Digital Commons Network^™

Developing A Cross-Asset Allocation Mechanism, Jon Wilcoxson, Bryan Gibson, Bethany Paris

Kentucky Transportation Center Research Report

The Kentucky Transportation Cabinet (KYTC) has developed several tools and methods to compare the value of proposed projects within specific programs and asset classes, including the Enhanced Bridge Prioritization Index, Enhanced Pavement Prioritization Index, and the Strategic Highway Investment Formula for Tomorrow (SHIFT). Although immensely valuable, these methods and tools do not offer a convenient way of comparing the contributions of individual projects to meeting overall KYTC performance goals. As such, the Cabinet needs a robust mechanism for comparing the impact of projects across its capital, safety, and asset management programs. Following a review of cross-asset allocation frameworks described in …

Extended-Release 7-Day Injectable Buprenorphine For Patients With Minimal To Mild Opioid Withdrawal., Gail D'Onofrio, Andrew A. Herring, Jeanmarie Perrone, Kathryn Hawk, Elizabeth A. Samuels, Ethan Cowan, Erik Anderson, Ryan Mccormack, Kristen Huntley, Patricia Owens, Shara Martel, Mark Schactman, Michelle R. Lofwall, Sharon L. Walsh, James Dziura, David A. Fiellin

Behavioral Science Faculty Publications

IMPORTANCE: Buprenorphine is an effective yet underused treatment for opioid use disorder (OUD).

OBJECTIVE: To evaluate the feasibility (acceptability, tolerability, and safety) of 7-day injectable extended-release buprenorphine in patients with minimal to mild opioid withdrawal.

DESIGN, SETTING, AND PARTICIPANTS: This nonrandomized trial comprising 4 emergency departments in the Northeast, mid-Atlantic, and Pacific geographic areas of the US included adults aged 18 years or older with moderate to severe OUD and Clinical Opiate Withdrawal Scale (COWS) scores less than 8 (minimal to mild), in which scores range from 0 to 7, with higher scores indicating increasing withdrawal. Exclusion criteria included methadone-positive …

Applying Machine Learning Models Derived From Administrative Claims Data To Predict Medication Nonadherence In Patients Self-Administering Biologic Medications For Inflammatory Bowel Disease, Christian Rhudy, Courtney Perry, Michael Wesley, David Fardo, Cody Bumgardner, Syed Hassan, Terrence Barrett, Jeffery Talbert

Biostatistics Faculty Publications

BACKGROUND: Adherence to self-administered biologic therapies is important to induce remission and prevent adverse clinical outcomes in Inflammatory bowel disease (IBD). This study aimed to use administrative claims data and machine learning methods to predict nonadherence in an academic medical center test population.

METHODS: A model-training dataset of beneficiaries with IBD and the first unique dispense of a self-administered biologic between June 30, 2016 and June 30, 2019 was extracted from the Commercial Claims and Encounters and Medicare Supplemental Administrative Claims Database. Known correlates of medication nonadherence were identified in the dataset. Nonadherence to biologic therapies was defined as a …

Dual Light Emission Of Cssni3-Based Powders Synthesized Via A Mechanochemical Process, Xuan Huang, Xiaobing Tang, Xiyu Wen, Yuebin Charles Lu, Fuqian Yang

Chemical and Materials Engineering Faculty Publications

Lead toxicity has hindered the wide applications of lead halide perovskites in optoelec- tronics and bioimaging. A significant amount of effort has been made to synthesize lead-free halide perovskites as alternatives to lead halide perovskites. In this work, we demonstrate the feasibility of synthesizing CsSnI3-based powders mechanochemically with dual light emissions under ambi- ent conditions from CsI and SnI2 powders. The formed CsSnI3-based powders are divided into CsSnI3-dominated powders and CsSnI3-contained powders. Under the excitation of ultraviolet light of 365 nm in wavelength, the CsSnI3-dominated powders emit green light with a wavelength centered at 540 nm, and the CsSnI3-contained powders …

Diffuse Reflectance Spectroscopy For Optical Characterizations Of Orthotopic Head And Neck Cancer Models In Vivo, Pranto Soumik Saha, Jing Yan, Caigang Zhu

Markey Cancer Center Faculty Publications

We demonstrated an easy-to-build, portable diffuse reflectance spectroscopy device along with a Monte Carlo inverse model to quantify tissue absorption and scattering-based parameters of orthotopic head and neck cancer models in vivo. Both tissue-mimicking phantom studies and animal studies were conducted to verify the optical spectroscopy system and Monte Carlo inverse model for the accurate extraction of tissue optical properties. For the first time, we reported the tissue absorption and scattering coefficients of mouse normal tongue tissues and tongue tumor tissues. Our in vivo animal studies showed reduced total hemoglobin concentration, lower tissue vascular oxygen saturation, and increased tissue scattering …

Response To Replication Stress And Maintenance Of Genome Stability By Wrn, The Werner Syndrome Protein, David K. Orren, Amrita Machwe

Markey Cancer Center Faculty Publications

Werner syndrome (WS) is an autosomal recessive disease caused by loss of function of WRN. WS is a segmental progeroid disease and shows early onset or increased frequency of many characteristics of normal aging. WRN possesses helicase, annealing, strand exchange, and exonuclease activities and acts on a variety of DNA substrates, even complex replication and re- combination intermediates. Here, we review the genetics, biochemistry, and probably physiological functions of the WRN protein. Although its precise role is unclear, evidence suggests WRN plays a role in pathways that respond to replication stress and maintain genome stability particularly in telomeric regions.

The Use Of Grasslands To Improve Water Quality In The New York City Watershed, D J. Flaherty, J Drelich Jr

IGC Proceedings (1977-2023)

The purpose of this paper is to demonstrate how grasslands are used in the New York City (NYC) Watershed to improve water quality. A Watershed Agricultural Program was established to voluntarily implement Pollution Prevention Best Management Practices on watershed farms. Grasslands have been used in Whole Farm Plans to reduce nutrients, sediments and other toxic materials reaching New York City’s water supply. Rotational grazing has been used to limit access to streams and stream banks and improve nutrient distribution on pastures. Improved grassland management also helps correct the nutrient balance on the farm and facilitates better nutrient management. Brush removal …

Vertical Distribution In Grass Swards: Interactions Between Dry Matter And Nutritional Quality, D R. Buckmaster, R H. Mohtar, S L. Fales

IGC Proceedings (1977-2023)

A field experiment was conducted to study the distribution of mass and quality over plant height throughout the growing season in a pure stand of orchardgrass (Dactylis glomerata L.). When plant density (expressed as kg DM/ha per cm height) is plotted against a height of strata, all treatments show a similar linear shape distribution. ADF and NDF concentrations declined with sward height. Fall treatments had lower ADF and NDF concentrations than summer treatments. Conversely, CP concentrations showed an increase with plant height. Fall treatments showed higher CP than spring and summer treatments. Defoliation management did not affect orchardgrass quality. …

Manitoba Green Gold- An Extension Project Linking High Quality Hay With High Profits, Dennis Joosse

IGC Proceedings (1977-2023)

Improving the quality of harvested forage is seen as an important step in improving the productivity of Manitoba’s beef, dairy and cash hay operations. One of the most important determinants of forage quality is stage of maturity when harvested. Timely cutting is particularly important during first cut because it represents a major portion of the total harvest, and forage quality drops rapidly during this period.

A New Degree For Land Based Industries At Massey University, New Zealand, J Hodgson, R D. Anderson, J H. Kirkman

IGC Proceedings (1977-2023)

A brief description is given of the background, structure and management of a new Bachelor of Applied Science degree introduced at Massey University in 1994 to meet the changing needs of the primary sector industries. Examples are given of the flexibility of choice offered to students enrolling in the programme, with particular reference to opportunities in plant and pastoral science. Enrollment statistics for the first two years of the programme are discussed.

The Evolving International Grassland Congress, L R. Humphreys

IGC Proceedings (1977-2023)

The locations of the International Grassland Congresses are listed. Analysis of the disciplinary themes of papers presented at five Congresses from 1937 to 1993 indicated a considerable homeostasis of content. The plant genetic base for grassland improvement received most attention, and this, together with plant physiology, plant ecology and soil science contributed 52 to 57 per cent of the subject matter at all five Congresses. Emergent topics are mentioned.

Development And Fate Of Seedlings Of Three Temperate Legumes Following Oversowing, M H. Awan, P D. Kemp, D J. Barker, M A. Choudhary

IGC Proceedings (1977-2023)

Oversown seeds of subterranean clover (Trifolium subterraneum L.), strawberry clover (T. fragiferum L.) and caucasian clover (T. ambiguum Bieb.) were monitored for 40 days to identify the stage of development at which the seed of these temperate pasture legumes failed at varying moisture levels. Intact sods of glyphosate-sprayed pasture were taken to a glasshouse, subjected to factorial combination of three soil surface moisture levels (low, medium, high) and three legume species. Overall, 70, 52 and 31% of seed of subterranean, strawberry and caucasian clovers,respectively, produced a visible radicle or seedling. The greatest loss of potential seedlings occured following …

Characterizing Effective Fiber With Particle Size And Fiber Concentration Interactions, D R. Buckmaster, A J. Heinrichs, R A. Ward, B P. Lammers

IGC Proceedings (1977-2023)

Both physical form and chemical nature of fiber is important to ruminant animals. A recently developed method for determining particle size distribution was used to characterize typical distributions for forages and total mixed rations (TMR) from the Mid-Atlantic region of the U.S. An effective fiber index (EFI) and modified effective fiber index (MEFI) are proposed which link physical and chemical characteristics. The EFI and MEFI are computed by weighting NDF concentrations by particle size distribution and effectiveness for contribution towards a rumen mat and rumination.

The Energetic Utilization Of Forages In Fresh And Dried Condition By Ruminants, W Jentsch

IGC Proceedings (1977-2023)

The influence of dehydration of forages on digestibility and energy utilization was measured by indirect calorimetry in respiration chambers with adult wether sheep as a model for ruminants. Comparisons were carried out between fresh and carefully dried forages (experiment 1) and between fresh and not only carefully but also severely dried forages (experiment 2). Careful drying caused no change, but severe drying decreased energy and especially crude protein digestibility. There were no differences in utilization of metabolizable energy between fresh and carefully or severely dried forages.

Storage Losses In Large Round Bale Using Various Storage Methods For Six And Eighteen Months, R C. Reeder, D H. Samples, H M. Bartholomew, S L. Boyles

IGC Proceedings (1977-2023)

Grass hay was baled with a variety of balers and tying materials in June, 1994 and 1995, at Jackson, Ohio. The bales were prepared and stored several ways. Waste hay accounted for less than ten percent of the dry matter after storage for six and eighteen months in all cases except one (a plastic wrap system intended for use with haylage). Bales stored inside had no waste. The best outdoor storage system, with less than one percent waste, used a ‘bale bonnet’ (top half covered with a plastic sheet) with the bale on a slatted pallet. One group of bales …

Influence Of Drying Method And Temperature Of Ruminal Degradable Protein Of Switchgrass, D E. Farnham, K J. Moore, J R. George

IGC Proceedings (1977-2023)

The nutritional value of herbage protein fed to ruminant livestock can be influenced greatly by the extent to which it is degraded in the rumen. This study was conducted to determine if drying method and temperature alters measurements of in situ ruminal escape protein (EP) of switchgrass herbage. Switchgrass harvested at the pre-heading stage was either air dried, freeze dried, or oven dried at 38, 49, 60, or 71° C. Samples from each of the six drying treatments were digested in situ in Dacron bags for 4, 8, 12, or 16 h. Drying treatment had a significant impact on EP …

Comparative Characteristics During Wilting For Forage Harvested By Maceration Vs. A Conventional Roller-Conditioner, Suwarno, K M. Wittenberg, W P. Mccaughey

IGC Proceedings (1977-2023)

Two studies were conducted to monitor forage nutrient and microbial changes during wilting of alfalfa (Medicago sativa L.) forage in response to varying degrees of maceration at harvest. Early bloom alfalfa forage was harvested with either a roller conditioner (Control) or a macerator, with four degrees of maceration (Light, Light plus, Moderate and Severe) imposed. Macerated forage reached an 80% dry matter 10-27 hours sooner than roller-conditioned forage, the most rapid drying rates being associated with the more severely macerated treatments. Total bacteria and lactic acid bacteria populations tended (P < 0.07 and P < 0.08, respectively) to increase with maceration. Macerated forage, when exposed to precipitation, had lower (P < 0.05) crude protein and higher (P < 0.05) fiber concentration than roller-conditioned forage. Macerated forage, exposed to 2 cm precipitation during wilting without precipitation reached 80% DM sooner than conventionally cut alfalfa exposed to no precipitation.

Forage Maceration On A Self-Propelled Mower: Effect Of Windrow Deposition And Inversion, P Savoie, D Tremblay, J Lajoie, M Roberge, S P. Lemay

IGC Proceedings (1977-2023)

Forage maceration is an intensive conditioning technique applied at mowing with high speed rolls. Maceration has been observed to enhance the field wilting rate, produce a more efficient silage fermentation and accelerate ruminal degradation. An important technical hurdle has been to scale up maceration for wide mowers without reducing capacity. The paper descibes a three-roll maceration unit that was integrated in a self-propelled 4.2 m wide mower. A capacity of 2.75 ha/h and throughputs up to 14 t DM (dry matter)/h or 64 t WM (wet matter)/h were achieved in alfalfa and timothy. Compared to a commercial mower-conditioner, the macerator …

Gene Transfer Of Ryegrasses: Down-Regulation Of Major Pollen Allergens In Transgenic Plants, X L. Wu, X D. Ye, Z Y. Wang, I Potrykus, G Spangenberg

IGC Proceedings (1977-2023)

The objective of this study is to generate transgenic ryegrass plants with a down-regulation of two major pollen allergenic proteins Lol p I and Lol p II. Antisense vectors for Lol p I and Lol p II cDNAs driven by the pollen-specific promoter Zm13 have been constructed. Corresponding transgenic plants have been recovered by particle inflow gun-mediated microprojectile bombardment of embryogenic suspension cells from perennial and Italian ryegrass using chimeric Act1-hph gene as a selectable marker. Their transgenic nature has been demonstrated by Southern hybridization analysis. The analysis of reproductive development and accumulation of pollen allergens in the transgenic ryegrasses …

Study Of The Diversity Of Soil Animal Community In The Songnen Plain Grassland Of China, Yin Xiuqin, Zhu Tingcheng, Zhong Weiyan, Peng Wu Kui

IGC Proceedings (1977-2023)

This paper makes a diversity study of 8 habitats of soil animal communities in Songnen plain grassland. The research shows that the better the habitat condition is, the higher the diversity index of soil animals, and the worse the habitat condition is the lower the diversity index of soil animals. The diversity of soil animal communities has a positive relationship with soil organic matter, total nitrogen, and has a negative relationship with pH value. It has no obvious relationship with soil water content and total phosphorus. The diversity of soil animal communities decreases with increasing depth of soil layer and …

Seed Proteinase Inhibitors From Annual Medics Active Against Insect Pests, M Odoardi, A Tava, F Ceciliani

IGC Proceedings (1977-2023)

Several different species of annual medics have been tested for the occurrence and concentration of trypsin inhibitors in the seed. Trypsin Inhibitory Activity (TIA) has been in fact related to the level of resistance to biotic and abiotic stresses. Wide variation was found for TIA among species, with the highest values shown by the snail medic (Medicago scutellata). After a simple and rapid procedure of chromatographic purification, the Trypsin Inhibitor (TI) from snail medic has been tested towards the trypsin-like proteinases extracted from larvae of different phytophagous insects, showing high levels of Inhibitory Activity. The complete amino acid …

Raster Map For Prediction Of Heading Date Of Timothy By Nonparametric Dvr Method, T Saigusa, K Nakashima, N Noshiro, M Tsutsumi

IGC Proceedings (1977-2023)

A system for making a raster map for predicting the heading date of timothy (Phleum pratense L.) at first cutting for every 1km2 plot was developed to supply information for smooth harvest of forage of good quality in a dairy farming area of Hokkaido. Daily mean air temperature for every 1km2 plot was estimated with data from a network of meteorological observatories and data base of the Japan Meteorological Agency. Day length could be calculated from latitude and calendar day. Using these two environmental factors, heading date of timothy at first cutting for each area was predicted by nonparametric DVR …

Growth Response Of Australian Temperate Pasture Species To Co2 Enrichment, T P. Bolger, J M. Lilley, R M. Gifford, J R. Donnelly

IGC Proceedings (1977-2023)

Growth responses to a doubling of the atmospheric CO2 concentration for 15 species represented in temperate pastures of southern Australia were investigated in a glasshouse experiment. The final dry weight increase due to CO2 enrichment averaged 34% across species but varied widely. The variation in CO2 response was greater among species within botanical groups than it was among groups. The CO2 response of a number of ‘desirable’, but also a number of ‘undesirable’ species was greater than the mean response, suggesting that these species may increase their proportion in pastures as atmospheric CO2 rises. Our results do not support the …

North American Grass Species In Reclamation Of Coal-Mining Areas In Poland, W Majtkowski

IGC Proceedings (1977-2023)

Suitability of perennial grass species as a main decorative element was evaluated during reclamation of a coal-dump in Bierun near Katowice. Materials for the above testing were species selected from grass collection of Botanical Garden of PBAI in Bydgoszcz. The most promising species were: Carex grayi (sedge), Andropogon gerardi, A. scoparius and Spartina michauxiana (grasses from North America flora), Elymus racemosus, Koeleria cristata, Melica altissima, Miscanthus sacchariflorus (European or Asian origin). Addition of bio-gel positively affected plant development, while no significant differences were observed between different levels of fertilizers.

Grassland Development By Erosion Control On Hill Slope Using Multi Function Filter And Vegetation, M S. Alam, K Hosoyamada

IGC Proceedings (1977-2023)

Soil erosion by water is a major soil degradation process in the world and constrains of land development for cultivation. Japan is a mountain based country with a large number of volcanos and most of the soils are highly erodible volcanic ash soil. Therefore, soils will erode when rainfall is sufficient. Since 1992 an intensive programme has been undertaken to develop grassland or cropland by controlling soil erosion on hill slopes. Multi function filter (MFF) have been used along with the application of different rooty summer and winter grass seeds to protect surface soil and rapid germination of deep vegetation …

Influence Of Drying Method And Temperature On Ruminal Degradable Protein Of Switchgrass, D E. Farnham, K J. Moore, J R. George

IGC Proceedings (1977-2023)

The nutritional value of herbage protein fed to ruminant livestock can be influenced greatly by the extent to which it is degraded in the rumen. This study was conducted to determine if drying method and temperature alters measurements of in situ ruminal escape protein (EP) of switchgrass herbage. Switchgrass harvested at the pre-heading stage was either air dried, freeze dried, or oven dried at 38, 49, 60, or 710 C. Samples from each of the six drying treatments were digested in situ in Dacron bags for 4, 8, 12, or 16 h. Drying treatment had a significant impact on EP …

A Guide To Successful Management Of Collaborative Partnerships In Quantitative Research: An Illustration Of The Science Of Team Science., Alyssa Platt, Tracy Truong, Mary Boulos, Nichole E Carlson, Manisha Desai, Monica M Elam, Emily Slade, Alexandra L Hanlon, Jillian H Hurst, Maren K Olsen, Laila M Poisson, Lacey Rende, Gina-Maria Pomann

Biostatistics Faculty Publications

Data-intensive research continues to expand with the goal of improving healthcare delivery, clinical decision-making, and patient outcomes. Quantitative scientists, such as biostatisticians, epidemiologists, and informaticists, are tasked with turning data into health knowledge. In academic health centres, quantitative scientists are critical to the missions of biomedical discovery and improvement of health. Many academic health centres have developed centralized Quantitative Science Units which foster dual goals of professional development of quantitative scientists and producing high quality, reproducible domain research. Such units then develop teams of quantitative scientists who can collaborate with researchers. However, existing literature does not provide guidance on how …

Active And Retroactive Digital Newspaper Preservation, Andrew Mcdonnell

Library Faculty and Staff Publications

The University of Kentucky Libraries’ (UKL) long-running efforts to document and provide access to the state’s history via newspaper preservation have necessarily evolved over the last 80 years. As news formats and preservation technologies have changed, particularly in relation to born-digital media, the libraries’ efforts have had to keep pace. The race to preserve these materials before they disappear or are locked away on media inaccessible to modern computers is not always chronologically linear, though. Digital archivists and librarians must sometimes straddle multiple generations of technology to successfully migrate, capture, and otherwise preserve digital publications, and there is no single …

Development Of A Sms Rollout Plan And Evaluation, Gabriel Dadi, Hala Nassereddine, Farshid Taherpour, Salena Pham

Kentucky Transportation Center Research Report

Many state transportation agencies have introduced safety management systems (SMSs) to improve employee safety and health programs. These systems let employees quickly access safety and health policies, procedures, training, responsibilities, resources, and incident reporting tools, often electronically. Instituting a SMS is a critical step in adopting a proactive, data-driven approach to organizational safety. The Kentucky Transportation Cabinet Secretary’s Office of Safety (SOS) worked with Kentucky Transportation Center (KTC) to acquire, adapt, and rollout the Boosting Occupational Outcomes in Transportation Safety (BOOTS) system, a new SMS. Researchers assisted KYTC by conducting pre-rollout focus groups, helping to bring the system online, providing …

Using Knowledge Of Human Factors To Strengthen Highway Design, Chris Van Dyke, Jeff Jasper, Jill Asher, Steve Waddle

Kentucky Transportation Center Research Report

Transportation practitioners recognize that leveraging knowledge of human factors in road design is critical for delivering safe mobility to the full spectrum of multimodal road users (motorists, pedestrians, micromobility users, transit users). Understanding how psychology, cognition, and behavioral tendencies shape the ways in which different road users interact with one another and the road environment itself is critical for creating design solutions that promote safe and efficient movement. NCHRP Report 600 (Human Factors Guidelines for Road Systems) provides guidance on integrating knowledge of human factors into design practice. While the report is a valuable resource, it appears to …