Digital Commons Network^™

The International Soft Tissue Sarcoma Consortium, Gianni Bisogno, Monika Sparber-Sauer, David Rodeberg, Johannes H.M. Merks, Ewa Koscielniak, Suzanne L. Wolden, Gian Luca De Salvo, Paola Del Bianco, Wei Xue, Martin Ebinger, Christian Vokuhl, Rajkumar Venkatramani, Samuel L. Volchenboum, Brian Furner, Veronique Minard Colin, Douglas S. Hawkins

Surgery Faculty Publications

Background: The International Soft Tissue Sarcoma Consortium (INSTRuCT) was established in 2017 to enhance international collaboration. This study describes the characteristics of rhabdomyosarcoma (RMS) patients in the INSTRuCT database and examines differences across contributing groups. Methods: INSTRuCT includes data Children’s Oncology Group (COG), Cooperative Weichteilsarkom Studiengruppe (CWS), and European Paediatric Soft Tissue Sarcoma Study Group (EpSSG) along with prior studies from Malignant Mesenchymal Tumour Committee (MMT) and Italian Soft Tissue Sarcoma Committee (STSC). Data standardization was supported by the University of Chicago’s Pediatric Cancer Data Commons. Pseudonymized patient-level data from clinical trials were harmonized. Differences across groups were assessed using …

The Kentucky Microbiome Dataset, Rachel L. Washburn, Douglas C. Curl

Research Data--KGS

The Kentucky Microbiome Dataset is a continuously updated geolocated dataset which describes the distribution and diversity of microorganisms across the Commonwealth of Kentucky. Each geolocated point represents a location reported in the peer-reviewed literature where microorganisms were sampled from soil, water, geologic substrates, or clinical settings. Environmental studies include only non-host-associated, non-clinical microorganisms sampled from natural environments. Clinical studies are mapped separately to highlight locations where investigations into host-associated or human health-related microbes have occurred.

For each location, associated metadata include study information, taxonomic classifications, sample type, sampling method, latitude and longitude, sampling date, publication reference, and a direct link …

The Timing And Significance Of Mid-Crustal Shearing And Exhumation Of Amphibolite-Facies Rocks Along The Great Glen Fault Zone, Scotland, Richard D. Law, J. Ryan Thigpen, Calvin A. Mako, Andrew Kylander-Clark, Mark J. Caddick, Lowell R. Moore, Cassandra Becker, Robert E. Holdsworth, Robin A. Strachan, A. Graham Leslie

Earth and Environmental Sciences Faculty Publications

The Rosemarkie Inlier lies on the NW side of the Great Glen Fault Zone (GGFZ) and is composed of foliated and lineated Archean orthogneisses and Moine metasedimentary rocks. The mylonitic foliation strikes NE–SW (parallel to the GGFZ), dips steeply SE and contains a gently to moderately plunging mineral lineation. Microstructural and quartz c-axis fabric analyses indicate that oblique sinistral shearing occurred under amphibolite-facies conditions. Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) analyses on monazite rims in the gneisses yielded ²⁰⁶Pb/²³⁸U ages of 401.8 ± 4.8 Ma (including 2 (Formula presented.) uncertainty and a propagated additional 1% …

Associations Of Hepatitis C Virus (Hcv) Antibody Positivity With Opioid, Stimulant, And Polysubstance Injection Among People Who Inject Drugs (Pwid) In Rural U.S. Communities, Angela T. Estadt, William C. Miller, David Kline, Bridget M. Whitney, April M. Young, P. Todd Korthuis, Thomas J. Stopka, Judith Feinberg, William A. Zule, Mai T. Pho, Peter D. Friedmann, Ryan P. Westergaard, Kellene V. Eagen, Andrew Seaman, Jimmy Ma, Vivian F. Go, Kathryn E. Lancaster

Epidemiology and Environmental Health Faculty Publications

Background: People who inject drugs (PWID) in the rural U.S. often inject stimulants, alone or with opioids. The impact of these substance use patterns may influence HCV risk behaviors. This analysis examines the associations of HCV antibody positivity with injecting only opioids, only stimulants (methamphetamine/cocaine), and opioids and stimulants together among rural PWID. Methods: The Rural Opioid Initiative (ROI) consists of eight research sites that enrolled people who use drugs in rural communities in ten U.S. states from 2018 to 2020. This cross-sectional analysis included adult participants who resided in a study area and injected any drug in the past …

The Effects Of Parental Occupational Exposures On Autism Spectrum Disorder Severity And Skills In Cognitive And Adaptive Domains In Children With Autism Spectrum Disorder, Erin C. Mccanlies, Ja Kook Gu, Claudia C. Ma, Wayne T. Sanderson, Yunin J. Ludeña-Rodriguez, Irva Hertz-Picciotto

Epidemiology and Environmental Health Faculty Publications

No abstract provided.

Who Reconstitutes The Chemotherapy? The Educational And Practice Needs Of Oncology Pharmacists In West Africa: A Call For Multidisciplinary Team Approach In Oncology Care., Runcie C.W. Chidebe, Ramatu M. Alabelewe, Krishna Prasad Sapkota, Darlingtina K. Esiaka, Candidus C. Nwakasi, Gloria C. Okwu, Jacinta Emejulu, Adamu A. Umar, Ndifreke Okwuegbunam, Funsho David, Toyosi Adepoju, Agha A. Agha, Ejike S. Ugwu, Simeon C. Aruah, Richard Mshelia, Rob Duncombe, Noel N. Wannang, Peace C. Babalola, R. Donald Harvey, Cindy O'Bryant, Folakemi T. Odedina

Behavioral Science Faculty Publications

PURPOSE: Oncology pharmacists (OPs) play a crucial role in cancer care, treatment, survivorship, and multidisciplinary teams (MDTs). OPs have specialized training in designing, administering, monitoring, and modifying oncology chemotherapy; managing adverse events; and evaluating clinical trials and investigational drugs. Yet, the state of OP has remained largely unknown in the clinical oncology workforce of the West African region. Therefore, this study aimed to understand who reconstitutes chemotherapy and to explain the OP educational and practice needs, challenges, and solutions in Nigeria.

MATERIALS AND METHODS: Using a concurrent embedded mixed method design, 35 OPs completed a questionnaire, and 12 others responded …

Genetically Proxied Blood Pressure, Vascular Brain Injury, And Alzheimer's Disease Pathology, Iyas Daghlas, Michelle R. Caunca, Lincoln M.P. Shade, Malik Nassan, Kristine Yaffe, David W. Fardo, Dipender Gill

Biostatistics Faculty Publications

INTRODUCTION: Lower blood pressure (BP) is linked to reduced dementia risk, though it is uncertain whether this benefit stems solely from mitigating vascular brain injury (VBI) or also extends to directly influencing Alzheimer's disease (AD) pathology. We leveraged Mendelian randomization (MR) to assess whether lifelong lower BP is causally associated with neuropathological correlates of VBI and AD. METHODS: We identified genetic proxies for systolic and diastolic BP (n = 1,028,980) and applied them in MR analyses of post mortem neuropathological measures of VBI and AD (n = 6363–7786). RESULTS: Genetically proxied lower systolic BP associated with reduced risk of all …

Endothelium- And Fibroblast-Derived C-Type Natriuretic Peptide Prevents The Development And Progression Of Aortic Aneurysm, Aisah A. Aubdool, Amie J. Moyes, Cristina Perez-Ternero, Reshma S. Baliga, Jaspinder Singh Sanghera, M. Taaha Syed, Kareemah Jaigirdar, Anmolpreet K. Panesar, Janice C. Tsui, Yanming Li, Hernan G. Vasquez, Ying H. Shen, Scott A. Lemaire, Juliette Raffort, Ziad Mallat, Hong S. Lu, Alan Daugherty, Adrian J. Hobbs

Physiology Faculty Publications

BACKGROUND: Thoracic (TAA) and abdominal (AAA) aortic aneurysm are life-threatening diseases characterized by dilation, inflammation, and structural weakness; development of pharmacological therapies is desperately needed. CNP (C-type natriuretic peptide) plays a key role in vascular homeostasis, mediating vasodilator, anti-inflammatory, and antiatherogenic actions. Since such processes drive AA, we determined the role of endogenous CNP in offsetting pathogenesis. METHODS: Tissue from patients with AA was analyzed to determine the consequences on CNP signaling. Ascending and suprarenal aortic diameters were assessed at baseline and following Ang II (angiotensin II; 1.44 mg/kg per day) infusion in wild-type, endothelium-restricted (ecCNP^-/-), fibroblast-restricted (fbCNP …

Age And Sex Are Associated With Alzheimer's Disease Neuropathology In Down Syndrome, Elizabeth J. Andrews, Phong T. Ngo, Jesse R. Pascual, Freddy Gonzalez, Michael Phelan, Sierra T. Wright, Jordan Harp, Frederick Schmitt, Florence Lai, Patrick J. Lao, Adam M. Brickman, Julia Kofler, Milos D. Ikonomovic, Elizabeth Head

Psychology Faculty Publications

INTRODUCTION: This study investigates the association of age and biological sex with Alzheimer's disease (AD) neuropathology in Down syndrome (DS). METHODS: We examined the frontal/occipital cortex in people with DS (n = 14/13, 1–39 years), DS with AD (DSAD) neuropathology (n = 18/19, 42–61 years), late-onset AD (n = 15/16, 72–96 years), and age-matched controls (n = 50/47)(n = 156). The area occupied by AT8 and 6E10 immunolabeling, representing tangle and plaque loads, respectively, was used for segmented linear regression analyses. RESULTS: There was elevated neuropathology after age 35 in DSAD, with inflection points at ∼31 years (amyloid-β [Aβ]) and …

On-Farm Investigative Development: Bridging The Gap Between Pasture Plant Breeder, Agronomist, Consultant And Farmer, J M. Keoghan, W J. Fraser

IGC Proceedings (1977-2023)

Most pasture cultivars used for pastoral development in New Zealand's South Island hill and high Country are conventional species, bred primarily for intensive lowland farming systems. Recently, however, as the limitations of relying on broadly adaptable "national" cultivars over a very wide range of environments and farming systems have been realised, more breeding and selection programmes have focused on the identi­fication and development of plants for specific regions, environments and farming systems (Corkill et al., 1981). Because of the extreme environmental diversity, new pasture species and cultivars should have a greater role in grazing systems in the South Island hill …

The Rhetoric Of Responsibilization: A Rhetorical Analysis Of Pre-Exposure Prophylaxis Campaigns For Hiv Prevention, Catherine M. Pabalate

Kentucky Undergraduate Journal for the Health Humanities

Responsibilization refers to the process by which patients are made accountable for their health and wellbeing, which is determined by their habits and behaviors. Though responsibilization affords greater agency to patients, it can also result in anxiety and guilt when the patient appears "deviant" or "noncompliant." Because sexual behavior is attributed to the causality of HIV/AIDS, patients’ sexual patterns and choices are included within their medical decision-making. This rhetorical analysis focuses on pharmaceutical campaigns and commercials for pre-exposure prophylaxis (PrEP), which were released between 2012 and 2024 and are targeted towards patients at-risk for HIV/AIDS. Findings suggest that specific rhetorical …

Association Of Fentanyl Test Strip Results And Change In Drug Use Behaviors, Kitty H Gelberg, Nabila El-Bassel, Denise C Babineau, Rachel A Vickers-Smith, Laura C Fanucchi, Janet E Childerhose, Megan E Hall, Megan E Dzurec, Jennifer Villani, Mary R Russo, Patricia Lebaron, Katherine R Marks, Kathyrn E Lancaster, Louisa Gilbert, James L David, Barry S Eggleston, Carter A Roeber, Emmanuel A Oga, Redonna K Chandler, Sharon L Walsh

Epidemiology and Environmental Health Faculty Publications

BACKGROUND: The Stay Safe Study, conducted between May and December 2023 in the United States, investigated the association between fentanyl test strip (FTS) use and risk reduction behaviors. This paper examines the association between self-reported FTS results and change in drug use behaviors.

METHODS: We solicited self-reported drug and FTS use among people who use drugs (PWUD), with a baseline and four weekly surveys over a 28-day observation period in three states (Kentucky, New York and Ohio). For each day participants reported drug use, they were asked types of drugs used, use of FTS, FTS results, and 12 drug use …

How To Gender Include, Stephen Krueger

Library Faculty and Staff Publications

Gender inclusion is not an optional part of library work—at least, it isn’t if we want all those “Libraries Are For Everyone” signs to be true. And yet, the reality is that many libraries fail the most basic aspects of gender inclusion for patrons, employees, or both. Even in libraries where Trans 101 trainings do occur and are well received, or where the baseline of knowledge among employees is relatively high, the question remains: What now?

This article intends to answer that question. Very broadly speaking, gender inclusion work in libraries means sustained action to ensure that some patrons and …

Variation In The Potentially Inappropriate Use Of Antipsychotic And Benzodiazepine Medications Among Individuals Receiving Residential Medication Management Reviews, Mouna J. Sawan, Alexander J. Clough, Jodie Hillen, Andrew R. Zullo, Daniela C. Moga, Natalie Soulsby, Danijela Gnjidic

Epidemiology and Environmental Health Faculty Publications

Objectives To describe the variation in the use of potentially inappropriate antipsychotic and benzodiazepine medications in residents who have received a medication review and to evaluate the extent to which this variation is associated with aged care home (ACH) and resident characteristics. Methods This cross-sectional, retrospective study used pharmacist-extracted data from 15,442 residents across 342 Australian ACHs who had a medication review during 2019. The proportion of residents receiving ≥1 potentially inappropriate antipsychotic and benzodiazepine medication according to Beers criteria were classified into quintiles by facility usage (Q1-Q5). Quintile characteristics were compared using descriptive analysis of facility and resident data. …

Wetland Treatment Systems For Municipal Wastewater At A Bourbon Distillery And Potential Value Of Incorporating Stillage For Water Treatment Enhancement, Katherine Ristola, Tiffany Messer, Czarena Crofcheck, Tyler Barzee, Wayne Sanderson

Epidemiology and Environmental Health Faculty Publications

The use of constructed treatment wetlands as a secondary treatment method for wastewater effluent from package treatment plants and distillery stillage has the potential to be an innovative, sustainable method for improving water quality. However, the use of constructed wetlands to treat bourbon whole stillage and a distillery bottling facility’s wastewater treatment plant effluent has been limited. Therefore, the objectives of this study were to (1) quantify constructed wetland water quality improvement as a secondary treatment method for a distillery’s municipal wastewater, (2) optimize treatment design to meet wastewater effluent discharge limits, and (3) quantify the potential to enhance constructed …

Thriving In The Tropics, Hansika K. Herath, D. Nicholas Mcletchie

Biology Faculty Publications

Increasing frequency and intensity of global warming pose a profound threat to plant species persistence. Most investigations on plants' resilience to heat events focus on few genotypes of model species. Novel insights into resilience mechanisms will be gained by focusing on natural variation in thermotolerance and its relationship to local-abiotic factors. Additionally, studying species that survived 'ancient periods' of high temperatures provides insight into resilience mechanisms. Within a species, we assessed spatial thermotolerance variation, its association with temperature and light, while testing for thermotolerance sex differences and its relationship with population sex ratios. We used Marchantia inflexa, a species with …

Cluster-Based Volt/Var Optimization On A Utility Distribution Feeder With Forecasted Ev Penetration, Steven B. Poore, Grant M. Fischer, Rosemary E. Alden, Evan S. Jones, Aron Patrick, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

With significant increase in EV adoption expected in the near future and the associated impacts on power systems, the effect of volt/var optimization (VVO) as the next step to conservation voltage reduction (CVR), requires reevaluation. Implementation of a cluster-based VVO control strategy employs a novel approach with machine learning (ML) load forecasting to reduce device adjustments through k-means clustering of contiguous time steps with similar active power load in which a single adjustment would be sufficient. The cluster-based VVO method is tested on a complex real world utility distribution feeder with 2,018 nodes, 8.65MW peak load, 9 capacitor banks (CBs), …

Hybrid Fea And Meta-Modeling For De Optimization Of A Pm Stator-Excited Motor With A Reluctance Rotor, Oluwaseun A. Badewa, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

This paper presents an innovative method for designing high-performance electric motors by integrating machine learning (ML) based meta-modeling with a differential evolution (DE) optimization algorithm. The approach utilizes finite element analysis (FEA) data to train the ML meta-model, allowing for efficient optimization of high-power-density machines, such as the reluctance rotor and permanent magnet (PM) stator combined excitation motor, which is characterized by nonlinearities. The meta-modeling process employs an Artificial Neural Network (ANN) with 3 hidden layers and uses the motor’s geometrical variables as inputs. The accuracy of the meta-model in capturing the nonlinear relationships between design parameters, core losses, and …

Three And Two Phase Rotating Field Inductive Couplers For Wireless Power Transfer With One Phase Per Layer Windings, Donovin D. Lewis, Lucas Gastineau, Omer Onar, Dan M. Ionel

Electrical and Computer Engineering Graduate Research

Multiphase inductive wireless charging coils have been proposed recently to improve coupler surface power density, reduce component stress and size, and provide near-constant power delivery to charge mobile electric systems. Several aspects for the fundamental characterization of multiphase coils are explored up to six phases including approximate mutual inductance with size and turn variation, induced voltage, and output power estimation. The relative component stress and size of passive components for resonant operation are compared between the multiphase variants. A combination of an experimentally validated 3D electromagnetic finite element analysis (FEA) and power electronic co-simulations are used to validate the estimated …

The Positive Association Of Physical Activity On Sadness And Suicide Behaviors For Youth Who Have Been Bullied, Katelon Kerns, Kahir Jawad, Yana Feygin, V. Faye Jones, W. David Lohr, Jennifer Le, Kiana Fields, Jennifer Porter, Sarah Ouellette, Theresa Kluthe, Deborah Winders Davis

Biostatistics Faculty Publications

Background: Youth mental health is a public health crisis. Bullying has been associated with adverse mental health outcomes including depression and suicidal ideation. We aimed to update information regarding the associations between bullying and sadness and three suicide-related outcomes, along with the potential moderating effect of physical activity (PA). Methods: Using the 2017–2021 Youth Risk Behavior Surveillance System (YRBSS) with students in grades 9–12 we used descriptive statistics, chi-square tests, and multivariable logistic regressions to examine the association between students who have been bullied and who reported feeling sad or hopeless, as well as considered, planned, and/or attempted suicide, within …

Screening For Mental Health Symptoms Following Pediatric Traumatic Injury, Julia Price, Meghan L. Marsac, Leigh E. Ridings, Caitlin H. Axtmayer, Richard James, Melanie Stroud, Maria Bautista Durand, Shannon W. Longshore, Jennifer J. Freeman, Todd Nickoles, Ian Mitchell, Chia Lun Yang, Nancy Kassam-Adams

Psychology Faculty Publications

No abstract provided.

Development And Evaluation Of A Simple Human Body Link Model Considering The Degrees-Of-Freedom Of Shoulders, Mizuki Takeda, Yuki Saito, Kaiji Sato

Progress in Scale Modeling, an International Journal

Modeling of the human body is widely utilized in the field of human–robot interaction, warranting the development of a simple model to measure and recognize the human body movements. To this end, a two-dimensional (2D) human body link model in the sagittal plane has been used to represent the human body with rotating joints and links connecting these joints. The joint positions can be determined by using the coordinates of a limited number of points on the links and estimated using a few sensor outputs when the links are of constant length. However, models with constant link lengths may result …

Enhancing Communication For Individuals With Complex Communication Needs: The Critical Role Of Training And Evidence-Based Aac Strategies, Rachel H. Williams

Early Childhood, Special Education, and Counselor Education Faculty Publications

Communication is a basic human right, as affirmed by the National Joint Committee for the Communication Needs of Persons with Severe Disabilities (NJC, 2024). For individuals with complex communication needs (CCN), special considerations must be taken into account to ensure equitable access to this right and must be supported through appropriate services, tools, and strategies. Augmentative and alternative communication (AAC) systems are essential for many individuals with CCN, enabling access to expressive and receptive language. However, successful AAC implementation requires well-trained educators, speech-language pathologists, and support staff who understand how to assess, model, and support communication effectively (Brady et al., …

Determinants Of Willingness To Share Wearable Health Data With Health Care Providers In Appalachian Populations: An Exploratory Study, Gilbert Munoz Cornejo, Joonghee Lee

Journal of Appalachian Health

Background: Wearable health devices capture metrics (e.g., physical activity, ECG, sleep) that can enhance care when shared with providers. Yet, willingness to share wearable data may differ in Appalachia, where chronic disease burdens, mistrust, and limited infrastructure pose unique challenges.

Objective: This study explored (1) which sociodemographic, health, and digital behaviors correlate with willingness to share wearable data and (2) how these insights can guide region-specific interventions in Appalachia.

Methods: We analyzed 320 Appalachian respondents from the Health Information National Trends Survey (HINTS 6). Descriptive statistics and logistic regression models examined willingness to share wearable data. Because of small cell …

Heartache In The Heartland: Unraveling The Social Roots Of Deaths Of Despair In Kentucky, Lyndsey K. Blair, Madeline M. Tomlinson, Michele Abee-Biskis, Jessica Hume, Gabri Warren

Journal of Appalachian Health

Introduction: Deaths of despair (DoD), encompassing suicides, drug overdoses, and alcohol-related liver diseases, have emerged as a critical public health crisis in the United States, with their rise particularly pronounced from 1995 to 2013 and exacerbated by the COVID-19 pandemic. Kentucky, grappling with high rates of substance use disorder, poor mental health, and economic hardship, is at the forefront of this issue, particularly in its rural and Appalachian regions.

Purpose: This study explores the social determinants contributing to DoD in Kentucky, focusing on economic and social factors that influence rising rates of suicide, drug overdose, and alcohol-related liver disease. The …

Time And Location: Physical Activity Trends In Parents And Children In A Rural Region During Covid-19, Brooke C. Towner, Robert Broce, Rebecca A. Battista

Journal of Appalachian Health

Introduction: COVID-19 restrictions altered the structure of the school and workday for families with children and led to changes in active transportation. Continued restrictions impacted access to many community locations and led to changes in physical activity (PA) behavior.

Purpose: The objectives of the study were to describe the changes in the 1) amount of PA time per day, 2) frequency of PA, and 3) sitting time. Information about how PA changed for parents and children during the COVID-19 pandemic will have potential implications for education, public health, and recreation management.

Methods: This cross-sectional study enlisted participants via an online …

Children Living With Type 1 Diabetes In The Public School System, Madison M. Wilson

Kentucky Undergraduate Journal for the Health Humanities

Type 1 Diabetes is a worldwide chronic condition that typically develops during adolescence and requires life-long treatment and management. Management of this disease is extremely complicated for a child to manage on their own and requires a community of individuals to help them. With children spending most of their days at school, the school’s teachers and staff are vital to the care and management of their condition while attending public school. Children with Type 1 Diabetes in public school systems face many disparities and a reform is needed. Looking at this population through a holistic health science lens can help …

A Review Of Disassembly Systems For Circular Product Design, Giovanni Formentini, Joao Pj. Prioli, Junwon Ko, Buddhika M. Hapuwatte, Vincenzo Ferrero, Fazleena Badurdeen, Jeremy L. Rickli, Devarajan Ramanujan

Mechanical Engineering Faculty Publications

Circular Economy (CE) is described as a means for maintaining products and materials in circulation while regenerating nature. This shift requires considering aspects at the product design phase that were not previously prioritized. One such aspect, disassembly, is a key enabler for CE. Design for Disassembly methodologies have been deployed for several years to enhance disassembly performance. However, when CE is of interest, it is essential to consider how disassembly affects the entire product life cycle system. In this regard, this paper proposes a literature review of relevant DfD methods from a system engineering perspective to evaluate their effects on …

Rural Access To Certified Community Behavioral Health Clinics (Ccbhcs), Aaron P. Smith, Jeffrey Talbert

Rural & Underserved Health Research Center Publications

Overview of Key Findings

▪ The number of Certified Community Behavioral Health Clinics (CCBHCs) expanded from 2022 to 2023, increasing from 371 to 480. Most of the growth was driven by rural counties (57.9% increase, 126 to 199) while urban counties increased by 14.7% (245 to 281).

▪ The number of services offered at CCBHCs is similar in both rural and urban localities, but urban CCBHCs were more likely to offer services that cater to a diverse client base, such as speaking different languages, and nicotine cessation programs. Rural CCBHCs were more likely to have programs for minors, veterans, and …

Fentanyl Test Strip Use And Overdose Risk Reduction Behaviors Among People Who Use Drugs, Rachel A Vickers-Smith, Kitty H Gelberg, Janet E Childerhose, Denise C Babineau, Redonna Chandler, James L David, Lauren D'Costa, Megan Dzurec, Barry Eggleston, Amanda Fallin-Bennett, Laura C Fanucchi, Soledad Fernandez, Jace Gilbert, Louisa Gilbert, Megan E Hall, Brooke E Hiltz, Michael W Konstan, Kathryn E Lancaster, Beth Linas, Katherine R Marks, Nichole Michaels, Jennifer Miles, Fernando Montero, Haley J Ramsey Harden, Carter Roeber, Mary R Russo, Rachel Taylor, Melissa A Theis

Epidemiology and Environmental Health Faculty Publications

IMPORTANCE: Illegal fentanyl is driving overdose mortality, and fentanyl test strips (FTS) can be used to test drugs for fentanyl at the point of consumption. Evidence on whether FTS use is associated with overdose risk reduction behaviors is encouraging, but largely limited to smaller, single-site studies.

OBJECTIVE: To determine whether self-reported baseline FTS use among people who use drugs (PWUD) was associated with overdose risk reduction behaviors and nonfatal overdose over a 28-day follow-up.

DESIGN, SETTING, AND PARTICIPANTS: Multisite, observational cohort study of PWUD conducted from May to December 2023 as an ancillary study of the HEALing Communities Study, which …