performance culture generated in Rio de Janeiro in the context of this 21st century gay boom? In this global metropolis, drag queens confront challenges––racism, classism, sprawling urban geography, and scene competition––that color their interpersonal relationships and financial success. They also find community, creating family units in the absence of heteronormative power …

Can Vice Make Us Virtuous? The Effects Of Greed Reminders On Charitability, Hayley Pitts

Honors Theses

Historically, society wishes to encourage people to be good – but also warns against being bad. There is little comparison between the two of which works: the threat of damnation through vice, or the promise of salvation through virtue. This study examines how each of these affect donation behavior. There are two studies within the present research, each with 149 participants randomly assigned into three categories: control, vice, and virtue. Participants were distracted then asked to view an image based on their randomly assigned category, followed by a donation question: would participants donate a $1.00 bonus to a local charity, …

Get It Out Of My Head: The Psychological Effects Of Music In Strategic Advertising Practices, Brady Jonah Wood

Honors Theses

For generations, music has served as a powerful marketing tool. When radio reigned supreme as the go-to source of household entertainment, savvy advertisers employed any means necessary to capture the listener's attention. Even today, music remains a powerful force in shaping culture, driving, and reinforcing consumer behavior.

This study aims to explore how brands leverage music in their advertisements to enhance consumers' recall of their products. By utilizing music as a marketing tool, advertisers can effectively ingrain their products in consumers' minds. Selected advertisements are examined to determine how the effect of advertising jingles can create a consistent and memorable …

An Analysis Of Professional Education For Future Physicians To Address Implicit Racial Bias In Black Maternal Health, Jasmine Butler

Honors Theses

The history of medicine in the United States is littered with incidences of racism and exploitation of Black Americans. The extensive history of medical racism has continued to be perpetuated in healthcare today. Within the field of maternal health, the dark history of medicine shows its face with the treatment of black mothers. Black maternal health is a current public health crisis currently being exacerbated through discrimination in the form of implicit bias. Implicit bias is a current issue in our healthcare system that needs to be addressed through adequate training of both medical students and physicians. This qualitative research …

Biogeographic Patterns In Phyllosphere Bacterial Communities On Southern Magnolia Trees In A Small Town, Elizabeth M. Eckard, Venkat K. Kota, Kurre T. Luber

Honors Theses

The phyllosphere, consisting of aerial plant surfaces colonized by microorganisms, remains a relatively understudied ecosystem in terms of bacterial biogeography, particularly at intermediate spatial scales. This study characterized the bacterial community on the leaves of 89 Magnolia grandiflora trees throughout a small town, encompassing an area of approximately 60 km². Sequencing of the 16S ribosomal RNA gene revealed the dominant bacterial phyla to be Alphaproteobacteria, Bacteroidetes, and Acidobacteria, consistent with other studies of the phyllosphere. Unlike other studies over smaller spatial scales, there was no significant relationship between phyllosphere community similarity and distance between trees (i.e., trees further …

Morality In Mississippi Science Education: The Impact Of Instruction On Moral Conviction And Emotions Regarding Genetic Engineering, Emily Jenkins

Honors Theses

Moral convictions have been shown to impact learning about science topics, but there exists a gap in literature about whether education on the mechanisms of DNA technologies, such as the recently developed CRISPR-Cas9 system, can affect moral convictions and emotions regarding its use on humans. To investigate this relationship, we examined the results of how three-hundred and fifty-three introductory psychology students at the University of Mississippi rated their moral convictions and emotions on the subject before and after engaging with instructional material. The results indicated that a majority of participants originally had no position (48.2%) or were morally opposed (41.6%). …

Structural And Blood Co-Factor Binding Studies Of A Red Algal Sulfated Galactan, Anderson R. Dewitt

Honors Theses

The red alga Botryocladia occidentalis presents three distinct fractions of sulfated polysaccharides. The elucidation of structures of various B. occidentalis fractions has been explored in prior research. In this study, the first fraction with the least sulfation underwent NMR structure elucidation. Additionally, this sulfated polysaccharide underwent analysis following chemical modifications. Findings have unveiled the presence of both 4-linked α- and 3-linked β-galactose units with the following chemical characteristics: over half of the total galactose units are unsulfated, the α-units are primarily 3,6-anhydrogalactose units either 2-O-methylated or 2-O-sulfated, and the β-galactose units can be 4-O-sulfated or 2,4-O-disulfated. Results from SPR-based assays …

Health, Politics, And Policy: Exploring The Interplay Of Health Status On Voting Behavior And Policy Knowledge Across Political Parties In The United States, Zoey Peters

Honors Theses

ABSTRACT

ZOEY LYNN PETERS: Health, Politics, and Policy: Exploring the Interplay of Health Status on Voting Behavior and Policy Knowledge Across Political Parties in the United States

(Under the direction of Dr. Hannah Allen)

Background. Citizens actively engaging with their politics and government is crucial for the survival of our democracy. Voting and policy knowledge are two significant indicators of citizen engagement and there are many factors that can affect whether people will vote or stay informed on relevant policy. The healthcare system in the United States is a constant topic of controversy in American politics and it impacts every …

Science Quest! An Educational Comic For Fifth Graders In Mississippi, Astra Hahm

Honors Theses

Astra Hahm: Science Quest! An educational comic for fifth graders in Mississippi (Under the direction of Dr. Joshua Eyler)

Science Quest! is an educational comic aimed at fifth graders in Mississippi to teach them science in a way that differs from how they learn science in class. The inspirations for the creation of Science Quest! are both my interests as a child and my vision of the future as an adult. During Sophomore year, I had the privilege of volunteering at Oxford Intermediate School, where I witnessed students play a variety of educational games, which reminded me of my childhood. …

Bioinformatic Comparison And Salinity Tolerance Of Various Cyanobacterial Strains, Lucie Rowe

Honors Theses

Cyanobacteria are an abundant and diverse group of photosynthetic prokaryotes with a long evolutionary history, which presents challenges for comprehensive taxonomic classification. Phylogenies were traditionally constructed based on the highly conserved 16S rRNA gene, but research has increasingly relied upon whole genome sequencing to elucidate evolutionary relationships, despite increased cost and time. In this thesis, publicly available genome sequences of various cyanobacterial strains were utilized to determine if the whole rRNA region, which includes the 16S, 23S, and 5S genes as well as the spacer regions between, could provide accurate, yet cost/time efficient representations of their evolutionary relationships. From phylogenetic …

Jtc 24: A World Away, Pam Starling

University of Mississippi News

This story is part of the 2024 Journey to Commencement series, which celebrates the pinnacle of the academic year by highlighting University of Mississippi students and their outstanding academic and personal journeys from college student to college graduate.

Fe(Iii) And Mn(Ii) Binding De Novo Designed Peptides And Their Oxidation With H2o2, Hannah Randall, Russ Upton

Honors Theses

Metalloenzymes perform a wide variety of reactions that are instrumental to the basic functions of life. Learning more about those enzymes–their structure, folding, active sites, and co-factors–can help to not only better understand the finer details of the chemical world, but also help provide answers and possible solutions to questions pertaining to alternative energy. Particulate Methane Monooxygenase (pMMO) is a metalloenzyme that oxidizes methane into methanol in the biological processes of some methanogenic bacteria, a valuable part of their process to obtain energy. One of its active sites, CuB, has a relatively unknown function. Heptad repeats of model enzymes have …

Guardian's Goals And Gains: The Relationship Between Need Satisfaction And Parenting Goals In Parents Of Toddlers, Kallen E. Mitchell

Honors Theses

Self Determination Theory (SDT) theorizes that when three core psychological needs are met (i.e., competence, relatedness, and autonomy) then humans reach their highest level of optimization (Deci & Ryan, 2000). One common way people tend to satisfy these needs is through social relationships, typically ones where their efforts can be reciprocated; however, not all relationships are reciprocal. This study looks at the psychological needs within an asymmetrical relationship between a parent and their toddler aged child. Given an already established relationship (Smith et al. 2023) between need satisfaction and the types of goals parents have for their college aged kids …

Role Of Dunc-13 Isoforms In Alcohol Sensitivity In Drosophila, Makenzie Havard

Honors Theses

Functional alcohol tolerance is an adaptation made by the nervous system to high doses of alcohol, and is seen by a significant reduction in sensitivity to this drug. This tolerance is a significant contributing factor in the progression to Alcohol Use Disorders. A major goal of alcohol research is to understand how alcohol induces this tolerance. Dunc13 is a presynaptic active zone protein essential in synaptic vesicle docking and priming. Alcohol binds to the C1 domain of Dunc13 at physiological concentrations, which inhibits Dunc13 from binding Diacylglycerol. This inhibition is predicted to reduce Dunc13 activity and presynaptic activity. Yet, genetically …

Functional Connectivity Of The Hippocampus In Autism Spectrum Disorder, Noah Watts

Honors Theses

Autism spectrum disorder (ASD) is a neurological developmental disorder that affects around 1/44 of individuals in the United States. ASD individuals tend to struggle with things such as communication and socialization. This disorder has been found to affect many brain regions; however, autism’s effect on the hippocampus has been heavily understudied. Since the hippocampus is not commonly referred to as the brain region affected by autism, the importance of the hippocampus in ASD may have been unrecognized. While ASD hippocampi have been very narrowly researched (only size and shape), there is compelling evidence that the hippocampus could be another part …

Spin Coating Multilayer Polymer Films To Improve The Consistency And Longevity Of Interval Drug Release, Katherine Nevils

Honors Theses

Treatment-resistant depression (TRD) is a clinical diagnosis for patients suffering from major depressive disorder (MDD). An inadequate response to the dosage or duration of antidepressant medication can lead to the diagnosis of TRD. This diagnosis is common in up to 50% of patients with MDD following treatment. Microdosing of classical psychedelics such as lysergic acid diethylamide (LSD) has been shown to have positive cognitive and therapeutic effects on patients with TRD. However, issues of patient compliance to the complex regimen and abuse/diversion of the schedule I controlled substances remain unresolved. The goal of this project is to create an implantable, …

Into The Wild: A Journey Paddling The Lower Mississippi River With Quapaw Canoe Company, Sarah Caroline Crall

Honors Theses

Humanity’s profound relationship with water is undeniable. From our reliance on it for sustenance and transportation to the recreation it provides, water is a fundamental aspect of our existence. Yet, in our contemporary era, we find ourselves increasingly disconnected from this life-giving source that shapes us and our surroundings. The Mississippi River stands as a prime example of this detachment. Often overlooked as a lifeless river, nothing more than the backdrop to our daily lives, its significance as the heart of America is underappreciated and misunderstood by many. This thesis embarks on a journey to share the true reality that …

La Langue Des Autres: The Linguistic Evolution Of African Representation In French Popular Culture, Colonialism To Present, Kathrynanne Eastman

Honors Theses

This thesis examines the linguistic representation of African peoples and cultures in French popular culture, specifically as this pertains to immigration. The foundational research question of this project is: how has the representation of Africans in French popular culture evolved since the colonial period? In order to answer this question, I examine seven sources of popular culture, all works of either literature or cinema, depicting three different time periods: 19th-century French colonization in Algeria (1830-1900), the post-World War II “Trente Glorieuses” [Thirty Glorious Years] (1945 to 1975), and the contemporary era (1990-present). I lay out and analyze the language present …

Validation Of A Triple Quadrupole Lcms Instrument For Cocaine And Amphetamines, Isabel R. Nichols

Honors Theses

Despite the opioid crisis taking headlines, the abuse of cocaine and amphetamines remains rampant and laboratory instruments must be able to effectively and reliably handle the overwhelming case load. In this study, an Agilent 6475 Triple Quadrupole (QQQ) LCMS, recently acquired by the Tarrant County Medical Examiner’s Office (TCMEO) in Fort Worth, Texas, was validated for identifying and quantifying CocAmps. Results show that the instrument was fit-for-purpose and that the instrument passed all validation tests. Reproducibility was ≤ 20% RSD for 12 QC replicates, 6 of blood and 6 of urine. Accuracy was ± 20%. A 98.9% recovery was yielded …

Jtc 24: Adapting And Excelling, Erin Garrett

University of Mississippi News

This story is part of the 2024 Journey to Commencement series, which celebrates the pinnacle of the academic year by highlighting University of Mississippi students and their outstanding academic and personal journeys from college student to college graduate.

Creating A Collapsible Sling Lift Capable Of Transporting Patients Between Various Locations, Cameron Delaney Hillman, Macey Jewell Ross, Lydia Noel Miller

Honors Theses

As Senior Biomedical Engineering students at the University of Mississippi, we, Lainey Hillman, Lydia Miller, and Macey Ross, are required to complete a final senior capstone for our department. This project aims to provide a solution to a current unmet clinical need in the healthcare industry, thus our team sought to improve the lack of transportability of sling lifts. The current sling lifts on the market display numerous issues: heavy, bulky, use confined to certain areas, and use specific for only one type of transportation. To combat these problems, we designed a sling lift that was lightweight, collapsible, safe, and …

The Effects Of Vigorous-Intensity Acute Exercise On Hippocampal- And Prefrontal Cortex-Dependent Memory, Lauren Hord

Honors Theses

Acute exercise has been shown to differentially impact memory, dependent on whether the task is considered prefrontal cortex- or hippocampal-dependent. More specifically, acute exercise has been shown to impair PFC-dependent memory while enhancing hippocampal-dependent memory. No study has compared whether exercise differentially impacts separate types of cognition, so this experiment was designed to determine the relationship between high-intensity acute exercise and both prefrontal cortex-dependent and hippocampal-dependent memory. This study consisted of five total visits for 55 participants. In the first visit, participants engaged in a maximal exercise test, where their heart rate reserve was obtained. In visits 2-5, participants engaged …