Digital Commons Network^™

Ciprofloxacin Loaded Nanostructured Lipid Carriers Incorporated Into In-Situ Gels To Improve Management Of Bacterial Endophthalmitis, Ahmed Youssef, Narendar Dudhipala, Soumyajit Majumdar

Faculty and Student Publications

© 2020 by the authors. Bacterial endophthalmitis (BE) is a potentially sight-threatening inflammatory reaction of the intraocular fluids or tissues caused by bacteria. Ciprofloxacin (CIP) eye drops are prescribed as first-line therapy in BE. However, frequent administration is necessary due to precorneal loss and poor ocular bioavailability. The objective of the current research was to prepare CIP containing nanostructured lipid carriers (CIP-NLCs) loaded an in situ gel system (CIP-NLC-IG) for topical ocular administration for enhanced and sustained antibacterial activity in BE treatment. CIP-NLCs were prepared by the hot homogenization method and optimized based on physicochemical characteristics and physical stability. The …

Combining Like Terms: A Qualitative Meta-Synthesis Of Algebra I Interventions In Mathematics And Special Education, Rebecca A. Dibbs, Brittany L. Hott, Amelia Martin, Leslie Raymond, Taylor Kline

Faculty and Student Publications

© 2020 International Journal of Education in Mathematics, Science and Technology. All rights reserved. Many students struggle with the transition from arithmetic to algebra. Despite meta-analytic work on algebra instruction and calls for meta-syntheses of mathematics education topics, little has been done to synthesize the corpus of qualitative mathematics education research in algebra. The purpose of this meta-synthesis is to summarize the techniques teachers use to elicit algebraic thinking from students with mathematics difficulty or disability in the mathematics and special education literature. Although both mathematics and special educators used student-centered and collaborative techniques to encourage students to share algebraic …

Estimation Of Dynamic Bivariate Correlation Using A Weighted Graph Algorithm, Majnu John, Yihren Wu, Manjari Narayan, Aparna John, Toshikazu Ikuta, Janina Ferbinteanu

Faculty and Student Publications

© 2020 by the authors. Dynamic correlation is the correlation between two time series across time. Two approaches that currently exist in neuroscience literature for dynamic correlation estimation are the sliding window method and dynamic conditional correlation. In this paper, we first show the limitations of these two methods especially in the presence of extreme values. We present an alternate approach for dynamic correlation estimation based on a weighted graph and show using simulations and real data analyses the advantages of the new approach over the existing ones. We also provide some theoretical justifications and present a framework for quantifying …

On The Aα-Spectral Radii Of Cactus Graphs, Chunxiang Wang, Shaohui Wang, Jia Bao Liu, Bing Wei

Faculty and Student Publications

© 2020 by the authors. Let A(G) be the adjacent matrix and D(G) the diagonal matrix of the degrees of a graph G, respectively. For 0 ≤ α ≤ 1, the Aα-matrix is the general adjacency and signless Laplacian spectral matrix having the form of Aα(G) = αD(G) + (1-α)A(G). Clearly, A0(G) is the adjacent matrix and 2A1/2 is the signless Laplacian matrix. A cactus is a connected graph such that any two of its cycles have at most one common vertex, that is an extension of the tree. The Aα-spectral radius of a cactus graph with n vertices and …

Pyridyl Co2Fixation Enabled By A Secondary Hydrogen Bonding Coordination Sphere, Jacqueline N. Gayton, Qing Li, Lakeeta Sanders, Roberta R. Rodrigues, Glake Hill, Jared H. Delcamp

Faculty and Student Publications

Copyright © 2020 American Chemical Society. Reversible CO2 binders under ambient conditions are of significant interest for multiple applications in sensing and capture technologies. In this paper, a general systematic way to evaluate CO2 receptors with π-systems is put forward. A series of receptors (five pyridine-based and one triazine-based) are evaluated as CO2 binders in terms of number of hydrogen bonding sites, strength of hydrogen bond donors, and number of nucleophilic sites. The binding of CO2 to the receptors was probed by computational models, absorption spectroscopy, fluorescence spectroscopy, cyclic voltammetry, and 1H NMR studies. Multiple solvents with varying ionic strength …

Mississippi Teacher Corps Offers Free Summer School Across State, Andrew M. Abernathy

University of Mississippi News

In response to social distancing, longtime teacher program takes programming online

Issue 348: May 2020, The Local Voice

The Local Voice

No abstract provided.

An Investigation Of The Experiences Of New Teachers And Their Reasons To Stay In The Classroom, Jessa N. Mcentire

Honors Theses

New teacher attrition rates have increased over the years. Twenty percent of new teachers will leave the profession after three years. That number increases to forty-four percent after five years of teaching. For those just entering the profession, these numbers can be daunting. The purpose of this study was to determine the reasons for this departure and what actions schools employ to help lessen this attrition rate. After screening four teachers to gain a general insight into their experiences, eight teachers with a similar educational background were selected for additional interviews. This study was intended to determine how much of …

Synthesis Of Fluorinated Pyrazoles Via Intra- And Intermolecular Cyclization Reactions, Matthew Saucier

Honors Theses

Pyrazole-based pharmaceuticals treat a wide array of diseases and conditions including obesity, diabetes, cancer, microbial and viral infections, pain and inflammation, and many neurological disorders. Syntheses for this biologically significant substrate have been well developed, but current methods to afford fluorinated pyrazoles are limited by variability and selectivity. By 2013, over 25% of all drugs available on the market contained the element fluorine due to its unique characteristics leading to improved target protein binding, bioavailability, and metabolic stability. In order to harness these pharmaceutical benefits of fluorine and overcome its difficulty in handling and stability, we set out to develop …

Approaches Towards The Synthesis Of Ketamine Metabolites, Ann K. Patrick

Honors Theses

Major Depressive disorder (MDD) plagues society and stands at the forefront of research as MDD affects approximately 16% of the population. Pharmaceutical drugs, including the selective serotonin reuptake inhibitors (SSRIs), have been used for MDD treatment and remain a popular option today. However, current antidepressant treatments have proven to be ineffective in just less than half of the patients. Research continues with the goal to better understand the mechanisms of the pathology of depression and to search for other treatment options. For example, the stress-neurogenesis hypothesis investigates the role of stress and decreased neuroplasticity within MDD.

Supporting the stress-neurogenesis hypothesis, …

13c Nmr Substituent Effects On Para-Substituted Tolans: Using Deuteration To Assign 13c Signals In Methyltolan, Reece Crumpler

Honors Theses

Substituents are capable of affecting their molecules via induction, resonance, and field effects. Using the Hammett equation, the effect a range of substituents has on different properties of a molecule can be quantified.¹ Hammett’s parameters have been correlated with the substituent effects on ¹H NMR chemical shifts in different molecules, including experiments on substituted chalcones (1,3-diarylpropenones).² The effect a substituent has on a molecule can also be observed using ¹³C NMR. The chemical shifts of carbons throughout the molecule may be affected by the substituent. This was shown to be true by Wilson and Zehr in …

Synthesis Of Polyethylene Glycol - Trifluoromethyl Sulfonamide And Analysis Of Its Ion-Transport Properties, Andrew Groneck

Honors Theses

This project investigates the synthetic pathway to develop a polyethylene glycol – trifluoromethyl sulfonamide compound to be used as an electrolyte in a proton exchange membrane fuel cell. The inspiration to develop a trifluoromethyl sulfonamide compound tethered to a polyethylene glycol polymer was inspired by the work of David P. Siska and D. F. Shriver in their studies of polysiloxane – trifluoromethyl sulfonamide electrolytes.

In this thesis, I have developed the synthesis of MePEG7-Trifluoromethyl sulfonamide (MePEG7-NHSO2CF3) from monomethylpolyethylene glycol (MePEG7OH). Unfortunately, due to the COVID-19 pandemic, I was unable to complete the depronation and ion-exchange to the Li+ and H+ …

Heel Down And Toe-Off Time Measured With Ultrasonic Doppler System And Force Plate Sensor, Sabin Timsina

Honors Theses

Collie Box is a medical device that measures the gait parameters of the person walk- ing in front of it. This device uses the Ultrasonic Doppler system to extract the heel-contact and toe-off times of a person walking within the range of 2-10 meters. These times are used to determine the leg’s swing phase and double stance times. The ultrasonic transducer of 10mm diameter is driven at 40kHz. At the time of the heel-contact and toe-off, foot velocity is zero while the torso part of the human body is still in motion. The wide directivity of 10mm diameter ultrasonic transducer …

Investigation Of The History Of Fingerprinting, Advancements In The Field, And Development Of Potential Methods That Could Improve The Detection Of Endogenous And Exogenous Drugs In Latent Prints, Kristen Malloy

Honors Theses

When someone thinks of fingerprinting, they are most likely going to picture how a latent print is matched to the fingerprint of a suspect based on ridge pattern analysis. However, there is much more information that can be obtained from a latent print. The work performed in this thesis focuses the detection of exogenous and endogenous drugs in latent prints. The experiments performed analyzed fingerprints from volunteers that were contaminated with one of three common painkillers: acetaminophen, acetylsalicylic acid (ASA), and ibuprofen. Three different instruments were tested for this purpose: MALDI-MS, ATR-FTIR, and LC-MS. Based on the results gathered, it …

Teacher Evaluation Of An Integrated Nutrition Curriculum For Mississippi Schools, Janiya A. Davis

Honors Theses

The prevalence of childhood obesity in the United States has more than tripled over the last four decades from 5 percent in 1978 to 18.5 percent in 2016, and according to the Mississippi Obesity Action Plan, 40.4% of Mississippi elementary school children (grades K-5) were either overweight or obese. Some reports have suggested that Mississippi’s overall obesity rate could reach 66.7% by 2030. Although the literature on best practices for the prevention of this condition is limited, some success has been achieved through the use of school-based nutrition interventions, in which children are taught how to make healthy food choices. …

The Embark® Protocol: Dog Genomics In Genetics Laboratories, Alexandra Kissel

Honors Theses

In a world of ever-advancing technology, it is imperative that young pre-health professionals are educated according to the most relevant research. One of the most fundamental, foundational concepts of health is genetics. This field is rapidly expanding, and quickly engraining itself into the realm of healthcare. Genetic testing and gene therapies, once subjects of science fiction, have become commonplace. It is more important than ever that health professionals have a concrete knowledge of genetics, and this begins with the proper education of pre-health students.

With this idea in mind, a laboratory protocol was designed for students of the Bisc 336 …

Silver-Catalyzed Synthesis Of Disubstituted Fluorinated Isoxazoles, Micah Stewart

Honors Theses

The presence of fluorine can provide organic compounds with useful biological properties, such as increased metabolic stability and drug uptake. Because of these advantages, fluorinated compounds make up about 30% of the drug industry. However, fluorination of complex molecules is difficult due to fluorine’s high electronegativity.

Fluorinated isoxazoles are of particular interest in the pharmaceutical industry. Isoxazoles are five-membered heterocycles with oxygen and nitrogen in the 1, 2 positions that are able to engage in interactions unavailable to other ring structures, conferring advantageous biological properties upon compounds containing them. However, there are limited synthetic routes for fluorinated isoxazoles, and those …

Intrinsic Buffer Hydroxyl Radical Dosimetry For Hydroxyl Radical Protein Footprinting, Addison Roush

Honors Theses

Hydroxyl radical protein footprinting (HRPF) coupled to mass spectrometry is a powerful technique for the analysis of protein topography as it generates covalent mass labels that can survive downstream sample handling, and it is sensitive to the solvent accessibility of amino acid sidechains. Of the multiple platforms for HRPF, fast photochemical oxidation of proteins (FPOP) utilizes a pulsed 248 nm KrF excimer laser to label proteins by photolyzing hydrogen peroxide. FPOP is the most widely used HRPF platform because it labels proteins faster than unfolding can occur. Variations in FPOP sample conditions make it difficult to compare results between experiments …

Integrating Google Forms As A Means Of Formative Assessment In The Elementary Math Classroom, Morgan Douell

Honors Theses

This study provides a case study in the use of Google Forms as a formative assessment tool. Literature regarding formative assessment is included and models are applied in lesson plan development and implementation. However, no research has been found linking the implementation of formative assessment along with Google Forms. Formative assessment and Google Forms both provide feedback to learners, which is a critical component of formative assessment. This study reported the use of formative assessment in conjunction with Google Forms and the impact it has on the lesson planning process. The researcher designed a lesson plan using the principles of …

Investigatin Actin-Myosin Mechanics To Model Heart Disease Using Fluorescence Microscopy And Optical Trapping, Justin Edward Reynolds

Honors Theses

Hypertrophic cardiomyopathy (HCM) is a hereditary disease in which the myocardium becomes hypertrophied, making it more difficult for the heart to pump blood. HCM is commonly caused by a mutation in the β-cardiac myosin II heavy chain. Myosin is a motor protein that facilitates muscle contraction by converting chemical energy from ATP hydrolysis into mechanical work and concomitantly moving along actin filaments. Optical tweezers have been used previously to analyze single myosin biophysical properties; however, myosin does not work as a single unit within the heart. Multiple myosin interacts to displace actin filaments and do not have the same properties …

Electronic Health Records And Health Information Exchange And Their Impact On International Healthcare System Efficiency, David Pfaehler

Honors Theses

The 19th century epidemiological transition in healthcare caused a major shift in physician focus from curing one-time, deadly illness to managing chronic disease. Now, even the most advanced international healthcare systems must find a way to increase their efficiency in order to compensate for heightened strains on medical systems and swelling costs of healthcare delivery. Fortunately, recent technological innovation and, chiefly, the growth of Electronic Health Records (EHRs) provide a potential solution to this looming threat. EHRs are digital charts with the potential to store and share patient health data among providers to offer the most informed, streamlined care available. …

Positive Behavior Interventions And Supports, Meredith George

Honors Theses

The purpose of this thesis is to examine the history, characteristics, and efficacy of Positive Behavior Interventions and Supports (PBIS) as a substitution for traditional exclusionary discipline practices in response to negative and disruptive behavior in schools. Disruptive behavior is a significant concern for classroom teachers; effective solutions for minimizing disruptions are necessary to curb teacher burnout and improve attrition rates. PBIS relates to an implementation framework as opposed to a singular behavior program, therefore schools have a multitude of intervention options when adopting a PBIS approach to behavior. Three PBIS strategies (restorative circles, token economy, self-monitoring of performance) are …

Case Studies On Special Topics In Accounting, Anna Stephens

Honors Theses

This thesis is a collection of twelve different case studies that investigate various accounting concepts and financial issues. During the fall of 2019 and the spring of 2020, I compiled my thesis under the direction and guidance of Dr. Dickinson. The cases cover a variety of topics that include personal opinions on world-wide financial topics, interviews of current professionals in the field, and analyses of different scenarios. Each case study is independent of one another, but together they demonstrate a comprehensive understanding of the accounting curriculum. These cases further developed my technical skills and enhanced my understanding of accounting concepts …

A Raman Spectroscopic And Quantum Chemical Investigation Of Serotonin, It's Intramolecular Interactions, And The Solvent Effects Of Methanol, Ethanol, And Water, Mallory Loe

Honors Theses

Serotonin, or 5-hydroxytryptamine, is a neurotransmitter and metabolite vital to the normal function of the cardiovascular, gastrointestinal, and nervous systems. Although it might be colloquially known as the ‘happiness drug,’ malfunctions in serotoninergic pathways can result in mental health disorders, heart disease, irritable bowel syndrome, and even collateral death. Without a current method to directly measure, or even detect, serotonin in the human body, these diseases, along with many others, pose a threat of developing without proper warning. Raman spectroscopy presents a unique method to vibrationally characterize molecules based upon the inelastic scattering of light. Serotonin’s unique, amphipathic structure presents …

Comparative Analysis Of Simulation Models Of The Production Of Ethylbenzene, Osariemen Imafidon

Honors Theses

Process Engineering is all about making sure a raw material can become the desired product with as little variation as possible, while achieving the customer's specifications. Many equipment used for chemical processes cannot be physically inspected during operation at steady state, hence, the need for simulation software. The objective of this study was to compare the results of three different simulation packages to evaluate their efficacy within process design.

This study focused on the economic analysis of the production of Ethylbenzene using various models. The base case variables were inputted into each model to simulate the calculations for a fully …

A Comprehensive Study Of Accounting Principles And Applications Through Analysis Of Case Studies, Guy Freeman

Honors Theses

The following thesis is a compilation of case studies that provide a detailed analysis of various financial accounting standards in agreement with Generally Accepted Accounting Principles as governed by the Financial Accounting Standards Board. In concurrence with the topics learned in the Patterson School of Accountancy program, each case focuses on a separate subject of financial reporting through application within specific corporations and dissertations. This thesis explores understanding of accounting principles, financial statement preparation and analysis, current accounting topics, and real-life application for a career in public accounting. Additionally, the thesis work incorporated knowledge from studies in other coursework, such …

Case Analyses In Financial Accounting, Jordan Watts

Honors Theses

The following thesis explores topics in the profession of public accounting, a diverse and ever-evolving field. As the global business environment and economy develop, so must accounting standards and ideas in order to protect the interests of the masses who invest and take part in the larger economy. The following cases expound on important concepts in the field of accountancy and provide careful consideration of standards utilized and debated worldwide. Each case is explored within the context of a different company or situation, allowing for a diverse palette of research topics from which to view the business world through an …

Isolation, Identification, And Investigation Of A Novel Bioactive Furanocoumarin From Leaves Of Amyris Elemifera, Amy K. Bracken

Honors Theses

Plants produce biologically active compounds that humans have utilized for many agricultural applications. Amyris elemifera was investigated due to the known bioactivity of its family, Rutaceae, and its use in medicines in tribes of the Bahamas. Biotage® and TLC guided fractionation of the EtOAc, hexane, and MeOH extracts of the leaves of Amyris elemifera yielded bioactive compounds. Most significantly, a novel furanocoumarin, 8-(3-methylbut-2-enyloxy)-marmesin acetate (1), and its analog 8-(3-methylbut-2-enyloxy)-marmesin (2), were isolated. The structures were identified via NMR and X-ray crystallography techniques; the X-ray crystal structure for 1 was reported for the first time, and the …

Critical Thinking In Curriculum: Designing An Instrument To Measure Identified Features, Claire Gershon

Honors Theses

Critical thinking is an increasingly important skill in our society and should be cultivated through education. Therefore, the curricula used in our schools should support students in developing critical thinking skills. This study aims to understand what aspects of curricula promote critical thinking, how to measure it, and whether or not current curricula meet these standards. After reviewing the literature, elements of curricula were identified as beneficial in promoting critical thinking. In teacher curricula materials, these are educative features such as identifying misconceptions, explanations of how to use formative assessment, and explanations of pedagogy. In student curricula materials, these educative …

Liberté, Égalité, Manifester: Explaining The Yellow Vest Movement In France, Brady L. Cole

Honors Theses

Les Gilets Jaunes, or the yellow vests, is a movement of protestors that have had a large presence in France since 2018. Beginning as an online petition against French President Emmanuel Macron’s fuel tax hike, the movement has quickly amassed several hundred thousand protestors in Paris and other cities across the country. It is the objective of this thesis to examine potential reasons why 300,000 people have felt the need to protest throughout France, apart from the now rescinded fuel tax.

To this end, a sample of data from the Varieties of Democracy database was selected. These variables covered various …