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Development And Characterization Of Sustained-Released Donepezil Hydrochloride Solid Dispersions Using Hot Melt Extrusion Technology, Abdullah Alshetaili, Bjad K. Almutairy, Sultan M. Alshehri, Michael A. Repka Feb 2021

Development And Characterization Of Sustained-Released Donepezil Hydrochloride Solid Dispersions Using Hot Melt Extrusion Technology, Abdullah Alshetaili, Bjad K. Almutairy, Sultan M. Alshehri, Michael A. Repka

Faculty and Student Publications

The aim of this work was to develop the sustained release formulation of donepezil hydrochloride (DH) using the hot-melt extruded solid dispersion technique via the rational screening of hydrophobic carriers. Hydrophobic carriers with different physicochemical properties such as pH-independent swellability, low-permeability (Eudragit® RS PO (E-RS)), pH-independent non-swellability (ethyl cellulose N7 (EC-N7)), and the presence of lipids (Compritol® 888 ATO (C-888)) with or without pore-forming agents were used to achieve the sustained release profile of DH. Mannitol (MNT) was chosen as the temporary pore-forming agent. The thermal analysis showed that both the drug and C-888 preserved their crystallinity within a solid …


Effective Inhibition Of Sars-Cov-2 Entry By Heparin And Enoxaparin Derivatives, Ritesh Tandon, Joshua S. Sharp, Fuming Zhang, Vitor H. Pomin, Nicole M. Ashpole, Dipanwita Mitra, Martin G. Mccandless, Weihua Jin, Hao Liu, Poonam Sharma, Robert J. Linhardt Feb 2021

Effective Inhibition Of Sars-Cov-2 Entry By Heparin And Enoxaparin Derivatives, Ritesh Tandon, Joshua S. Sharp, Fuming Zhang, Vitor H. Pomin, Nicole M. Ashpole, Dipanwita Mitra, Martin G. Mccandless, Weihua Jin, Hao Liu, Poonam Sharma, Robert J. Linhardt

Faculty and Student Publications

Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has caused a pandemic of historic proportions and continues to spread globally, with enormous consequences to human health. Currently there is no vaccine, effective therapeutic, or prophylactic. As with other betacoronaviruses, attachment and entry of SARS-CoV-2 are mediated by the spike glycoprotein (SGP). In addition to its well-documented interaction with its receptor, human angiotensin-converting enzyme 2 (hACE2), SGP has been found to bind to glycosaminoglycans like heparan sulfate, which is found on the surface of virtually all mammalian cells. Here, we pseudotyped SARS-CoV-2 SGP on a third-generation lentiviral (pLV) vector and tested the …


Gut Microbiomes Of Freshwater Mussels (Unionidae) Are Taxonomically And Phylogenetically Variable Across Years But Remain Functionally Stable, Mark Mccauley, Marlène Chiarello, Carla L. Atkinson, Colin R. Jackson Feb 2021

Gut Microbiomes Of Freshwater Mussels (Unionidae) Are Taxonomically And Phylogenetically Variable Across Years But Remain Functionally Stable, Mark Mccauley, Marlène Chiarello, Carla L. Atkinson, Colin R. Jackson

Faculty and Student Publications

Freshwater mussels perform essential ecosystem functions, yet we have no information on how their microbiomes fluctuate over time. In this study, we examined temporal variation in the microbiome of six mussel species (Lampsilis ornata, Obovaria unicolor, Elliptio arca, Fusconaia cerina, Cyclonaias asperata, and Tritogonia verrucosa) sampled from the same river in 2016 and 2019. We examined the taxonomic, phylogenetic, and inferred functional (from 16S rRNA sequences) facets of their microbiome diversity. Significant differences between the two years were identified in five of the six species sampled. However, not all species that exhibited a temporally variable microbiome were functionally distinct across …


Pharmacy Matters - February 2021, University Of Mississippi. School Of Pharmacy Feb 2021

Pharmacy Matters - February 2021, University Of Mississippi. School Of Pharmacy

Pharmacy Matters Newsletters

Featured stories: "Pharmacy School Forms Diversity and Inclusion Committee," "Pediatric CBD Drug Trial at UMMC Gets Two-Year Extension," "Dean David D. Allen Rings in a New Semester," "Task Force Preparing for Campuswide COVID-19 Vaccinations"


Researchers Cited In National Racial Progress Study, J. B. Clark Feb 2021

Researchers Cited In National Racial Progress Study, J. B. Clark

University of Mississippi News

Community-driven research project ranks Mississippi in Top 5 for progress toward closing gaps


Revenue Recognition, February 1, 2021; Audit And Accounting Guide, American Institute Of Certified Public Accountants (Aicpa) Feb 2021

Revenue Recognition, February 1, 2021; Audit And Accounting Guide, American Institute Of Certified Public Accountants (Aicpa)

Industry Guides (AAGs), Risk Alerts, and Checklists

No abstract provided.


Pharmacy Professor Receives Um Faculty Achievement Award, Whitney Tarpy Jan 2021

Pharmacy Professor Receives Um Faculty Achievement Award, Whitney Tarpy

University of Mississippi News

David Colby honored for success in teaching, research and mentoring


A Deeper Dive Into Vaccines, Jean Gispen Jan 2021

A Deeper Dive Into Vaccines, Jean Gispen

University of Mississippi News

No abstract provided.


January 28, 2021, The Daily Mississippian Jan 2021

January 28, 2021, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.


Issue 364: January 28-February 11, 2021, The Local Voice Jan 2021

Issue 364: January 28-February 11, 2021, The Local Voice

The Local Voice

No abstract provided.


Delta Directions Consortium (Ddc): Summary Of Collaborative Pathways, Emily Broad Leib, Emma I. Scott, John J. Green Jan 2021

Delta Directions Consortium (Ddc): Summary Of Collaborative Pathways, Emily Broad Leib, Emma I. Scott, John J. Green

Delta Directions: Publications

The Delta Directions Consortium is an interdisciplinary network of individuals, academic institutions, non-profit organizations, and foundations that work together to create positive social change in the multi-state Mississippi Delta Region. Goals include improving public health and promoting socioeconomic development. The Consortium is not an independent non-profit organization but, rather, an alliance of partners committed to collaborative and innovative problem-solving. This document provides a summary of pathways for partners in the Delta Directions Consortium, with emphasis on substantive topics and projects. It should be read as a living document to frame ideas and approaches that will be adapted in response to …


Daily Digest - Wednesday, January 27, 2021 Covid-19 Updates, University Of Mississippi Jan 2021

Daily Digest - Wednesday, January 27, 2021 Covid-19 Updates, University Of Mississippi

COVID-19 Website Archives

Campus Update Daily Digest for Wednesday, January 27, 2021


Um Shares Update On Commencement Ceremonies For Classes Of 2020, 2021, Staff Report Jan 2021

Um Shares Update On Commencement Ceremonies For Classes Of 2020, 2021, Staff Report

University of Mississippi News

Convocations set for Vaught-Hemingway Stadium to allow for social distancing


Health And Kinesiology Doctoral Program Soars To Elite Ranking, Sarah Sapp Jan 2021

Health And Kinesiology Doctoral Program Soars To Elite Ranking, Sarah Sapp

University of Mississippi News

Ph.D. program recognized among Top 10 by National Academy of Kinesiology


University Partners With Msu To Advance Pharmacy Education, Whitney Tarpy Jan 2021

University Partners With Msu To Advance Pharmacy Education, Whitney Tarpy

University of Mississippi News

Preferred admission program offers students spot in Ole Miss professional program


Professor Elected To Lead National Rural Sociology Association, Staff Report Jan 2021

Professor Elected To Lead National Rural Sociology Association, Staff Report

University of Mississippi News

Vaunted researcher will put stamp on national organization


Um Announces New Towns For M Partner Community Improvement Program, Edwin B. Smith Jan 2021

Um Announces New Towns For M Partner Community Improvement Program, Edwin B. Smith

University of Mississippi News

McLean Institute adds Ecru, Pontotoc for Phase 2 of community building


Task Force Preparing For Campuswide Covid-19 Vaccinations, Edwin B. Smith Jan 2021

Task Force Preparing For Campuswide Covid-19 Vaccinations, Edwin B. Smith

University of Mississippi News

Location, schedule set for UM immunizations once vaccine arrives


Daily Digest - Wednesday, January 20, 2021 Covid-19 Updates, University Of Mississippi Jan 2021

Daily Digest - Wednesday, January 20, 2021 Covid-19 Updates, University Of Mississippi

COVID-19 Website Archives

Campus Update Daily Digest for Wednesday, January 20, 2021


January 19, 2021, University Of Mississippi. Faculty Senate Jan 2021

January 19, 2021, University Of Mississippi. Faculty Senate

Meeting Minutes

Minutes for the January 2021 meeting of the University of Mississippi Faculty Senate.


Rebelwell Offers Burnalong Wellness Classes At Home, Michael Newsom Jan 2021

Rebelwell Offers Burnalong Wellness Classes At Home, Michael Newsom

University of Mississippi News

UM faculty and staff have access to thousands of wellness classes through free membership


January 19, 2021, The Daily Mississippian Jan 2021

January 19, 2021, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.


Prestigious Um Research Center Gets New Director, Shea Stewart Jan 2021

Prestigious Um Research Center Gets New Director, Shea Stewart

University of Mississippi News

Mohammad Al-Hamdan to head National Center for Computational Hydroscience and Engineering


Three Poems, Sophia Terazawa Jan 2021

Three Poems, Sophia Terazawa

Yalobusha Review

No abstract provided.


Around The World In 365 Days, Hannah Thurman Jan 2021

Around The World In 365 Days, Hannah Thurman

Yalobusha Review

No abstract provided.


Full Issue, Journal Editors Jan 2021

Full Issue, Journal Editors

Yalobusha Review

No abstract provided.


Texas Zombie High School, Dan Moreau Jan 2021

Texas Zombie High School, Dan Moreau

Yalobusha Review

No abstract provided.


Full Issue, Journal Editors Jan 2021

Full Issue, Journal Editors

Yalobusha Review

No abstract provided.


Issue 363: January 14-28, 2021, The Local Voice Jan 2021

Issue 363: January 14-28, 2021, The Local Voice

The Local Voice

No abstract provided.


Daily Digest - Wednesday, January 13, 2021 Covid-19 Updates, University Of Mississippi Jan 2021

Daily Digest - Wednesday, January 13, 2021 Covid-19 Updates, University Of Mississippi

COVID-19 Website Archives

Campus Update Daily Digest for Wednesday, January 13, 2021