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Gimyb76, A Meja-Inducible R2r3-Type Transcription Factor, Regulates Licochalcone A Biosynthesis In Licorice (Glycyrrhiza Inflata), Yuping Li, Zhigeng Wu, Jixiang Zhu, Jiangyi Zeng, Yongliang Liu, Jihua Wang, Ling Yuan, Ying Wang, Yongqing Li Feb 2026

Gimyb76, A Meja-Inducible R2r3-Type Transcription Factor, Regulates Licochalcone A Biosynthesis In Licorice (Glycyrrhiza Inflata), Yuping Li, Zhigeng Wu, Jixiang Zhu, Jiangyi Zeng, Yongliang Liu, Jihua Wang, Ling Yuan, Ying Wang, Yongqing Li

Plant and Soil Sciences Faculty Publications

Licochalcone A (LCA) is a characteristic compound in licorice Glycyrrhiza inflata and is widely utilized in pharmaceutical and cosmetic industries. However, the biosynthetic pathway and regulatory mechanisms of LCA remain poorly understood. In this study, we first found the accumulation of LCA is induced by methyl jasmonate (MeJA). Given that MYB transcriptional factors are well-documented as key regulators of flavonoid biosynthesis, we identified a total of 147 GiR2R3-MYB genes in G. inflata, which were classified into 28 subgroups. The chromosome distributions, sequence characteristics, gene structures, duplication events and cis-acting elements were also investigated. Through integrated analysis of GiR2R3-MYBs expression patterns …


Post-Translational Control Of Biotic Stress-Related Nicotine Biosynthesis By A Map Kinase Signaling Cascade, Yan Zhou, Yongliang Liu, Ruiqing Lyu, Sanjay Kumar Singh, Xueyi Sui, Xin Hou, Sitakanta Pattanaik, Ling Yuan Feb 2026

Post-Translational Control Of Biotic Stress-Related Nicotine Biosynthesis By A Map Kinase Signaling Cascade, Yan Zhou, Yongliang Liu, Ruiqing Lyu, Sanjay Kumar Singh, Xueyi Sui, Xin Hou, Sitakanta Pattanaik, Ling Yuan

Plant and Soil Sciences Faculty Publications

The evolutionarily conserved mitogen-activated protein kinase (MAPK) cascades relay extracellular signals into cells, triggering a variety of cellular responses. We previously revealed NtMPK4 as a positive regulator of nicotine biosynthesis; however, its upstream regulation remains unclear. Here, we characterized a MAPK cascade, comprising NtMEKK1b, NtMPKK2a, and NtMPK4, that promotes nicotine biosynthesis. This signaling module transduces external cues, including jasmonate and pathogen elicitors such as flg22, into post-translational modifications that enhance transcriptional activity and pathway gene expression. NtMPKK2a physically interacts with and phosphorylates NtMPK4 in vivo, confirming its role as an upstream kinase. RNAi-mediated silencing of NtMPKK2a significantly reduced the expression …


Successful Biliary Re-Cannulation And Neo-Anastomosis Creation In Complete Bile Duct Occlusion Or Disruption Using A Combination Of Interventional Radiology And Endoscopic Techniques, Joshua G. Fricker, Tarik Babar, Husameddin El Khudari, Ali Ahmed, Dalton Norwood, Sergio A. Sánchez-Luna, Eric Bready, Ramzi Mulki, Kondal Kyanam, Shajan Peter, Andrew Gunn Feb 2026

Successful Biliary Re-Cannulation And Neo-Anastomosis Creation In Complete Bile Duct Occlusion Or Disruption Using A Combination Of Interventional Radiology And Endoscopic Techniques, Joshua G. Fricker, Tarik Babar, Husameddin El Khudari, Ali Ahmed, Dalton Norwood, Sergio A. Sánchez-Luna, Eric Bready, Ramzi Mulki, Kondal Kyanam, Shajan Peter, Andrew Gunn

Radiology Faculty Publications

Aims: Biliary strictures are a known complication of hepatobiliary and pancreatic surgeries. This retrospective descriptive series highlights six consecutive patients with complete bile duct occlusion or disruption who required a multidisciplinary approach with a combination of interventional radiology (IR) and endoscopic techniques to either re-cannulate or create a neo-anastomosis in the biliary system. Methods and Results: The biliary system was either re-cannulated or a neo-anastomosis was created using a small gauge needle (N = 3), a rendezvous procedure (N = 1), a radiofrequency ablation wire (N = 1), and the back end of a wire (N = 1). There was …


The American College Of Radiology Diagnostic Fluoroscopy Dose Index Registry Pilot, Steve D. Mann, Donald L. Miller, Grant Fong, Allen R. Goode, Emily L. Marshall, Thomas Nishino, Pavlina Boxx, Liqiang Ren, Celalettin Topbas, Alan H. Schoenfeld, Vivek Singh, Jie Zhang Feb 2026

The American College Of Radiology Diagnostic Fluoroscopy Dose Index Registry Pilot, Steve D. Mann, Donald L. Miller, Grant Fong, Allen R. Goode, Emily L. Marshall, Thomas Nishino, Pavlina Boxx, Liqiang Ren, Celalettin Topbas, Alan H. Schoenfeld, Vivek Singh, Jie Zhang

Radiology Faculty Publications

Background: The ACR Diagnostic Fluoroscopy Dose Index Registry (DIR-Fluoro) is expanding to include diagnostic fluoroscopy. Variations in dose reference points and overhead radiography events may introduce unique challenges for benchmarking. Purpose: To survey the technological status and dosimetric performance of fluoroscopes participating in the DIR-Fluoro pilot project, focusing on longitudinal stability and variability of fluoroscopic dose reporting accuracy across multiple institutions and vendors. Methods: Sixty-six fluoroscopic systems from nine institutions (24 facilities) were surveyed for facility type, fluoroscope type, image receptor type, age, dose reporting capabilities, and other key features. Of these, 56 were evaluable. Semi-annual measurements assessed reference air …


Low Temperature Green Synthesis Of Red Emitting Pb-Free Csmnbr3Perovskite Films, Saurabh Singh, Xiyu Wen, Fuqian Yang Jan 2026

Low Temperature Green Synthesis Of Red Emitting Pb-Free Csmnbr3Perovskite Films, Saurabh Singh, Xiyu Wen, Fuqian Yang

Chemical and Materials Engineering Faculty Publications

Lead halide perovskites (APbX3) have demonstrated exceptional opto-electronic properties, but their inherent toxicity and environmental hazards hindered their practical deployment in display technologies such as liquid crystal display (LCD) backlights. Herein, we report for the first time a facile, water-mediated synthesis of red-emitting CsMnBr3 thin films from an aqueous solution of CsBr and MnBr2 precursors at a low temperature of ∼50 °C. Unlike traditional synthesis routes reported for synthesis of CsMnBr3 powders or nanocrystals, relying heavily on toxic solvents, high temperatures, or inert atmospheres, the green approach utilizes water as a benign medium to facilitate …


Sustained Increase In Extracellular Atp In The Lung Induced By Chronic Inhalation Exposure To Nitrogen Dioxide, Nai Ju Chan, Yueh Yin Chen, Chun Chun Hsu, You Shuei Lin, Maxwell Zakeri, Mehdi Khosravi, Lu Yuan Lee Jan 2026

Sustained Increase In Extracellular Atp In The Lung Induced By Chronic Inhalation Exposure To Nitrogen Dioxide, Nai Ju Chan, Yueh Yin Chen, Chun Chun Hsu, You Shuei Lin, Maxwell Zakeri, Mehdi Khosravi, Lu Yuan Lee

Physiology Faculty Publications

Nitrogen dioxide (NO2) is an environmental air pollutant and a potent oxidant. Epidemiological studies have revealed a close association between chronic cough and long-term inhalation exposure to NO2. ATP can be released from airway/lung epithelial cells upon inhalation exposure to oxidants, and convincing evidence established in recent clinical studies indicated that extracellular ATP in the respiratory tract plays an important role in the pathogenesis of refractory chronic cough. However, whether inhalation exposure to NO2 elevates the ATP release in the lung is not yet known. Results of this study showed: 1) in awake rats, acute …


Agn Storm 2. Xi. Spectroscopic Reverberation Mapping Of The Hot Dust In Mrk 817, Hermine Landt, Benjamin D. Boizelle, Michael S. Brotherton, Laura Ferrarese, Travis Fischer, Varoujan Gorjian, Michael D. Joner, Daniel Kynoch, Jacob N. Mclane, Jake A.J. Mitchell, John W. Montano, Rogemar A. Riffel, David Sanmartim, Thaisa Storchi-Bergmann, Martin J. Ward, Aaron J. Barth, Edward M. Cackett, Gisella De Rosa, Rick Edelson, Jonathan Gelbord, Yasaman Homayouni, Keith Horne, Erin A. Kara, Gerard A. Kriss, Nahum Arav, Elena Dalla Bontà, Maryam Dehghanian, Gary J. Ferland, Carina Fian, Diego H. González Buitrago, Dragana Ilić, Shai Kaspi Jan 2026

Agn Storm 2. Xi. Spectroscopic Reverberation Mapping Of The Hot Dust In Mrk 817, Hermine Landt, Benjamin D. Boizelle, Michael S. Brotherton, Laura Ferrarese, Travis Fischer, Varoujan Gorjian, Michael D. Joner, Daniel Kynoch, Jacob N. Mclane, Jake A.J. Mitchell, John W. Montano, Rogemar A. Riffel, David Sanmartim, Thaisa Storchi-Bergmann, Martin J. Ward, Aaron J. Barth, Edward M. Cackett, Gisella De Rosa, Rick Edelson, Jonathan Gelbord, Yasaman Homayouni, Keith Horne, Erin A. Kara, Gerard A. Kriss, Nahum Arav, Elena Dalla Bontà, Maryam Dehghanian, Gary J. Ferland, Carina Fian, Diego H. González Buitrago, Dragana Ilić, Shai Kaspi

Physics and Astronomy Faculty Publications

The AGN Space Telescope and Optical Reverberation Mapping (STORM) 2 campaign targeted Mrk 817 with intensive multiwavelength monitoring and found its soft X-ray emission to be strongly absorbed. We present results from 157 near-IR spectra with an average cadence of a few days. Whereas the hot dust reverberation signal as tracked by the continuum flux does not have a clear response, we recover a dust reverberation radius of ∼90 lt-days from the blackbody dust temperature light curve. This radius is consistent with previous photometric reverberation mapping results when Mrk 817 was in an unobscured state. The heating/cooling process we observe …


A Comparison Of Time-Dependent Cloudy Astrophysical Code Simulations With Experimental X-Ray Spectra From Kev Laser-Generated Argon Plasmas, N. Rathee, F. P. Keenan, R. J. R. Williams, Gary Ferland, S. J. Rose, S. White, D. Riley Jan 2026

A Comparison Of Time-Dependent Cloudy Astrophysical Code Simulations With Experimental X-Ray Spectra From Kev Laser-Generated Argon Plasmas, N. Rathee, F. P. Keenan, R. J. R. Williams, Gary Ferland, S. J. Rose, S. White, D. Riley

Physics and Astronomy Faculty Publications

We have generated strongly photoionized Ar plasmas in experiments designed to use primarily X-ray l-shell line emission generated from Ag foils irradiated by the VULCAN high-power laser at the UK Central Laser Facility. The principle of the experiment is that use of line emission rather than the usual sub-keV quasi-blackbody source allows keV radiation to play a more dominant role compared to softer X-rays and thus mimic the effect of a blackbody with a higher effective spectral temperature. Our aim is to reproduce in the laboratory the extreme photoionization conditions found in accretion-powered astrophysical sources. In this paper, we compare …


Deep Learning-Based Quantification Of Tall Fescue Abundance In Pastures, Rose E. Binkley, Samuel R. Revolinski, Echo Elizabeth Gotsick, Ray Smith, Zeya Wang, Katsutoshi Mizuta Jan 2026

Deep Learning-Based Quantification Of Tall Fescue Abundance In Pastures, Rose E. Binkley, Samuel R. Revolinski, Echo Elizabeth Gotsick, Ray Smith, Zeya Wang, Katsutoshi Mizuta

Plant and Soil Sciences Faculty Publications

Accurate and rapid measurement of tall fescue abundance is essential for efficient forage management and mitigating livestock exposure to potential endophyte-related toxicity. Traditional visual estimation methods are labor-intensive and are subject to change depending on the observer doing the calculations, which limits their scalability and consistency. This study explores the application of deep learning techniques to automate and improve the classification of tall fescue abundance across pasture systems in Kentucky. Ground-truth abundance classes were evaluated using one of the traditional methods with occupancy grid and compared against estimates derived from red-green-blue images. Two convolutional neural network architectures, YouOnlyLookOnce (YOLO) and …


Driving Employee Engagement Across Sectors: Current Evidence And An Agenda For Future Research, Taha Hameduddin, Kerstin Alfes, Adrian Ritz Jan 2026

Driving Employee Engagement Across Sectors: Current Evidence And An Agenda For Future Research, Taha Hameduddin, Kerstin Alfes, Adrian Ritz

Public Policy and Administration Faculty Publications

Employee engagement has emerged as a critical employee attitude linked to employee motivation and organisational performance and has successfully embedded itself in governments around the world. Apart from a few exceptions, however, much of what we know about engagement does not attend to the institutional context of public institutions and whether private-sector theories and approaches to driving employee engagement work well in public sector organisations. To address this gap, we systematically review the evidence on antecedents of employee engagement, and determine whether and how sectoral differences may matter. We then discuss the findings and contextualise the debate surrounding the employee …


Consumer Perceptions Of Farmers Market Performance: A Comparative Analysis Across States And Age Groups, Azita Varziri, Timothy A. Woods, Shuoli Zhao Jan 2026

Consumer Perceptions Of Farmers Market Performance: A Comparative Analysis Across States And Age Groups, Azita Varziri, Timothy A. Woods, Shuoli Zhao

Agricultural Economics Faculty Publications

The USDA Agricultural Marketing Service has invested in direct-to-consumer initiatives to expand local food consumption and enhance farmers market opportunities. To evaluate the effectiveness of these efforts, this study employs a sample-selected ordered probit model to analyze consumer perceptions of farmers market performance across four states in the Southeast United States. Specifically, we examine differences in awareness and performance of product quality, diversity, and market infrastructure. Awareness and perceptions vary significantly by age, other demographics, and state. These insights provide market organizers and policymakers with data-driven strategies to tailor marketing efforts and improve engagement across diverse consumer segments.


The Association Between Personal Particulate Matter Exposures And Cognitive Function Among Stroke Patients, Kentucky, Usa, Nana Afua Ankomah Dei Jan 2026

The Association Between Personal Particulate Matter Exposures And Cognitive Function Among Stroke Patients, Kentucky, Usa, Nana Afua Ankomah Dei

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Stroke, a major cause of long-term disability and cognitive problems in the U.S., significantly affects people’s quality of life. Exposure to particulate matter (PM2.5) may result in systemic inflammation and oxidative stress, which can worsen the cognitive function of post-thrombectomy stroke patients. This project thus assessed the relationship between PM2.5 exposure and its effect on the cognitive function of post-thrombectomy stroke patients. Fifteen stroke patients (9 non-Appalachian and 6 Appalachian) undergone thrombectomy were recruited. Personal PM2.5 exposure was measured using wearable sensors for a week during the study period. Montreal Cognitive Assessment (MoCA) scores and covariates …


Philsongs: A Study Of Campfire Music Performed At Scouting America’S Philmont Scout Ranch (2014 To 2021), Ellyn Rager Jan 2026

Philsongs: A Study Of Campfire Music Performed At Scouting America’S Philmont Scout Ranch (2014 To 2021), Ellyn Rager

Theses and Dissertations--Music

This dissertation focuses on Philmont Scout Ranch, a national Scouting America high adventure base in New Mexico and the largest youth camp in the world, arguing that music at Philmont serves as a cultural force that fosters an intensive communal bond among staff and campers by blending participatory and presentational music-making practices, while producing and reinforcing memories of Philmont through interpretive performances that negotiate the place’s historical narratives. Using surveys, interviews, and Thomas Turino’s framework of participatory and presentational music-making to interpret the author’s 100 hours of field recordings, this study examines aspects of Philmont’s musical habits between 2014 and …


Forage News [2026-02], University Of Kentucky Jan 2026

Forage News [2026-02], University Of Kentucky

Forage News

No abstract provided.


Psychosocial Strengths Associated With Higher Functioning After Interpersonal Adversity In The United Kingdom And Ireland, Matthew Brooks, Victoria Banyard, Xiafei Wang, Sherry Hamby Jan 2026

Psychosocial Strengths Associated With Higher Functioning After Interpersonal Adversity In The United Kingdom And Ireland, Matthew Brooks, Victoria Banyard, Xiafei Wang, Sherry Hamby

Social Work Faculty Publications

Objective: Over the past two decades, positive psychology research has identified correlates of resilience. Although a range of strengths have been explored, there is a need to identify specific strengths that best support individuals to thrive after interpersonal trauma and adversity. This study assessed the contribution of 24 strengths from the Values in Action (VIA) positive psychology survey, alongside five other measures of strengths identified from resilience research, to identify those that show most promise.

Method: In total, 1,440 adults from the United Kingdom and Ireland completed the online VIA survey, and questions on five psychosocial strengths (ecoconnections, …


Clopidogrel Versus Aspirin Monotherapy Following Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: An Updated Meta- Analysis Of 162,829 Patients, Mohammed A. Elbahloul, Ahmed Mansour, Amr Galal, Walaa M. Moawad, Manar Khaled, Ahmed Wahdan Kasem, Eman E. Labeeb, Islam Y. Elgendy Jan 2026

Clopidogrel Versus Aspirin Monotherapy Following Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: An Updated Meta- Analysis Of 162,829 Patients, Mohammed A. Elbahloul, Ahmed Mansour, Amr Galal, Walaa M. Moawad, Manar Khaled, Ahmed Wahdan Kasem, Eman E. Labeeb, Islam Y. Elgendy

Gill Heart & Vascular Institute Faculty Publications

Background: Dual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI) remains a cornerstone for preventing ischemic events; however, the optimal long-term single antiplatelet therapy after completion of DAPT remains unclear. We aimed to compare clopidogrel and aspirin monotherapy after completion of the standard duration of DAPT.

Methods: A systematic search was conducted on PubMed, Scopus, Cochrane Library, and Web of Science from inception to April 2025. We included randomized clinical trials and observational studies that compared aspirin versus clopidogrel monotherapy after completion of standard-duration DAPT. The primary and co-primary outcomes were major adverse cardiovascular events (MACE) and major bleeding, respectively. …


Cross-Linking Peg Microgels With Mesoporous Organosilica Nanoparticles To Engineer Microporous Annealed Particle Scaffold Properties, Jonathan M. Zuidema, Alessandro Ajo, Marco Carofiglio, Luisa De Cola Jan 2026

Cross-Linking Peg Microgels With Mesoporous Organosilica Nanoparticles To Engineer Microporous Annealed Particle Scaffold Properties, Jonathan M. Zuidema, Alessandro Ajo, Marco Carofiglio, Luisa De Cola

Mechanical Engineering Faculty Publications

Microporous annealed particle (MAP) scaffolds composed of cross-linked microgels are emerging as important biomaterials due to their modular design, high porosity, and large surface area, which allow for highly tailored properties, cellular infiltration, nutrient and waste exchange, and improved drug release characteristics. To further expand on these technologies and enhance their modular design, thiolated mesoporous organosilica nanoparticles (ssMSN-SH), which degrade in response to glutathione, were first cross-linked inside of 4-arm poly(ethylene glycol) maleimide microgels. The microgel size, rheological properties, and payload release characteristics were determined. Hierarchical MAP scaffolds were then created by cross-linking 4-arm poly(ethylene glycol) maleimide microgels with ssMSN-SH. …


Implementing A “Naloxone Hub With Many Spokes” Model In Kentucky: Partner Agency Perspectives On Implementation Strategies, Hannah K. Knudsen, Michael Goetz, Shaquita Andrews-Higgins, Sandra Back-Haddix, Olivia A. Davis, Patricia R. Freeman, Douglas R. Oyler, Sharon L. Walsh Jan 2026

Implementing A “Naloxone Hub With Many Spokes” Model In Kentucky: Partner Agency Perspectives On Implementation Strategies, Hannah K. Knudsen, Michael Goetz, Shaquita Andrews-Higgins, Sandra Back-Haddix, Olivia A. Davis, Patricia R. Freeman, Douglas R. Oyler, Sharon L. Walsh

Behavioral Science Faculty Publications

Background: Overdose education and naloxone distribution (OEND) is a vitally important evidence-based practice for addressing the ongoing opioid epidemic. During the HEALing Communities Study in Kentucky, OEND was dramatically scaled up in eight counties using a “hub with many spokes” model and multifaceted implementation strategies. This aim of this manuscript is to describe qualitative perspectives of partner organizations regarding the utility of the implementation strategies used to expand OEND.   Method: Twenty small-group and 24 individual qualitative interviews were conducted with staff from 44 agencies that implemented OEND through partnerships with the study team. Interviews were conducted 6–8 months after the …


Cross-Neutralization And Antigenic Characterization Of Simian And Equine Group A Rotaviruses, Shalini Soni, Lianne G. Eertink, Ni Shuisong, Alan T. Loynachan, Samantha M. Barnum, Emma Adam, Michael A. Kennedy, Dan Wang, Feng Li Jan 2026

Cross-Neutralization And Antigenic Characterization Of Simian And Equine Group A Rotaviruses, Shalini Soni, Lianne G. Eertink, Ni Shuisong, Alan T. Loynachan, Samantha M. Barnum, Emma Adam, Michael A. Kennedy, Dan Wang, Feng Li

Veterinary Science Faculty Publications

Rotaviral diarrhea in foals is caused by two dominant G3P[12] and G14P[12] genotypes of equine rotavirus A (ERVA). Protection of foals against ERVA infection and disease is achievable by passive antibody transfer through colostrum from mares receiving inactivated monovalent G3P[12] vaccine. Simian rotavirus SA11 G3P[2] is also included in ERVA vaccines to protect foals. Here, we characterized cross-neutralization and protection among three distinctive rotaviruses carrying the same or different G (defined by VP7) or P (defined by VP4) genotype by using a rabbit and equine monospecific antisera panel coupled with structural and computational analyses of viral epitopes. Data from these …


Data-Driven Thresholds For Standardized Classification Of Severe Alzheimer’S Disease Neuropathology Using Digital Neuropathology, Ryan K. Shahidehpour, Allison M. Neltner, Mitchell A. Klusty, Cole Corbett, Angelique D. Gonzalez, David A. Gutman, David W. Fardo, Adam D. Bachstetter, Cody Bumgardner, Margaret E. Flanagan, Peter T. Nelson Jan 2026

Data-Driven Thresholds For Standardized Classification Of Severe Alzheimer’S Disease Neuropathology Using Digital Neuropathology, Ryan K. Shahidehpour, Allison M. Neltner, Mitchell A. Klusty, Cole Corbett, Angelique D. Gonzalez, David A. Gutman, David W. Fardo, Adam D. Bachstetter, Cody Bumgardner, Margaret E. Flanagan, Peter T. Nelson

Sanders-Brown Center on Aging Faculty Publications

Alzheimer's disease neuropathological changes (ADNC)—operationalized with semi-quantitative parameters—represent the consensus-based gold standard for diagnostic evaluation of disease severity. Although useful, ADNC diagnostic frameworks have limitations, particularly in advanced disease stages where pathological severity varies widely within a given diagnostic category. Further, some individuals lacking cognitive impairment are inappropriately categorized as having severe ADNC. In this study, quantitative pathology metrics and alternative tissue sampling schemes were integrated with data about premortem cognitive status, in order to derive clinically informed neuropathologic diagnostic thresholds. Specific goals of the current study were to generate data-driven, standardized diagnostic cut-points, with the most severe stages of …


Knowledge Based Automated Planning For Non-Coplanar Vmat Stereotactic Radiosurgery In Ocular Malignancies, Chase Cochran, Shane Mccarthy, William St. Clair, Damodar Pokhrel Jan 2026

Knowledge Based Automated Planning For Non-Coplanar Vmat Stereotactic Radiosurgery In Ocular Malignancies, Chase Cochran, Shane Mccarthy, William St. Clair, Damodar Pokhrel

Radiation Medicine Faculty Publications

Background and Purpose: Stereotactic radiosurgery/radiotherapy (SRS/SRT) has emerged as a less invasive alternative to enucleation in the management of ocular malignancies. SRS/SRT planning is time-consuming, complex, and the plan quality depends on the experience of the treatment planner. We demonstrate the use of RapidPlan modeling in conjunction with HyperArc for the treatment of ocular diseases to improve planning efficiency, consistency, and quality.

Materials and Methods: A HyperArc-based RapidPlan (HARP) model was iteratively trained on 80 patient datasets that simulated ocular malignancies. Twenty additional patient datasets were reserved for model testing and comparison with manual plans. Each testing dataset was both …


Designing Theranostic Radiopharmaceutical Trials For Uterine Cervix Cancer, Denise Fabian, Molly E. Buffington, Brianna S. Cagle, Steve M. Keefe, Michael K. Schultz, Charles A. Kunos Jan 2026

Designing Theranostic Radiopharmaceutical Trials For Uterine Cervix Cancer, Denise Fabian, Molly E. Buffington, Brianna S. Cagle, Steve M. Keefe, Michael K. Schultz, Charles A. Kunos

Radiation Medicine Faculty Publications

Designing and interpreting early phase trials of theranostic radiopharmaceuticals remains challenging because it is difficult to isolate effective levels of activity in enriched patient populations that would be worth following up in later-phase development. This study explores the known challenges and emerging opportunities for clinical research on patients with uterine cervical cancer. We identified eight randomized combination trials for advanced-stage uterine cervix cancer that were activated between 2011 and 2022 and tabulated their results to determine whether combinations were better than individual constituents and which suitable study population is best situated for the study of a new theranostic agent. In …


From Anxiety To Stewardship: An Autoethnographic Study Of Therapist Development, Christie Ellis Jan 2026

From Anxiety To Stewardship: An Autoethnographic Study Of Therapist Development, Christie Ellis

Theses and Dissertations--Family Sciences

Routine outcome monitoring (ROM) is recognized as an evidence-informed practice for supporting psychotherapy outcomes, yet limited research has examined how therapists-in-training experience integrating ROM into their clinical development. This autoethnographic study investigated the role of ROM in shaping therapist identity development within a university-based marriage and family therapy training clinic. Qualitative data included 34 reflective journal entries analyzed using reflexive thematic analysis, and quantitative data included multiple client outcome trajectories across several clinical measures compared descriptively with prototypical change trajectories derived from MFT-PRN datasets. Qualitative findings reflected a developmental progression from initial anxiety and performance concerns toward increased confidence, attunement, …


Localized Periodontitis In Young Individuals: Aggregatibacter Jp2 Clone, Immunological Dysfunctions And Other Stories, Luigi Nibali, Meaad M. Alamri, Manuela Maria Viana Miguel, Luciana M. Shaddox Jan 2026

Localized Periodontitis In Young Individuals: Aggregatibacter Jp2 Clone, Immunological Dysfunctions And Other Stories, Luigi Nibali, Meaad M. Alamri, Manuela Maria Viana Miguel, Luciana M. Shaddox

Oral Health Science Faculty Publications

Grade C molar-incisor pattern periodontitis (C-MIP) is the latest in a series of names given to a unique phenotype, characterized by an aggressive and rapid loss of tooth-supporting structures, starting early in life and usually affecting first molars and incisors. Although much less prevalent than the more generalized “chronic” forms of this disease in adults, it affects mostly young individuals of lower socioeconomic status and African descent, or from mixed-race populations, and shows a strong familial aggregation, pointing to a possible genetic contribution, yet not fully elucidated. Even though most of the studies report this disease in adolescents/young adults, it …


Glial Cytokine Modulation Improves Sleep And Circadian Disruption In Female Saa Knock-In Mice Of Alzheimer’S-Related Pathology, Teresa Macheda, Margaret R. Hawkins, Carrie E. Johnson, Madison G. Lapid, Haleigh R. Whitlock, Savannah M. Shepard, Makayla F. Cox, Kelly N. Roberts, Leke Bytyqi, Heather M. Hash, Omar A. Abou El-Ezz, Mohammed Abou El-Ezz, Katharina Kohler, Sridhar Sunderam, Bruce F. O'Hara, Linda J. Van Eldik, Michael Paul Murphy, Marilyn J. Duncan, Adam D. Bachstetter Jan 2026

Glial Cytokine Modulation Improves Sleep And Circadian Disruption In Female Saa Knock-In Mice Of Alzheimer’S-Related Pathology, Teresa Macheda, Margaret R. Hawkins, Carrie E. Johnson, Madison G. Lapid, Haleigh R. Whitlock, Savannah M. Shepard, Makayla F. Cox, Kelly N. Roberts, Leke Bytyqi, Heather M. Hash, Omar A. Abou El-Ezz, Mohammed Abou El-Ezz, Katharina Kohler, Sridhar Sunderam, Bruce F. O'Hara, Linda J. Van Eldik, Michael Paul Murphy, Marilyn J. Duncan, Adam D. Bachstetter

Neuroscience Faculty Publications

Introduction: Sleep and circadian disturbances are early Alzheimer's disease (AD) features, yet mechanisms linking amyloid pathology, neuroinflammation, and sex differences remain unclear.

Methods: We longitudinally assessed sleep, circadian rhythms, and cognition in female and male hAPPSAA knock-in and control mice from 2 to 19 months using piezoelectric monitoring. Aged mice (15 months) received MW151, a glial cytokine inhibitor (2.5 mg/kg, every other day, 6 weeks).

Results: Only females exhibited midlife reductions in light-phase sleep, increased rhythm fragmentation, and reduced rhythm stability, coinciding with selective reversal learning deficits, effects independent of amyloid or cytokine burden. MW151 increased light-phase sleep and …


Accelerator Based Fusion Reactor With Magnetic Mirror, Keh-Fei Liu Jan 2026

Accelerator Based Fusion Reactor With Magnetic Mirror, Keh-Fei Liu

Physics and Astronomy Faculty Publications

We consider an implementation of the novel accelerator-based fusion reactor scheme using a setup in which ion and electron beams are injected into the end openings of an axisymmetric magnetic mirror. While the magnetic mirror ensures transverse confinement of the plasma, the injected beams contribute to axial confinement, thereby extending the overall plasma lifetime. The ion beam energy is initially set above the resonance region of the fusion reactions, allowing fusion to occur both via resonance and thermal mechanisms as the beam slows down to the plasma temperature. Beam energy loss (stopping power) contributes to plasma heating, offsetting radiative losses …


Emission-Line Diagnostics At Z ≳ 2: A Probe Of The Ionizing Spectrum And Α-Enhancement Beyond Cosmic Noon, Leonardo Clarke, Natalie Lam, Alice E. Shapley, Michael W. Topping, Gabriel B. Brammer, Ryan L. Sanders, Naveen Reddy, Shreya Karthikeyan Jan 2026

Emission-Line Diagnostics At Z ≳ 2: A Probe Of The Ionizing Spectrum And Α-Enhancement Beyond Cosmic Noon, Leonardo Clarke, Natalie Lam, Alice E. Shapley, Michael W. Topping, Gabriel B. Brammer, Ryan L. Sanders, Naveen Reddy, Shreya Karthikeyan

Physics and Astronomy Faculty Publications

We analyze several key rest-optical emission-line ratios in a sample of 828 galaxies as well as composite spectra from JADES DR3 in the range 1.4 <  z <  7. These emission-line ratios include: [O iii]λ5008/Hβ, [N ii]λ6585/Hα, [S ii]λλ6718, 6733/Hα, [O i]λ6302/Hα, O32, R23, Ne3O2, and RO2Ne3. We find evidence for a harder ionizing spectrum at z ∼ 3.5 compared to z ∼ 2 at fixed gas-phase metallicity, resulting in a pronounced shift in the star-forming galaxy locus on the [N ii]/Hα Baldwin-Phillips-Terlevich (BPT) diagram and the O32 versus R23 diagram. At …


Chinese Lesbian, Gay, And Bisexual Positive Identity Measure (C-Lgb-Pim), Yawen Yang, Ellen D. B. Riggle, Fang Wang, Mengyan Wu, Ye Sun, Huilan Liu, Lisha Dai Jan 2026

Chinese Lesbian, Gay, And Bisexual Positive Identity Measure (C-Lgb-Pim), Yawen Yang, Ellen D. B. Riggle, Fang Wang, Mengyan Wu, Ye Sun, Huilan Liu, Lisha Dai

Gender and Women's Studies Faculty Publications

To support research and interventions using a positive, strength-based framework of lesbian, gay, and bisexual (LGB) identities in China, this study translates the Lesbian, Gay, and Bisexual Positive Identity Measure (LGB-PIM) into Standard Chinese and evaluating its reliability and validity among Chinese sexual minorities. Following Brislin’s standardized translation procedures (translation, back-translation, cultural adaptation, and pretesting), the scale retained 25 items across 5 dimensions. A convenience sample of 392 participants underwent assessments of internal consistency (α = 0.92), retest reliability (α = 0.80), structural validity (68.54% variance explained), and construct validity. The five-dimensional structure showed robust convergent validity (AVE > 0.50, CR …


Effects Of Constant Time Delay Using Multiple Acquisition Exemplars On The Generalization Of Self-Instruction To Complete Vocational Tasks For High School Students With Intellectual Disability, Anna Norby Jan 2026

Effects Of Constant Time Delay Using Multiple Acquisition Exemplars On The Generalization Of Self-Instruction To Complete Vocational Tasks For High School Students With Intellectual Disability, Anna Norby

Theses and Dissertations--Early Childhood, Special Education, and Counselor Education

This study presents findings from a multiple probe design that evaluated the effects of constant time delay with multiple acquisition exemplars on the acquisition and generalization of self-instruction to complete vocational tasks for high school students with intellectual disability. The research included three high school students with intellectual disability, and data were analyzed across baseline, intervention, and generalization conditions. Instruction targeted the use of self-instruction procedures embedded within vocational tasks, with multiple exemplars incorporated during acquisition to promote stimulus generalization. Participants were screened using a set of pre-arranged vocational tasks to identify existing skill levels and determine appropriate instructional targets, …


Culturally Sustaining Pedagogy Through Popular Music And Media In Elementary Music Education, Martina Vasil Jan 2026

Culturally Sustaining Pedagogy Through Popular Music And Media In Elementary Music Education, Martina Vasil

Music Faculty Publications

Elementary music teachers in the United States face many challenges today, including an increasing cultural divide between teachers and students, worsening student behavior, and excessive exposure to technology in children’s lives. These challenges are magnified due to the hundreds of students elementary music teachers see weekly, the lack of teaching and planning time, and inadequate teaching resources, making it difficult to fully understand the culture and learning needs of every child. However, music educators may find culturally sustaining pedagogy (CSP) a useful tool for meeting the needs of a diverse student body. Further, when teachers engage in kid culture, the …