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Expanding Karst Groundwater Tracing Techniques: Incorporating Population Genetic And Isotopic Data To Enhance Flow-Path Characterization, Benjamin Tobin, Benjamin V. Miller, Matthew Niemiller, Andrea Erhardt Feb 2024

Expanding Karst Groundwater Tracing Techniques: Incorporating Population Genetic And Isotopic Data To Enhance Flow-Path Characterization, Benjamin Tobin, Benjamin V. Miller, Matthew Niemiller, Andrea Erhardt

Earth and Environmental Sciences Faculty Publications

Karst aquifers are unique among groundwater systems because of variable permeability and flow-path organization changes resulting from dissolution processes. Over time, changes in flow-path connectivity complicate interpretations of conduit network evolution in karst hydrogeology. Natural and artificial tracer techniques have long provided critical information for protecting karst aquifers and understanding the potential impacts on ecosystems and human populations. Conventional tracer methods are useful in karst hydrogeologic studies for delineating flow paths and defining recharge, storage, and discharge properties. However, these methods only provide snapshots of the current conditions and do not provide sufficient information to understand the changes in interconnection …


Pilot Study On Improving Crash Data Accuracy In Kentucky Through University Collaboration, Michael A. Fields, Eric Green, Robert Kluger, Xu Zhang, Kirolos Haleem Feb 2024

Pilot Study On Improving Crash Data Accuracy In Kentucky Through University Collaboration, Michael A. Fields, Eric Green, Robert Kluger, Xu Zhang, Kirolos Haleem

Kentucky Transportation Center Research Report

Without high-quality crash data and robust interpretive/analytical tools to analyze these data, transportation agencies will struggle to develop evidence-based strategies for improving road safety. Crash narratives are one element of crash reports that pose especially acute interpretive challenges. These narratives supplement coded data and give an account of incidents authored by responding law enforcement officers. Despite their value, conducting manual reviews of the 150,000+ crash reports and narratives issued in Kentucky each year is not feasible. To address this challenge, reviewers examined approximately 8,000 crash narratives from calendar year 2020 using a proprietary web-based quality control tool to identify discrepancies …


Advancing Universal Id Through Demonstration Of Enabling Technologies, Joseph Crabtree, Andrew Martin, Jeeyen Koo, Brian Beaven Feb 2024

Advancing Universal Id Through Demonstration Of Enabling Technologies, Joseph Crabtree, Andrew Martin, Jeeyen Koo, Brian Beaven

Kentucky Transportation Center Research Report

The purpose of this project was to install, demonstrate, and evaluate two candidate technologies that could be used to achieve “Universal ID” (i.e., having a unique, electronically readable identifier on every commercial motor vehicle in the United States). The two technologies selected for this demonstration represent (1) a potential low-cost near-term solution (simple RFID tags and roadside readers) and (2) a potential future solution that leverages technology that is anticipated to be installed on all future vehicles to support a variety of connected-vehicle (CV) applications. For this demonstration project, both types of roadside reader technology were installed at three existing …


Attention-Deficit/Hyperactivity Disorder And The Menstrual Cycle: Theory And Evidence., Ashley G. Eng, Urveesha Nirjar, Anjeli Elkins, Yancey J. Sizemore, Krystina N. Monticello, Madeline K. Petersen, Sarah A. Miller, Jordan Barone, Tory A. Eisenlohr-Moul, Michelle M. Martel Feb 2024

Attention-Deficit/Hyperactivity Disorder And The Menstrual Cycle: Theory And Evidence., Ashley G. Eng, Urveesha Nirjar, Anjeli Elkins, Yancey J. Sizemore, Krystina N. Monticello, Madeline K. Petersen, Sarah A. Miller, Jordan Barone, Tory A. Eisenlohr-Moul, Michelle M. Martel

Psychology Faculty Publications

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that exhibits striking sex differences in symptoms, prevalence, and associated problems across development. Etiological factors and mechanisms underlying these sex differences remain one of the most understudied aspects of this disorder. The current paper seeks to provide a novel theoretical framework for understanding this phenomenon by reviewing evidence that females with ADHD may experience a "double whammy" of organizational and activational pubertal hormonal effects. We propose a novel theory of activational effects of cyclical circulating ovarian hormones on ADHD with increasing risk at times of rapid declines in estrogen. These declines may decrease …


Inhibited Surface Diffusion In Nanoporous Multi-Principal Element Alloy Thin Films Prepared By Vacuum Thermal Dealloying, Tibra Das Gupta, Thomas John Balk Feb 2024

Inhibited Surface Diffusion In Nanoporous Multi-Principal Element Alloy Thin Films Prepared By Vacuum Thermal Dealloying, Tibra Das Gupta, Thomas John Balk

Chemical and Materials Engineering Faculty Publications

Nanoporous structures with 3D interconnected networks are traditionally made by dealloy- ing a binary precursor. Certain approaches for fabricating these materials have been applied to refrac- tory multi-principal element alloys (RMPEAs), which can be suitable candidates for high-temperature applications. In this study, nanoporous refractory multi-principal element alloys (np-RMPEAs) were fabricated from magnesium-based thin films (VMoNbTaMg) that had been prepared by magnetron sputtering. Vacuum thermal dealloying (VTD), which involves sublimation of a higher vapor pres- sure element, is a novel technique for synthesizing nanoporous refractory elements that are prone to oxidation. When VMoNbTaMg was heated under vacuum, a nanoporous structure was …


Alzheimer’S Disease And Inflammatory Biomarkers Positively Correlate In Plasma In The Uk-Adrc Cohort, Kate E. Foley, Zachary Winder, Tiffany L. Sudduth, Barbara J. Martin, Peter T. Nelson, Gregory Jicha, Jordan P. Harp, Erica M. Weekman, Donna M. Wilcock Feb 2024

Alzheimer’S Disease And Inflammatory Biomarkers Positively Correlate In Plasma In The Uk-Adrc Cohort, Kate E. Foley, Zachary Winder, Tiffany L. Sudduth, Barbara J. Martin, Peter T. Nelson, Gregory Jicha, Jordan P. Harp, Erica M. Weekman, Donna M. Wilcock

Neurology Faculty Publications

INTRODUCTION: Protein-based plasma assays provide hope for improving accessibility and specificity of molecular diagnostics to diagnose dementia. METHODS: Plasma was obtained from participants (N = 837) in our community-based University of Kentucky Alzheimer’s Disease Research Center cohort. We evaluated six Alzheimer’s disease (AD)- and neurodegeneration-related (Aβ40, Aβ42, Aβ42/40, p- tau181, total tau, and NfLight) and five inflammatory biomarkers (TNF𝛼, IL6, IL8, IL10, and GFAP) using the SIMOA-based protein assay platform. Statistics were performed to assess correlations. RESULTS: Our large cohort reflects previous plasma biomarker findings. Relationships between biomarkers to understand AD–inflammatory biomarker correlations showed significant associations between AD and inflammatory …


Current Practices, Perceived Barriers, And Promising Implementation Strategies For Improving Quality Of Smoking Cessation Support In Accredited Cancer Programs Of The American College Of Surgeons., Jamie S. Ostroff, Eileen M. Reilly, Jessica L. Burris, Graham W. Warren, Rachel C. Shelton, Timothy W. Mullett, Just Ask Quality Improvement Task Force Feb 2024

Current Practices, Perceived Barriers, And Promising Implementation Strategies For Improving Quality Of Smoking Cessation Support In Accredited Cancer Programs Of The American College Of Surgeons., Jamie S. Ostroff, Eileen M. Reilly, Jessica L. Burris, Graham W. Warren, Rachel C. Shelton, Timothy W. Mullett, Just Ask Quality Improvement Task Force

Psychology Faculty Publications

PURPOSE: Persistent smoking is associated with poor outcomes in cancer care. It is strongly recommended that oncology care providers provide cessation support; however, there is limited information about smoking cessation assessment and treatment patterns in routine oncology practice.

METHODS: Leaders of the American College of Surgeons Commission on Cancer (CoC) and National Accreditation Program for Breast Centers (National Accredited Program for Breast Cancer) elected to participate in a national quality improvement initiative (Just ASK) focused on smoking assessment/treatment in cancer care. Online baseline survey responses were received from 762 accredited programs.

RESULTS: Most programs reported regularly asking about smoking (89.9%), …


Pathologic Correlates Of Aging-Related Tau Astrogliopathy: Artag Is Associated With Late-Nc And Cerebrovascular Pathologies, But Not With Adnc, Yuriko Katsumata, Xian Wu, Khine Zin Aung, Kathryn Gauthreaux, Charles Mock, Shelley L. Forrest, Gabor G. Kovacs, Peter T. Nelson Feb 2024

Pathologic Correlates Of Aging-Related Tau Astrogliopathy: Artag Is Associated With Late-Nc And Cerebrovascular Pathologies, But Not With Adnc, Yuriko Katsumata, Xian Wu, Khine Zin Aung, Kathryn Gauthreaux, Charles Mock, Shelley L. Forrest, Gabor G. Kovacs, Peter T. Nelson

Neurology Faculty Publications

Age-related tau astrogliopathy (ARTAG) is detectable in the brains of over one-third of autopsied persons beyond age 80, but the pathoetiology of ARTAG is poorly understood. Insights can be gained by analyzing risk factors and comorbid pathologies. Here we addressed the question of which prevalent co-pathologies are observed with increased frequency in brains with ARTAG. The study sample was the National Alzheimer’s Coordinating Center (NACC) data set, derived from multiple Alzheimer’s disease research centers (ADRCs) in the United States. Data from persons with unusual conditions (e.g. frontotemporal dementia) were excluded leaving 504 individual autopsied research participants, clustering from 20 different …


The Roles Of Carbonaceous Wastes For Catalysis, Energy, And Environmental Remediation, Chi Huey Ng, Mohd Aizzan Mistoh, Siow Hwa Teo, Andrea Galassi, Hin Taufiq-Yap, Nancy Julius Siambun, Jurry Foo, Coswald Stephen Sipaut, Jeffrey Seay, Jidon Janaun Feb 2024

The Roles Of Carbonaceous Wastes For Catalysis, Energy, And Environmental Remediation, Chi Huey Ng, Mohd Aizzan Mistoh, Siow Hwa Teo, Andrea Galassi, Hin Taufiq-Yap, Nancy Julius Siambun, Jurry Foo, Coswald Stephen Sipaut, Jeffrey Seay, Jidon Janaun

Chemical and Materials Engineering Faculty Publications

This article reviews recent studies about various generations of the carbon materials for their applications in energy and environmental remediation. The synthesis routes of the carbon materials including the condition parameters, interaction of precursors, dopants and carbon materials, as well as their physical/chemical properties are explicated first. Then, the application and mechanism of metal-free/metal-doped/non-metal-doped carbon materials are discussed in detail. Lastly, this review is ended with a summary and invigorating perspectives on the challenges and future directions at the forefront of the catalysis platform to take a step further for real application.


Azithromycin Reduces Hemoglobin-Induced Innate Neuroimmune Activation, Chirayu D. Pandya, Hemendra J. Vekaria, Miriam Zamorano, Amanda L. Trout, Rodney M. Ritzel, Gary Guzman, Christopher Bolden, Patrick G. Sullivan Feb 2024

Azithromycin Reduces Hemoglobin-Induced Innate Neuroimmune Activation, Chirayu D. Pandya, Hemendra J. Vekaria, Miriam Zamorano, Amanda L. Trout, Rodney M. Ritzel, Gary Guzman, Christopher Bolden, Patrick G. Sullivan

Neurology Faculty Publications

Neonatal intraventricular hemorrhage (IVH) releases blood products into the lateral ventricles and brain parenchyma. There are currently no medical treatments for IVH and surgery is used to treat a delayed effect of IVH, post-hemorrhagic hydrocephalus. However, surgery is not a cure for intrinsic brain injury from IVH, and is performed in a subacute time frame. Like many neurological diseases and injuries, innate immune activation is implicated in the pathogenesis of IVH. Innate immune activation is a pharmaceutically targetable mechanism to reduce brain injury and post-hemorrhagic hydrocephalus after IVH. Here, we tested the macrolide antibiotic azithromycin, which has immunomodulatory properties, to …


Amperometric Bio-Sensing Of Lactate And Oxygen Concurrently With Local Field Potentials During Status Epilepticus, Eliana Fernandes, Ana Ledo, Greg A. Gerhardt, Rui M. Barbosa Feb 2024

Amperometric Bio-Sensing Of Lactate And Oxygen Concurrently With Local Field Potentials During Status Epilepticus, Eliana Fernandes, Ana Ledo, Greg A. Gerhardt, Rui M. Barbosa

Neurology Faculty Publications

Epilepsy is a prevalent neurological disorder with a complex pathogenesis and unpredictable nature, presenting limited treatment options in >30 % of affected individuals. Neurometabolic abnormalities have been observed in epilepsy patients, suggesting a disruption in the coupling between neural activity and energy metabolism in the brain. In this study, we employed amperometric biosensors based on a modified carbon fiber microelectrode platform to directly and continuously measure lactate and oxygen dynamics in the brain extracellular space. These biosensors demonstrated high sensitivity, selectivity, and rapid response time, enabling in vivo measurements with high temporal and spatial resolution. In vivo recordings in the …


Hiv-1 Mrna Knockdown With Crispr/Cas9 Enhances Neurocognitive Function, Kristen A. Mclaurin, Hailong Li, Kamel Khalili, Charles F. Mactutus, Rosemarie M. Booze Feb 2024

Hiv-1 Mrna Knockdown With Crispr/Cas9 Enhances Neurocognitive Function, Kristen A. Mclaurin, Hailong Li, Kamel Khalili, Charles F. Mactutus, Rosemarie M. Booze

Neurology Faculty Publications

Mixed glia are infiltrated with HIV-1 virus early in the course of infection leading to the development of a persistent viral reservoir in the central nervous system. Modification of the HIV-1 genome using gene editing techniques, including CRISPR/Cas9, has shown great promise towards eliminating HIV-1 viral reservoirs; whether these techniques are capable of removing HIV-1 viral proteins from mixed glia, however, has not been systematically evaluated. Herein, the efficacy of adeno-associated virus 9 (AAV9)-CRISPR/Cas9 gene editing for eliminating HIV-1 messenger RNA (mRNA) from cortical mixed glia was evaluated in vitro and in vivo. In vitro, a within-subjects experimental design was …


Examination Of Naloxone Dosing Patterns For Opioid Overdose By Emergency Medical Services In Kentucky During Increased Fentanyl Use From 2018 To 2021, Peter Rock, Svetla Slavova, Philip M. Westgate, Aisaku Nakamura, Sharon L. Walsh Feb 2024

Examination Of Naloxone Dosing Patterns For Opioid Overdose By Emergency Medical Services In Kentucky During Increased Fentanyl Use From 2018 To 2021, Peter Rock, Svetla Slavova, Philip M. Westgate, Aisaku Nakamura, Sharon L. Walsh

Biostatistics Faculty Publications

Background: Fatal overdoses involving fentanyl/fentanyl analogs (F/FA) have increased in the US, raising questions about naloxone doses for F/FA overdose reversal. Emergency medical services (EMS) data provide an opportunity to examine naloxone administration changes as fentanyl increases in the illicit opioid supply. Methods: Administered naloxone intranasal-equivalent total dose (INTD) in milligrams (mg) was calculated for Kentucky EMS suspected opioid overdose (SOO) encounters (n=33,846), 2018–2021, and patterns of administration were examined. County-level F/FA availability was measured as 1) proportion of fatal drug overdoses involving F/FA, and 2) F/FA police seizures. Linear mixed models estimated changes in INTD in relation to local …


Exploring The Role Of Sex In The Association Of Late Chronotype On Cardiorespiratory Fitness, J. Matthew Thomas, Philip A. Kern, Heather M. Bush, Sarah J. Robbins, W. Scott Black, Julie S. Pendergast, Jody L. Clasey Feb 2024

Exploring The Role Of Sex In The Association Of Late Chronotype On Cardiorespiratory Fitness, J. Matthew Thomas, Philip A. Kern, Heather M. Bush, Sarah J. Robbins, W. Scott Black, Julie S. Pendergast, Jody L. Clasey

Biostatistics Faculty Publications

Circadian rhythms differ between young adult males and females. For example, males tend to be later chronotypes, preferring later timing of sleep and activity, than females. Likewise, there are sex differences in body composition and cardiorespiratory fitness. Few studies have investigated the association between circadian rhythms, cardiorespiratory fitness, and body composition. We sought to determine whether chronotype and circadian phase were associated with cardiorespiratory fitness, body composition, and anthropometric measures in sedentary males and females. Fifty-nine adults participated in the study. Circadian phase and chronotype were measured using dim light melatonin onset (DLMO) and the Morningness–Eveningness Questionnaire (MEQ) score. We …


Mapping Urban Form Into Local Climate Zones For The Continental Us From 1986–2020, Meng Qi, Chunxue Xu, Wenwen Zhang, Matthias Demuzere, Perry Hystad, Tianjun Lu, Peter James, Benjamin Bechtel, Steve Hankey Feb 2024

Mapping Urban Form Into Local Climate Zones For The Continental Us From 1986–2020, Meng Qi, Chunxue Xu, Wenwen Zhang, Matthias Demuzere, Perry Hystad, Tianjun Lu, Peter James, Benjamin Bechtel, Steve Hankey

Earth and Environmental Sciences Faculty Publications

Urbanization has altered land surface properties driving changes in micro-climates. Urban form influences people’s activities, environmental exposures, and health. Developing detailed and unified longitudinal measures of urban form is essential to quantify these relationships. Local Climate Zones [LCZ] are a culturally-neutral urban form classification scheme. To date, longitudinal LCZ maps at large scales (i.e., national, continental, or global) are not available. We developed an approach to map LCZs for the continental US from 1986 to 2020 at 100 m spatial resolution. We developed lightweight contextual random forest models using a hybrid model development pipeline that leveraged crowdsourced and expert labeling …


Investigating The Structure And Performance Of Electrodes Made By Dry And Wet Slurry Processes, Kubra Uzun, Bhamiti Sharma, Bradley R. Frieberg, Ming Wang, Jiazhi Hu, Anita Li, Xiaosong Huang, Yang-Tse Cheng Feb 2024

Investigating The Structure And Performance Of Electrodes Made By Dry And Wet Slurry Processes, Kubra Uzun, Bhamiti Sharma, Bradley R. Frieberg, Ming Wang, Jiazhi Hu, Anita Li, Xiaosong Huang, Yang-Tse Cheng

Chemical and Materials Engineering Faculty Publications

Performance, cost, and safety are vital factors in producing and handling lithium-ion batteries. Using a dry process reduces the cost and environmental impact of producing large-scale lithium-ion battery electrodes significantly as solvents are eliminated. Thus, in this study, solvent-free dry electrostatic spray deposition (ESD) and conventional slurry processes were compared to uncover the influence of the manufacturing process on thick LiNi 0.8Mn0.1Co 0.1O 2 (NMC 811) positive electrodes. More pressure during calendering was found necessary for the dry-made (dry) electrodes to have the same porosity, leading to more cracks within the NMC particles and better adhesion. At slower discharge rates, …


Cold-Inducible Rna Binding Protein Impedes Breast Tumor Growth In The Pymt Murine Model For Breast Cancer, Daniel A. Lujan, Joey L. Ochoa, Ellen J. Beswick, Tamara A. Howard, Helen J. Hathaway, Nora I. Perrone-Bizzozero, Rebecca S. Hartley Feb 2024

Cold-Inducible Rna Binding Protein Impedes Breast Tumor Growth In The Pymt Murine Model For Breast Cancer, Daniel A. Lujan, Joey L. Ochoa, Ellen J. Beswick, Tamara A. Howard, Helen J. Hathaway, Nora I. Perrone-Bizzozero, Rebecca S. Hartley

Markey Cancer Center Faculty Publications

RNA binding proteins (RBPs) post-transcriptionally regulate gene expression by associating with regulatory sequences in the untranslated regions of mRNAs. Cold-inducible RBP (CIRP) is a stress-induced RBP that was recently shown to modulate inflammation in response to cellular stress, where it increases or decreases pro-tumorigenic (proinflammatory) cytokines in different contexts. CIRP expression is altered in several cancers, including breast cancer, but the effects of CIRP on inflammation in breast cancer is not known. Here, we investigate if CIRP alters growth and the inflammatory profile of breast tumors. Transgenic mice overexpressing CIRP in the mammary epithelium were crossed with the PyMT mouse …


Association Between Circulating Inflammatory Markers And Adult Cancer Risk: A Mendelian Randomization Analysis., James Yarmolinsky, Jamie W. Robinson, Daniela Mariosa, Ville Karhunen, Jian Huang, Niki Dimou, Neil Murphy, Kimberley Burrows, Emmanouil Bouras, Karl Smith-Byrne, Sarah J. Lewis, Tessel E. Galesloot, Lambertus A. Kiemeney, Sita Vermeulen, Paul Martin, Demetrius Albanes, Lifang Hou, Polly A. Newcomb, Emily White, Alicja Wolk, Anna H. Wu, Loïc Le Marchand, Amanda I. Phipps, Daniel D. Buchanan, The International Lung Cancer Consortium, The Practical Consortium, Sizheng Steven Zhao, Dipender Gill, Stephen J. Chanock, Mark P. Purdue, George Davey Smith, Paul Brennan, Karl-Heinz Herzig, Marjo-Riitta Järvelin, Chris I. Amos, Rayjean J. Hung, Abbas Dehghan, Mattias Johansson, Marc J. Gunter, Kostas K. Tsilidis, Richard M. Martin Feb 2024

Association Between Circulating Inflammatory Markers And Adult Cancer Risk: A Mendelian Randomization Analysis., James Yarmolinsky, Jamie W. Robinson, Daniela Mariosa, Ville Karhunen, Jian Huang, Niki Dimou, Neil Murphy, Kimberley Burrows, Emmanouil Bouras, Karl Smith-Byrne, Sarah J. Lewis, Tessel E. Galesloot, Lambertus A. Kiemeney, Sita Vermeulen, Paul Martin, Demetrius Albanes, Lifang Hou, Polly A. Newcomb, Emily White, Alicja Wolk, Anna H. Wu, Loïc Le Marchand, Amanda I. Phipps, Daniel D. Buchanan, The International Lung Cancer Consortium, The Practical Consortium, Sizheng Steven Zhao, Dipender Gill, Stephen J. Chanock, Mark P. Purdue, George Davey Smith, Paul Brennan, Karl-Heinz Herzig, Marjo-Riitta Järvelin, Chris I. Amos, Rayjean J. Hung, Abbas Dehghan, Mattias Johansson, Marc J. Gunter, Kostas K. Tsilidis, Richard M. Martin

Markey Cancer Center Faculty Publications

BACKGROUND: Tumour-promoting inflammation is a "hallmark" of cancer and conventional epidemiological studies have reported links between various inflammatory markers and cancer risk. The causal nature of these relationships and, thus, the suitability of these markers as intervention targets for cancer prevention is unclear.

METHODS: We meta-analysed 6 genome-wide association studies of circulating inflammatory markers comprising 59,969 participants of European ancestry. We then used combined cis-Mendelian randomization and colocalisation analysis to evaluate the causal role of 66 circulating inflammatory markers in risk of 30 adult cancers in 338,294 cancer cases and up to 1,238,345 controls. Genetic instruments for inflammatory markers were …


Concentrations Of Lead And Arsenic In Mother's Milk And Children's Blood In Peruvian Breastfeeding Dyads., Ana Maria Linares, Amanda Thaxton-Wiggins, Jason M Unrine Feb 2024

Concentrations Of Lead And Arsenic In Mother's Milk And Children's Blood In Peruvian Breastfeeding Dyads., Ana Maria Linares, Amanda Thaxton-Wiggins, Jason M Unrine

Nursing Faculty Publications

BACKGROUND: Toxic trace elements could enter human milk through mothers' food consumption, drinking water, air, or incidental soil ingestion, and are of concern to the nursing infant.

RESEARCH AIM: To determine the concentration of toxic trace elements (lead and arsenic) in Peruvian mothers' milk and their association with blood concentrations in their own infants 3-20 months old.

METHOD: This exploratory, cross-sectional study, carried out in Peru, included breastfeeding mother/child dyads (N = 40). Following standardized protocols, biospecimens of human milk and child's blood were collected.

RESULTS: Lead and arsenic concentrations in milk were above the method detection limits in …


A Dyadic Analysis Of Financial Toxicity And Health-Related Quality Of Life Among Bone Marrow Transplant Patients And Their Caregivers., Jean S Edward, Mary Kay Rayens, Laurie E. Mclouth, Lori P Eisele, Joan Scales, Lovoria B. Williams, Gerhard C. Hildebrandt Feb 2024

A Dyadic Analysis Of Financial Toxicity And Health-Related Quality Of Life Among Bone Marrow Transplant Patients And Their Caregivers., Jean S Edward, Mary Kay Rayens, Laurie E. Mclouth, Lori P Eisele, Joan Scales, Lovoria B. Williams, Gerhard C. Hildebrandt

Nursing Faculty Publications

OBJECTIVE: Relatively few dyad-based studies have evaluated the shared psychosocial and financial toxicity (FT) experiences of hematologic patients and their caregivers, especially those undergoing bone marrow transplantations (BMTs). This study evaluated the association of FT with health-related quality of life (QOL) among BMT patient-caregiver dyads.

METHODS: Survey and electronic health record data were collected between April 2021 and January 2022 from BMT patients and their caregivers pre- (T1) and post-intervention (T2). Thirty-four patient-caregiver dyads completed surveys; all dyads included a patient experiencing elevated T1 FT. The effect of the total FT score (i.e., the combination of psychological response, coping behaviors, …


Feasibility And Clinical Utility Of Reporting Hereditary Cancer Predisposition Pathogenic Variants Identified In Research Germline Sequencing: A Prospective Interventional Study, Megan L. Hutchcraft, Shulin Zhang, Nan Lin, Justine C. Pickarski, Elizabeth Belcher, Sainan Wei, Therese J. Bocklage, Rachel W. Miller, John L. Villano, Michael J. Cavnar, Joseph Kim, Susanne M. Arnold, Frederick R. Ueland, Jill M. Kolesar Jan 2024

Feasibility And Clinical Utility Of Reporting Hereditary Cancer Predisposition Pathogenic Variants Identified In Research Germline Sequencing: A Prospective Interventional Study, Megan L. Hutchcraft, Shulin Zhang, Nan Lin, Justine C. Pickarski, Elizabeth Belcher, Sainan Wei, Therese J. Bocklage, Rachel W. Miller, John L. Villano, Michael J. Cavnar, Joseph Kim, Susanne M. Arnold, Frederick R. Ueland, Jill M. Kolesar

Markey Cancer Center Faculty Publications

PURPOSE

Patients with cancer frequently undergo research-grade germline sequencing but clinically actionable results are not routinely disclosed. The objective of this study is to evaluate the feasibility of reporting clinically relevant sec- ondary findings (SF) identified in germline research sequencing using the institutional molecular tumor board (MTB) and the treating oncology physician.

METHODS

This prospective, interventional cohort study enrolled Total Cancer Care par- ticipants with any cancer diagnosis at a single institution. Patients underwent research-grade germline whole-exome sequencing, with bioinformatic anal- ysis in a Clinical Laboratory Improvement Amendments–certified laboratory to verify pathogenic/likely pathogenic germline variants (PGVs) in any American College …


Joint Map Of Hardin County, Kentucky, Steven L. Martin, Emily Morris Jan 2024

Joint Map Of Hardin County, Kentucky, Steven L. Martin, Emily Morris

Map and Chart--KGS

New field mapping of joints with previously published joint and fault locations. This fracture map can be used as a critical data source for hydrological, karst or geotechnical applications. Joint orientations were measured in 2009, 2022 and 2023, and are combined with joint and fault locations for Hardin County, Kentucky from 1:24,000-scale USGS geologic quadrangle maps that were published from 1962 to 1977. The geologic quadrangle maps for the county were digitized from 2002 to 2007.

The geology of Hardin County consists of Upper Devonian New Albany Shale overlain by Lower to Upper Mississippian-age sequences of limestone, dolomite, sandstone and …


Geodatabase And Modeling Code Used For Dynamic Landslide Hazard Maps In Eastern Kentucky, Nathaniel O'Leary, L. Sebastian Bryson Jan 2024

Geodatabase And Modeling Code Used For Dynamic Landslide Hazard Maps In Eastern Kentucky, Nathaniel O'Leary, L. Sebastian Bryson

Earth and Environmental Sciences Research Data

We developed spatiotemporal landslide hazard maps (LHMs) using soil, hydrologic, and geomorphic parameters from the subaerial infinite slope factor of safety (FS) equation under unsaturated conditions. Soil properties were extracted from the NRCS WSS, while geomorphic variables were derived from a 1.5 m LiDAR-based DEM and ArcGIS Online. Soil moisture from Hydrus-1D, driven by precipitation and evapotranspiration (ET) data from Irrigation Manager, introduced temporal variability. Validation against known landslide sites showed spatial and temporal FS accuracy despite some false positives. We also developed a landslide susceptibility maps (LSM) after comparing three machine learning algorithms, with bagged trees achieving the highest …


Designing Dual-Purpose Management Strategies For Sheep Production And Pollinators In Dryland Pastures, Mia Caudillo, Andony Melathopoulos, Mary Smallman, Sarah A. Kinkaid, David E. Prado-Tarango, Serkan Ates Jan 2024

Designing Dual-Purpose Management Strategies For Sheep Production And Pollinators In Dryland Pastures, Mia Caudillo, Andony Melathopoulos, Mary Smallman, Sarah A. Kinkaid, David E. Prado-Tarango, Serkan Ates

IGC Proceedings (1977-2023)

Development of novel grazing management practicesfor both livestock production and pollinator health is becoming increasingly crucial in pasture-based farming systems. The effect of pasture type and spring closing dates on lamb liveweight gain, pasture production, botanical composition, bloom density and bee visitation was monitored over 2 years at the Oregon State University in Corvallis. Total annual dry matter yield (DMY) of diverse pastures in 2020/2021 was 8.8 t DM ha-1 and this was greater (P-1) and legume pastures (6.6 t DM ha-1). In successive years, lambs grew faster in legume pastures (287, 215 g per head d …


Tillering Of ‘Marandu’ Brachiaria Under Different Nitrogen Rates In The Brazilian Savannah, A. B. O. Assis, A. L. Bocchi, T. C. Pedrosa, A. O. Matos, A. P. B. Soares Jan 2024

Tillering Of ‘Marandu’ Brachiaria Under Different Nitrogen Rates In The Brazilian Savannah, A. B. O. Assis, A. L. Bocchi, T. C. Pedrosa, A. O. Matos, A. P. B. Soares

IGC Proceedings (1977-2023)

The tiller is the basic unit of grass growth and tiller density determines the horizontal ground cover, leaves production and pastures perennially. The objective in this study was to quantify the number of aerial and basal tillers and basal:aerial tillers ratio in Urochloa brizantha cv. Marandu, established in Brazilian savannah, submitted to nitrogen doses (0, 50, 100 and 150 kg N/ha). The experiment was carried out in the Forage and Pasture Sector of Jataí Federal University (UFJ) and after soil correction and fertilization, plots were established with Marandu palisade grass in a randomized block design, with four replications and four …


Effect Of Soil Source And Variety On The Heavy Metal Contents Of Guinea Grass, C. C. Anotaenwere, P. O. Bankole, P. A. Dele, Alaba O. Jolaosho Jan 2024

Effect Of Soil Source And Variety On The Heavy Metal Contents Of Guinea Grass, C. C. Anotaenwere, P. O. Bankole, P. A. Dele, Alaba O. Jolaosho

IGC Proceedings (1977-2023)

The aim of this study was to evaluate the heavy metal content in soils and grasses planted on selected contaminated soils. The study was a 3 x 2 factorial experiment in a completely randomized design comprising of two factors which are: 3 soil sources (i.e., industrial site, dump site and Fadama (a lowland around a river/stream) which was used as the control) and 2 varieties of Megathyrsus maximus (var. Local and Ntchisi) replicated four times. Soils were collected from the three sites and planting was done in a greenhouse. Soil samples were collected before and after planting. Samples of the …


Effect Of Nitrogen Source And Age At Harvest On The In Vitro Digestibility Of Oba Super Ii Maize Fodder, C. C. Anotaenwere, P. A. Dele, F. E. Salawu, B. T. Akinyemi, O. A. Okukenu, Alaba O. Jolaosho Jan 2024

Effect Of Nitrogen Source And Age At Harvest On The In Vitro Digestibility Of Oba Super Ii Maize Fodder, C. C. Anotaenwere, P. A. Dele, F. E. Salawu, B. T. Akinyemi, O. A. Okukenu, Alaba O. Jolaosho

IGC Proceedings (1977-2023)

This experiment was carried out in the Pasture Section of the Directorate of University farms and the laboratory of Department of Pasture and Range Management, Federal University of Agriculture, Abeokuta, Nigeria, to evaluate the effect of nitrogen source (Swine manure, N.P.K. 15:15:15 as well as the control) and age at harvest on the in vitro gas production and digestibility of Oba Super II maize fodder. The experiment was in a split plot design. The nitrogen source was applied at the rate of 120 kgN/ha two weeks after planting. Maize was harvested at 8, 10 and 12 weeks after planting, oven …


Harvest Time Determine Biomass And Nutritive Value Of Forage Soybean In The Northwestern Loess Plateau Of China, An Dong, Jean Marie Vianney Nsigayehe, Y. Y. Shen Jan 2024

Harvest Time Determine Biomass And Nutritive Value Of Forage Soybean In The Northwestern Loess Plateau Of China, An Dong, Jean Marie Vianney Nsigayehe, Y. Y. Shen

IGC Proceedings (1977-2023)

Soybean is a critical legume crop, which can be used as high protein forage in a crop-forage rotation system to supplement forage and increase system productivity. According to the actual production demand, selecting a suitable harvest time and the best feeding variety of soybean can provide a theoretical basis for applying forage soybean in a rotation system. In this study, four forage soybean varieties were selected in the Loess Plateau of northwest China. They were harvested on three dates suitable for local rotation conditions, and their biomass and nutritive value were evaluated. At the early harvest (20 August), the nutritive …


Developing A Simple Bioassay For Detection Of Alfalfa Autotoxicity In Field Soils, P. Baisley, K. Cassida, S. Gruss, E. Hill Jan 2024

Developing A Simple Bioassay For Detection Of Alfalfa Autotoxicity In Field Soils, P. Baisley, K. Cassida, S. Gruss, E. Hill

IGC Proceedings (1977-2023)

Alfalfa autotoxicity causes yield reductions in alfalfa production by inhibiting plant establishment and decreasing plant productivity. Accurate predictions regarding autotoxic potential of the soil in a given field at a given time are an essential tool for alfalfa growers to make appropriate planting decisions. To address this issue, we are developing a soil bioassay that can be conducted as a mail-in soil test for alfalfa growers through plant diagnostic service laboratories. We hypothesize that we will detect differences in seed germination, emergence, root length, and root morphology between control and autotoxic soils. A preliminary trial testing alfalfa field soils and …


Phyllochron And Growth Dynamic Of Lolium Perenne L. And Bromus Valdivianus Phil. As Affected By Soil Ph, Phosphorus And Nitrogen Restriction, Oscar A. Balocchi, M. F. Alonso, I. Calvache Jan 2024

Phyllochron And Growth Dynamic Of Lolium Perenne L. And Bromus Valdivianus Phil. As Affected By Soil Ph, Phosphorus And Nitrogen Restriction, Oscar A. Balocchi, M. F. Alonso, I. Calvache

IGC Proceedings (1977-2023)

Permanent grasslands are the main food for livestock production systems in Southern Chile. Therefore, it is essential to develop management tools that optimize the use of pastures. Among these tools, the phyllochron could be a better method to control grazing frequency. The aim of this study was to determine the effect of three levels of soil pH, phosphorus (P) and nitrogen (N) on the phyllochron and growth dynamic of Lolium perenne and Bromus valdivianus. Nine monophytic mini-swards of each species were established in 125 L containers for three different pH, P and N levels. For one year we measured: …