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Grassland In Ireland And The Uk, Myles Rath, S. Peel

IGC Proceedings (1977-2023)

Key points

1. Grassland is the dominant land use option in Ireland and the UK, and is characterised by a long growing season.

2. Dynamic, interactive systems of grassland management have been developed which combine high grass dry matter intakes with good sward quality. In the better grassland areas milk yields in excess of 7000 kg/cow are attainable with low levels of concentrate supplementation.

3. In the times to come, measures to protect the environment will constrain stocking rates, and fertiliser and manure use on intensive grassland enterprises.

4. A high proportion of beef and sheep farms participate in voluntary, …

Region-Based Analysis Of Rare Genomic Variants In Whole-Genome Sequencing Datasets Reveal Two Novel Alzheimer’S Disease-Associated Genes: Dtnb And Dlg2, Dmitry Prokopenko, Sanghan Lee, Julian Hecker, Kristina Mullin, Sarah Morgan, Yuriko Katsumata, Michael W. Weiner, David W. Fardo, Nan Laird, Lars Bertram, Winston Hide, Cristoph Lange, Rudolph E. Tanzi

Sanders-Brown Center on Aging Faculty Publications

Alzheimer’s disease (AD) is a genetically complex disease for which nearly 40 loci have now been identified via genome-wide association studies (GWAS). We attempted to identify groups of rare variants (alternate allele frequency <0.01) associated with AD in a region-based, whole-genome sequencing (WGS) association study (rvGWAS) of two independent AD family datasets (NIMH/NIA; 2247 individuals; 605 families). Employing a sliding window approach across the genome, we identified several regions that achieved association p values <10⁻⁶, using the burden test or the SKAT statistic. The genomic region around the dystobrevin beta (DTNB) gene was identified with the burden and SKAT test and replicated in case/control samples from the ADSP study reaching genome-wide significance after meta-analysis (p_meta= 4.74 × 10⁻⁸ ). SKAT analysis also revealed region-based association around the Discs large homolog 2 (DLG2) …

Single Center Retrospective Review Of Post-Laparotomy Ct Abdomen And Pelvis Findings And Trends, Dylan C. Steffey, Emad A. Chishti, Maximo J. Acevedo, Luis F. Acosta, James T. Lee

Radiology Faculty Publications

Purpose: To identify common findings visualized on CT following damage control laparotomy, including post-surgical changes and additional injuries, and to determine change in frequency of post-laparotomy CT at our institution over time.

Methods: Single institution, IRB-Exempt, retrospective review of the University of Kentucky trauma registry from 1/2006 to 2/2019 for all trauma patients undergoing exploratory laparotomy initially and subsequently undergoing CT of the abdomen and pelvis within 24 hours. Operative findings from surgical operation notes and findings reported on post-laparotomy CT were recorded, including vascular and solid organ injuries, operative changes, free intraperitoneal fluid/air, and retroperitoneal findings. Next steps in …

A Multi-Proxy Assessment Of The Impact Of Environmental Instability On Late Holocene (4500-3800 Bp) Native American Villages Of The Georgia Coast, Carey J. Garland, Victor D. Thompson, Matthew C. Sanger, Karen Y. Smith, Fred T. Andrus, Nathan R. Lawres, Katharine G. Napora, Carol E. Colaninno, J. Matthew Compton, Sharyn Jones, Carla S. Hadden, Alexander Cherkinsky, Thomas Maddox, Yi-Ting Deng, Isabelle H. Lulewicz, Lindsey Parsons

Anthropology Faculty Publications

Circular shell rings along the South Atlantic Coast of North America are the remnants of some of the earliest villages that emerged during the Late Archaic (5000-3000 BP). Many of these villages, however, were abandoned during the Terminal Late Archaic (ca 3800-3000 BP). We combine Bayesian chronological modeling with mollusk shell geochemistry and oyster paleobiology to understand the nature and timing of environmental change associated with the emergence and abandonment of circular shell ring villages on Sapelo Island, Georgia. Our Bayesian models indicate that Native Americans occupied the three Sapelo shell rings at varying times with some generational overlap. By …

Central Vs. Peripheral Vision During A Singe-Leg Drop Jump: Implications Of Dynamics And Patellofemoral Joint Stress, Junyoung Ko, Kyeongtak Song, Hoon Kim, Sae Yong Lee, Jihong Park

Athletic Training and Clinical Nutrition Faculty Publications

Landing on a single-leg without receiving direct visual information (e.g., not looking at the ground) may increase the risk of injury. We examined whether visual focus contributed to the changing lower-extremity dynamics and patellofemoral joint stress during a single-leg drop jump task. Twenty healthy volunteers visited the laboratory for three separate sessions. During each session, participants randomly performed either of two types of a single-leg drop jump task from a 30 cm high wooden box. Subsequently, participants looked at the landing spot (central vision condition) or kept their heads up (peripheral vision condition) when performing the task. Sagittal and frontal …

Preliminary Research On A Covid-19 Test Strategy To Guide Quarantine Interval In University Students, Jill M. Kolesar, Tyler Gayheart, Lance Poston, Eric Monday, Derek Forster, Elizabeth Belcher, Rani Jaiswal, J. Kirsten Turner, Donna K. Arnett, Eric B. Durbin, Joseph Monroe, Frank Romanelli, Susanne M. Arnold, C. Darrell Jennings, Heidi Weiss, Robert Dipaola

Pharmacy Practice and Science Faculty Publications

Following COVID-19 exposure, the Centers for Disease Control (CDC) recommends a 10–14-day quarantine for asymptomatic individuals and more recently a 7-day quarantine with a negative PCR test. A university-based prospective cohort study to determine if early polymerase chain reaction (PCR) negativity predicts day 14 negativity was performed. A total of 741 asymptomatic students in quarantine was screened and 101 enrolled. Nasopharyngeal swabs were tested on days 3 or 4, 5, 7, 10, and 14, and the proportion of concordant negative results for each day versus day 14 with a two-sided 95% exact binomial confidence interval was determined. Rates of concordant …

Neutron Stars With Baryon Number Violation, Probing Dark Sectors, Jeffrey M. Berryman, Susan Gardner, Mohammadreza Zakeri

Physics and Astronomy Faculty Publications

The neutron lifetime anomaly has been used to motivate the introduction of new physics with hidden-sector particles coupled to baryon number, and on which neutron stars provide powerful constraints. Although the neutron lifetime anomaly may eventually prove to be of mundane origin, we use it as motivation for a broader review of the ways that baryon number violation, be it real or apparent, and dark sectors can intertwine and how neutron star observables, both present and future, can constrain them.

A Measure Of Srs/Srt Plan Quality: Quantitative Limits For Intermediate Dose Spill (R50%) In Linac-Based Delivery, Dharmin D. Desai, Ivan L. Cordrey, Ellis L. Johnson

Radiation Medicine Faculty Publications

Stereotactic radiosurgery (SRS) and stereotactic radiotherapy (SRT) of multiple cranial targets using a single isocenter on conventional C-arm linear accelerators are rapidly developing clinical techniques. However, no universal guidelines for acceptable intermediate dose spill limits are currently available or widely accepted. In this work, we propose an intermediate dose spill guidance range for cranial SRS/SRT delivered on C-arm linacs with MLC collimation for single PTV plans and single isocenter multiple target plans with PTV volumes in the range 0.02–57.9 cm³. We quantify intermediate dose spill with the R50% metric (R50% = volume of 50% of prescription isodose cloud …

Combined Transhepatic And Transjugular Approach For Mechanical Thrombectomy Of Massive Tips Thrombosis, Jack B. Newcomer, Emad A. Chishti, Driss Raissi

Radiology Faculty Publications

Transjugular intrahepatic portosystemic shunt (TIPS) is a well-validated decompressive therapy option to manage ascites and variceal bleeding secondary to portal hypertension. Complications following TIPS procedures include hepatic encephalopathy, liver failure, and TIPS dysfunction. TIPS dysfunction is due to occlusion or stenosis of the TIPS shunt and can be caused by acute or chronic thrombosis. TIPS thrombosis is often treated with mechanical thrombectomy or catheter-directed thrombolytic therapy. Most cases of in-stent occlusion can be treated via a transjugular approach with recanalization or placement of additional stents. We present a case of a 72-year-old female who presented with worsening ascites 17 months …

Forage News [2022-03], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

No abstract provided.

Music Therapy In Us Corrections: Philosophy, Practice, And Protocols Of Music Therapists Working With Incarcerated People In The Us, Lorna E. Segall, Olivia S. Yinger

Music Faculty Publications

Although the United States has the highest incarceration rate in the world and music therapy has existed in U.S. correctional facilities for almost a century, little is known about music therapists who provide services to people who are incarcerated. Exploration in this area is important as it could help inform clinical practice, music therapy curriculum, and potentially influence policy in the treatment of inmates. This study explores the philosophy, practices, and protocols of music therapists working in the U.S. corrections system. Board-certified music therapists ( N = 542) completed an online survey in which they indicated their reasons for working …

Brain Barriers Virtual: An Interim Solution Or Future Opportunity?, Brianna M. Holder, Shaina E. Tolan, Kaleb K. Heinrich, Kaitlin C. Miller, Natalie Hudson, Geetika Nehra, Michelle E. Pizzo, Steffen E. Storck, William F. Elmquist, Britta Engelhardt, Irena Loryan, Michal Toborek, Bjoern Bauer, Anika M. S. Hartz, Brandon J. Kim

Biology Faculty Publications

Background: Scientifc conferences are vital communication events for scientists in academia, industry, and government agencies. In the brain barriers research feld, several international conferences exist that allow researchers to present data, share knowledge, and discuss novel ideas and concepts. These meetings are critical platforms for researchers to connect and exchange breakthrough fndings on a regular basis. Due to the worldwide COVID-19 pandemic, all in-person meetings were canceled in 2020. In response, we launched the Brain Barriers Virtual 2020 (BBV2020) seminar series, the frst stand-in virtual event for the brain barriers feld, to ofer scientists a virtual platform to present …

Computational Characterization Of Charge Transport Resiliency In Molecular Solids, Balaji Sesha Sarath Pokuri, Seab M. Ryno, Ramin Noruzi, Chad Risko, Baskar Ganapathysubramanian

Chemistry Faculty Publications

Organic semiconductors have found utility in a diverse array of applications. A key property impacting device performance is the charge transport mobility of the molecular solids making up the active layer in these devices. There is increasing interest in accessing, quantifying, and understanding the resilience of charge transport mobility to thermal, mechanical, and chemical perturbations in molecular solids. Here, we integrate molecular simulations with graph characterization to quantify the resilience of charge transport. We consider all-atom simulations of the PTB7 system and build on earlier graph approaches to rapidly characterize the charge mobility of the PTB7 molecular simulations. We introduce …

Determinantal Facet Ideals For Smaller Minors, Ayah Almousa, Keller Vandebogert

Mathematics Faculty Publications

A determinantal facet ideal (DFI) is generated by a subset of the maximal minors of a generic n× m matrix where n≤ m indexed by the facets of a simplicial complex Δ. We consider the more general notion of an r-DFI, which is generated by a subset of r-minors of a generic matrix indexed by the facets of Δ for some 1 ≤ r≤ n. We define and study so-called lcm-closed and unit interval r-DFIs, and show that the minors parametrized by the facets of Δ form a reduced Gröbner basis with respect to any term order for an lcm-closed …

Fill Materials At Integral End Bents, Charlie Sun, Tony Beckham

Kentucky Transportation Center Research Report

Jointless bridge designs have become increasingly popular due to their low construction and maintenance costs. But this design carries risks. Most notably, integral end bents can be displaced and undergo settlement due to soil movement in embankments and loads carried by the superstructure. In response, the Kentucky Transportation Cabinet (KYTC) devised a novel treatment for end bent and abutment backfills on low- and middle-span concrete bridges in which elasticized geofoam is placed between geosynthetically confined soil and an integral end bent (GCS-IEB). However, this design requires modification where the elasticized geofoam and overlying pavement meet. Using elasticized geofoam is also …

Electric Vehicles: Analysis Of Revenue Issues And Charging Station Implementation Plans, Chris Van Dyke, Bryan Gibson, Ryan Griffith, Andrew Martin, Jeeyen Koo, Doug Kreis

Kentucky Transportation Center Research Report

No abstract provided.

Apolipoprotein E Proteinopathy Is A Major Dementia-Associated Pathologic Biomarker In Individuals With Or Without The Apoe Epsilon 4 Allele, Jozsef Gal, Yuriko Katsumata, Haining Zhu, Sukanya Srinivasan, Jing Chen, Lance Allen Johnson, Wang-Xia Wang, Lesley Renee Golden, Donna M. Wilcock, Gregory A. Jicha, Matthew D. Cykowski, Peter Tobias Nelson

Spinal Cord and Brain Injury Research Center Faculty Publications

The amygdala is vulnerable to multiple or “mixed” mis-aggregated proteins associated with neurodegenerative conditions that can manifest clinically with amnestic dementia; the amygdala region is often affected even at earliest disease stages. With the original intent of identifying novel dementiaassociated proteins, the detergent-insoluble proteome was characterized from the amygdalae of 40 participants from the University of Kentucky Alzheimer’s Disease Center autopsy cohort. These individuals encompassed a spectrum of clinical conditions (cognitively normal to severe amnestic dementia). Polypeptides from the detergent-insoluble fraction were interrogated using liquid chromatography-electrospray ionization-tandem mass spectrometry. As anticipated, portions of peptides previously associated with neurologic diseases were …

Enhanced Immunoprecipitation Techniques For The Identification Of Rna-Binding Protein Partners: Igf2bp1 Interactions In Mammary Epithelial Cells, Saja A. Fakhraldeen, Scott M. Berry, David J. Beebe, Avtar Roopra, Celia M. Bisbach, Vladimir S. Spiegelman, Natalie M. Niemi, Caroline M. Alexander

Mechanical Engineering Faculty Publications

RNA-binding proteins (RBPs) regulate the expression of large cohorts of RNA species to produce programmatic changes in cellular phenotypes. To describe the function of RBPs within a cell, it is key to identify their mRNA-binding partners. This is often done by crosslinking nucleic acids to RBPs, followed by chemical release of the nucleic acid fragments for analysis. However, this methodology is lengthy, which involves complex processing with attendant sample losses, thus large amounts of starting materials and prone to artifacts. To evaluate potential alternative technologies, we tested “exclusion-based” purification of immunoprecipitates (IFAST or SLIDE) and report here that these methods …

Autologous Haematopoietic Stem Cell Transplantation And Systemic Sclerosis: Focus On Interstitial Lung Disease, Gianluca Bagnato, Antonio Giovanni Versace, Daniela La Rosa, Alberta De Gaetano, Egidio Imbalzano, Marianna Chiappalone, Carmelo Ioppolo, William Neal Roberts, Alessandra Bitto, Natasha Irrera, Alessandro Allegra, Giovanni Pioggia, Sebastiano Gangemi

Internal Medicine Faculty Publications

Autologous hematopoietic stem cells transplantation (AHSCT) has been employed as treatment for severe systemic sclerosis (SSc) with high risk of organ failure. In the last 25 years overall survival and treatment-related mortality have improved, in accordance with a better patient selection and mobilization and conditioning protocols. This review analyzes the evidence from the last 5 years for AHSCT-treated SSc patients, considering in particular the outcomes related to interstitial lung disease. There are increasing data supporting the use of AHSCT in selected patients with rapidly progressive SSc. However, some unmet needs remain, such as an accurate patient selection, pre-transplantation analysis to …

Estimation Of The Optimal Nitrogen Dose In A Brachiaria Humidicola-Corn Rotation System In The Colombian Eastern Plains, K. Enciso, S. Burkart

IGC Proceedings (1977-2023)

Improving nitrogen (N) use efficiency by optimizing the N fertilizer application dose is one way to reduce greenhouse gas (GHG) emissions in agriculture and livestock production, especially in higher demanding crops such as corn. Taking a Brachiaria humidicola (Bh)-corn rotation system in the Colombian Eastern Plains, we seek to determine both the optimal economic dose (OED) and the optimal technical dose (OTD) of N, which allow to maximize income at producer level and minimize environmental impacts. This particular rotation system was chosen as research subject given the presence of the residual effect of Biological Nitrogen Inhibition (BNI) in …

Screening And Breeding For Bermudagrass Stem Maggot (Bsm) Resistance Using U.S. Bermudagrass Germplasm, W. F. Anderson, D. Hancock, L. Baxter, W. Hudson, Esteban F. Rios

IGC Proceedings (1977-2023)

Bermudagrass (Cynodon sp.) is an important perennial forage grass grown in many parts of the world. Bermudagrass Stem Maggot (BSM) (Atherigona reversura Villeneuve) is an insect pest that reduces forage yield and nutritive value if it is not controlled. The pest, native to SE Asia, was first documented in North America in 2009 and is now considered invasive. A collection of over 300 forage bermudagrass accessions was evaluated in the field for susceptibility to BSM in 2014 and 2015. Tolerant lines and susceptible checks were then evaluated for yield loss due to BSM in a replicated field study …

Amplitude And Wavelength Scaling Of Sinusoidal Roughness Effects In Turbulent Channel Flow At Fixed ReΤ, Sparsh Ganju, Sean C. C. Bailey, Christoph Brehm

Mechanical Engineering Faculty Publications

Direct numerical simulations are performed for incompressible, turbulent channel flow over a smooth wall and different sinusoidal wall roughness configurations at a constant Re_τ = 720. Sinusoidal walls are used to study the effects of well-defined geometric features of roughness-amplitude, a, and wavelength, λ, on the flow. The flow in the near-wall region is strongly influenced by both a and λ. Establishing appropriate scaling laws will aid in understanding the effects of roughness and identifying the relevant physical mechanisms. Using inner variables and the roughness function to scale the flow quantities provides support for Townsend’s hypothesis, …

Glia Excitation In The Cns Modulates Intact Behaviors And Sensory-Cns-Motor Circuitry, Shelby Mccubbin, Douglas A. Harrison, Robin L. Cooper

Biology Faculty Publications

Glial cells play a role in many important processes, though the mechanisms through which they affect neighboring cells are not fully known. Insights may be gained by selectively activating glial cell populations in intact organisms utilizing the activatable channel proteins channel rhodopsin (ChR2XXL) and TRPA1. Here, the impacts of the glial-specific expression of these channels were examined in both larval and adult Drosophila. The Glia > ChR2XXL adults and larvae became immobile when exposed to blue light and TRPA1-expressed Drosophila upon heat exposure. The chloride pump expression in glia > eNpHR animals showed no observable differences in adults or larvae. In …

Body Condition Score Change Throughout Lactation Utilizing An Automated Bcs System: A Descriptive Study, Carissa M. Truman, Magnus R. Campler, Joao H. C. Costa

Animal and Food Sciences Faculty Publications

Body condition scoring (BCS) is a traditional visual technique often using a five-point scale to non-invasively assess fat reserves in cattle. However, recent studies have highlighted the potential in automating body condition scoring using imaging technology. Therefore, the objective was to implement a commercially available automated body condition scoring (ABCS) camera system to collect data for developing a predictive equation of body condition dynamics throughout the lactation period. Holstein cows (n = 2343, parity = 2.1 ± 1.1, calving BCS = 3.42 ± 0.24), up to 300 days in milk (DIM), were scored daily using two ABCS cameras mounted …

Non-Native Non-Apis Bees Are More Abundant On Non-Native Versus Native Flowering Woody Landscape Plants, Daniel A. Potter, Bernadette M. Mach

Entomology Faculty Publications

Urban ecosystems can support diverse communities of wild native bees. Because bloom times are conserved by geographic origin, incorporating some non-invasive non-native plants in urban landscapes can extend the flowering season and help support bees and other pollinators during periods when floral resources from native plants are limiting. A caveat, though, is the possibility that non-native plants might disproportionately host non-native, potentially invasive bee species. We tested that hypothesis by identifying all non-native bees among 11,275 total bees previously collected from 45 species of flowering woody landscape plants across 213 urban sites. Honey bees, Apis mellifera L., accounted for 22% …

What And Who Has Determined Adoption? A Study On Improved Forage Technologies In Colombia From An Agricultural Innovation System (Ais) Perspective, K. Enciso, N. Triana, M. Díaz, S. Burkart

IGC Proceedings (1977-2023)

The complex process behind the adoption of improved forages in Colombia remains largely unexplored. Despite governmental and scientific efforts to promote and disseminate the implementation of improved forages for the sake of sustainable livestock production, local livestock producers continue to extensively use native species and adoption rates of more efficient forages remain low. This study explores the dynamics behind the development and diffusion of improved forage technologies in Colombia, from the 1960's to the present through an Agricultural Innovation Systems (AIS) perspective. Here we map the agents involved, classify the roles they exerted over time and reconstruct the historical context …

From Theory To Practice: What Should We Have In Mind When Building Effective And Sustainable Payments For Ecosystem Services (Pes) Schemes For Silvo-Pastoral Systems? Evidence From Colombia, M. Díaz, K. Enciso, N. Triana, S. Burkart

IGC Proceedings (1977-2023)

In most Latin American countries, payment for ecosystem services (PES) can be a useful strategy for restoration and conservation of the environment, increasing productivity and promoting sustainable development in rural areas. Despite these plausible benefits, PES implementation can be challenging due to the contextual framework in which it takes place (e.g. institutional weakness in the implementation and monitoring stages, limited connectivity among stakeholders, low adoption levels of agricultural technology). This study aims at evaluating PES schemes for silvo-pastoral systems in Colombia by considering six dimensions based on an extensive literature review: policy and governance; social context; environmental context; risks and …

Smallholder Dairy Farmers In The Peruvian Andes Fulfilling The Role Of Extension Agents, C. S. Pinares-Patino, J. Manhire, R. Garcia Ticllacuri, J. L. Bernal Madrid, V. M. Velez Marroquin

IGC Proceedings (1977-2023)

Dairy farming in the Peruvian Andes is mostly undertaken by smallholder farmers (4-6 cows/family) and of relatively recent development. In fact, over the last 2 decades dairy farming at high altitudes (3,500‒4200 masl) has grown rapidly, replacing the camelids and sheep farming that once predominated. Dairying growth has been catalysed by subsides from state and private organizations. It promotes high input systems based on feedlot technology. Compared to sheep and camelids farming, dairying at the Andes does not have yet an inherent local/indigenous knowledge associated to it. High altitude Andean ecosystems pose many constraints for dairy farming (hypoxia and high …

Acetylsalicylic Acid Suppresses Alcoholism-Induced Cognitive Impairment Associated With Atorvastatin Intake By Targeting Cerebral Mirna155 And Nlrp3: In Vivo, And In Silico Study, Doaa I. Mohamed, Dalia Alaa El-Din Aly El-Waseef, Enas S. Nabih, Omnyah A. El-Kharashi, Hanaa F. Abd El-Kareem, Hebatallah H. Abo Nahas, Basel A. Abdel-Wahab, Yosra A. Helmy, Samar Zuhair Alshawwa, Essa M. Saied

Veterinary Science Faculty Publications

Alcoholism is one of the most common diseases that can lead to the development of several chronic diseases including steatosis, and cognitive dysfunction. Statins are lipid-lowering drugs that are commonly prescribed for patients with fatty liver diseases; however, the exact effect of statins on cognitive function is still not fully understood. In the present study, we have investigated the molecular and microscopic basis of cognitive impairment induced by alcohol and/or Atorvastatin (ATOR) administration to male Wistar albino rats and explored the possible protective effect of acetylsalicylic acid (ASA). The biochemical analysis indicated that either alcohol or ATOR or together in …

Pastoralists’ Perception Of Poverty: A Case Of The Somali And Turkana Of Northern Kenya, W. P. Watete, Kogi-Makau

IGC Proceedings (1977-2023)

Poverty is a complex phenomenon, without a single definition or standard methods of reducing it. Income based methods of assessing poverty have been shown to have limitations that undermine their application in measuring and attacking poverty among pastoral households. Stages of progress method of poverty assessment was used to assess poverty among pastoral households in Turkana and Mandera Counties of Northern Kenya. Three hundred and three hundred and fifty-four households in Mandera and Turkana Counties respectively were sampled across three different livelihood zones: pastoral, agro-pastoral and off-farm. Accumulation of livestock was regarded as a key indicator of wealth among pastoral …