Digital Commons Network^™

Beat The Church Crowd, Evelyn Alston Tyer

Honors Theses

Beat the Church Crowd is a collection of poems that explores a variety of topics and themes, from personal family legacy and natural disasters to bestiary, ekphrastic, and southern locale poems. It is divided into four sections: “Blue Danube,” “Anecdotes,” “Urban Legends,” and “Something Worth Protecting.” While the subject matter and forms of the poems vary, the common thread weaving each poem to the next is the slight touch of the macabre.

Little Girl In The Country: A Children's Book, Holly Mcginnis

Honors Theses

A Work of Children’s Literature to Address Realities of Childhood in the Southern United States

This thesis investigated the intersection of life’s realities and children’s literature. Representation is an oft-talked-about area of children’s literature. It is coming to light that many groups are underrepresented in writings for children, and recent works are attempting to broaden the types and backgrounds of characters to represent the diversity of readers and authors. This thesis is the author’s attempt to accurately represent the types of students she encountered in student teaching experiences in the Oxford-area. Using inspiration from her own childhood and knowledge of …

Lead In Drinking Water And The Effectiveness Of Point-Of-Use Filtration, Donald Hopper

Honors Theses

Lead in drinking water has been proven harmful to human health and is an ongoing problem in the state of Mississippi. The goal of this thesis is to analyze lead contamination data in Mississippi, its implications, and possible short-term solutions for remediation. This was done through community outreach events and voluntary sampling in the Jackson, MS area, analyzing published data from the Mississippi State Department of Health, and conducting controlled sampling and testing in Lafayette County, MS.

Community engagement events were executed in which researchers informed citizens in the Jackson, MS area about the impacts of lead in drinking water …

More Than A Language: A Detailed Look At The English Major, Hannah Woods

Honors Theses

This thesis analyzes the perceptions of the English Major in order to come up with suggestions for the Univeristy of Mississippi English Department with the purpose of increasing enrollment in the English Program. The last decade has seen a large decrease in the number of English Majors throughout the country, and this decrease has been reflected in the University of Mississippi. This thesis looks at recent opinions of the English Major in society, including popular criticisms of the major and responces from the English community. It was found that the two main criticisms of the English Major are that graduates …

The Effects Of Insulin-Like Growth Factor-1 (Igf-1) And Insulin-Like Growth Factor Receptor (Igfr) Regulation On Cognition And Structure Of Astrocytes, Sariya Khan

Honors Theses

Insulin-like growth factor-1 (IGF-1) is a neuroendocrine signaling hormone that plays an integral role in bone and tissue growth and development. Inhibition of this hormone is known to disrupt the chemistry of the brain, resulting in cognitive impairments such as those seen in many common neurodegenerative diseases. While much research has been conducted on neurons and their relation with IGF-1, the role of astrocytes still needs to be explored. Our research investigates how astrocytes are affected as a result of IGF-1 regulation. Preliminary studies in our laboratory established a connection between IGF-1 and glial fibrillary acidic protein (GFAP), and in …

Electronic Health Records And Health Information Exchange And Their Impact On International Healthcare System Efficiency, David Pfaehler

Honors Theses

The 19th century epidemiological transition in healthcare caused a major shift in physician focus from curing one-time, deadly illness to managing chronic disease. Now, even the most advanced international healthcare systems must find a way to increase their efficiency in order to compensate for heightened strains on medical systems and swelling costs of healthcare delivery. Fortunately, recent technological innovation and, chiefly, the growth of Electronic Health Records (EHRs) provide a potential solution to this looming threat. EHRs are digital charts with the potential to store and share patient health data among providers to offer the most informed, streamlined care available. …

Facebook: A Contemporary Analysis Of The Influential Global Power Of Facebook And How It Affects Our Society (And Recommendations On How To Fix It), Jayde Taylor

Honors Theses

This thesis analyzes the global influence of the major social media platform Facebook, in real time. The text reviews Facebook’s guidelines and regulations and provides examples of significant social influence. It also analyzes possible solutions, why these solutions provide barriers, and recommendations for current Facebook users.

This information was collected by the individual during months of research. It started with a broader focus on the spread of false information and media literacy. After getting an in-depth understanding, it was decided to focus more specifically on Facebook. All information was collected from scholarly journals, news articles, books, and Facebook. The research …

A Nonanthropocentric Response To The Cosmic Perspective Problem, Eveanne Eason

Honors Theses

This paper responds to issues that have been raised for environmental philosophy in light of developments in astrobiology and exoplanet science. In recent years, we have moved much closer to confronting evidence of life beyond Earth. Pairing such a discovery with a certain theoretical understanding of the universe, we might be motivated to address a question: with knowledge of abundant, potentially infinite alien life on Earth-like planets, why must we save our planet? In anticipation of this discovery, we can use this scenario, the Cosmic Perspective Problem, to refine a widely-held position with substantial implications for our environmental ethics. The …

Studies Of Salvinorin-Based Antagonists To Elucidate Pertinent Interactions For Kappa Opioid Receptor Antagonism, Madeline Keane

Honors Theses

Opioid abuse, leading to addiction and related deaths, has created a chronic epidemic in the United States for the past 30 years. This crisis has sprung from reliance on the prescription of opioid analgesics as the primary method for the management of pain in the 1990s. At that time, these drugs, specifically Purdue Pharma’s OxyContin, were marketed as non-addictive. Due to this systemic minimization of the addictive properties of opioid analgesics, as prescription rates increased, opioid-related mortality rates climbed. This epidemic continues to be pervasive, as opioid-related overdose resulted in 47,600 deaths in 2017. In addition to the opioid epidemic, …

Elucidating The Functional Location Of Platelet-Derived Growth Factor Receptor Alpha, Creation Of A Review Chapter On The Use Of Zebrafish In Studying Congenital Heart Defects, And Using 3d Printing To Create Laboratory Tools, Jaret Lieberth

Honors Theses

Congenital heart defects (CHDs) are currently the most prevalent form of birth defect in the United States. Their combined frequency and severity make necessary a deeper understanding of the molecular underpinnings guiding heart formation. The first major step in cardiac morphogenesis, cardiac fusion, involves the medial movement of bilateral populations of myocardial precursor cells to the embryonic midline, where they merge to form the primitive heart tube. Although crucial to subsequent organogenesis, the precise mechanisms governing cardiac fusion remain unknown. Previous studies have found that a mutation in platelet-derived growth factor receptor alpha (pdgfra), called refuse-to-fuse (ref), results …

A Raman Spectroscopic And Quantum Chemical Investigation Of Serotonin, It's Intramolecular Interactions, And The Solvent Effects Of Methanol, Ethanol, And Water, Mallory Loe

Honors Theses

Serotonin, or 5-hydroxytryptamine, is a neurotransmitter and metabolite vital to the normal function of the cardiovascular, gastrointestinal, and nervous systems. Although it might be colloquially known as the ‘happiness drug,’ malfunctions in serotoninergic pathways can result in mental health disorders, heart disease, irritable bowel syndrome, and even collateral death. Without a current method to directly measure, or even detect, serotonin in the human body, these diseases, along with many others, pose a threat of developing without proper warning. Raman spectroscopy presents a unique method to vibrationally characterize molecules based upon the inelastic scattering of light. Serotonin’s unique, amphipathic structure presents …

Ectomycorrhizal Fungi And Effects Of Soil Microbes Associated With Slash Pine Encroachment Into Native Longleaf Pine Habitat, Madison Brooke Woodruff

Honors Theses

Biological invasions can cause substantial changes to the environment: indigenous species can be reduced or even eliminated, soil characteristics shifted, and nutrient cycles altered. Ectomycorrhizal (ECM) fungi are thought to be key biological controllers of some plant invasions, especially benefiting Pinus species in invasions at exotic sites, but less is understood about the role of ECM fungi and other soil microbes in encroachment by one plant species into the habitat of another in their native ranges. In this study, soil was collected from three habitats in southern Mississippi, USA: native slash pine maritime forest, longleaf pine savanna encroached by slash …

Impacts Of Embryonic Exposure To Cannabidiol Or ∆9-Tetrahydrocannabinol On Zebrafish (Danio Rerio) Frailty In F0 And F1 Generations, Anika Faruque

Honors Theses

Exposure to cannabinoids during critical development periods has increased with epileptic children being commonly prescribed CBD for seizures and pregnant women taking it recreationally. Many studies have been done on the possible benefits and drawbacks of cannabinoid exposure on the human brain, but not much is known about how it can affect the developing brain long-term. To see the potential adverse effects of cannabinoid exposure during critical stages of development and discover potential developmental origins of disease in consuming cannabinoids during embryogenesis, zebrafish embryos (6-96 hours post fertilization) were exposed to varying concentrations of CBD (0.02, 0.1, 0.5 µM), THC …

Exploring The Role Of Ccdc141 In Zebrafish Heart Development, Luci Strong

Honors Theses

Zebrafish are a good model organism in which to identify genes important for heart development because most human genes have a zebrafish ortholog and genes in zebrafish are relatively simple to modify. ccdc141 is a gene with unknown function, which we originally found to be highly expressed in cardiac cells in mouse embryos. In this project, we are seeking to determine the function of ccdc141 using zebrafish. To perform this experiment, we are targeting ccdc141 for mutation using CRISPR/Cas9. In this project we have analyzed ccdc141 to determine regions of conservation, designed CRISPR guides to target those regions (exon 2 …

The Life And Struggles Of Red Cockaded Woodpeckers, Michaela Gay

Honors Theses

This series of paintings focuses on red cockaded woodpeckers, an endangered species of bird and the longleaf pines forests which they live in and are reliant upon. I drew my inspiration mostly from personal experience with my family’s own efforts to restore one of these forests as well as my longstanding belief in the importance of protecting the environment. However, the point of these paintings is not to preach to people, but rather to show them the beauty of these trees and birds, so they can perhaps begin to care about them themselves instead of just being told that they …

Effects Of Repeated Intermittent Episodes Of Social Stress On The Acquisition And Extinction Of A Reward-Seeking Task, Nikki Sullivan

Honors Theses

Repeated exposure to stress is known to have a myriad of effects on the brain, contributing to the development of psychiatric disorders, such as anxiety, depression, and drug addiction. For example, rats undergoing repeated social stress develop increased cocaine self-administration. These effects of stress are not well-understood and are related to changes in the brain reward system. This study investigated the effects of repeated social stress on reward-seeking behavior via the acquisition and extinction of a discriminative stimulus (DS) task and on anxiety-like behavior in the elevated plus maze (EPM). Male rats underwent intermittent social defeat (4 sessions in 10 …

The Impact Of Age/Rage Signaling On Oxidative Stress Under Diabetic Conditions In Cardiac Fibroblasts, Christopher Dorroh

Honors Theses

Diabetes is a major health concern in the United States, with 1.5 million new cases diagnosed each year. Patients who suffer from diabetes have an increased risk of developing heart failure, a form of cardiovascular disease. Heart failure has been shown to result from increased left ventricular stiffness, which in turn is caused by increased remodeling of the extracellular matrix (ECM). This increase in ECM remodeling is a result of AGE/RAGE signaling, which occurs at a heightened level in the cardiac fibroblast cells of diabetics. Studies have shown that diabetics have elevated levels of AGEs (Advanced Glycation End-Products), which bind …

The Marduk Archives: A Take On Thresholds, Christopher Melton

Honors Theses

A fictional screenplay exploring the relationship between absurdity and convention as it pertains to the shifting cultural paradigms of our society. (Under the direction of Beth Spencer)

Implementation Of A Computer-Vision System As A Supportive Diagnostic Tool For Parkinson’S Disease, Diego Machado Reyes

Honors Theses

Parkinson’s disease is the second most common neurodegenerative disorder, affecting nearly 1 million people in the US and it is predicted that the number will keep increasing. Parkinson’s disease is difficult to diagnose due to its similarity with other diseases that share the parkinsonian symptoms and the subjectivity of its assessment, thus increasing the probabilities of misdiagnosis. Therefore, it is relevant to develop diagnostic tools that are quantitatively based and monitoring tools to improve the patient’s quality of life. Computer-based assessment systems have shown to be successful in this field through diverse approaches that can be classified into two main …

Etruscan Biophilia Viewed Through Magical Amber, Greta Rose Koshenina

Honors Theses

In this thesis, I explore the usage and purpose of amber objects in burials from Etruria, specifically from the late Villanovan Period (ca. 800-720 BCE) to the Orientalizing Period (ca. 720-580 BCE). I have followed a combination of quantitative and qualitative research approaches as well as visual analysis of amber grave goods. While there has been extensive research on the medicinal and ritual purposes of amber grave goods from excavated Etruscan tombs, I show that there was likely a specific interest in amber that contains organic inclusions likely because of the Etruscans’ interest in nature. I examine the presence and …

Receptive And Expressive Prosodic Abilities In Adults With Down Syndrome, Logan A. Kingry

Honors Theses

Individuals with Down syndrome, a population that often struggles with communication, present a unique linguistic profile of strengths and weaknesses. Almost no research has examined prosody in adults with DS, despite the important role it plays in effective communication. The present study investigated the prosodic profile of seven adults with Down syndrome (18;07-34;11 years) using the Profiling Elements of Prosody for Speech and Communication (PEPS-C), and compared the group’s expressive and receptive prosodic abilities to a group of seven adults with mixed-etiology intellectual and developmental disability (29;02-37;07 years) matched on nonverbal ability. Data analyses showed that the group with Down …

Pecking The Hands That Feed Them: How Society And Government Have Allowed The Poultry Industry To Exploit Labor And The Environment In The American South, Sophie M. Kline

Honors Theses

Americans eat an average of ninety pounds of chicken in one year, but where does that chicken come from? Immigrants and African Americans are the majority of the labor population in poultry processing plants located in the American South. In an effort to highlight the racism, sexism, insecurity, and environmental degradation in the poultry industry, I analyze a variety of ethnographies, articles, and science journals as well as U.S Supreme Court decisions and policies enacted by the U.S federal government in this thesis. Upon examination, I answer why society is pecking the hands that feed them. The analysis concludes that …

In-Vitro Assessment Of Cb1/Cb2 Receptor Binding And Function, Joey M. Davis

Honors Theses

Cannabinoid receptors CB1 and CB2 are G protein-coupled receptors that have a variety of physiological effects on the human body. Many natural product agonists and antagonists are presumed to interact with the cannabinoid receptors and are therefore heavily studied in drug discovery. Assays are used to study the binding of compounds to these receptors. However, a limited number of these assays are efficient in determining the functional activity of ligands associated with CB1 and CB2. Of those, many use radioactivity which is both expensive and potentially dangerous to the researcher. In this study, we first validated the assays already found …

An Outside Gaze On The Relationship Between Indigenous Groups And The Media, Nicole Daoust

Honors Theses

Indigenous groups around the world faced similar challenges. Many of these issues stem from stereotypes, one-sided stories, and overall lack of representation in the media. Without a voice or ally, they are often treated as second class citizens. For my research, I analyzed how the media affected public perception of indigenous people. I specifically focus on four groups: The Aboriginals of Canada, the Māori, Native Americans, and the uncontacted tribes of the Amazon.

Parks And People: Connection To Nature And Wellbeing Among U.S. National Park Seasonal Workers, Maureen Maher

Honors Theses

In the midst of our evolving world, cultivating positive and reciprocal relations between humans and the natural world is essential for our wellbeing and our future. This study on national park seasonal workers (n = 203) was designed using mixed methods to further our understanding of the overlapping relationships humans and communities share with nature and the effects these have with our overall wellbeing. We hypothesized that nature contact, nature connection, sense of community, and intrinsic motivation would predict overall wellbeing, as defined by satisfaction with life, harmony in life, civic action, and diversity attitudes. Each outcome was examined separately …

Study Of Pharmaceutical Tablets Using Raman Mapping, Kyle Joseph Pauly

Honors Theses

Covalent bonds are the strongest type of bonds holding molecules together. Based on the pattern of bonding of the molecule, the atoms associated with the bond will vibrate at a specific frequency. Utilizing vibrational spectroscopy, such as Raman spectroscopy, these unique vibrational frequencies can be used to detect the presence of analytes over a selected area. Furthermore, the intensities of the vibrational modes can be tracked to comparatively quantify the concentration of analytes at various locations. This is a method of great importance due to its ability to compare pharmaceutical tablets synthesized with different techniques. Here, the presence and concentration …

Sunset Piracy: The Ends Of Atlantic Piratical Careers In The Age Of Sail, Cory Henderson

Honors Theses

This thesis concerns the careers of pirates in the latest stage of that career, as pirates prepared to end their roving of the seas in order to “settle down.” Though pirates are idolized in modern fiction, their ends are often overshadowed by the highlights of their careers. Here, the goal is to find what motivated pirates to engage in a life as outlaws and then at some point choose to cast that life aside. Conclusions on this are drawn from both primary and secondary sources where pirates gave information pertaining to their view of the world and retirement in it, …

Religion In George R.R. Martin's "A Song Of Ice And Fire" Franchise, Sydney A. Craven

Honors Theses

This thesis is a study of religion in George R.R. Martin's A Song of Ice and Fire franchise. Specifically, George R.R. Martin's use of medievalisms, his interpretation of the Middle Ages, when creating the religions in A Song of Ice and Fire.

Use Of Embark Database And An Active Learning Protocol In A High School Classroom, Landon Goodreau

Honors Theses

With advances in technology, personal genome sequencing has become more affordable than ever before. With this wealth of genetic information come new individualized approaches to medicine and pharmacology, along with moral, legal, and ethical issues to carefully consider. Yet studies suggest that most members of the general public do not have the genetic literacy required to understand the implications of genomic data. It is important that today’s students are able to grasp concepts relating to their own genome to make informed medical decisions in the future. Here I describe an active learning-based activity designed to enhance high school students’ understanding …

Characterization Of A Plasmid-Based Dna Vaccine For Simian Immunodeficiency Virus, Priya Sanipara

Honors Theses

Described as one of the world’s worst pandemics, HIV (Human Immunodeficiency Virus) infects millions of people each year and is the cause for AIDS (Acquired Immunodeficiency Syndrome). Despite the development of vaccines for numerous infectious diseases such as polio, small pox, and influenza, a vaccine for HIV remains elusive due to the virus’s high mutation rate and ability to evade the immune system. HIV causes depletion of CD4+ lymphocytes, resulting in a weakened immune system. However, the development of a plasmid-based DNA vaccine approach may help revolutionize vaccine development for HIV due to its ability to confer cellular and humoral …