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The Counteracting Effects Of Exercise On High-Fat Diet-Induced Memory Impairment: A Systematic Review, Paul D. Loprinzi, Pamela Ponce, Liye Zou, Hong Li Jan 2019

The Counteracting Effects Of Exercise On High-Fat Diet-Induced Memory Impairment: A Systematic Review, Paul D. Loprinzi, Pamela Ponce, Liye Zou, Hong Li

Faculty and Student Publications

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. The objective of the present review was to evaluate whether exercise can counteract a potential high-fat diet-induced memory impairment effect. The evaluated databases included: Google Scholar, Sports Discus, Embase/PubMed, Web of Science, and PsychInfo. Studies were included if: (1) an experimental/intervention study was conducted, (2) the experiment/intervention included both a high-fat diet and exercise group, and evaluated whether exercise could counteract the negative effects of a high-fat diet on memory, and (3) evaluated memory function (any type) as the outcome measure. In total, 17 articles met the inclusionary criteria. All 17 …

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The Effects Of High-Intensity Interval Exercise And Hypoxia On Cognition In Sedentary Young Adults, Shengyan Sun, Paul D. Loprinzi, Hongwei Guan, Liye Zou, Zhaowei Kong, Yang Hu, Qingde Shi, Jinlei Nie Jan 2019

The Effects Of High-Intensity Interval Exercise And Hypoxia On Cognition In Sedentary Young Adults, Shengyan Sun, Paul D. Loprinzi, Hongwei Guan, Liye Zou, Zhaowei Kong, Yang Hu, Qingde Shi, Jinlei Nie

Faculty and Student Publications

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Background and Objectives: Limited research has evaluated the effects of acute exercise on cognition under different conditions of inspired oxygenation. Thus, the purpose of this study was to examine the effects of high-intensity interval exercise (HIE) under normoxia (inspired fraction of oxygen (FIO2): 0.209) and moderate hypoxia (FIO2: 0.154) on cognitive function. Design: A single-blinded cross-over design was used to observe the main effects of exercise and oxygen level, and interaction effects on cognitive task performance. Methods: Twenty inactive adults (10 males and 10 females, 19–27 years old) performed a cognitive …

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In Situ Gel Of Triamcinolone Acetonide-Loaded Solid Lipid Nanoparticles For Improved Topical Ocular Delivery: Tear Kinetics And Ocular Disposition Studies, Akshaya Tatke, Narendar Dudhipala, Karthik Yadav Janga, Sai Prachetan Balguri, Bharathi Avula, Monica M. Jablonski, Soumyajit Majumdar Jan 2019

In Situ Gel Of Triamcinolone Acetonide-Loaded Solid Lipid Nanoparticles For Improved Topical Ocular Delivery: Tear Kinetics And Ocular Disposition Studies, Akshaya Tatke, Narendar Dudhipala, Karthik Yadav Janga, Sai Prachetan Balguri, Bharathi Avula, Monica M. Jablonski, Soumyajit Majumdar

Faculty and Student Publications

© 2019 The Authors Objective: The purpose of this systematic review is to summarize the best available evidence on interventions that could be implemented in the college environment to increase HPV vaccination uptake in college students who were not previously vaccinated. Methods: Pubmed, CINAHL, PsycINFO, Cochrane, and EBSCO were searched in December 2017 to identify all literature meeting the following criteria: human subjects, English language, HPV, HPV vaccination, and college. PRISMA recommendations were followed. We focused only on manuscripts that reported vaccine uptake, excluding studies that only reported vaccine intentions. We identified 2989 articles; 101 relevant after screening; nine eligible …

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Pituitary Gland Functional Connectivity And Bmi, Paige Rucker, Toshikazu Ikuta Jan 2019

Pituitary Gland Functional Connectivity And Bmi, Paige Rucker, Toshikazu Ikuta

Faculty and Student Publications

The pituitary gland (PG) influences body weight through hormonal releases; however, the relation between body weight and PG’s co-activities with other brain regions remains unclear. Here, we aimed to identify (1) the functional connectivity of the PG and (2) PG functional connectivity associated with body mass index by examining resting state functional magnetic imaging (rsfMRI) data. Using enhanced Nathan Kline Institute-Rockland Sample, PG functional connectivity of 494 individuals was analyzed to assess in voxel-wise fashion. A negative association was found between BMI and PG functional connectivity with the orbitofrontal cortex, hippocampus, putamen and temporal lobe. Our results show PG dysconnectivity …

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The Role Of Glacial-Interglacial Climate Change In Shaping The Genetic Structure Of Eastern Subterranean Termites In The Southern Appalachian Mountains, Usa, Chaz Hyseni, Ryan C. Garrick Jan 2019

The Role Of Glacial-Interglacial Climate Change In Shaping The Genetic Structure Of Eastern Subterranean Termites In The Southern Appalachian Mountains, Usa, Chaz Hyseni, Ryan C. Garrick

Faculty and Student Publications

Abstract: The eastern subterranean termite, Reticulitermes flavipes, currently inhabits previously glaciated regions of the northeastern U.S., as well as the unglaciated southern Appalachian Mountains and surrounding areas. We hypothesized that Pleistocene climatic fluctuations have influenced the distribution of R. flavipes, and thus the evolutionary history of the species. We estimated contemporary and historical geographic distributions of R. flavipes by constructing Species Distribution Models (SDM). We also inferred the evolutionary and demographic history of the species using mitochondrial (cytochrome oxidase I and II) and nuclear (endo-beta-1,4-glucanase) DNA sequence data. To do this, genetic populations were delineated using Bayesian spatial-genetic clustering, competing …

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The Effects Of Physical Exercise On Parahippocampal Function, P. D. Loprinzi Jan 2019

The Effects Of Physical Exercise On Parahippocampal Function, P. D. Loprinzi

Faculty and Student Publications

© 2019 The Author(s). Objective: The objective of this study was to examine the effects of physical exercise on parahippocampal function. Methods: Studies were identified using electronic databases, including PubMed, PsychInfo, Sports Discus, and Google Scholar. In total, 28 articles met the inclusionary criteria. Among these, 20 were among humans and 8 in animal models. Among the 20 human studies that examined some aspects of the parahippocampal gyrus, 5 evaluated the entorhinal cortex and 1 evaluated the perirhinal cortex. Among the 20 human studies, 3 evaluated neural activity (or BOLD-signal changes), 14 evaluated brain volume (gray or white matter), 2 …

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A Mechanistic Study Of The Teratogenic Potential Of 4-O-Methylhonokiol (Mh) On Japanese Medaka (Oryzias Latipes), Santu Kumar Singha Jan 2019

A Mechanistic Study Of The Teratogenic Potential Of 4-O-Methylhonokiol (Mh) On Japanese Medaka (Oryzias Latipes), Santu Kumar Singha

Electronic Theses and Dissertations

An additional goal of this project was to characterize the Wnt/β-catenin signaling pathway to unravel the adverse potential of MH on the cardiovascular system (CVS). Our study suggested that MH-mediated cardiovascular injury may be caused due to upregulation of some major components of the Wnt/β-catenin pathway through expression of excessive pro-inflammatory mediators. Moreover MH decreased expression of ErbB3 and NRG-2 suggesting impaired cardiac structure. MH exposure caused a slow heartbeat blood occlusion absence of blood circulation decreased hatching efficiency and increased mortality in medaka embryos in a concentration- and time-dependent manner. MH might cause blood vessel occlusion by increasing the …

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Examining The Role Of Reproductive Interference In The Decline Of Native Green Treefrogs Following Cuban Treefrog Invasions, Joseph Kennedy Jan 2019

Examining The Role Of Reproductive Interference In The Decline Of Native Green Treefrogs Following Cuban Treefrog Invasions, Joseph Kennedy

Electronic Theses and Dissertations

Reproductive interference occurs when the mating behaviors of one species negatively impact the fitness of another species. It is of increasing interest in invasive species biology because the introduction of alien species often leads to novel sexual interactions with native taxa, which can contribute to their decline. I examined whether reproductive interference plays a role in the decline of native green treefrogs (Hyla cinerea) following invasions of Cuban treefrogs (Osteopilus septentrionalis) in the southeastern United States. The impetus for this study revolves around similarities in spectro-temporal features of Cuban treefrog courtship calls and green treefrog aggressive calls. The significance of …

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Safety Assessment And Chemical Fingerprint Analysis Of Medicinal Plants Commonly Consumed As Herbal Teas; Rooibos (Aspalathus Linearis) And Moringa (Moringa Oleifera), Omer I. Fantoukh Jan 2019

Safety Assessment And Chemical Fingerprint Analysis Of Medicinal Plants Commonly Consumed As Herbal Teas; Rooibos (Aspalathus Linearis) And Moringa (Moringa Oleifera), Omer I. Fantoukh

Electronic Theses and Dissertations

The first chapter discusses the significance of natural products, safety challenges, and quality issues concisely. Specifically, the impact of herb-drug interaction on consumers and the quest for chemical markers for chemical fingerprinting development are provided. Rooibos tea (Aspalathus linearis) is a popular South African herbal tea enjoyed worldwide. Limited reports indicate the potential of rooibos tea to alter the activity of CYP450 isozymes. In chapter two, the phytochemical investigation of A. linearis resulted in the isolation and characterization of 14 phenolic compounds. Safety assessment of the phytochemicals through interaction with CYP, PXR, and P gp was conducted. The …

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Identifying Transcription Co-Regulators Of Gcm/Repo In The Development Of Glia In Drosophila Melanogaster, Glendin Kostantinos Pano Jan 2019

Identifying Transcription Co-Regulators Of Gcm/Repo In The Development Of Glia In Drosophila Melanogaster, Glendin Kostantinos Pano

Electronic Theses and Dissertations

The molecular mechanism mediating the differentiation of neural progenitors to either glia or neurons is guided by the gene glial cells missing (gcm), a master regulator of glial cell differentiation. Knockout of this transcription factor (TF) and its homolog gcm2 in the fruit fly Drosophila Melanogaster results in embryos that develop neurons in place of lateral glia. Conversely, overexpression of gcm in those neural progenitors results in embryos that have substantially fewer neurons and excess glia(Jones, et.al, 1995; Hosoya, et.al, 1995; and Vincent, et.al, 1996). Additionally, gcm has also been shown to be involved in the differentiation of blood …

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Effect Of Sulfobutyl Ether Β-Cyclodextrins On Oral And Dermal Pharmacokinetics Of Drugs, Vijay Kumar Shankar Jan 2019

Effect Of Sulfobutyl Ether Β-Cyclodextrins On Oral And Dermal Pharmacokinetics Of Drugs, Vijay Kumar Shankar

Electronic Theses and Dissertations

Silymarin is an extract of Milk Thistle, major constituents are taxifolin, silychristin, silydianin, silybin A, silybin B, isosilybin A and isosilybin B. The in vitro, preclinical and clinical studies have demonstrated silymarin possesses hepatoprotective, anticancer, hypocholesterolemic, cardioprotective effect and dermatological beneficial effect (treatment of UV induced erythema, melanoma, non-melanoma skin cancer, rosacea, melasma, vitiligo and psoriasis) both individually and collectively. Solubility enhancement of silymarin constituent is utmost important to increase bioavailability and to improve drug developability property. The solubility of silymarin in water was enhanced by SBE-β-CD by conventional and heating method, heating method was found to be more efficient …

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The Role Of Dunc13 In Ethanol Tolerance, Yusuke Wachi Jan 2019

The Role Of Dunc13 In Ethanol Tolerance, Yusuke Wachi

Electronic Theses and Dissertations

Although the effects of ethanol on presynaptic activity have been studied, the molecular mechanisms and the changes in gene expression which are responsible for inducing ethanol tolerance are unclear. Munc13-1 is an active-zone protein that is essential for presynaptic vesicle fusion. This protein interacts with vesicle fusion machinery at presynaptic active zones in the mammalian brain. The C1 domain of Munc13-1 binds diacylglycerol (DAG), which helps membrane localization of this protein and promotes vesicle fusion, facilitating synaptic vesicle release. Previously, it was shown that ethanol binds to the C1 domain of Munc13-1 in vitro at concentrations below 100 mM (Das …

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Developing Zebrafish As An In Vivo Model To Screen Compounds For Anti-Cancer Activity In Human Breast Cancer, Trisha Dhawan Jan 2019

Developing Zebrafish As An In Vivo Model To Screen Compounds For Anti-Cancer Activity In Human Breast Cancer, Trisha Dhawan

Electronic Theses and Dissertations

Breast Cancer (BC) is the most frequently diagnosed cancer; 1:8 women are at risk of developing BC in her lifetime. Cancer metastasis causes the majority of deaths in BC patients. Moreover, side effects of traditional chemotherapeutic drugs (TCD) impair the quality of life of these patients. Discovery and development of safe and effective new therapies is imperative for the treatment of BC and targeting metastasis. The goal herein is to further expand the applicability of in vivo xenotransplantation of human BC cells in transgenic zebrafish to screen potential chemotherapeutics for toxicity and efficacy. For xenotransplantation, MCF-7, BT-474, and MDA-MB-231 BC …

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Effect Of Solvent Interaction & Soluble Microneedles On Skin Permeability To Drug Molecules, Abhijeet Maurya Jan 2019

Effect Of Solvent Interaction & Soluble Microneedles On Skin Permeability To Drug Molecules, Abhijeet Maurya

Electronic Theses and Dissertations

Skin forms a formidable barrier protecting the human body from external environmental rigors and excessive loss of water; maintaining equilibrium. The barrier properties of the skin can be attributed to its unique macromolecular organization and morphology. As a route for drug administration, skin presents a large surface area and can be used for both systemic and localized targeted drug delivery applications offering several advantages over conventional drug therapy; avoidance of first pass metabolism, patient compliance, sustained or controlled delivery for an extended period, to name a few. However, the organized structure of the skin, since intended to prevent entry of …

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Novel Applications Of Hot-Melt Extrusion Technology In Trans-Buccal And Topical Drug Delivery Systems, Nicole Mendonsa Jan 2019

Novel Applications Of Hot-Melt Extrusion Technology In Trans-Buccal And Topical Drug Delivery Systems, Nicole Mendonsa

Electronic Theses and Dissertations

As the buccal route of administration can avoid the first pass effect, the bioavailability of drugs that are metabolized in the liver can be increased through this route. Few studies have been conducted using oleic acid as a permeation enhancer in any trans-buccal dosage form. The objective of this study was to develop a buccal tablet using two concentrations of oleic acid for a model drug (Ondansetron) via melt extrusion technology and investigate the effects of oleic acid on the physicochemical properties of the tablet. Formulations consisting of the active drug (ondansetron hydrochloride), polymers and oleic acid were prepared by …

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Explication Of Moral Disgust: Assessing Physiological And Behavioral Responses To Disgust Eliciting Videos, Sarah Michelle Scott Jan 2019

Explication Of Moral Disgust: Assessing Physiological And Behavioral Responses To Disgust Eliciting Videos, Sarah Michelle Scott

Electronic Theses and Dissertations

Results indicate a significant self-reported disgust response among core animal reminder and contamination domains whereas the moral domains elicited both anger and disgust. Physiologically no change was measured in skin conductance; heart rate decrease in response to animal reminder contamination community and autonomy video clips. Significant behavioral avoidance was demonstrated when presented with the core and animal reminder video clips. Further when measuring facial muscle activation the levator labii was significantly activated in response to the core video clip but no others. The current study highlights the difficulty in establishing characteristic responses to disgust stimuli especially within the moral domain. …

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Going To Bat: Assessing Disgust Sensitivity And Related Factors In Behavioral Avoidance, Molly E. Wickenhauser Jan 2019

Going To Bat: Assessing Disgust Sensitivity And Related Factors In Behavioral Avoidance, Molly E. Wickenhauser

Electronic Theses and Dissertations

The present study used archival data (N = 194) consisting of responses from a battery of questionnaires and data from eight behavioral avoidance tasks (BATs). Correlational analyses demonstrated that disgust sensitivity, anxiety sensitivity, state disgust and anxiety ratings during BATs, and behavioral avoidance on BATs were significantly correlated. Higher disgust sensitivity and behavioral avoidance was also associated with being female. Unexpectedly, emotion dysregulation was not correlated with disgust sensitivity or behavioral avoidance. Next, a series of hierarchical multiple linear regressions indicated that the contamination disgust domain appeared to be the strongest predictor of behavioral avoidance on core- and contamination-related BATs, …

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Effects Of Impoundments On The Community Assemblage And Gene Flow Of Stream Crayfishes, Zanethia Choice Barnett Jan 2019

Effects Of Impoundments On The Community Assemblage And Gene Flow Of Stream Crayfishes, Zanethia Choice Barnett

Electronic Theses and Dissertations

Dams and their impoundments block movement of stream organism and change stream physiochemical properties, which subsequently changes biological assemblages and creates barriers to gene flow. While changes in species assemblages and gene flow have been assessed for numerous impoundments and stream organisms, no study has assessed the effects of large impoundments on crayfish assemblages and population genetic diversity and connectivity. I examined the physiochemical, biological, and genetic effects of impoundments on crayfishes. Between May 2015 and August 2017, I sampled multiple sites up- and downstream of three impounded streams, and along the lengths of two unimpounded streams, in the Bear …

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A Descriptive Study Of The Faber Series Piano Adventures And Its Implications For Piano Pedagogy, Martha Frances Monroe Jan 2019

A Descriptive Study Of The Faber Series Piano Adventures And Its Implications For Piano Pedagogy, Martha Frances Monroe

Electronic Theses and Dissertations

The purpose of this study is to examine the Piano Adventures method books written by Randall and Nancy Faber. The series was thoroughly researched and developed for ten years before it was published in 1993. Since that time, the series has been enhanced and has added numerous additional books of repertoire, technique, and improvisation. An online application has been created to help not only students, but also to provide teaching tools and guides for teachers. With the inclusion of technology at the forefront of all education, the Faber series has opened the door for students through a new approach that …

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Phytochemical Investigation And Drug Interaction Potential Of Cyanotis Vaga, Ibrahim Almarabi Jan 2019

Phytochemical Investigation And Drug Interaction Potential Of Cyanotis Vaga, Ibrahim Almarabi

Electronic Theses and Dissertations

Cyanotis. vaga (Lour.) Schult, & Schult. f. (C. vaga) previously called Tradescantia vaga and Cyanotis barbata, is a perennial herb. It is native to Eastern Asia and Tropical Africa. It has been reported that its decoction reduces fever and enhances well-being. Recently, C. vaga has been used widely for its anabolic effects, due to its richness of ecdysteroids. Even though C. vaga is a commedicinal plant (dietary supplement), there are no reports about its effect on the drug metabolizing enzyme Cytochromes P450 to predict its interaction with concomitantly used medications. In this study, eight ecdysteroids were isolated …

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The Independent And Combined Effects Of Hypoxia And Tributyltin On The Eastern Oyster, Crassostrea Virginica, Ann Fairly Barnett Jan 2019

The Independent And Combined Effects Of Hypoxia And Tributyltin On The Eastern Oyster, Crassostrea Virginica, Ann Fairly Barnett

Electronic Theses and Dissertations

Oysters are vital to the health of estuarine ecosystems and provide critical ecosystem services, such as water quality improvement, nursery habitat for commercially important fisheries, and shoreline stabilization. Despite their ecological and economic importance, oyster reefs are exposed to many stressors, and oyster populations in Mississippi have declined dramatically in recent years. The present study focuses on the effects of hypoxia and tributyltin (TBT) on the Eastern oyster, Crassostrea virginica. Hypoxic events are increasingly comin coastal ecosystems worldwide, and TBT is a legacy toxicant once used as an antifoulant. The effects of these stressors were assessed on adult oysters deployed …

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The Evolution Of Coral Snake Mimicry, Renan Janke Bosque Jan 2019

The Evolution Of Coral Snake Mimicry, Renan Janke Bosque

Electronic Theses and Dissertations

Scientists have regarded mimicry as one of the most amazing examples of the power of natural selection. Early observations by naturalists of the mimetic association between venomous New World coral snakes of the genus Micrurus and harmless mimics has stimulated an intense debate about the causes and consequences of mimicry that persists today. Despite its medical, evolutionary and historical importance our understanding of evolution within the genus Micrurus is negligible. My dissertation explores the evolution of mimicry within South American coral snakes and their mimics using a multi-scale framework involving macroevolutionary (Chapter I), geographic/morphological concordance (Chapters II and III), behavioral …

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Twin Text In The Secondary Social Studies And English Classroom, Sarah Booth Quong Jan 2019

Twin Text In The Secondary Social Studies And English Classroom, Sarah Booth Quong

Electronic Theses and Dissertations

This mixed-method study explores the implementation of Twin Text and its effectiveness in the U.S. History and English classrooms with regard to: mastery of the objectives laid out within the course curriculum, perpetuation of deeper learning, and fostering empathy and civic engagement through the use of Twin Text involving tenth and eleventh grade students and United States History and English teachers. The study answers the following questions: (1) What are the experiences of students in a Twin Text setting classroom environment? Three sub questions emerged: (A) In what ways does cross-curriculum teaching with an English Language Arts instructor affect student …

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Extended Adolescence: The Ecology And Endocrinology Of Facultative Paedomorphosis, Jason R. Bohenek Jan 2019

Extended Adolescence: The Ecology And Endocrinology Of Facultative Paedomorphosis, Jason R. Bohenek

Electronic Theses and Dissertations

Phenotypic plasticity is an adaptation to unpredictable environments whereby an organism of a single genotype may express more than one phenotype under differing environmental conditions. Phenotypic plasticity can manifest as polyphenisms, which is an extreme form of phenotypic plasticity that produces two or more discrete, alternative phenotypes. The expression of alternative phenotypes is controlled by biotic and abiotic environmental factors, which variably affect the strength and direction of phenotypic outcomes. Using a model polyphenic salamander, I sought to understand the ecological and hormonal processes that regulate alternative phenotype expression. The mole salamander (Ambystoma talpoideum) and eastern newt ( …

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Allodynia And Self-Efficacy In Migraineurs, Ashley N. Polk Jan 2019

Allodynia And Self-Efficacy In Migraineurs, Ashley N. Polk

Electronic Theses and Dissertations

Headache disorders are among the most comdisorders of the nervous system, with migraine alone affecting 14% of women and 6% of men worldwide each year. Headache-related self-efficacy, or one’s confidence in preventing and managing headache, is particularly important for prevention and management of headache disorders and predicts response to behavioral and pharmacological treatments. Allodynia, the perception of non-noxious stimuli as painful due to central sensitization, compounds headache-related disability and compromises efficacy of triptans. Therefore, migraineurs with allodynia may perceive headache treatments as less efficacious and thus have reduced perceived headache-related self-efficacy. However, no literature to date has explored the relationship …

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Patient Empowerment In Modern Medicine: A Personal Account Of Endometriosis And Being An Equal Partner In My Healthcare, Jacqueline Schlick Jan 2019

Patient Empowerment In Modern Medicine: A Personal Account Of Endometriosis And Being An Equal Partner In My Healthcare, Jacqueline Schlick

Electronic Theses and Dissertations

This work outlines my personal experience with a diagnosis of stage three endometriosis and partial oophorectomy surgery along with the subsequent medical opinions I received by my primary OB/GYN and other doctors. This thesis seeks to discuss the issues surrounding patient empowerment, and specifically, laws that support patients in their exploration of the truths behind their conditions and the importance of self-education in order to be better equipped in conversations with their physicians. The work includes testimonials from women about their levels of knowledge into their own medical needs upon the time of their prescription to pharmaceutical medications, and how …

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Variations In The Dragonfly Microbiome Through Life Stages And Its Ability To Harbor Antibiotic Resistant Bacteria, Sarah Russell Jan 2019

Variations In The Dragonfly Microbiome Through Life Stages And Its Ability To Harbor Antibiotic Resistant Bacteria, Sarah Russell

Electronic Theses and Dissertations

Juvenile dragonflies (nymphs) may possess the ability to pass their microbiome to the adult life stage through metamorphosis. If this is so, the environment in which the nymph develops may have an effect on the adult microbiome. In this study, the gut microbiomes of 13 species of dragonfly were compared across life stages and when collected from environments at different levels of urbanization. The gut of each dragonfly was removed, DNA extracted, and a portion of the bacterial 16S rRNA gene amplified and sequenced. Gut suspensions were also plated on antibiotic amended plates to determine the potential for dragonflies to …

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Minimum Number Of Individuals: A Methodological Comparison Using Human Remains From Caves Branch Rockshelter In The Cayo District Of Belize, Caitlin Elizabeth Stewart Jan 2019

Minimum Number Of Individuals: A Methodological Comparison Using Human Remains From Caves Branch Rockshelter In The Cayo District Of Belize, Caitlin Elizabeth Stewart

Electronic Theses and Dissertations

The analysis of human remains in archaeological contexts is often complicated by the presence of highly fragmented and commingled remains. The standard methods used to help quantify the number of individuals and elements in these contexts are based upon the segmentation of whole bones. The methods provide standardization and are flexible enough to allow for the idiosyncratic nature of each context. However, this results in a lack of transparency, which is necessary to reanalyze the same sample or to compare “like” contexts, as the data collected will vary.

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Formulation Development, Preclinical Testing, And Primary Packaging Optimization For Cannabinoids And Other Therapeutics, Pranjal Taskar Jan 2019

Formulation Development, Preclinical Testing, And Primary Packaging Optimization For Cannabinoids And Other Therapeutics, Pranjal Taskar

Electronic Theses and Dissertations

Through the process of drug development, a molecule goes through discovery screening; lead selection and optimization, ADME testing, toxicity profiling, dosage form determination, preclinical testing in an in vitro and in vivo setup, folloby clinical research, FDA review and approval until eventually it is manufactured in the determined dosage form and reaches the patient. At every point through this process, scientists actively work towards a smoother transition and a quick and safe approval of the molecule towards the next step. The different chapters in this research would cover various phases of drug development; from discovery stage to fill-finish and primary …

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Bacterioplankton Biogeography Of The Mississippi River Basin, Jason Taylor Payne Jan 2019

Bacterioplankton Biogeography Of The Mississippi River Basin, Jason Taylor Payne

Electronic Theses and Dissertations

Bacterioplankton are important structural and functional components of river networks yet their biogeographical patterns in these systems are largely unknown. Using Illumina sequencing of the 16S rRNA gene we characterized variation in bacterioplankton community alpha diversity (within-sample richness of operational taxonomic units OTUs) and beta diversity (between-sample differences in composition) (1) along a 1 300-km downstream reach of the Mississippi River (2) over a range of temporal scales in the Lower Mississippi River (LMR) and (3) along cross-sectional transects repeated monthly for six months across the LMR floodplain. Particle-associated assemblages were richer in bacterial OTUs and more productive than free-living …

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