Digital Commons Network^™

Smoking-Induced Sex Differences In Clinical Outcomes In Patients Undergoing Mechanical Thrombectomy For Stroke, Jacqueline A. Frank, Kara Jo Swafford, Jill M. Roberts, Amanda L. Trout, Ann M. Stowe, Douglas E. Lukins, Stephen Grupke, Keith R. Pennypacker, Justin F. Fraser

Neurology Faculty Publications

OBJECTIVE: Ischemic stroke is the fifth leading cause of death in the United States. Smoking accelerates the onset of stroke by 10 years. The effects of smoking status on percent change in National Institutes of Health Stroke Scale (NIHSS) score, infarct volume, and edema volume were examined following mechanical thrombectomy for large vessel occlusion in patients with acute ischemic stroke.

METHODS: Subjects (N = 90; >18 years old) were divided into 3 groups based on smoking status: current smokers, previous smokers (defined as having quit >6 months before the ischemic event), and nonsmokers. Percent change in NIHSS score was …

Oncogenic Osteomalacia Secondary To Glomus Tumor, Rishi Raj, Samaneh Hasanzadeh, Mitra Dashtizadeh, Mohammadreza Kalantarhormozi, Katayoun Vahdat, Mohammad Hossein Dabbaghmanesh, Iraj Nabipour, Mohammdreza Ravanbod, Majid Assadi, Basir Hashemi, Kamyar Asadipooya

Internal Medicine Faculty Publications

Summary

Oncogenic osteomalacia secondary to glomus tumor is extremely rare. Localization of causative tumors is critical as surgical resection can lead to a complete biochemical and clinical cure. We present a case of oncogenic osteomalacia treated with resection of glomus tumor. A 39-year-old woman with a history of chronic sinusitis presented with chronic body ache and muscle weakness. Biochemical evaluation revealed elevated alkaline phosphatase hypophosphatemia, increased urinary phosphate excretion, low calcitriol, and FGF23 was unsuppressed suggestive of oncogenic osteomalacia. Diagnostic studies showed increase uptake in multiple bones. Localization with MRI of paranasal sinuses revealed a sinonasal mass with concurrent uptake …

Effect Of Metformin On The High-Density Lipoprotein Proteome In Youth With Type 1 Diabetes, Evgenia Gourgari, Kristen J. Nadeau, Laura Pyle, Martin P. Playford, Junfeng Ma, Nehal N. Mehta, Alan T. Remaley, Scott M. Gordon

Saha Cardiovascular Research Center Faculty Publications

Background: Youth with type 1 diabetes (T1D) have normal or elevated High-Density Lipoprotein Cholesterol (HDL-C), however, the function of HDL, partly mediated by the HDL proteome, may be impaired. Metformin can be used as an adjunct therapy in youth with T1D, but its effects on the HDL proteome are unknown.

Objective: To determine the effect of metformin on the HDL proteome.

Subjects: Youth (12-20 years old) with T1D who had a BMI > 90th percentile, HbA1c > 8.0% and Tanner stage 5.

Methods: Double-blinded, placebo-controlled randomized sub-study. We examined the effects of metformin (n = 25) or placebo (n = …

Risk-Based Construction Inspection, Timothy Taylor, Shannon Rush, Steve Waddle, Hala Nassereddine, Ryan Griffith, Makram Bou Hatoum

Kentucky Transportation Center Research Report

Retirements and other forms of attrition have reduced employment levels at the Kentucky Transportation Cabinet (KYTC) over the past 20 years. Left in the wake of staff departures is a younger and more inexperienced workforce that shoulders numerous responsibilities. Although operations throughout the Cabinet have been affected by staff losses, construction inspection has suffered disproportionately. Strategies for mitigating the impacts of staff loss include robust knowledge management and risk-based construction inspection. This project developed several tools to help KYTC implement a risk-based construction inspection program, including (1) heat maps that qualitatively rate the levels of risk for different construction activities; …

Evaluation Of Liquid Deicing Materials For Winter Maintenance Applications, Erin Lammers-Staats

Kentucky Transportation Center Research Report

Winter weather can often pose difficulties for transportation agencies as they work to clear roads of snow and ice quickly so that motorists can travel safely and efficiently. Kentucky has made efforts to maximize efficiency within its winter maintenance program by focusing on optimized equipment usage and personnel time management. In this study, KYTC evaluated anti-icers and how their performance compared to the current performance of brine and calcium chloride mixture. New brine additives claim to offer better results, but there is very little guidance about how to systematically evaluate new anti-icers. Researchers were tasked with developing a testing methodology …

Effect Of Silicon On Early Growth And Yields Of Alfalfa (Medicago Sativa), Fuping Tian

IGC Proceedings (1977-2023)

No abstract provided.

Pattern Of Above‐Ground Biomass Accumulation In Maize Cultivars Grown For Silage, Jose L. Zaragoza‐Ramirez, E. Cortes‐Diaz, Pedro A. Martinez‐Hernandez, R. Manzano‐Luna, M. Mendoza‐Rodriguez, D. H. Faggi

IGC Proceedings (1977-2023)

No abstract provided.

Study On Drying Characteristic And Hay Quality Of Alfalfa In Different Hay Making Methods, Shiming Xue, Guilian Shan

IGC Proceedings (1977-2023)

No abstract provided.

Correlation And Path Cofficient Analysis Of Dry Fodder Yield And Its Attributes In Dual Purpose Pearl Millet (Pennisetum Glaucum), Yash Pal Yadav, Shashi Kant, H. P. Yadav

IGC Proceedings (1977-2023)

No abstract provided.

Chemical Composition And Seasonal Yield Of Koeleria Cristata In West Azarbaijan Grasslands Of Iran, Javad Torkan, I. Bernosi

IGC Proceedings (1977-2023)

No abstract provided.

Hierarchical Harmonization Of Atom-Resolved Metabolic Reactions Across Metabolic Databases, Huan Jin, Hunter N. B. Moseley

Molecular and Cellular Biochemistry Faculty Publications

Metabolic models have been proven to be useful tools in system biology and have been successfully applied to various research fields in a wide range of organisms. A relatively complete metabolic network is a prerequisite for deriving reliable metabolic models. The first step in constructing metabolic network is to harmonize compounds and reactions across different metabolic databases. However, effectively integrating data from various sources still remains a big challenge. Incomplete and inconsistent atomistic details in compound representations across databases is a very important limiting factor. Here, we optimized a subgraph isomorphism detection algorithm to validate generic compound pairs. Moreover, we …

Factors That Influence Enrollment In Syringe Services Programs In Rural Areas: A Qualitative Study Among Program Clients In Appalachian Kentucky, Umedjon Ibragimov, Katherine E. Cooper, Evan Batty, April M. Ballard, Monica Fadanelli, Skylar B. Gross, Emma M. Klein, Scott Lockard, April M. Young, Hannah L. F. Cooper

Epidemiology and Environmental Health Faculty Publications

BACKGROUND: Enrolling sufficient number of people who inject drugs (PWID) into syringe services programs (SSP) is important to curtail outbreaks of drug-related harms. Still, little is known about barriers and facilitators to SSP enrollment in rural areas with no history of such programs. This study's purpose was to develop a grounded theory of the role of the risk environment and individual characteristics of PWID in shaping SSP enrollment in rural Kentucky.

METHODS: We conducted one-on-one semi-structured interviews with 41 clients of 5 SSPs that were established in rural counties in Appalachian Kentucky in 2017-2018. Interviews covered PWID needs, the process …

Analysis Of Genetic Variants Associated With Levels Of Immune Modulating Proteins For Impact On Alzheimer’S Disease Risk Reveal A Potential Role For Siglec14, Benjamin C. Shaw, Yuriko Katsumata, James F. Simpson, David W. Fardo, Steven Estus

Biostatistics Faculty Publications

Genome-wide association studies (GWAS) have identified immune-related genes as risk factors for Alzheimer’s disease (AD), including TREM2 and CD33, frequently passing a stringent false-discovery rate. These genes either encode or signal through immunomodulatory tyrosine-phosphorylated inhibitory motifs (ITIMs) or activation motifs (ITAMs) and govern processes critical to AD pathology, such as inflammation and amyloid phagocytosis. To investigate whether additional ITIM and ITAM-containing family members may contribute to AD risk and be overlooked due to the stringent multiple testing in GWAS, we combined protein quantitative trait loci (pQTL) data from a recent plasma proteomics study with AD associations in a recent …

The Perception Of Management Needs In Bolivian Rural Communities, Andrea Pardini, L. Angeli, F. Peduzzi

IGC Proceedings (1977-2023)

No abstract provided.

Deriving Basic Principles In Sustainable Management From Local Knowledge: Modelling Himba's Grazing Regime (Namibia), Birgit Müller, Anja Linstädter, K. Frank, M. Bollig, C. Wissel

IGC Proceedings (1977-2023)

No abstract provided.

Nomadic Culture, A Mirror For Current Grassland Policy—A Case Of Grassland Of Inner Mongolia Of China, Nianyong Han

IGC Proceedings (1977-2023)

No abstract provided.

Concurrent Covid-19 Infection In Children With Acute Appendicitis: A Report Of Three Cases, Maximo J. Acevedo, Dylan Steffey, Johanne E. Dillon, James T. Lee, David J. Worhunsky

Radiology Faculty Publications

Literature describing patients with concomitant COVID-19 infection with acute appendicitis in pediatric patients is growing, and understanding the clinical picture of such patients is relevant in their treatment. We report 3 male children who were surgically treated for acute appendicitis and had concomitant SARS-CoV-2 infection. Our first patient was a 12-year-old male who presented with symptoms indicative of appendicitis but no respiratory symptoms associated with COVID-19 (eg cough, shortness of breath). Laboratory evaluation revealed leukopenia and an elevated C-reactive protein; imaging was consistent with acute appendicitis and an acute pulmonary viral infection. Though he lacked diffuse peritonitis on physical examination …

Commercial Grazing Versus Peri‐Urbanisation: Comparisons Of Landscape Condition, Cam K. Mcdonald, Neil D. Macleod, John G. Mcivor, F. Kearney

IGC Proceedings (1977-2023)

No abstract provided.

Mongolian O‐Boo Culture And Biodiversity Conservation In Arbas Mountain, Ordos Plateau, Manliang, Surguga, Shan Chen, Xinshi Zhang

IGC Proceedings (1977-2023)

No abstract provided.

Social And Cultural Implications Of Scaling Out Livestock Production In The Lao Pdr, Joanne Millar

IGC Proceedings (1977-2023)

No abstract provided.

From Nomadism To Agro‐Pastoralism: Strategies To Survive Ecological Challenges By The Maasai Community In Kenya, P. N. Macharia

IGC Proceedings (1977-2023)

No abstract provided.

Changed Relations: Understanding Conflicts In Pastoral Areas, Shaoliang Yi, Ning Wu, Zhaoli Yan, Ismail Muhammad

IGC Proceedings (1977-2023)

No abstract provided.

Necessity Of Mobility Strategy To Risk Aversion Livestock Husbandry: A Case From Bayantala Village Of Xilingol Prefecture, Inner Mongolia, China, Yina Xie, Wenjun Li, Qian Zhang, Changling Li, Yanbo Li

IGC Proceedings (1977-2023)

No abstract provided.

Traditional Knowledge Of Mongolian Pastoralists And Scientific Evidence—A Case Study At A Forest‐Steppe In Northern Mongolia, Yuki Morinaga, T. Ozaki, K. Kakinuma, S. Takatsuki, J. Chuluun

IGC Proceedings (1977-2023)

No abstract provided.

Investigation Of The Internal Mechanism Of Pastoral Population And Grassland Degeneration—Using Xilingol As An Example, Ying Tian

IGC Proceedings (1977-2023)

No abstract provided.

Cattle Producer Perceptions Of Their Grazing Systems In The Rangelands Of Northern Australia, Cristine Hall, Trevor Hall

IGC Proceedings (1977-2023)

No abstract provided.

Covid-19 And The Impact On Rural And Black Church Congregants: Results Of The C-M-C Project, Lovoria B. Williams, Anita F. Fernander, Tofial Azam, Maria L. Gomez, Junghee Kang, Cassidy L. Moody, Hannah Bowman, Nancy E. Schoenberg

Clinical and Translational Science Faculty Publications

The COVID‐19 pandemic has had devastating effects on Black and rural populations with a mortality rate among Blacks three times that of Whites and both rural and Black populations experiencing limited access to COVID‐19 resources. The primary purpose of this study was to explore the health, financial, and psychological impact of COVID‐19 among rural White Appalachian and Black nonrural central Kentucky church congregants. Secondarily we sought to examine the association between sociodemographics and behaviors, attitudes, and beliefs regarding COVID‐19 and intent to vaccinate. We used a cross sectional survey design developed with the constructs of the Health Belief and Theory …

Reduced Mitochondrial Dna And Oxphos Protein Content In Skeletal Muscle Of Children With Cerebral Palsy, Ferdinand Von Walden, Ivan J. Vechetti Jr., Davis A. Englund, Vandré C. Figueiredo, Rodrigo Fernandez-Gonzalo, Kevin A. Murach, Jessica Pingel, John J. Mccarthy, Per Stål, Eva Pontén

Physiology Faculty Publications

AIM: To provide a detailed gene and protein expression analysis related to mitochondrial biogenesis and assess mitochondrial content in skeletal muscle of children with cerebral palsy (CP).

METHOD: Biceps brachii muscle samples were collected from 19 children with CP (mean [SD] age 15y 4mo [2y 6mo], range 9-18y, 16 males, three females) and 10 typically developing comparison children (mean [SD] age 15y [4y], range 7-21y, eight males, two females). Gene expression (quantitative reverse transcription polymerase chain reaction [PCR]), mitochondrial DNA (mtDNA) to genomic DNA ratio (quantitative PCR), and protein abundance (western blotting) were analyzed. Microarray data sets (CP/aging/bed rest) were …

A Research Of The Living Environment In The Pasturing Area, Yajuan Guo, Yong Gao, Xu Sun

IGC Proceedings (1977-2023)

No abstract provided.

Indigenous Knowledge‐Sustainable Decisions Comparing Local And Scientific Use Of Plants As Indicators, Gisela Baumann, B. Kemmerling, Anja Linstädter

IGC Proceedings (1977-2023)

No abstract provided.