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Renin-Angiotensin-Aldosterone System In Preeclampsia: Pathophysiological Insights And Links To Vascular Dementia, Robin C. Finch, Jenny Lutshumba, Elizabeth Mirsky, Esther Ndashaala, Kelsey Bullens, Emma Smith Feb 2026

Renin-Angiotensin-Aldosterone System In Preeclampsia: Pathophysiological Insights And Links To Vascular Dementia, Robin C. Finch, Jenny Lutshumba, Elizabeth Mirsky, Esther Ndashaala, Kelsey Bullens, Emma Smith

Pediatrics Faculty Publications

Pre-eclampsia, a condition characterized by new-onset hypertension during pregnancy and one or more indices of organ damage, is a major driver of both short and long-term maternal health outcomes. Individuals with a history of pre-eclampsia are at increased risk for cardiovascular, renal, and other chronic diseases. Recent studies have linked pre-eclampsia history with increased risk of dementia later in life, underscoring the importance of new guidelines emphasizing blood pressure control to reduce the risk of cognitive decline. Unfortunately, neither mechanisms underlying causes of pre-eclampsia nor their links with cognitive function are well understood. Vascular contributions to cognitive impairment and dementia …

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Mauve, Luca Cortese, Adam Brian Watts, Jiayi Sun, Sriram Sankar, Barbara Catinella, Toby Brown, Alessandro Boselli, Pavel Jáchym, Tutku Kolcu, Sabine Thater, Jesse Van De Sande, Vicente Villanueva Feb 2026

Mauve, Luca Cortese, Adam Brian Watts, Jiayi Sun, Sriram Sankar, Barbara Catinella, Toby Brown, Alessandro Boselli, Pavel Jáchym, Tutku Kolcu, Sabine Thater, Jesse Van De Sande, Vicente Villanueva

Physics and Astronomy Faculty Publications

We present a multiphase study of the star-formation-driven outflow in the Virgo galaxy NGC 4383, combining ALMA CO(2-1) data with deep MeerKAT Hi imaging and MUSE spectroscopy obtained as part of the Multiphase Astrophysics to Unveil the Virgo Environment (MAUVE) program. Our previous work revealed a spectacular ionised outflow, but the effect of the outflow on the cold phase remained unclear. Our analysis shows that potentially outflowing molecular gas is detected only within the inner 1 kpc above the disc, where CO clouds exhibit disturbed kinematics and spatial correspondence with the ionisation cone. At larger heights, the CO surface brightness …

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Phase 1 Open-Label Study Of Asp9801, An Oncolytic Virus, In Patients With Advanced Or Metastatic Solid Tumors, John L. Villano, Jason J. Luke, Ricklie Julian, Christos Fountzilas, Manish R. Patel, Michael J. Chisamore, Pranob Bhattacharya, Shigeru Takeshita, Serguei Soukharev, Shunsuke Yamada, Leshi Zhang, Kristopher P. Wentzel Feb 2026

Phase 1 Open-Label Study Of Asp9801, An Oncolytic Virus, In Patients With Advanced Or Metastatic Solid Tumors, John L. Villano, Jason J. Luke, Ricklie Julian, Christos Fountzilas, Manish R. Patel, Michael J. Chisamore, Pranob Bhattacharya, Shigeru Takeshita, Serguei Soukharev, Shunsuke Yamada, Leshi Zhang, Kristopher P. Wentzel

Neurology Faculty Publications

Purpose ASP9801, an oncolytic virus encoding interleukin-7 and interleukin-12, was assessed for safety, tolerability, pharmacokinetics, and antitumor activity in patients with advanced solid tumors in a Phase 1 study. Methods The study comprised Part 1 ASP9801 monotherapy dose escalation and Part 2 dose expansion with ASP9801 monotherapy or plus pembrolizumab. Each part was divided into Groups A (ASP9801 injection into cutaneous/subcutaneous lesions) and B (ASP9801 injection into visceral lesions). Primary objectives were safety and maximum tolerated dose and/or recommended Phase 2 dose expansion (RP2D); secondary objectives included antitumor activity and pharmacokinetics. Results In dose escalation, 17 and 10 patients in …

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Spatial Control Of Myosin Regulatory Light Chain Phosphorylation Modulates Cardiac Thick Filament Mechanosensing, Caterina Squarci, Daniel Koch, Paul Anaya, Kenneth S. Campbell, Thomas Kampourakis Feb 2026

Spatial Control Of Myosin Regulatory Light Chain Phosphorylation Modulates Cardiac Thick Filament Mechanosensing, Caterina Squarci, Daniel Koch, Paul Anaya, Kenneth S. Campbell, Thomas Kampourakis

Physiology Faculty Publications

The heart can adapt its performance in response to changing metabolic demands of the rest of the body. A central mechanism intrinsic to the heart is to modulate the function of the cardiac contractile proteins via posttranslational modifications. Although phosphorylation of the cardiac myosin motor-associated regulatory light chain (RLC) by cardiac myosin light chain kinase (cMLCK) has been recognized as a key signaling pathway to increase myocardial contractile function, little is known about its molecular mechanism of action. Here, we show that phosphorylation of RLC is not a stochastic process but a spatially tightly controlled mechanism in the cardiac sarcomere. …

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Osimertinib Activates A Tgf-Β2-Dependent Secretory Program That Drives Lung Adenocarcinoma Progression, Madhurima Ghosh, Chao Wu, Abhishek Kumar, Monique Nilsson, John V. Heymach, Weina Zhao, Jiang Yu, Xin Liu, Na Ding, Shike Wang, Guan Yu Xiao, Angelo Chen, Kate Grimley, William K. Russell, Chad J. Creighton, Xiaochao Tan, Jonathan M. Kurie Feb 2026

Osimertinib Activates A Tgf-Β2-Dependent Secretory Program That Drives Lung Adenocarcinoma Progression, Madhurima Ghosh, Chao Wu, Abhishek Kumar, Monique Nilsson, John V. Heymach, Weina Zhao, Jiang Yu, Xin Liu, Na Ding, Shike Wang, Guan Yu Xiao, Angelo Chen, Kate Grimley, William K. Russell, Chad J. Creighton, Xiaochao Tan, Jonathan M. Kurie

Markey Cancer Center Faculty Publications

EGFR-mutant lung adenocarcinomas (LUADs) that are vulnerable to the EGFR antagonist osimertinib (Osi) eventually relapse, owing in part to the emergence of drug-tolerant persister (DTP) cells that arise through epigenetic mechanisms. Intratumoral DTP cells can herald a worse clinical outcome, but the way in which DTP cells influence LUAD progression remains unclear. Osi-resistant (OR) cells exhibit typical DTP cell features, including a propensity to undergo senescence and epithelial-mesenchymal transition (EMT), which can activate heightened secretory states. Therefore, we postulated that OR cells influence LUAD progression through paracrine mechanisms. To test this hypothesis, we utilized congenic pairs of EGFR-mutant LUAD cell …

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Fiscal Year 2023 Fhwa-536 Report For The Kentucky Transportation Cabinet, Doug Kreis, Candice Wallace, Bryan Gibson, Sarah Mccormack Feb 2026

Fiscal Year 2023 Fhwa-536 Report For The Kentucky Transportation Cabinet, Doug Kreis, Candice Wallace, Bryan Gibson, Sarah Mccormack

Kentucky Transportation Center Research Report

Every other year, the Federal Highway Administration (FHWA) requires that states submit a Local Highway Finance Report (FHWA-536) to the agency. This report summarizes data on local highway finances and is used by FHWA to evaluate relationships between and changes in revenues, expenditures and investment patterns, and financial trends. This report presents information submitted by Kentucky in its fiscal year (FY) 2023 FHWA-536. Total receipts from local, state, and federal sources used for road and street infrastructure equaled approximately $1.11 billion. Local sources of funding accounted for the largest share of total receipts (47%), followed by state government sources (45%), …

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Kytc Digital Project Delivery Phase 1 Summary, Rachel Catchings Feb 2026

Kytc Digital Project Delivery Phase 1 Summary, Rachel Catchings

Kentucky Transportation Center Research Report

The Kentucky Transportation Cabinet (KYTC) launched its Digital Project Delivery (DPD) Initiative in September 2020 with the goal of expanding the use of digitally formatted plan and project information throughout the transportation asset life cycle, from project delivery through asset management. KYTC retained Kentucky Transportation Center (KTC) staff with expertise in construction and design to facilitate DPD implementation. This document summarizes DPD-related efforts undertaken by the Cabinet over the past five years. Key activities completed during this period include a survey of Kentucky Association of Highway Contractors members to document their perspectives on design file usage and preferences, coordinating multiple …

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Resolvent Estimates In L∞ For The Stokes Operator In Nonsmooth Domains, Jun Geng, Zhongwei Shen Feb 2026

Resolvent Estimates In L∞ For The Stokes Operator In Nonsmooth Domains, Jun Geng, Zhongwei Shen

Mathematics Faculty Publications

We establish resolvent estimates in spaces of bounded solenoidal functions for the Stokes operator in a bounded domain Ω in Rd under the assumptions that Ω is C1 for d≥3 and Lipschitz for d=2. As a corollary, it follows that the Stokes operator generates a uniformly bounded analytic semigroup in the spaces of bounded solenoidal functions in Ω. The smoothness conditions on Ω are sharp. The case of exterior domains with nonsmooth boundaries is also studied. The key step in our proof involves new estimates that connect the pressure to the gradient of the velocity in the Lq average, but …

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Quasi-Optimal Cyclic Orbit Codes, Chiara Castello, Heide Gluesing-Luerssen, Olga Polverino, Ferdinando Zullo Feb 2026

Quasi-Optimal Cyclic Orbit Codes, Chiara Castello, Heide Gluesing-Luerssen, Olga Polverino, Ferdinando Zullo

Mathematics Faculty Publications

We focus on two aspects of cyclic orbit codes: invariants under equivalence and quasi-optimality. Regarding the first aspect, we establish a connection between the cyclic orbit code generated by a subspace U of Fqn and the associated linear set LU×U. Relating the size of the linear set to the number of fractions formed by the elements of U allows us to derive new bounds on the parameters of the cyclic orbit code. In the second part, we study a particular family of (quasi-)optimal cyclic orbit codes. With the aid of these codes we establish the existence of quasi-optimal codes in …

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Kentucky Cdl Adjudication Pilot And Compliance Needs Study, Jeeyen Koo, Andrew Martin, Jennifer Walton Feb 2026

Kentucky Cdl Adjudication Pilot And Compliance Needs Study, Jeeyen Koo, Andrew Martin, Jennifer Walton

Kentucky Transportation Center Research Report

This report examines trends in how Kentucky District Courts have adjudicated charges related to commercial driver’s license (CDL) and commercial motor vehicles (CMVs). Using court data, researchers evaluated historical patterns in charge filing volumes as well as conviction, dismissal, amendment, and diversion rates. Between 2002 and 2024, conviction rates declined and dismissals increased. Convictions peaked in the mid-70% range in the early 2000s, but fell to the mid-50% range by 2024. Speeding and other serious traffic violations — many of which are advanceable offenses — were dismissed or amended at rates that could have substantively affected the integrity of CDL …

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Fiscal Year 2024 Fhwa-536 Report For The Kentucky Transportation Cabinet, Doug Kreis, Candice Wallace, Bryan Gibson, Sarah Mccormack Feb 2026

Fiscal Year 2024 Fhwa-536 Report For The Kentucky Transportation Cabinet, Doug Kreis, Candice Wallace, Bryan Gibson, Sarah Mccormack

Kentucky Transportation Center Research Report

Every other year, the Federal Highway Administration (FHWA) requires that states submit a Local Highway Finance Report (FHWA-536) to the agency. This report summarizes data on local highway finances and is used by FHWA to evaluate relationships between and changes in revenues, expenditures and investment patterns, and financial trends. This report presents information submitted by Kentucky in its fiscal year (FY) 2024 FHWA-536. Total receipts from local, state, and federal sources used for road and street infrastructure equaled approximately $1.27 billion. Local sources of funding accounted for the largest share of total receipts (50%), followed by state government sources (41%), …

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Duration And Properties Of The Embedded Phase Of Star Formation In 37 Nearby Galaxies From Phangs-Jwst, Lise Ramambason, Mélanie Chevance, Jaeyeon Kim, Francesco Belfiore, J. M. Diederik Kruijssen, Andrea Romanelli, Amirnezam Amiri, Médéric Boquien, Ryan Chown, Daniel A. Dale, Simthembile Dlamini, Oleg V. Egorov, Ivan Gerasimov, Simon C.O. Glover, Kathryn Grasha, Hamid Hassani, Hwihyun Kim, Kathryn Kreckel, Hannah Koziol, Adam K. Leroy, José Eduardo Méndez-Delgado, Justus Neumann, Lukas Neumann, Hsi An Pan, Debosmita Pathak, Karin Sandstrom, Sumit K. Sarbadhicary, Eva Schinnerer, Jiayi Sun, Jessica Sutter, David A. Thilker, Leonardo Ubeda Feb 2026

Duration And Properties Of The Embedded Phase Of Star Formation In 37 Nearby Galaxies From Phangs-Jwst, Lise Ramambason, Mélanie Chevance, Jaeyeon Kim, Francesco Belfiore, J. M. Diederik Kruijssen, Andrea Romanelli, Amirnezam Amiri, Médéric Boquien, Ryan Chown, Daniel A. Dale, Simthembile Dlamini, Oleg V. Egorov, Ivan Gerasimov, Simon C.O. Glover, Kathryn Grasha, Hamid Hassani, Hwihyun Kim, Kathryn Kreckel, Hannah Koziol, Adam K. Leroy, José Eduardo Méndez-Delgado, Justus Neumann, Lukas Neumann, Hsi An Pan, Debosmita Pathak, Karin Sandstrom, Sumit K. Sarbadhicary, Eva Schinnerer, Jiayi Sun, Jessica Sutter, David A. Thilker, Leonardo Ubeda

Physics and Astronomy Faculty Publications

Light reprocessed by dust grains emitting in the infrared enables the study of the physics at play in dusty embedded regions, where ultraviolet and optical wavelengths are attenuated. Infrared telescopes such as JWST have made it possible to study the earliest feedback phases, when stars are shielded by cocoons of gas and dust. Comprehending this phase is crucial for unravelling the effects of feedback from young stars that leads to their emergence and the dispersal of their host molecular clouds. Here we show that the transition from the embedded to the exposed phase of star formation is short (< 4 Myr) and sometimes almost absent (< 1 Myr) across a sample of 37 nearby star-forming galaxies covering a wide range of morphologies, from massive barred spirals to irregular dwarfs. The short duration of the dust-clearing timescales suggests a predominant role of pre-supernova feedback mechanisms in revealing newborn stars, confirming previous results on smaller samples and allowing, for the first time, a statistical analysis of their dependencies. We find that the timescales associated with mid-infrared emission at 21 μm, tracing a dust-embedded feedback phase, are controlled by a complex interplay between giant molecular cloud properties (masses and velocity dispersions) and galaxy morphology. We report relatively longer durations of the embedded phase of star formation in barred spiral galaxies, while this phase is significantly reduced in low-mass irregular dwarf galaxies. We discuss tentative trends with gas-phase metallicity, which may favor faster cloud dispersal at low metallicities.

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Holographic Duality From Howe Duality, Anatoly Dymarsky, Johan Henriksson, Brian Mcpeak Feb 2026

Holographic Duality From Howe Duality, Anatoly Dymarsky, Johan Henriksson, Brian Mcpeak

Physics and Astronomy Faculty Publications

We discuss the holographic correspondence between 3d “Chern-Simons gravity” and an ensemble of 2d Narain code CFTs. Starting from 3d abelian Chern-Simons theory, we construct an ensemble of boundary CFTs defined by gauging all possible maximal subgroups of the bulk one-form symmetry. Each maximal non-anomalous subgroup is isomorphic to a classical even self-dual error-correcting code over ℤp × ℤp, providing a way to define a boundary “code CFT.” The average over the ensemble of such theories is holographically dual to Chern-Simons gravity, a bulk theory summed over 3d topologies sharing the same boundary. In the case of …

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From Leaky Pipelines To Watering Cans, Samantha Fladd, Sarah Kurnick, Laura E. Heath-Stout, Nala K. Williams, Sarah Simeonoff, Sasha Buckser, Katelyn J. Bishop, Scott R. Hutson, Jessica Maclellan, Marie Matsuda, Sarah E. Oas, Jocelyne M. Ponce, Bruno Athie Teruel, Jaycee Castro, Breeanna Charolla, Adriana M. De León, Luisa Escobar Galo, Lydia D. Evans, Isabella N. Garcia, Kelsey Hoppes, Elena Lompe Feb 2026

From Leaky Pipelines To Watering Cans, Samantha Fladd, Sarah Kurnick, Laura E. Heath-Stout, Nala K. Williams, Sarah Simeonoff, Sasha Buckser, Katelyn J. Bishop, Scott R. Hutson, Jessica Maclellan, Marie Matsuda, Sarah E. Oas, Jocelyne M. Ponce, Bruno Athie Teruel, Jaycee Castro, Breeanna Charolla, Adriana M. De León, Luisa Escobar Galo, Lydia D. Evans, Isabella N. Garcia, Kelsey Hoppes, Elena Lompe

Anthropology Faculty Publications

Despite improvement over the past few decades, particularly for white, cisgender women, intersectional gender-based inequality remains prominent within anthropological archaeology and beyond. Building on critiques of the leaky pipeline metaphor laid out in the introduction to this themed issue, and drawing on Black, Indigenous, and Posthumanist Feminisms, we advocate for a metaphorical shift focused on care, inclusivity, and diversity—that of a garden. The garden metaphor provides a way to express and explore the complex and intertwined ways disciplinary norms, institutions, and individuals structure and shape experiences in archaeology. After reviewing the garden metaphor and summarizing previous suggestions for improving equity …

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Substantial Variation In Larval Honey Bee Nutrition Within And Among Apis Mellifera Colonies, Rebecca R. Westwick, Clare Rittschof Feb 2026

Substantial Variation In Larval Honey Bee Nutrition Within And Among Apis Mellifera Colonies, Rebecca R. Westwick, Clare Rittschof

Entomology Faculty Publications

Parents have evolved strategies to reduce the risk of malnutrition in offspring, including the production of specialized nutritional secretions that are tailored to meet the unique needs of developing offspring. Studies in vertebrates, however, show abundant individual variation in nutritional secretions; the causes and consequences of this variation, and the extent to which such patterns can be generalized beyond vertebrates, remain unclear. Here, we investigated natural variation in nutritional secretions in an invertebrate species, the Western honey bee (Apis mellifera L.). This is a unique bee wherein developing larvae subsist entirely on “jellies” (e.g., royal jelly) produced by glands in …

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Single-Cell Transcriptomics Of The Drosophila Ring Gland Identifies The Soxn–Vvl Complex As A Key Regulator Of Juvenile Hormone Biosynthesis, Yuhan Luo, Nan Chen, Yue Gao, Wei Luo, Shanshan Liu, Yang Li, Hanyue Wang, Xiangbin Gao, Jiawei Chen, Haosheng Ye, Kirst King-Jones, Subba Reddy Palli, Sheng Li, Suning Liu Feb 2026

Single-Cell Transcriptomics Of The Drosophila Ring Gland Identifies The Soxn–Vvl Complex As A Key Regulator Of Juvenile Hormone Biosynthesis, Yuhan Luo, Nan Chen, Yue Gao, Wei Luo, Shanshan Liu, Yang Li, Hanyue Wang, Xiangbin Gao, Jiawei Chen, Haosheng Ye, Kirst King-Jones, Subba Reddy Palli, Sheng Li, Suning Liu

Entomology Faculty Publications

Juvenile hormone (JH) is essential for maintaining juvenile status and promoting reproduction in insects, yet the transcriptional regulation of JH biosynthesis remains poorly understood. Previous transcriptomic studies of the Drosophila ring gland—which is composed of the corpus allatum (CA), prothoracic gland (PG), and corpora cardiaca (CC)—have treated the ring gland as a single tissue. As a result, these approaches lacked the resolution necessary to dissect JH biosynthesis and its regulation in a cell-type-specific manner. To overcome this limitation, we performed single-cell RNA sequencing (scRNA-seq) of 7,919 cells isolated from the larval ring glands. This analysis resolved distinct transcriptional profiles for …

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Human Atrial Skinned Muscle Fibers Exhibit Reduced Length-Dependent Activation But Show Faster Force Development Kinetics Than Ventricular Muscle, Alexandre Lewalle, Gregory Milburn, Jania Bell, Kenneth S. Campbell, Steven A. Niederer Feb 2026

Human Atrial Skinned Muscle Fibers Exhibit Reduced Length-Dependent Activation But Show Faster Force Development Kinetics Than Ventricular Muscle, Alexandre Lewalle, Gregory Milburn, Jania Bell, Kenneth S. Campbell, Steven A. Niederer

Physiology Faculty Publications

In humans, the left atria (LA) and the left ventricle (LV) play distinct physiological roles and express sarcomeric proteins with chamber-specific patterns. Despite these important differences, most multi-chamber descriptions of the heart assume uniform myocardial properties. To facilitate a more accurate representation of cardiac function, we measured and compared the contractile properties of isolated skinned human LA and LV muscle fibers at 37 °C. Our experimental measurements included the length-dependent activation (LDA) of force in the isometric steady state, the force response to small quick length changes, and tension redevelopment dynamics. The LV measurements display more pronounced LDA behavior compared …

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Hyaluronan 35 Prevents Endotoxin-Mediated Dysregulated Skeletal Muscle Proteostasis During Ethanol Exposure, Nicole Welch, Pugazhendhi Kannan, Gangarao Davuluri, Annette Bellar, Amy H. Attaway, Saurabh Mishra, Jasmin A. Cunningham, Avinash Kumar, Ryan Musich, Elif G. Ertugral, Vandana Agrawal, Isaac L. Hsu, Terri J. Harford, Noah L. Weisleder, Vidula T. Vachharajani, Chandrasekhar R. Kothapalli, Carol A. De La Motte, Laura E. Nagy, Srinivasan Dasarathy Feb 2026

Hyaluronan 35 Prevents Endotoxin-Mediated Dysregulated Skeletal Muscle Proteostasis During Ethanol Exposure, Nicole Welch, Pugazhendhi Kannan, Gangarao Davuluri, Annette Bellar, Amy H. Attaway, Saurabh Mishra, Jasmin A. Cunningham, Avinash Kumar, Ryan Musich, Elif G. Ertugral, Vandana Agrawal, Isaac L. Hsu, Terri J. Harford, Noah L. Weisleder, Vidula T. Vachharajani, Chandrasekhar R. Kothapalli, Carol A. De La Motte, Laura E. Nagy, Srinivasan Dasarathy

Neurology Faculty Publications

Sarcopenia in alcohol-related liver disease (ALD) is of high clinical significance, but there are no effective treatments. Hyaluronan 35 kDa (HA35), a glycosaminoglycan polymer, modulates responses to Toll-like receptor 4 (TLR4), a lipopolysaccharide receptor, to improve hepatic and macrophage function in ALD. We evaluated skeletal muscle responses to HA35 in preclinical models of ALD. Responses to ethanol, lipopolysaccharide (LPS), and HA35 were studied in differentiated murine C2C12/human-induced pluripotent stem cell (hiPSC)-derived myotubes, and wild-type/HA receptor CD44 knockout (CD44—/—) mouse models of ALD (mALD). Signaling molecules and measures of protein homeostasis (proteostasis) were quantified by immunoblots, mitochondrial oxidative function …

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Interannual Variation In Seed Traits Of Cedrela Species, Guadalupe Galíndez, Ana Álvarez, Diana Ceccato, Victoria Rivero, Gisela Malagrina, Tania Bertuzzi, Pablo Saravia, Stavros Nicolás Sola, Carol C. Baskin, Luis Fornes Feb 2026

Interannual Variation In Seed Traits Of Cedrela Species, Guadalupe Galíndez, Ana Álvarez, Diana Ceccato, Victoria Rivero, Gisela Malagrina, Tania Bertuzzi, Pablo Saravia, Stavros Nicolás Sola, Carol C. Baskin, Luis Fornes

Plant and Soil Sciences Faculty Publications

Climate change is altering temperature and precipitation regimes in Argentina, with potential consequences for regeneration and persistence of forest tree species, emphasizing the importance of ex situ seed conservation. We evaluated interannual variation in seed traits, desiccation tolerance, storage behavior, and longevity of Cedrela balansae C. DC. and C. fissilis Vell. (Meliaceae), two endangered native species of subtropical rainforests in Argentina. Both species produced desiccation-tolerant seeds, independently of collection year, seed traits, or climatic conditions. Depending on the species, seed traits and longevity varied across years and showed strong relationships with temperature and precipitation, particularly during seed development. Cedrela balansae …

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Gimyb76, A Meja-Inducible R2r3-Type Transcription Factor, Regulates Licochalcone A Biosynthesis In Licorice (Glycyrrhiza Inflata), Yuping Li, Zhigeng Wu, Jixiang Zhu, Jiangyi Zeng, Yongliang Liu, Jihua Wang, Ling Yuan, Ying Wang, Yongqing Li Feb 2026

Gimyb76, A Meja-Inducible R2r3-Type Transcription Factor, Regulates Licochalcone A Biosynthesis In Licorice (Glycyrrhiza Inflata), Yuping Li, Zhigeng Wu, Jixiang Zhu, Jiangyi Zeng, Yongliang Liu, Jihua Wang, Ling Yuan, Ying Wang, Yongqing Li

Plant and Soil Sciences Faculty Publications

Licochalcone A (LCA) is a characteristic compound in licorice Glycyrrhiza inflata and is widely utilized in pharmaceutical and cosmetic industries. However, the biosynthetic pathway and regulatory mechanisms of LCA remain poorly understood. In this study, we first found the accumulation of LCA is induced by methyl jasmonate (MeJA). Given that MYB transcriptional factors are well-documented as key regulators of flavonoid biosynthesis, we identified a total of 147 GiR2R3-MYB genes in G. inflata, which were classified into 28 subgroups. The chromosome distributions, sequence characteristics, gene structures, duplication events and cis-acting elements were also investigated. Through integrated analysis of GiR2R3-MYBs expression patterns …

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Synthetic Microbial Communities Enhance Tobacco Quality By Driving Bacterial Community Succession And Modulating Metabolite Profiles, Kuifu Men, Huaqiang Xuan, Jingrui Chen, Hongliang Li, Xuwei Chen, Yingle Jiao, Xianchao Shang, Yi Xie, Li Zhang, Long Yang, Ling Yuan, Sitakanta Pattanaik, Xin Hou Feb 2026

Synthetic Microbial Communities Enhance Tobacco Quality By Driving Bacterial Community Succession And Modulating Metabolite Profiles, Kuifu Men, Huaqiang Xuan, Jingrui Chen, Hongliang Li, Xuwei Chen, Yingle Jiao, Xianchao Shang, Yi Xie, Li Zhang, Long Yang, Ling Yuan, Sitakanta Pattanaik, Xin Hou

Plant and Soil Sciences Faculty Publications

The fermentation of cigar tobacco leaves (CTLs) is a critical process driven by microbial activity, which directly influences the degradation of macromolecules and the development of distinctive aromas. However, mechanisms for the directional regulation of this process using defined microbial consortia remain underexplored. This study aimed to construct a synthetic microbial community (SynCom) to enhance the fermentation efficiency and quality of cigar tobacco leaves. Bacillus safensis and Bacillus velezensis with high extracellular cellulase, amylase and protease activities were screened out, and synthetic communities were constructed. This microbial community was applied to cigar tobacco leaves (cultivar QX204) during a 42-day fermentation. …

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Post-Translational Control Of Biotic Stress-Related Nicotine Biosynthesis By A Map Kinase Signaling Cascade, Yan Zhou, Yongliang Liu, Ruiqing Lyu, Sanjay Kumar Singh, Xueyi Sui, Xin Hou, Sitakanta Pattanaik, Ling Yuan Feb 2026

Post-Translational Control Of Biotic Stress-Related Nicotine Biosynthesis By A Map Kinase Signaling Cascade, Yan Zhou, Yongliang Liu, Ruiqing Lyu, Sanjay Kumar Singh, Xueyi Sui, Xin Hou, Sitakanta Pattanaik, Ling Yuan

Plant and Soil Sciences Faculty Publications

The evolutionarily conserved mitogen-activated protein kinase (MAPK) cascades relay extracellular signals into cells, triggering a variety of cellular responses. We previously revealed NtMPK4 as a positive regulator of nicotine biosynthesis; however, its upstream regulation remains unclear. Here, we characterized a MAPK cascade, comprising NtMEKK1b, NtMPKK2a, and NtMPK4, that promotes nicotine biosynthesis. This signaling module transduces external cues, including jasmonate and pathogen elicitors such as flg22, into post-translational modifications that enhance transcriptional activity and pathway gene expression. NtMPKK2a physically interacts with and phosphorylates NtMPK4 in vivo, confirming its role as an upstream kinase. RNAi-mediated silencing of NtMPKK2a significantly reduced the expression …

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Association Of Clinical Severity In Autism Spectrum Disorder With Biomolecules Involved In Lipid Metabolism, Inflammation And Mirnas, Maria Gevezova, Michael Maes, Iliana Pacheva, Nikolay Mehterov, Zdravko Ivanov, Elena Timova, Stefka Spassieva, Erhard Bieberich, Maria Kazakova, Ivan Ivanov, Victoria Sarafian Feb 2026

Association Of Clinical Severity In Autism Spectrum Disorder With Biomolecules Involved In Lipid Metabolism, Inflammation And Mirnas, Maria Gevezova, Michael Maes, Iliana Pacheva, Nikolay Mehterov, Zdravko Ivanov, Elena Timova, Stefka Spassieva, Erhard Bieberich, Maria Kazakova, Ivan Ivanov, Victoria Sarafian

Markey Cancer Center Faculty Publications

Autism spectrum disorder (ASD) is a heterogeneous neurological condition with an unclear etiology and pathogenesis. In recent years, studies have identified changes in lipid metabolism, inflammation, mitochondrial dysfunction, and mitophagy in patients with ASD. However, the specific interactions between these molecular signatures and their clinical applications in ASD remain largely unexplored. The aim of our study is to search for correlations between changes in gene and miRNA expression and the clinical characteristics of ASD. The investigation included a cohort of children with idiopathic ASD and healthy controls (HC). Diagnosis was established based on ADOS assessment (autism diagnostic observation schedule). Gene …

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Outcomes Of Prosthetic Valve Endocarditis Managed By A Multidisciplinary Endocarditis Team, Bennett Collis, Takaaki Kobayashi, Evan Hall, Talal Alnabelsi, Chloe Cao, Meredith Johnson, John Gurley, Hassan Reda, Tessa London, Erinn Ogburn, Michael Sekela, Bobbi Jo Stoner, Sami El-Dalati Feb 2026

Outcomes Of Prosthetic Valve Endocarditis Managed By A Multidisciplinary Endocarditis Team, Bennett Collis, Takaaki Kobayashi, Evan Hall, Talal Alnabelsi, Chloe Cao, Meredith Johnson, John Gurley, Hassan Reda, Tessa London, Erinn Ogburn, Michael Sekela, Bobbi Jo Stoner, Sami El-Dalati

Radiology Faculty Publications

Background: Prosthetic valve endocarditis (PVE) is a serious complication of valve replacement associated with significant morbidity and mortality. However, outcomes for medical vs surgical strategies remain incompletely characterized. Methods: We conducted a retrospective cohort study of adult patients with PVE, defined by modified Duke criteria, evaluated by a multidisciplinary endocarditis team at a tertiary-care centre between September 2021 and February 2024. Demographic, clinical, management, and outcome data were collected. Logistic regression analyses were performed to identify factors associated with in-hospital mortality. Results: Among 67 patients with PVE, 58.2% (n = 39) were managed medically, and 41.8% (n = 28) underwent …

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Successful Biliary Re-Cannulation And Neo-Anastomosis Creation In Complete Bile Duct Occlusion Or Disruption Using A Combination Of Interventional Radiology And Endoscopic Techniques, Joshua G. Fricker, Tarik Babar, Husameddin El Khudari, Ali Ahmed, Dalton Norwood, Sergio A. Sánchez-Luna, Eric Bready, Ramzi Mulki, Kondal Kyanam, Shajan Peter, Andrew Gunn Feb 2026

Successful Biliary Re-Cannulation And Neo-Anastomosis Creation In Complete Bile Duct Occlusion Or Disruption Using A Combination Of Interventional Radiology And Endoscopic Techniques, Joshua G. Fricker, Tarik Babar, Husameddin El Khudari, Ali Ahmed, Dalton Norwood, Sergio A. Sánchez-Luna, Eric Bready, Ramzi Mulki, Kondal Kyanam, Shajan Peter, Andrew Gunn

Radiology Faculty Publications

Aims: Biliary strictures are a known complication of hepatobiliary and pancreatic surgeries. This retrospective descriptive series highlights six consecutive patients with complete bile duct occlusion or disruption who required a multidisciplinary approach with a combination of interventional radiology (IR) and endoscopic techniques to either re-cannulate or create a neo-anastomosis in the biliary system. Methods and Results: The biliary system was either re-cannulated or a neo-anastomosis was created using a small gauge needle (N = 3), a rendezvous procedure (N = 1), a radiofrequency ablation wire (N = 1), and the back end of a wire (N = 1). There was …

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The American College Of Radiology Diagnostic Fluoroscopy Dose Index Registry Pilot, Steve D. Mann, Donald L. Miller, Grant Fong, Allen R. Goode, Emily L. Marshall, Thomas Nishino, Pavlina Boxx, Liqiang Ren, Celalettin Topbas, Alan H. Schoenfeld, Vivek Singh, Jie Zhang Feb 2026

The American College Of Radiology Diagnostic Fluoroscopy Dose Index Registry Pilot, Steve D. Mann, Donald L. Miller, Grant Fong, Allen R. Goode, Emily L. Marshall, Thomas Nishino, Pavlina Boxx, Liqiang Ren, Celalettin Topbas, Alan H. Schoenfeld, Vivek Singh, Jie Zhang

Radiology Faculty Publications

Background: The ACR Diagnostic Fluoroscopy Dose Index Registry (DIR-Fluoro) is expanding to include diagnostic fluoroscopy. Variations in dose reference points and overhead radiography events may introduce unique challenges for benchmarking. Purpose: To survey the technological status and dosimetric performance of fluoroscopes participating in the DIR-Fluoro pilot project, focusing on longitudinal stability and variability of fluoroscopic dose reporting accuracy across multiple institutions and vendors. Methods: Sixty-six fluoroscopic systems from nine institutions (24 facilities) were surveyed for facility type, fluoroscope type, image receptor type, age, dose reporting capabilities, and other key features. Of these, 56 were evaluable. Semi-annual measurements assessed reference air …

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Toward An Emerging Public Health Paradigm, Rod Wallace, Katherine Frels, Maria Itria Ibba, Conrad Lyford, Devin Rose, David Baltensperger, Jan A. Delcour, Steven Greenspan, Alison Lovegrove, Barbara Schneeman, Peter Shewry, Edward Souza, William W. Wilson, Gary W. Yohe, Jim Anderson, George Annor, Jayne Bock, Claudia Carter, Brett Carver, Jianli Chen, Edward C. Deehan, Noah Dewitt, Lisa Diewald, Jason Donovan, Corrine K. Hanson, David Holding, Amir Ibrahim, Mariah Jackson Feb 2026

Toward An Emerging Public Health Paradigm, Rod Wallace, Katherine Frels, Maria Itria Ibba, Conrad Lyford, Devin Rose, David Baltensperger, Jan A. Delcour, Steven Greenspan, Alison Lovegrove, Barbara Schneeman, Peter Shewry, Edward Souza, William W. Wilson, Gary W. Yohe, Jim Anderson, George Annor, Jayne Bock, Claudia Carter, Brett Carver, Jianli Chen, Edward C. Deehan, Noah Dewitt, Lisa Diewald, Jason Donovan, Corrine K. Hanson, David Holding, Amir Ibrahim, Mariah Jackson

Animal and Food Sciences Faculty Publications

An emerging paradigm in public health focuses on enhancing nutrition in existing food staples to reduce chronic disease at the population scale, rather than relying on individuals to change their behavior. This paradigm leverages plant and animal breeding, production practices, and processing to enhance nutrition, whereby foods consumed by millions can be improved at low incremental cost. This article supports and operationalizes this paradigm, illustrating the potential to improve diets through a case study that increases the arabinoxylan fiber content of commodity wheat through classical plant breeding (a non-GMO technology). The approach described in this article proposes to link agricultural …

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Low Temperature Green Synthesis Of Red Emitting Pb-Free Csmnbr3Perovskite Films, Saurabh Singh, Xiyu Wen, Fuqian Yang Jan 2026

Low Temperature Green Synthesis Of Red Emitting Pb-Free Csmnbr3Perovskite Films, Saurabh Singh, Xiyu Wen, Fuqian Yang

Chemical and Materials Engineering Faculty Publications

Lead halide perovskites (APbX3) have demonstrated exceptional opto-electronic properties, but their inherent toxicity and environmental hazards hindered their practical deployment in display technologies such as liquid crystal display (LCD) backlights. Herein, we report for the first time a facile, water-mediated synthesis of red-emitting CsMnBr3 thin films from an aqueous solution of CsBr and MnBr2 precursors at a low temperature of ∼50 °C. Unlike traditional synthesis routes reported for synthesis of CsMnBr3 powders or nanocrystals, relying heavily on toxic solvents, high temperatures, or inert atmospheres, the green approach utilizes water as a benign medium to facilitate …

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High-Throughput Screens Identify Genotype-Specific Therapeutics For Channelopathies, Christian L. Egly, Alex Shen, Tri Q. Do, Carlos Tellet Cabiya, Paxton A. Ritschel, Suah Woo, Matthew Ku, Brian P. Delisle, Brett M. Kroncke, Björn C. Knollmann Jan 2026

High-Throughput Screens Identify Genotype-Specific Therapeutics For Channelopathies, Christian L. Egly, Alex Shen, Tri Q. Do, Carlos Tellet Cabiya, Paxton A. Ritschel, Suah Woo, Matthew Ku, Brian P. Delisle, Brett M. Kroncke, Björn C. Knollmann

Physiology Faculty Publications

Genetic diseases such as ion channelopathies substantially burden human health. Existing treatments are limited and not genotype specific. Here, we report a 2-step high-throughput approach to rapidly identify drug candidates for repurposing as genotype-specific therapy. We first screened 1,680 medicines using a thallium-flux trafficking assay against Kv11.1 gene variants causing long QT syndrome (LQTS), an ion channelopathy associated with fatal cardiac arrhythmia. We identified evacetrapib as a suitable drug candidate that improves membrane trafficking and activates channels. We then used deep mutational scanning to prospectively identify all Kv11.1 missense variants in an LQTS hotspot region responsive to treatment with evacetrapib. …

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Sustained Increase In Extracellular Atp In The Lung Induced By Chronic Inhalation Exposure To Nitrogen Dioxide, Nai Ju Chan, Yueh Yin Chen, Chun Chun Hsu, You Shuei Lin, Maxwell Zakeri, Mehdi Khosravi, Lu Yuan Lee Jan 2026

Sustained Increase In Extracellular Atp In The Lung Induced By Chronic Inhalation Exposure To Nitrogen Dioxide, Nai Ju Chan, Yueh Yin Chen, Chun Chun Hsu, You Shuei Lin, Maxwell Zakeri, Mehdi Khosravi, Lu Yuan Lee

Physiology Faculty Publications

Nitrogen dioxide (NO2) is an environmental air pollutant and a potent oxidant. Epidemiological studies have revealed a close association between chronic cough and long-term inhalation exposure to NO2. ATP can be released from airway/lung epithelial cells upon inhalation exposure to oxidants, and convincing evidence established in recent clinical studies indicated that extracellular ATP in the respiratory tract plays an important role in the pathogenesis of refractory chronic cough. However, whether inhalation exposure to NO2 elevates the ATP release in the lung is not yet known. Results of this study showed: 1) in awake rats, acute …

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