Digital Commons Network^™

Comparative Growth Performance Of West African Dwarf Goat Supplemented With Calliandra Calothyrsus, Leucaena Leucocephala, Or Cotton Seed Cake In West Cameroon, E. Tedonkeng Pamo, G. D. Assontia, C. Njehoya

IGC Proceedings (1977-2023)

A comparative growth performance study of African Dwarf Goats supplemented with Calliandra calothyrsus, Leucaena leucocephala or cotton seed cake was carried out on farm around Dschang and in the University Experimental Farm. Goats between 12 and 16 months of age were divided into 4 groups of 11 goats each with one group kept as a control. The supplemented animals received respectively 390 g of L. leucocephala, 380 g of C. calothyrsus (fresh matter) and 88.8 g of cotton seed cake each, corresponding to 6 g of nitrogen per animal per day. The animals were weighed every 21 days …

Voluntary Intake Of Tanzania Grass (Panicum Maximum) Under Rotational Grazing By Lactating Cows, M. L. P. Lima, T. T. Berchielli, J. R. Nogueira, A. K. D. Salman, Ana C. Ruggieri, Paulo Roberto Leme, L. J. M. Aroeira, J. P. G. Soares

IGC Proceedings (1977-2023)

The study was conducted at Nucleo de Pesquisas Zootecnicas Nordeste of the Instituto de Zootecnia, Ribeirão Preto, SP, in a rotational grazing area of Tanzania grass (Panicum maximum), to estimate the dry matter intake by lactanting cows. The estimation of dry matter intake was calculated from the feces production estimated using extrusa Chromium-mordent and the in vitro digestibility of diet. The three treatments were crossbreed cows fed 3 kg.day^-1 of concentrate, crossbred cows without concentrate suplementation and pure Gir cows also without concentrate supplementation. The milk production was 11.98, 6.53 and 5.46 kg per cow per day, …

The Effect Of Browse Species When Fed As A Supplement To Low Quality Native Grass Hay On Animal Performance, A. Elgersma, J. F. Oerlemans, D. B. Coates

IGC Proceedings (1977-2023)

A pen trial was conducted to measure the impact of some browse species when fed as a supplement on the nitrogen (N) and dry matter intake of cattle receiving low quality native grass hay. There were 8 treatments consisting of a nil-supplement control treatment, a urea supplement control, a green oaten hay control and 5 treatment groups based on browse supplements (Albizia lebbeck, Carissa spp. and Bursaria spp.). Treatment effect on increased native pasture intake was related to the amount of supplementary nitrogen (N), such that there was a significant linear relationship between dry matter intake of native …

Effects Of Different Levels Of Energy Supplementation On Growth Of Grazing Holstein Heifers, L. P. Novaes, C. E. Polan

IGC Proceedings (1977-2023)

Growth of Holstein heifers was studied for 1987 grazing season to evaluate pasture-drylot systems for raising dairy replacements. Orchardgrass (Dactylis glomerata L), tall fescue (Festuca arundinacea Schreb), bluegrass (Poa pratensis L) and white (Trifolium repens L) and red clover (Trifolium pratense, L) were the principal components of the grass-legume mixture in six paddocks of 1.5 ha each. Carrying capacity was estimated at six animals/ha (3.1 animal units) and excess forage was harvested as hay to control forage growth and quality. Grazing days were 140 days. None or 2.0 kg/d …

Intake And Growth Of Steers Offered Different Allowances Of Autumn Grass And Concentrates, Edward G. O’Riordan, P. French, Padraig O’Kiely, A. P. Moloney

IGC Proceedings (1977-2023)

The aim of this experiment was to quantify the relationship between autumn grass supply and concentrate supplementation level on grass intake and animal performance. One hundred and ten continental steers (567kg) were assigned to ten treatments in a three grass allowances: (6, 12 and 18kg dry matter (DM) per head daily) by three concentrate levels: (0, 2.5 and 5kg/head/daily) factorial design with a positive control group offered concentrates ad-libitum. Grass allowance was offered daily and concentrates were fed individually. The experiment began on August 22 and all animals were slaughtered after a mean experimental period of 95 days. Grass …

Fatty Acid Composition And Eating Quality Of Muscle From Steers Offered Grazed Grass, Grass Silage Or Concentrate-Based Diets, A. P. Moloney, P. French

IGC Proceedings (1977-2023)

The effects of grazed grass, grass silage or concentrates on the eating quality and fatty acid composition of intra-muscular fat of steers fed to achieve similar carcass growth rates were investigated. Fifty steers were assigned to one of five dietary treatments. The experimental rations offered daily for 85 days pre-slaughter were (a) grass silage plus 4 kg concentrate, (b) 8 kg concentrate plus 1 kg hay, (c) 6 kg grazed grass dry matter (DM) plus 5 kg concentrate, (d) 12 kg grazed grass DM plus 2.5 kg concentrate or (e) 22 kg grazed grass DM. Decreasing the proportion of concentrate …

Supplementation Of Lactating Cows Grazing Stargrass (Cynodon Nlenfuensis Var. Nlenfuensis) With Conjugated Linoleic Acid: Effects On Persistency And Estimated Net Energy Balance, S. R. Medeiros, D. E. Oliveira, L. J. M. Aroeira, M. Mcguire, D. P. D. Lanna

IGC Proceedings (1977-2023)

Thirty crossbread cows grazed stargrass (Cynodon nlenfuensis var. nlenfuensis) receiving 4kg/d of a supplement formulated to provide 115% of metabolizable protein requirements from the 4^th to the 11^th week of lactation. The cows received either 150g/head/day of Megalac (Control) or 150g/head/day of a Ca-protected conjugated linoleic acid (CLA, Church & Dwight). Residual effects of treatment were evaluated in weeks 12^th and 13^th. Milk production increased in CLA treated cows (P< 0.05). CLA decreased milk fat content (P< 0.0001) and yield (P< 0.01). Protected CLA increased protein content (P< 0.01) and yield (P< 0.01). The CLA residual effect on milk fat ends within one week after withdrawal but the benefits on milk yield and total solids production continued, due to the increased persistency. The estimated energy balance and intake were not greatly affected by treatment, as treated cows had higher milk volume and had higher protein productions.

Physician-Perceived Barriers To Treating Opioid Use Disorder In The Emergency Department, Gideon Logan, Amber Mirajkar, Jessica Houck, Fernando Rivera-Alvarez, Emily Drone, Parth Patel, Alexandra Craen, Larissa Dub, Nubaha Elahi, David Lebowitz, Ayanna Walker, Latha Ganti

Emergency Medicine Faculty Publications

Objective

We aimed to assess physicians' perceptions of barriers to starting medication-assisted treatment (MAT) in the Emergency Department (ED), views of the utility of MAT, and abilities to link patients with opioid use disorder (OUD) to MAT programs in their respective communities.

Methods

This was a cross-sectional survey study of American emergency medicine (EM) physicians with a self-administered online survey via SurveyMonkey (Survey Monkey, San Mateo, California). The survey was emailed to the Council of Residency Directors in Emergency Medicine (CORD) listserv and HCA Healthcare affiliated EM residency programs' listservs. Attendings and residents of all post-graduate years participated. Questions assessed …

Rapid And Direct Action Of Lipopolysaccharide (Lps) On Skeletal Muscle Of Larval Drosophila, Rachel Potter, Alexis Meade, Samuel Potter, Robin L. Cooper

Biology Faculty Publications

The endotoxin lipopolysaccharide (LPS) from Gram-negative bacteria exerts a direct and rapid effect on tissues. While most attention is given to the downstream actions of the immune system in response to LPS, this study focuses on the direct actions of LPS on skeletal muscle in Drosophila melanogaster. It was noted in earlier studies that the membrane potential rapidly hyperpolarizes in a dose-dependent manner with exposure to LPS from Pseudomonas aeruginosa and Serratia marcescens. The response is transitory while exposed to LPS, and the effect does not appear to be due to calcium-activated potassium channels, activated nitric oxide synthase …

Exploring The Digital Humanities Research Agenda: A Text Mining Approach, Soohyung Joo, Jennifer Hootman, Marie Katsurai

Information Science Faculty Publications

Purpose

This study aims to explore knowledge structure and research trends in the domain of digital humanities (DH) in the recent decade. The study identified prevailing topics and then, analyzed trends of such topics over time in the DH field.

Design/methodology/approach

Research bibliographic data in the area of DH were collected from scholarly databases. Multiple text mining techniques were used to identify prevailing research topics and trends, such as keyword co-occurrences, bigram analysis, structural topic models and bi-term topic models.

Findings

Term-level analysis revealed that cultural heritage, geographic information, semantic web, linked data and digital media were among the most …

Use Of Supplements For Maintenance Of Nelore Bullocks In Brachiaria Decumbens, During The Dry Season In Acre, Brazilian Amazon, J. C. Carneiro, Judson F. Valentim, L. A. R. Valle

IGC Proceedings (1977-2023)

This study had the objective of evaluating animal performance and net economic returns of Nelore bullocks receiving: 1) mineral mixture (MM), 2) mineral mixture + urea (MMU), and 3) multiple supplement (MS), during the dry season of 1999 in Acre, Brazilian Amazon. The animals were maintained in pastures of Brachiaria decumbens, and liveweight gains, forage availability and chemical composition were assessed during the experimental period. Liveweight gains of 0.58, 0.65 and 0.60 kg/day, respectively, for MM, MMU and MS, were not different (P> 0.05). The use of MMU provided additional net economic return of 10.8% in comparison with the …

Roots And Potatoes As Supplements To An Alfalfa – Grass Diet To Dairy Cows, T. Eriksson, P. Ciszuk, E. Burstedt

IGC Proceedings (1977-2023)

Fourteen multiparous dairy cows were used in 3 x 3 change-over experiment designed to study effects of replacing barley by roots and potatoes in diets based on leguminous forage on feed intake, milk production and utilisation of feed nitrogen. The cows received a mixture of alfalfa (Medicago L.) and grass silage ad libitum and an isoenergetic quantity of a supplement based on either barley and potatoes (Ba/P), fodder beets (Beta vulgaris L.) and potatoes (Be/P) or barley (Ba). The grass in grass silage was dominated by timothy (Phleum pratense L.). Total DM intake as well as yield …

Agronomic Evaluation Of Forage Grasses Under Mature Rubber Plantation, N. L. Costa, Valdinei T. Paulino, A. C. M. Igreja, C. R. Townsend, J. A. Magalhães, R. G. De A Pereira, T. S. Paulino

IGC Proceedings (1977-2023)

The agronomic performance of seven forage grasses, under a mature rubber plantation, was assessed in a cutting trial carried out at Porto Velho, Rondônia. During the rainy season, the higher dry matter yields were obtained with B. brizantha, P. atratum BRA-9610 and B. humidicola. During the dry season, the grasses more productive were B. brizantha and P. atratum BRA-9610. In both seasons, magnesium and potassium contents did not vary among grasses. During the rainy season, the higher nitrogen and phosphorus contents were obtained with P. regnelli BRA-0159 and, P. guenoarum BRA-3824 and B. humidicola, respectively, while P. atratum …

Constraints And Opportunities For Development Of Grasslands In Urban Areas Of The Niayes Zone In Senegal, S. T. Fall, I. Cissé

IGC Proceedings (1977-2023)

A survey was carried out in urban areas of the Niayes zone in Senegal to explore grasslands development in agropastoral systems around towns. Rapid rural appraisal and farms multiple visits were done to describe the forage cropping system, identify constraints and opportunities of developing grasslands in urban areas. In Niayes urban areas, forage production system is being developed based on the cropping of several grass and tree species. Only a minority of farmers is involved in that activity. Level of grass production is rather low. Weak development of grasslands is observed. Main reasons are: farmer poor willingness to crop for …

Semiarid Grassland And Winter Cereals For Lamb Production In Northeast Patagonia, Argentina, D. P. Miñón, G. G. Durañona, J. C. García Vinent, H. D. Giorgetti, G. D. Rodríguez

IGC Proceedings (1977-2023)

In northeastern Patagonia where grain crops often led to harvest failure, low yields and a high drought risk, a lamb production system was established. On a 10 years old agriculture wheat cropping was interrupted in 1996, allowing re-vegetation through exclusion of grazing. Natural grassland recovered, prevailing the species Stipa tenuis, Piptochaetium napostaense, Stipa ambigua. Part of the plot was sown to wheat grass (Thinopyrum ponticum). In 1999, to improve sheep feeding, oat (Avena sativa) and barley (Hordeum vulgare) were sown for grazing during winter-spring season. In this system Corriedale sheep, Texel x australian …

Bilateral Popliteal Entrapment Syndrome In A Young Athlete Diagnosed With Ultrasound, Hanna K. Thompson, Justin R. Montgomery, Paul J. Spicer

Radiology Faculty Publications

Popliteal artery entrapment syndrome (PAES) occurs when the popliteal artery is compressed by abnormally developed or hypertrophied muscles adjacent to the popliteal fossa. When symptomatic, it most frequently presents with leg cramping while walking or running. We describe the case of an 18-year-old female runner presenting with claudication and exercise intolerance. After MRI was non-diagnostic, diagnostic ultrasound demonstrated that she had functional (Type VI) PAES. She subsequently underwent popliteal artery release surgery. Type VI PAES should be considered in young, healthy patients who present with claudication, particularly athletes.

Characterizing Long Covid: Deep Phenotype Of A Complex Condition, Rachel R. Deer, Madeline A. Rock, Nicole Vasilevsky, Leigh Carmody, Halie Rando, Alfred J. Anzalone, Marc D. Basson, Tellen D. Bennett, Timothy Bergquist, Eilis A. Boudreau, Carolyn T. Bramante, James Brian Byrd, Tiffany J. Callahan, Lauren E. Chan, Haitao Chu, Christopher G. Chute, Ben D. Coleman, Hannah E. Davis, Joel Gagnier, Casey S. Greene, Ramakanth Kavuluru

Institute for Biomedical Informatics Faculty Publications

BACKGROUND: Numerous publications describe the clinical manifestations of post-acute sequelae of SARS-CoV-2 (PASC or "long COVID"), but they are difficult to integrate because of heterogeneous methods and the lack of a standard for denoting the many phenotypic manifestations. Patient-led studies are of particular importance for understanding the natural history of COVID-19, but integration is hampered because they often use different terms to describe the same symptom or condition. This significant disparity in patient versus clinical characterization motivated the proposed ontological approach to specifying manifestations, which will improve capture and integration of future long COVID studies.

METHODS: The Human Phenotype Ontology …

Landomycins As Glutathione-Depleting Agents And Natural Fluorescent Probes For Cellular Michael Adduct-Dependent Quinone Metabolism, Alessio Terenzi, Mery La Franca, Sushilla Van Schoonhoven, Rostyslav Panchuk, Álvaro Martínez, Petra Heffeter, Redding Gober, Christine Pirker, Petra Vician, Christian R. Kowol, Rostyslav Stoika, Luca Salassa, Jürgen Rohr, Walter Berger

Pharmaceutical Sciences Faculty Publications

Landomycins are angucyclines with promising antineoplastic activity produced by Streptomyces bacteria. The aglycone landomycinone is the distinctive core, while the oligosaccharide chain differs within derivatives. Herein, we report that landomycins spontaneously form Michael adducts with biothiols, including reduced cysteine and glutathione, both cell-free or intracellularly involving the benz[a]anthraquinone moiety of landomycinone. While landomycins generally do not display emissive properties, the respective Michael adducts exerted intense blue fluorescence in a glycosidic chain-dependent manner. This allowed label-free tracking of the short-lived nature of the mono-SH-adduct followed by oxygen-dependent evolution with addition of another SH-group. Accordingly, hypoxia distinctly stabilized the fluorescent mono-adduct. While …

Nutritive Quality Of Tropical Grasses Sown Under A Pine Plantation, D. Gutmanis, Antonio João Lourenço, V. B. G. Alcantara, Maria T. Colozza

IGC Proceedings (1977-2023)

A trial was conducted in Brazil to evaluate the nutritive quality of 6 tropical grasses: tanzania (Panicum maximum cv. Tanzania), green-panic (P. maximum var. Trichoglume), aruana (P. maximum cv. Aruana), brizanta (Brachiaria brizantha), humidicola (B. humidicola) and tifton-85 (Cynodon dactylon cv. Tifton 85), planted under two different densities of pines (Pinus elliottis): 200 and 400 stems/ha, as well as in full sunlight. The results showed a significant increase in protein content and a significant decrease in NDF and cellulose contents as tree density increased. Comparing the values obtained under shading conditions …

Production And Mineral Composition Of Tropical Grasses Sown Under A Pine Plantation, D. Gutmanis, V. B. G. Alcantara, Maria T. Colozza, Antonio João Lourenço

IGC Proceedings (1977-2023)

A trial was conducted in Brazil to evaluate the performance of 6 tropical grasses: tanzania (Panicum maximum cv. Tanzania), green-panic (P. maximum var. Trichoglume), aruana (P. maximum cv. Aruana), brizanta (Brachiaria brizantha), humidicola (B. humidicola) and tifton-85 (Cynodon dactylon cv. Tifton 85), planted under two different densities of pines (Pinus elliottis): 200 and 400 stems/ha, as well as in the full sunlight. The results showed that the dry matter yield decreased as shading increased. The grasses tanzania and brizanta were the most tolerant to shading. Although N concentration increased with …

Dry Matter Production And Nutritive Value Of Alfalfa (Medicago Sativa L.) And Orchardgrass (Dactylis Glomerata L.) Under Different Light Regimes, A. C. Varella, P. L. Peri, R. J. Lucas, D. J. Moot, D. L. Mcneil

IGC Proceedings (1977-2023)

Spring and summer alfalfa dry matter and nitrogen production rates were greater than orchardgrass in open pasture and under three shade levels. Ten years old Pinus radiata allowed 60% light transmissivity. The addition of artificial shade resulted in 45% and 25% transmissivity. Orchardgrass pastures were nitrogen deficient and water stressed. In contrast, alfalfa was not stressed and it was more light responsive than orchardgrass. Differences in nutritive value were relatively small between species and between light regimes. Sheep liveweight gain on alfalfa was greater than on orchardgrass. Orchardgrass demonstrated shade tolerance, but alfalfa was more productive even at 25% transmissivity. …

Different Methods Of Artificial Shade For Agro-Silvipastoral Research, A. C. Varella, D. J. Moot, R. J. Lucas, D. L. Mcneil, P. L. Peri, K. M. Pollock

IGC Proceedings (1977-2023)

Artificial shading sources are used to simulate silvipastoral light environments and study the effect of shade on pasture. Different sources of shade may not imitate normal forest light environment. An experiment was conducted to examine the light environment and effect on pasture yield components of two artificial shading materials. Alfalfa (Medicago sativa L.) pasture was submitted to three light regimes: full sunlight (100% transmissivity); black shade cloth (40%) and wooden slats (45%).

The pattern of light exposure for plants differed under slats and shade cloth, but light intensity and quality were similar. Alfalfa dry matter (DM) yield and leaf …

Analysis Of Hendra Virus Fusion Protein N-Terminal Transmembrane Residues, Chelsea T. Barrett, Hadley E. Neal, Kearstin Edmonds, J. Lizbeth Reyes Zamora, Carole L. Moncman, Andreea Popa, Everett Clinton Smith, Stacy R. Webb, Rebecca Ellis Dutch

Molecular and Cellular Biochemistry Faculty Publications

Hendra virus (HeV) is a zoonotic enveloped member of the family Paramyoxviridae. To successfully infect a host cell, HeV utilizes two surface glycoproteins: the attachment (G) protein to bind, and the trimeric fusion (F) protein to merge the viral envelope with the membrane of the host cell. The transmembrane (TM) region of HeV F has been shown to have roles in F protein stability and the overall trimeric association of F. Previously, alanine scanning mutagenesis has been performed on the C-terminal end of the protein, revealing the importance of β-branched residues in this region. Additionally, residues S490 and Y498 have …

Modeling Of Groundwater Potential Using Cloud Computing Platform: A Case Study From Nineveh Plain, Northern Iraq, Ali Za. Al-Ozeer, Alaa M. Al-Abadi, Tariq Abed Hussain, Alan E. Fryar, Biswajeet Pradhan, Abdullah Alamri, Khairul Nizam Abdul Maulud

Earth and Environmental Sciences Faculty Publications

Knowledge of the groundwater potential, especially in an arid region, can play a major role in planning the sustainable management of groundwater resources. In this study, nine machine learning (ML) algorithms—namely, Artificial Neural Network (ANN), Decision Jungle (DJ), Averaged Perceptron (AP), Bayes Point Machine (BPM), Decision Forest (DF), Locally-Deep Support Vector Machine (LD-SVM), Boosted Decision Tree (BDT), Logistic Regression (LG), and Support Vector Machine (SVM)—were run on the Microsoft Azure cloud computing platform to model the groundwater potential. We investigated the relationship between 512 operating boreholes with a specified specific capacity and 14 groundwater-influencing occurrence factors. The unconfined aquifer in …

Competition For Light In A Leucaena Leucocephala / Chloris Gayana Silvopastoral System, N. F. G. Rethman, J. P. Lindeque

IGC Proceedings (1977-2023)

The spatial variation in the vigour of Leucaena (Leucaena leucocephala cv. Cunningham) trees growing together with Rhodesgrass (Chloris gayana cv. Katambora) in an alley cropping system made it possible to assess the competitive effect for light. The height and especially lateral development of trees had a strong influence on light interception by the canopy, with radiation in the intercrop area being 49% lower where the trees were more vigorous. There was a corresponding (43%) decrease in grass production. These findings indicate that future studies should also include aspects such as espacement of trees, pruning of trees in the …

Optimizing Yield And Quality Of Orchardgrass Pasture In Temperate Silvipastoral Systems, P. L. Peri, R. J. Lucas, D. J. Moot, A. C. Varella, D. L. Mcneil

IGC Proceedings (1977-2023)

The objective of this study was to provide grazing management recommendations for a silvipastoral system by determining the effects of shade and nitrogen (N) on the pattern of dry matter accumulation and nutritive value of orchardgrass (Dactylis glomerata) in a subhumid temperate environment. Orchardgrass in open pasture (100% transmittance) and under 10 year old Pinus radiata tree shade (60% transmittance) at 200 stems/ha was used as the main plot and nitrogen (0 and 300 kg N/ha as synthetic urine) was the subplot factor. Dry matter (DM) production of orchardgrass in the first 60-day spring rotation was similar in …

Herbage Characteristics As Affected By The Canopies Of Dominant Trees In A Savanna Of Southern Mozambique, James P. Muir, A. Alage, Inacio C. Maposse

IGC Proceedings (1977-2023)

This study surveyed the species composition, forage yield and forage nitrogen concentration of the herbaceous layer 50, 100 and 200% of the canopy radius from the trunks of many-stemmed false thorn, knob thorn, scented thorn and marula trees in a southern Mozambican savanna. Tree species did not affect herbaceous DM yield or species diversity. Neither direction nor distance from the tree trunk affected DM or specific diversity. Crude protein percentages were 15% higher for legumes and 9% higher for grasses at 50% canopy than at 200% canopy. Grasses under the marulas, the only non-legume tree in the study, had 18% …

Selecting New Brachiaria For Brazilian Pastures, Cacilda B. Do Valle, Valéria P. B. Euclides, Manuel C. M. Macedo, José R. Valério, S. Calixto

IGC Proceedings (1977-2023)

Brazilian beef production relies heavily on cultivated pastures, of which about 80% are planted mainly to two Brachiaria cultivars. The narrowness of diversity associated with reproduction by apomixis of most plants in this genus prompted an intense search for new cultivars amongst recently collected and introduced ecotypes from Africa. This paper reports results for a three-year evaluation of 21 pre-selected ecotypes in two typical Cerrado ecosystems. Plots, replicated four times, were seeded in rows and cut every 6 weeks during the rainy season followed by a cut in the middle and one at the end of the dry season. Significant …

Aberrant Crosstalk Between Insulin Signaling And Mtor In Young Down Syndrome Individuals Revealed By Neuronal-Derived Extracellular Vesicles, Marzia Perluigi, Anna Picca, Elita Montanari, Riccardo Calvani, Federico Marini, Roberto Matassa, Antonella Tramutola, Alberto Villani, Giuseppe Familiari, Fabio Di Domenico, D. Allan Butterfield, Kenneth J. Oh, Emanuele Marzetti, Diletta Valentini, Eugenio Barone

Chemistry Faculty Publications

INTRODUCTION: Intellectual disability, accelerated aging, and early-onset Alzheimer-like neurodegeneration are key brain pathological features of Down syndrome (DS). Although growing research aims at the identification of molecular pathways underlying the aging trajectory of DS population, data on infants and adolescents with DS are missing.

METHODS: Neuronal-derived extracellular vesicles (nEVs) were isolated form healthy donors (HDs, n = 17) and DS children (n = 18) from 2 to 17 years of age and nEV content was interrogated for markers of insulin/mTOR pathways.

RESULTS: nEVs isolated from DS children were characterized by a significant increase in pIRS1^Ser636, a marker of …

Multi-Vendor And Multisite Evaluation Of Cerebrovascular Reactivity Mapping Using Hypercapnia Challenge, Peiying Liu, Dengrong Jiang, Marilyn Albert, Christopher E. Bauer, Arvind Caprihan, Brian T. Gold, Steven M. Greenberg, Karl G. Helmer, Kay Jann, Gregory A. Jicha, Pavel Rodriguez, Claudia L Satizabal, Sudha Seshadri, Herpreet Singh, Jeffrey F. Thompson, Danny J. J. Wang, Hanzhang Lu

Neuroscience Faculty Publications

Cerebrovascular reactivity (CVR), which measures the ability of cerebral blood vessels to dilate or constrict in response to vasoactive stimuli such as CO2 inhalation, is an important index of the brain's vascular health. Quantification of CVR using BOLD MRI with hypercapnia challenge has shown great promises in research and clinical studies. However, in order for it to be used as a potential imaging biomarker in large-scale and multi-site studies, the reliability of CO2-CVR quantification across different MRI acquisition platforms and researchers/raters must be examined. The goal of this report from the MarkVCID small vessel disease biomarkers consortium is to evaluate …