Digital Commons Network^™

Sustainable Direction For Resource Management An Assessment Of The Regional Council Role, Allan Lohrey

IGC Proceedings (1977-2023)

The 1980s has seen an increased world awareness of the concept of sustainability. In 1991 New Zealand enacted the Resource Management Act (RMA) which reflected society's concern for a need to consider future generations when making decisions relating to the use of natural resources. Regional councils have been allocated the role within the Act to promote sustainable management at the regional level. The short term challenge to regional councils is to manage resources in manner which strikes a pragmatic balance between the ongoing needs of society and the need to provide resources for future generations. Regional councils will know they …

Application Of Dairy Manure On Alfalfa, Stephen J. Herbert, Jayarm Daliparthy, P L.M Veneman

IGC Proceedings (1977-2023)

Applying dairy manure to alfalfa (Medicago sativa L.) as ,in alternative 10 excess application to· corn (Zea mays L.) may reduce nitrate pollution of groundwater. Field experiments were conducted at 2 sites in Massachusetts, USA, lo study the impact or dairy manure application to alfalfa on forage yield, weed infestation· and nitrate movement. Treatments were an unfertilized (no N) check.· plot, low and high manure (112 and 336 kg N/ha/year equivalerit), and low and high N fertiliser (112 and 336 kg N/ha/year from NH4NO3),'. Liquid dairy manure was applied 10 • alfalfa immediately· after 1st· cutting during spring …

Lessons Learned From Developing Dashboards To Support Decision-Making For Community Opioid Response By Community Stakeholders: Mixed Methods And Multisite Study., Naleef Fareed, Ramona G. Olvera, Yiting Wang, Michael Hayes, Elizabeth Liz Larimore, Peter Balvanz, Ronald Langley, Corinna A. Noel, Peter J. Rock, Daniel Redmond, Jessica Neufeld, Sarah Kosakowski, Daniel R. Harris, Marc Larochelle, Timothy R. Huerta, Lashawn Glasgow, Emmanuel Oga, Jennifer Villani, Elwin Wu

Center on Drug and Alcohol Research Faculty Publications

BACKGROUND: Data dashboards are published tools that present visualizations; they are increasingly used to display data about behavioral health, social determinants of health, and chronic and infectious disease risks to inform or support public health endeavors. Dashboards can be an evidence-based approach used by communities to influence decision-making in health care for specific populations. Despite widespread use, evidence on how to best design and use dashboards in the public health realm is limited. There is also a notable dearth of studies that examine and document the complexity and heterogeneity of dashboards in community settings.

OBJECTIVE: Community stakeholders engaged in the …

Association Between Obesity And Risk Of Total And Obesity-Related Cancer In People With Incident Cardiovascular Disease., Sarah Malik, Avirup Guha, Xiaoling Wang, Neal L. Weintraub, Ryan Harris, Biplab Datta, Justin Moore, Priyanshu Nain, Sagar A. Patel, Steven Coughlin, Elizabeth Polter, Anna Prizment, Anne Blaes, Roberta Florido, Shelby Kutty, Alvaro Alonso, Corinne E. Joshu, Elizabeth A. Platz

Markey Cancer Center Faculty Publications

BACKGROUND: Cardiovascular disease (CVD) and cancer frequently co-occur due to shared risk factors such as obesity, which is linked to CVD and 14 cancer types. This study explores whether CVD pathophysiologies, combined with obesity, increase cancer risk, impacting clinical management.

METHODS AND RESULTS: Data from the ARIC (Atherosclerosis Risk in Communities) study, spanning 28 years, were analyzed. The cohort included 5127 participants with incident CVD (myocardial infarction, stroke, heart failure, coronary heart disease), of whom 1511 developed a first primary cancer. Follow-up began at CVD diagnosis after Visit 1. Obesity was assessed using body mass index, waist circumference, and waist-to-hip …

2024 Safety Belt Usage Survey In Kentucky, Erin Lammers-Staats, Derek Young, Kenneth R. Agent

Kentucky Transportation Center Research Report

No abstract provided.

Forage News [2024-09], University Of Kentucky

Forage News

No abstract provided.

Microfiltration Membrane Pore Functionalization With Primary And Quaternary Amines For Pfas Remediation: Capture, Regeneration, And Reuse, Sam Thompson, Angela Gutierrez, Jennifer Bukowski, Dibakar Bhattacharyya

UK CARES Faculty Publications

The widespread production and use of multi-fluorinated carbon-based substances for a variety of purposes has contributed to the contamination of the global water supply in recent decades. Conventional wastewater treatment can reduce contaminants to acceptable levels, but the concen- trated retentate stream is still a burden to the environment. A selective anion-exchange membrane capable of capture and controlled release could further concentrate necessary contaminants, mak- ing their eventual degradation or long-term storage easier. To this end, commercial microfiltration membranes were modified using pore functionalization to incorporate an anion-exchange moiety within the membrane matrix. This functionalization was performed with primary and …

Diabetes Screening Among Women With Polycystic Ovary Syndrome: A Descriptive Study Of Commercial Claims, 2011–2019, Jacklyn Vollmer, W. Jay Christian, Mary E. Lacy

UK CARES Faculty Publications

Background Polycystic ovary syndrome (PCOS) is a hormonal disorder that affects 6–12% of United States women of reproductive age. Because women with PCOS are at an increased risk of developing type 2 diabetes, clinical practice guidelines from a number of organizations (e.g. American Diabetes Association, American College of Obstetricians and Gynecologists, US Preventive Services Task Force) recommend that individuals with PCOS are routinely screened for diabetes. Guidelines further indicate that an oral glucose tolerance test (OGTT) should be used for diabetes screening in women with PCOS as opposed to an A1C or fasting plasma glucose test. The purpose of this …

Axonal Injury, Sleep Disturbances, And Memory Following Traumatic Brain Injury, Emma M. Tinney, Goretti España-Irla, Aaron E. L. Warren, Lauren N. Whitehurst, Alexandra N. Stillman, Charles H. Hillman, Timothy P. Morris, Alzheimer’S Disease Neuroimaging Initiative

Neurology Faculty Publications

Objectives: Traumatic brain injury (TBI) is associated with sleep deficits, but it is not clear why some report sleep disturbances and others do not. The objective of this study was to assess the associations between axonal injury, sleep, and memory in chronic and acute TBI. Methods: Data were acquired from two independent datasets which included 156 older adult veterans (69.8 years) from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) with prior moderate- to-severe TBIs and 90 (69.2 years) controls and 374 (39.6 years) from Transforming Research and Clinical Knowledge in TBI (TRACK-TBI) with a recent mild TBI (mTBI) and 87 controls …

Nitrate Removal By Floating Treatment Wetlands Under Aerated And Unaerated Conditions: Field And Laboratory Results, Jenna Mccoy, Matt Chaffee, Aaron Mittelstet, Tiffany L. Messer, Steve Comfort

Earth and Environmental Sciences Faculty Publications

Urban and storm water retention ponds eventually become eutrophic after years of receiving runoff water. In 2020, a novel biological and chemical treatment was initiated to remove accumulated nutrients from an urban retention pond that had severe algae and weed growth. Our approach installed two 6.1 m × 6.1 m floating treatment wetlands (FTWs) and two airlift pumps that contained slow-release lanthanum composites, which facilitated phosphate precipitation. Four years of treatment (2020–2023) resulted in median nitrate-N concentrations decreasing from 23 μg L−1 in 2020 to 1.3 μg L−1 in 2023, while PO4-P decreased from 42 μg L−1 to 19 μg …

Planetary Health Learning Objectives: Foundational Knowledge For Global Health Education In An Era Of Climate Change, Kathryn H. Jacobsen, Caryl E. Waggett, Pamela Berenbaum, Brett R. Bayles, Gail L. Carlson, René English, Carlos A Faerron Guzmán, Meredith L. Gartin, Liz Grant, Thomas L. Henshaw, Lora L. Iannotti, Philip J. Landrigan, Nina Lansbury, Hao Li, Maureen Y. Lichtveld, Ketrell Mcwhorter, Jessica E. Rettig, Cecilia J. Sorensen, Eric J. Wetzel, Dawn Michele Whitehead, Peter J. Winch, Keith Martin

Earth and Environmental Sciences Faculty Publications

Planetary health is an emerging field that emphasises that humans depend on a healthy Earth for survival and, conversely, that the sustainability of Earth systems is dependent on human behaviours. In response to member demands for resources to support teaching and learning related to planetary health, the Consortium of Universities for Global Health (CUGH) convened a working group to develop a set of planetary health learning objectives (PHLOs) that would complement the existing ten CUGH global health learning objectives. The eight PHLOs feature Earth system changes, planetary boundaries, and climate change science; ecological systems and One Health; human health outcomes; …

Coal Ash Triggers An Elevated Temperature Landfill Development: Lessons From The Bristol Virginia Solid Waste Landfill Neighboring Community, Reagan Patton Witt, Marcelo I. Guzman

UK CARES Faculty Publications

Landfills for disposing of solid waste are designed, located, managed, and monitored facili- ties expected to comply with government regulations to prevent contamination of the surrounding environment. After the average life expectancy of a typical landfill (30 to 50 years), a large investment in the construction, operation, final closure, and 30-year monitoring of a new site is needed. In this case study, we provide a holistic explanation of the unexpected development of elevated temperature landfills (ETLFs), such as that in the city of Bristol (United States) on the border of the states of Virginia and Tennessee, including the initial role …

Kentucky Surficial Geologic Map Compilation Database (Version 1), Matthew Massey

Research Data--KGS

The Kentucky Geological Survey (KGS), a state-supported independent research center within the University of Kentucky, is committed to providing accurate and unbiased geologic information on natural resources, environmental issues, and natural hazards in Kentucky. While Kentucky boasts complete coverage by 1:24,000-scale geologic bedrock maps, surficial materials have been largely overlooked, except in regions with thick deposits obscuring the bedrock. Given the increasing trends in economic development and urbanization, detailed surficial geologic mapping has become crucial for supporting geotechnical planning, environmental management, and hazard assessment. In response, KGS has prioritized new, detailed surficial geologic mapping since 2004, specifically targeting areas anticipated …

A Framework For Modeling The Impacts Of Adaptive Search Intensity On The Efficiency Of Abundance Surveys., Laura Jiménez, John R Fieberg, Michael Mccartney, Jake M Ferguson

Biology Faculty Publications

When planning abundance surveys, the impact of search intensity on the quality of the density estimates is rarely considered. We constructed a time-budget modeling framework for abundance surveys using principles from optimal foraging theory. We link search intensity to the number of sample units surveyed, searcher detection probability, the number of detections made, and the precision of the estimated population density. This framework allowed us to determine how a searcher should behave to produce optimized density estimates. Using data collected from quadrat and removal surveys of zebra mussels (Dreissena polymorpha) in central Minnesota, we applied this framework to evaluate potential …

Spot, Zone And Overcoat Painting Of Steel Bridges, Christopher Goff, Sudhir Palle

Kentucky Transportation Center Research Report

Over the past 25 – 30 years, the Kentucky Transportation Cabinet (KYTC) has replaced lead-based coatings on many bridges, often with zinc-based systems. But many of these coating systems are now degrading and reaching the ends of their service lives. Historically, KYTC has relied entirely on remove-and-replace painting, however, given the programmatic costs associated with remove-and-replace painting and constraints imposed by limited funding, the agency needs to explore more economical options, such as spot, zone, and overcoat painting. This report discusses use cases for spot, zone, and overcoat painting and lays out guidelines staff can use to determine what method …

China In Global Digital Trade Governance: Towards A Development-Oriented Agenda?, Yujia He, Ka Zeng

Patterson School of Diplomacy and International Commerce Faculty Publications

Existing literature on the behaviour of rising powers in global trade governance has yielded inconclusive evidence about their role and impact. This article contributes to this literature by examining China's role in global digital trade governance, an issue area which so far has not received sufficient scholarly attention. Specifically, it addresses the following question: as a self-proclaimed leader of the developing world in digital development, to what extent do its preferences and negotiation approach align with the interests of other developing countries? Analysing China's participation in three sets of negotiations using process tracing, the article argues that China's dual identity …

Predicting The Association Of Metabolites With Both Pathway Categories And Individual Pathways, Erik D. Huckvale, Hunter Moseley

Markey Cancer Center Faculty Publications

Metabolism is a network of chemical reactions that sustain cellular life. Parts of this metabolic network are defined as metabolic pathways containing specific biochemical reactions. Products and reactants of these reactions are called metabolites, which are associated with certain human-defined metabolic pathways. Metabolic knowledgebases, such as the Kyoto Encyclopedia of Gene and Genomes (KEGG) contain metabolites, reactions, and pathway annotations; however, such resources are incomplete due to current limits of metabolic knowledge. To fill in missing metabolite pathway annotations, past machine learning models showed some success at predicting the KEGG Level 2 pathway category involvement of metabolites based on their …

Perspectives On The Clinical Use Of Anti-Amyloid Therapy For The Treatment Of Alzheimer's Disease: Insights From The Fields Of Cancer, Rheumatology, And Neurology, Gregory Jicha, Erin Abner, Elif Pinar Coskun, Mark Huffmyer, Thomas Tucker, Peter T. Nelson

Neurology Faculty Publications

Introduction: The advent of disease-modifying therapies for Alzheimer’s disease (AD) has raised many questions and debates in the field as to the clinical benefits, risks, and costs of such therapies. The controversies have resulted in the perception that many clinicians are apprehensive about prescribing these medications to their patient populations. There also remains widespread uncertainty as to the economic impact, cost benefit ratio, and safety oversight for use of these medications in standard clinical care settings.

Methods: To contextualize such issues, the present study compared anti-amyloid biologic therapy (lecanemab) to four commonly used biologic agents in other fields, including trastuzumab …

Analysis Of The Thermal Aging Kinetics Of Tallow, Chicken Oil, Lard, And Sheep Oil, Yun-Chuan Hsieh, Hao Ouyang, Yulin Zhang, Donyau Chiang, Fuqian Yang, Hsin-Lung Chen, Sanboh Lee

Chemical and Materials Engineering Faculty Publications

Understanding the thermal aging kinetics of animal oils is of vital importance in the storage and applications of animal oils. In this work, we use four different techniques, including UV-Vis spectrometry, viscometry, impedance spectroscopy, and acid–base titration, to study the thermal aging kinetics of tallow, chicken oil, lard, and sheep oil in the temperature range from 120 ◦C to 180 ◦C. The evolutions of the UV-Vis absorbance, dynamic viscosity, electric impedance, and acid titration are discussed with the defect kinetics. The evolutions of the color centers, defects for dynamic viscosity, and electric dipoles follow second-order, first-order, and zero-order kinetics, respectively. …

The Seattle Amyotrophic Lateral Sclerosis (Als) Patient Project Database: Observational, Longitudinal, Dyadic Characterization Of People With Als And Their Partners, Suzanne C. Segerstrom, Edward J. Kasarskis

Neurology Faculty Publications

Introduction: The median survival time in ALS is approximately 3 years, but survival times range from less than a year to more than 10 years and much variance in disease course remains to be explained. As is true for physical outcomes, there is considerable variance in QOL, which is influenced by psychological health, coping, and social support, among other psychosocial factors. The Seattle ALS Patient Project Database (SALSPPD) provides a unique opportunity for researchers to address established and novel hypotheses about disease progression and QOL in ALS.

Methods: The SALSPPD is a longitudinal dataset of people with ALS (n = …

Medicare Medication Therapy Management, Ximena Oyarzún-González, Erin L. Abner, Patricia Freeman, Anna Kucharska-Newton, David W. Fardo, Daniela C. Moga

Biostatistics Faculty Publications

Background: The Medicare Medication Therapy Management (MTM) program has been available to eligible Medicare Part D beneficiaries since 2006, but research regarding program utilization and characterization is limited. Objective: To describe enrollee and MTM program characteristics in a national sample of Medicare fee-for-service (FFS) beneficiaries (2013 to 2016). Methods: Using a 5% random sample of Medicare FFS beneficiaries, we conducted a descriptive time series analysis to examine annual MTM enrollment and describe the type of MTM criteria at enrollment (Center for Medicare and Medicaid Services [CMS] vs. expanded). We investigated the offer of Comprehensive Medication Review (CMR) along with CMR …

Factors Associated With Child And Youth Mental Health Readmissions From A Us National Database, W. David Lohr, Kahir S. Jawad, Nichole Wood, Jennifer F. Le, Michelle D. Stevenson, Yana B. Feygin, Deborah Winders Davis

Biostatistics Faculty Publications

Objective: To describe and identify factors associated with mental health (MH) readmission rates for youth ages 5 to 17 years discharged between January 2019 and November 2019. Method: This retrospective, cross-sectional analysis using the 2019 Nationwide Readmissions Database identified hospitalizations for patients with a primary diagnosis of an MH condition using the Clinical Classification Software groupings, which are based on ICD-10-CM codes. Various patient characteristics including comorbidities were included in univariate and multivariate analysis to study their association with psychiatric readmission. Results: A 30-day readmission rate of 7.8% was found for the overall sample with significantly higher rates for youth …

Post Cardiac Arrest Left Ventricular Ejection Fraction Associated With Survival To Discharge, Kanjit Leungsuwan, Kory R. Heier, Olivia Henderson, Karam Ayoub, Talal Alnabelsi, Emily Slade, Vedant A. Gupta

Biostatistics Faculty Publications

Background: Post cardiac arrest left ventricular ejection fraction (LVEF) is routinely assessed, but the implications of this are unknown. This study aimed to assess the association between post cardiac arrest LVEF and survival to hospital discharge. Methods: In this retrospective cohort study, all in-hospital and out of hospital cardiac arrests at our tertiary care center between January 2012 and September 2015 were included. Baseline demographics, clinical data, characteristics of the arrest, and interventions performed were collected. Earliest post cardiac arrest echocardiograms were reviewed with LVEF documented. The primary outcome was survival to discharge. Results: A total of 736 patients were …

Regenerating Family Member 3 Alpha Is Predictive Of Mortality Following Emergent Large Vessel Occlusion, Madison Sands, Christopher J. Mclouth, Jacqueline A. Frank, Benton Maglinger, Nathan Millson, Mais N. Al-Kawaz, Shivani Pahwa, David L. Dornbos, Douglas E. Lukins, Amanda L. Trout, Ann M. Stowe, Justin F. Fraser, Keith R. Pennypacker

Biostatistics Faculty Publications

Regenerating Family Member 3 Alpha (REG3A) is an antimicrobial protein secreted by the intestine and pancreas with additional immunomodulatory properties. Previously, we published that REG3A expression in ischemic stroke patient systemic blood, during mechanical thrombectomy (MT), is significantly associated with inflammatory cytokines and patient function on admission. This paper, however, did not investigate post-acute death rates. Therefore, we investigated plasma REG3A protein expression, during MT, in patients (n = 141) that survived or died within the end of the follow-up after MT. Subjects who died had significantly higher systemic plasma REG3A levels at the time of MT compared to survivors …

Enhancement Of High-Density Lipoprotein-Associated Protease Inhibitor Activity Prevents Atherosclerosis Progression, Maura Mobilia, Alexander A. Karakashian, Khaga R. Neupane, Olivia Hage, Callie Whitus, Abigail Carter, Clairity Voy, Lance A. Johnson, Gregory A. Graf, Scott M. Gordon

Saha Cardiovascular Research Center Faculty Publications

Background and aims: Inflammatory cells within atherosclerotic lesions secrete proteolytic enzymes that contribute to lesion progression and destabilization, increasing the risk for an acute cardiovascular event. Elastase is a serine protease, secreted by macrophages and neutrophils, that may contribute to the development of unstable plaque. We previously reported interaction of endogenous protease-inhibitor proteins with high- density lipoprotein (HDL), including alpha-1-antitrypsin, an inhibitor of elastase. These findings support a potential role for HDL as a modulator of protease activity. In this study, we test the hypothesis that enhancement of HDL-associated elastase inhibitor activity is protective against atherosclerotic lesion progression.

Methods: We …

Checklist And Key To Species Of Stink Bugs (Hemiptera, Heteroptera, Pentatomidae) Of Kentucky, United States Of America, Armando Falcon-Brindis, Raul Villanueva

Entomology Faculty Publications

Stink bugs (Heteroptera: Pentatomidae) have received a lot of attention as there are many economically important pest species. However, the status of species richness, distribution, and taxonomy remain overlooked and outdated in Kentucky (USA). Having such information at a regional scale is crucial to allow the development of suitable pest management and conservation programs. Here, the stink bug fauna of Kentucky was ex- amined from museum specimens, literature, and public online repositories. Overall, 42 species in 28 genera and three subfamilies (Asopinae, Podopinae, and Pentatominae) are listed from Kentucky. Thirteen species are new records for Kentucky, 10 species are considered …

Deciphering Cellular Heterogeneity In Spodoptera Frugiperda Midgut Cell Line Through Single Cell Rna Sequencing, Surjeet Kumar Arya, Douglas A. Harrison, Subba R. Palli

Entomology Faculty Publications

Using the 10x Genomics Chromium single-cell RNA sequencing (scRNA-seq) platform, we discovered unexpected heterogeneity in an established cell line developed from the midgut of the Fall armyworm, Spodoptera frugiperda, a major global pest. We analyzed the sequences of 18,794 cells and identified ten unique cellular clusters, including stem cells, enteroblasts, enterocytes and enteroendocrine cells, characterized by the expression of specific marker genes. Additionally, these studies addressed an important knowledge gap by investigating the expression of genes coding for respiratory and midgut membrane insecticide targets classified by the Insecticide Resistance Action Committee. Dual-fluorescence tagging method, fluorescence microscopy and fluorescence- activated cell …

Hemp Regulates The Fitness Of Corn Earworm (Lepidoptera, Noctuidae) And Its Tachinid (Diptera) Parasitoids, Armando Falcon-Brindis, Raul Villanueva

Entomology Faculty Publications

Pest management on hemp is still in its infancy, and biological control options are limited. Helicoverpa zea (corn earworm) is one of the key pests of hemp cultivated outdoors, especially on cultivars grown for cannabinoids and grain. In a three-year study, we assessed the effect of diet on the performance of H. zea and its tachinid parasitoids. Parasitized (bearing fly eggs) and unparasitized (without eggs) H. zea larvae were fed on hemp flowers or an artificial diet. Five tachinid species parasitized H. zea larvae, but the most abundant species were Winthemia rufopicta (68.8%) and Lespesia aletiae (28.3%). Overall, 55.2% of …

Growth And Faceting Of Tungsten And Oxides In Scandate Cathode Particles During In Situ Heating In The Scanning Electron Microscope, Huanhuan Bai, Thomas John Balk

Chemical and Materials Engineering Faculty Publications

Tungsten-based scandate dispenser cathodes are promising next-generation thermionic electron sources for vacuum electron devices, due to their excellent emission performance at tempera- tures lower than those required for conventional cathodes. There has been a significant recent effort to understand scandate cathode performance and to characterize the tungsten and other materials on the emitting surface, primarily via the study of cathodes before and after emission testing. Moreover, these scandate cathodes have typically been characterized at room temperature only. In situ obser- vations of scandate cathodes is challenging, as these devices are thermionic emitters that operate in a high-vacuum environment, and because …

Effects Of External Pressure On Cycling Performance Of Silicon-Based Lithium-Ion Battery: Modelling And Experimental Validation, Kai Zhang, Yinan He, Junwu Zhou, Xinyang Wang, Yong Li, Fuqian Yang

Chemical and Materials Engineering Faculty Publications

Controlling the stress state of electrodes during electrochemical cycling can have a positive effect on the cycling performance of lithium-ion battery. In this work, we study the cycling performance of silicon-based lithium-ion half cells under the action of pressure in a range of 0.1 to 0.4 MPa. The cycling performance of the silicon-based lithium-ion half cells increases first with increasing the pressure to 0.2 MPa and then decreases with further increasing the pressure. The analysis of the surface morphologies of cycled electrodes reveals that applying a pressure of 0.2 MPa leads to the formation of fine electrode surface with the …