Digital Commons Network^™

Assessment Of Hearing Health Among Adults In Rural Health Clinics, Mit A. Patel, David Adkins, Laura Bellnier, Anthony Mahairas, Matthew L. Bush

Otolaryngology--Head & Neck Surgery Faculty Publications

Objective: Hearing loss (HL) negatively impacts all aspects of health, yet poor access to hearing healthcare (HHC) among adults is a pervasive public health problem. The inaccessibility of HHC is amplified in rural adults. Rural health clinics (RHC) are a critical healthcare system tasked with improving health in rural communities and the objective of this study is to assess the prevalence of HL and the utilization of HHC within RHCs.

Methods: Using cross-sectional study design, adults were recruited from 10 RHC throughout rural Kentucky, mostly within Appalachia. The primary outcomes were (1) presence of HL on screening and (2) history …

Effects Of Constant Time Delay Using Multiple Acquisition Exemplars On The Generalization Of Self-Instruction To Complete Vocational Tasks For High School Students With Intellectual Disability, Anna Norby

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

This study presents findings from a multiple probe design that evaluated the effects of constant time delay with multiple acquisition exemplars on the acquisition and generalization of self-instruction to complete vocational tasks for high school students with intellectual disability. The research included three high school students with intellectual disability, and data were analyzed across baseline, intervention, and generalization conditions. Instruction targeted the use of self-instruction procedures embedded within vocational tasks, with multiple exemplars incorporated during acquisition to promote stimulus generalization. Participants were screened using a set of pre-arranged vocational tasks to identify existing skill levels and determine appropriate instructional targets, …

Evaluating Dosage Within A Rapid Caregiver Coaching Model, Emma L. Lovell

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

Rapid caregiver coaching models are designed to increase caregiver implementation of naturalistic language strategies while prioritizing feasibility for both families and providers. Participants of the current study were caregivers with young children (ages 1-4) with expressive language delays and autism risk or diagnosis. The current study took place in families’ homes and examined whether a predetermined number of brief coaching and feedback cycles was sufficient to produce clinically meaningful improvements in caregiver strategy use. Target behaviors for caregivers included play-based imitation and expansion, responsive language input, and structured teaching episodes designed to expand child communication. Results were variable but demonstrated …

Evaluating The Effects Of Abbreviated And Full-Length Training Formats On Implementation Of Embedded Instruction Practices, Hannah Elizabeth Keene

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

The purpose of this study was to evaluate the effects of an abbreviated training package and full-length behavioral skills training (BST) on staff implementation of embedded instruction (EI) procedures in a university-affiliated inclusive early childhood center. A nonconcurrent multiple baseline design across participants was used with four student workers in inclusive preschool classrooms. The initial intervention included a package of didactic instruction and in-vivo modeling. Full BST was planned for participants who did not reach mastery criteria following the brief training.

The primary dependent variable was participant fidelity of EI implementation, and the secondary dependent variable measured the rate of …

A Chandra View Of Spt-Cl J0217–5014: A Massive Galaxy Cluster At A Cosmic Intersection At Z = 0.53, Dan Hu, Shida Fan, Zhongsheng Yuan, Junjie Mao, Norbert Werner, Yuanyuan Su, François Mernier, Yuanyuan Zhao, Liyi Gu, Haiguang Xu

Physics and Astronomy Faculty Publications

Context. Galaxy clusters trace the densest regions of the cosmic web and are crucial laboratories for studying the thermodynamic and chemical evolution of the intracluster medium (ICM). The massive galaxy cluster SPT-CL J0217−5014 (z ∼ 0.53; M₅₀₀ ∼ 3 × 10¹⁴ M_⊙) is one of the Swift X-Ray Telescope serendipitous galaxy clusters with the highest reported Fe abundance (∼1.3 ± 0.4 Z_⊙ within ∼ 1_.^′7) and a potentially disturbed morphology.

Aims. SPT-CL J0217−5014 presents an intriguing opportunity to investigate ICM chemical enrichment and cool-core survival. With this study, we aim to …

A Uniform Analysis Of Gas-Phase Metallicity Evolution With 1–3 Gyr Time Sampling Over The Past 12 Gyr, Shweta Jain, Ryan L. Sanders, Ali Ahmad Khostova, Tucker Jones, Alice E. Shapley, Naveen Reddy, Alex M. Garcia, Paul Torrey, Alison L. Coil

Physics and Astronomy Faculty Publications

We present a systematic investigation of the evolution of the mass–metallicity relation (MZR) and fundamental metallicity relation (FMR) using uniform metallicity diagnostics across redshifts z ∼ 0 to z ∼ 3.3. We present new Keck/Deep Imaging Multi-Object Spectrograph measurements of the [O II]λλ3726, 3729 emission line doublet for star-forming galaxies at z ∼ 1.5 with existing measurements of redder rest-optical lines from the MOSFIRE Deep Evolution Field survey. These new observations enable uniform estimation of the gas-phase oxygen abundance using ratios of the [O II], Hβ, and [O III] lines for mass-binned samples of star-forming galaxies …

Energy Levels Of Multiscale Bound States From Qed Energy-Momentum Trace, Michael I. Eides, Vladimir A. Yerokhin

Physics and Astronomy Faculty Publications

Energy levels of quantum electrodynamics (QED) bound states, which depend on a number of independent mass parameters, can be calculated as matrix elements of the QED energy-momentum tensor trace. As an example of such system we consider muonic hydrogen. The leading one-loop corrections to its energy levels depend on the electron and muon masses. These corrections are calculated as matrix elements of the energy-momentum tensor trace. Respective one-loop trace diagrams are different from the standard Lamb shift diagrams. We explain analytically and diagrammatically why two different sets of diagrams lead to the same results. Similar relationships should also hold beyond …

Fe Xviii–Xxiv Kβ Inner-Shell Absorption Lines In The X-Ray Spectra Of Neutron Star And Black Hole Binaries With Xrism, Masahiro Tsujimoto, Daiki Miura, Hiroya Yamaguchi, Ehud Behar, Chris Done, María Díaz Trigo, Chamani M. Gunasekera, Peter A. M. Van Hoof, Stefano Bianchi, Maryam Dehghanian, Gary J. Ferland

Physics and Astronomy Faculty Publications

The advent of the X-ray microcalorimeter spectrometer Resolve onboard the XRISM space telescope opened a new era for high-resolution X-ray spectroscopy of astrophysical plasmas. Many spectral features were newly detected, including the Kα and Kβ inner-shell transition lines of mildly ionized (F- to Li-like) Fe at 6–8 keV in the spectra of X-ray binaries and active galactic nuclei. The widely used atomic databases contain information on the Kα but not Kβ lines of these ions. We conducted the atomic structure calculation using FAC to derive the Fe Kα and Kβ lines and verified the …

Cosmos Spectroscopic Redshift Compilation (First Data Release), Ali Ahmad Khostovan, Jeyhan S. Kartaltepe, Mara Salvato, Olivier Ilbert, Caitlin M. Casey, Hiddo Algera, Jacqueline Antwi-Danso, Andrew Battisti, Malte Brinch, Marcella Brusa, Antonello Calabrò, Peter L. Capak, Nima Chartab, Olivia R. Cooper, Isa G. Cox, Behnam Darvish, Nicole E. Drakos, Andreas L. Faisst, Matthew R. George, Ghassem Gozaliasl, Santosh Harish, Günther Hasinger, Hossein Hatamnia, Angela Iovino, Shuowen Jin, Daichi Kashino, Anton M. Koekemoer, Ronaldo Laishram, Khee Gan Lee, Jitrapon Lertprasertpong, Simon J. Lilly, Daizhong Liu

Physics and Astronomy Faculty Publications

We present the COSMOS Spectroscopic Redshift Compilation encompassing ∼20 yr of spectroscopic redshifts within a 10 deg² area centered on the 2 deg² COSMOS legacy field. This compilation contains 487,666 redshifts of 266,284 unique objects from 138 individual programs up to z ∼ 8 with median stellar mass ∼10^8.4-10¹⁰ M_⊙ (redshift dependent). Rest-frame NUVrJ colors and star formation rate-stellar mass correlations show that the compilation primarily contains low-to-intermediate-mass star-forming and massive, quiescent galaxies at z < 1.25 and mostly low-mass bursty star-forming galaxies at z > 2. Sources in the compilation cover a diverse range of environments, including protoclusters such as “Hyperion.” The full compilation …

The Aurora Survey, Danielle A. Berg, Ryan L. Sanders, Alice E. Shapley, Michael W. Topping, Naveen A. Reddy, Evan D. Skillman, Erik Aver, Fergus Cullen, Callum T. Donnan, James S. Dunlop, Tucker Jones, Ali Ahmad Khostovan, Derek J. Mcleod, Desika Narayanan, Pascal A. Oesch, Anthony J. Pahl, Max Pettini, N. M.Förster Schreiber, Daniel P. Stark

Physics and Astronomy Faculty Publications

We present the first robust helium (He) abundance measurements in star-forming galaxies at redshifts 1.6 ≲ z ≲ 3.3 using deep, moderate-resolution JWST/NIRSpec spectroscopy from the AURORA survey. We establish a high-z He sample consisting of 20 galaxies with multiple high-signal-to-noise-ratio (>5σ) He i emission-line detections, including the critical near-infrared λ10833 line. This is the first study at high redshift leveraging λ10833 to break degeneracies between temperature, electron density, optical depth, and He⁺/H⁺, enabling reliable He abundance determinations in the early Universe. We use a custom Markov Chain Monte Carlo framework incorporating direct-method electron temperature …

The Aurora Survey, Anthony J. Pahl, Alice Shapley, Naveen A. Reddy, Ryan Sanders, Michael W. Topping, Danielle A. Berg, Callum T. Donnan, James S. Dunlop, Richard S. Ellis, N. M. Förster Schreiber, K. Glazebrook, Derek J. Mcleod, Max Pettini, Daniel Schaerer

Physics and Astronomy Faculty Publications

We present ionizing photon production efficiencies (ξ_ion) for 63 z = 1.5–6.9 star-forming galaxies using precise nebular dust attenuation corrections from the JWST Assembly of Ultradeep Rest-optical Observations Revealing Astrophysics (AURORA) survey. A subset of objects within AURORA have individually determined nebular dust attenuation curves, which vary significantly in shape and normalization, resulting in reduced systematic uncertainty when constraining the total attenuation of Hα luminosity, and thus the intrinsic ionizing output within our sample. We find evidence for positive correlations between ξ_ion and redshift, equivalent width of [O iii] λ5007, and O32 = [O iii] λ5007/[O ii] …

The Relationship Between Warm And Hot Gas-Phase Metallicity In Massive Elliptical Galaxies And The Influence Of Active Galactic Nucleus Feedback, Valeria Olivares, Yuanyuan Su, Pasquale Temi, Ryan Eskenasy, Helen Russell, Massimo Gaspari, Philippe Salome, Francoise Combes, Ming Sun, Ezequiel Treister, Kevin Fogarty, Ana Jimenez-Gallardo, Patricio Lagos

Physics and Astronomy Faculty Publications

Context. Warm ionized gas is ubiquitous at the centers of X-ray bright elliptical galaxies. While it is believed to play a key role in the feeding and feedback processes of supermassive black holes, its origins remain under debate. Existing studies have primarily focused on the morphology and kinematics of warm ionized gas. Aims. This work aims to provide a new perspective on warm (∼10 000 K) ionized gas and its connection to X-ray-emitting hot gas (> 10⁶ K) by measuring and comparing their metallicities. Methods. We conducted a joint analysis of 13 massive elliptical galaxies using MUSE/VLT and Chandra …

Cooperative Charge Ordering Signature Of Trimer Molecules In Infinite-Layer Cacoo2, J. S. Lee, W. J. Kim, A. Khandelwal, K. T. Ko, H. Lee, C. T. Kuo, S. Song, C. Song, D. Jang, H. Choi, G. Park, S. Y. Park, G. Kang, H. Jang, P. Abdollahi, A. Seo, C. C. Kao, H. Y. Hwang

Physics and Astronomy Faculty Publications

The infinite-layer compound CaCoO₂ provides a compelling platform to explore how local orbital distortions evolve into collective electronic order. Using resonant soft x-ray scattering (RSXS) and its time-resolved counterpart (tr-RSXS), we reveal a cooperative coupling between two intertwined orders at the same in-plane wave vector, q≈(1/4,1/4,0), comprising a quasi-two-dimensional orbital order associated with the distorted Co(1) sites and a quasi-three-dimensional trimerlike charge order stabilized through Co-O-Ca hybridization. The charge-sensitive component exhibits a uniform relaxation time of ∼400 fs (391±5 fs) across multiple Co resonances, evidencing a collective charge response. A comparable timescale observed in the orbital order associated with …

Ultra-Sensitive Radon Assay Using An Electrostatic Chamber In A Recirculating System, A. Anker, P. A. Breur, B. Mong, P. Acharya, A. Amy, E. Angelico, I. J. Arnquist, A. Atencio, J. Bane, V. Belov, E. P. Bernard, T. Bhatta, A. Bolotnikov, J. Breslin, J. P. Brodsky, S. Bron, E. Brown, T. Brunner, B. Burnell, E. Caden, L. Q. Cao, G. F. Cao, D. Cesmecioglu, D. Chernyak, M. Chiu, R. Collister, T. Daniels, L. Darroch, R. Devoe, M. L. Di Vacri, Y. Y. Ding, M. J. Dolinski

Physics and Astronomy Faculty Publications

Rare event searches such as neutrinoless double beta decay and Weakly Interacting Massive Particle detection require ultra-low background detectors. Radon contamination is a significant challenge for these experiments, which employ highly sensitive radon assay techniques to identify and select low-emission materials. This work presents the development of ultra-sensitive electrostatic chamber (ESC) instruments designed to measure radon emanation in a recirculating gas loop, for future lower background experiments. Unlike traditional methods that separate emanation and detection steps, this system allows continuous radon transport and detection. This is made possible with a custom-built recirculation pump. A Python-based analysis framework, PyDAn, was developed …

The Rise Of Ionized Gas Filaments In Early-Type Galaxies, Ryan Eskenasy, Valeria Olivares, Yuanyuan Su

Physics and Astronomy Faculty Publications

Multiphase filamentary nebulae are ubiquitous in the brightest cluster galaxies (BCGs) of cool-core clusters, providing insight into baryon cycling and the feeding and feedback of supermassive black holes. However, BCGs account for less than 1% of all early-type galaxies (ETGs). To broaden our understanding of how multiphase filamentary nebulae form in ETGs and connect to the greater picture of galaxy evolution, it is crucial to explore ETGs that are outside of the dense centers of galaxy clusters or groups. We present VLT-MUSE IFU observations of 126 nearby non-central ETGs, detecting warm ionized gas in 62 of them. 35/62 host rotating …

German Couples' Mental And Relational Health Before, During, And After Pregnancy: Comparisons Across Conception Type, Mckenna Fey

Theses and Dissertations--Family Sciences

Previous research on the perinatal period (i.e., pregnancy and postpartum) has largely focused on the pregnant partner’s experience and has rarely involved dyadic data from both partners in a romantic relationship. Although mental health—particularly of pregnant partners—has been extensively studied, relational health is often overlooked in the literature. Using life course theory as a framework, the present study examines both pregnant and nonpregnant partners’ mental and relational health before, during, and after pregnancy to understand actor, partner, and cross-process effects. Six hundred and twelve couples (N = 1,224 individuals) from the German Family Panel (pairfam) were assessed for mental and …

Enhancing Team Science By Training Collaborative Biostatisticians To Have A Strong Statistical Voice, Gina-Maria Pomann, Steven C. Grambow, Marissa C. Ashner, Bibhas Chakraborty, Nan Liu, Megan L. Neely, Sarah Peskoe, Lacey Rende, Emily Slade, Tracy Truong, Lexie Zidanyue Yang, Greg P. Samsa, Jesse D. Troy

Biostatistics Faculty Publications

Strong statistical voice is defined as the ability to advocate and negotiate for good and ethical statistical practices, including integrating and resolving differing scientific approaches. This skill is crucial for biostatisticians who work on biomedical research teams, as it ensures the integrity and accuracy of statistical analyses and fosters productive collaborations with non-statisticians. Despite its importance, new graduates often lack targeted training opportunities. This manuscript presents a scalable training approach through the development of online videos. Preliminary didactic materials focused on two key applications: providing written comments on manuscripts and engaging in study design discussions. To evaluate this training approach, …

Exploring Relational Farming Futures For Responsible Innovation In Precision Agriculture Through Q-Method And Speculative Design, Bhavna Joshi, Maaz Gardezi, Edward Prutzer, Awais Hameed Khan, Asim Zia, Benjamin E. K. Ryan, Ali Dadkhah, Donna M. Rizzo, John T. Mcmaine, David Clay

Biosystems and Agricultural Engineering Faculty Publications

This article draws on concepts of speculative design and responsible innovation to examine the possible impacts of data-driven precision agriculture on farmers and farm work. We use an innovative mixed-method approach to research design. Using artistic depiction of futures of precision agriculture in design workshop and in-depth semistructured interviews conducted with the farmers in Vermont and South Dakota, we explain how farmers perceive different futures of precision agriculture. Specifically, in our design workshop, we combined visual arts and social science methods, namely Q-method, to explore existing and new relationships between humans, technologies, and environment in the design, deployment, and use …

Temporal Evolution Of Brain Inflammation In The Bilateral Common Carotid Artery Stenosis Model Of Chronic Cerebral Hypoperfusion, Makayla F. Cox, Jill M. Roberts, Ryan K. Shahidehpour, David L. Dornbos Iii, Adam D. Bachstetter

Neuroscience Faculty Publications

Chronic cerebral hypoperfusion is a major contributor to vascular cognitive impairment and dementia, primarily through its disruption of white matter integrity and promotion of neuroinflammatory cascades. The bilateral common carotid artery stenosis (BCAS) model has emerged as the predominant experimental approach for studying the effects of chronic cerebral hypoperfusion, particularly in aging-relevant contexts. This review synthesizes current knowledge of inflammatory responses in the BCAS model, with an emphasis on their temporal progression and functional consequences. We begin by outlining the clinical burden of hypoperfusion, the rationale for BCAS, and the hemodynamic phases it produces. We then examine early neurovascular unit …

Endocranial Morphological Affinities Of The Early Holocene Individuals From Lagoa Santa And Implications For The Peopling Of The Americas, María Clara López-Sosa, Hugo Reyes-Centeno, Lumila Paula Menéndez, Rodrigo Elias Oliveira, Claudio Campi De Castro, André Strauss

Anthropology Faculty Publications

The ectocranial morphology of early Holocene humans from Lagoa Santa, Brazil has been described as exhibiting a ‘Paleoamerican’ form with affinities to African and Australasian individuals, in contrast to past and present Native Americans, who predominantly exhibit ‘Amerindian’ form. While this interpretation remains disputed, its led to the ‘Two Main Biological Components Model’, which proposes separate dispersals from Asia into the Americas. This study aims to assess whether the endocranial morphology of Lagoa Santa individuals similarly reflects these affinities. For this study, the overall endocranial morphology, as well as the temporal bones of the crania of twenty individuals from Lagoa …

Factors Associated With Opioid-Involved Overdose: Descriptive Data From A Randomized Controlled Trial Evaluating Extended-Release Buprenorphine For Perinatal Opioid Use Disorder, Sara M. Witcraft, Leah Holcomb, Yingjia Wei, Gerald Cochran, John T. Winhusen, Michelle R. Lofwall, Peter R. Martin, Jessica L. Young, Jessica Spinali, Constance Guille

Center on Drug and Alcohol Research Faculty Publications

Background: Opioid use disorder (OUD) during pregnancy is a leading contributor to peripartum morbidity and mortality, with overdose deaths rising significantly in recent years. Despite the identification of various factors associated with overdose events, including social, demographic, psychiatric, and neonatal outcomes, the relative contributions of these factors to peripartum overdose history (or lack thereof) remain unclear. Thus, this study aims to characterize factors associated with lifetime opioid-involved overdose events among currently pregnant individuals receiving buprenorphine (BUP) treatment for OUD.   Methods: Treatment-seeking pregnant individuals with an estimated gestational age of 6 to 30 weeks were enrolled in a large multisite randomized …

Charge‐Governed Mechanistic Evaluation Of Aav2 Clarification Via Functionalized Flat Sheet And Hollow Fiber Deconstructed Depth Filters, Mara Baughman‐Leach, Mattie Brock, Malgorzata Chwatko, Dibakar Bhattacharyya

Chemical and Materials Engineering Faculty Publications

The expansion of adeno-associated virus (AAV)-based therapeutics has increased the demand for efficient clarification. In this study, a functionalized deconstructed depth filtration platform was developed to dissect how membrane–virus charge, modulated by pH, influences separation. Three charge regimes, positive (pH 4), neutral (pH 6), and negative (pH 8) between the membranes and AAVs, were examined. The flat-sheet system, composed of sequential 1.2, 0.8, 0.45, and 0.1 µm membranes, enabled the first layer-by-layer analysis of depth filtration behavior. This revealed that Stage 1 and Stage 4 dominate clarification. Remarkably, substantial DNA capture (> 75%) was observed even in the largest-pore stage, …

Brain-Derived Extracellular Vesicles Potentially Mediate Crosstalk With Peripheral Organs In Neurodegenerative Diseases, Ramzi H. Hamdalla, Vibha B. Bhaskar, Changhai Tian

Toxicology and Cancer Biology Faculty Publications

Brain-Derived Extracellular vesicles (BDEVs) are emerging mediators of intra- and interorgan communication in neurodegenerative diseases (NDs) such as Alzheimer’s Disease (AD) and Parkinson’s Disease (PD). A growing body of evidence suggests that BDEVs play an important role in modulating intercellular communication within the central nervous system in the pathogenesis of many NDs. By transporting non-coding RNAs (e.g., miRNAs) and important pathological proteins, BDEVs also influence peripheral organs and contribute to the progression of disease in the central nervous system (CNS). This review extends the understanding of NDs beyond solely brain dysfunction and gives a novel framework for the progression of …

Current Concepts In Hip And Core Assessment To Reduce The Risk Of Acl Injury, Jeremy M. Burnham, Anthony T. Drazick, Ghislain Aminake, Darren L. Johnson, Mary Lloyd Ireland, Brian W. Noehren

Orthopaedic Surgery and Sports Medicine Faculty Publications

Background: Hip and trunk (“core”) muscle dysfunction has emerged as a modifiable contributor to lower-limb biomechanics linked with non-contact anterior cruciate ligament (ACL) injuries. Clinicians increasingly target core stability and control during injury-prevention screening and post-operative rehabilitation programs; however, the literature lacks a focused synthesis of core-directed strategies for ACL injury mitigation. The purpose of this current concepts review is to synthesize current evidence on hip- and core-focused assessment and rehabilitation strategies that may mitigate ACL injury risk.

Design: Current Concepts Review.

Methods: A narrative search of PubMed and Google Scholar (January 2000 – April 2025) identified biomechanical, prospective, interventional, …

Feeding The Family—A Food Is Medicine Intervention: Preliminary Baseline Results Of Clinical Data From Caregivers And Children, Gabriela Drucker, Christa Mayfield, Elizabeth T. Anderson Steeves, Sara Maksi, Tabitha Underwood, Julie Brown, Marissa Frick, Alison Gustafson

Behavioral Science Faculty Publications

Background/Objectives: Food is Medicine (FIM) programs have been shown to be effective at addressing food and nutrition insecurity among individuals. However, more evidence is needed to determine effective interventions at the household level and their impact on child health outcomes. Feeding the Family is a randomized controlled trial which aims to determine whether the amount of food provided and the ability to select foods in FIM interventions have an incremental effect on child and caregiver clinical outcomes relative to nutrition counseling alone. The objective of this paper is to describe the population at baseline among those enrolled in Feeding the …

Formative Research To Identify Contributors To Risky Drinking And Adapt An Alcohol Reduction Intervention Among Young Adults Vulnerable To Hiv: Qualitative Focus Group Study, Fidelis Y. Sesenu, Sally Kirklewski, Bryce Takenaka, Jaime Brown, Erin Nicholson, Kimberly Haney, Kaylia Carroll, Arjee Restar, Donte Travon Boyd, Keisa Fallin-Bennett, Trace Kershaw, Carolyn Lauckner

Communication Faculty Publications

Background: Across populations, risky drinking has been demonstrated to increase HIV risk behaviors. This is of special concern for sexually minoritized cisgender men and gender-diverse young adults (aged 18‐34 years), who report greater incidence of hazardous drinking (as defined by the Alcohol Use Disorders Identification Test - Consumption criteria) and HIV compared to their heterosexual and/or cisgender peers.

Objective: This study aimed to examine alcohol perceptions, patterns of use, and the role that anti-LGBTQ+ (lesbian, gay, bisexual, transgender, queer) policies and discrimination played in alcohol risk behaviors for sexually minoritized cisgender men and gender-diverse individuals. Results were used to inform …

Social Engagement Moderates The Relationship Between Cognitive Functioning, Depressive Symptoms, And Restless Sleep In Older Black Adults, Sunkanmi Folorunsho, Olufunmilola Abraham, Darlingtina K. Esiaka

Pharmacy Practice and Science Faculty Publications

INTRODUCTION: Older Black adults face higher dementia risk, but it is unclear whether social engagement offsets the effects of depression and restless sleep.

METHODS: We analyzed 1,905 Black adults aged 50+ from the 2016-2020 Health and Retirement Study (HRS). Linear mixed-effects models tested how depressive symptoms, restless sleep, and social engagement predicted baseline cognition and cognitive decline.

RESULTS: Higher depressive symptoms and restless sleep were associated with lower baseline cognition (about 0.2 and 0.5 points lower) and faster decline (β×time ≈ −0.07 and −0.05). Greater social engagement predicted higher baseline cognition (about 0.6 points higher) and slower decline (β×time ≈ …

Validity And Reliability Of Force Insoles To Measure Center Of Pressure During Return-To-Sport Testing, Delaney Mcneese, Charles Eisner, Rachel Todd, Brian W. Noehren, Meredith K. Owen

Biomedical Engineering Faculty Publications

Center of pressure is a valuable biomechanical variable, predicting joint loading contributions during movement and giving insight into compensatory patterns. The purpose of this study was to assess the validity and reliability of force insoles in calculating vertical ground reaction force and center of pressure during return-to-sport jump testing. Ten healthy individuals performed double- and single-leg vertical and horizontal jumps on an instrumented treadmill while wearing instrumented force insoles. Vertical ground reaction force and anterior–posterior and medial–lateral center of pressure were collected at peak vertical ground reaction force from both devices. Repeat testing occurred 7 ± 5 days following the …

Non-Contact Optical Spectroscopy For Metabolic And Vascular Characterizations Of Orthotopic Tongue Cancer Models In Vivo, Md Zahid Hasan, Jing Yan, Sumit Sarker, Pranto Soumik Saha, Caigang Zhu

Biomedical Engineering Faculty Publications

Most tissue optical spectroscopy platforms use a fiber probe for light delivery and collection, while the inconsistent probe-sample contact could induce significant distortions in the measured optical signals, which consequently bring analysis errors. Moreover, it will be practically difficult to use a fiber probe for measurements in some cases such as oral cancer investigations using small animal models. To address the critical challenge, we report a portable, lens-based, optical spectroscopy device capable of quantifying key vascular and metabolic parameters in vivo without probe-sample contact. We combined lenses based diffuse reflectance and fluorescence spectroscopy into one portable platform to enable multi-parametric …

Combined Autofluorescence And Diffuse Reflectance Spectroscopy For Rapid Metabolic And Vascular Characterizations Of Orthotopic Tongue Tumors In Vivo, Pranto Soumik Saha, Jing Yan, Sumit Sarker, Zahid Hasan, Caigang Zhu

Biomedical Engineering Faculty Publications

Precise label-free quantification of tissue metabolic and vascular dynamics in vivo represents a critical challenge for cancer therapy prediction and longitudinal treatment assessment. In this study, we demonstrated a portable autofluorescence and diffuse reflectance spectroscopy device along with novel spectroscopic algorithms to quantify tissue vascular and metabolic parameters of orthotopic head and neck cancer models in vivo. Tissue-mimicking phantom studies were used to verify the dual-modal optical spectroscopy and easy-to-use spectroscopic algorithms for rapid and accurate estimation of tissue oxygen saturation, total hemoglobin contents, and intrinsic optical redox ratio. Animal studies were conducted to demonstrate the feasibility of our …