Digital Commons Network^™

Advancements In Apoe And Dementia Research: Highlights From The 2023 Aaic Advancements: Apoe Conference., Courtney M Kloske, Michael E Belloy, Elizabeth E Blue, Gregory R Bowman, Maria C Carrillo, Xiaoying Chen, Ornit Chiba-Falek, Albert A Davis, Gilbert Di Paolo, Francesca Garretti, David Gate, Lesley R. Golden, Jay W Heinecke, Joachim Herz, Yadong Huang, Costantino Iadecola, Lance A Johnson, Takahisa Kanekiyo, Celeste M Karch, Anastasia Khvorova, Sascha J Koppes-Den Hertog, Bruce T Lamb, Paige E Lawler, Yann Le Guen, Alexandra Litvinchuk, Chia-Chen Liu, Simin Mahinrad, Edoardo Marcora, Claudia Marino, Danny M Michaelson, Justin J Miller, Josh M. Morganti, Priyanka S Narayan, Michel S Naslavsky, Marlies Oosthoek, Kapil V Ramachandran, Abhirami Ramakrishnan, Ana-Caroline Raulin, Aiko Robert, Rasha N M Saleh, Claire Sexton, Nilomi Shah, Francis Shue, Isabel J Sible, Andrea Soranno, Michael R Strickland, Julia Tcw, Manon Thierry, Li-Huei Tsai, Ryan A Tuckey, Jason D Ulrich, Rik Van Der Kant, Na Wang, Cheryl L Wellington, Stacie C Weninger, Hussein N Yassine, Na Zhao, Guojun Bu, Alison M Goate, David M Holtzman

Physiology Faculty Publications

INTRODUCTION: The apolipoprotein E gene (APOE) is an established central player in the pathogenesis of Alzheimer's disease (AD), with distinct apoE isoforms exerting diverse effects. apoE influences not only amyloid-beta and tau pathologies but also lipid and energy metabolism, neuroinflammation, cerebral vascular health, and sex-dependent disease manifestations. Furthermore, ancestral background may significantly impact the link between APOE and AD, underscoring the need for more inclusive research.

METHODS: In 2023, the Alzheimer's Association convened multidisciplinary researchers at the "AAIC Advancements: APOE" conference to discuss various topics, including apoE isoforms and their roles in AD pathogenesis, progress in apoE-targeted therapeutic strategies, updates …

Investigating Effectiveness Of Inverted Classroom In Undergraduate Statistics Education, Xin Ma, Jing Zhang, Petya Karkelanova, Michael C. Osborne, Anushka Karkelanova

Educational, School, and Counseling Psychology Faculty Publications

Data collected from an educational experiment were analyzed to investigate the effectiveness of an instructional reform referred to as the inverted classroom (learning activities traditionally taking place inside the classroom now take place outside the classroom and vice versa) in undergraduate statistics education. Students were taught the same statistics course in the inverted classroom (135 students) and the traditional classroom (135 students) over one semester. A small sample HLM (hierarchical linear modeling) approach was used to account for the data structure of students nested within 12 sections of the course and small sample sizes at both student and section levels. …

Therapeutics For Sickle Cell Disease Intravascular Hemolysis, Jianyao Xue, Xiang-An Li

Markey Cancer Center Faculty Publications

Sickle cell disease (SCD) is a genetic disorder predominantly affecting individuals of African descent, with a significant global health burden. SCD is characterized by intravascular hemolysis, driven by the polymerization of mutated hemoglobin within red blood cells (RBCs), leading to vascular inflammation, organ damage, and heme toxicity. Clinical manifestations include acute pain crises, hemolytic anemia, and multi-organ dysfunction, imposing substantial morbidity and mortality challenges. Current therapeutic strategies mitigate these complications by increasing the concentration of RBCs with normal hemoglobin via transfusion, inducing fetal hemoglobin, restoring nitric oxide signaling, inhibiting platelet-endothelium interaction, and stabilizing hemoglobin in its oxygenated state. While hydroxyurea …

Novel Psychoplastogen Dm506 Reduces Cue-Induced Heroin-Seeking And Inhibits Tonic Gaba Currents In The Prelimbic Cortex, Kassandra Looschen, Shailesh N. Khatri, Malabika Maulik, Colin Salisbury, Alaina F. Carman, Katilyn Corriveau, Colton Smith, Dina Manetti, Maria Novella Romanelli, Hugo R. Arias, Cassandra D. Gipson, Swarup Mitra

Markey Cancer Center Faculty Publications

Opioid use disorder is a major public health crisis that is manifested by persistent drug-seeking behavior and high relapse frequency. Most of the available treatments rely on targeting opioid receptors using small molecules that do not provide sustained symptom alleviation. Psychoplastogens are a novel class of non-opioid drugs that produce rapid and sustained effects on neuronal plasticity, intended to produce therapeutic benefits. Ibogalogs are synthetic derivatives of iboga alkaloids that lack hallucinogenic or adverse side effects. In the current study, we examine the therapeutic potential of DM506, a novel ibogalog lacking any cardiotoxic or hallucinogenic effects, in cue-induced seeking behavior …

Covid-19 And Rates Of Cancer Diagnosis In The Us, Todd Burus, Feitong Lei, Bin Huang, Jay W. Christian, Pamela C. Hull, Amanda R. Ellis, Svetla Slavova, Thomas Tucker, Krystle A. Lang Kuhs

Markey Cancer Center Faculty Publications

IMPORTANCE US cancer diagnoses were substantially lower than expected during the COVID-19 pandemic in 2020. A national study on the extent to which rates recovered in 2021 has not yet been conducted.

OBJECTIVE To examine observed vs expected cancer rate trends for January 2020 to December 2021.

DESIGN, SETTING, AND PARTICIPANTS This cross-sectional, population-based study of cancer incidence trends used the Surveillance, Epidemiology, and End Results 22 (SEER-22) Registries Database, which covers 47.9% of the US population. Included individuals were those with an invasive cancer diagnosis reported to registries included in SEER-22 between January 1, 2000, and December 31, 2021. …

Influence Of Rearing Method On The Behaviour And Welfare Of Assaf Lambs During The Neonatal Period, Miroslav Simeonov, David L. Harmon, Ina Stoycheva

Animal and Food Sciences Faculty Publications

The present study aimed to determine the influence of rearing method on behaviour and welfare in Assaf lambs during the first two weeks of the neonatal period, in an intensive rearing system. The experiment was conducted with 24 Assaf lambs, in which two methods of management were applied – natural rearing (NR) and artificial rearing (AR). Forced separation of lambs from their mothers caused 74% fewer suckling attempts during the first three days of the neonatal period, which reduced suckling time by 57%. The lambs reared under NR, spent more time moving and less time standing and lying. Overall, it …

Depressive Symptoms And Sleep Quality Mediate The Relationship Between Race And Quality Of Life Among Patients With Heart Failure: A Serial Multiple Mediator Model, Jia-Rong Wu, Debra K. Moser, Chin-Yen Lin, Ambrose A. Chiang, Barbara Riegel

UK CARES Faculty Publications

Background: Black patients with heart failure (HF) report worse quality of life (QoL) than White patients. Few investigators have examined mediators of the association between race and QoL, but depressive symptoms and sleep quality are associated with QoL.

Objective: The aim of this study was to determine whether depressive symptoms and sleep quality are mediators of the relationship between race and QoL among patients with HF.

Methods: This was a cross-sectional study. We included 271 outpatients with HF. Self-reported race (White/Black), depressive symptoms (Patient Health Questionnaire), sleep quality (Pittsburgh Sleep Quality Index), and QoL (Kansas City Cardiomyopathy Questionnaire) were collected …

Patient Denial Of Myocardial Infarction In The Prehospital Phase: Prevalence And Correlates, Mona A. Abed, Amani A. Khalil, Debra K. Moser

UK CARES Faculty Publications

Background: Limited knowledge exists regarding patients' denial of myocardial infarction (MI) before hospitalization for an MI. Objective: The aim of this study was to determine the prevalence and correlates of denial of MI in the prehospital phase of a confirmed MI. Methods: This secondary analysis included 166 hospitalized patients (mean [SD] age, 54.1 [10.5] years) who developed MI outside a healthcare facility and had high congruence between their experienced and expected symptoms. Measurements included the Denial subscale of the Brief COPE Inventory, the modified Response to Symptoms Questionnaire, and a Likert scale measuring perceived risk for MI. Patients who arrived …

Linkage Facilitation For Opioid Use Disorder In Criminal Legal System Contexts: A Primer For Researchers, Clinicians, And Legal Practitioners, Milan F. Satcher, Steven Belenko, Anthony Coetzer-Liversage, Khirsten J. Wilson, Michael R. Mccart, Tess K. Drazdowski, Amanda Fallin-Bennett, Nickolas Zaller, Alysse M. Schultheis, Aaron Hogue, Noel Vest, Ashli J. Sheidow, Brandon Del Pozo, Dennis P. Watson, Patrick F. Hibbard, Randy Stevens, L. A. R. Stein

Nursing Faculty Publications

At the intersection of drug policy, the opioid crisis, and fragmented care systems, persons with opioid use disorder (OUD) in the United States are significantly vulnerable to contact with the criminal legal system (CLS). In CLS settings, provision of evidence-based treatment for OUD is variable and often secondary to punitive approaches. Linkage facilitation at every touch point along the CLS Sequential Intercept Model has potential to redirect persons with OUD into recovery-oriented systems of care, increase evidence-based OUD treatment connections, and therefore reduce CLS re-exposure risk. Research in this area is still nascent. Thus, this narrative review explores the state …

Evaluating The Effectiveness Of A Student-Run Clinic On Reducing Cigarette Smoking In A Homeless Population, Briana Taormina, Bryson Jones, Kiah Gledhill Md, Audrey Darville Phd, Aprn, Cpaha-Tt

ePublications of Emerging Medical Research Scholars

Objective

Cigarette smoking remains a major health crisis in the United States, claiming the lives of hundreds of thousands of tobacco users each year. Access to evidence-based smoking cessation remains a challenge for many people that use tobacco products. Prior research demonstrates that the homeless population is exceedingly vulnerable to cigarette smoking and faces more barriers to quitting than their domiciled counterparts. This study explores the effectiveness of a free Smoking Cessation Clinic (SCC) within a homeless shelter for women and children, run by a nurse practitioner and a clinical nurse specialist trained as Tobacco Treatment Specialists, along with two …

Foraging Strategies Of Ruminant Livestock On Intensively Managed Grasslands: Potential And Constraints, I J. Gordon, C Lascano

IGC Proceedings (1977-2023)

All grazed swards exhibit heterogeneity in the spatial (horizontal and vertical) dispersion of species/biomass. A herbivore foraging at random within such a heterogeneous environment would ingest less nutrients than wou Id one which exploited the heterogeneity on offer through selective grazing. The suite of decision-making processes involved in the selective grazing we observe is termed the animal's foraging strategy. On first observation, intensively managed sown swards appear to offer little opportunity for a herbivore to exhibit a foraging strategy; however, opporlunities do exist and there is empirical evidence that herbivores foraging on sown swards tend to have a diet higher …

Comparative Foraging Strategies Of Grazing Ungulates In African Savanna Grasslands, N Owen-Smith, D H.M Cumming

IGC Proceedings (1977-2023)

We review the evolutionary (species-specific) and ecological (individual behavioural) strategies of African grazing ungulates. The contexts considered are free-ranging wild ungulates, traditional livestock pastoralism and extensive commercial ranching. Particularly successful are (1) buffalo, able to digest grass fibre effectively in mesic grasslands; (2) wildebeest, exploiting semi-arid grasslands through migration; (3) megaherbivores (elephant, hippopotamus and white rhinoceros) utilising a wide range of vegetation components. Species-specific adaptations include body size and metabolic rate, digestive efficiency and passage rate, oral and dental anatomy, water dependence and detoxification capacity. Species overlap in grass species se'lected, with dietary differences apparent in grass height favoured, and …

Comparison Of Animal Gains Using Perennial Pastures Exclusively Or Combined With Chicory-Oats-Clover Temporary Winter Pastures, J A. Josifovich

IGC Proceedings (1977-2023)

The increment of winter forage availability using short-rotation pastures could be an interesting way to increase winter carrying capacity. The producer could make good use of higher spring grass production. Sowing oats, rye or chicory alone is quite common in the Argentine Pampa. to evaluate the efficiency of these short-rotation winter pastures a 3 year trial was carried out at Pergamino Experiment Station. The treatments were: a) perennial pastures, 100% of the surface, b) perennial pastures 75%, and chicory-clover 25%, with 2 replications of 3 ha each. The pastures were, for. class II soils, fescue (Festrlca aru11dinacea Schreb.) cv. El …

Influence Of Climatic Factors On Animal Production In The Humid Pampa Of Argentina, J D. Josifovich, E Frutos

IGC Proceedings (1977-2023)

For any' pasture grazing area it is important lo know the relationship among the climatic parameters, rainfall and temperature, with carrying capacity and minimal gains. The availability of pasture to adjust stocking rates and make provisions for hay or supplementary feed needed for periods of shortage can be estimated from these data. Seven years of monthly rainfall and medium average temperature; and 25 years of forage digestibility and average daily gains were related to cattle i: carrying capacity; Analysis was made using the stepwise regression method. Carrying capacity was evaluated considering animal units (AU) for a 400 kg head gaining …

A New Theory Of Feed Intake Regulation In Ruminants And Its Implications For Forage Quality Research, J.J M.H Ketelaars, B J. Tolkamp

IGC Proceedings (1977-2023)

The low voluntary intake of many roughages is commonly explained by a limited physical capacity of ruminants to process fibrous feeds. Recently, we developed a new theory of feed intake regulation assuming feed consumption to create both benefits for the animal (represented by the intake of net energy for maintenance and gain) and costs (represented by the total oxygen consumption of the feeding animal). For non­reproducing ruminants we have shown that voluntary intake of roughages is close to the optimum feed intake level, i.e., the level at which for the animal the ratio between benefits and costs becomes maximum. According …

Botanical Composition Of Forage Samples Selected By Grazing Sheep On The Mountain Rangeland Of Northern China, Han Jianguo, Liu Fuyuan

IGC Proceedings (1977-2023)

Oesophagus fistulae and microscopic examination were used to determine the botanical composition of forage samples selected by grazing sheep on the mountain rangeland in the Hc-Bci Province of northern China during the growing seasons of 1989 and 1990. Results show a clear preference of sheep for some forage species over others. Sheep selected Cleistogenes squarrosa, Koeleria cristata, Potentilla cihinensis, Lespedeza hedysoroides and Scabiosa comosa in each type of rangeland and from early spring to late autumn. The selection ratio of forbs was more than I , and that of grasses less than 1. Sheep showed strong preference for …

The Independent Effects Of Sward Height And Bulk Density On The Bite Parameters Of Romney Ewes And Red Deer Hinds, R J. Mitchell, J Hodgson, D A. Clark

IGC Proceedings (1977-2023)

The independenl effects of sward height (I, 2, 3, 5 and 8 cm) x bulk density (0.65, 1.30, 2.90 mg DM/cm3) variation on the ingestive behaviour of Romney ewes and Red deer hinds were examined in seedling swards which simulated a leafy grass sward of low shear strength. Depth of penetration, horizontal area of herbage severed per bite, weight of each bite and the rate of intake all increased with increasing height, while the rate of biting decreased (P

Relationships Between Milk Yield, Pasture On Offer And Diet Selection In Tropical Grass Pastures, T M. Davison, W N. Orr, V J. Doogan, K Lowe

IGC Proceedings (1977-2023)

A 7-year study was conducted with Holstein-Friesian cows to determine responses to different levels of nitrogen and phosphorus fertiliser applied to Gatton panic (Panicum maximum cv. Gatton) pastures. This study was used to develop relationships between milk yield, pasture and diet botanical components. Multiple regression analysis revealed there was: a negative relation between stem yield (SI) on offer in summer (S) and milk yield but a positive association with leaf yield (L) on offer in summer and green dry matter .GDM in autumn (A),, MY = 2279.0+0.529 LS-0.246 StS+0.324 GDMA _(R2 = 0.66; P

A New Ambulatory Data-Logging System For A Long Term Determination Of Grazing And Rumination Behavior On Free Ranging Cattle, Kanji Matsui, Tadakatu Okubo

IGC Proceedings (1977-2023)

A new ambulatory apparatus (named "jaw recorder") has been developed. The apparatus has a large data storage capacity (32 768 data points), and enables data to be recorded every minute for a minimum of 22 days in one recording session. A Holstein heifer was fitted with the apparatus and was grazed with 4 other heifers for 13 days on a pasture of 0.36 ha of Italian ryegrass (Lolium nmltiflorum Lam.). Grazing and rumination period could be distinguished by a combination of jaw movements and pauses between jaw movements longer than 3 sec/min. Grazing and rumination time distinctly increased with …

Field Test Of Optimal Foraging With Cattle: The Marginal Value Theorem Predicts Patch Selection And Utilization, Emilio A. Laca, R A. Distel, T C. Griggs, G Deo, M W. Demment

IGC Proceedings (1977-2023)

Grazers selectively forage within heterogeneous vegetation. Prediction of intake rate necessitates theoretical developments to understand site selection. We tested III optimal foraging model to predict patch selection by cattle in the field, Nine "grazing environments" (GB) consisting of 16 0.36 m2 patches each were created by mowing. Treatments were a factorial of 3 distances between patches and 3 sets of patch heights. Patch residence time (T,) was accurately predicted (r2=0.89), and increased linearly whh patch distance (P

A Conceptual Model To Explain Variation In Ingestive Behavior Within A Feeding Patch, Emilio M. Laca, M W. Demment, R A. Distel, T C. Griggs

IGC Proceedings (1977-2023)

A conceptual model is presented that links the mechanics of bite formation to the characteristics of the sward to explain variation in bite weight, bite area, bite depth and biting rate measured in a series of experiments with hand-constructed swards. Bite area is determined by the behaviour used by the animal to collect and grasp the tillers, and the length and stiffness of the sward, Bite depth is affected by height and the degree of vertical heterogeneity in stiffness. Time per bite is controlled by bite weight. These mechanisms of bite formation and time per bite ex.plain many observed effects, …

Selective Behaviour Of Cattle Grazing Ryegrass Swards With Horizontal Heterogeneity In Patch Height And Bulk Density, Montague W. Demment, R A. Distel, T C. Griggs, E A. Laca, G P. Deo

IGC Proceedings (1977-2023)

Patches of different height and/or bulk density were created in ryegrass pasture to study selective responses of steers to horizontal variability in patch structure. The experiment involved 3 heterogeneity treatments with 2 patch types each. Steers encountered and entered both patch types available in each treatment with the same frequency. In contrast, they grazed for a longer time (T,) at; and removed more bites (B) from the patch type that yielded greater intake rates. While T, and B varied for a patch type depending on the alternative patch, bite rate and likely bite size were constant for a given patch …

Computer Recording Of The Variation In Intake Of Supplements Provided To Grazing Cattler, R M. Tait, L J. Fisher

IGC Proceedings (1977-2023)

A computer system has been developed to record the consumption of' supplements provided free choice to grazing cattle. The system is based on electronic animal identification and one or more weatherproof electronic scales located in simple feed stations connected by telephone cable to a computer at a distance of up to 1 km. The software program identifies and records individual animals, • time and duration of visits, and the quantity of supplement consumed. The system has been tested in the field using 40 kg molasses-based feed blocks with up to 20 steers per feed station in paddocks of approximately 4 …

Diet Selection By Lambs In Ryegrass-White Clover Swards Differing In The Horizontal Distribution Of Clover, R H. Armstrong, E Robertson, C S. Lamb, I J. Gordon, D A. Elston

IGC Proceedings (1977-2023)

Weaned 5-month-old lambs grazed 2 series of perennial ryegrass (Lolium perenne L.) plots containing patches of mixed perennial ryegrass and white clover (Trifolium repens L.) varying in either a) the size of patches or b) the distance between patches. Both series embraced the same range of percentages (1-25) of ryegrass-clover patches in each plot. Diet composition was estimated from the pattern of naturAI alkanes in faeces collected between days 6 to 15 after allocation of the lambs to the treatments. The percentage of clover in the diet declined markedly from days 6 to 11 and thereafter increased slightly. Dietary …

Influence Of Ectoparasites On Ingestive And Meristic Behavior Of Grazing Beef Cattle, C T. Dougherty, F W. Knapp, P B. Burrus, N W. Bradley

IGC Proceedings (1977-2023)

Face flies (Musca autumnalis De Geer) and slable flies (Stomoxys calcitrans L.) were raised in the laboralory and released into 12 enclosures, each with I grazing cow (Bos taurus L.). Releases of 0, 400 and 800 face flies gave 3, 53 and 64 lighted flies/cow, respectively, with 30/head al the 400 and 800 levels, and eliciled head (2, 60 and 39/h), ears (8, 1337 and 859/h), tails (24, 191 and 606/h) movements and skin twitches (1 side) (15, 210 and 248/h) but did not induce leg movements or affect number of feeding stations visited (188/h), Face flies …

Dung Bags To Prevent Dung Pat Formation In Pasture By Grazing Cattle, Sakurai Mosaku

IGC Proceedings (1977-2023)

In order to prevent dung pat formation on intensively grazed pasture in the humid temperate zone, a modified dung bag was made. Results from a preliminary study showed that smaller dung lumps dropped in the pasture resulted in the period of rejection being shorter and the rejected area being smaller or non existent. The dung bag was remodeled and fitted to the milking cows. After excretion the dung is held in the dung bag. From a hole in the bottom of the bag smaller dung lumps fall to the pasture. Therefore larger dung pat formation is prevented and the area …

Vegetation Utilization And Dynamics In Hill Pastures Dominated By Calluna Or Agrostis-Festuca-Nardus And Grazed By Sheep Or Cattle, R Celaya, M Olivan, K Osoro

IGC Proceedings (1977-2023)

The dynamics of Agrostis-Festuca-Nardus. grasslands and Calluma heathlands with broom on plots with different ratio of area covered by each community type and grazed either by cattle or sheep were monitored during summers of 1990 and 1991. Significant differences were observed. Cattle grazed Nard11s more intensively than sheep and Cai tuna cover . was more, slrongly affected by cattle than sheep grazing. Brooms were grazed intensively by sheep but were rejected by cattle.

Diet Selection, Diet Quality, Dry Matter Intake And Growth Rate Of Cattle Grazing Tropical Grass-Legume, D B. Coates, A J. Ash, R W. Mclean

IGC Proceedings (1977-2023)

Dietary attributes and growth of cattle grazing tropical grass-legume pastures were ex.amined in 2 experiments in northern Queensland. Pastures oversown with legume gave substantial improvements in dietary ,nitrogen, digestibility and dry mauer intake compared with native 1rass pasture. On phosphorus (P)-deficient soils, applying P fertiliser or supplementing with P, improved P jntake, feed intake and growth rate of .cattle. Once nitrogen and P deficiencies were overcome, it was com:luded that diet digestibility was the main factor limiting the growth. of cattle and that the severity of this limitation was determined primarily by seasonal conditions.

Variation In Intake Rate And Mastication By Grazing Steers In The Spring, G P. Cosgrove, J C. Burns, D S. Fisher, K R. Pond, J P. Mueller

IGC Proceedings (1977-2023)

Changes in intake ,ate (IR), bite mass (BM), and biting rate (BR) and ingestive mastication of tall fescue (Festuca arundinacea Schrcb; TF), orchardgrass (Dactylis glomerata L; OG) and ryegrass (Lolium perenne L: RG) were studied over 3 grazings between early spring and early summer of 2 consecutive years. Defoliation by steers started at 100 mm canopy height (Tl) and terminated at 50 mm (T2). At Tl, and again at T2, ocsophageal-fistulated steers were used to estimate IR, BM and BR and to provide extrusa samples for determination of 1nasticatc particle size after dry sieving. At Tl there …

Varietal Differences In The Heifer Preference Of Orchardgrass, K Mizuno, S Shioya, F Fujimoto, M Kanbe

IGC Proceedings (1977-2023)

Heifer preferences of 14 varieties of orchardgrass (Dactylis glomerata L.) were studied using a tough cafeteria method throughout the growing season in 1991. Highly significant differences in heifer preferences between varieties were recognised through the 1st harvest in April to the 6th harvest in November. Several agronomic characters were negatively correlated with heifer preferences in each harvest: stage of maturity in the spring growth, occurrence of rhynchosporium scald (Rhynchosporium ortliosporum Caldwell) in the summer regrowth in July and of stem rust (Puccinia graminis Pers, f. sp. dactylitis Guyot and Massenot) in the autumn regrowth. However, leaf flexibility was …