Digital Commons Network^™

Understanding The Dynamics Of The Structural States Of Cannabinoid Receptors And The Role Of Different Modulators, Anjela Manandhar, Mona H. Haron, Michael L. Klein, Khaled Elokely

Faculty and Student Publications

The cannabinoid receptors CB1R and CB2R are members of the G protein-coupled receptor (GPCR) family. These receptors have recently come to light as possible therapeutic targets for conditions affecting the central nervous system. However, because CB1R is known to have psychoactive side effects, its potential as a drug target is constrained. Therefore, targeting CB2R has become the primary focus of recent research. Using various molecular modeling studies, we analyzed the active, inactive, and intermediate states of both CBRs in this study. We conducted in-depth research on the binding properties of various groups of cannabinoid modulators, including agonists, antagonists, and inverse …

Development Of The Spur Tool: A Profiling Instrument For Patient Treatment Behavior, Béatrice Tugaut, Selam Shah, Kevin Dolgin, Hanna Rebibo Seror, Benoit Arnould, Marie Eve Laporte, Aaron Lee, Lydiane Nabec, Reem Kayyali, Joshua Wells, John D. Piette, Guillaume Hubert

Faculty and Student Publications

Background: Long-term treatment adherence is a worldwide concern, with nonadherence resulting from a complex interplay of behaviors and health beliefs. Determining an individual’s risk of nonadherence and identifying the drivers of that risk are crucial for the development of successful interventions for improving adherence. Here, we describe the development of a new tool assessing a comprehensive set of characteristics predictive of patients’ treatment adherence based on the Social, Psychological, Usage and Rational (SPUR) adherence framework. Concepts from existing self-reporting tools of adherence-related behaviors were identified following a targeted MEDLINE literature review and a subset of these concepts were then selected …

Politicizing The Pandemic: Covid-19 And Its Impact On The Nigerian Economy, John Shola Olanrewaju, Agaptus Nwozor, Ajibola Abdulwasiu Abdulrahaman

Faculty and Student Open Access Publications

This study aims to examine the connection between international politics that characterized the outbreak of COVID-19, mainly between the United States of America and China and the devastating impact of the second wave outbreak on the Nigerian economy. At the initial stage of the pandemic on the Chinese mainland, the economy of China experienced a significant decline. The efficacy of China’s response to COVID-19 led to a fractional economic recovery during the pandemic. However, the internationalization of COVID-19 was greeted with a second wave in most advanced countries, such as the United States of America, Italy, and the United Kingdom, …

Shared Genomic Architectures Of Covid-19 And Antisocial Behavior, Charleen D. Adams, Jorim J. Tielbeek, Brian B. Boutwell

Faculty and Student Publications

Little is known about the genetics of norm violation and aggression in relation to coronavirus disease 2019 (COVID-19). To investigate this, we used summary statistics from genome-wide association studies and linkage disequilibrium score regression to calculate a matrix of genetic correlations (rgs) for antisocial behavior (ASB), COVID-19, and various health and behavioral traits. After false-discovery rate correction, ASB was genetically correlated with COVID-19 (rg = 0.51; P = 1.54E-02) and 19 other traits. ASB and COVID-19 were both positively genetically correlated with having a noisy workplace, doing heavy manual labor, chronic obstructive pulmonary disease, and genitourinary diseases. ASB and COVID-19 …

Issue 408: December 1-15, 2022, The Local Voice

The Local Voice

No abstract provided.

The Influence Of Emotion Regulation And Family Involvement On Diabetes Distress Among Adults With Type 2 Diabetes, Patric J. Leukel, Sophie R. Kollin, Bianca R. Lewis, Aaron A. Lee

Faculty and Student Publications

Adults with diabetes frequently experience diabetes related distress, which is associated with negative health outcomes. Family members are commonly involved in patients’ diabetes self-management. However, family involvement can have helpful and/or harmful effects on patients’ diabetes outcomes. Use of interpersonal strategies to regulate negative emotions may play a role in patients’ interactions with family members and experience of diabetes distress. This study examined the influences of interpersonal emotion regulation and family and friend involvement on diabetes distress among 373 adults with type 2 diabetes. Two separate three-step sequential linear regression models were used to test the main and interactive effects …

Comparative Ubiquitination Proteomics Revealed The Salt Tolerance Mechanism In Sugar Beet Monomeric Additional Line M14, He Liu, Jialin Zhang, Jinna Li, Bing Yu, Sixue Chen, Chunquan Ma, Haiying Li

Faculty and Student Publications

Post-translational modifications (PTMs) are important molecular processes that regulate organismal responses to different stresses. Ubiquitination modification is not only involved in human health but also plays crucial roles in plant growth, development, and responses to environmental stresses. In this study, we investigated the ubiquitination proteome changes in the salt-tolerant sugar beet monomeric additional line M14 under salt stress treatments. Based on the expression of the key genes of the ubiquitination system and the ubiquitination-modified proteins before and after salt stress, 30 min of 200 mM NaCl treatment and 6 h of 400 mM NaCl treatment were selected as time points. …

Effects Of Feeding Mode On The Performance, Life Span And Greenhouse Gas Emissions Of A Vertical Flow Macrophyte Assisted Vermifilter, Rajneesh Singh, Chittaranjan Ray, Daniel N. Miller, Lisa M. Durso, Yulie Meneses, Shannon Bartelt-Hunt, Matteo D’Alessio

Faculty and Student Publications

This study was conducted to investigate the impact of intermittent feeding on performance, clogging, and gaseous emission on macrophyte assisted vermifiltration (MAVF) based treatment system. Synthetic slaughterhouse wastewater was applied to two different integrated vertical flow based MAVFs. Triplicates were used throughout the study. Eisenia fetida earthworms were added to MAVFs, and Carex muskingmenis plants were planted. Wastewater was applied to the reactors on 1) intermittent (8 h/day) (IMAVF) and 2) continuous (24 h/day) (CMAVF) basis. The average chemical oxygen demand, total nitrogen, and total phosphorous removals achieved by the IMAVF were 80.2 ± 1.6%, 53.9 ± 1.3% and 66.5 …

South-To-North Migration Preceded The Advent Of Intensive Farming In The Maya Region, Douglas J. Kennett, Mark Lipson, Keith M. Prufer, David Mora-Marín, Richard J. George, Nadin Rohland, Mark Robinson, Willa R. Trask, Heather H. J. Edgar, Ethan C. Hill, Erin E. Ray, Paige Lynch, Emily Moes, Lexi O’Donnell, Thomas K. Harper, Emily J. Kate, Josue Ramos, John Morris, Said M. Gutierrez

Faculty and Student Publications

The genetic prehistory of human populations in Central America is largely unexplored leaving an important gap in our knowledge of the global expansion of humans. We report genome-wide ancient DNA data for a transect of twenty individuals from two Belize rock-shelters dating between 9,600-3,700 calibrated radiocarbon years before present (cal. BP). The oldest individuals (9,600-7,300 cal. BP) descend from an Early Holocene Native American lineage with only distant relatedness to present-day Mesoamericans, including Mayan-speaking populations. After ~5,600 cal. BP a previously unknown human dispersal from the south made a major demographic impact on the region, contributing more than 50% of …

Scholarship Program Gains New Chair, Member, Jonathan Scott

University of Mississippi News

No abstract provided.

Evaluating Pedestrian Service Of The New Super Diverging Diamond Interchange On Three Case Study Sites In Denver, Colorado, Muhammad Tahmidul Haq, Amirarsalan Mehrara Molan, Khaled Ksaibati

Faculty and Student Publications

Ensuring safe and comfortable conditions for pedestrians necessitates specific strategies at intersections and service interchanges where traffic and pedestrians interact in complex ways with other modes of transportation. This study aims to investigate pedestrian performance at the new Super Diverging Diamond Interchange (Super DDI) using real-world locations (i.e., I-225 and Mississippi Ave, I-25 and 120th Ave, and I-25 and Hampden Ave in Denver, Colorado). Three alternative designs, typical DDI, and two versions of Super DDI were considered to make a reasonable comparison with the existing Conventional Diamond Interchange (CDI). A comprehensive series of simulation models (192 scenarios with 960 runs) …

Recombinant Simian Varicella Virus-Simian Immunodeficiency Virus Vaccine Induces T And B Cell Functions And Provides Partial Protection Against Repeated Mucosal Siv Challenges In Rhesus Macaques, Bapi Pahar, Wayne Gray, Marissa Fahlberg, Brooke Grasperge, Meredith Hunter, Arpita Das, Christopher Mabee, Pyone Pyone Aye, Faith Schiro, Krystle Hensley, Aneeka Ratnayake, Kelly Goff, Celia Labranche, Xiaoying Shen, Georgia D. Tomaras, C. Todd Demarco, David Montefiori, Patricia Kissinger, Preston A. Marx

Faculty and Student Publications

HIV vaccine mediated efficacy, using an expanded live attenuated recombinant varicella virus-vectored SIV rSVV-SIVgag/env vaccine prime with adjuvanted SIV-Env and SIV-Gag protein boosts, was evaluated in a female rhesus macaques (RM) model against repeated intravaginal SIV challenges. Vaccination induced anti-SIV IgG responses and neutralizing antibodies were found in all vaccinated RMs. Three of the eight vaccinated RM remained uninfected (vaccinated and protected, VP) after 13 repeated challenges with the pathogenic SIVmac251-CX-1. The remaining five vaccinated and infected (VI) macaques had significantly reduced plasma viral loads compared with the infected controls (IC). A significant increase in systemic central memory CD4+ T …

Money Moves: An Analysis Of Chinese Foreign Direct Investment In Europe, Susan Soh

Honors Theses

In recent years, China has begun engaging in outward foreign direct investment (FDI). There is a significant amount of literature dedicated to understanding China’s FDI in developing nations. However, very little research has been conducted over Chinese FDI in advanced economies. As a result of this gap in existing literature, the question arises, what explains Chinese FDI in Europe?

As FDI is a transaction to which both the donor and recipient countries must agree, this thesis has a dual focus. One chapter of the thesis analyzes the effects of and motivations for Chinese FDI on European nations. In this chapter, …

The Development Of Labor Law In Outer Space: A Comparison With The American Frontier And The High Seas, Connor Hogan

Journal of Space Law

No abstract provided.

December 1, 2022, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

University Expanding Food Rx Program, Edwin B. Smith

University of Mississippi News

USDA awards $500K to assist with providing food for Quitman County residents

University Expanding Food Rx Program, Edwin B. Smith

University of Mississippi News

USDA awards $500K to assist with providing food for Quitman County residents

Indirectly And Directly Involved Students' Perspectives On Multi-Modal Communication Treatment In Persons With Aphasia, Emily Lewis

Honors Theses

Our study investigated the perspectives of students who were either directly or indirectly involved in the Multi-modal communication treatment (MCT) sessions for persons with aphasia. Two undergraduate and two graduate students were recruited from the University of Mississippi who participated in the MCT sessions. We collected their perspectives through semi-structured interviews and used thematic qualitative analysis to analyze our data. We reported themes from the indirectly involved students and the directly involved students and compared how the themes were similar and different between the indirectly and directly involved students. We discussed that both direct and indirect experience for clinical therapy …

Top Croft Students Awarded Scholarships, Erin Garrett

University of Mississippi News

Institute celebrates 25 years of supporting international studies majors

Small-Molecule Protac Mediates Targeted Protein Degradation To Treat Stat3-Dependent Epithelial Cancer, Jinmei Jin, Yaping Wu, Zeng Zhao, Ye Wu

Faculty and Student Publications

The aberrant activation of STAT3 is associated with the etiology and progression in a variety of malignant epithelial-derived tumors, including head and neck squamous cell carcinoma (HNSCC) and colorectal cancer (CRC). Due to the lack of an enzymatic catalytic site or a ligand-binding pocket, there are no small-molecule inhibitors directly targeting STAT3 that have been approved for clinical translation. Emerging proteolysis targeting chimeric (PROTAC) technology-based approach represents a potential strategy to overcome the limitations of conventional inhibitors and inhibit activation of STAT3 and downstream genes. In this study, the heterobifunctional small-molecule-based PROTACs are successfully prepared from toosendanin (TSN), with 1 …

Disruption To Ems Service During Flood Scenarios In Western North Carolina, Julia Cardwell

Journal of Rural Social Sciences

Given that the intensity and frequency of flood events will increase under climate change scenarios, the ability to model potential impacts, such as those to healthcare access, will become increasingly important. This study analyzes EMS response time under both a historical (Tropical Storm Fred in August 2021) and a modeled flood event (FEMA’s 100-yr floodplain) in western North Carolina, a predominantly rural area. The results indicate that network disruption during flood events is a concern in the study area, and while the historical event produced moderate disruption, the 100-yr event produced major disruptions throughout the study area. This research emphasizes …

Ole Miss, Msu Cadets Leg 100 Miles For Egg Bowl Run, Clara Turnage

University of Mississippi News

ROTC students relayed from Starkville to Oxford to deliver game ball

Issue 407: November 21-December 1, 2022, The Local Voice

The Local Voice

No abstract provided.

Making An Impact Today And Tomorrow, Bill Dabney

University of Mississippi News

No abstract provided.

November 17, 2022, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Bridging The Divide: Connecting Urban And Rural Care Through The Right! From The Start Initiative, Tess Lefmann, Sannie Snell, Mobolaji E. Famuyide, Sushmitha Inguva, John J. Green

Journal of Rural Social Sciences

Disparities in health and barriers to healthcare are prominent in rural areas, particularly in the Delta region of Mississippi where high rates of premature births, infant mortality, low weight births, and maternal mortality exacerbate the dearth of access to care. Extending the reach of healthcare providers and services between urban and rural areas is of utmost importance in improving the landscape of maternal and child health. Community health workers (CHWs), trusted individuals in the community, play a valuable role in this through social support. This research note delineates the importance of community health workers as connectors in establishing a trusted …

Luncheon Speakers Encourage Women To Aim For Leadership, Stephanie Mortimer

University of Mississippi News

Successful executives join UM event to share experiences, insights

Student Learns Law, Language During Summer Internship, Sydney Pender

University of Mississippi News

Savannah Whitmore is first Ole Miss student to participate in German American Exchange program

November 10, 2022, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Open Meeting Minutes — November 10-11, 2022, American Institute Of Certified Public Accountants. Professional Ethics Division. Professional Ethics Executive Committee

Association Sections, Divisions, Boards, Teams

No abstract provided.