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Introducing Social Determinants Of Health To The Alzheimer's Disease Research Center Network, Megan Zuelsdorff, Erin L. Abner, Joyce E. Balls-Berry, Gregory A. Jicha, Serggio Lanata, Gladys E. Maestre, Monica Rosselli, Shana D. Stites, Rachel A. Whitmer, Consuelo H. Wilkins, Lisa L. Barnes May 2025

Introducing Social Determinants Of Health To The Alzheimer's Disease Research Center Network, Megan Zuelsdorff, Erin L. Abner, Joyce E. Balls-Berry, Gregory A. Jicha, Serggio Lanata, Gladys E. Maestre, Monica Rosselli, Shana D. Stites, Rachel A. Whitmer, Consuelo H. Wilkins, Lisa L. Barnes

Epidemiology and Environmental Health Faculty Publications

The Alzheimer's Disease Research Centers (ADRCs) consortium represents a critical locus of research on Alzheimer's disease and related disorders (ADRD) prevention, diagnosis, and intervention. Through the National Alzheimer's Coordinating Center's (NACC) standardized protocol, the Uniform Data Set (UDS), ADRCs have collected rich, harmonizable clinical and cognitive data. However, the collection of social data has been sparse and Center specific, constraining ADRD science that addresses research priorities on social determinants of health (SDOH) and health equity. Capitalizing on the transition to a revised UDS version 4, an interdisciplinary committee representing 10 ADRCs reviewed the literature and instrumentation, ultimately creating a brief …

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Beyond The Legislature’S Website: Strategies And Tools For State Legislative Research That Informs Advocacy Work, Jennifer Horne May 2025

Beyond The Legislature’S Website: Strategies And Tools For State Legislative Research That Informs Advocacy Work, Jennifer Horne

Library Faculty and Staff Publications

As the nation’s state legislatures increasingly decide the issues that affect citizens most directly, the ability to identify, track, and understand state legislation is key to successful advocacy efforts. While all state legislative websites provide the status and authoritative text of the bill, this may be insufficient to understand what the bill seeks to do and why the change is being proposed. To find plain English summaries and necessary context and background information on proposed bills, advocates may also need to find appropriate news sources and identify key stakeholders—those who care the most about the bill or are the most …

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On The Optimal Design Of Coreless Afpm Machines With Halbach Array Rotors For Electric Aircraft Propulsion, Matin Vatani, John F. Eastham, Xiaoze Pei, Dan M. Ionel May 2025

On The Optimal Design Of Coreless Afpm Machines With Halbach Array Rotors For Electric Aircraft Propulsion, Matin Vatani, John F. Eastham, Xiaoze Pei, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

This paper provides a comprehensive analysis of the winding factor and winding harmonic distribution in coreless stator axial flux permanent magnet (AFPM) machines. The topology of this type of machine and its similarities to conventional cored AFPM machines are discussed. Popular pole/coil number combinations in coreless stator AFPM machines are identified and analyzed in detail. It is demonstrated that the winding factor in these machines varies with radius and can be expressed as the product of the conductor distribution factor, pitch factor, and coil group factor. The formulas for each factor are derived and presented in multiple forms based on …

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Hybrid Fea And Meta-Modeling For De Optimization Of A Highly Saturated Spoke Ipm, Oluwaseun A. Badewa, Marcelo Silva, Rosemary E. Alden, Pedram Asef, Dan M. Ionel May 2025

Hybrid Fea And Meta-Modeling For De Optimization Of A Highly Saturated Spoke Ipm, Oluwaseun A. Badewa, Marcelo Silva, Rosemary E. Alden, Pedram Asef, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

This paper introduces a novel approach for high performance electric motor design that combines machine learning (ML)-based meta-modeling with a differential evolution (DE) optimization algorithm. The method leverages finite element analysis (FEA) results to train the ML meta-model, enabling efficient design optimization for high-power density cored machines, such as spoke interior permanent magnet motors (IPM), which exhibit complex nonlinearities and saturation effects. This hybrid ML-DE framework seeks to provide an alternative for physics-based electric motor design and optimization, offering significant reductions in computational effort while maintaining accuracy. The meta-model’s accuracy in capturing the nonlinear relationships between design parameters, core losses, …

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Optimal Design Of Coreless Axial Flux Pm Machines Using A Hybrid Machine Learning And Differential Evolution Method, Matin Vatani, David R. Stewart, Pedram Asef, Dan M. Ionel May 2025

Optimal Design Of Coreless Axial Flux Pm Machines Using A Hybrid Machine Learning And Differential Evolution Method, Matin Vatani, David R. Stewart, Pedram Asef, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

Coreless stator axial flux permanent magnet (AFPM) machines require computationally intensive three dimensional finite element analysis (FEA) for accurate performance evaluation, making optimization time-consuming and impractical for large-scale design studies. This paper presents a hybrid optimization approach that integrates differential evolution (DE) with artificial neural networks (ANNs) to accelerate the optimization of coreless AFPM machines. In this method, DE driven FEA simulations generate a dataset used to train an ANN surrogate model, significantly reducing reliance on direct FEA computations. The effectiveness of this approach is demonstrated through a multi-objective DE optimization, where the ANN’s predictions are validated against FEA results. …

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Winding Factors And Harmonics Of Coreless Axial Flux Pm Machines, Matin Vatani, John F. Eastham, Xiaoze Pei, Dan M. Ionel May 2025

Winding Factors And Harmonics Of Coreless Axial Flux Pm Machines, Matin Vatani, John F. Eastham, Xiaoze Pei, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

This paper provides a comprehensive analysis of the winding factor and winding harmonic distribution in coreless stator axial flux permanent magnet (AFPM) machines. The topology of this type of machine and its similarities to conventional cored AFPM machines are discussed. Popular pole/coil number combinations in coreless stator AFPM machines are identified and analyzed in detail. It is demonstrated that the winding factor in these machines varies with radius and can be expressed as the product of the conductor distribution factor, pitch factor, and coil group factor. The formulas for each factor are derived and presented in multiple forms based on …

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Resistance Exercise And Mechanical Overload Upregulate Vimentin For Skeletal Muscle Remodeling, Joshua S. Godwin, J. Max Michel, Cleiton A. Libardi, Andreas N. Kavazis, Christopher S. Fry, Andrew D. Frugé, Mariah Mccashland, Ivan J. Vechetti, John J. Mccarthy, C. Brooks Mobley, Michael D. Roberts May 2025

Resistance Exercise And Mechanical Overload Upregulate Vimentin For Skeletal Muscle Remodeling, Joshua S. Godwin, J. Max Michel, Cleiton A. Libardi, Andreas N. Kavazis, Christopher S. Fry, Andrew D. Frugé, Mariah Mccashland, Ivan J. Vechetti, John J. Mccarthy, C. Brooks Mobley, Michael D. Roberts

Physiology Faculty Publications

We adopted a proteomic and follow-through approach to investigate how mechanical overload (MOV) potentially affects novel targets in skeletal muscle, and how a perturbation in this response could potentially affect the adaptive response. First, we determined that 10 wk of resistance training in 15 college-aged females increased sarcolemmal-associated protein content (+10.1%, P < 0.05). Sarcolemmal protein isolates were then queried using mass spectrometry-based proteomics, ∼10% (38/387) of proteins putatively associated with the sarcolemma or extracellular matrix (ECM) were upregulated (>1.5-fold, P < 0.05), and one target (intermediate filament vimentin; VIM) warranted further investigation due to its correlation to myofiber hypertrophy (r = 0.652, P = 0.009). VIM expression was then examined in 4-mo-old C57BL/6J mice following 10 and 20 days of plantaris MOV via synergist ablation. Relative to Sham (control) mice, VIM mRNA and protein content was significantly higher in MOV mice, and immunohistochemistry indicated that VIM predominantly resided in the ECM. MOV experiments were replicated in Pax7-DTA (satellite cell depleted) mice, which reduced VIM in the ECM by ∼74%. A third MOV experiment was performed in C57BL/6 mice intramuscularly injected with either AAV9-scrambled (control) or AAV9-VIM-shRNA. Although VIM-shRNA mice possessed lower VIM in the ECM (∼45%), plantaris masses in response to MOV were similar between groups. However, VIMshRNA mice possessed smaller and more centrally nucleated MyHCemb-positive fibers in response to MOV. In summary, skeletal muscle VIM appears to be enriched in the ECM following MOV, satellite cells may regulate its expression, and a disruption in expression during MOV leads to an excessive regenerative phenotype.

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Temporal Immune Profiling In The Cerebrospinal Fluid And Blood Of Patients With Aneurysmal Subarachnoid Hemorrhage, Thomas A. Ujas, Katie L. Anderson, Jenny Lutshumba, Samantha N. Hart, Jadwiga Turchan-Cholewo, Kevin W. Hatton, Adam D. Bachstetter, Barbara S. Nikolajczyk, Ann M. Stowe May 2025

Temporal Immune Profiling In The Cerebrospinal Fluid And Blood Of Patients With Aneurysmal Subarachnoid Hemorrhage, Thomas A. Ujas, Katie L. Anderson, Jenny Lutshumba, Samantha N. Hart, Jadwiga Turchan-Cholewo, Kevin W. Hatton, Adam D. Bachstetter, Barbara S. Nikolajczyk, Ann M. Stowe

Surgery Faculty Publications

Delayed cerebral ischemia (DCI) is a significant complication of aneurysmal subarachnoid hemorrhage (aSAH). This study profiled immune responses after aSAH and evaluated their association with DCI onset. Twelve aSAH patients were enrolled. Leukocyte populations and cytokine levels were analyzed in cerebrospinal fluid (CSF) and peripheral blood (PB) on days 3, 5, 7, 10, and 14 post-aSAH. PB mononuclear cells (PBMCs) were collected, and their cytokine production quantified following stimulation. Mixed-effects models reveal distinct immune cell dynamics in CSF compared with blood. Monocyte/macrophage numbers continue to increase in both CSF and PBMCs for days post-aSAH. CD4+ human leukocyte antigen II+ …

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Training, Validating, And Testing Machine Learning Prediction Models For Endometrial Cancer Recurrence, Jesus Gonzalez Bosquet, Andrew Polio, Erin George, Ahmad A. Tarhini, Casey M. Cosgrove, Marilyn S. Huang, Bradley Corr, Aliza L. Leiser, Bodour Salhia, Kathleen Darcy, Christopher M. Tarney, Rob L. Dood, Lauren E. Dockery, Stephen B. Edge, Michael J. Cavnar, Lisa Landrum, Rob J. Rounbehler, Michelle Churchman, Vincent M. Wagner May 2025

Training, Validating, And Testing Machine Learning Prediction Models For Endometrial Cancer Recurrence, Jesus Gonzalez Bosquet, Andrew Polio, Erin George, Ahmad A. Tarhini, Casey M. Cosgrove, Marilyn S. Huang, Bradley Corr, Aliza L. Leiser, Bodour Salhia, Kathleen Darcy, Christopher M. Tarney, Rob L. Dood, Lauren E. Dockery, Stephen B. Edge, Michael J. Cavnar, Lisa Landrum, Rob J. Rounbehler, Michelle Churchman, Vincent M. Wagner

Surgery Faculty Publications

PURPOSEEndometrial cancer (EC) is the most common gynecologic cancer in the United States with rising incidence and mortality. Despite optimal treatment, 15%-20% of all patients will recur. To better select patients for adjuvant therapy, it is important to accurately predict patients at risk for recurrence. Our objective was to train, validate, and test models of EC recurrence using lasso regression and other machine learning (ML) and deep learning (DL) analytics in a large, comprehensive data set.METHODSData from patients with EC were downloaded from the Oncology Research Information Exchange Network database and stratified into low risk, The International Federation of Gynecology …

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Outcomes Associated With Absent Blood Product Utilization In Jehovah’S Witness Patients Compared To The Standard Of Care In Cardiac Surgery, Nathan Fields, Ayesha Ather, Dan Davenport, Sadiq Ahmed, Michael Sekela May 2025

Outcomes Associated With Absent Blood Product Utilization In Jehovah’S Witness Patients Compared To The Standard Of Care In Cardiac Surgery, Nathan Fields, Ayesha Ather, Dan Davenport, Sadiq Ahmed, Michael Sekela

Surgery Faculty Publications

Introduction: For Jehovah’s Witness (JW) patients requiring cardiac surgery, various strategies such as preoperative use of erythropoietin stimulating agents (ESAs), intravenous iron (IVI), and non-pharmacologic interventions have emerged to prevent complications from blood loss given transfusion is not acceptable in this population. Methods: Retrospective case-control of cardiac surgeries performed by the same surgeon between 1/1/2011 and 8/30/2021. JW patients were matched to non-JW who received blood products and non-JW who did not receive blood products on a 1:2:2 basis. Patients were matched on procedure, age, gender, and Society of Thoracic Surgeons morbidity score. Eligible patients were aged >18 years and …

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The Alzheimer's Biomarker Consortium–Down Syndrome (Abc-Ds), Benjamin L. Handen, Mark Mapstone, Sigan Hartley, Howard Andrews, Brad Christian, Joseph H. Lee, Dana Tudorascu, Christy Hom, Beau M. Ances, Shahid Zaman, Sharon Krinsky-Mchale, Adam M. Brickman, H. Diana Rosas, Annie Cohen, Melissa Petersen, Sid O'Bryant, Jordan P. Harp, Frederick Schmitt, Lauren Ptomey, Jeffrey Burns, Ira T. Lott, Florence Lai, Wayne Silverman, Charles Laymon, Elizabeth Head May 2025

The Alzheimer's Biomarker Consortium–Down Syndrome (Abc-Ds), Benjamin L. Handen, Mark Mapstone, Sigan Hartley, Howard Andrews, Brad Christian, Joseph H. Lee, Dana Tudorascu, Christy Hom, Beau M. Ances, Shahid Zaman, Sharon Krinsky-Mchale, Adam M. Brickman, H. Diana Rosas, Annie Cohen, Melissa Petersen, Sid O'Bryant, Jordan P. Harp, Frederick Schmitt, Lauren Ptomey, Jeffrey Burns, Ira T. Lott, Florence Lai, Wayne Silverman, Charles Laymon, Elizabeth Head

Psychology Faculty Publications

INTRODUCTION: Virtually all adults with Down syndrome (DS) will accumulate the neuropathologies associated with Alzheimer's disease (AD) by age 40, with the majority having a clinical dementia diagnosis by their middle 50s. METHODS: This paper complements a 2020 publication describing the Alzheimer's Biomarker Consortium–Down Syndrome (ABC-DS) methodology by highlighting protocol changes since initial funding in 2015. It describes available clinical, neuropsychological, neuroimaging, and biofluid data and bio-specimen repository. Ten years of accomplishments are summarized. RESULTS: Over 500 adults with DS and 59 sibling controls have been enrolled since 2015 with nearly 800 follow-up visits. More than 900 magnetic resonance imaging …

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Consumer Perceptions Of Hemp-Fed Aquaculture, Jillian Hyink, Brandon R. Mcfadden, Saroj Adhikari, Brandy E. Phipps, Tyler Mark, Waldemar Rossi, Craig Schluttenhofer, Seong D. Yun Apr 2025

Consumer Perceptions Of Hemp-Fed Aquaculture, Jillian Hyink, Brandon R. Mcfadden, Saroj Adhikari, Brandy E. Phipps, Tyler Mark, Waldemar Rossi, Craig Schluttenhofer, Seong D. Yun

Agricultural Economics Faculty Publications

Global demand for seafood has increased significantly in recent decades and is projected to continue rising. Aquaculture production has increased in the United States and globally to meet this demand, offering a relatively sustainable supplement to wild fish supplies. However, increased production further strains natural populations of pelagic species used to make fishmeal and fish oil into feedstocks, raising production costs and introducing safety concerns associated with fish consumption. A potential alternative feed ingredient is hemp, which can provide a cost-effective and nutritious feed for carnivorous fish. Moreover, hemp could meet the requirements for the final product to carry a …

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Tolerance Of Homonegativity And Transnegativity Predicts Negative Evaluations Of Lgbt People And Lgbt-Supportive Policies Among Us-Based Heterosexual, Cisgender Participants, Abigail M. Folberg, Jennifer S. Hunt, Ellen D. B. Riggle Apr 2025

Tolerance Of Homonegativity And Transnegativity Predicts Negative Evaluations Of Lgbt People And Lgbt-Supportive Policies Among Us-Based Heterosexual, Cisgender Participants, Abigail M. Folberg, Jennifer S. Hunt, Ellen D. B. Riggle

Gender and Women's Studies Faculty Publications

Many people in the United States express anti-LGBT attitudes and oppose LGBT rights. These views are perpetuated when others, including allies, tolerate expressions of anti-LGBT bias. In this study, we adapted and validated a measure of tolerance of homonegativity and transnegativity (TOHT), and assessed its associations with evaluations of LGBT people, straight people, support for LGBT rights, and system-justifying ideologies among heterosexual, straight, binary-gendered/non-trans (i.e., cisgender) women and men who identified as liberal, moderate, or conservative (N = 295). Participants completed measures of TOHT, evaluations of LGBT people, support for LGBT rights, authoritarianism, religiosity, and contact with LGBT people. Analyses …

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Smart Home Hvac Digital Twin Ml Meta-Model For Electric Power Distribution Systems With Solar Pv And Cta-2045 Controls, Rosemary E. Alden, Evan S. Jones, Steven B. Poore, Dan M. Ionel Apr 2025

Smart Home Hvac Digital Twin Ml Meta-Model For Electric Power Distribution Systems With Solar Pv And Cta-2045 Controls, Rosemary E. Alden, Evan S. Jones, Steven B. Poore, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

Building modeling, specifically heating, ventilation, and air conditioning (HVAC) load and equivalent energy storage calculations, represent a key focus for decarbonization of buildings and smart grid controls. In this paper, an ultra-fast one minute resolution Hybrid Machine Learning Model (HMLM) is proposed as part of a novel contribution in the field of residential physics-based smart home surrogate modeling. Emulation of white box models, or digital twins, with editable parameters through machine learning (ML) meta-modeling serves as an alternative to wide-spread experimental big data collection. The HMLM employs combined k-means clustering with multiple linear regression (MLR) to emulate minutely HVAC power …

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Mo-Substitution In V2O5 Tunes The Structure Towards Three-Dimensional Connectivity And Improves Li-Ion Battery Cycling, Kausturi Parui, Bonnie G. Gardner, Kathryn A. Pitton, Noah G. Caracuel, Emily Vidal-Torres, Shornam Gandhi, Beth S. Guiton, Juan C. Nino, Megan M. Butala Apr 2025

Mo-Substitution In V2O5 Tunes The Structure Towards Three-Dimensional Connectivity And Improves Li-Ion Battery Cycling, Kausturi Parui, Bonnie G. Gardner, Kathryn A. Pitton, Noah G. Caracuel, Emily Vidal-Torres, Shornam Gandhi, Beth S. Guiton, Juan C. Nino, Megan M. Butala

Chemistry Faculty Publications

The development of alternative energy sources is crucial for reducing reliance on fossil fuels, particularly for mobile applications such as personal electronics and transportation. This necessitates the advancement of battery materials based on abundant and inexpensive constituent elements. To achieve this requires investigating materials in a broader compositional and structural design space. Early transition metal oxides, including the intercalation electrode α − V2O5, however, the performance of V2O5 is hindered by phase transformations during battery cycling that lead to capacity fade and short device lifetimes. This study investigates the modification of V2 …

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Novel Approaches To Analyze Consumer Behavior And Policies To Promote Sustainable Consumption, Bhagyashree Katare, Xuejian Wang, Shuoli Zhao, Jacqueline Yenerall Apr 2025

Novel Approaches To Analyze Consumer Behavior And Policies To Promote Sustainable Consumption, Bhagyashree Katare, Xuejian Wang, Shuoli Zhao, Jacqueline Yenerall

Agricultural Economics Faculty Publications

Technological advancements, such as online grocery shopping, have significantly transformed consumer retail environments and experiences. Effectively studying consumer behavior in these new environments requires the use of novel methodological approaches, which will also aid in developing interventions to encourage sustainable consumption. This paper begins by providing an overview of the current literature on novel approaches to analyzing consumer behavior, then provides an empirical application by examining consumer decision-making pathways within an online grocery shopping platform. Specifically, the paper focuses on exploring the consumers’ digital footprints, such as page visits, product additions and removals, and interactions with information labels to identify …

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Candidates Be Posting, Josephine Lukito, Maggie Macdonald, Bin Chen, Megan A. Brown, Stephen Prochaska, Yunkang Yang, Jason Greenfield, Jiyoun Suk, Wei Zhong, Ross Dahlke, Porismita Borah Apr 2025

Candidates Be Posting, Josephine Lukito, Maggie Macdonald, Bin Chen, Megan A. Brown, Stephen Prochaska, Yunkang Yang, Jason Greenfield, Jiyoun Suk, Wei Zhong, Ross Dahlke, Porismita Borah

Political Science Faculty Publications

In this multi-platform, comparative study, we analyze social media messages from political candidates (N = 1,517) running for Congress during the 2022 U.S. Midterm election. We collect data from seven social media platforms: Facebook, Twitter, Truth Social, Gettr, Instagram, YouTube, and Rumble over the 4 weeks before and after election day. With this unique dataset of posts, we apply computational methods to identify messages that sought to mobilize individuals (online and offline) to donate money, vote, attend events, engage with the campaign online, and visit the campaign’s content on other platforms. We find that Democrats were not on alt-tech platforms …

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The Price Of Justice, Jillienne Haglund, Francesca Parente Apr 2025

The Price Of Justice, Jillienne Haglund, Francesca Parente

Political Science Faculty Publications

What factors explain compliance with monetary damages awarded by the Inter-American Court of Human Rights (IACtHR)? States comply with the payment of monetary damages at higher rates than other forms of reparation. However, the higher compliance rate belies the significant variation in time to compliance with the payment of monetary awards. We identify three case-level characteristics that explain this variation: size of awards, number of victims, and victim identity. We test our hypotheses utilizing original datasets on compliance with monetary damages and case characteristics in IACtHR judgments through 2019, and find support for all three factors on time to compliance.

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Steroid Receptors And Coregulators: Dissemination Of Sex Differences And Emerging Technologies, Sally Pauss, Evelyn A. Bates, Genesee J. Martinez, Zane T. Bates, Zachary A. Kipp, Cassandra D. Gipson, Terry D. Hinds Jr. Apr 2025

Steroid Receptors And Coregulators: Dissemination Of Sex Differences And Emerging Technologies, Sally Pauss, Evelyn A. Bates, Genesee J. Martinez, Zane T. Bates, Zachary A. Kipp, Cassandra D. Gipson, Terry D. Hinds Jr.

Markey Cancer Center Faculty Publications

Steroid receptors are ligand-induced transcription factors that have broad functions among all living animal species, ranging from control of sex differences, body weight, stress responses, and many others. Their binding to coregulator proteins is regulated by corepressors and coactivators that interchange upon stimulation with a ligand. Coregulator proteins are an imperative and understudied aspect of steroid receptor signaling. Here, we discuss steroid receptor basics from protein domain structures that allow them to interact with coregulators and other proteins, their essential functions as transcription factors, and other elemental protein–protein interactions. We deliberate about the mechanisms that coregulators control in steroid receptor …

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Lysyl Hydroxylase 2 Glucosylates Collagen Vi To Drive Lung Cancer Progression, Shike Wang, Houfu Guo, Reo Fukushima, Masahiko Terajima, Min Liu, Guan-Yu Xiao, Lenka Koudelková, Chao Wu, Xin Liu, Jiang Yu, Emma Burris, Jun Xu, Alvise Schiavinato, William K. Russell, Mitsuo Yamauchi, Xiaochao Tan Apr 2025

Lysyl Hydroxylase 2 Glucosylates Collagen Vi To Drive Lung Cancer Progression, Shike Wang, Houfu Guo, Reo Fukushima, Masahiko Terajima, Min Liu, Guan-Yu Xiao, Lenka Koudelková, Chao Wu, Xin Liu, Jiang Yu, Emma Burris, Jun Xu, Alvise Schiavinato, William K. Russell, Mitsuo Yamauchi, Xiaochao Tan

Markey Cancer Center Faculty Publications

Lysyl hydroxylase 2 (LH2) is highly expressed in multiple tumor types and accelerates disease progression by hydroxylating lysine residues on fibrillar collagen telopeptides to generate stable collagen cross links in tumor stroma. Here, we show that a galactosylhydroxylysyl glucosyltransferase (GGT) domain on LH2 modified type-VI collagen (Col6) to promote lung adenocarcinoma (LUAD) growth and metastasis. In tumors generated by LUAD cells lacking LH2 GGT domain activity, stroma was less stiff, and stable types of collagen cross links were reduced. Mass spectrometric analysis of total and glycosylated peptides in parental and GGT-inactive tumor samples identified Col6 chain α3 (Col6a3), a component …

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Characterization Of Tnsalp Expression And Activity In Porcine Utero-Placental Tissues, Claire Stenhouse, Nirvay Sah, Katherine M. Halloran, Robyn M. Moses, Makenzie G. Newton, Joe W. Cain, Heewon Seo, Guoyao Wu, Gregory A. Johnson, Fuller W. Bazer Apr 2025

Characterization Of Tnsalp Expression And Activity In Porcine Utero-Placental Tissues, Claire Stenhouse, Nirvay Sah, Katherine M. Halloran, Robyn M. Moses, Makenzie G. Newton, Joe W. Cain, Heewon Seo, Guoyao Wu, Gregory A. Johnson, Fuller W. Bazer

Animal and Food Sciences Faculty Publications

Abstract: Tissue non-specific alkaline phosphatase (TNSALP) regulates postnatal phosphate homeostasis, but its role in utero-placental phosphate availability remains poorly understood. Gilts were bred and hysterectomized on Day 60 or Day 90 of gestation (n = 6/day). Phosphate was less abundant in allantoic and amniotic fluids on Day 90 compared to Day 60. TNSALP protein was immunolocalized, and enzymatic activity was quantified and localized in endometrial and chorioallantois tissues. Day had no effect on TNSALP activity in the chorioallantois. In contrast, endometrial TNSALP activity was lower on Day 90 compared to Day 60. Phosphate abundance in allantoic fluid correlated positively with …

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Separation And Quantification Of Mycotoxins In Floral Tissue Of Hemp (Cannabis Sativa) Infected With Fusarium Graminearum, Isabelle A. Kagan, Henry S. Smith, Rachel R. Schendel, Nicole Gauthier Apr 2025

Separation And Quantification Of Mycotoxins In Floral Tissue Of Hemp (Cannabis Sativa) Infected With Fusarium Graminearum, Isabelle A. Kagan, Henry S. Smith, Rachel R. Schendel, Nicole Gauthier

Animal and Food Sciences Faculty Publications

Background: The fungal pathogen Fusarium graminearum produces mycotoxins when it infects grains. This pathogen also infects hemp (Cannabis sativa L. containing less than 0.3% tetrahydrocannabinol or THC). The presence of trichothecene mycotoxins like deoxynivalenol (DON) has not been reported in floral tissue of hemp infected with F. graminearum. The object of this study was to develop a method to extract three trichothecene mycotoxins—DON, 3-acetyldeoxynivalenol (3-ADON), and 15-acetyldeoxynivalenol (15-ADON)—from hemp floral tissue, and to quantify the mycotoxins by high-performance liquid chromatography (HPLC) with ultraviolet detection. Results: Standards of nivalenol (NIV), DON-3-glucoside (D3G), DON, 3-ADON, and 15-ADON were separated from each other …

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Longitudinal Investigation Of Gait And Alzheimer's Disease In Adults With Down Syndrome, Ashlyn Barry, Jamie C. Peven, Benjamin L. Handen, Daniel Bolt, Sharon J. Krinsky-Mchale, Christy L. Hom, Isabel C.H. Clare, Amanda Glueck, Jordan Harp, Frederick Schmitt, Matthew Zammit, Davneet Minhas, Weiquan Luo, Charles Laymon, Julie Price, Joseph H. Lee, Ira Lott, Annie Cohen, Beau M. Ances, Margaret Pulsifer, H. Diana Rosa, Florencia Lai, Shahid H. Zaman, Elizabeth Head, Mark Mapstone, Bradley T. Christian, Sigan L. Hartley Apr 2025

Longitudinal Investigation Of Gait And Alzheimer's Disease In Adults With Down Syndrome, Ashlyn Barry, Jamie C. Peven, Benjamin L. Handen, Daniel Bolt, Sharon J. Krinsky-Mchale, Christy L. Hom, Isabel C.H. Clare, Amanda Glueck, Jordan Harp, Frederick Schmitt, Matthew Zammit, Davneet Minhas, Weiquan Luo, Charles Laymon, Julie Price, Joseph H. Lee, Ira Lott, Annie Cohen, Beau M. Ances, Margaret Pulsifer, H. Diana Rosa, Florencia Lai, Shahid H. Zaman, Elizabeth Head, Mark Mapstone, Bradley T. Christian, Sigan L. Hartley

Psychology Faculty Publications

INTRODUCTION: Gait abnormalities are associated with Alzheimer's disease (AD) in the general population, but it is unclear if the same is true for individuals with Down syndrome (DS). This study examined gait across 32 months in relation to neuroimaging biomarkers (amyloid beta [Aβ], neurofibrillary tangles [NFTs], and hippocampal volume), cognitive decline, and clinical AD status in adults with DS. METHODS: Participants were 218 adults with DS who underwent Aβ and NFT positron emission tomography (PET) and magnetic resonance imaging (MRI) scans, cognitive testing, and gait assessments at baseline and 32 months. Residual change regression models were conducted. RESULTS: Higher baseline …

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Royal Canadian Mounted Police Cadets’ Exposure To Potentially Psychologically Traumatic Events During The Cadet Training Program, Katie L. Andrews, Kirby Q. Maguire, Laleh Jamshidi, Tracie O. Afifi, Jolan Nisbet, Robyn E. Shields, Taylor A. Teckchandani, Gordon J.G. Asmundson, Alain Brunet, Lisa M. Lix, Shannon Sauer-Zavala, Jitender Sareen, Terence M. Keane, J. Patrick Neary, R. Nicholas Carleton Apr 2025

Royal Canadian Mounted Police Cadets’ Exposure To Potentially Psychologically Traumatic Events During The Cadet Training Program, Katie L. Andrews, Kirby Q. Maguire, Laleh Jamshidi, Tracie O. Afifi, Jolan Nisbet, Robyn E. Shields, Taylor A. Teckchandani, Gordon J.G. Asmundson, Alain Brunet, Lisa M. Lix, Shannon Sauer-Zavala, Jitender Sareen, Terence M. Keane, J. Patrick Neary, R. Nicholas Carleton

Psychology Faculty Publications

Lifetime exposures to potentially psychologically traumatic events (PPTEs) among Royal Canadian Mounted Police (RCMP) cadets starting the Cadet Training Program (CTP) appear lower than exposures reported by serving RCMP, but the prevalence of PPTE exposures during the CTP remains unknown. The current study assessed PPTE exposures during the CTP and examined associations with mental disorders among RCMP cadets. Participants were cadets (n = 449, 24.7% women) from the larger RCMP Longitudinal Study who self-reported critical incidents, PPTE exposures, and mental health disorder symptoms at pretraining and predeployment. Most participants reported no exposures to a PPTE (n = 374, 83.3%) during …

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Assessing Coronavirus Disease 2019 Pandemic Impacts On The Health Of People Who Inject Drugs Using A Novel Data Sharing Model, Heather Bradley, Nicole Luisi, Anastasia Carter, Terri D. Pigott, Daniela Abramovitz, Sean T. Allen, Alice Asher, Chelsea Austin, Tyler S. Bartholomew, Marianna Baum, Amy Board, Basmattee Boodram, Annick Borquez, Kathryn A. Brookmeyer, Kate Buchacz, Janet Burnett, Hannah L.F. Cooper, Nicole Crepaz, Kora Debeck, Judith Feinberg, Chunki Fong, Edward Freeman, Nathan Woo Furukawa, Becky Genberg, Pamina Gorbach, Holly Hagan, Kanna Hayashi, Emalie Huriaux Mar 2025

Assessing Coronavirus Disease 2019 Pandemic Impacts On The Health Of People Who Inject Drugs Using A Novel Data Sharing Model, Heather Bradley, Nicole Luisi, Anastasia Carter, Terri D. Pigott, Daniela Abramovitz, Sean T. Allen, Alice Asher, Chelsea Austin, Tyler S. Bartholomew, Marianna Baum, Amy Board, Basmattee Boodram, Annick Borquez, Kathryn A. Brookmeyer, Kate Buchacz, Janet Burnett, Hannah L.F. Cooper, Nicole Crepaz, Kora Debeck, Judith Feinberg, Chunki Fong, Edward Freeman, Nathan Woo Furukawa, Becky Genberg, Pamina Gorbach, Holly Hagan, Kanna Hayashi, Emalie Huriaux

Epidemiology and Environmental Health Faculty Publications

Objective: Using an innovative data sharing model, we assessed the impacts of the COVID-19 pandemic on the health of people who inject drugs (PWID). Design: The PWID Data Collaborative was established in 2021 to promote data sharing across PWID studies in North America. Contributing studies submitted aggregate data on 23 standardized indicators during four time periods: prepandemic (March 2019 to February 2020), early-pandemic (March 2020 to February 2021), mid-pandemic (March 2021 to February 2022), and late pandemic (March 2022 to February 2023). Methods: We present study-specific and meta-analyzed estimates for the percentage of PWID who took medications for opioid use …

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A Satellite Cell-Dependent Epigenetic Fingerprint In Skeletal Muscle Identity Genes After Lifelong Physical Activity, Kevin A. Murach, Davis A. Englund, Toby L. Chambers, Cory M. Dungan, Hunter L. Porter, Jonathan D. Wren, Willard M. Freeman, Esther E. Dupont-Versteegden, Yuan Wen Mar 2025

A Satellite Cell-Dependent Epigenetic Fingerprint In Skeletal Muscle Identity Genes After Lifelong Physical Activity, Kevin A. Murach, Davis A. Englund, Toby L. Chambers, Cory M. Dungan, Hunter L. Porter, Jonathan D. Wren, Willard M. Freeman, Esther E. Dupont-Versteegden, Yuan Wen

Physiology Faculty Publications

Satellite cells comprise a small proportion of mononuclear cells in adult skeletal muscle. Despite their relative rarity, satellite cells have critical functions in muscle adaptation, particularly during prolonged exercise training. The mechanisms by which satellite cells mediate skeletal muscle responsiveness to physical activity throughout the lifespan are still being defined, but epigenetic regulation may play a role. To explore this possibility, we analyzed global DNA methylation patterns in muscle tissue from female mice that engaged in lifelong voluntary unweighted wheel running with or without satellite cells. Satellite cells were ablated in adulthood using the tamoxifen-inducible Pax7-DTA model. Compared to sedentary …

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Could Psilocin Rescue Chronic, Stress-Accelerated, Transcriptional Aging In Brain?, Danny R. Craig, Eric M. Blalock Mar 2025

Could Psilocin Rescue Chronic, Stress-Accelerated, Transcriptional Aging In Brain?, Danny R. Craig, Eric M. Blalock

Journal of Pharmacology & Nutritional Sciences

Brain aging (BA) processes are complex, often affect multiple systems, and frequently lead to cognitive decline and increased susceptibility to insults. BA appears to be a primary risk for the development of many prominent neurodegenerative pathologies. The US Census Bureau predicts that the aging population (65+) will represent a greater proportion of the US population than children (under 18) by 2034, dramatically increasing the burden on health-care infrastructure.17 Several mechanisms of stress driven, aging-related neurologic dysfunction have been advanced in the past 50 years and include: Stress hormone exposure and glucocorticoid cascade;7, 16 calcium ion dyshomeostasis;8 allostatic …

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Abuse-Deterrent Formulations And Opioid-Related Harms In North Carolina, 2010-2018, Bethany L. Diprete, Nabarun Dasgupta, G. Yeon Oh, Daniela C. Moga, Svetla Slavova, Emily Slade, Chris Delcher, Brian W. Pence, Shabbar I. Ranapurwala Mar 2025

Abuse-Deterrent Formulations And Opioid-Related Harms In North Carolina, 2010-2018, Bethany L. Diprete, Nabarun Dasgupta, G. Yeon Oh, Daniela C. Moga, Svetla Slavova, Emily Slade, Chris Delcher, Brian W. Pence, Shabbar I. Ranapurwala

Epidemiology and Environmental Health Faculty Publications

Abuse-deterrent formulations of opioid analgesics (ADFs) were introduced to reduce opioid-related harms among pain patients, but postmarketing study results have been mixed. However, these studies may be subject to bias from selection criteria, comparator choice, and potential confounding by “indication,” highlighting the need for thorough study design considerations. In a sample of privately insured patients prescribed ADF or non-ADF extended-release/long-acting (ER/LA) opioids in North Carolina, we implemented a version of the prevalent new-user design to evaluate the relationship between ADFs and opioid use disorder (OUD, n = 235) and opioid overdose (n = 18) through 6 months of follow-up using …

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Among-Population Variation In Telomere Regulatory Proteins And Their Potential Role As Hidden Drivers Of Intraspecific Variation In Life History, Sarah E. Wolf, Mary J. Woodruff, David A. Chang Van Oordt, Ethan D. Clotfelter, Daniel A. Cristol, Elizabeth P. Derryberry, Stephen M. Ferguson, Mark T. Stanback, Conor C. Taff, Maren N. Vitousek, David F. Westneat, Kimberly A. Rosvall Mar 2025

Among-Population Variation In Telomere Regulatory Proteins And Their Potential Role As Hidden Drivers Of Intraspecific Variation In Life History, Sarah E. Wolf, Mary J. Woodruff, David A. Chang Van Oordt, Ethan D. Clotfelter, Daniel A. Cristol, Elizabeth P. Derryberry, Stephen M. Ferguson, Mark T. Stanback, Conor C. Taff, Maren N. Vitousek, David F. Westneat, Kimberly A. Rosvall

Biology Faculty Publications

Biologists aim to explain patterns of growth, reproduction and ageing that characterize life histories, yet we are just beginning to understand the proximate mechanisms that generate this diversity. Existing research in this area has focused on telomeres but has generally overlooked the telomere's most direct mediator, the shelterin protein complex. Shelterin proteins physically interact with the telomere to shape its shortening and repair. They also regulate metabolism and immune function, suggesting a potential role in life history variation in the wild. However, research on shelterin proteins is uncommon outside of biomolecular work. Intraspecific analyses can play an important role in …

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Macroevolutionary Inference Of Complex Modes Of Chromosomal Speciation In A Cosmopolitan Plant Lineage, Carrie M. Tribble, José Ignacio Márquez-Corro, Michael R. May, Andrew L. Hipp, Marcial Escudero, Rosana Zenil-Ferguson Mar 2025

Macroevolutionary Inference Of Complex Modes Of Chromosomal Speciation In A Cosmopolitan Plant Lineage, Carrie M. Tribble, José Ignacio Márquez-Corro, Michael R. May, Andrew L. Hipp, Marcial Escudero, Rosana Zenil-Ferguson

Biology Faculty Publications

The effects of single chromosome number change—dysploidy – mediating diversification remain poorly understood. Dysploidy modifies recombination rates, linkage, or reproductive isolation, especially for one-fifth of all eukaryote lineages with holocentric chromosomes. Dysploidy effects on diversification have not been estimated because modeling chromosome numbers linked to diversification with heterogeneity along phylogenies is quantitatively challenging. We propose a new state-dependent diversification model of chromosome evolution that links diversification rates to dysploidy rates considering heterogeneity and differentiates between anagenetic and cladogenetic changes. We apply this model to Carex (Cyperaceae), a cosmopolitan flowering plant clade with holocentric chromosomes. We recover two distinct modes of …

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