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Variation Of Seed Yield And Its Components In Common Vetch (Vicia Sativa L.) Under Different Conditions, E Acikgoz, I Turgut, H Ekiz Apr 2025

Variation Of Seed Yield And Its Components In Common Vetch (Vicia Sativa L.) Under Different Conditions, E Acikgoz, I Turgut, H Ekiz

IGC Proceedings (1977-2023)

Common vetch (Vicia sativa L.) is widely used as a seed or hay crop in Turkey. In humid coastal areas it is principally used fot hay or green herbage while in dry regions it is used mostly for seed. Roughly ground vetch seed is a popular concentrated feed and mixed with straw or cereal grain (A9ikg6z, 1988). Approximately 200.000 ha of common vetch are seeded every year in Turkey. It is sown mostly as a spring-seeded crop and is often subjected to severe heat and drought stress as the season progress. Yields are generally low with an average seed …

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White Clover Seed Production In Two Mediterranean Environments Of Tuscany And Sardinia, P Bullitta, Simonetta Bullitta, A Pardini, S Piemontese, P P. Roggero, P Talamucci Apr 2025

White Clover Seed Production In Two Mediterranean Environments Of Tuscany And Sardinia, P Bullitta, Simonetta Bullitta, A Pardini, S Piemontese, P P. Roggero, P Talamucci

IGC Proceedings (1977-2023)

Purpose of the trialwas the identification of the most suitable varieties for white clover Trifolium repens L. seed production in Mediterranean environments. The main reason of this paper is to verify whether it is possible to produce seed of European varieties of white clover in south Europe considering that surfaces for seed production are decreasing in the northern European countries that were normally producers of white clo­ver seed. The production of clover seed in southern Europe could advantageously replace the import from New Zealand and California.

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Vegetative Propagation Of White Clover An Application In White Clover Seed Production, P C.D Newton, A I. Popay Apr 2025

Vegetative Propagation Of White Clover An Application In White Clover Seed Production, P C.D Newton, A I. Popay

IGC Proceedings (1977-2023)

Establishment of white clover for agricultural purposes is invariably by seed. However, natural regeneration is almost entirely vegetative (Chapman, 1987), and flowering may be restricted to a small proportion of individuals within a popu­lation (Burdon, 1980) When white clover is present in the soil seedbank, there is potential for both intra- (between classes) and inter-varietal contamination of seed crops. Lancashire et al., (1985) have commented that genetic contamination of white clover seed is a world-wide problem. Volunteer seedlings may be removed from between the crop rows mechanically, but there remains an untreatable area close to the crop which is available …

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Viability Of Stylosanthes Seeds As Affected By Storage Duration, J B. Brolmann, B J. Boman Apr 2025

Viability Of Stylosanthes Seeds As Affected By Storage Duration, J B. Brolmann, B J. Boman

IGC Proceedings (1977-2023)

Tropical legumes such as members of the genus Stylosanthes (sty lo) contribute to the improvement of pastures in the tropics and sub-tropics. Stylosanthes is usually established from seed. In Florida, seed of Stylosanthes has to be produced and col­lected before the onset of the winter since occasional frosts can damage seed-bearing vegetation. Therefore, early maturing Stylosanthes varieties have been developed. In stylo seed collections maintained for breeding or seed exchange purposes, maintenances of seed viability is critical. New pests or new diseases may require a renewed screening of stored accessions. It is important, then, that the seed source of this …

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Modification Of Stolon Growth, Development And Flowering By Plant Growth Regulators In White Clover (Trifolium Repens L.) Seed Crops, A H. Marshall, D H. Hides Apr 2025

Modification Of Stolon Growth, Development And Flowering By Plant Growth Regulators In White Clover (Trifolium Repens L.) Seed Crops, A H. Marshall, D H. Hides

IGC Proceedings (1977-2023)

Within the EEC the need to develop low cost less intensive systems of animal production has led to an increase in the importance of legumes generally, and white clover in particu­lar. At present, annual white clover seed usage within the EEC is approximately 4,000 tonnes, however, the self sufficiency rate is expected to fall below 50 % by the end of the 1980s due prin­cipally to unpredictable seed yields which make it an unprofit­able crop for seed growers. The main component of seed yield in white clover is the number of ripe inflorescences at harvest (Zaleski, 1961) however, the proportion …

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Growth Regulator Effects On Seed Production Of Lotus Corniculatus L. And Lotus Uliginosus Schkuhr., J G. Hampton, Qingfeng Li, M D. Hare Apr 2025

Growth Regulator Effects On Seed Production Of Lotus Corniculatus L. And Lotus Uliginosus Schkuhr., J G. Hampton, Qingfeng Li, M D. Hare

IGC Proceedings (1977-2023)

Seed yield in both Lotus corniculatus L. and Lotus uliginosus Schkuhr. (syn. L. pedunculatus Cav.) is considered to be limited by the indeterminate growth habit which results in a protracted (2-4 month) flowering period (Witchwoot, 1987; Li and Hill, 1988) leading to wide variation in seed maturity and seed loss through pod shattering. In both species seed yield is determined primarily by the number of inflorescences (Mos, 1983 ; Wit­chwoot, 1987), and thus treatments which alter or remove api­cal dominance, enhance shoot production or main stem bran­ching thereby increasing inflorescence numbers (Clifford et al., 1983 ; Li and Hill, 1988), …

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Plant Resources And Forage Seed Production In China, Dong Peihua Apr 2025

Plant Resources And Forage Seed Production In China, Dong Peihua

IGC Proceedings (1977-2023)

China is situated in the Eastern part of Asia ; from North to South it extends across the temperate and tropical zones. From East to West it has humid, semiarid, arid regions. There is no frost through the year in some part ofHainan Island, Yunnan, Guangdong and Taiwan provinces. Therefore plants grow the year round and there is a wide range of tropical species. The geographical and climatical differences resulted in rich grass resources. There are three hundred million hectares of natural pastures in Northern China, with more than 4000 plant species. These plants have different degrees of feeding value. …

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Consumer Perceptions Of Hemp-Fed Aquaculture, Jillian Hyink, Brandon R. Mcfadden, Saroj Adhikari, Brandy E. Phipps, Tyler Mark, Waldemar Rossi, Craig Schluttenhofer, Seong D. Yun Apr 2025

Consumer Perceptions Of Hemp-Fed Aquaculture, Jillian Hyink, Brandon R. Mcfadden, Saroj Adhikari, Brandy E. Phipps, Tyler Mark, Waldemar Rossi, Craig Schluttenhofer, Seong D. Yun

Agricultural Economics Faculty Publications

Global demand for seafood has increased significantly in recent decades and is projected to continue rising. Aquaculture production has increased in the United States and globally to meet this demand, offering a relatively sustainable supplement to wild fish supplies. However, increased production further strains natural populations of pelagic species used to make fishmeal and fish oil into feedstocks, raising production costs and introducing safety concerns associated with fish consumption. A potential alternative feed ingredient is hemp, which can provide a cost-effective and nutritious feed for carnivorous fish. Moreover, hemp could meet the requirements for the final product to carry a …

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Tolerance Of Homonegativity And Transnegativity Predicts Negative Evaluations Of Lgbt People And Lgbt-Supportive Policies Among Us-Based Heterosexual, Cisgender Participants, Abigail M. Folberg, Jennifer S. Hunt, Ellen D. B. Riggle Apr 2025

Tolerance Of Homonegativity And Transnegativity Predicts Negative Evaluations Of Lgbt People And Lgbt-Supportive Policies Among Us-Based Heterosexual, Cisgender Participants, Abigail M. Folberg, Jennifer S. Hunt, Ellen D. B. Riggle

Gender and Women's Studies Faculty Publications

Many people in the United States express anti-LGBT attitudes and oppose LGBT rights. These views are perpetuated when others, including allies, tolerate expressions of anti-LGBT bias. In this study, we adapted and validated a measure of tolerance of homonegativity and transnegativity (TOHT), and assessed its associations with evaluations of LGBT people, straight people, support for LGBT rights, and system-justifying ideologies among heterosexual, straight, binary-gendered/non-trans (i.e., cisgender) women and men who identified as liberal, moderate, or conservative (N = 295). Participants completed measures of TOHT, evaluations of LGBT people, support for LGBT rights, authoritarianism, religiosity, and contact with LGBT people. Analyses …

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Smart Home Hvac Digital Twin Ml Meta-Model For Electric Power Distribution Systems With Solar Pv And Cta-2045 Controls, Rosemary E. Alden, Evan S. Jones, Steven B. Poore, Dan M. Ionel Apr 2025

Smart Home Hvac Digital Twin Ml Meta-Model For Electric Power Distribution Systems With Solar Pv And Cta-2045 Controls, Rosemary E. Alden, Evan S. Jones, Steven B. Poore, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

Building modeling, specifically heating, ventilation, and air conditioning (HVAC) load and equivalent energy storage calculations, represent a key focus for decarbonization of buildings and smart grid controls. In this paper, an ultra-fast one minute resolution Hybrid Machine Learning Model (HMLM) is proposed as part of a novel contribution in the field of residential physics-based smart home surrogate modeling. Emulation of white box models, or digital twins, with editable parameters through machine learning (ML) meta-modeling serves as an alternative to wide-spread experimental big data collection. The HMLM employs combined k-means clustering with multiple linear regression (MLR) to emulate minutely HVAC power …

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Novel Approaches To Analyze Consumer Behavior And Policies To Promote Sustainable Consumption, Bhagyashree Katare, Xuejian Wang, Shuoli Zhao, Jacqueline Yenerall Apr 2025

Novel Approaches To Analyze Consumer Behavior And Policies To Promote Sustainable Consumption, Bhagyashree Katare, Xuejian Wang, Shuoli Zhao, Jacqueline Yenerall

Agricultural Economics Faculty Publications

Technological advancements, such as online grocery shopping, have significantly transformed consumer retail environments and experiences. Effectively studying consumer behavior in these new environments requires the use of novel methodological approaches, which will also aid in developing interventions to encourage sustainable consumption. This paper begins by providing an overview of the current literature on novel approaches to analyzing consumer behavior, then provides an empirical application by examining consumer decision-making pathways within an online grocery shopping platform. Specifically, the paper focuses on exploring the consumers’ digital footprints, such as page visits, product additions and removals, and interactions with information labels to identify …

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Candidates Be Posting, Josephine Lukito, Maggie Macdonald, Bin Chen, Megan A. Brown, Stephen Prochaska, Yunkang Yang, Jason Greenfield, Jiyoun Suk, Wei Zhong, Ross Dahlke, Porismita Borah Apr 2025

Candidates Be Posting, Josephine Lukito, Maggie Macdonald, Bin Chen, Megan A. Brown, Stephen Prochaska, Yunkang Yang, Jason Greenfield, Jiyoun Suk, Wei Zhong, Ross Dahlke, Porismita Borah

Political Science Faculty Publications

In this multi-platform, comparative study, we analyze social media messages from political candidates (N = 1,517) running for Congress during the 2022 U.S. Midterm election. We collect data from seven social media platforms: Facebook, Twitter, Truth Social, Gettr, Instagram, YouTube, and Rumble over the 4 weeks before and after election day. With this unique dataset of posts, we apply computational methods to identify messages that sought to mobilize individuals (online and offline) to donate money, vote, attend events, engage with the campaign online, and visit the campaign’s content on other platforms. We find that Democrats were not on alt-tech platforms …

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The Price Of Justice, Jillienne Haglund, Francesca Parente Apr 2025

The Price Of Justice, Jillienne Haglund, Francesca Parente

Political Science Faculty Publications

What factors explain compliance with monetary damages awarded by the Inter-American Court of Human Rights (IACtHR)? States comply with the payment of monetary damages at higher rates than other forms of reparation. However, the higher compliance rate belies the significant variation in time to compliance with the payment of monetary awards. We identify three case-level characteristics that explain this variation: size of awards, number of victims, and victim identity. We test our hypotheses utilizing original datasets on compliance with monetary damages and case characteristics in IACtHR judgments through 2019, and find support for all three factors on time to compliance.

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B Cells Upregulate Nmdars, Respond To Extracellular Glutamate, And Express Mature Bdnf To Protect The Brain From Ischemic Injury, Vanessa O. Torres, Jadwiga Turchan-Cholewo, Mary K. Colson, Pavel Yanev, Daimen R.S. Britsch, Katherine M. Cotter, Annabel M. Mcatee, Thomas A. Ujas, Domenico Mercurio, Xiangmei Kong, Erik J. Plautz, Chaitanya R. Joshi, Takeshi K. Matsui, Eiichiro Mori, Ambar Cajigas-Hernandez, Kielen Zuurbier, Steven Estus, Mark P. Goldberg, Nancy L. Monson, Ann M. Stowe Apr 2025

B Cells Upregulate Nmdars, Respond To Extracellular Glutamate, And Express Mature Bdnf To Protect The Brain From Ischemic Injury, Vanessa O. Torres, Jadwiga Turchan-Cholewo, Mary K. Colson, Pavel Yanev, Daimen R.S. Britsch, Katherine M. Cotter, Annabel M. Mcatee, Thomas A. Ujas, Domenico Mercurio, Xiangmei Kong, Erik J. Plautz, Chaitanya R. Joshi, Takeshi K. Matsui, Eiichiro Mori, Ambar Cajigas-Hernandez, Kielen Zuurbier, Steven Estus, Mark P. Goldberg, Nancy L. Monson, Ann M. Stowe

Physiology Faculty Publications

Following stroke, B cells enter brain regions outside of the ischemic injury to mediate functional recovery. Although B cells produce neurotrophins that support remote plasticity, including brain-derived neurotrophic factor (BDNF), it remains unclear which signal(s) activate B cells in the absence of infarct-localized pro-inflammatory cues. Activation of N-methyl-D-aspartate (NMDA)-type receptor (NMDAR) subunits on neurons can upregulate mature BDNF (mBDNF) production from a pro-BDNF precursor, but whether this occurs in B cells is unknown. We identified GluN2A and GluN2B NMDAR subunits on B cells that respond to glutamate and mediate nearly half of the glutamate-induced Ca2+ responses in activated B …

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The Acth Test Fails To Diagnose Adrenal Insufficiency And Augments Cytokine Production In Sepsis, Dan Hao, Qian Wang, Misa Ito, Jianyao Xue, Ling Guo, Bin Huang, Chieko Mineo, Philip W. Shaul, Xiang An Li Apr 2025

The Acth Test Fails To Diagnose Adrenal Insufficiency And Augments Cytokine Production In Sepsis, Dan Hao, Qian Wang, Misa Ito, Jianyao Xue, Ling Guo, Bin Huang, Chieko Mineo, Philip W. Shaul, Xiang An Li

Physiology Faculty Publications

The adrenocorticotropic hormone (ACTH) test diagnoses relative adrenal insufficiency (RAI) or critical illness–related corticosteroid insufficiency (CIRCI). Initially, guidelines recommended corticosteroid/glucocorticoid (GC) therapy for septic patients with RAI, but later trials did not show a survival benefit, leading to updated guidelines that abandon targeting RAI or CIRCI. Recent studies with an RAI mouse model showed a clear survival benefit from GC therapy in mice with RAI, suggesting that inconclusive GC clinical trials might be due to issues with the ACTH test rather than targeting RAI. To investigate, we performed the ACTH test in septic mice. Interestingly, the ACTH test identified most …

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Steroid Receptors And Coregulators: Dissemination Of Sex Differences And Emerging Technologies, Sally Pauss, Evelyn A. Bates, Genesee J. Martinez, Zane T. Bates, Zachary A. Kipp, Cassandra D. Gipson, Terry D. Hinds Jr. Apr 2025

Steroid Receptors And Coregulators: Dissemination Of Sex Differences And Emerging Technologies, Sally Pauss, Evelyn A. Bates, Genesee J. Martinez, Zane T. Bates, Zachary A. Kipp, Cassandra D. Gipson, Terry D. Hinds Jr.

Markey Cancer Center Faculty Publications

Steroid receptors are ligand-induced transcription factors that have broad functions among all living animal species, ranging from control of sex differences, body weight, stress responses, and many others. Their binding to coregulator proteins is regulated by corepressors and coactivators that interchange upon stimulation with a ligand. Coregulator proteins are an imperative and understudied aspect of steroid receptor signaling. Here, we discuss steroid receptor basics from protein domain structures that allow them to interact with coregulators and other proteins, their essential functions as transcription factors, and other elemental protein–protein interactions. We deliberate about the mechanisms that coregulators control in steroid receptor …

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Lysyl Hydroxylase 2 Glucosylates Collagen Vi To Drive Lung Cancer Progression, Shike Wang, Houfu Guo, Reo Fukushima, Masahiko Terajima, Min Liu, Guan-Yu Xiao, Lenka Koudelková, Chao Wu, Xin Liu, Jiang Yu, Emma Burris, Jun Xu, Alvise Schiavinato, William K. Russell, Mitsuo Yamauchi, Xiaochao Tan Apr 2025

Lysyl Hydroxylase 2 Glucosylates Collagen Vi To Drive Lung Cancer Progression, Shike Wang, Houfu Guo, Reo Fukushima, Masahiko Terajima, Min Liu, Guan-Yu Xiao, Lenka Koudelková, Chao Wu, Xin Liu, Jiang Yu, Emma Burris, Jun Xu, Alvise Schiavinato, William K. Russell, Mitsuo Yamauchi, Xiaochao Tan

Markey Cancer Center Faculty Publications

Lysyl hydroxylase 2 (LH2) is highly expressed in multiple tumor types and accelerates disease progression by hydroxylating lysine residues on fibrillar collagen telopeptides to generate stable collagen cross links in tumor stroma. Here, we show that a galactosylhydroxylysyl glucosyltransferase (GGT) domain on LH2 modified type-VI collagen (Col6) to promote lung adenocarcinoma (LUAD) growth and metastasis. In tumors generated by LUAD cells lacking LH2 GGT domain activity, stroma was less stiff, and stable types of collagen cross links were reduced. Mass spectrometric analysis of total and glycosylated peptides in parental and GGT-inactive tumor samples identified Col6 chain α3 (Col6a3), a component …

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Mo-Substitution In V2O5 Tunes The Structure Towards Three-Dimensional Connectivity And Improves Li-Ion Battery Cycling, Kausturi Parui, Bonnie G. Gardner, Kathryn A. Pitton, Noah G. Caracuel, Emily Vidal-Torres, Shornam Gandhi, Beth S. Guiton, Juan C. Nino, Megan M. Butala Apr 2025

Mo-Substitution In V2O5 Tunes The Structure Towards Three-Dimensional Connectivity And Improves Li-Ion Battery Cycling, Kausturi Parui, Bonnie G. Gardner, Kathryn A. Pitton, Noah G. Caracuel, Emily Vidal-Torres, Shornam Gandhi, Beth S. Guiton, Juan C. Nino, Megan M. Butala

Chemistry Faculty Publications

The development of alternative energy sources is crucial for reducing reliance on fossil fuels, particularly for mobile applications such as personal electronics and transportation. This necessitates the advancement of battery materials based on abundant and inexpensive constituent elements. To achieve this requires investigating materials in a broader compositional and structural design space. Early transition metal oxides, including the intercalation electrode α − V2O5, however, the performance of V2O5 is hindered by phase transformations during battery cycling that lead to capacity fade and short device lifetimes. This study investigates the modification of V2 …

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Management Of Cardiovascular Implantable Electronic Device Infection Utilizing A Multidisciplinary Team, Evan Hall, Bennett Collis, Talal Alnabelsi, Chloe Cao, Meredith Johnson, John Gurley, Luke Strnad, Hassan Reda, Tessa London, Erinn Ogburn, Michael Sekela, Bobbi Jo Stoner, Sami El-Dalati Apr 2025

Management Of Cardiovascular Implantable Electronic Device Infection Utilizing A Multidisciplinary Team, Evan Hall, Bennett Collis, Talal Alnabelsi, Chloe Cao, Meredith Johnson, John Gurley, Luke Strnad, Hassan Reda, Tessa London, Erinn Ogburn, Michael Sekela, Bobbi Jo Stoner, Sami El-Dalati

Surgery Faculty Publications

Background. Significant numbers of cardiac implantable electronic devices are placed in the United States, and infection can be a severe consequence of implantation. Despite guideline recommendations and data demonstrating that lead extraction improves mortality for patients with device infection, rates of lead removal are lower than guideline recommendations. We report the outcomes associated with management of suspected cardiac implantable electronic device infections by a multidisciplinary team. Methods. Patient cases were identified from an institutional multidisciplinary endocarditis team registry in a single-center retrospective study. Demographic, treatment, and outcomes data were recorded by study investigators. Results. Between September 7, 2021, and February …

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The Role Of Race/Ethnicity On The Association Between Neighborhood Deprivation And Breast Cancer Outcomes Among Kentucky Patients With Breast Cancer (2010–2022), Breyanna Walker, Elinita Pollard, Sydney P. Howard, V. Morgan Jones, Kathleen L. O’Connor, Eric B. Durbin, Pamela C. Hull, Samantha R. Jones, Adebola Adegboyega, Xiaoqin Wang, Wendi A.B. Owen, Margaret M. Szabunio, Lovoria B. Williams, Justin X. Moore Apr 2025

The Role Of Race/Ethnicity On The Association Between Neighborhood Deprivation And Breast Cancer Outcomes Among Kentucky Patients With Breast Cancer (2010–2022), Breyanna Walker, Elinita Pollard, Sydney P. Howard, V. Morgan Jones, Kathleen L. O’Connor, Eric B. Durbin, Pamela C. Hull, Samantha R. Jones, Adebola Adegboyega, Xiaoqin Wang, Wendi A.B. Owen, Margaret M. Szabunio, Lovoria B. Williams, Justin X. Moore

Surgery Faculty Publications

Background: Kentucky is within the top five leading states for breast cancer mortality nationwide. This study investigates the association between neighborhood socioeconomic disadvantage and breast cancer outcomes, including surgical treatment, radiotherapy, chemotherapy, and survival, and how associations vary by race and ethnicity in Kentucky. Methods: We conducted a retrospective cohort analysis using data from the Kentucky Cancer Registry for patients with breast cancer diagnosed between 2010 and 2017, with follow-up through December 31, 2022. We linked Kentucky Cancer Registry data with census tract data to examine the relationship between area deprivation index (ADI) and breast cancer outcomes. Logistic regression and …

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Characterization Of Tnsalp Expression And Activity In Porcine Utero-Placental Tissues, Claire Stenhouse, Nirvay Sah, Katherine M. Halloran, Robyn M. Moses, Makenzie G. Newton, Joe W. Cain, Heewon Seo, Guoyao Wu, Gregory A. Johnson, Fuller W. Bazer Apr 2025

Characterization Of Tnsalp Expression And Activity In Porcine Utero-Placental Tissues, Claire Stenhouse, Nirvay Sah, Katherine M. Halloran, Robyn M. Moses, Makenzie G. Newton, Joe W. Cain, Heewon Seo, Guoyao Wu, Gregory A. Johnson, Fuller W. Bazer

Animal and Food Sciences Faculty Publications

Abstract: Tissue non-specific alkaline phosphatase (TNSALP) regulates postnatal phosphate homeostasis, but its role in utero-placental phosphate availability remains poorly understood. Gilts were bred and hysterectomized on Day 60 or Day 90 of gestation (n = 6/day). Phosphate was less abundant in allantoic and amniotic fluids on Day 90 compared to Day 60. TNSALP protein was immunolocalized, and enzymatic activity was quantified and localized in endometrial and chorioallantois tissues. Day had no effect on TNSALP activity in the chorioallantois. In contrast, endometrial TNSALP activity was lower on Day 90 compared to Day 60. Phosphate abundance in allantoic fluid correlated positively with …

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Separation And Quantification Of Mycotoxins In Floral Tissue Of Hemp (Cannabis Sativa) Infected With Fusarium Graminearum, Isabelle A. Kagan, Henry S. Smith, Rachel R. Schendel, Nicole Gauthier Apr 2025

Separation And Quantification Of Mycotoxins In Floral Tissue Of Hemp (Cannabis Sativa) Infected With Fusarium Graminearum, Isabelle A. Kagan, Henry S. Smith, Rachel R. Schendel, Nicole Gauthier

Animal and Food Sciences Faculty Publications

Background: The fungal pathogen Fusarium graminearum produces mycotoxins when it infects grains. This pathogen also infects hemp (Cannabis sativa L. containing less than 0.3% tetrahydrocannabinol or THC). The presence of trichothecene mycotoxins like deoxynivalenol (DON) has not been reported in floral tissue of hemp infected with F. graminearum. The object of this study was to develop a method to extract three trichothecene mycotoxins—DON, 3-acetyldeoxynivalenol (3-ADON), and 15-acetyldeoxynivalenol (15-ADON)—from hemp floral tissue, and to quantify the mycotoxins by high-performance liquid chromatography (HPLC) with ultraviolet detection. Results: Standards of nivalenol (NIV), DON-3-glucoside (D3G), DON, 3-ADON, and 15-ADON were separated from each other …

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Clustering Individuals Using Inmtd, Zuqi Li, Sam F.L. Windels, Noël Malod-Dognin, Seth M. Weinberg, Mary L. Marazita, Susan Walsh, Mark D. Shriver, David W. Fardo, Peter Claes, Nataša Przulj, Kristel Van Steen Apr 2025

Clustering Individuals Using Inmtd, Zuqi Li, Sam F.L. Windels, Noël Malod-Dognin, Seth M. Weinberg, Mary L. Marazita, Susan Walsh, Mark D. Shriver, David W. Fardo, Peter Claes, Nataša Przulj, Kristel Van Steen

Biostatistics Faculty Publications

Motivation: Combining omics and images can lead to a more comprehensive clustering of individuals than classic single-view approaches. Among the various approaches for multi-view clustering, nonnegative matrix tri-factorization (NMTF) and nonnegative Tucker decomposition (NTD) are advantageous in learning low-rank embeddings with promising interpretability. Besides, there is a need to handle unwanted drivers of clusterings (i.e. confounders). Results: In this work, we introduce a novel multi-view clustering method based on NMTF and NTD, named INMTD, which integrates omics and 3D imaging data to derive unconfounded subgroups of individuals. According to the adjusted Rand index, INMTD outperformed other clustering methods on a …

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Nicotine Promotes Angii-Induced Abdominal Aortic Aortopathies In Female And Male Mice, Mark Ensor, Sean E. Thatcher, Kristen Mcquerry, Kory Heier, Heba M. Ali, Victoria English, Lisa A. Cassis, Yasir Alsiraj Apr 2025

Nicotine Promotes Angii-Induced Abdominal Aortic Aortopathies In Female And Male Mice, Mark Ensor, Sean E. Thatcher, Kristen Mcquerry, Kory Heier, Heba M. Ali, Victoria English, Lisa A. Cassis, Yasir Alsiraj

Biostatistics Faculty Publications

Cigarette smoking is a risk factor for abdominal aortic aneurysms (AAAs), with studies suggesting a higher smoking-related AAA risk in women than men. We examined nicotine’s effects on angiotensin II (AngII)-induced AAAs in male and female low-density lipoprotein receptor-deficient (Ldlr-/-) mice. Moreover, we defined effects of gonadectomy (GDX) of both sexes on nicotine-induced regulation of AAAs. Male and female Ldlr-/- mice (8–12 weeks of age) were infused with AngII with or without nicotine. Mice underwent sham or GDX surgeries prior to infusions of AngII and nicotine. In males, one or both testes were removed. AAA incidence, size, …

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Harvest Management And Regrowth Of Trifolium Alexandrinum, R E. Joost, J D. Mooso Mar 2025

Harvest Management And Regrowth Of Trifolium Alexandrinum, R E. Joost, J D. Mooso

IGC Proceedings (1977-2023)

Adaptation of berseem clover (Trifolium alexandrinum) beyond the coastal regions of the southeastern United States was limited by a lack of cold tolerance prior to the release of 'Bigbee', a selection from a stand of 'Sacromonte' subjected to temperature of -15 and -18 Con successive nights in 1972. The release of Bigbee in 1985 expanded the range of berseem clover adaptation to include the entire Southeast, as far north as Oklahoma (Knight, 1985). It is known that annual clovers do not rely on root reserve carbohydrates, but rather on residual leaf area and rapid leaf regeneration from active …

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Structural Assembly Of The Pas Domain Drives The Catalytic Activation Of Metazoan Pask, Sajina Dhungel, Michael Xiao, Rajesh Rajaian Pushpabai, Chintan K. Kikani Mar 2025

Structural Assembly Of The Pas Domain Drives The Catalytic Activation Of Metazoan Pask, Sajina Dhungel, Michael Xiao, Rajesh Rajaian Pushpabai, Chintan K. Kikani

Biology Faculty Publications

PAS domains are ubiquitous sensory modules that transduce environmental signals into cellular responses through tandem PAS folds and PAS-associated C-terminal (PAC) motifs. While this conserved architecture underpins their regulatory roles, here we uncover a structural divergence in the metazoan PAS domain-regulated kinase (PASK). By integrating evolutionary-scale domain mapping with deep learning-based structural models, we identified two PAS domains in PASK, namely PAS-B and PAS-C, in addition to the previously known PAS-A domain. Unlike canonical PAS domains, the PAS fold and PAC motif in the PAS-C domain are spatially segregated by an unstructured linker, yet a functional PAS module is assembled …

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Assessing Coronavirus Disease 2019 Pandemic Impacts On The Health Of People Who Inject Drugs Using A Novel Data Sharing Model, Heather Bradley, Nicole Luisi, Anastasia Carter, Terri D. Pigott, Daniela Abramovitz, Sean T. Allen, Alice Asher, Chelsea Austin, Tyler S. Bartholomew, Marianna Baum, Amy Board, Basmattee Boodram, Annick Borquez, Kathryn A. Brookmeyer, Kate Buchacz, Janet Burnett, Hannah L.F. Cooper, Nicole Crepaz, Kora Debeck, Judith Feinberg, Chunki Fong, Edward Freeman, Nathan Woo Furukawa, Becky Genberg, Pamina Gorbach, Holly Hagan, Kanna Hayashi, Emalie Huriaux Mar 2025

Assessing Coronavirus Disease 2019 Pandemic Impacts On The Health Of People Who Inject Drugs Using A Novel Data Sharing Model, Heather Bradley, Nicole Luisi, Anastasia Carter, Terri D. Pigott, Daniela Abramovitz, Sean T. Allen, Alice Asher, Chelsea Austin, Tyler S. Bartholomew, Marianna Baum, Amy Board, Basmattee Boodram, Annick Borquez, Kathryn A. Brookmeyer, Kate Buchacz, Janet Burnett, Hannah L.F. Cooper, Nicole Crepaz, Kora Debeck, Judith Feinberg, Chunki Fong, Edward Freeman, Nathan Woo Furukawa, Becky Genberg, Pamina Gorbach, Holly Hagan, Kanna Hayashi, Emalie Huriaux

Epidemiology and Environmental Health Faculty Publications

Objective: Using an innovative data sharing model, we assessed the impacts of the COVID-19 pandemic on the health of people who inject drugs (PWID). Design: The PWID Data Collaborative was established in 2021 to promote data sharing across PWID studies in North America. Contributing studies submitted aggregate data on 23 standardized indicators during four time periods: prepandemic (March 2019 to February 2020), early-pandemic (March 2020 to February 2021), mid-pandemic (March 2021 to February 2022), and late pandemic (March 2022 to February 2023). Methods: We present study-specific and meta-analyzed estimates for the percentage of PWID who took medications for opioid use …

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A Satellite Cell-Dependent Epigenetic Fingerprint In Skeletal Muscle Identity Genes After Lifelong Physical Activity, Kevin A. Murach, Davis A. Englund, Toby L. Chambers, Cory M. Dungan, Hunter L. Porter, Jonathan D. Wren, Willard M. Freeman, Esther E. Dupont-Versteegden, Yuan Wen Mar 2025

A Satellite Cell-Dependent Epigenetic Fingerprint In Skeletal Muscle Identity Genes After Lifelong Physical Activity, Kevin A. Murach, Davis A. Englund, Toby L. Chambers, Cory M. Dungan, Hunter L. Porter, Jonathan D. Wren, Willard M. Freeman, Esther E. Dupont-Versteegden, Yuan Wen

Physiology Faculty Publications

Satellite cells comprise a small proportion of mononuclear cells in adult skeletal muscle. Despite their relative rarity, satellite cells have critical functions in muscle adaptation, particularly during prolonged exercise training. The mechanisms by which satellite cells mediate skeletal muscle responsiveness to physical activity throughout the lifespan are still being defined, but epigenetic regulation may play a role. To explore this possibility, we analyzed global DNA methylation patterns in muscle tissue from female mice that engaged in lifelong voluntary unweighted wheel running with or without satellite cells. Satellite cells were ablated in adulthood using the tamoxifen-inducible Pax7-DTA model. Compared to sedentary …

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Closing Ceremony Speech, S. Ray Smith Mar 2025

Closing Ceremony Speech, S. Ray Smith

IGC Proceedings (1977-2023)

No abstract provided.

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Soil Compaction And Novel Traffic Systems In Ryegrass Grown For Silage: Effects On Herbage Yield, Quality And Nitrogen Uptake, J T. Douglas, C E. Crawford Mar 2025

Soil Compaction And Novel Traffic Systems In Ryegrass Grown For Silage: Effects On Herbage Yield, Quality And Nitrogen Uptake, J T. Douglas, C E. Crawford

IGC Proceedings (1977-2023)

Grassland soils, on which the crop is managed for conser­vation as silage, receive large amounts of vehicle and machinery traffic : rolling and multiple slurry and fertilizers applications, plus multiple harvests, are all activities which are potentially damaging to soil and sward. A number of short-term studies in the UK (Frame, 1987 and Frost, 1988) and elsewhere (Luten and Roozeboom, 1976, and Rasmussen and M¢ller, 1981) have indicated that dry matter yield can be reduced as a consequence of stress imparted to soil by agricultural tyres. Nevertheless, there is a general lack of information on the influence of soil compaction …

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