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The French Divorcee And Her Evolution, Mackenzie Bialzik
The French Divorcee And Her Evolution, Mackenzie Bialzik
Honors Theses
This thesis serves to explore the greater questions concerning patterns of divorce in France and how women, through divorce, experienced greater liberties within the law. The evidence used in this paper stems mainly from demographic data, opinion pieces on divorce, and legal journals. While I had hoped to access specific divorce hearings, privacy laws in France and the language barrier prevented me from this type of research. Through my research I have found that divorce did not follow typical trends in feminist movements as expected in France. Instead, divorce was reactionary of the social perceptions of marriage and gender. Additionally, …
April 18, 2024, The Daily Mississippian
April 18, 2024, The Daily Mississippian
Daily Mississippian (all digitized issues)
No abstract provided.
Mocra And The New Cosmetics Gmps, Brandi Reinbold
Mocra And The New Cosmetics Gmps, Brandi Reinbold
Oxford ICSB
The Modernization of Cosmetics Regulation Act (MoCRA) enacted by Congress December 29th, 2022, includes provisions for the FDA to publish proposed Good Manufacturing Practice (GMP) regulations by the end of 2024 and a final rule by the end of 2025. In this talk we will explore what the language of MoCRA tells us about what GMPs are likely to be promulgated with a focus on GMPs related to ingredient and finished product identity and purity. MoCRA exempts small cosmetics manufacturers from GMP compliance requirements and directs FDA to “take it easy” on other not-quite-so-small manufacturers. Despite these exemptions, most cosmetics …
Session E Overview Of The U.S. Cosmetics Regulatory Framework, Jannavi Srinivasan
Session E Overview Of The U.S. Cosmetics Regulatory Framework, Jannavi Srinivasan
Oxford ICSB
Cosmetic products in the U.S. has been regulated by the Food and Drug Administration (FDA) according to the Federal Food, Drug, and Cosmetic Act which has provided for FDA’s regulation of cosmetics since 1938. The Modernization of Cosmetics Regulation Act (MoCRA), enacted in December of 2022, significantly expanded and reformed regulations overseeing cosmetics in the U.S. Included in MoCRA among other provisions, are facility registration and product listing, reporting of serious adverse events, and a requirement that FDA propose a rule for good manufacturing practices. This presentation will provide an overview of cosmetics regulations including the major provisions of MoCRA …
Impact Of Mocra When Assessing Botanical Safety, Rick Kingston
Impact Of Mocra When Assessing Botanical Safety, Rick Kingston
Oxford ICSB
The Modernization of Cosmetics Regulation Act of 2022 (MoCRA) became effective December 29th, 2023. MoCRA is the most significant expansion of FDA’s authority to regulate cosmetics since the Federal Food, Drug, and Cosmetic (FD&C) Act was enacted in 1938. MoCRA expands the FDA's rulemaking and enforcement authority over cosmetics and creates new compliance obligations for manufacturers. There are six key areas of the legislation including Facility Registration, Product & Ingredient Listing, Safety Substantiation, Cosmetics Labeling, and Adverse Event Reporting and Record Keeping. Each of these areas has significant implications for manufacturers and the ingredients commonly found in cosmetics. Given the …
Short & Long-Term Consequences Of Cannabis Intake & Differences Between Occasional & Chronic Frequent Cannabis Use, Marilyn Huestis
Short & Long-Term Consequences Of Cannabis Intake & Differences Between Occasional & Chronic Frequent Cannabis Use, Marilyn Huestis
Oxford ICSB
As the medicalization and legalization of the United States continues to increase it is important to understand the short- and long-term consequences of cannabis use. The endogenous cannabinoid neurotransmitter system is critical for the appropriate functioning of survival functions including hunger, body temperature control, memory and reproduction. When individuals use cannabis, they hijack the normal functioning of the system that attempts to maintain homeostasis. The most important short-term consequence of cannabis use is the morbidity and mortality of driving under the influence of cannabis. Also, legalization reduced the perception of risk of using cannabis that leads to higher adolescent and …
A New Way Forward For Cannabidiol (Cbd) And Other Hemp Products, Patrick Cournoyer
A New Way Forward For Cannabidiol (Cbd) And Other Hemp Products, Patrick Cournoyer
Oxford ICSB
The FDA announced that existing regulatory frameworks for foods and supplements are not appropriate for cannabidiol (CBD). Given the available evidence, it is not apparent how CBD products could meet safety standards for dietary supplements or food additives. A new regulatory pathway for CBD is needed that balances individuals’ desire for access to CBD products with the regulatory oversight needed to manage risks.
Opening Remarks For “Cannabis: Current Status And Future Outlook”, Cassandra Taylor
Opening Remarks For “Cannabis: Current Status And Future Outlook”, Cassandra Taylor
Oxford ICSB
No abstract provided.
Researchers Review Reasoning For Nordic Ashwagandha Ban, Clara Turnage
Researchers Review Reasoning For Nordic Ashwagandha Ban, Clara Turnage
University of Mississippi News
OXFORD, Miss. – Two University of Mississippi researchers are seeking to find out why three Nordic countries are attempting to ban ashwagandha.
Biological Activity Of Essential Oils – Focus On Antibiotic Resistance, Gyorgyi Horvath
Biological Activity Of Essential Oils – Focus On Antibiotic Resistance, Gyorgyi Horvath
Oxford ICSB
No abstract provided.
Natural Products Ireland: From Bioactives To The Bioeconomy - A Systems-Based Approach, Gaia Scalabrino
Natural Products Ireland: From Bioactives To The Bioeconomy - A Systems-Based Approach, Gaia Scalabrino
Oxford ICSB
Natural Products (NP) are on the rise across the world, driven by economic, environmental, health and societal needs. An increasing focus has been placed on the role of boglands within climate change as peatlands store 1/3 of the world’s soil carbon and provide water storage. With our project ‘Unlocking Nature’s Pharmacy’ we aim to increase public awareness and drive Ireland towards a bioeconomy where Natural Product Science (NPS) plays a key role. At the NatPro Centre, the Trinity Centre for Natural Products Research, we use systems-based approaches (SBA), for example looking at the bogs of Ireland, to identify innovative bio-based …
Cold-Water Extract Of Nerium Oleander Leaves Inhibits Cancer: From Bench To Bedside, Thomas Efferth, Luay J. Rashan, Nadire Özenver, Joelle C. Boulos, Mona Dawood, Wynand P. Roos, Katrin Katrin, Ioannis Ioannis, Ludger A. Wessjohann, Heinz-Herbert Fiebig
Cold-Water Extract Of Nerium Oleander Leaves Inhibits Cancer: From Bench To Bedside, Thomas Efferth, Luay J. Rashan, Nadire Özenver, Joelle C. Boulos, Mona Dawood, Wynand P. Roos, Katrin Katrin, Ioannis Ioannis, Ludger A. Wessjohann, Heinz-Herbert Fiebig
Oxford ICSB
Nerium oleander is a well-known medicinal plant used in the Mediterranean region and traditional Indian medicine (Ayurveda) against a variety of diseases, including cancer. We investigated a cold-water extract of N. oleander leaves for their anticancer activities in vitro and in vivo. The cytotoxicity testing in the Oncotest panel of tumor cell lines and concomitant COMPARE analysis showed a high degree of similarity to mitosis-inhibiting compounds. We verified this hypothesis by treating tumor cells transfected with a tubulin-GFP fusion cDNA construct and confocal microscopy as well as a biochemical tubulin polymerization assay. N. oleander showed a similar inhibition of tubulin …
African Plants In Jamaican Farms And Gardens, Thera Edwards
African Plants In Jamaican Farms And Gardens, Thera Edwards
Oxford ICSB
Plants of all growth forms and regeneration strategies were introduced to Jamaica by European slavers and by Enslaved Africans. Some species such as Tamarind used to purify drinking water on ships arrived through purposes of practicality while others that such as yam and plantain were transported as food supplies on the ships or by the Enslaved Africans as tubers for planting in their countries of destination. Tuber crops proved to be invaluable in hurricane prone islands such as Jamaica as the underground tuber was left undamaged by the high winds of the storms. Other crops such as Plantain while not …
Fda Investigational New Drug (Ind) Applications, Cassandra Taylor
Fda Investigational New Drug (Ind) Applications, Cassandra Taylor
Oxford ICSB
Current Federal law requires that a drug be the subject of an approved marketing application before it is transported or distributed across state lines. Because a sponsor will probably want to ship the investigational drug to clinical investigators in many states, it must seek an exemption from that legal requirement. The IND is the means through which the sponsor technically obtains this exemption from the FDA. During a new drug's early preclinical development, the sponsor's primary goal is to determine if the product is reasonably safe for initial use in humans, and if the compound exhibits pharmacological activity that justifies …
Introduction To The Premarket Review Of Human Food Ingredients In The United States And Concepts In The Safety Assessment Of Novel Plant-Derived Ingredients, Troy Hubbard
Oxford ICSB
Premarket regulation of ingredients added to food is a key pillar ensuring the safety of food as it allows the opportunity to address potential safety concerns prior to consumer exposure. In the United States, food and color additives are substances that are intentionally added to food and are subject to pre-market approval by the Food and Drug Administration (FDA) and require a listing in the Code of Federal Regulations, unless the intended use of the substance is generally recognized as safe (GRAS), among qualified experts. GRAS is not an inherent property of a substance, as is often misunderstood; rather, it …
Natural Products In Food And Agriculture, Stephen O. Duke
Natural Products In Food And Agriculture, Stephen O. Duke
Oxford ICSB
Before the National Center for Natural Products Research (NCNPR) existed, I was Director of a USDA weed management lab. Two of my interests were natural products as herbicides and the chemical ecology of weed/crop interactions (allelopathy). Dr. James McChesney and I had several conversations about his vision for the NCNPR on the University of Mississippi campus. I was very interested in becoming a part of this, as his plan was to have a USDA lab that would study natural products for use in food and agriculture as part of the center. The USDA Agricultural Research Service established the Natural Product …
Preventing Ingredient Adulteration To Maintain Botanical Integrity, Katie Banaszewski
Preventing Ingredient Adulteration To Maintain Botanical Integrity, Katie Banaszewski
Oxford ICSB
The growing popularity of botanical products combined with the challenges of the supply chain to meet the ingredient demand has created opportunities for dishonest companies to take advantage of their clients for financial gain. Suppliers and manufacturers must comply with cGMPs (current Good Manufacturing Practices), specifically when it comes to the basic requirements of properly identifying crude botanicals in whole, cut, or powdered form, as well as botanical extracts and essential oils. Despite this regulatory requirement, a large portion of botanical ingredients and products sold in the marketplace are adulterated. Popular ingredients in high demand are intentionally substituted, diluted, or …
African & Caribbean Herbal Pharmacopieae - Curating Data For Product Development, David Katerere
African & Caribbean Herbal Pharmacopieae - Curating Data For Product Development, David Katerere
Oxford ICSB
This presentation aims to provide a comprehensive examination of the Africa Herbal Pharmacopoeia (AHP) and the Caribbean Herbal Pharmacopoeia (CHP), highlighting their respective similarities and differences in the realm of traditional herbal medicine and product development. Both pharmacopoeias are important initiatives in curating indigenous knowledge related to medicinal plants. They are valuable resources for researchers, healthcare practitioners, and industry. This presentation will outline the methodological and logistical approaches employed in putting together monographs and the challenges faced. Furthermore, the comparative analysis will explore the regional nuances that shape the content of each pharmacopoeia, considering factors such as local traditions, ecological …
Chemistry, Biology, And Safety Of Volatile Organics From Aromatic And Medicinal Plants, Nicole Stevens
Chemistry, Biology, And Safety Of Volatile Organics From Aromatic And Medicinal Plants, Nicole Stevens
Oxford ICSB
Introduction Sleep is an important foundation of health, yet the U.S. Centers for Disease Control (CDC) notes that about 30% of adults to not get the recommended minimum of 7 hours’ sleep per night. Prescription treatments may help, but they carry risks such as side-effects, dependency, and medication interaction. Natural botanical extracts are a therapeutic possibility for improving sleep quality, but additional research is needed on their efficacy and safety. A system of natural products based on lavender was developed and tested in a human clinical study to evaluate effect on sleep, blood and safety markers, and gene expression modulation …
Adulteration - Why Does It Still Proliferate?, John Travis
Adulteration - Why Does It Still Proliferate?, John Travis
Oxford ICSB
No abstract provided.
A Survey Of Melatonin In Dietary Supplement Products Sold In The U.S., Rahul Pawar
A Survey Of Melatonin In Dietary Supplement Products Sold In The U.S., Rahul Pawar
Oxford ICSB
In the United States, melatonin products are widely available to consumers as dietary supplements. During the past few decades, melatonin products have gained increased popularity primarily as a sleep aid, with a variety of product forms available for different age groups of consumers. Recent reports have highlighted a rise in melatonin ingestion among children reported to poison control centers across the U.S. The increased use of melatonin-containing dietary supplements and reported deviation from labeled quantities has emphasized the need for additional research to better understand products in the marketplace.
The objective of this work was to measure the melatonin content …
Challenges Of Building Specifications For Essential Oils: An Industry Perspective, Brett Smith
Challenges Of Building Specifications For Essential Oils: An Industry Perspective, Brett Smith
Oxford ICSB
The rise in essential oil popularity is creating unprecedented demand worldwide. With the increased demand, the worldwide supply chain is challenged with maintaining consistent quality standards. Some essential oil producers may be motivated to use new and innovative methods to alter their products to meet quality standards and extend their current oil supplies. Climate change is also affecting growing season conditions, leading to changes in essential oil composition compared to past harvests. These factors create challenges for industry in establishing updated quality and commerce specifications beyond traditional ISO, AFNOR, and pharmacopoeia standards for essential oils. To meet these supply chain …
Characterization Of Ashwagandha Using A Multi-Detector Approach, Vincent Sica
Characterization Of Ashwagandha Using A Multi-Detector Approach, Vincent Sica
Oxford ICSB
Botanicals are complex mixtures that present unique analytical challenges. A multi-detector chromatographic approach can provide accurate, constituent-based data to ensure proper identification and quantification of botanicals. These data are often used to help drive in silico safety assessments to identify suspected toxicants and assess the potential for deleterious effects using structure activity relationships. To showcase this approach, ashwagandha extracts were characterized to determine authenticity and to guide the necessary toxicological studies. To ensure the full constituency of the extracts are evaluated, a multi-detector system (UHPLC-PDA-CAD-HRMS) was employed and subjected to a comprehensive chemical constituent identification (CCID) process. All of the …
Understanding Plant To Extract Ratios Of Botanical Extracts And Their Implications In Product Labeling, Maria Monagas, Thomas Brendler, Josef Brinckmann, Steven Dentali, Stefan Gafner, Gabriel Giancaspro, Holly Johnson, James Kababick, Cuiying Ma, Hellen Oketch-Rabah, Pilar Pais, Nandu Sarma, Robin Marles
Understanding Plant To Extract Ratios Of Botanical Extracts And Their Implications In Product Labeling, Maria Monagas, Thomas Brendler, Josef Brinckmann, Steven Dentali, Stefan Gafner, Gabriel Giancaspro, Holly Johnson, James Kababick, Cuiying Ma, Hellen Oketch-Rabah, Pilar Pais, Nandu Sarma, Robin Marles
Oxford ICSB
Dietary supplement current good manufacturing practice (cGMP) in the U.S. requires the establishment of quality parameters for each component used in the manufacture of a dietary supplement to ensure that specifications for the identity, purity, strength, composition, and limits on contaminants are met using scientifically valid methods of analysis. However, specifications for botanical extracts (including fungal and algal extracts) routinely include additional data that are not amenable to verification through analytical methods. Such descriptive information may include Plant to Extract ratios, which are ratios of the quantity of botanical article used in the manufacture of the extract to the quantity …
The True History Of Aloes And Beyond, Ben-Erik Van Wyk
The True History Of Aloes And Beyond, Ben-Erik Van Wyk
Oxford ICSB
The recorded history of aloes dates back thousands of years, with early recordings in the Papyrus Ebers (ca. 1550 B.C.) and in Dioscorides’s Herbal (1st cent. A.D.). Aloe has been used as a two-in-one medicine, not only by early explorers but also as a material of strategic military importance, with the yellow juice effective against the stomach problems of an army on the march and the white juice (gel) used to treat the wounds of battle. Aloe vera is the correct name for the “true aloe”, as the specific epithet “vera” indicates. The origins of the plant are shrouded in …
One-Class Modeling For The Authentication Of Actaea Racemosa And Evaluation Of The Variation Between Botanical Reference Materials, James Harnly
Oxford ICSB
One-class modeling based on soft independent modeling of class analogy (SIMCA) is a simple but powerful method for comparing the chemical composition of botanical materials using non-targeted chromatograms (GC, LC) or spectra (IR, MS, NIR, NMR). The methodology is available on any commercial chemometric platform. Authentication is based solely on the characteristics of the botanical material of interest. Detection of adulteration is determined for each variable and requires no identification of adulterants. Some highly characterized botanical reference materials (BRMs) may account for species, cultivar, and year and location of harvest while more generic BRMs may have minimal characterization. All of …
Botanical Education In The Us In The Post-Dshea Era (1994-2024), Loren Israelsen
Botanical Education In The Us In The Post-Dshea Era (1994-2024), Loren Israelsen
Oxford ICSB
No abstract provided.
04.15.2024 Orsp Connect, Liz Williamson
04.15.2024 Orsp Connect, Liz Williamson
ORED Newsletter
DMP Tool, Jeff Neal, new training module: Budget Basics, new policy Maligned Foreign Talent Recruitment
University Names Inaugural Faculty Laureates, Edwin Smith
University Names Inaugural Faculty Laureates, Edwin Smith
University of Mississippi News
OXFORD, Miss. – A faculty jury has chosen Stephen Fafulas, associate professor of Spanish and linguistics, and Amanda Winburn, associate professor of leadership and counselor education, as the first two honorees in an innovative new program designed to introduce the state to the creative faculty who research and teach at the University of Mississippi.
Evaluation Of Seizure Recognition And First Aid Training Course And Improving Self-Efficacy Related To Medical Emergencies In Mississippi, Anna Katherine Herrington, Collin Earl Wayne Crawson, Daniel Robert Zuckerman
Evaluation Of Seizure Recognition And First Aid Training Course And Improving Self-Efficacy Related To Medical Emergencies In Mississippi, Anna Katherine Herrington, Collin Earl Wayne Crawson, Daniel Robert Zuckerman
Honors Theses
Within recent years, there has been increased attention to the growing physician shortage across the United States. This shortage has placed substantial strain upon regions of lower healthcare access, particularly those of rural regions such as much of the state of Mississippi. As rural healthcare providers are placed under more strenuous conditions, they encounter issues of increased patient volume, lack of a trauma team, or adequate transportation to higher-level care facilities. These issues may exacerbate the present inequities in cost of living, access to adequate healthcare, and the distress caused by these concerns. Individuals with epilepsy are one cohort with …